A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) (VICTOR)

December 4, 2025 updated by: Merck Sharp & Dohme LLC

A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction

The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

6106

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Santa Fe, Argentina, 3000
        • Centro de Investigaciones Clinicas del Litoral ( Site 4354)
    • Buenos Aires
      • CABA, Buenos Aires, Argentina, C1060ABN
        • CEDIC ( Site 4363)
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1027AAP
        • Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)
      • Ramos Mejía, Buenos Aires, Argentina, B1704ETD
        • DIM Clínica Privada ( Site 4359)
      • Zárate, Buenos Aires, Argentina, B2800DGH
        • Instituto de Investigaciones Clinicas Zarate ( Site 4360)
    • Buenos Aires F.D.
      • Buenos Aires, Buenos Aires F.D., Argentina, C1120AAC
        • Centro Médico Viamonte-Clinical Research ( Site 4361)
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000DEJ
        • Fundacion Estudios Clinicos ( Site 4356)
  • Australia
    • Queensland
      • Brisbane, Queensland, Australia, 4029
        • Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)
      • Brisbane, Queensland, Australia, 4032
        • The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)
      • Brisbane, Queensland, Australia, 4064
        • Core Research Group ( Site 0452)
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital-Cardiology ( Site 0456)
      • Bedford Park, South Australia, Australia, 5042
        • Flinders Medical Centre-Cardiology Research ( Site 0455)
    • Western Australia
      • Subiaco, Western Australia, Australia, 6008
        • St. John of God Subiaco Hospital ( Site 0457)
  • Austria
      • Salzburg, Austria, 5020
        • Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv
      • Vienna, Austria, 1210
        • Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep
    • Styria
      • Graz, Styria, Austria, 8036
        • Medizinische Universität Graz-Department of Cardiology ( Site 0351)
    • Upper Austria
      • Braunau am Inn, Upper Austria, Austria, 5280
        • Krankenhaus St. Josef Braunau ( Site 0354)
    • Vienna
      • Vienna, Vienna, Austria, A-1190
        • Imed19-privat ( Site 0353)
  • Brazil
      • Rio de Janeiro, Brazil, 22280-003
        • Hospital Pro-Cardiaco ( Site 0556)
      • São Paulo, Brazil, 05403-900
        • Incor - Instituto do Coracao ( Site 0557)
    • Ceará
      • Fortaleza, Ceará, Brazil, 60864-190
        • Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)
    • Goiás
      • Goiânia, Goiás, Brazil, 74605-020
        • Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)
    • Paraná
      • Curitiba, Paraná, Brazil
        • PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90880-480
        • Hospital Mae de Deus ( Site 0564)
    • Sergipe
      • Acaraju, Sergipe, Brazil, 49055-530
        • Centro de Pesquisa Clinica do Coracao ( Site 0561)
    • São Paulo
      • Campinas, São Paulo, Brazil, 13060-080
        • Instituto de Pesquisa clinica de Campinas ( Site 0551)
      • Ribeirão Preto, São Paulo, Brazil, 14026-900
        • CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)
      • Ribeirão Preto, São Paulo, Brazil, 14048900
        • Hospital de Clínicas de Ribeirão Preto ( Site 0559)
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 4Z6
        • Heritage Medical Research Clinic ( Site 0679)
      • Edmonton, Alberta, Canada, T6G 2B7
        • University Of Alberta Hospital ( Site 0669)
    • British Columbia
      • Victoria, British Columbia, Canada, V8R 1B2
        • Victoria Heart Institute Foundation ( Site 0680)
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2H 2A6
        • St. Boniface General Hospital ( Site 0667)
    • New Brunswick
      • Moncton, New Brunswick, Canada, E1G 1A7
        • G A Research Associates ( Site 0652)
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)
    • Ontario
      • Cambridge, Ontario, Canada, N1R 6V6
        • Cambridge Cardiac Care Centre ( Site 0658)
      • Newmarket, Ontario, Canada, L3Y 2P6
        • PACE Cardiology ( Site 0675)
      • North York, Ontario, Canada, M6B 3H7
        • North York Diagnostic and Cardiac Centre ( Site 0682)
      • Oakville, Ontario, Canada, L6K 3W7
        • Oakville Cardiovascular Research LP ( Site 0657)
      • Oshawa, Ontario, Canada, L1J 2K1
        • Private Practice - Dr. James Cha ( Site 0655)
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials ( Site 0654)
      • Toronto, Ontario, Canada, M1B 5N1
        • Corcare-Corcare Cardiovascular Research ( Site 0660)
      • Toronto, Ontario, Canada, M4P 1E4
        • Medicus MFC Research Clinic ( Site 0676)
    • Quebec
      • Laval, Quebec, Canada, H7M 3L9
        • Hôpital de la Cité-de-la-Santé ( Site 0673)
      • Montreal, Quebec, Canada, H1T 1C8
        • Institut de Cardiologie de Montreal ( Site 0661)
      • Montreal, Quebec, Canada, H3G 1A4
        • Montreal General Hospital ( Site 0653)
      • Saint-Jérôme, Quebec, Canada, J7Z 2V4
        • Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
      • Terrebonne, Quebec, Canada, J6V 2H2
        • Hopital Pierre-Le Gardeur ( Site 0674)
      • Trois-Rivières, Quebec, Canada, G9A 4P3
        • Diex Recherche Trois-Rivieres ( Site 0677)
  • Chile
    • Coquimbo Region
      • La Serena, Coquimbo Region, Chile, 1720430
        • IC La Serena Research ( Site 0769)
    • Los Lagos Region
      • Osorno, Los Lagos Region, Chile, 5311089
        • Clinica Alemana Osorno ( Site 0768)
    • Los Ríos Region
      • Valdivia, Los Ríos Region, Chile, 5110683
        • Clinical Research Chile SpA ( Site 0761)
    • Region M. de Santiago
      • Santiago, Region M. de Santiago, Chile, 7500587
        • Enroll SpA ( Site 0755)
      • Santiago, Region M. de Santiago, Chile, 7640881
        • Clinica Dermacross ( Site 0760)
      • Santiago, Region M. de Santiago, Chile, 7770086
        • Espacio Eme ( Site 0762)
      • Santiago, Region M. de Santiago, Chile, 8053095
        • Hospital y CRS El Pino ( Site 0763)
      • Santiago, Region M. de Santiago, Chile, 8330111
        • Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)
      • Santiago, Region M. de Santiago, Chile, 8380465
        • Clínica Ensenada ( Site 0753)
      • Santiago, Region M. de Santiago, Chile, 8910259
        • Cardio Sur ( Site 0756)
    • Región de Valparaíso
      • Viña del Mar, Región de Valparaíso, Chile, 2520598
        • ONCOCENTRO APYS ( Site 0770)
    • Región de la Araucanía
      • Temuco, Región de la Araucanía, Chile, 4780000
        • Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)
  • China
    • Anhui
      • Hefei, Anhui, China, 230036
        • Anhui Provincil Hospital South District ( Site 0920)
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100029
        • Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)
      • Beijing, Beijing Municipality, China, 100049
        • Aero Space Center Hospital ( Site 0918)
      • Beijing, Beijing Municipality, China, 100050
        • Beijing Friendship Hospital-Cardology ( Site 0865)
      • Beijing, Beijing Municipality, China, 102218
        • Beijing Tsinghua Changgung Hospital ( Site 0911)
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400010
        • The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)
      • Wanzhou, Chongqing Municipality, China, 404199
        • Chongqing Three Gorges Central Hospital ( Site 0913)
    • Gansu
      • Lanzhou, Gansu, China, 730030
        • Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)
    • Guangdong
      • Foshan, Guangdong, China, 528041
        • The First People's Hospital of Foshan ( Site 0898)
      • Guangzhou, Guangdong, China, 510080
        • Guangdong Provincial People's Hospital-Cardiology ( Site 0852)
      • Guangzhou, Guangdong, China, 510120
        • Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)
      • Guangzhou, Guangdong, China, 510630
        • The First Affiliated Hospital of Jinan University ( Site 0897)
      • Shenzhen, Guangdong, China, 518053
        • The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)
    • Hainan
      • Haikou, Hainan, China, 570311
        • Hainan General Hospital ( Site 0894)
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150001
        • The First Hospital of Harbin Medical University-Cardiology ( Site 0903)
    • Hubei
      • Wuhan, Hubei, China, 430022
        • Wuhan Union Hospital ( Site 0919)
    • Hunan
      • Changsha, Hunan, China, 410004
        • Changsha Central Hospital ( Site 0854)
      • Changsha, Hunan, China, 410008
        • Xiangya Hospital Central South University-Cardiological Department ( Site 0899)
      • Changsha, Hunan, China, 410013
        • The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)
      • Changsha, Hunan, China, 410005
        • Hunan Provincial People's Hospital ( Site 0857)
    • Inner Mongolia
      • Baotou, Inner Mongolia, China, 014040
        • BAO TOU CENTRAL HOSPITAL ( Site 0866)
    • Jiangsu
      • Nanjing, Jiangsu, China, 210000
        • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy
      • Nanjing, Jiangsu, China, 210011
        • The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)
      • Wuxi, Jiangsu, China, 214002
        • Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)
      • Wuxi, Jiangsu, China, 214023
        • Wuxi People's Hospital-Cardiovascular Department ( Site 0870)
      • Xuzhou, Jiangsu, China, 221006
        • The Affiliated Hospital of Xuzhou Medical College ( Site 0910)
      • Yangzhou, Jiangsu, China, 225001
        • Northern Jiangsu People's Hospital ( Site 0861)
      • Zhenjiang, Jiangsu, China, 212001
        • Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)
    • Jilin
      • Changchun, Jilin, China, 130033
        • China-Japan Union Hospital-department of cardiology ( Site 0916)
      • Siping, Jilin, China, 136000
        • Siping Central People's Hospital-Cardiovascular Department ( Site 0915)
    • Liaoning
      • Shenyang, Liaoning, China, 110016
        • The People's Hospital of Liaoning Province ( Site 0859)
    • Shaanxi
      • Xi'an, Shaanxi, China, 710061
        • The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit
      • Xi'an, Shaanxi, China, 710068
        • Shaanxi provincial people's hospital ( Site 0853)
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200001
        • Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)
      • Shanghai, Shanghai Municipality, China, 200032
        • Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)
      • Shanghai, Shanghai Municipality, China, 200065
        • Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)
      • Shanghai, Shanghai Municipality, China, 200090
        • Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)
      • Shanghai, Shanghai Municipality, China
        • Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • West China Hospital Sichuan University ( Site 0904)
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300211
        • The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)
      • Tianjin, Tianjin Municipality, China, 300222
        • Tianjin Chest Hospital-Cardiology ( Site 0901)
      • Tianjin, Tianjin Municipality, China
        • Tianjin People' s Hospital ( Site 0867)
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310003
        • The First Affiliated Hospital, Zhejiang University ( Site 0907)
      • Hangzhou, Zhejiang, China, 310052
        • The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)
      • Hangzhou, Zhejiang, China, 311599
        • Zhejiang Provincial People's Hospital ( Site 0914)
      • Lishui, Zhejiang, China, 323000
        • People's Hospital of Lishui City-department of cardiovascular ( Site 0862)
      • Wenzhou, Zhejiang, China, 325000
        • The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia, 050021
        • Fundación Centro de Investigación Clínica CIC ( Site 0955)
      • Medellín, Antioquia, Colombia, 050034
        • Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)
      • Medellín, Antioquia, Colombia, 50030
        • Rodrigo Botero S.A.S ( Site 0953)
    • Atlántico
      • Barranquilla, Atlántico, Colombia, 080020
        • Clinica de la Costa S.A.S. ( Site 0954)
      • Barranquilla, Atlántico, Colombia, 080020
        • Corazon IPS ( Site 0964)
      • Barranquilla, Atlántico, Colombia, 080020
        • IPS Centro Científico Asistencial S.A.S ( Site 0952)
    • Caldas Department
      • Manizales, Caldas Department, Colombia, 170004
        • IPS Médicos Internistas de Caldas ( Site 0959)
    • Santander Department
      • Bucaramanga, Santander Department, Colombia, 680002
        • Instituto Del Corazón De Bucaramanga ( Site 0960)
      • Piedecuesta, Santander Department, Colombia, 681017
        • Fundación Cardiovascular de Colombia ( Site 0961)
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)
      • Cali, Valle del Cauca Department, Colombia, 760036
        • Centro de Investigaciones Clinicas SAS ( Site 0957)
      • Cali, Valle del Cauca Department, Colombia
        • Clínica Imbanaco S.A.S ( Site 0963)
  • Czechia
      • Louny, Czechia, 44001
        • KardioBusak s.r.o. ( Site 1051)
      • Prague, Czechia, 12808
        • Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)
      • Znojmo, Czechia, 66902
        • KIGE ( Site 1060)
    • Brno-mesto
      • Brno, Brno-mesto, Czechia, 625 00
        • Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)
      • Brno, Brno-mesto, Czechia, 636 00
        • Vojenská Nemocnice Brno-Internal department ( Site 1055)
    • Central Bohemia
      • Slaný, Central Bohemia, Czechia, 274 01
        • Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)
    • Mlada Boleslav
      • Mladá Boleslav, Mlada Boleslav, Czechia, 293 01
        • Klinika Dr. Pirka ( Site 1065)
    • Praha 4
      • Prague, Praha 4, Czechia, 14021
        • Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)
    • Praha 6
      • Prague, Praha 6, Czechia, 169 02
        • Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)
    • South Moravian
      • Brno, South Moravian, Czechia, 602 00
        • MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)
      • Brno, South Moravian, Czechia, 60200
        • Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)
  • Denmark
    • Capital Region
      • Copenhagen, Capital Region, Denmark, 2100
        • Rigshospitalet-Cardiology ( Site 1161)
      • Copenhagen, Capital Region, Denmark, 2300
        • Amager Hospital ( Site 1163)
      • Hellerup, Capital Region, Denmark, 2900
        • Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)
      • Hillerød, Capital Region, Denmark, 3400
        • Nordsjællands Hospital - Hillerød ( Site 1159)
      • Hvidovre, Capital Region, Denmark, 2650
        • Hvidovre Hospital-259 ( Site 1151)
    • Central Jutland
      • Aarhus, Central Jutland, Denmark, 8200
        • Aarhus Universitetshospital, Skejby ( Site 1160)
      • Viborg, Central Jutland, Denmark, 8800
        • Regionshospitalet Viborg ( Site 1166)
    • North Denmark
      • Hjørring, North Denmark, Denmark, 9800
        • Sygehus Vendsyssel Hjoerring ( Site 1164)
    • Region Sjælland
      • Holbæk, Region Sjælland, Denmark, 4300
        • Holbæk Sygehus-Cardiology ( Site 1152)
      • Roskilde, Region Sjælland, Denmark, 4000
        • Roskilde Sygehus ( Site 1162)
      • Slagelse, Region Sjælland, Denmark, 4200
        • Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)
    • Region Syddanmark
      • Esbjerg, Region Syddanmark, Denmark, 6700
        • Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)
      • Svendborg, Region Syddanmark, Denmark, 5700
        • Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)
  • France
    • Alpes-Maritimes
      • Nice, Alpes-Maritimes, France, 06000
        • Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)
    • Aquitaine
      • Pessac, Aquitaine, France, 33600
        • CHU Bordeaux Haut-Leveque ( Site 1362)
    • Eure-et-Loir
      • Le Coudray, Eure-et-Loir, France, 28630
        • Centre Hospitalier Louis Pasteur ( Site 1360)
    • Haute-Garonne
      • Toulouse, Haute-Garonne, France, 31059
        • CHU Rangueil-Cardiology ( Site 1351)
    • Haute-Normandie
      • Rouen, Haute-Normandie, France, 76031
        • CHU Charles Nicolle ( Site 1354)
    • Lorraine
      • Vandœuvre-lès-Nancy, Lorraine, France, 54511
        • Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé
    • Paris
      • Le Kremlin-Bicêtre, Paris, France, 94270
        • Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)
    • Provence-Alpes-Côte d'Azur Region
      • Toulon, Provence-Alpes-Côte d'Azur Region, France, 83100
        • Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)
    • Rhone
      • Lyon, Rhone, France, 69677
        • Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)
    • Vendee
      • La Roche-sur-Yon, Vendee, France, 85000
        • CHD Vendee ( Site 1361)
    • Île-de-France Region
      • Paris, Île-de-France Region, France, 75013
        • Pitie Salpetriere University Hospital ( Site 1363)
  • Germany
      • Berlin, Germany, 10789
        • Praxis Rankestrasse ( Site 1461)
      • Hamburg, Germany, 22041
        • Cardiologicum Hamburg ( Site 1467)
    • Baden-Wurttemberg
      • Heidelberg, Baden-Wurttemberg, Germany, 69120
        • Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)
    • Bavaria
      • Coburg, Bavaria, Germany
        • Klinikum Coburg ( Site 1464)
      • Nuremberg, Bavaria, Germany, 90402
        • Kardiologische Gemeinschaftspraxis ( Site 1460)
      • Würzburg, Bavaria, Germany, 97080
        • Universitaetsklinikum Wuerzburg ( Site 1458)
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60596
        • ClinPhenomics CVC GmbH ( Site 1457)
      • Frankfurt am Main, Hesse, Germany, 65929
        • Klinikum Frankfurt Höchst ( Site 1463)
      • Langen, Hesse, Germany, 63225
        • Asklepios Klinik Langen ( Site 1473)
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30625
        • Medizinische Hochschule Hannover ( Site 1476)
    • Mecklenburg-Vorpommern
      • Greifswald, Mecklenburg-Vorpommern, Germany, 17475
        • Universitätsmedizin Greifswald ( Site 1470)
    • North Rhine-Westphalia
      • Cologne, North Rhine-Westphalia, Germany, 50733
        • St. Vinzenz-Hospital-Cardiology ( Site 1455)
      • Leverkusen, North Rhine-Westphalia, Germany, 51375
        • Klinikum Leverkusen ( Site 1453)
      • Mönchengladbach, North Rhine-Westphalia, Germany, 41063
        • Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)
      • Siegen, North Rhine-Westphalia, Germany, 57072
        • Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)
    • Rhineland-Palatinate
      • Ludwigshafen am Rhein, Rhineland-Palatinate, Germany, 67063
        • Klinikum Ludwigshafen ( Site 1456)
      • Neuwied, Rhineland-Palatinate, Germany, 56564
        • Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)
    • Saxony
      • Dresden, Saxony, Germany, 01067
        • Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)
      • Dresden, Saxony, Germany, 01277
        • Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)
      • Dresden, Saxony, Germany, 01307
        • Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)
    • Thuringia
      • Erfurt, Thuringia, Germany, 99097
        • Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)
  • Greece
      • Thessaloniki, Greece, 546 36
        • AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)
      • Thessaloniki, Greece, 57001
        • European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)
    • Attica
      • Athens, Attica, Greece, 115 27
        • General Hospital of Athens Hippokratio ( Site 1552)
      • Athens, Attica, Greece, 115 28
        • Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)
      • Athens, Attica, Greece, 11527
        • General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)
      • Athens, Attica, Greece, 142 33
        • Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)
      • Chaïdári, Attica, Greece, 124 62
        • ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)
      • Marousi, Attica, Greece, 151 23
        • Hygeia Hospital-6th cardiology clinic ( Site 1560)
    • Evros
      • Alexanroupolis, Evros, Greece, 681 00
        • University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)
    • Thessaly
      • Larissa, Thessaly, Greece, 411 10
        • University General Hospital of Larissa ( Site 1555)
    • West Greece
      • Ioannina, West Greece, Greece, 455 00
        • University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)
  • Guatemala
      • Guatemala City, Guatemala, 01001
        • Unidad De Diagnostico Cardiologico ( Site 1652)
      • Guatemala City, Guatemala, 01010
        • Clinica Medica ( Site 1651)
      • Guatemala City, Guatemala
        • Unidad De Diagnostico Cardiologico ( Site 1654)
  • Hong Kong
      • Aberdeen, Hong Kong, 999077
        • Grantham Hospital ( Site 1753)
      • Hksar, Hong Kong
        • Queen Mary Hospital-Medicine - Cardiology ( Site 1752)
      • Hong Kong, Hong Kong
        • Princess Margaret Hospital ( Site 1755)
      • Shatin, Hong Kong, NT
        • Prince of Wales Hospital ( Site 1751)
  • Hungary
      • Budapest, Hungary, 1085
        • Szent Rókus Kórház ( Site 1858)
      • Budapest, Hungary, 1096
        • Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)
      • Budapest, Hungary, 1122
        • Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)
      • Budapest, Hungary, 1932
        • Óbudai Egészségügyi Centrum ( Site 1861)
      • Nyíregyháza, Hungary, 4400
        • Medifarma 98 Kft-Outpatient Clinic ( Site 1859)
      • Zalaegerszeg, Hungary, 8900
        • OEC Clinical Research - Zalaegerszeg ( Site 1864)
    • Baranya
      • Pécs, Baranya, Hungary, 7623
        • CoroMed ( Site 1867)
      • Pécs, Baranya, Hungary, 7624
        • Pécsi Tudományegyetem Klinikai Központ ( Site 1865)
    • Bekes County
      • Békéscsaba, Bekes County, Hungary, 5600
        • Private Practice - Dr. Lakatos Ferenc ( Site 1854)
      • Gyula, Bekes County, Hungary, 5700
        • Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)
    • Bács-Kiskun county
      • Kecskemét, Bács-Kiskun county, Hungary, 6000
        • Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)
    • Csongrád megye
      • Szeged, Csongrád megye, Hungary, 6725
        • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)
    • Győr-Moson-Sopron
      • Mosonmagyaróvár, Győr-Moson-Sopron, Hungary, 9200
        • TaNa Med ( Site 1866)
    • Pest County
      • Kistarcsa, Pest County, Hungary, 2143
        • Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)
    • Szekesfehervar
      • Székesfehérvár, Szekesfehervar, Hungary, 8000
        • CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)
    • Szekszard
      • Szekszárd, Szekszard, Hungary, 7100
        • Tolna Megyei Balassa János Kórház ( Site 1868)
    • Veszprém megye
      • Balatonfüred, Veszprém megye, Hungary, 8230
        • DRC Gyógyszervizsgáló Központ ( Site 1869)
  • Ireland
      • Dublin, Ireland, D08 E9P6
        • St. James's Hospital-Cardiology ( Site 1951)
    • Dublin
      • Dún Laoghaire, Dublin, Ireland, A96 D628
        • St. Michael's Hospital ( Site 1955)
  • Israel
      • Ashdod, Israel, 7747629
        • Assuta Ashdod Medical Center-Cardiology ( Site 2063)
      • Hadera, Israel, 3810101
        • Hillel Yaffe Medical Center-Heart Institute ( Site 2058)
      • Haifa, Israel, 3109601
        • Rambam Health Care Campus-Cardiology ( Site 2053)
      • Jerusalem, Israel, 9013102
        • Shaare Zedek Medical Center-Cardiology ( Site 2055)
      • Jerusalem, Israel, 9112001
        • Hadassah Medical Center-Heart Institute ( Site 2062)
      • Nahariya, Israel, 2210001
        • Galilee Medical Center-Cardiology ( Site 2051)
      • Petah Tikva, Israel, 49100
        • Rabin Medical Center-Cardiology - CHF ( Site 2052)
      • Ramat Gan, Israel, 5262100
        • Sheba Medical Center-Leviev Heart Center ( Site 2064)
      • Rehovot, Israel, 7610001
        • Kaplan Medical Center-Heart Institution ( Site 2054)
      • Ẕerifin, Israel, 609300
        • Yitzhak Shamir Medical Center-Cardiology ( Site 2060)
  • Italy
      • Bergamo, Italy, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)
      • Bologna, Italy, 40138
        • IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)
      • Brescia, Italy, 25123
        • Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)
      • Pavia, Italy, 27100
        • Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)
      • Perugia, Italy, 06132
        • University of Perugia ( Site 2164)
      • Torino, Italy, 10126
        • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)
    • Emilia-Romagna
      • Cona, Emilia-Romagna, Italy, 44124
        • Azienda Ospedaliero Universitaria S.Anna ( Site 2152)
    • Friuli Venezia Giulia
      • Trieste, Friuli Venezia Giulia, Italy, 34149
        • Cattinara Hospital-Cardiovascular Department ( Site 2162)
    • Lazio
      • Rome, Lazio, Italy, 00161
        • Policlinico Umberto I ( Site 2166)
    • Lombardy
      • Milan, Lombardy, Italy, 20122
        • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)
      • Milan, Lombardy, Italy, 20138
        • Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)
    • Milano
      • Milan, Milano, Italy, 20162
        • ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)
    • Roma
      • Rome, Roma, Italy, 00163
        • IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)
    • Tuscany
      • Siena, Tuscany, Italy, 53100
        • ospedale le scotte ( Site 2163)
  • Malaysia
    • Kedah
      • Alor Star, Kedah, Malaysia, 05460
        • Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)
    • Kelantan
      • Kubang Kerian, Kelantan, Malaysia, 16150
        • Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)
    • Kuala Lumpur
      • Lembah Pantai, Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre ( Site 2351)
    • Pahang
      • Kuantan, Pahang, Malaysia, 25100
        • Hospital Tengku Ampuan Afzan ( Site 2353)
    • Sabah
      • Kota Kinabalu, Sabah, Malaysia, 88300
        • Hospital Queen Elizabeth II ( Site 2359)
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Sarawak Heart Centre ( Site 2352)
    • Selangor
      • Sungai Buloh, Selangor, Malaysia, 47000
        • UiTM Sungai Buloh Campus ( Site 2354)
    • Terengganu
      • Kuala Terengganu, Terengganu, Malaysia, 20400
        • Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)
  • Mexico
      • Aguascalientes, Mexico, 20230
        • Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)
      • Oaxaca City, Mexico, 68000
        • Oaxaca Site Management Organization ( Site 2459)
      • Oaxaca City, Mexico, 68020
        • Centro de Investigacion Clinica de Oaxaca ( Site 2457)
    • Chihuahua
      • Chihuahua City, Chihuahua, Mexico, 31203
        • Medivest Centro de Investigación Integral ( Site 2460)
    • Coahuila
      • Torreón, Coahuila, Mexico, 27000
        • CIMAB SA de CV ( Site 2456)
    • Estado de Baja California
      • Tijuana, Estado de Baja California, Mexico, 22500
        • Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)
    • Guerrero
      • Acapulco de Juárez, Guerrero, Mexico, 39901
        • Hospital General de Acapulco ( Site 2469)
    • Hidalgo
      • Pachuca, Hidalgo, Mexico, 42000
        • Grupo Ollin Care ( Site 2476)
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44150
        • Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)
      • Guadalajara, Jalisco, Mexico, 44160
        • Cardiocent de Guadalajara S.C. ( Site 2464)
      • Guadalajara, Jalisco, Mexico, 44670
        • Instituto Jalisciense de Metabolismo SC ( Site 2467)
    • Mexico City
      • Mexico City, Mexico City, Mexico, 06720
        • HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)
      • Mexico City, Mexico City, Mexico, 10400
        • Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)
      • Mexico City, Mexico City, Mexico, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)
      • Mexico City, Mexico City, Mexico, 14080
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64460
        • Unidad biomedica avanzada monterrey ( Site 2462)
      • San Nicolás de los Garza, Nuevo León, Mexico, 66465
        • Unidad Médica para la Salud Integral ( Site 2472)
    • San Luis Potosí
      • San Luis Potosí City, San Luis Potosí, Mexico, 78200
        • Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)
    • Sinaloa
      • Mazatlán, Sinaloa, Mexico, 82113
        • Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)
    • Tamaulipas
      • Ciudad Madero, Tamaulipas, Mexico, 89440
        • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)
    • Veracruz
      • Xalapa, Veracruz, Mexico, 91193
        • Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)
      • Xalapa, Veracruz, Mexico, 91193
        • Hospital Angeles Xalapa ( Site 2451)
    • Yucatán
      • Mérida, Yucatán, Mexico, 97070
        • Medical Care and Research SA de CV ( Site 2461)
  • New Zealand
      • Auckland, New Zealand, 0622
        • North Shore Hospital-Cardiology Research ( Site 2656)
      • Auckland, New Zealand, 1023
        • Auckland City Hospital ( Site 2659)
      • Auckland, New Zealand, 2025
        • Middlemore Clinical Trials ( Site 2658)
    • Canterbury
      • Christchurch, Canterbury, New Zealand, 8011
        • Christchurch Heart Institute ( Site 2651)
    • Otago
      • Dunedin, Otago, New Zealand, 9016
        • Dunedin Hospital-Cardiology Department ( Site 2653)
    • Waikato Region
      • Hamilton, Waikato Region, New Zealand, 3204
        • Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)
    • Wellington Region
      • Lower Hutt, Wellington Region, New Zealand, 5010
        • Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)
  • Peru
      • Lima, Peru, 15036
        • Clínica Vesalio-Cardiology ( Site 2854)
      • Lima, Peru, 15046
        • Clínica Javier Prado ( Site 2853)
      • Lima, Peru, 15076
        • Clínica El Golf-Cardiologia ( Site 2857)
      • Lima, Peru, 15088
        • Clínica Providencia ( Site 2856)
      • Lima, Peru, Lima 31
        • Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)
      • Piura, Peru, 20000
        • Clínica Belén ( Site 2858)
    • La Libertad
      • Trujillo, La Libertad, Peru, 13001
        • Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)
    • Lima
      • Jesús María, Lima, Peru, 15072
        • Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)
    • Qallaw
      • Bellavista, Qallaw, Peru, 07011
        • Hospital Alberto Sabogal Sologuren ( Site 2851)
  • Poland
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-231
        • NZOZ Centrum Medyczne KERmed ( Site 3066)
      • Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
        • Praktyka Lekarska Lidia Pawlowicz ( Site 3053)
      • Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
        • Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si
    • Lesser Poland Voivodeship
      • Chrzanów, Lesser Poland Voivodeship, Poland, 32-500
        • Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)
      • Krakow, Lesser Poland Voivodeship, Poland, 31-216
        • Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)
      • Tarnów, Lesser Poland Voivodeship, Poland, 33-100
        • Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site
    • Lower Silesian Voivodeship
      • Legnica, Lower Silesian Voivodeship, Poland, 59-220
        • Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)
      • Wrocaw, Lower Silesian Voivodeship, Poland, 50-556
        • Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)
    • Lublin Voivodeship
      • Lublin, Lublin Voivodeship, Poland, 20-857
        • NZOZ Twoja Przychodnia ( Site 3051)
      • Puławy, Lublin Voivodeship, Poland, 24-100
        • SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 02-793
        • ETG Warszawa ( Site 3052)
    • Opole Voivodeship
      • Kędzierzyn-Koźle, Opole Voivodeship, Poland, 47-200
        • Polsko-Amerykańskie Kliniki Serca ( Site 3077)
    • Podkarpackie Voivodeship
      • Rzeszów, Podkarpackie Voivodeship, Poland, 35-055
        • Centrum Medyczne Medyk ( Site 3065)
    • Podlaskie Voivodeship
      • Sokółka, Podlaskie Voivodeship, Poland, 16-100
        • Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)
    • Pomeranian Voivodeship
      • Gdynia, Pomeranian Voivodeship, Poland, 81-157
        • Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
  • Puerto Rico
      • Bayamón, Puerto Rico, 00961
        • Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)
      • Humacao, Puerto Rico, 00791
        • Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)
      • Ponce, Puerto Rico, 00717
        • Research and Cardiovascular Corp. ( Site 3152)
      • Río Grande, Puerto Rico, 00745
        • Caparra Internal Medicine ( Site 3155)
      • San Juan, Puerto Rico, 00921-3201
        • VA Caribbean Healthcare System ( Site 3157)
  • Russia
      • Saint Petersburg, Russia, 196084
        • Institute for Medical Research ( Site 3316)
    • Ivanovo Oblast
      • Ivanovo, Ivanovo Oblast, Russia, 153012
        • Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)
    • Krasnodarskiy Kray
      • Krasnodar, Krasnodarskiy Kray, Russia, 350086
        • Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)
      • Sochi, Krasnodarskiy Kray, Russia, 354057
        • City Hospital No. 4 ( Site 3269)
    • Leningradskaya Oblast'
      • Saint Petersburg, Leningradskaya Oblast', Russia, 197022
        • First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)
    • Moscow
      • Moscow, Moscow, Russia, 117292
        • State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita
    • Omsk Oblast
      • Omsk, Omsk Oblast, Russia, 644018
        • Omsk Regional Clinical Health Service Number 9 ( Site 3296)
    • Permskiy Kray
      • Perm, Permskiy Kray, Russia, 614990
        • Perm Regional Hospital for War Veterans ( Site 3272)
    • Rostov Oblast
      • Rostov-on-Don, Rostov Oblast, Russia, 344022
        • Rostov State Medical University ( Site 3259)
      • Rostov-on-Don, Rostov Oblast, Russia, 344068
        • Rostov-on-Don City Emergency Hospital ( Site 3271)
    • Ryazan Oblast
      • Ryazan, Ryazan Oblast, Russia, 390005
        • Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)
    • Sankt-Peterburg
      • Saint Petersburg, Sankt-Peterburg, Russia, 197022
        • First Pavlov State Medical University of Saint Petersburg ( Site 3288)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197341
        • Almazov National Medical Research Centre ( Site 3320)
      • Saint Petersburg, Sankt-Peterburg, Russia, 199106
        • Pokrovskaya Municipal Hospital ( Site 3252)
      • Saint Petersburg, Sankt-Peterburg, Russia, 199106
        • Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)
      • Saint Petersburg, Sankt-Peterburg, Russia, 199226
        • Astarta Clinic ( Site 3276)
    • Saratov Oblast
      • Saratov, Saratov Oblast, Russia, 410054
        • Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)
    • Tatarstan, Respublika
      • Kazan', Tatarstan, Respublika, Russia, 420101
        • Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)
    • Volgograd Oblast
      • Volgograd, Volgograd Oblast, Russia, 400131
        • Volgograd State Medical University ( Site 3258)
  • Singapore
    • Central Singapore
      • Singapore, Central Singapore, Singapore, 169609
        • National Heart Centre Singapore ( Site 3351)
      • Singapore, Central Singapore, Singapore, 308433
        • Tan Tock Seng Hospital ( Site 3353)
    • South East
      • Singapore, South East, Singapore, 529889
        • Changi General Hospital ( Site 3356)
    • South West
      • Singapore, South West, Singapore, 119074
        • National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)
  • South Africa
    • Free State
      • Bloemfontein, Free State, South Africa, 9321
        • Universitas Private Hospital-Cardiology Research ( Site 3453)
    • Gauteng
      • Johannesburg, Gauteng, South Africa, 1821
        • Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)
      • Johannesburg, Gauteng, South Africa, 2196
        • Netcare Sunninghill Hospital ( Site 3457)
      • Midrand, Gauteng, South Africa, 1685
        • Midrand Medical Centre ( Site 3466)
      • Pretoria, Gauteng, South Africa, 0001
        • University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)
      • Pretoria, Gauteng, South Africa, 0186
        • Clinical Trial Systems ( Site 3452)
      • Pretoria West, Gauteng, South Africa, 0183
        • Jongaie Research ( Site 3469)
      • Soweto, Gauteng, South Africa, 2013
        • Chris Hani Baragwanath Academic Hospital ( Site 3455)
    • KwaZulu-Natal
      • Durban, KwaZulu-Natal, South Africa, 4001
        • Enhancing Care Foundation ( Site 3456)
    • Western Cape
      • Bellville, Cape Town, Western Cape, South Africa, 7530
        • Tiervlei Trial Centre ( Site 3461)
      • Cape Town, Western Cape, South Africa, 7500
        • TREAD Research ( Site 3451)
      • Cape Town, Western Cape, South Africa, 7925
        • Professor Ntsekhe Cardiology Clinic ( Site 3454)
      • George, Western Cape, South Africa, 6529
        • Excellentis Clinical Trial Consultants ( Site 3464)
      • Paarl, Western Cape, South Africa, 7646
        • Paarl Research Centre ( Site 3468)
  • South Korea
      • Seoul, South Korea, 03080
        • Seoul National University Hospital ( Site 3557)
      • Seoul, South Korea, 03722
        • Severance Hospital, Yonsei University Health System ( Site 3552)
    • Incheon
      • Namdong-gu, Incheon, South Korea, 21565
        • Gachon University Gil Medical Center ( Site 3559)
    • Kang-won-do
      • Wŏnju, Kang-won-do, South Korea, 26426
        • Yonsei University-Wonju Severance Christian Hospital ( Site 3555)
    • Kwangju-Kwangyokshi
      • Gwangju, Kwangju-Kwangyokshi, South Korea, 61469
        • Chonnam National University Hospital ( Site 3558)
    • Kyonggi-do
      • Anyang-si, Kyonggi-do, South Korea, 14068
        • Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)
    • North Chungcheong
      • Cheongju-si, North Chungcheong, South Korea, 28644
        • Chungbuk National University Hospital-Internal medicine ( Site 3551)
    • Pusan-Kwangyokshi
      • Busan, Pusan-Kwangyokshi, South Korea, 49241
        • Pusan National University Hospital-Internal Medicine ( Site 3553)
    • Taejon-Kwangyokshi
      • Junggu, Taejon-Kwangyokshi, South Korea, 35015
        • Chungnam national university hospital ( Site 3554)
  • Spain
      • Barcelona, Spain, 08003
        • Parc de Salut Mar - Hospital del Mar ( Site 3663)
      • Barcelona, Spain, 08035
        • Hospital Universitari Vall d'Hebron ( Site 3659)
      • Madrid, Spain, 28040
        • Hospital Clinico San Carlos-Cardiology ( Site 3661)
      • Madrid, Spain, 28046
        • Hospital Universitario La Paz ( Site 3665)
      • Seville, Spain, 41014
        • Hospital Universitario Virgen de Valme ( Site 3654)
    • Barcelona
      • Badalona, Barcelona, Spain, 08916
        • Hospital Germans Trias i Pujol ( Site 3664)
    • Catalonia
      • Barcelona, Catalonia, Spain, 08023
        • Hospital Quiron Barcelona ( Site 3655)
      • L'Hospitalet de Llobregat, Catalonia, Spain, 08907
        • Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM
    • La Coruna
      • A Coruña, La Coruna, Spain, 15006
        • CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)
      • Santiago de Compostela, La Coruna, Spain, 15706
        • CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, Spain, 28034
        • Hospital Universitario Ramón y Cajal ( Site 3662)
    • Valenciana, Comunitat
      • Valencia, Valenciana, Comunitat, Spain, 46010
        • HOSPITAL CLINICO DE VALENCIA ( Site 3656)
  • Sweden
    • Dalarna County
      • Falun, Dalarna County, Sweden, 791 31
        • Falu Lasarett-Dep of Cardiology ( Site 3756)
    • Skåne County
      • Lund, Skåne County, Sweden, 22221
        • Clemenstorgets Hjartmottagning ( Site 3755)
    • Stockholm County
      • Solna, Stockholm County, Sweden, 171 64
        • Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)
      • Stockholm, Stockholm County, Sweden, 113 61
        • Aleris Specialistvård Sabbatsberg ( Site 3762)
      • Stockholm, Stockholm County, Sweden, 117 27
        • Akardo Med Site ( Site 3763)
    • Västerbotten County
      • Skellefteå, Västerbotten County, Sweden, 931 86
        • Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)
    • Västmanland County
      • Västerås, Västmanland County, Sweden, 72189
        • Västmanlands Sjukhus Västerås ( Site 3757)
    • Västra Götaland County
      • Gothenburg, Västra Götaland County, Sweden, 413 45
        • Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)
    • Örebro County
      • Örebro, Örebro County, Sweden, 701 85
        • Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)
  • Taiwan
      • Kaohsiung City, Taiwan, 807
        • Kaohsiung Medical University Hospital ( Site 3856)
      • Taichung, Taiwan, 407
        • Taichung Veterans General Hospital ( Site 3855)
      • Taipei, Taiwan, 11217
        • Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)
      • Taoyuan District, Taiwan, 333
        • Chang Gung Medical Foundation-Linkou Branch ( Site 3854)
    • Changhua
      • Changhua County, Changhua, Taiwan, 50006
        • Changhua Christian Hospital ( Site 3857)
    • Hsinchu
      • Hsinchu, Hsinchu, Taiwan, 300
        • Mackay Memorial Hospital-Hsinchu ( Site 3852)
  • Turkey (Türkiye)
      • Afyonkarahisar, Turkey (Türkiye), 03200
        • Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)
      • Ankara, Turkey (Türkiye), 06230
        • Hacettepe Universitesi ( Site 4061)
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)
      • Antalya, Turkey (Türkiye), 07100
        • Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)
      • Eskişehir, Turkey (Türkiye), 26480
        • Eskisehir Osmangazi University-Cardiology ( Site 4052)
      • Istanbul, Turkey (Türkiye), 34098
        • Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit
      • Istanbul, Turkey (Türkiye), 34662
        • Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)
      • Istanbul, Turkey (Türkiye), 34668
        • Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)
      • Izmir, Turkey (Türkiye), 35340
        • Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)
      • Izmir, Turkey (Türkiye), 35510
        • Medical Park zmir Hastanesi-cardiology ( Site 4059)
      • Kocaeli, Turkey (Türkiye), 41380
        • Kocaeli Üniversitesi-Cardiology ( Site 4060)
      • Mersin, Turkey (Türkiye), 33343
        • Mersin University ( Site 4056)
    • İzmir
      • Bornova, İzmir, Turkey (Türkiye), 35100
        • Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)
  • Ukraine
      • Kyiv, Ukraine, 01103
        • Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)
      • Kyiv, Ukraine, 02166
        • MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)
      • Kyiv, Ukraine, 03151
        • State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a
      • Kyiv, Ukraine, 03680
        • State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site
    • Cherkasy Oblast
      • Cherkasy, Cherkasy Oblast, Ukraine, 18000
        • Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292
      • Cherkasy, Cherkasy Oblast, Ukraine, 18009
        • Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)
    • Ivano-Frankivsk Oblast
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76000
        • Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76018
        • Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr
    • Kharkivs’ka Oblast’
      • Kharkiv, Kharkivs’ka Oblast’, Ukraine, 61000
        • Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)
      • Kharkiv, Kharkivs’ka Oblast’, Ukraine, 61000
        • Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)
      • Kharkiv, Kharkivs’ka Oblast’, Ukraine, 61039
        • L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti
      • Kharkiv, Kharkivs’ka Oblast’, Ukraine, 61176
        • Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)
    • Khmelnytskyi Oblast
      • Khmelnytskyi, Khmelnytskyi Oblast, Ukraine, 29001
        • Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra
    • Kyiv Oblast
      • Kiev, Kyiv Oblast, Ukraine, 03049
        • Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain
      • Kiev, Kyiv Oblast, Ukraine, 04050
        • Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)
    • Kyivska Oblast
      • Kyiv, Kyivska Oblast, Ukraine, 03037
        • Medbud Clinic ( Site 4265)
      • Kyiv, Kyivska Oblast, Ukraine, 03680
        • State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)
    • Odesa Oblast
      • Odesa, Odesa Oblast, Ukraine, 65025
        • Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42
    • Vinnytsia Oblast
      • Vinnytsia, Vinnytsia Oblast, Ukraine, 21029
        • Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)
    • Volyn Oblast
      • Lutsk, Volyn Oblast, Ukraine, 43024
        • Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)
    • Zakarpattia Oblast
      • Uzhhorod, Zakarpattia Oblast, Ukraine, 88000
        • Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un
    • Zaporizhzhia Oblast
      • Zaporizhia, Zaporizhzhia Oblast, Ukraine, 69035
        • Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site
      • Zaporizhia, Zaporizhzhia Oblast, Ukraine, 69065
        • Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)
    • Zhytomyr Oblast
      • Zhytomyr, Zhytomyr Oblast, Ukraine, 10002
        • Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci
  • United Kingdom
      • Blackpool, United Kingdom, FY3 8NR
        • Blackpool Victoria Hospital ( Site 4161)
      • Coventry, United Kingdom, CV2 2DX
        • University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)
      • Poole, United Kingdom, BH16 5PW
        • The Adam Practice ( Site 4180)
      • Stockton-on-Tees, United Kingdom, TS19 8PE
        • University Hospital of North Tees ( Site 4172)
    • Cumbria
      • Carlisle, Cumbria, United Kingdom, CA2 7HY
        • Cumberland Infirmary ( Site 4174)
      • Whitehaven, Cumbria, United Kingdom, CA28 8JG
        • West Cumberland Hospital ( Site 4176)
    • Derbyshire
      • Calow Chesterfield, Derbyshire, United Kingdom, S44 5BL
        • Chesterfield Royal Hospital ( Site 4159)
    • Dundee City
      • Dundee, Dundee City, United Kingdom, DD1 9SY
        • Ninewells Hospital and Medical School-Cardiology ( Site 4164)
    • England
      • Darlington, England, United Kingdom, DL3 7RD
        • Carmel Medical Practice ( Site 4152)
      • Dudley, England, United Kingdom, DY1 2HQ
        • Russells Hall Hospital ( Site 4153)
      • London, England, United Kingdom, SE5 9RS
        • King's College Hospital-Cardiac Research Department ( Site 4154)
      • London, England, United Kingdom, SW17 0QT
        • St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)
    • Great Britain
      • Merthyr Tydfil, Great Britain, United Kingdom, CF47 9DT
        • Prince Charles Hospital ( Site 4171)
    • Lancashire
      • Blackpool, Lancashire, United Kingdom, FY3 7EN
        • Layton Medical Centre ( Site 4184)
    • Lisburn And Castlereagh
      • Belfast, Lisburn And Castlereagh, United Kingdom, BT16 1RH
        • Ulster Hospital ( Site 4185)
    • London, City of
      • London, London, City of, United Kingdom, EC1M 5PZ
        • William Harvey Heart Centre ( Site 4169)
    • Northern Ireland
      • Belfast, Northern Ireland, United Kingdom, BT63 5QQ
        • Craigavon Area Hospital ( Site 4162)
    • Wales
      • Bridgend, Wales, United Kingdom, CF31 1RQ
        • Princess of Wales Hospital ( Site 4178)
    • Walsall
      • West Midlands, Walsall, United Kingdom, WS2 9PS
        • Walsall Manor Hospital ( Site 4179)
    • Worcestershire
      • Worcester, Worcestershire, United Kingdom, WR5 1DD
        • Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)
  • United States
    • Alabama
      • Alexander City, Alabama, United States, 35010
        • Advanced Cardiovascular - Alexander City ( Site 0038)
      • Birmingham, Alabama, United States, 35294
        • University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)
      • Huntsville, Alabama, United States, 35801
        • Heart Center Research, LLC ( Site 0156)
    • Arizona
      • Gilbert, Arizona, United States, 85297
        • Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)
    • California
      • Covina, California, United States, 91723
        • Valley Clinical Trials, Inc. ( Site 0085)
      • Los Angeles, California, United States, 90073
        • VA West Los Angeles Medical Center-Cardiology ( Site 0149)
      • Northridge, California, United States, 91325
        • Valley Clinical Trials Inc ( Site 0006)
      • Torrance, California, United States, 90502
        • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)
      • Vista, California, United States, 92081
        • Blue Coast Research Center ( Site 0053)
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Excel Medical Clinical Trials ( Site 0008)
      • Doral, Florida, United States, 33166
        • Universal Axon Clinical Research, LLC ( Site 0022)
      • Fort Lauderdale, Florida, United States, 33308
        • Holy Cross Hospital ( Site 0100)
      • Hialeah, Florida, United States, 33012
        • Indago Research and Health Center Inc ( Site 0011)
      • Hollywood, Florida, United States, 33021
        • South Florida Research Solutions ( Site 0058)
      • Jacksonville, Florida, United States, 32209
        • University of Florida - Jacksonville ( Site 0169)
      • Jacksonville, Florida, United States, 32216
        • East Coast Institute for Research, LLC ( Site 0047)
      • Miami, Florida, United States, 33173
        • Cardiovascular Research Center of South Florida ( Site 0074)
      • Miami, Florida, United States, 33175
        • ProLive Medical Research ( Site 0032)
      • Port Charlotte, Florida, United States, 33952
        • Peace River Cardiovascular Center ( Site 0088)
      • Safety Harbor, Florida, United States, 34695
        • BAYCARE MEDICAL GROUP ( Site 0099)
      • Saint Augustine, Florida, United States, 32086
        • East Coast Institute for Research - St. Augustine ( Site 0016)
      • Sarasota, Florida, United States, 34239
        • Cardiovascular Center of Sarasota ( Site 0154)
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Emory University School of Medicine ( Site 0123)
      • Columbus, Georgia, United States, 31904
        • IACT Health ( Site 0106)
      • Johns Creek, Georgia, United States, 30024
        • NSC Research ( Site 0068)
      • Macon, Georgia, United States, 31201
        • Georgia Arrhythmia Consultants and Research Institute ( Site 0042)
      • Thomasville, Georgia, United States, 31792
        • Cardiovascular Consultants of South Georgia, LLC ( Site 0137)
    • Illinois
      • Chicago, Illinois, United States, 60608
        • Mount Sinai Hospital ( Site 0050)
      • Hazel Crest, Illinois, United States, 60429
        • Chicago Medical Research ( Site 0086)
      • Peoria, Illinois, United States, 61614
        • OSF Healthcare Cardiovascular Institute ( Site 0122)
      • Peoria, Illinois, United States, 61636
        • Methodist Medical Center of Illinois ( Site 0098)
    • Indiana
      • Indianapolis, Indiana, United States, 46237
        • Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)
      • Merrillville, Indiana, United States, 46410
        • The Heart Center of Lake County Research Institute-Research ( Site 0147)
      • Munster, Indiana, United States, 46321
        • Cardiovascular Research of Northwest Indiana ( Site 0036)
      • Richmond, Indiana, United States, 47374
        • Reid Physician Associates ( Site 0054)
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • University of Iowa ( Site 0005)
    • Kansas
      • Wichita, Kansas, United States, 67207
        • Alliance for Multispecialty Research, LLC ( Site 0143)
    • Kentucky
      • Louisville, Kentucky, United States, 40205
        • Norton Healthcare-Norton Heart Specialist ( Site 0062)
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Cambridge Medical Trials ( Site 0041)
      • Hammond, Louisiana, United States, 70403
        • Louisiana Heart Center - Hammond ( Site 0004)
      • Hammond, Louisiana, United States, 70403
        • The Heart Clinic - Hammond ( Site 0155)
      • Houma, Louisiana, United States, 70360
        • Cardiovascular Institute of the South ( Site 0072)
      • Lafayette, Louisiana, United States, 70503
        • Cardiovascular Institute of the South, 3 ( Site 0096)
      • Monroe, Louisiana, United States, 71201
        • IMA Clinical Research ( Site 0112)
      • Opelousas, Louisiana, United States, 70570
        • Cardiovascular Institute of the South ( Site 0081)
    • Maryland
      • Baltimore, Maryland, United States, 21229
        • Maryland Cardiovascular Specialists ( Site 0056)
      • Lanham, Maryland, United States, 20706
        • Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)
    • Michigan
      • Southfield, Michigan, United States, 48075
        • Ascension Providence Hospital ( Site 0094)
    • Mississippi
      • Jackson, Mississippi, United States, 39209
        • Phillips Medical Services ( Site 0070)
      • Jackson, Mississippi, United States, 39216
        • The University of Mississippi Medical Center-Cardiovascular ( Site 0073)
    • Missouri
      • Columbia, Missouri, United States, 65212
        • University of Missouri Hospital ( Site 0163)
      • St Louis, Missouri, United States, 63110
        • Washington University-Department of Medicine ( Site 0044)
      • St Louis, Missouri, United States, 63136
        • St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)
    • Montana
      • Kalispell, Montana, United States, 59901
        • Logan Health Research ( Site 0017)
    • Nevada
      • Reno, Nevada, United States, 89502
        • Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)
    • New Jersey
      • Raritan, New Jersey, United States, 08869
        • Amici Clinical Research LLC-Research ( Site 0037)
      • Ridgewood, New Jersey, United States, 07450
        • The Valley Hospital ( Site 0035)
      • Washington Township, New Jersey, United States, 08080
        • Cardiovascular Associates of the Delaware Valley ( Site 0097)
    • New York
      • Buffalo, New York, United States, 14215
        • Erie County Medical Center ( Site 0160)
      • Cortlandt Manor, New York, United States, 10567
        • New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)
      • New York, New York, United States, 10029-5674
        • Icahn School of Medicine at Mount Sinai ( Site 0161)
      • The Bronx, New York, United States, 10455
        • CHEAR Center LLC ( Site 0009)
    • North Carolina
      • Lumberton, North Carolina, United States, 28358
        • Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)
      • Wilmington, North Carolina, United States, 28401
        • Accellacare - Wilmington ( Site 0090)
    • Ohio
      • Canton, Ohio, United States, 44710
        • Aultman Hospital-Cardiology Clinical Trials ( Site 0064)
      • Cincinnati, Ohio, United States, 45219
        • University of Cincinnati Medical Center-Cardiology ( Site 0071)
      • Toledo, Ohio, United States, 43606
        • ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)
    • Pennsylvania
      • Doylestown, Pennsylvania, United States, 18901
        • Doylestown Hospital-Cardiology ( Site 0030)
    • South Carolina
      • Charleston, South Carolina, United States, 29464
        • Accellacare - Charleston ( Site 0141)
    • Tennessee
      • Jackson, Tennessee, United States, 38301
        • Apex Research Foundation ( Site 0001)
      • Nashville, Tennessee, United States, 37232
        • Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)
    • Texas
      • Dallas, Texas, United States, 75216
        • Dallas VA Medical Center ( Site 0084)
      • Dallas, Texas, United States, 75235
        • Southwest Family Medicine Associates ( Site 0131)
      • El Paso, Texas, United States, 79935
        • Medresearch Inc ( Site 0043)
      • Houston, Texas, United States, 77094
        • West Houston Area Clinical Trial Consultants ( Site 0014)
      • Kerrville, Texas, United States, 78028
        • South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)
      • San Antonio, Texas, United States, 78201
        • South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)
      • Tyler, Texas, United States, 75701
        • Tyler Cardiovascular Consultants ( Site 0039)
    • Virginia
      • Falls Church, Virginia, United States, 22042
        • INOVA Fairfax Medical Campus ( Site 0136)
      • Manassas, Virginia, United States, 20109
        • Carient Heart & Vascular - Manassas ( Site 0059)
      • Norfolk, Virginia, United States, 23507
        • Sentara Norfolk General Hospital ( Site 0114)
      • Richmond, Virginia, United States, 23219
        • Dominion Medical Associates, Inc. ( Site 0089)
    • Washington
      • Puyallup, Washington, United States, 98372
        • Pulse Heart Institute - Puyallup ( Site 0119)
      • Spokane, Washington, United States, 99204
        • MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • History of chronic HF [New York Heart Association (NYHA) Class II to IV] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
  • Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
  • Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
  • A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.

Exclusion Criteria:

  • Has SBP <100 mm Hg or symptomatic hypotension.
  • Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
  • Amyloidosis or sarcoidosis.
  • Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
  • Hypertrophic cardiomyopathy.
  • Acute myocarditis or Takotsubo cardiomyopathy.
  • History of heart transplant.
  • Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.
  • Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
  • History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
  • Malignancy or other noncardiac condition limiting life expectancy to <3 years.
  • Requires continuous home oxygen for severe pulmonary disease.
  • Interstitial lung disease.
  • Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
  • Recent history (within the last year) of drug or alcohol abuse or dependence.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Vericiguat
Participants receive a starting dose of 2.5 mg of vericiguat taken orally once daily. The vericiguat dose will be titrated to 5 mg and to 10 mg.
Drug: Vericiguat
2.5, 5.0, or 10.0 mg orally once daily
Other Names:
  • MK-1242
  • BAY 1021189
Placebo Comparator: Placebo
Participants receive a starting matching placebo to vericiguat dose of 2.5 mg taken orally once daily. The matching placebo dose will be sham titrated to 5 mg and to 10 mg.
Drug: Placebo
0 mg matching placebo for 2.5 mg, 5 mg, and 10 mg of vericiguat

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization: Participants With an Event Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
The time to first occurrence of the composite endpoint of CV death or HF hospitalization was defined as the time from randomization to the first event of CV death or HF hospitalization. Randomized participants without a HF hospitalization or CV death event at the time of analysis were censored at the last available information, when the protocol pre-specified number of total CV death events was achieved (primary completion analysis data cutoff), or the date of their non-CV death, whichever occurred first. Events were confirmed by a clinical events committee (CEC). Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with a CV death or HF hospitalization event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to CV Death: Participants With an Event Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to CV death was defined as the time from randomization to CV death. Randomized participants without a CV death at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their non-CV death, whichever occurred first. CV deaths were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with a CV death event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to First Occurrence of HF Hospitalization: Participants With an Event Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to first occurrence of HF hospitalization was defined as the time from randomization to the first event of HF hospitalization. Randomized participants without an HF hospitalization at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their death, whichever occurred first. HF hospitalizations were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an HF hospitalization event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to Total HF Hospitalizations (Including First and Recurrent Events): Total Events Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to total HF hospitalizations was defined as the time from randomization to all HF hospitalization events, including time to first event and time increments between events. Randomized participants without an HF hospitalization at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their death, whichever occurred first. HF hospitalizations were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of total HF hospitalization events per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization: Participants With an Event Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
The time to first occurrence of the composite endpoint of all-cause mortality or HF hospitalization was defined as the time from randomization to the first event of all-cause mortality or HF hospitalization. Randomized participants without an all-cause mortality or HF hospitalization event at the time of analysis were censored at the last available information or when the protocol pre-specified number of total CV death events is achieved (primary analysis database cutoff), whichever occurred first. Events were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an all-cause mortality or HF hospitalization event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to All-Cause Mortality: Participants With an Event Per 100 Patient-Years
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to all-cause mortality was defined as the time from randomization to all-cause mortality. Randomized participants without an all-cause mortality event at the time of analysis were censored at their last available information or when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), whichever occurred first. All-cause mortality was confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an all-cause mortality event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Selected Nonserious Adverse Events (NSAEs)
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
An adverse event (AE) is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. Selected NSAEs are defined as nonserious AEs that meet any of the following criteria: AEs that lead to study intervention dose modification or discontinuation, AEs that lead to withdrawal from the study, or Coronavirus Disease 2019 (COVID-19) disease-related AEs. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more selected NSAEs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Serious Adverse Events (SAEs)
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
An SAE is defined as any untoward medical occurrence that, at any dose, results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly or birth defect, or other important medical events as determined by the investigator. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more SAEs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Events of Clinical Interest (ECIs)
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
ECIs were determined and reported based on the clinical judgment of the investigator. As pre-specified in the protocol, ECIs included the following: 1) Events of potential drug-induced liver injury (DILI), defined as an elevated aspartate aminotransferase or alanine aminotransferase laboratory value that is greater than or equal to 3X the upper limit of normal (ULN) and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN, 2) Events associated with symptomatic hypotension, or 3) Events associated with anemia, regardless of etiology. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more ECIs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Potential DILI ECIs
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Potential DILI ECIs were determined and reported based on the clinical judgment of the investigator. Potential DILI ECIs were defined as an elevated aspartate aminotransferase or alanine aminotransferase laboratory value that is greater than or equal to 3X the ULN and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more potential DILI ECIs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Symptomatic Hypotension ECIs
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Symptomatic hypotension ECIs were determined and reported based on the clinical judgment of the investigator. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more symptomatic hypotension ECIs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Percentage of Participants Who Experienced One or More Anemia ECIs
Time Frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)
Anemia ECIs were determined and reported based on the clinical judgment of the investigator, regardless of etiology. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more anemia ECIs is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Merck Sharp & Dohme LLC

Investigators

  • Study Director: Medical Director, Merck Sharp & Dohme LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 2, 2021

Primary Completion (Actual)

November 20, 2024

Study Completion (Actual)

February 5, 2025

Study Registration Dates

First Submitted

October 18, 2021

First Submitted That Met QC Criteria

October 18, 2021

First Posted (Actual)

October 26, 2021

Study Record Updates

Last Update Posted (Estimated)

December 19, 2025

Last Update Submitted That Met QC Criteria

December 4, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1242-035
  • MK-1242-035 (Other Identifier: MSD)
  • 2022-500881-80-00 (Registry Identifier: EU CT)
  • 2020-005941-18 (EudraCT Number)
  • U1111-1278-5066 (Registry Identifier: UTN)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

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