Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease (PREVAIL)

June 3, 2024 updated by: NewAmsterdam Pharma

Placebo Controlled, Double Blind, Randomized Cardiovascular Outcome Study to Evaluate the Effect of 10 mg Obicetrapib in Participants With ASCVD Not Adequately Controlled Despite Maximally Tolerated Lipid Modifying Therapies

This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with Atherosclerotic Cardiovascular Disease (ASCVD) who are not adequately controlled despite maximally tolerated lipid-lowering therapy.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

This study will be a placebo-controlled, double-blind, randomized, phase 3 study to evaluate the effect of 10mg Obicetrapib in participants with Atherosclerotic Cardiovascular Disease (ASCVD) who are not adequately controlled despite maximally tolerated lipid-lowering therapy to reduce the risk of cardiovascular death, myocardial infarction, stroke and non-elective coronary revascularization. The PREVAIL Study

Study Type

Interventional

Enrollment (Actual)

9541

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Australia
      • Adelaide, Australia
        • Royal Adelaide Hospital
      • Bedford Park, Australia, 5042
        • Flinders Medical Centre
      • Campbelltown, Australia
        • Campbelltown Hospital
      • Chermside, Australia, 4032
        • The Prince Charles Hospital
      • Clayton, Australia, 3168
        • Monash Health
      • Halls Creek, Australia, 6210
        • Bridge Family Practice
      • Heidelberg, Australia, 3084
        • Austin Health
      • Melbourne, Australia
        • The Alfred Hospital
      • Melbourne, Australia, VIC 3004
        • Baker Heart and Diabetes Institute
      • Redcliffe, Australia, 4020
        • Redcliffe Hospital
      • Saint Albans, Australia, VIC 3021
        • Western Health
      • Southport, Australia, 4222
        • Griffith University
      • Wollongong, Australia, 2500
        • Wollongong Hospital (Illawarra Shoalhaven Local Health District)
      • Woodville South, Australia
        • The Queen Elizabeth Hospital (TQEH) - SA Health
      • Woolloongabba, Australia, 4102
        • Dr Heart Pty Ltd at Cholesterol Care Australia
  • Bulgaria
      • Aytos, Bulgaria, 8500
        • MHAT Aytos EOOD Department of Internal Diseases
      • Burgas, Bulgaria, 8000
        • Medical Center Doctor Staykov EOOD
      • Burgas, Bulgaria
        • UMHAT Deva Maria
      • Dobrich, Bulgaria, 9300
        • Medical Center Viva Feniks
      • Gorna Oryahovitsa, Bulgaria, 5100
        • MHAT Sveti Ivan Rilski
      • Haskovo, Bulgaria, 6300
        • MHAT Haskovo AD
      • Montana, Bulgaria, 3400
        • MHAT City Clinic - Sveti Georgi EOOD
      • Pleven, Bulgaria, 5800
        • Medical Center - Cordis OOD
      • Pleven, Bulgaria, 5800
        • MHAT Heart and Brain Pleven
      • Plovdiv, Bulgaria, 4002
        • Medical Center for Rehabilitation and Sports Medicine I - Plovdiv EOOD
      • Plovdiv, Bulgaria, 4002
        • UMHAT Sveti Georgi EA
      • Ruse, Bulgaria, 7013
        • SHATC Medica Cor EAD
      • Ruse, Bulgaria, 7000
        • Medical Center Rusemed EOOD
      • Silistra, Bulgaria
        • Multiprofile Hospital for Active Treatment (MHAT)- Silistra
      • Sliven, Bulgaria, 8800
        • MHAT Dr. Ivan Seliminski AD
      • Sofia, Bulgaria, 1000
        • Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD
      • Sofia, Bulgaria, 1700
        • MC Doctor Kalchev OOD
      • Sofia, Bulgaria, 1000
        • MHAT Sveta Sofia EOOD
      • Sofia, Bulgaria, 1113
        • Diagnostic and Consulting Center 22 - Sofia
      • Sofia, Bulgaria, 1202
        • DCC "Ascendent"
      • Sofia, Bulgaria, 1231
        • Diagnostic consultative center 24
      • Sofia, Bulgaria, 1233
        • National Multiprofile Transport Hospital Tsar Boris Treti - Cardiology Clinic
      • Sofia, Bulgaria, 1309
        • Medical Centre Medcross
      • Sofia, Bulgaria, 1680
        • Diagnostic Consulting Center Convex EOOD
      • Sofia, Bulgaria
        • "Medical Center Medic" OOD
      • Sofia, Bulgaria
        • Multiprofile Hospital for Active Treatment National Cardiology Hospital
      • Stara Zagora, Bulgaria, 6000
        • CardioArt Medical Center
      • Stara Zagora, Bulgaria, 6003
        • UMHAT Prof. Dr. Stoyan Kirkovich
      • Stara Zagora, Bulgaria, 6003
        • Medical Center Zara - Med
      • Varna, Bulgaria, 9020
        • Specialized Hospital for Active Treatment of Cardiology
      • Varna, Bulgaria, 9000
        • Diagnostic Consultative Center Chaika
      • Varna, Bulgaria, 9000
        • Medical Center Plazmamed Clinic
      • Veliko Tarnovo, Bulgaria, 5006
        • Medical Center Medica Plus OOD
      • Veliko Tarnovo, Bulgaria
        • Medical Center Nevromedics
      • Velingrad, Bulgaria, 4600
        • Medical Center Velingrad 2017 EOOD
  • Canada
      • Brampton, Canada
        • Brampton Clinical Trials
      • Laval, Canada
        • Centre de Recherche Clinique de Laval
      • Mississauga, Canada
        • KMH Cardiology & Diagnostic Centres - Mississauga
      • Quebec, Canada
        • Institut Universitaire de Cardiologie et de Pneumologie de Québec
      • Victoria, Canada
        • Discovery Clinical Services, Ltd
    • British Columbia
      • Kamloops, British Columbia, Canada, V2C 5T1
        • Medical Arts Health Research Group - Kamloops
      • North Vancouver, British Columbia, Canada, V7M 2H4
        • Medical Arts Health Research Group - North Vancouver
      • Penticton, British Columbia, Canada, V2A 5L5
        • The Medical Arts Health Research Group - Penticton
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3C 0N2
        • Winnipeg Clinic
    • Ontario
      • Concord, Ontario, Canada, L4K 4M2
        • LMC Diabetes & Endocrinology Ltd. - Thornhill
      • Oshawa, Ontario, Canada, L1J2K1
        • Dr. James Cha
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials
      • Stoney Creek, Ontario, Canada, L8J 3W2
        • KMH Cardiology & Diagnostic Centres - Hamilton
    • Quebec
      • Chicoutimi, Quebec, Canada, G7H 7K9
        • Ecogene-21
      • Saint-Jean-sur-Richelieu, Quebec, Canada, J3A 1J2
        • CardioVasc HR
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Estrie -Centre hospitalier universitaire de Sherbrooke (CHUS)
      • Trois-Rivières, Quebec, Canada, G9A 4P3
        • Diex Recherche Trois-Rivieres, Inc
      • Victoriaville, Quebec, Canada, G6P 6P6
        • Diex Recherche Victoriaville
  • China
      • Beijing, China, 100034
        • Peking University First Hospital
      • Bengbu, China, 233017
        • The First Affiliated Hospital of Bengbu Medical College
      • Changde, China, 415003
        • The First People's Hospital of Changde City
      • Changzhou, China, 213164
        • The Second People's Hospital of Changzhou
      • Chifeng, China, 24050
        • Affiliated Hospital of Chifeng University
      • Daqing, China, 163711
        • Daqing People's Hospital
      • Foshan, China, 528308
        • Shunde Hospital of Southern Medical University
      • Guangzhou, China, 510080
        • Guangdong Provincial People's Hospital
      • Harbin, China, 150036
        • Heilongjiang Provincial Hospital
      • Nanyang, China, 473024
        • The First Affiliated Hospital of Nanyang Medical College
      • Nanyang, China, 473024
        • The First Affiliated Hospital of Nanyang Medical College - 2nd site
      • Ningbo, China, 315010
        • Ningbo first hospital
      • Panjin, China, 124010
        • Panjin Liaoyou Gem Flower Hospital
      • Pingxiang, China, 337055
        • Pingxiang People's Hospital
      • Tianjin, China, 300143
        • Tianjin Fourth Central Hospital
      • Tianjin, China, 300121
        • People's Hospital of Tianjin
      • Xi'an, China, 710075
        • Xi'an Gaoxin Hospital
      • Xianyang, China, 712099
        • Xianyang Hospital of Yan 'an University
      • Xinxiang, China, 453000
        • The Third Affiliatied Hospital of Xinxiang Medical University
      • Zibo, China, 255499
        • Zibo City Linzi District People's Hospital
  • Croatia
      • Karlovac, Croatia, 47000
        • General Hospital Karlovac
      • Krapinske Toplice, Croatia, 49217
        • Special Hospital for Medical Rehabilitation Krapinske Toplice
      • Slavonski Brod, Croatia, 35000
        • General Hospital Dr Josip Bencevic
      • Zagreb, Croatia, 10000
        • University Hospital Center Zagreb
      • Zagreb, Croatia, 10000
        • Polyclinic Solmed
  • Czechia
      • Brandýs Nad Labem, Czechia, 250 01
        • Medicus Services SRO
      • Brno, Czechia, 612 00
        • Kardiologicka ambulance Brno s.r.o.
      • Brno, Czechia, 60300
        • Centrum pro zdravi - kardiologie s.r.o.
      • Brno, Czechia
        • Amkardia sro
      • Bílina, Czechia, 41801
        • Hornicka nemocnice s poliklinikou Bilina s.r.o.
      • Havlickuv Brod, Czechia
        • Nemocnice Havlickuv Brod, p.o.
      • Hodonin, Czechia
        • Cevni ambulance - MATMED s.r.o.
      • Krnov, Czechia
        • MUDr. Tomas Edelsberger - diabetologicka ambulance
      • Kroměříž, Czechia, 767 01
        • Lunacor s.r.o. - Centrum pro choroby srdce a cev
      • Liberec, Czechia, 46014
        • KARDIOLOGIE - LIBEREC s.r.o.
      • Mariánské Lázně, Czechia, 353 01
        • InterKardio ML s.r.o.
      • Náchod, Czechia, 551 01
        • EDUMED s.r.o.
      • Olomouc, Czechia, 779 00
        • PreventaMed s.r.o.
      • Ostrava, Czechia, 702 00
        • CCR Ostrava s.r.o.
      • Otrokovice, Czechia, 765 02
        • Lunacor, s.r.o. - Centrum pro choroby srdce a cev - Otrokovice
      • Prague, Czechia, 106 00
        • Kardiologie COR s.r.o.
      • Prague, Czechia, 169 02
        • Ustredni vojenska nemocnice
      • Praha, Czechia, 15006
        • Fakultni nemocnice v Motole
      • Praha, Czechia, 128 08
        • Vseobecna fakultni nemocnice v Praze
      • Zlín, Czechia, 762 75
        • Krajska nemocnice T. Bati
  • Denmark
      • Aalborg, Denmark, 9000
        • Aalborg University Hospital
      • Copenhagen, Denmark, 2300
        • Amager Hospital
      • Esbjerg, Denmark, 6700
        • Sydvestjysk Hospital
      • Herning, Denmark, 7400
        • Godstrup Regional Hospital (Gødstrup)
      • Kobenhavn, Denmark, 2000
        • Bispebjerg Hospital
      • Viborg, Denmark, 8800
        • Viborg Regional Hospital
  • Finland
      • Jyväskylä, Finland, 40620
        • StudyCor Oy
      • Kuopio, Finland
        • Satucon Oy Kuopio
      • Turku, Finland, 20521
        • Turku University Hospital
  • Georgia
      • Batumi, Georgia
        • Health Ltd
      • Batumi, Georgia
        • JSC Evex Hospitals - Batumi Referral Hospital
      • Kutaisi, Georgia
        • Kutaisi Primary Health Care Center #1
      • Tbilisi, Georgia
        • Emergency Cardiology Center by Academician G. Chapidze Ltd
      • Tbilisi, Georgia
        • Tbilisi Heart and Vascular Clinic Ltd
      • Tbilisi, Georgia
        • Bokhua Memorial Cardiovascular Center LTD
      • Tbilisi, Georgia
        • Cardioclinic Digomi Medical Center-
      • Tbilisi, Georgia
        • David Metreveli Medical Centre Lt
      • Tbilisi, Georgia
        • JSC Curatio
      • Tbilisi, Georgia
        • LTD Adapti
      • Tbilisi, Georgia
        • LTD Georgian-Dutch Hospital
      • Tbilisi, Georgia
        • LTD Israeli -Georgian Medical Research Clinic Healthycore
      • Tbilisi, Georgia
        • Ltd Tbilisi Heart Center
      • Tbilisi, Georgia
        • LTD Vitamed
      • Tbilisi, Georgia
        • Mediclub Georgia
      • Tbilisi, Georgia
        • Multiprofile Clinic Consilium Medulla LTD
      • Tbilisi, Georgia
        • National Center for Diabetes Research
      • Tbilisi, Georgia
        • The First Medical Center LTD
      • Tbilisi, Georgia
        • VivaMedi
  • Germany
      • Bad Homburg, Germany
        • Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair
      • Berlin, Germany, 13187
        • Diabetespraxis Dr. Braun
      • Berlin, Germany, 10117
        • kfgn | Site Operations & Services GmbH - Berlin-Mitte
      • Berlin, Germany, 10787
        • Franziskus Hospital Berlin
      • Bremen, Germany
        • Kardiologisch-Angiologische Praxis - Herzzentrum Bremen
      • Chemnitz, Germany
        • MVZ am Küchwald GmbH
      • Dortmund, Germany
        • Gemeinschaftspraxis Diabeteszentrum Dortmund
      • Dortmund, Germany
        • St Johannes Hospital Dortmund
      • Dresden, Germany
        • Universitaetsklinikum Carl Gustav Carus Dresden
      • Dresden, Germany, 1069
        • Kfgn | Site Operations & Services GmbH - Dresden
      • Elsterwerda, Germany, 4910
        • ZKS - Zentrum Klinische Studien Sudbrandenburg GmbH
      • Erfurt, Germany
        • Katholisches Krankenhaus St. Johann Nepomuk
      • Essen, Germany
        • Klinisches Forschungszentrum Dr. Hagemann
      • Essen, Germany
        • Studienzentrum Bocholderstrasse
      • Falkensee, Germany
        • Zentrum für Klinische Studien (diabetes-falkensee.de)
      • Frankfurt, Germany, 60596
        • ClinPhenomics CVC GmbH
      • Hamburg, Germany
        • Diabeteszentrum Hamburg West (DZHW) / Gemeinschaftspraxis Dr. Wendisch, Dr. Dahl und Prof. Dr. Aberle
      • Heidelberg, Germany, 69115
        • St. Josefskrankenhaus Heidelberg GmbH
      • Kiel, Germany, 24105
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel
      • Leipzig, Germany, 4103
        • Velocity Clinical Research Leipzig GmbH
      • Ludwigshafen, Germany
        • Diabetologikum DDG Ludwigshafe
      • Monchengladbach, Germany, 41063
        • Kliniken Maria Hilf GmbH Krankenhaus St. Franziskus
      • München, Germany
        • CDG Studienambulanz Dr. Hartard
      • München, Germany
        • Klinikum München Klinik Neuperlach
      • Nuernberg, Germany
        • Praxis Drs. Haggenmiller/Jeserich
      • Oldenburg In Holstein, Germany, 23758
        • RED-Institut GmbH
      • Reinfeld, Germany
        • Praxis Reinfeld Mitte
      • Rotenburg, Germany, 36199
        • Herz Kreislauf Zentrum - Klinikum Hersfeld Rotenburg GmbH
      • Stuhr, Germany
        • Studienzentrum Brinkum
      • Wallerfing, Germany
        • Gemeinschaftspraxis Dr. med. Josef und Dr. med. Wilma Grosskopf
      • Witten, Germany, 58455
        • Forschungszentrum Ruhr
      • Zwenkau, Germany, 4442
        • INFO-MED Leipzig GmbH
  • Hungary
      • Baja, Hungary
        • Lausmed Kft
      • Balatonfüred, Hungary, 8230
        • Tagore Medical Center
      • Budapest, Hungary, H-1122
        • Semmelweis Egyetem - Varosmajori Sziv es Ergyogyaszati Klinika
      • Budapest, Hungary, 1036
        • Qualiclinic Kft
      • Budapest, Hungary
        • Clinexpert Kft.
      • Budapest, Hungary, 1097
        • Dél-Pesti Centrumkórház
      • Budapest, Hungary, 1132
        • Med-Tima Kft
      • Budapest, Hungary, 1085
        • Semmelweis Egyetem - Szent Rokus Klinikai Tomb
      • Budapest, Hungary, H-1036
        • Obudai Egeszsegugyi Centrum - Budapest
      • Budapest, Hungary
        • High Tech Medical Kft
      • Békéscsaba, Hungary, 5600
        • Dr Lakatos Ferenc Belgyogyaszati-Kardiologiai Maganrendelo
      • Debrecen, Hungary, 4025
        • Belinus Bt
      • Encs, Hungary, H-3860
        • CRU Hungary Kft.
      • Gyongyos, Hungary
        • Pharma4 Trial Kft
      • Hatvan, Hungary, 3000
        • BKS Research Kft.
      • Hodmezovasarhely, Hungary
        • Porcika Klinik
      • Kaposvar, Hungary
        • Somogy Varmegyei Kaposi Mor Oktato Korhaz
      • Kistarcsa, Hungary, H- 2143
        • Pest M. Flór F. Kórház V. Belgy. Oszt
      • Kistarcsa, Hungary
        • Kistarcsai Flor Ferenc Korhaz
      • Miskolc, Hungary
        • IPR Hungary Kft
      • Nyiregyhaza, Hungary, H-4400
        • Medifarma-98 Kft
      • Nyíregyháza, Hungary, 4405
        • dr Vasas Szilard Haziorvosi Rendelo
      • Orosháza, Hungary, 5900
        • dr Nagy Laszlo Kardiologiai Maganrendeles es Klinikai Vizsgalohely
      • Pecs, Hungary
        • Coromed Smo Kft
      • Zalaegerszeg, Hungary, 8900
        • Óbudai Egészségügyi Centrum - Zalaegerszeg
  • Israel
      • Ashkelon, Israel, 7830604
        • Barzilai Medical Center
      • Haifa, Israel, 3109601
        • Rambam Health Care Campus
      • Haifa, Israel, 3436212
        • The Lady Davis Carmel Medical Center
      • Haifa, Israel, 3104802
        • Bnai Zion Medical Center
      • Jerusalem, Israel, 9103102
        • Shaare Zedek Medical Center
      • Jerusalem, Israel, 9112001
        • Hadassah Hebrew University Medical Center - Cardiology - The Heart Institute
      • Kfar Saba, Israel, 44281
        • Meir Medical Center
      • Nahariyya, Israel, 2210001
        • Galilee Medical Cente
      • Petach Tikva, Israel, 4941492
        • Rabin Medical Center, Beilinson Hospital - Internal Medicine B
      • Petach Tikva, Israel, 4941492
        • Rabin Medical Center, Beilinson Hospital
      • Poriyya, Israel, 1520800
        • The BARUCH PADEH Medical Center, Poriya
      • Reẖovot, Israel, 7610001
        • Kaplan Medical Center
      • Safed, Israel, 1340305
        • Ziv Medical Center
      • Zerifin, Israel, 6093000
        • Shamir Medical Center (Assaf Harofeh)
  • Italy
      • Ferrara, Italy
        • Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna
      • Milano, Italy
        • IRCCS Ospedale San Raffaele
      • Napoli, Italy
        • Azienda Ospedaliera Universitaria Federico II
      • Palermo, Italy, 90127
        • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
      • Pavia, Italy, 27100
        • Fondazione IRCCS Policlinico San Matteo
      • Rozzano, Italy
        • Istituto Clinico Humanitas
      • Terni, Italy
        • Azienda Ospedaliera Santa Maria di Terni
  • Japan
      • Chiba, Japan, 260-8677
        • Chiba University Hospital
      • Chiba, Japan, 271-0077
        • New Tokyo Heart Clinic
      • Fukuoka, Japan, 802-8555
        • Kokura Memorial Hospital
      • Fukuoka, Japan, 806-8501
        • Japan Community Health Care Organization Kyushu Hospital
      • Gunma, Japan, 370-0829
        • National Hospital Organization Takasaki General Medical Center
      • Hiroshima, Japan, 734-8551
        • Hiroshima University Hospital
      • Hiroshima, Japan, 734-8530
        • Hiroshima Prefectural Hospital
      • Hyōgo, Japan, 670-8560
        • Hyogo Prefectural Harima-Himeji General Medical Center
      • Ishikawa, Japan, 920-8530
        • Ishikawa Prefectural Central Hospital
      • Ishikawa, Japan, 923-8560
        • Komatsu Municipal Hospital
      • Ishikawa, Japan, 924-8588
        • Public Central Hospital of Matto lshikawa
      • Kanagawa, Japan, 224-8503
        • Showa University Northern Yokohama Hospital
      • Kanagawa, Japan, 236-0037
        • Yokohama Minami Kyousai Hospital
      • Niigata, Japan, 951-8510
        • Niigata University Medical & Dental Hospital
      • Okayama, Japan, 700-0804
        • The Sakakibara Heart Institute of Okayama
      • Osaka, Japan, 530-0001
        • Sakurabashi Watanabe Hospital
      • Osaka, Japan, 565-8565
        • National Cerebral and Cardiovascular Center Research Institute
      • Osaka, Japan, 569-8686
        • Osaka Medical and Pharmaceutical University Hospital
      • Osaka, Japan, 565-0862
        • Saiseikai Senri Hospital
      • Tokyo, Japan, 173-8610
        • Nihon University Itabashi Hospital
      • Tokyo, Japan, 108-0073
        • Tokyo Saiseikai Central Hospital
  • Jordan
      • Amman, Jordan
        • Istishari Hospital
      • Amman, Jordan
        • Abdali Hospital
      • Irbid, Jordan
        • Irbid Specialty Hospital
      • Irbid, Jordan
        • Pharmaceutical Research Center -Jordan University of Science & Technology/King Abdulla University Hospital - Cardiology
  • Latvia
      • Daugavpils, Latvia, 5417
        • Latgales Medical Center
      • Daugavpils, Latvia
        • SIA ANIO
      • Liepaja, Latvia
        • D. Saulites-Kandevicas Private Practice
      • Riga, Latvia, 1002
        • Pauls Stradins Clinical University Hospital Riga
      • Valmiera, Latvia, 4201
        • Vidzemes Hospital
  • Netherlands
      • Amsterdam, Netherlands, 1105AZ
        • Academic Medical Center - Department of Vascular Medicine
      • Arnhem, Netherlands, 6815 AD
        • Ziekenhuis Rijnstate
      • Beverwijk, Netherlands, 1942 LE
        • Rode Kruis Ziekenhuis
      • Delft, Netherlands, 2625 AD
        • Reinier de Graaf Gasthuis
      • Den Haag, Netherlands, 2512 VA
        • HMC Westeinde
      • Dirksland, Netherlands, 3247 BW
        • Het Van Weel-Bethesda Ziekenhuis
      • Dordrecht, Netherlands, 3331 LZ
        • Albert Schweitzer Ziekenhuis - Location Dordrecht
      • Ede, Netherlands, 6716 RP
        • Ziekenhuis Gelderse Vallei
      • Eindhoven, Netherlands, 5504 DB
        • Maxima Medisch Centrum
      • Gouda, Netherlands, 2803 HH
        • Groene Hart Ziekenhuis
      • Harderwijk, Netherlands, 3844 DG
        • St. Jansdal Ziekenhuis
      • Helmond, Netherlands, 5707 HA
        • Elkerliek Ziekenhuis - Locatie Helmond
      • Hoogeveen, Netherlands, 7827
        • Treant Zorggroep
      • Leiden, Netherlands, 2333 ZA
        • Leids Universitair Medisch Centrum
      • Nijmegen, Netherlands, 6532 SZ
        • Canisius-Wilhelmina Ziekenhuis (CWZ)
      • Nijmegen, Netherlands, 6525 GA
        • Stichting Radboud Universitair Medisch Centrum
      • Rotterdam, Netherlands, PM 3045
        • Franciscus Gasthuis & Vlietland - Locatie Gasthuis
      • Utrecht, Netherlands, 3582 KE
        • Diakonessenhuis - Locatie Utrecht
      • Venlo, Netherlands, 5912 BL
        • VieCuri Medisch Centrum
      • Zaandam, Netherlands, 1502 DV
        • Zaans Medisch Centrum
      • Zwijndrecht, Netherlands, 3331 LZ
        • Albert Schweitzer Ziekenhuis - Location Zwijndrecht
  • Poland
      • Bydgoszcz, Poland, 85-796
        • Centrum Medyczne Pratia Bydgoszcz
      • Bydgoszcz, Poland, 85-605
        • Centrum Medyczne Intercor Sp. z o.o.
      • Bydgoszcz, Poland, 85231
        • Centrum Medyczne Kermed - Renata Bijata-Bronisz I Ewa Kowalinska Spólka Jawna
      • Chorzów, Poland, 41-500
        • DIAB Serwis Popenda Spólka Jawna
      • Elbląg, Poland, 82-300
        • NZOZ Twoje Zdrowie EL Sp. z o.o.
      • Gdansk, Poland
        • Uniwersyteckie Centrum Kliniczne, I Klinika Kardiologii
      • Gdańsk, Poland, 80-262
        • Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Adam Grzybowski
      • Gdynia, Poland, 81-157
        • Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii, lek. med. Krzysztof Cymerman
      • Grodzisk Mazowiecki, Poland
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II
      • Katowice, Poland, 40-081
        • Centrum Medyczne Pratia Katowice
      • Katowice, Poland
        • Silmedic Sp. z o.o.
      • Katowice, Poland, 40-675
        • SALVIA Lekston i Madej s.j.
      • Krakow, Poland, 30-510
        • Pratia MCM Krakow
      • Krakow, Poland, 30-082
        • Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
      • Kraków, Poland, 31-501
        • Krakowskie Centrum Medyczne Sp. z o.o.
      • Kraków, Poland, 31-216
        • Centrum Medyczne Zdrowa
      • Kraków, Poland, 31-202
        • Krakowski Szpital Specjalistyczny im. Jana Pawla II - Oddzial Kliniczny Kardiologii Interwencyjnej z Pododdzialem Intenyswengo Nadzoru Kardiologicznego
      • Lublin, Poland, 20-078
        • Clinical Best Solutions - Lublin
      • Lublin, Poland, 20-362
        • KO - MED Centra Kliniczne Lublin II
      • Lublin, Poland, 20-412
        • ETG Lublin - Pro Life Medica Sp. z o.o
      • Miechów, Poland, 32-086
        • Szpital Sw. Anny w Miechowie
      • Mragowo, Poland
        • Pomorskie Centra Kardiologiczne Sp. z o.o., SKA - Mragowo
      • Olsztyn, Poland, 10-010
        • FutureMeds Olsztyn
      • Ostrowiec Swietokrzyski, Poland
        • Ostrowieckie Centrum Medyczne spólka cywilna Anna Olech-Cudzik
      • Oława, Poland, 55-200
        • ZOZ w Olawie, Oddzial Chorob Wewnetrznych
      • Poznan, Poland, 60-111
        • Centrum Medyczne OMEDICA Jaroslaw Opiela i Beata Opiela s. j.
      • Poznań, Poland, 61-853
        • NZOZ Neuro-Kard - Ilkowski i Partnerzy Spólka Partnerska Lekarzy
      • Ruda Śląska, Poland, 41-710
        • Aka-Med Centrum Spólka Z Ograniczona Odpowiedzialnoscia
      • Siedlce, Poland, 08-110
        • ETG Siedlce- Lukmed 2 Sp. z o.o.
      • Skierniewice, Poland, 96-100
        • ETG Skierniewice - ClinMedica Research Sp. z o.o.
      • Sopot, Poland, 81-423
        • NZOZ PRO CORDIS Sopockie Centrum Badan Kardiologicznych
      • Staszów, Poland
        • Nowe Zdrowie-Ck Kieltucki i Wspolnicy Spolka Jawna
      • Szczecin, Poland, 71-526
        • Osrodek Badan Klinicznych LabMed Agnieszka Karczmarczyk, Filip Karczmarczyk Spólka Cywilna
      • Toruń, Poland, 87-100
        • Prywatny Gabinet Lekarski Jacek Gessek
      • Warsaw, Poland, 02-793
        • ETG Warszawa- MCM Polimedica 2 Sp. z o.o.
      • Warszawa, Poland, 00-215
        • FutureMeds Warszawa Centrum
      • Warszawa, Poland, 03-291
        • FutureMeds Targowek
      • Warszawa, Poland
        • Clinical Best Solutions Sp. z.o.o Spolka Komandytowa
      • Warszawa, Poland
        • Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy, Poradnia Prewencji i Leczenia Chorob Metabolicznych, Zaklad Epidemiologii, Prewencji Chorób Ukladu Krazeni
      • Wrocław, Poland, 50-981
        • 4 Wojskowy Szpital Kliniczny z Poliklinika Samodzielny Publiczny ZOZ we Wroclawiu
      • Wrocław, Poland, 50-088
        • FutureMeds Sp. z o.o
      • Wrocław, Poland, 53-149
        • Wroclawska Grupa Medyczna Pankiewicz Spolka Jawna
      • Zamosc, Poland, 22 - 400
        • ETG Zamosc - Pro Life Medica Sp. z o.o
      • Zamość, Poland, 22-400
        • KO - MED Centra Kliniczne Sp. z o.o., Osrodek Badan Klinicznych w Zamosciu
      • Łódź, Poland, 91-363
        • FutureMeds Lodz
      • Łódź, Poland, 93-338
        • INSTYTUT CENTRUM ZDROWIA MATKI POLKI - Klinika Kardiologii i Wad Wrodzonych Doroslych
      • Łódź, Poland, 90-302
        • ETG Lodz - Santa Sp. z. o.o.
      • Łódź, Poland, 94-255
        • Indywidualna Specjalistyczna Praktyka Lekarska Wlodzimierz Kus
  • Slovakia
      • Banská Bystrica, Slovakia, 974 01
        • Stredoslovensky ustav srdcovych a cievnych chorob, a.s.
      • Bardejov, Slovakia, 085 01
        • Alian, s.r.o., Kardiologicka ambulancia
      • Bardejov, Slovakia, 085 01
        • DIADA s.r.o.
      • Bardejov, Slovakia
        • Thyreomedical s.r.o.
      • Bratislava, Slovakia
        • Univerzitna nemocnica Bratislava
      • Bratislava, Slovakia
        • Medispektrum s.r.o., Diabetologicka a metabolicka ambulancia
      • Brezno, Slovakia, 977 01
        • Kardiologicka ambulancia NsP, n.o.
      • Dolny Kubin, Slovakia
        • JM-INTERNA, s.r.o., Ambulancia vnutorneho lekarstva
      • Kosice, Slovakia, 4001
        • Human-Care s.r.o
      • Kosice, Slovakia, 4001
        • Medical group Kosice, s.r.o. - Kardiologicka a Interna ambulancia
      • Košice, Slovakia, 040 22
        • Cardio D&R, S.R.O. Kosice
      • Levoča, Slovakia, 054 01
        • KardioLEV s. r. o.
      • Lucenec, Slovakia, 98401
        • Kardio 1 S.R.O.
      • Lucenec, Slovakia
        • Interna a diabetologicka ambulancia - IN - DIA s.r.o., MUDr. Livia Tomasova
      • Lučenec, Slovakia, 984 01
        • Kardiomed s.r.o.
      • Martin, Slovakia
        • Univerzitna nemocnica Martin
      • Moldava nad Bodvou, Slovakia
        • Medi M and M sro
      • Nitra, Slovakia, 949 01
        • Kardiocentrum Nitra s.r.o.
      • Piešťany, Slovakia, 92101
        • Medical KG, s.r.o. - Ambulancia vnutorneho lekarstva
      • Presov, Slovakia
        • Medispol, s.r.o.
      • Roznava, Slovakia
        • Tatratrial s.r.o
      • Svidník, Slovakia, 8901
        • Interna SK, s.r.o., Kardiologicka a interna ambulancia
      • Trnava, Slovakia, 917 01
        • JAL s.r.o.
      • Žilina, Slovakia, 1001
        • Medivasa, s.r.o., Angiologicka a kardiologicka ambulancia
  • South Africa
      • Bloemfontein, South Africa
        • Iatros International
      • Cape Town, South Africa
        • Tiervlei Trial Centre (TTC)
      • Cape Town, South Africa
        • TREAD Research - Department of Cardiology
      • Johannesburg, South Africa, 2013
        • WCR - Bara Cardiology
      • Somerset West, South Africa
        • Dr JM Engelbrecht Trial Site
      • Somerset West, South Africa
        • Helderberg Research Institute
      • Tongaat, South Africa
        • Mediclinic Victoria
  • Spain
      • A Coruna, Spain
        • Hospital Universitario de A Coruña
      • Alicante, Spain
        • Hospital General Universitario de Alicante Dr. Balmis
      • Almeria, Spain
        • Hospital Universitario Torrecárdenas
      • Barcelona, Spain
        • Hospital del Mar
      • Barcelona, Spain
        • Hospital Universitari de Bellvitge
      • Barcelona, Spain
        • Hospital Universitario Vall d'Hebron
      • Córdoba, Spain
        • Hospital Universitario Reina Sofia
      • Granada, Spain
        • Hospital Universitario Virgen de las Nieves
      • Madrid, Spain
        • Hospital General Universitario Gregorio Marañon
      • Malaga, Spain
        • Hospital Universitario Virgen de la Victoria
      • Santiago de Compostela, Spain
        • Hospital Clínico Universitario de Santiago
      • Sevilla, Spain
        • Hospital Universitario Virgen Macarena
      • Tarragona, Spain
        • Hospital Universitario Joan XXIII de Tarragona
      • Valencia, Spain
        • Hospital Clinico Universitario de Valencia
      • Vigo, Spain
        • Hospital Alvaro Cunqueiro
      • Zaragoza, Spain
        • Hospital Universitario Miguel Servet
  • United Kingdom
      • Belfast, United Kingdom
        • Ulster Hospital
      • Birmingham, United Kingdom, B9 5SS
        • Birmingham Heartlands Hospital
      • Birmingham, United Kingdom, B21 9RY
        • FutureMeds - Soho Road Health Centre
      • Blackpool, United Kingdom, FY4 3AD
        • Waterloo Medical Centre
      • Cardiff, United Kingdom, CF14 4XW
        • University Hospital of Wales
      • Cardiff, United Kingdom, CF5 4AD
        • FutureMeds - Ely Bridge Surgery
      • Durham, United Kingdom, DL3 6HX
        • Darlington Memorial Hospital
      • Enfield Town, United Kingdom, EN3 4GS
        • Panthera - London North
      • Fowey, United Kingdom, PL23 1DT
        • Fowey River Practice
      • Glasgow, United Kingdom, G51 4LB
        • Panthera - Glasgow
      • Glasgow, United Kingdom
        • Futuremeds - CPS Research
      • Hounslow, United Kingdom, TW3 3ET
        • Hounslow Medical Centre
      • London, United Kingdom, EC1M 6BQ
        • St. Bartholomew's Hospital
      • London, United Kingdom, SW10 0LR
        • The Good Practice
      • London, United Kingdom, TW7 6AF
        • Chelsea and Westminster Hospital
      • Luton, United Kingdom, LU4 0DZ
        • Luton and Dunstable University Hospital
      • Plymouth, United Kingdom, PL7 2QP
        • Beacon Medical Group
      • Portadown, United Kingdom
        • Craigavon Area Hospital
      • Preston, United Kingdom, PR2 9QB
        • Panthera - Preston
      • Rochdale, United Kingdom, OL11 4AU
        • Panthera - Manchester
      • Romford, United Kingdom
        • Queens Hospital
      • Sheffield, United Kingdom, S2 5FX
        • Panthera - Sheffield
      • West Bromwich, United Kingdom
        • Sandwell General Hospital
      • Wirral, United Kingdom, CH62 6EE
        • FutureMeds - Bridle Road Clinic
      • Worcester, United Kingdom, WR5 1DD
        • Worcestershire Royal Hospital
    • Cornwall
      • Penzance, Cornwall, United Kingdom, TR18 3DX
        • Atlantic Medical Group
      • Penzance, Cornwall, United Kingdom, TR19 7HU
        • Mounts Bay Medical
  • United States
    • Alabama
      • Alexander City, Alabama, United States, 35010
        • Advanced Cardiovascular LLC
      • Birmingham, Alabama, United States, 35209
        • Central Alabama Research
      • Birmingham, Alabama, United States, 35243
        • Cardiovascular Associates of the Southeast, LLC
      • Birmingham, Alabama, United States, 35205
        • Ascension - Cardiology Specialists of Birmingham
      • Fairhope, Alabama, United States, 36532
        • Eastern Shore Research Institute, LLC
      • Huntsville, Alabama, United States, 35801
        • The Heart Center Research
      • Mobile, Alabama, United States, 36608
        • Mobile Heart Specialists
      • Muscle Shoals, Alabama, United States, 35661
        • Syed Research Consultants
      • Sheffield, Alabama, United States, 35660
        • Syed Research Consultants
    • Arizona
      • Phoenix, Arizona, United States, 85018
        • Elite Clinical Studies
      • Sun City West, Arizona, United States, 85375
        • Clinical Research Institute of Arizona, LLC
      • Tucson, Arizona, United States, 85745
        • Eclipse Clinical Research
    • Arkansas
      • Jonesboro, Arkansas, United States, 72405
        • NEA Baptist Clinic
      • Little Rock, Arkansas, United States, 72204
        • Cardiology and Medicine Clinic
    • California
      • Anaheim, California, United States, 92805
        • Advanced Research Center
      • Beverly Hills, California, United States, 90211
        • Westside Medical Associates of Los Angeles
      • Canoga Park, California, United States, 91303
        • Hope Clinical Research LLC
      • Encinitas, California, United States, 92024
        • Titan Medical Research - Oceanside
      • Lincoln, California, United States, 95648
        • Clinical Trials Research
      • Lomita, California, United States, 90717
        • Torrance Clinical Research Institute Inc.
      • Los Angeles, California, United States, 90211
        • American Institute of Research
      • Northridge, California, United States, 91324
        • Amicis Research
      • Northridge, California, United States, 91325
        • Valley Clinical Trials, INC
      • Northridge, California, United States, 91324
        • Amicis Research Center-Northridge
      • Torrance, California, United States, 90502
        • Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
    • Connecticut
      • Norwalk, Connecticut, United States, 06905
        • Cardiology Associates of Fairfield County
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Excel Medical Clinical Trials
      • Clearwater, Florida, United States, 33756
        • Innovative Research of West Florida
      • Clearwater, Florida, United States, 33756
        • Clearwater Cardiovascular and Interventional Consultants
      • DeLand, Florida, United States, 32720
        • Avail Clinical Research
      • Fort Lauderdale, Florida, United States, 33308
        • Invesclinic
      • Hialeah, Florida, United States, 33016
        • New Generation Of Medical Research
      • Hialeah, Florida, United States, 33010
        • Qway Research
      • Jacksonville, Florida, United States, 32086
        • East Coast Institute for Research
      • Jacksonville, Florida, United States, 32204
        • East Coast Institute for Research - Jacksonville Monroe St
      • Jacksonville, Florida, United States, 32216
        • East Coast Institute for Research - Jacksonville University Blvd
      • Jacksonville, Florida, United States, 32216
        • East Coast Institute for Research - Perimeter Park Court
      • Lake City, Florida, United States, 32055
        • East Coast Institute for Research- Lake City
      • Miami, Florida, United States, 33175
        • ProLive Medical Research
      • Miami, Florida, United States, 33175
        • Ezy Medical Research
      • Miami, Florida, United States, 33125
        • Columbus Clinical Services
      • Miami, Florida, United States, 33186
        • Med Research of Florida, LLC
      • Miami, Florida, United States, 33126
        • Finlay Medical Research Corp
      • Miami, Florida, United States, 33144
        • A+ Research Inc
      • Naples, Florida, United States, 34104
        • New Generation of Medical Research - Naples
      • New Port Richey, Florida, United States, 34653
        • Advanced Research Institute Inc
      • Ocala, Florida, United States, 34471
        • Ocala Research Institute
      • Ormond Beach, Florida, United States, 32174
        • Ormond Beach Clinical Research LLC
      • Sarasota, Florida, United States, 34243
        • Headlands Research
      • Tampa, Florida, United States, 33634
        • JSV Clinical Research Study, Inc
      • Tampa, Florida, United States, 33614
        • BayCare Health System
      • Wellington, Florida, United States, 33449
        • Cardiology Partners Clinical Research Institute
      • Winter Haven, Florida, United States, 33880
        • Clinical Research of Central Florida
    • Georgia
      • Atlanta, Georgia, United States, 30318
        • Atlanta Diabetes Associates
      • Canton, Georgia, United States, 30114
        • East Coast Institute for Research - Canton
      • Cumming, Georgia, United States, 30084
        • Atlanta Heart Specialists
      • Dunwoody, Georgia, United States, 30338
        • Alta Pharmaceutical Research Center
      • Eatonton, Georgia, United States, 31024
        • Cardiology Care Clinic of Lake Oconee
      • Johns Creek, Georgia, United States, 30024
        • NSC Research
      • Roswell, Georgia, United States, 30076
        • Endocrine Research Solutions, Inc
      • Savannah, Georgia, United States, 31406
        • Javara Inc - SouthCoast Health
      • Suwanee, Georgia, United States, 30024
        • Herman Clinical Research
    • Illinois
      • Addison, Illinois, United States, 60101
        • Biofortis, Inc
      • Arlington Heights, Illinois, United States, 60005
        • Northwest Heart Clinical research
      • Chicago, Illinois, United States, 60602
        • IMA Clinical Research, PC
      • Gurnee, Illinois, United States, 60031
        • Clinical Investigation Specialists
      • Hazel Crest, Illinois, United States, 60429
        • Apex Medical Research
      • Oakbrook Terrace, Illinois, United States, 60657
        • Advocate Health and Hospitals Corporation
    • Indiana
      • Anderson, Indiana, United States, 46011
        • Community Health Network-Anderson
      • Elkhart, Indiana, United States, 46514
        • Midwest Cardiovascular Research and Education Foundation
      • Indianapolis, Indiana, United States, 46227
        • Community Health Network
      • Munster, Indiana, United States, 46321
        • Cardiovascular Research of Northwest Indiana, LLC
      • Munster, Indiana, United States, 46321
        • ASHA Clinical Research - Munster, LLC
    • Iowa
      • Council Bluffs, Iowa, United States, 51501
        • West Broadway Clinic
      • Des Moines, Iowa, United States, 50266
        • The Iowa Clinic - Cardiovascular Services
    • Kansas
      • Hutchinson, Kansas, United States, 67502
        • Hutchinson Clinic
      • Wichita, Kansas, United States, 67214
        • Kansas Nephrology Research Institute
      • Wichita, Kansas, United States, 67226
        • West Houston Area Clinical Trial Consultants
    • Kentucky
      • Lexington, Kentucky, United States, 40503
        • The Research Group of Lexington, LLC
      • Louisville, Kentucky, United States, 40213
        • Louisville Metabolic and Atherosclerosis Research Center (L-MARC)
      • Owensboro, Kentucky, United States, 42303
        • Research Integrity
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Cambridge Medical Trials
      • Covington, Louisiana, United States, 70433
        • Cardiovascular Associates Research, LLC - Covington, LA
      • Slidell, Louisiana, United States, 70458
        • Louisiana Heart Center
      • West Monroe, Louisiana, United States, 71291
        • Clinical Trials of America
      • Zachary, Louisiana, United States, 70791
        • Southern Clinical Research, LLC
    • Maine
      • Bangor, Maine, United States, 04401
        • Northeast Cardiology Associates
    • Maryland
      • Chevy Chase, Maryland, United States, 20815
        • Javara Inc - Healthy Steps
      • Hyattsville, Maryland, United States, 20782
        • MedStar Health Research Institute
      • Rockville, Maryland, United States, 32763
        • Optimal Research, LLC
    • Massachusetts
      • Haverhill, Massachusetts, United States, 01830
        • Mass General Brigham Pentucket Medical Associates - Haverhill
      • Methuen, Massachusetts, United States, 01844
        • ActivMed Practices and Research - Methuen
      • New Bedford, Massachusetts, United States, 02740
        • BTC of New Bedford
    • Michigan
      • Flint, Michigan, United States, 48504
        • Aa Mrc, Llc
      • Grand Rapids, Michigan, United States, 49564
        • Healthy Heart Cardiology
      • Mount Clemens, Michigan, United States, 48043
        • McLaren Macomb Regional Medical Center
      • Rochester Hills, Michigan, United States, 49546
        • Advanced Cardiology Associates
      • Southgate, Michigan, United States, 48195
        • Revival Research Institute
      • Troy, Michigan, United States, 48085
        • Oakland Medical Research Center
      • Troy, Michigan, United States, 48098
        • Arcturus Healthcare
      • Ypsilanti, Michigan, United States, 48197
        • Michigan Heart
    • Minnesota
      • Saint Louis Park, Minnesota, United States, 55416
        • Heart and Vascular Center at Methodist Hospital
    • Missouri
      • Saint Louis, Missouri, United States, 63136
        • St. Louis Heart and Vascular Cardiology
      • Saint Louis, Missouri, United States, 63117
        • IMA Clinical Research - St. Louis, MO
    • Montana
      • Missoula, Montana, United States, 59808
        • Montana Medical Research, Inc.
    • Nebraska
      • Lincoln, Nebraska, United States, 68510
        • Meridian Clinical Research- Lincoln, NE
    • Nevada
      • Las Vegas, Nevada, United States, 89119
        • AB Clinical Trials
      • Las Vegas, Nevada, United States, 89106
        • Sierra Clinical Research
      • Las Vegas, Nevada, United States, 89123
        • Advanced Biomedical Research of America
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807
        • Advanced Heart Care, LLC
      • Mullica Hill, New Jersey, United States, 08302
        • Inspira Medical Centers
      • Somerset, New Jersey, United States, 08873
        • Cardio Metabolic Institute
    • New Mexico
      • Albuquerque, New Mexico, United States, 87106
        • New Mexico Clinical Research & Osteoporosis Center Inc.
    • New York
      • Bronx, New York, United States, 10455
        • CHEAR Center LLC
      • New Windsor, New York, United States, 12553
        • Mid-Hudson Medical Research, PLLC - New Windsor
      • New York, New York, United States, 10036
        • IMA Clinical Research PC and Affiliates- New York, NY
      • North Massapequa, New York, United States, 11758-1802
        • DiGiovanna Institute for Medical Education And Research
      • Saratoga Springs, New York, United States, 12866
        • Saratoga Clinical Research
      • Vestal, New York, United States, 13760
        • Meridian Clinical Research- Endwell, NY
      • West Seneca, New York, United States, 14224
        • Southgate Medical Group
      • Westfield, New York, United States, 14787
        • Great Lakes Medical Research, LLC
    • North Carolina
      • Asheboro, North Carolina, United States, 27203
        • Javara Inc - Wake Forest Health Network Family Physicians - Sunset Avenue
      • Cary, North Carolina, United States, 27518
        • Cary Research Group, LLC
      • Charlotte, North Carolina, United States, 28204
        • The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute
      • Charlotte, North Carolina, United States, 28210
        • Javara Inc - Tryon Medical Partners LLC
      • Greensboro, North Carolina, United States, 27401
        • Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health
      • Greensboro, North Carolina, United States, 28210
        • Medication Management, LLC
      • Lenoir, North Carolina, United States, 28645
        • Clinical Trials of America, LLC - Lenoir, NC
      • Morehead City, North Carolina, United States, 28557
        • Diabetes and Endocrinology Consultants, P.C
      • Morganton, North Carolina, United States, 28655
        • Burke Primary Care
      • Pinehurst, North Carolina, United States, 28374
        • Pinehurst Medical Clinic, Inc.
      • Statesville, North Carolina, United States, 28625
        • Piedmont Healthcare - Statesville
      • Wilmington, North Carolina, United States, 28412
        • Wilmington Health Associates
      • Winston-Salem, North Carolina, United States, 27157
        • Wake Forest University Health Sciences
    • North Dakota
      • Fargo, North Dakota, United States, 58104
        • Lillestol Research LLC
    • Ohio
      • Cincinnati, Ohio, United States, 45219
        • Meridian Clinical Research - Cincinnati, OH
      • Cincinnati, Ohio, United States, 45246
        • Meridian Clinical Research - Springfield, OH
      • Dayton, Ohio, United States, 45419
        • PriMed Clinical Research
      • Lima, Ohio, United States, 45805
        • NexGen Research
      • Marion, Ohio, United States, 43302
        • SV Research
      • Maumee, Ohio, United States, 43537
        • Advanced Medical Research (AMR)
    • Oklahoma
      • Norman, Oklahoma, United States, 73072
        • Lynn Institute of Norman
      • Oklahoma City, Oklahoma, United States, 73111
        • Lynn Health Science Institute - East
    • Pennsylvania
      • Duncansville, Pennsylvania, United States, 16635
        • Altoona Center for Clinical Research
      • Horsham, Pennsylvania, United States, 19044
        • Abington Medical Specialists, P.C. dba AMS Cardiolog
      • Pittsburgh, Pennsylvania, United States, 15236
        • Preferred Primary Care Physicians Group - Pleasant Hills
      • Smithfield, Pennsylvania, United States, 15478
        • Frontier Clinical Research
      • Wyomissing, Pennsylvania, United States, 19610
        • Penn State Health Medical Group- Berks Cardiology
    • Rhode Island
      • Cumberland, Rhode Island, United States, 02864
        • Clinical Research Collaborative, LLC
    • South Carolina
      • Fort Mill, South Carolina, United States, 29707
        • Piedmont Research Partners, LLC
      • Orangeburg, South Carolina, United States, 29118
        • South Carolina Clinical Research LLC
      • Simpsonville, South Carolina, United States, 29681
        • Hillcrest Clinical Research
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc
    • Tennessee
      • Chattanooga, Tennessee, United States, 37404
        • Chattanooga Research & Medicine, PLLC
      • Germantown, Tennessee, United States, 38138
        • Stern Cardiovascular Foundation, Inc
      • Kingsport, Tennessee, United States, 37660
        • Holston Medical Group
      • Knoxville, Tennessee, United States, 37909
        • New Phase Research & Development
      • Powell, Tennessee, United States, 37849
        • Cardiovascular Research of Knoxville
    • Texas
      • Amarillo, Texas, United States, 79109
        • PharmaTex Research, LLC
      • Austin, Texas, United States, 78705
        • Central Texas Clinical Research
      • Austin, Texas, United States, 78745
        • Accelemed Research Institute
      • Corpus Christi, Texas, United States, 78414
        • Private Practice - O. Alejandro Brusco, MD FACE PA
      • Cypress, Texas, United States, 77433
        • Javara Inc - Bridge Creek Family Medicine
      • Dallas, Texas, United States, 75325
        • Southwest Family Medicine Associates
      • Dallas, Texas, United States, 76107
        • Texas Health Research & Education Institute
      • Edinburg, Texas, United States, 78539
        • South Texas Research Institute
      • El Paso, Texas, United States, 79905
        • David Turbay, MD, PLLC
      • Fort Worth, Texas, United States, 76164
        • Valley Institute of Research - Fort Worth
      • Fort Worth, Texas, United States, 76132
        • Javara Inc - Texas Health Care Family Physicians
      • Friendswood, Texas, United States, 77546
        • Mt. Olympus Medical Research
      • Houston, Texas, United States, 77074
        • Southwest Clinical Trials
      • Houston, Texas, United States, 77030
        • Texas Heart Institute
      • Houston, Texas, United States, 77025
        • Angiocardiac Care of Texas
      • Houston, Texas, United States, 77002
        • East Texas Cardiology, PA
      • Houston, Texas, United States, 77094
        • BioStar Clinical Research
      • Houston, Texas, United States, 77375
        • Texas Center for Drug Development
      • Katy, Texas, United States, 77493
        • West Houston Area Clinical Trial Consultants, LLC
      • Laredo, Texas, United States, 78041
        • Milton Haber, M.D
      • North Richland Hills, Texas, United States, 76180
        • North Hills Medical Research, Inc.
      • Paris, Texas, United States, 75460
        • Tapia Internal Medicine Clinic
      • Pearland, Texas, United States, 60602
        • LinQ Research, LLC
      • Plano, Texas, United States, 75093
        • Styde Research
      • San Antonio, Texas, United States, 78215
        • Sun Research Institute
      • San Antonio, Texas, United States, 78220
        • San Antonio Premier Internal Medicine
      • San Antonio, Texas, United States, 78249
        • Bandera Family HealthCare Research, LLC (BFHC)
      • Sherman, Texas, United States, 75092
        • Sherman Clinical Research
      • Stephenville, Texas, United States, 76401
        • Stephenville Medical & Surgical Clinic
      • The Woodlands, Texas, United States, 77382
        • Javara Inc - Highland Woods Health
    • Utah
      • Clinton, Utah, United States, 84015
        • Alpine Research Organization, Inc.
      • Draper, Utah, United States, 84020
        • Physicians' Research Options (PRO)
      • Salt Lake City, Utah, United States, 84102
        • Wasatch Clinical Research
    • Virginia
      • Burke, Virginia, United States, 22015
        • Burke Internal Medicine & Research
      • Manassas, Virginia, United States, 20109
        • Carient Heart & Vascular
      • Norfolk, Virginia, United States, 23510
        • York Clinical Research LLC
      • Richmond, Virginia, United States, 23219
        • Dominion Medical Associates
    • Washington
      • Tacoma, Washington, United States, 98405
        • Universal Research Group LLC
      • Tacoma, Washington, United States, 98405
        • MultiCare Institute for Research and Innovation- Tacoma
    • Wisconsin
      • Green Bay, Wisconsin, United States, 54303
        • Prevea Health
      • Kenosha, Wisconsin, United States, 53144
        • Clinical Investigation Specialists

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Males & females ≥ 18 years age.
  • Established ASCVD including:
  • Coronary artery disease
  • Cerebrovascular disease
  • Peripheral Artery disease
  • On maximally tolerated lipid-modifying therapy
  • Fasting LDL-C ≥ 55 mg/dL
  • Fasting triglycerides < 400 mg/dL
  • Estimated glomerular filtration rate ≥ 30 mL/min

Exclusion Criteria:

  • New York Heart Association class III or IV heart failure or left ventricular ejection fraction < 30%
  • Have been hospitalized for Heart Failure within 5 years prior to screening
  • Had non-fatal MI, non-fatal stroke, non-elective coronary revascularization and/or hospitalization for unstable angina or chest pain within past 3 months prior to screening
  • Uncontrolled hypertension
  • Diagnosis of homozygous familial hypercholesterolemia (HoFH)
  • Active liver disease
  • HbA1c ≥10%
  • Thyroid Stimulating Hormone (TSH) > 1.5 times upper limit normal
  • Creatine kinase > 3 times upper limit normal
  • History of malignancy with surgery in past 3 years
  • History of alcohol or drug abuse within past 5 years
  • Received treatment with investigational product or device within past 30 days excluding Coronavirus treatment or vaccine
  • Known allergy to study drug
  • Participated in previous obicetrapib trial
  • Taking gemfibrozil within 30 days screening

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: obicetrapib 10mg
one 10mg tablet, once daily.
Drug: Obicetrapib
10mg obicetrapib tablet
Placebo Comparator: Placebo
one placebo tablet, once daily
Drug: Placebo
Placebo tablet to resemble obicetrapib

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Major Adverse Cardiovascular Effect (MACE)
Time Frame: 30 months after last participant randomized
To evaluate the effect of obicetrapib on the risk of MACE
30 months after last participant randomized

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

NewAmsterdam Pharma

Collaborators

Monash University

Investigators

  • Study Director: Marc Ditmarsch, MD, NewAmsterdam Pharma

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 7, 2022

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

November 1, 2026

Study Registration Dates

First Submitted

November 22, 2021

First Submitted That Met QC Criteria

January 20, 2022

First Posted (Actual)

January 21, 2022

Study Record Updates

Last Update Posted (Estimated)

June 4, 2024

Last Update Submitted That Met QC Criteria

June 3, 2024

Last Verified

June 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TA-8995-304

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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