To Study the Effects of Host Genetic Factors on Liver Cirrhosis
March 13, 2023 updated by: Ildar Fakhradiyev, Asfendiyarov Kazakh National Medical University
Preventive and Personalized Medicine (2021-2023)
The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis .
It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis .
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
1000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Almaty, Kazakhstan
- National Scientific Center of Surgery named after A.N. Syzganova
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 60 years (Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
KAZAKH POPULATION
Description
Inclusion Criteria:
- hepatitis B
Exclusion Criteria:
- the casual aget of liver disease is not viral infection, such as alcohol abuse
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Experimental group:
patients with liver cirrhosis
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SNP analysis of the DNA obtained from peripheral blood sample
|
|
Control group
patients without liver cirrhosis
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SNP analysis of the DNA obtained from peripheral blood sample
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
genotyping for the SNP associated with liver cirrhosis
Time Frame: 1 year
|
Genotype frequency of SNP in the study genes of participants and control participants.
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Bibigul Saparbekovna, PhD, JSC "National Scientific Center of Surgery named after A.N. Syzganova "
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 29, 2021
Primary Completion (Actual)
January 20, 2023
Study Completion (Actual)
January 20, 2023
Study Registration Dates
First Submitted
October 21, 2021
First Submitted That Met QC Criteria
October 26, 2021
First Posted (Actual)
October 27, 2021
Study Record Updates
Last Update Posted (Actual)
March 14, 2023
Last Update Submitted That Met QC Criteria
March 13, 2023
Last Verified
March 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1188
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.