Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection (SNP)

February 27, 2024 updated by: Hospices Civils de Lyon

Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.

Study Overview

Status

Recruiting

Conditions

Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis

Intervention / Treatment

Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.

Study Type

Interventional

Enrollment (Estimated)

3500

Phase

Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Jerome HONNORAT, Pr
Phone Number: +33 4 72 35 78 06
Email: jerome.honnorat@chu-lyon.fr

Study Contact Backup

Name: Geraldine PICARD
Phone Number: +33 4 72 35 58 42
Email: geraldine.picard@chu-lyon.fr

Study Locations

France
- - Aix-en-Provence, France, 13616
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Laurent MARTINEZ ALMOYNA, MD
      
      Phone Number: +33 04 42 33 50 71
      
      Email: lmartinezalmoyna@ch-aix.fr
    - Principal Investigator:
      
      Laurent MARTINEZ ALMOYNA, MD
  - Amiens, France, 80000
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Melanie BARBAY, MD
      
      Email: Barbay.melanie@chu-amiens.fr
    - Principal Investigator:
      
      Melanie BARBAY, MD
  - Angers, France, 49055
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Lila Autier, MD
      
      Email: Lila.Autier@ico.unicancer.fr
    - Principal Investigator:
      
      Lila Autier, MD
  - Annecy, France, 74370
    - Not yet recruiting
    - General Neurology
    - Contact:
      
      Déborah GROSSET JANIN, MD
      
      Email: dgrossetjanin@ch-annecygenevois.fr
    - Principal Investigator:
      
      Déborah GROSSET JANIN, MD
  - Avignon, France, 84000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Elodie BICILLI, MD
      
      Email: bicilli.elodie@ch-avignon.fr
    - Principal Investigator:
      
      Elodie BICILLI, md
  - Bayonne, France, 64100
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Olivier FLABEAU, MD
      
      Email: oflabeau@ch-cotebasque.fr
    - Principal Investigator:
      
      Olivier FLABEAU, MD
  - Besançon, France, 25056
    - Recruiting
    - Neurology
    - Contact:
      
      Nathalie Devys Meyer, MD
      
      Phone Number: 33 0381667391
      
      Email: nmeyer@chu-besancon.fr
    - Principal Investigator:
      
      Nathalie Devys Meyer, MD
  - Bobigny, France, 93000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Marie MONGIN, MD
    - Principal Investigator:
      
      Marie MONGIN, MD
  - Bordeaux, France, 33000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Frederic VILLEGA, MD
      
      Phone Number: 0556795626
      
      Email: frederic.villega@u-bordeaux.fr
    - Principal Investigator:
      
      Frederic VILLEGA, MD
  - Brest, France, 29200
    - Not yet recruiting
    - Neurology
    - Principal Investigator:
      
      Serge TIMSIT, MD
    - Contact:
      
      Serge TIMSIT, MD
      
      Phone Number: 33 02 98 34 76 20
      
      Email: serge.timsit@chu-brest.fr
  - Cannes, France, 06400
    - Not yet recruiting
    - Intensive Care Medicine
    - Contact:
      
      Raphaël CHAMBON, MD
      
      Email: r.chambon@ch-cannes.fr
    - Principal Investigator:
      
      CHAMBON Raphaël, MD
  - Chambéry, France, 73011
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Marie BARRE, MD
      
      Email: Marie.barre@ch-metropole-savoie.fr
    - Principal Investigator:
      
      Marie BARRE, MD
  - Clermont-Ferrand, France, 63003
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Eve CHANSON, MD
      
      Phone Number: +33 0473752200
      
      Email: echanson@chu-clermontferrand.fr
    - Principal Investigator:
      
      Eve CHANSON, MD
  - Colmar, France, 68000
    - Not yet recruiting
    - Neurologie
    - Principal Investigator:
      
      François SELLAL, MD
    - Contact:
      
      François SELLAL, md
      
      Phone Number: 33 0389124150
      
      Email: francois.sellal@ch-colmar.fr
  - Créteil, France, 94010
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Thierry GENDRE, MD
      
      Phone Number: 33 0149812303
      
      Email: Thierry.gendre@aphp.fr
    - Principal Investigator:
      
      Thierry GENDRE, MD
  - Dijon, France, 21231
    - Not yet recruiting
    - General, Vascular and Degenerative Neurology
    - Contact:
      
      Yannick BEJOT, MD
      
      Phone Number: 33 03 80 29 37 53
      
      Email: yannick.bejot@chu-dijon.fr
    - Principal Investigator:
      
      Yannick BEJOT, MD
  - Gap, France, 05000
    - Not yet recruiting
    - Internal and general practitioner
    - Contact:
      
      Thierry WEITTEN, MD
      
      Phone Number: 33 0492407680
    - Principal Investigator:
      
      WEITTEN Thierry, MD
  - Grenoble, France
    - Recruiting
    - Neurologie
    - Principal Investigator:
      
      Martial MALLARET, MD
    - Contact:
      
      Martial Mallaret, MD
      
      Email: MMallaret1@chu-grenoble.fr
  - La Roche-sur-Yon, France, 85925
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Nathalie TESTARD, MD
      
      Email: nathalie.testard@ght85.fr
    - Principal Investigator:
      
      Nathalie Testard, MD
  - Lille, France, 59000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Jean Paul NIGUET, MD
      
      Phone Number: 33 0320874901
      
      Email: niguet.jeanpaul@ghicl.net
    - Principal Investigator:
      
      Jean Paul Niguet, MD
  - Lille, France
    - Recruiting
    - Neurology
    - Contact:
      
      Tifanie ALBERTO, MD
      
      Email: tifanie.alberto@chu-lille.fr
    - Principal Investigator:
      
      Tifanie ALBERTO, MD
  - Limoges, France, 87042
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Laurent MAGY, MD
      
      Phone Number: 33 05 55 05 65 61
      
      Email: Leurent.magy@unilim.fr
    - Principal Investigator:
      
      Laurent MAGY, MD
  - Lisieux, France, 14100
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Doina CIOCANU, MD
      
      Phone Number: 33 0231613142
      
      Email: d.ciocanu@ch-lisieux.fr
    - Principal Investigator:
      
      Doina Ciocanu, MD
  - Lyon, France, 69677
    - Recruiting
    - Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites autoimmunes
    - Contact:
      
      Jerome HONNORAT, Pr
      
      Phone Number: +33 4 72 35 78 06
      
      Email: jerome.honnorat@chu-lyon.fr
    - Principal Investigator:
      
      Jerome HONNORAT, Pr
  - Marseille, France, 13005
    - Not yet recruiting
    - Adult Neurology and Neuropsychology
    - Contact:
      
      Elsa KAPHAN, MD
      
      Email: elsa.kaphan@ap-hm.fr
    - Principal Investigator:
      
      Elsa KAPHAN, MD
  - Marseille, France, 13385
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      MAAROUF Adil, MD
      
      Phone Number: +33 0491385939
      
      Email: Adil.maarouf@ap-hm.fr
    - Principal Investigator:
      
      MAAROUF Adil, MD
  - Marseille, France
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Hanna BOU ALI, MD
    - Principal Investigator:
      
      Hanna BOU ALI, MD
  - Metz, France, 57085
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Chrystel CHERAUD BONFORT, MD
      
      Email: c.cheraudbonfort@chr-metz-thioville.fr
    - Principal Investigator:
      
      Chrystel CHERAUD BONFORT, MD
  - Montivilliers, France, 76290
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Alexandre LECLANCHER, MD
      
      Phone Number: 33 0686497074
      
      Email: alexandre.leclancher@ch-havre.fr
    - Principal Investigator:
      
      Alexandre LECLANCHER, MD
  - Montpellier, France, 34295
    - Not yet recruiting
    - General Neurology
    - Contact:
      
      Mahmoud CHARIF, MD
      
      Email: m-charif@chu-montpellier.fr
    - Principal Investigator:
      
      Mahmoud CHARIF, MD
  - Mulhouse, France, 68070
    - Not yet recruiting
    - General medicine
    - Contact:
      
      Sohrab MOSTOUFIZADEH, md
      
      Phone Number: 33 0389646186
      
      Email: mostoufizadehs@ghrmsa.fr
    - Principal Investigator:
      
      Sohrab MOSTOUFIZADEH, MD
  - Mâcon, France, 71000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Patricia DEPIERRE, MD
      
      Email: padepierre@ch-macon.fr
    - Principal Investigator:
      
      Patricia DEPIERRE, MD
  - Nancy, France, 54035
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Louise TYVAERT, MD
      
      Phone Number: 03 83 85 85 85
      
      Email: l.tyvaert@chru-nancy.fr
    - Principal Investigator:
      
      Louise TYVAERT, MD
  - Nantes, France, 44093
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Hélène COURTEMANCHE, MD
      
      Phone Number: 33 02 40 16 52 12
      
      Email: helene.courtemanche@chu-nantes.fr
    - Principal Investigator:
      
      Hélène COURTEMANCHE, MD
  - Nice, France, 06000
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      BOURG Véronique, MD
      
      Phone Number: +33 04 92 03 82 80
      
      Email: Bourg.v@chu-nice.fr
    - Principal Investigator:
      
      BOURG Véronique, MD
  - Nîmes, France, 30029
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Giovanni CASTELNOVO
      
      Phone Number: 33 466683261
    - Principal Investigator:
      
      CASTELNOVO Giovanni, MD
  - Paris, France, 75014
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Clément VIALATTE DE PEMILLE, MD
      
      Email: cvialatte@ghpsj.fr
    - Principal Investigator:
      
      Clément VIALATTE DE PEMILLE, MD
  - Paris, France, 75015
    - Not yet recruiting
    - Neuropediatrics
    - Contact:
      
      Melodie AUBART, MD
      
      Email: melodie.aubart@aphp.fr
    - Principal Investigator:
      
      Melodie AUBART, MD
  - Paris, France, 75018
    - Not yet recruiting
    - Intensive Care Medicine
    - Contact:
      
      Romain SONNEVILLE, MD
      
      Phone Number: 33 0140256139
      
      Email: romain.sonneville@aphp.fr
    - Principal Investigator:
      
      Romain SONNEVILLE, MD
  - Paris, France, 75019
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Marine BOUDOT DE LA MOTTE, MD
      
      Phone Number: 33 01 48 03 68 52
      
      Email: mboudotdelamotte@for.paris
    - Principal Investigator:
      
      Marine Boudot de La Motte, MD
  - Paris, France, 75651
    - Not yet recruiting
    - Onco-neurology
    - Contact:
      
      Dimitri PSIMARAS, MD
      
      Phone Number: 33 0142160435
      
      Email: dimitri.psimaras@aphp.fr
    - Principal Investigator:
      
      Dimitri PSIMARAS, MD
  - Paris, France, 94275
    - Not yet recruiting
    - Neurology adult
    - Contact:
      
      Céline LABEYRIE, MD
      
      Phone Number: 33 01 45 21 26 18
      
      Email: celine.labeyrie@aphp.fr
    - Principal Investigator:
      
      Céline LABEYRIE, MD
  - Poitiers, France
    - Not yet recruiting
    - Neurology, neuropsychology and language rehabilitation
    - Contact:
      
      NEAU Jean-Philippe, MD
      
      Phone Number: +33 06 08 22 42 31
      
      Email: jph.neau@chu-poitiers.fr
    - Principal Investigator:
      
      NEAU Jean-Philippe, MD
  - Reims, France, 51100
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Maximilien MOULIN, MD
      
      Phone Number: 33 03 26 78 71 34
      
      Email: mmoulin@chu-reims.fr
    - Principal Investigator:
      
      Maximilien MOULIN, MD
  - Rennes, France, 35000
    - Not yet recruiting
    - Neurology
    - Principal Investigator:
      
      Anca NICA, MD
    - Contact:
      
      Anca NICA, MD
      
      Email: anca.nica@chu-rennes.fr
  - Rouen, France, 76038
    - Not yet recruiting
    - Vascular and general neurology
    - Contact:
      
      Benjamin HEBANT, MD
    - Principal Investigator:
      
      Benjamin HEBANT, MD
  - Saint-Brieuc, France, 22000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Olivier VERCRUYSSE, MD
    - Principal Investigator:
      
      Olivier VERCRUYSSE, MD
  - Saint-Denis, France, 93200
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Mickael BONNAN, MD
      
      Phone Number: 33 06 27 06 66 86
      
      Email: mickael_bonnan@yahoo.fr
    - Principal Investigator:
      
      Mickael BONNAN, MD
  - Saint-Malo, France, 35400
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Alexandre Bonnet, MD
      
      Email: a.bonnet@ch-stmalo.fr
    - Principal Investigator:
      
      Alexandre Bonnet, MD
  - Saint-Nazaire, France, 44600
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Lucie Metzger, MD
      
      Phone Number: 33 0272278229
      
      Email: l.metzger@ch-saintnzaire.fr
    - Principal Investigator:
      
      Lucie Metzger, MD
  - Saint-Étienne, France, 42055
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Jean-Philippe CAMDESSANCHÉ, MD
      
      Phone Number: 33 0477120559
      
      Email: j.philippe.camdessanche@chu-st-etienne.fr
    - Principal Investigator:
      
      Jean-Philippe CAMDESSANCHÉ, MD
  - Strasbourg, France, 67098
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Christine TRANCHANT, MD
      
      Phone Number: +33 03 88 12 85 32
      
      Email: Christine.Tranchant@chru-strasbourg.fr
    - Principal Investigator:
      
      Christine TRANCHANT, MD
  - Strasbourg, France, 67098
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Edouard HIRSCH, MD
      
      Phone Number: +33 03 88 12 85 62
      
      Email: edouard.hirsch@chru-strasbourg.fr
    - Principal Investigator:
      
      Edouard HIRSCH, MD
  - Suresnes, France, 92150
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Adrien WANG, MD
      
      Phone Number: 33 0146257343
      
      Email: a.wang@hopital-foch.com
    - Principal Investigator:
      
      Adrien WANG, MD
  - Toulon, France, 83100
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Elena-Camelia Rusu, MD
      
      Phone Number: 33 0616094863
      
      Email: Elena-camelia.rusu@ch-toulon.fr
    - Principal Investigator:
      
      Elena-Camelia RUSU, MD
  - Toulon, France, 83800
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Anthony FAIVRE, MD
      
      Phone Number: 33 0483162726
      
      Email: anthonyfa@wanadoo.fr
    - Principal Investigator:
      
      Anthony FAIVRE, MD
  - Tours, France, 37000
    - Not yet recruiting
    - Neurologie
    - Contact:
      
      Coline DUWICQUET, MD
      
      Phone Number: +33 06 89 11 48 31
      
      Email: c.duwicquet@chu-tours.fr
    - Principal Investigator:
      
      Coline DUWICQUET, MD
  - Valenciennes, France, 59300
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Marianne GIROUX, MD
      
      Email: giroux-m@ch-valenciennes.fr
    - Principal Investigator:
      
      Marianne GIROUX, MD
  - Vannes, France, 56000
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Benoit PEGAT, MD
      
      Email: benoit.pegat@ch-bretagne-atlantique.fr
    - Principal Investigator:
      
      Benoit PEGAT, MD
  - Versailles, France
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Jérôme SERVAN, MD
      
      Phone Number: 33 0139639147
      
      Email: jservan@ch-versailles.fr
    - Principal Investigator:
      
      Jérôme SERVAN, MD
  - Épinal, France, 88023
    - Recruiting
    - Neurology
    - Contact:
      
      Arnaud LARDIN, MD
      
      Phone Number: 33 03.29.68.71.04
      
      Email: arnaud.lardin@ch-ed.fr
    - Principal Investigator:
      
      Arnaud LARDIN, MD
- Guadeloupe
  - POINTE-à-pitre, Guadeloupe, France, 97159
    - Not yet recruiting
    - Neurology
    - Contact:
      
      Hugo CHAUMONT, MD
      
      Phone Number: 590 5 90 89 14 30
      
      Email: hugo.chaumont@chu-guadeloupe.fr
    - Principal Investigator:
      
      Hugo CHAUMONT, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Child
Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Patient with consent
Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
Patient with neurological disorder compatible with PNS or auto-immune encephalitis

Exclusion Criteria:

Refusal of consent
Patient under guardianship

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Other
Allocation: N/A
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Paraneoplastic neurological syndrome patients and autoimmune encephalitis patient patients with diagnosis of paraneoplastic neurological syndrome or autoimmune encephalitis	Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma. Blood is collected only one time by blood sample to obtain serum, buffy coat, plasma and PBMC. 2 4ml of blood on dry tube 2 4ml of blood on EDTA tube If possibility of delivery in 48 hours at the Centre of Biological Resources, 7*4ml of blood on heparin tube If cerebrospinal fluid has been drawn for diagnosis, remaining sample available will be stored in the collection

Participant Group / Arm

Intervention / Treatment

Other: Paraneoplastic neurological syndrome patients and autoimmune encephalitis patient

patients with diagnosis of paraneoplastic neurological syndrome or autoimmune encephalitis

Biological: Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.

Blood is collected only one time by blood sample to obtain serum, buffy coat, plasma and PBMC.

2 *4ml of blood on dry tube 2 *4ml of blood on EDTA tube If possibility of delivery in 48 hours at the Centre of Biological Resources, 7*4ml of blood on heparin tube If cerebrospinal fluid has been drawn for diagnosis, remaining sample available will be stored in the collection

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood Samples Time Frame: 10 years	Assessment of biocollection of blood samples	10 years
Cerebrospinal fluid biocollection Time Frame: 10 years	Assessment of biocollection of Cerebrospinal fluid	10 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Scientific collaboration Time Frame: 10 years	Number of project issued from the biocollection	10 years
Scientific Time Frame: 10 years	Number of scientific papers issued from the biocollection	10 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospices Civils de Lyon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 2, 2022

Primary Completion (Estimated)

August 2, 2032

Study Completion (Estimated)

August 2, 2032

Study Registration Dates

First Submitted

December 20, 2021

First Submitted That Met QC Criteria

January 6, 2022

First Posted (Actual)

January 20, 2022

Study Record Updates

Last Update Posted (Actual)

February 29, 2024

Last Update Submitted That Met QC Criteria

February 27, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

69HCL21_1271

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection (SNP)

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product