A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer (EMBER-4)

April 1, 2026 updated by: Eli Lilly and Company

EMBER-4: A Randomized, Open-Label, Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients Who Have Previously Received 2 to 5 Years of Adjuvant Endocrine Therapy for ER+, HER2- Early Breast Cancer With an Increased Risk of Recurrence

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.

Study Overview

Status

Active, not recruiting

Conditions

Breast Neoplasms

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

8000

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Berazategui, Argentina, B1884BBF
    - Centro de Oncología e Investigación de Buenos Aires
  - Buenos Aires, Argentina, C1426ANZ
    - Instituto Alexander Fleming
  - Buenos Aires, Argentina, C1426ABP
    - Fundación Respirar
  - Buenos Aires, Argentina, 1426
    - Centro Oncológico Korben
  - Buenos Aires, Argentina, C1128AAF
    - Mautalen Salud e Investigacion
  - Buenos Aires, Argentina, C1061
    - CIPREC
  - Buenos Aires, Argentina, 1425
    - Investigaciones Clinicas Moleculares (ICM)
  - Buenos Aires, Argentina, 1113
    - Centro de Investigaciones Medicas y Desarrollo LC
  - CABA, Argentina, C1430EGF
    - Clinica Adventista Belgrano
  - Capital, Argentina, X5008HHW
    - Centro Medico Privado CEMAIC
  - La Rioja, Argentina, F5300COE
    - Fundación CORI para la Investigación y Prevención del Cáncer
  - Mar del Plata, Argentina, B7600FZO
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Mendoza, Argentina, 5500
    - Fundacion Scherbovsky
  - Rosario, Argentina, S2000DEJ
    - Fundacion Estudios Clinicos
  - Río Cuarto, Argentina, 5800
    - Instituto Medico Rio Cuarto
  - San Juan, Argentina, 5400
    - Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
  - San Juan, Argentina, 5400
    - Instituto San Marcos
  - San Miguel de Tucumán, Argentina, 4000
    - Exelsus Oncologia Clinica
  - San Nicolás, Argentina, 2900
    - Go Centro Medico San Nicolás
  - Viedma, Argentina, R8500ACE
    - Clinica Viedma S. A
Australia
- - Ballarat Central, Australia, 3350
    - Ballarat Health Services
  - Box Hill, Australia, 3128
    - Box Hill Hospital
  - Clayton, Australia, 3168
    - Monash Health
  - Coffs Harbour, Australia, 2450
    - Coffs Harbour Health Campus
  - Darlinghurst, Australia, 2010
    - St Vincent's Hospital
  - Geelong, Australia, 3220
    - Barwon Health
  - Hobart, Australia, 7000
    - Royal Hobart Hospital
  - Launceston, Australia, 7250
    - Launceston General Hospital
  - Liverpool, Australia, 2170
    - Liverpool Hospital
  - Mackay, Australia, 4740
    - Mackay Base Hospital
  - Melbourne, Australia, 3065
    - St Vincent's Hospital
  - Melbourne, Australia, 3076
    - Northern Hospital
  - Melbourne, Australia, 3135
    - Maroondah Hospital
  - Nedlands, Australia, 6009
    - Breast Cancer Research Centre-WA
  - Newcastle, Australia, 2290
    - Lake Macquarie Private Hospital
  - Shepparton, Australia, 3630
    - Goulburn Valley Health
  - Southport, Australia, 4215
    - Gold Coast University Hospital
  - Sydney, Australia, 2060
    - Mater Hospital Sydney
  - Tiwi, Australia, 0810
    - Royal Darwin Hospital
  - Townsville, Australia, 4814
    - The Townsville Hospital
  - Urraween, Australia, 4655
    - Hervey Bay Hospital
  - Woodville, Australia, 5011
    - The Queen Elizabeth Hospital
Austria
- - Graz, Austria, 8036
    - Medizinische Universitat Graz
  - Salzburg, Austria, 5020
    - Uniklinikum Salzburg
  - Schwaz, Austria, 6130
    - Private Practice - Dr. Hubalek
  - Vienna, Austria, 1090
    - Medizinische Universitat Wien
  - Vienna, Austria, 1090
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1130
    - Klinik Hietzing
Belgium
- - Anderlecht, Belgium, 1070
    - Institut Jules Bordet
  - Auderghem, Belgium, 1160
    - CHIREC - site delta
  - Brussels, Belgium, 1200
    - Cliniques Universitaires Saint-luc
  - Brussels, Belgium, 1020
    - Centre Hospitalier Universitaire Brugmann
  - Brussels, Belgium, 1000
    - CHU Saint-Pierre
  - Charleroi, Belgium, 6000
    - Grand Hôpital de Charleroi
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis
  - Ieper, Belgium, 8900
    - Jan Yperman Ziekenhuis
  - Kortrijk, Belgium, 8500
    - AZ Groeninge Campus Kennedylaan
  - La Louvière, Belgium, 7100
    - Groupe Jolimont
  - Leuven, Belgium, 3000
    - UZ Leuven
  - Liège, Belgium, 4000
    - Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
  - Namur, Belgium, 5000
    - CHU UCL Namur/Site Sainte Elisabeth
  - Ostend, Belgium, 8400
    - AZ Oostende vzw
  - Ottignies, Belgium, 1340
    - Clinique Saint Pierre
  - Sint-Niklaas, Belgium, B-9100
    - AZ Nikolaas
  - Verviers, Belgium, 4800
    - CHR Verviers - La Tourelle
Brazil
- - Barretos, Brazil, 14784400
    - Fundacao Pio Xii - Hospital De Cancer De Barretos
  - Belo Horizonte, Brazil, 30180-060
    - Oncocentro de Minas Gerais
  - Belém, Brazil, 66063-495
    - CTO - Centro de Tratamento Oncológico
  - Brasília, Brazil, 70200-730
    - Hospital Sirio Libanes
  - Curitiba, Brazil, 80810050
    - Centro Integrado de Oncologia de Curitiba
  - Fortaleza, Brazil, 60430230
    - Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
  - Goiânia, Brazil, 74605070
    - Hospital Araujo Jorge
  - Ijuí, Brazil, 98700-000
    - ONCOSITE - Centro de Pesquisa Clinica em Oncologia
  - Londrina, Brazil, 86015-520
    - Hospital de Cancer de Londrina
  - Porto Alegre, Brazil, 90610-000
    - Hospital Sao Lucas da PUCRS
  - Porto Alegre, Brazil, 90110-270
    - Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
  - Porto Alegre, Brazil, 90035001
    - Hospital Moinhos de Vento
  - Porto Velho, Brazil, 76834-899
    - Hospital de Amor Amazônia
  - Recife, Brazil, 50070-170
    - Multihemo
  - Ribeirão Preto, Brazil, 14051-140
    - Hospital de Clínicas de Ribeirão Preto
  - Rio de Janeiro, Brazil, 22061-080
    - Hospital São Lucas de Copacabana
  - Rio de Janeiro, Brazil, 22250-905
    - Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
  - Rio de Janeiro, Brazil, 20560121
    - Instituto Nacional de Cancer - INCa
  - Rio de Janeiro, Brazil, 22793080
    - Instituto de Educação, Pesquisa e Gestão em Saúde
  - Salvador, Brazil, 40170-110
    - Nucleo de Oncologia da Bahia
  - Santo André, Brazil, 09060-650
    - Faculdade de Medicina do ABC
  - São José do Rio Preto, Brazil, 15090000
    - Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
  - São Paulo, Brazil, 01327-001
    - Hospital Alemao Oswaldo Cruz
  - São Paulo, Brazil, 04556-100
    - Hospital Santa Paula
  - São Paulo, Brazil, 01308-060
    - Hospital Sirio Libanes
  - São Paulo, Brazil, 01246-000
    - Icesp - Instituto Do Câncer Do Estado de São Paulo
  - São Paulo, Brazil, 04014-002
    - Núcleo de Pesquisa Clínica da Rede São Camilo
  - São Paulo, Brazil, 04543-000
    - Instituto D'Or de Pesquisa e Ensino (IDOR)
  - São Paulo, Brazil, 01229-010
    - NotreDame Intermedica Saude S.A
  - São Paulo, Brazil, 01509-010
    - A. C. Camargo Cancer Center
  - São Paulo, Brazil, 01317-001
    - Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA
  - São Paulo, Brazil, 01321-001
    - Hospital BP
  - São Paulo, Brazil, 01221-020
    - IPITEC
  - São Paulo, Brazil, 01236030
    - Instituto de Ensino e Pesquisa São Lucas
  - São Paulo, Brazil, 04039-901
    - Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
  - Vitória, Brazil, 29055450
    - CEDOES
Canada
- - Calgary, Canada, T2N 5G2
    - Arthur J.E. Child Comprehensive Cancer Centre
  - London, Canada, N6A 5W9
    - Victoria Hospital & Children's Hospital - London Health Sciences Centre
  - Montreal, Canada, H2X 3E4
    - Centre Hospitalier de l'Universite de Montreal
  - Montreal, Canada, H3T 1E2
    - Jewish General Hospital
  - Montreal, Canada, H4J 1C5
    - Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - H -T
  - Québec, Canada, G1S 4L8
    - CHU de Québec-Université Laval, Hôpital du Saint-Sacrement
  - Surrey, Canada, V3V 1Z2
    - BC Cancer Surrey
  - Toronto, Canada, M4N 3M5
    - Sunnybrook Research Institute
  - Toronto, Canada, M3M 0B2
    - Humber River Hospital
China
- - Anyang, China, 455000
    - Anyang Cancer Hospital
  - Baoding, China, 071000
    - Affiliated Hospital of Hebei University
  - Beijing, China, 100005
    - Beijing Hospital
  - Beijing, China, 100034
    - Peking University People's Hospital
  - Beijing, China, 100021
    - Cancer Hospital Chinese Academy of Medical Science
  - Beijing, China, 100050
    - Beijing Friendship Hospital Affiliate of Capital University
  - Changchun, China, 130021
    - The First Hospital of Jilin University
  - Changde, China, 415003
    - The First People's Hospital of Changde City
  - Changsha, China, 410008
    - Xiangya Hospital Central South University
  - Changsha, China, 421000
    - Hunan Cancer Hospital
  - Chengdu, China, 610042
    - Sichuan Cancer Hospital
  - Deyang, China, 618000
    - Deyang City People's Hospital
  - Dongguan, China, 523059
    - Dongguan People's Hospital
  - Foshan, China, 528399
    - Shunde Hospital of Southern Medical Univesity
  - Fuzhou, China, 350001
    - Fujian Medical University Union Hospital-1 Bingfanglou
  - Fuzhou, China, 350025
    - The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
  - Guangzhou, China, 510060
    - Sun Yat-sen University Cancer Center
  - Guangzhou, China, 511400
    - Guangdong Maternity and Child Health Care Hospital
  - Haikou, China, 570311
    - Hainan General Hospital
  - Hangzhou, China, 310014
    - Zhejiang Provincial People's Hospital
  - Hangzhou, China, 310022
    - Zhejiang Cancer Hospital
  - Hangzhou, China, 310000
    - The First People's Hospital of Hangzhou
  - Huai'an, China, 223300
    - First Huai'an Hospital Affiliated to Nanjing Medical University
  - Huizhou, China, 516001
    - Huizhou Municipal Central Hospital
  - Jiangmen, China, 529000
    - Jiangmen Center Hospital
  - Jinan, China, 250013
    - Jinan Central Hospital
  - Jining, China, 272100
    - Jining Medical University - Affiliated Hospital
  - Luoyang, China, 471003
    - The First Affiliated Hospital of Henan University of Science &Technology
  - Nanchang, China, 330009
    - The Third Hospital of Nanchang
  - Nanjing, China, 210029
    - Jiangsu Province Hospital
  - Neijiang, China, 641000
    - The Second People's Hospital of Neijiang
  - Ningbo, China, 315010
    - Ningbo First Hospital
  - Ningbo, China, 315010
    - Hwa Mei Hospital University of Chinese Academy of Sciences
  - Shanghai, China, 200032
    - Fudan University Shanghai Cancer Center
  - Shantou, China, 515041
    - Cancer Hospital of Shantou University Medical College
  - Shenzhen, China, 518020
    - ShenZhen People's Hospital
  - Shenzhen, China, 518035
    - Shenzhen Second People's Hospital
  - Shenzhen, China
    - Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
  - Suzhou, China, 215006
    - The First Affiliated Hospital of Soochow University
  - Tianjing, China, 300060
    - Tianjin Medical University Cancer Institute & Hospital
  - Wuhan, China, 430079
    - Hubei Cancer Hospital
  - Wuhan, China, 430022
    - Union Hospital Tongji Medical College Huazhong University of Science and Technology
  - Wuhan, China, 430060
    - Renmin Hospital of Wuhan University
  - Wuhu, China, 241001
    - Wannan Medical College Yijishan Hospital
  - Xi'an, China, 710061
    - The First Affiliated Hospital of Xi'an Jiaotong University
  - Xiangyang, China, 441021
    - Xiangyang Central Hospital
  - Yongzhou, China, 425000
    - The Central Hospital of Yongzhou - North Campus
  - Yueyang, China, 414000
    - The First People's Hospital of Yueyang
  - Yuncheng, China, 044000
    - Yuncheng Central Hospital - Eastern Hospital
  - Zhanjiang, China, 524002
    - Central Hospital of Guangdong Provincial Agricutural Reclamation
  - Ürümqi, China, 830000
    - Xinjiang Medical University Cancer Hospital - Urumqi
Czechia
- - Brno, Czechia, 656 53
    - Masarykuv onkologicky ustav
  - Hořovice, Czechia, 268 31
    - Nemocnice Horovice
  - Hradec Králové, Czechia, 500 05
    - Fakultni nemocnice Hradec Kralove
  - Ostrava, Czechia, 708 52
    - Fakultni Nemocnice Ostrava
  - Pardubice, Czechia, 53203
    - Multiscan
  - Prague, Czechia, 14059
    - Fakultni Thomayerova nemocnice
  - Prague, Czechia, 150 06
    - Fakultni nemocnice Motol
  - Prague, Czechia, 180 81
    - Fakultni nemocnice Bulovka
France
- - Avignon, France, 84918
    - Sainte Catherine Institut du Cancer Avignon Provence
  - Bayonne, France, 64109
    - Centre Hospitalier de la Cote Basque
  - Besançon, France, 25000
    - CHU Besançon
  - Bordeaux, France, 33076
    - Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
  - Brest, France, 29609
    - CHRU de Brest
  - Clermont-Ferrand, France, 63050
    - Pôle Santé République
  - Créteil, France
    - Henri Mondor Hospital
  - La Chaussée-Saint-Victor, France, 41260
    - Polyclinique de Blois
  - La Roche-sur-Yon, France, 85000
    - CHD Vendee
  - La Rochelle, France, 17019
    - Groupe Hospitalier La Rochelle-Ré-Aunis - Hôpital Saint Louis
  - La Tronche, France, 38700
    - Chu Grenoble Alpes
  - Le Mans, France, 72000
    - Clinique Victor Hugo Le Mans
  - Limoges, France, 87039
    - Clinique Francois Chenieux
  - Lyon, France, 69008
    - Hopital Prive Jean Mermoz
  - Metz, France, 57085
    - Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy
  - Mont-de-Marsan, France, 40024
    - Centre Hospitalier Intercommunal de Mont-de-Marsan et du Pays des Sources
  - Montpellier, France, 34070
    - Centre de Cancerologie du Grand Montpellier
  - Nancy, France, 54100
    - Polyclinique de Gentilly
  - Nice, France, 06189
    - Centre Antoine-Lacassagne
  - Paris, France, 75015
    - Hôpital Européen Georges Pompidou
  - Paris, France, 75970
    - Hopital Tenon
  - Paris, France, 75248
    - Institut Curie
  - Paris, France, 75014
    - Groupe hospitalier Paris saint Joseph
  - Paris, France, 75010
    - Hopital Saint-Louis
  - Paris, France, 75020
    - Groupe Hospitalier Diaconesses Croix Saint Simon
  - Pau, France, 64000
    - Centre Hospitalier de Pau
  - Perpignan, France, 66000
    - Centre Catalan d'Oncologie
  - Poitiers, France, 86021
    - Centre Hospitalier Universitaire de Poitiers
  - Reims, France, 51726
    - Institut Jean Godinot
  - Saint-Cloud, France, 92210
    - Institut Curie - site Saint-Cloud
  - Saint-Grégoire, France, 35768
    - Centre Hospitalier Privé Saint-Grégoire
  - Saint-Herblain, France, 44805
    - Institut de cancerologie de l'ouest
  - Valenciennes, France, 59300
    - Centre de cancérologie des Dentellières
  - Vandœuvre-lès-Nancy, France, 54519
    - Institut de Cancérologie de Lorraine Alexis Vautrin
Germany
- - Augsburg, Germany, 86156
    - Universitaetsklinikum Augsburg
  - Augsburg, Germany, 86150
    - Gemeinschaftspraxis hop-augsburg
  - Berlin, Germany, 13125
    - Helios Klinikum Berlin-Buch
  - Berlin, Germany, 10367
    - Praxisklinik Krebsheilkunde fur Frauen
  - Berlin, Germany, 10707
    - Onkologische Schwerpunktpraxis Kurfuerstendamm
  - Bottrop, Germany, 46236
    - Marienhospital Bottrop
  - Cologne, Germany, 50937
    - Universitaetsklinikum Koeln
  - Dessau, Germany, 06847
    - Städtisches Klinikum Dessau
  - Donauwörth, Germany, 86609
    - Onkologiezentrum Donauwörth
  - Dortmund, Germany, 44137
    - St.-Johannes-Hospital Dortmund
  - Düsseldorf, Germany, 40235
    - MVZ Medical Center Düsseldorf GmbH
  - Erlangen, Germany, 91054
    - Universitaetsklinikum Erlangen
  - Essen, Germany, 45136
    - Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
  - Frankfurt, Germany, 60431
    - Agaplesion Markus Krankenhaus
  - Freiburg im Breisgau, Germany, 79106
    - Universitaetsklinikum Freiburg
  - Friedrichshafen, Germany, 88045
    - Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer
  - Gera, Germany, 07548
    - SRH Wald-Klinikum Gera
  - Göttingen, Germany, 37073
    - OSP Göttingen
  - Herne, Germany, 44649
    - St. Anna Hospital
  - Homburg, Germany, 66421
    - Universitaetsklinikum des Saarlandes
  - Kempten, Germany, 87439
    - Klinikverbund Allgäu gGmbH
  - Kiel, Germany, 24105
    - Universitaetsklinikum Schleswig-Holstein Campus Kiel
  - Krefeld, Germany, 47805
    - Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)
  - Mannheim, Germany, 68167
    - Universitätsmedizin Mannheim
  - Mayen, Germany, 56727
    - Onkologisch-hämatologisches Forschungsinstitut am Habsburgring
  - München, Germany, 80336
    - Klinikum der Ludwig-Maximilians-Universitaet Muenchen
  - Potsdam, Germany, 14467
    - Klinikum Ernst von Bergmann
  - Schwerin, Germany, 19055
    - Helios Kliniken Schwerin
  - Stuttgart, Germany, 70376
    - Robert-Bosch-Krankenhaus
  - Suhl, Germany, 98527
    - SRH Zentralklinikum Suhl
  - Trier, Germany, 54290
    - Klinikum Mutterhaus der Borromaerinnen
  - Tübingen, Germany, 72076
    - Universitaetsklinikum Tuebingen
  - Ulm, Germany, 89075
    - Universitaetsklinikum Ulm
  - Wiesbaden, Germany, 65199
    - Helios HSK Wiesbaden
Greece
- - Athens, Greece, 115 28
    - Alexandra Hospital
  - Athens, Greece, 115 22
    - Agios Savvas Regional Cancer Hospital
  - Athens, Greece, 151 23
    - IASO Obstetrics - Gynecology Clinic
  - Athens, Greece, 151 23
    - Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T
  - Chaïdári, Greece, 12462
    - Attikon General University Hospital
  - Heraklion, Greece, 711 10
    - University General Hospital of Heraklion
  - Ioannina, Greece, 455 00
    - University Hospital of Ioannina
  - Larissa, Greece, 41110
    - University General Hospital of Larissa
  - Nea Kifissia, Greece, 145 64
    - General Oncology Hospital of Kifissia "Agioi Anargiroi"
  - Pátrai, Greece, 26504
    - University Hospital of Patras
  - Pátrai, Greece, 26443
    - Olympion General Clinic
  - Thessaloniki, Greece, 546 22
    - Bioclinic Thessaloniki
  - Thessaloniki, Greece, 570 01
    - European Interbalkan Medical Center
  - Thessaloniki, Greece, 552 36
    - Agios Loukas Clinic
Hong Kong
- - Hksar, Hong Kong
    - Queen Mary Hospital
Hungary
- - Budapest, Hungary, 1122
    - Orszagos Onkologiai Intezet
  - Budapest, Hungary, 1145
    - Uzsoki Utcai Kórház
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem Klinikai Kozpont
  - Kecskemét, Hungary, 6000
    - Bacs-kiskun Megyei Korhaz
  - Nyíregyháza, Hungary, 4400
    - Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz
India
- - Ahmedabad, India, 380054
    - Hemato Oncology Clinic
  - Ahmedabad, India, 382421
    - KD Hospital
  - Bangalore, India, 560092
    - Medstar Speciality Hospital
  - Belagavi, India, 590010
    - KLES Dr. Prabhakar Kore Hospital & M.R.C
  - Bhubaneswar, India, 751019
    - All India Institute of Medical Sciences
  - Chandigarh, India, 160012
    - Postgraduate Institute of Medical Education & Research
  - Chennai, India, 600036
    - Cancer Institute (WIA)
  - Hyderabad, India, 500082
    - Nizam's Institute of Medical Sciences
  - Kanpur, India, 208005
    - Regency Hospital
  - Karad, India, 415539
    - Krishna Institute of Medical Sciences - Karad
  - Kolhāpur, India, 416234
    - Kolhapur Cancer Centre Private Limited
  - Mumbai, India, 400012
    - Tata Memorial Hospital
  - Nagpur, India, 440027
    - Rashtrasant Tukdoji Regional Cancer Hospital
  - New Delhi, India, 110095
    - Delhi State Cancer Institute
  - Pune, India, 411057
    - Lifepoint Multispeciality Hospital
  - Pune, India, 411001
    - Grant Medical Foundation - Ruby Hall Clinic
  - Thiruvananthapuram, India, 695011
    - Regional Cancer Centre - Thiruvananthapuram
  - Visakhapatnam, India, 530017
    - Mahatma Gandhi Cancer Hospital and Research Institute
Ireland
- - Cork, Ireland, T12 DV56
    - Bon Secours Cork Hospital
  - Cork, Ireland, T12 E8YV
    - Cork University Hospital
  - Dublin, Ireland, D9
    - Beaumont Hospital, Dublin
  - Dublin, Ireland, D04 N2E0
    - St. Vincent'S University Hospital
  - Dublin, Ireland, D08 E9P6
    - St. James's Hospital
  - Dublin, Ireland, D18 AK68
    - UCD School of Medicine Beacon Hospital
  - Galway, Ireland, H91 YR71
    - Galway University Hospital
  - Sligo, Ireland, F91 H684
    - Sligo General Hospital
  - Waterford, Ireland, X91 ER8E
    - Waterford Regional Hospital
Israel
- - Haifa, Israel, 3436212
    - Carmel Hospital
  - Jerusalem, Israel, 9112001
    - Hadassah Medical Center
  - Jerusalem, Israel, 9013102
    - Shaare Zedek Medical Center
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Petah Tikva, Israel, 4941492
    - Rabin Medical Center
  - Ramat Gan, Israel, 5265601
    - Sheba Medical Center
  - Tel Aviv, Israel, 6423906
    - Sourasky Medical Center
  - Ẕerifin, Israel, 70300
    - Yitzhak Shamir Medical Center
Italy
- - Ancona, Italy, 60126
    - Aou Ospedali Riuniti Umberto I
  - Bergamo, Italy, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
  - Bologna, Italy, 40138
    - IRCCS - AOU di Bologna
  - Brindisi, Italy, 72100
    - Ospedale Antonio Perrino
  - Candiolo, Italy, 10060
    - Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
  - Florence, Italy, 50134
    - Azienda Ospedaliera Universitaria Careggi
  - Genova, Italy, 16132
    - Ospedale San Martino
  - Macerata, Italy, 62100
    - Ospedale Generale Provinciale Macerata
  - Milan, Italy, 20141
    - Istituto Europeo di Oncologia IRCCS
  - Misterbianco, Italy, 95045
    - Humanitas Istituto Clinico Catanese
  - Modena, Italy, 41125
    - Azienda Ospedaliero Universitaria
  - Monza, Italy, 20900
    - Ospedale San Gerardo-ASST Monza
  - Naples, Italy, 80100
    - University of Naples Federico II
  - Naples, Italy, 80131
    - Istituto Nazionale Tumori IRCCS Fondazione Pascale
  - Padova, Italy, 35128
    - Istituto Oncologico Veneto IRCCS
  - Parma, Italy, 43126
    - Azienda Ospedaliero Universitaria di Parma
  - Rome, Italy, 00144
    - Istituto Nazionale Tumori Regina Elena
  - Rozzano, Italy, 20089
    - Humanitas
  - Statte, Italy, 74100
    - Ospedale San Giovanni Moscati
  - Terni, Italy, 05100
    - Azienda Ospedaliera Santa Maria Terni
Japan
- - Bunkyō City, Japan, 113-8431
    - Juntendo University Hospital
  - Chiba, Japan, 260-8717
    - Chiba Cancer Center
  - Chiba, Japan, 260-8677
    - Chiba University Hospital
  - Chūōku, Japan, 104-8560
    - St. Luke's International Hospital
  - Fukuoka, Japan, 811-1395
    - National Hospital Organization Kyushu Cancer Center
  - Fukushima, Japan, 960-1295
    - Fukushima Medical University
  - Fukuyama, Japan, 721-8511
    - Fukuyama City Hospital
  - Gifu, Japan, 501-1194
    - Gifu University Hospital
  - Hachioji-shi, Japan, 192-0032
    - Tokai University Hachioji Hospital
  - Hirakata, Japan, 573-1191
    - Kansai Medical University Hospital
  - Hiroshima, Japan, 734-8551
    - Hiroshima University Hospital
  - Hiroshima, Japan, 730-8518
    - Hiroshima City Hospital
  - Izumo, Japan, 693-0021
    - Shimane University Hospital
  - Kagoshima, Japan, 892-0833
    - Sagara Hospital
  - Kamogawa, Japan, 296-0041
    - Kameda Clinic
  - Kanazawa, Japan, 920-8530
    - Ishikawa Prefectural Central Hospital
  - Kawasaki, Japan, 216-8511
    - St. Marianna University Hospital
  - Kumamoto, Japan, 862-8655
    - Kumamoto Shinto General Hospital
  - Kumamoto, Japan, 860-0812
    - Kumamoto Breast Surgical Hospital
  - Kyoto, Japan, 606-8507
    - Kyoto University Hospital
  - Kyoto, Japan, 602-8566
    - University Hospital,Kyoto Prefectural University of Medicine
  - Kōtō City, Japan, 135-8550
    - Japanese Foundation for Cancer Research
  - Matsumoto, Japan, 390-8621
    - Shinshu University Hospital
  - Matsuyama, Japan, 791-0280
    - National Hospital Organization Shikoku Cancer Center
  - Miyazaki, Japan, 880-8510
    - Miyazaki Prefectural Miyazaki Hospital
  - Mukai-awagasaki, Japan, 920-0265
    - Kanazawa Medical University Hospital
  - Nagoya, Japan, 466-8560
    - Nagoya University Hospital
  - Nagoya, Japan, 467-8602
    - Nagoya City University Hospital
  - Naha, Japan, 901-0154
    - Naha Nishi Clinic
  - Niigata, Japan, 951-8566
    - Niigata Cancer Center Hospital
  - Nishinomiya, Japan, 663-8501
    - Hyogo Medical University Hospital
  - Okayama, Japan, 700-8558
    - Okayama University Hospital
  - Okinawa, Japan, 904-2195
    - Nakagami Hospital Okinawa
  - Osaka, Japan, 540-0006
    - National Hospital Organization - Osaka National Hospital - Institute For Clinical Research
  - Otashi, Japan, 373-8550
    - Gunma Prefectural Cancer Center
  - Sagamihara, Japan, 252-0375
    - Kitasato University Hospital
  - Saitama, Japan, 330-8553
    - Saitama Red Cross Hospital
  - Sapporo, Japan, 060-8648
    - Hokkaido University Hospital
  - Sapporo, Japan, 003-0804
    - National Hospital Organization Hokkaido Cancer Center
  - Sendai, Japan, 980-8574
    - Tohoku University Hospital
  - Shinagawa City, Japan, 142-8555
    - Showa Medical University Hospital
  - Shinjyuku-ku, Japan, 162-8655
    - National Center for Global Health and Medicine
  - Shizuoka, Japan, 420-8527
    - Shizuoka General Hospital
  - Takasaki, Japan, 370-0829
    - National Hospital Organization Takasaki General Medical Center
  - Tokushima, Japan, 770-8503
    - Tokushima University Hospital
  - Tsukuba, Japan, 305-8576
    - Tsukuba University Hospital
  - Utsunomiya, Japan, 320-0834
    - Tochigi Cancer Center
  - Yahaba-cho, Shiwa-gun, Japan, 028-3695
    - Iwate Medical University Hospital
  - Yokohama, Japan, 232-0024
    - Yokohama City University Medical Center
  - Yokohama, Japan, 2418515
    - Kanagawa Cancer Center
Mexico
- - Chihuahua City, Mexico, 31207
    - Scientia Investigacion Clinica S.C.
  - Ciudad Madero, Mexico, 89440
    - Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
  - Guadalajara, Mexico, 44650
    - Clinica de Investigacion en Reumatologia y Obesidad S. C.
  - Guadalajara, Mexico, 44630
    - CIO - Centro de Inmuno-Oncología de Occidente
  - León, Mexico, 37178
    - Preparaciones Oncologicas
  - Mexico City, Mexico, 03310
    - Grupo Medico Camino Sc
  - Mexico City, Mexico, 03100
    - CENEIT Oncológicos. Centro Especializado en Investigación y Tratamientos Oncológicos
  - Monterrey, Mexico, 64040
    - Axis Heilsa S. de R.L. de C.V.
  - Monterrey, Mexico, 64060
    - Centro Regiomontano de Investigacion
  - Monterrey, Mexico, 64460
    - Filios Alta Medicina
  - Oaxaca City, Mexico, 68020
    - Centro de Investigacion Clinica de Oaxaca
  - Oaxaca City, Mexico, 68000
    - Oaxaca Site Management Organization
  - Puebla City, Mexico, 72424
    - Unidad Médica Onco-hematológica
  - Querétaro, Mexico, 76100
    - PanAmerican Clinical Research - Querétaro - Avenida Antea
  - San Luis Potosí City, Mexico, 78209
    - Oncologico Potosino, S.C.
  - San Pedro Garza García, Mexico, 66278
    - Centro Medico Zambrano Hellion
  - Tijuana, Mexico, 22010
    - Hospital Angeles
  - Toluca, Mexico, 50180
    - Centro Oncologico Estatal ISSEMyM ( COEI )
Netherlands
- - Assen, Netherlands, 9401 RK
    - Wilhelmina Ziekenhuis Assen
  - Breda, Netherlands, 4818 CK
    - Amphia Ziekenhuis, locatie Breda Molengracht
  - Delft, Netherlands, 2625 AD
    - Reinier de Graaf Ziekenhuis, locatie Delft
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Albert Schweitzer Ziekenhuis, locatie Dordwijk
  - Hengelo, Netherlands, 7555 DL Hengelo
    - Ziekenhuisgroep Twente, locatie Almelo
  - Hoofddorp, Netherlands, 2134 TM
    - Spaarne Gasthuis - Hoofddorp
  - Maastricht, Netherlands, 6229 HX
    - Maastricht UMC+
  - The Hague, Netherlands, 2545 AA
    - Haga Ziekenhuis locatie Leyweg
  - Venlo, Netherlands, 5912 BL
    - VieCuri Medisch Centrum, locatie Venlo
  - Zaandam, Netherlands, 1502 DV
    - Zaans Medisch Centrum
Poland
- - Gdynia, Poland, 81-519
    - Szpitale Pomorskie Sp. z o. o.
  - Koszalin, Poland, 75-581
    - Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie
  - Lodz, Poland, 91-211
    - Salve Medica
  - Opole, Poland, 45-061
    - Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego
  - Oświęcim, Poland, 32-600
    - FORMED2
  - Siedlce, Poland, 08-110
    - Mazowiecki Szpital Wojewódzki w Siedlcach
  - Torun, Poland, 87-100
    - MICS Centrum Medyczne Torun
  - Warsaw, Poland, 01-748
    - Luxmed Onkologia sp. z o. o.
  - Warsaw, Poland, 02-781
    - Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Portugal
- - Almada, Portugal, 2805-267
    - Hopital Garcia de Orta
  - Lisbon, Portugal, 1400-038
    - Champalimaud Foundation
  - Lisbon, Portugal, 1500-650
    - Hospital da Luz Lisboa
  - Lisbon, Portugal, 1649-035
    - Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria
  - Lisbon, Portugal, 2674-514
    - Hospital Beatriz Ângelo
  - Vila Nova de Gaia, Portugal, 4434-502
    - Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I
Romania
- - Brasov, Romania, 500283
    - C.M.D.T.A. Neomed
  - Bucharest, Romania, 030171
    - Spitalul Clinic Coltea
  - Bucharest, Romania, 013812
    - SC Memorial Healthcare International SRL
  - Bucharest, Romania, 010644
    - Onco Medint Srl
  - Bucharest, Romania, 012292
    - Lotus-Med
  - Bucharest, Romania, 031422
    - Gral Medical Diagnostic Center
  - Cluj-Napoca, Romania, 400015
    - Institutul Oncologic Cluj
  - Craiova, Romania, 200542
    - Centrul de Oncologie "Sfântul Nectarie"
  - Otopeni, Romania, 075100
    - Radiology Therapeutic Center
  - Ovidiu, Romania, 905900
    - Ovidius Clinical Hospital OCH
  - Timișoara, Romania, 300166
    - S C Oncocenter Oncologie Clinica S R L
Singapore
- - Singapore, Singapore, 188770
    - Raffles Hospital
  - Singapore, Singapore, 168583
    - National Cancer Centre Singapore
Slovakia
- - Bratislava, Slovakia, 833 10
    - Narodny onkologicky ustav
  - Bratislava, Slovakia, 812 50
    - Onkologicky Ustav sv. Alzbety
South Korea
- - Busan, South Korea, 46033
    - Dongnam Institute of Radiological and Medical Sciences
  - Cheonan-si, South Korea, 31151
    - Soon Chun Hyang University Cheonan Hospital
  - Cheongju-si, South Korea, 28644
    - Chungbuk National University Hospital
  - Daegu, South Korea, 41404
    - Kyungpook National University Chilgok Hospital
  - Goyang-si, South Korea, 10408
    - National Cancer Center
  - Gyeongsan-si, South Korea, 42415
    - Yeungnam Univeristy Medical Center
  - Hwasun-gun, South Korea, 58128
    - Chonnam National University Hwasun Hospital
  - Incheon, South Korea, 22332
    - Inha University Hospital
  - Namdong-gu, South Korea, 21565
    - Gachon University Gil Medical Center
  - Seongnam, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Seongnam-si, South Korea, 13496
    - CHA Bundang Medical Center, CHA University
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05505
    - Asan Medical Center
  - Seoul, South Korea, 06351
    - Samsung Medical Center
  - Seoul, South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 06591
    - The Catholic Univ. of Korea Seoul St. Mary's Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 06273
    - Gangnam Severance Hospital
  - Seoul, South Korea, 08308
    - Korea University Guro Hospital
  - Suwon, South Korea, 16499
    - Ajou University Hospital
  - Ulsan, South Korea, 44033
    - Ulsan University Hospital
Spain
- - A Coruña, Spain, 15006
    - CHUAC-Hospital Teresa Herrera
  - Alicante, Spain, 03010
    - Hospital General Universitario de Alicante
  - Almería, Spain, 04009
    - Hospital Universitario Torrecárdenas
  - Badajoz, Spain, 06006
    - Hospital Infanta Cristina
  - Barcelona, Spain, 08036
    - Hospital Clinic de Barcelona
  - Barcelona, Spain, 08028
    - Hospital Universitari Dexeus
  - Barcelona, Spain, 08035
    - Hospital Universitari Vall d'Hebron
  - Barcelona, Spain, 08041
    - Hospital de la Santa Creu i Sant Pau
  - Barcelona, Spain, 08023
    - Hospital Quiron Barcelona
  - Barcelona, Spain, 08003
    - Parc de Salut Mar - Hospital del Mar
  - Bilbao, Spain, 48013
    - Osi Bilbao-Basurto
  - Burgos, Spain, 09006
    - Hospital Universitario de Burgos
  - Cáceres, Spain, 10003
    - Hospital San Pedro De Alcantara
  - El Palmar, Murcia, Spain, 30120
    - Hospital Clinico Universitario Virgen de la Arrixaca
  - Getafe, Spain, 28905
    - Hospital Universitario Getafe
  - Granada, Spain, 18016
    - Hospital Universitario San Cecilio
  - Jaén, Spain, 23007
    - Complejo Hospitalario de Jaén
  - Lleida, Spain, 25198
    - Hospital Universitario Arnau de Vilanova de Lleida
  - Logroño, Spain, 26006
    - Hospital San Pedro
  - Lugo, Spain, 27003
    - Hospital Lucus Augusti
  - Madrid, Spain, 28034
    - Hospital Universitario Ramon y Cajal
  - Madrid, Spain, 28040
    - Hospital Clinico San Carlos
  - Madrid, Spain, 28041
    - Hospital Universitario 12 de Octubre
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Madrid, Spain, 28006
    - Hospital La Princesa
  - Madrid, Spain, 28034
    - Hospital Ruber Internacional
  - Madrid, Spain, 28031
    - Hospital Universitario Infanta Leonor
  - Madrid, Spain, 28009
    - Hospital General Universitario Gregorio Marañon
  - Madrid, Spain, 28007
    - Hospital Beata Maria Ana
  - Málaga, Spain, 29016
    - Hospital Vithas Malaga
  - Málaga, Spain, 29011
    - H.R.U Málaga - Hospital Materno-infantil
  - Palma, Spain, 07120
    - Hospital Universitari Son Espases
  - Pamplona, Spain, 31009
    - Complejo Hospitalario de Navarra
  - Reus, Spain, 43204
    - Hospital Universitari Sant Joan de Reus
  - San Cristóbal de La Laguna, Spain, 38320
    - Hospital Universitario de Canarias
  - Sant Cugat del Vallès, Spain, 08915
    - Hospital Universitari General de Catalunya
  - Santa Cruz de Tenerife, Spain, 38010
    - Hospital Universitario Nuestra Señora de Candelaria
  - Seville, Spain, 41013
    - Hospital Universitario Virgen del Rocio
  - Seville, Spain, 41009
    - Hospital Universitario Virgen Macarena
  - Toledo, Spain, 45007
    - Hospital Universitario de Toledo
  - Valencia, Spain, 46010
    - Hospital Clinico de Valencia
  - Valencia, Spain, 46010
    - Hospital Quironsalud Valencia
  - Valladolid, Spain, 47003
    - Hospital Clinico Universitario de Valladolid
  - Zaragoza, Spain, 50009
    - Hospital Clínico Universitario Lozano Blesa
Taiwan
- - Changhua County, Taiwan, 50006
    - Changhua Christian Hospital
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - New Taipei City, Taiwan, 231
    - Taipei Tzu Chi General Hospital
  - Taichung, Taiwan, 407219
    - Taichung Veterans General Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Tainan, Taiwan, 73657
    - Chi Mei Hospital - Liouying Branch
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 10449
    - Mackay Memorial Hospital
  - Taipei, Taiwan, 112
    - Koo Foundation Sun Yat-Sen Cancer Center
  - Taoyuan District, Taiwan, 333
    - Chang Gung Medical Foundation-Linkou Branch
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01140
    - Adana Medical Park Seyhan Hastanesi
  - Adana, Turkey (Türkiye), 01370
    - Adana City Hospital
  - Adapazarı, Turkey (Türkiye), 54290
    - Sakarya Training and Research Hospital
  - Altindağ, Turkey (Türkiye), 06230
    - Hacettepe Universitesi
  - Ankara, Turkey (Türkiye), 06520
    - Memorial Ankara Hastanesi
  - Ankara, Turkey (Türkiye), 06800
    - Ankara Bilkent Sehir Hastanesi
  - Ankara, Turkey (Türkiye), 06170
    - Ankara Etlik City Hospital
  - Ankara, Turkey (Türkiye), 06010
    - Ankara Gülhane Eitim ve Aratrma Hastanesi
  - Antalya, Turkey (Türkiye), 07100
    - Antalya Egitim ve Arastırma Hastanesi
  - Antalya, Turkey (Türkiye), 07059
    - Akdeniz Universitesi Hastanesi
  - Bursa, Turkey (Türkiye), 16059
    - Uludag Universitesi
  - Diyarbakır, Turkey (Türkiye), 21200
    - Dicle Üniversitesi
  - Edirne, Turkey (Türkiye), 22030
    - Trakya University Medical Faculty Hospital
  - Gaziantep, Turkey (Türkiye), 27310
    - Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
  - Istanbul, Turkey (Türkiye), 34722
    - TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
  - Istanbul, Pendik, Turkey (Türkiye), 34899
    - Marmara Universitesi Pendik Egitim Arastirma Hastanesi
  - Izmir, Turkey (Türkiye), 35100
    - Ege Universitesi Hastanesi
  - Izmir, Turkey (Türkiye), 35360
    - zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
  - Izmir, Karsiyaka, Turkey (Türkiye), 009035575
    - Izmir Medical Park Hospital
  - Kocaeli, Turkey (Türkiye), 41380
    - Kocaeli Üniversitesi
  - Malatya, Turkey (Türkiye), 44280
    - İnönü Üniversitesi Turgut Özal Tıp Merkezi Eğitim ve Araştırma Hastanesi
  - Mersin, Turkey (Türkiye), 33110
    - Mersin University
  - Muğla, Turkey (Türkiye), 48000
    - Mugla Sitki Kocman Universitesi Egitim ve Arastirma Hastanesi
  - Samsun, Turkey (Türkiye), 55270
    - Ondokuz Mayıs Universitesi
  - Stanbul, Turkey (Türkiye), 34214
    - Medipol Mega Universite Hastanesi
United Kingdom
- - Colchester, United Kingdom, CO4 5JL
    - Colchester General Hospital
  - East Kilbride, Glasgow, United Kingdom, G75 8RG
    - Hairmyres Hospital
  - Edinburgh, United Kingdom, EH4 2XU
    - Western General Hospital
  - Liverpool, United Kingdom, L7 8YA
    - Clatterbridge Cancer Centre - Liverpool
  - London, United Kingdom, EC1A 7BE
    - St Bartholomew's Hospital
  - Manchester, United Kingdom, M20 4BX
    - The Christie Nhs Foundation Trust
  - Northwood, United Kingdom, HA6 2RN
    - Mount Vernon Hospital
  - Plymouth, United Kingdom, PL6 8DH
    - Derriford Hospital
  - Preston, United Kingdom, PR2 9QB
    - Panthera Biopartners - Preston
  - Reading, United Kingdom, RG1 5AN
    - Royal Berkshire Hospital
  - Rochdale, United Kingdom, OL11 4AU
    - Panthera Biopartners - Manchester
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Wigan, United Kingdom, WN1 2NN
    - Oncology Research
United States
- Alabama
  - Daphne, Alabama, United States, 36526
    - USO - Southern Cancer Center
  - Huntsville, Alabama, United States, 35805
    - Clearview Cancer Institute
  - Mobile, Alabama, United States, 36607
    - Infirmary Cancer Care
- Arizona
  - Gilbert, Arizona, United States, 85234
    - Banner MD Anderson Cancer Center
  - Glendale, Arizona, United States, 85308
    - USO - Arizona Oncology Associates - HAL
  - Phoenix, Arizona, United States, 85004
    - St. Joseph's Hospital and Medical Center
  - Phoenix, Arizona, United States, 85054
    - Mayo Clinic in Arizona - Phoenix
  - Tucson, Arizona, United States, 85719
    - The University of Arizona Cancer Center - North Campus
  - Tucson, Arizona, United States, 85711
    - TMC HealthCare
- Arkansas
  - Springdale, Arkansas, United States, 72762
    - Highlands Oncology Group
- California
  - Berkeley, California, United States, 94702
    - UCSF - John Muir Health Cancer Center Berkeley
  - Fremont, California, United States, 94538
    - Washington Health
  - Irvine, California, United States, 92612
    - Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine
  - Loma Linda, California, United States, 92350-1700
    - Loma Linda University Cancer Center
  - Monterey, California, United States, 93940
    - Pacific Cancer Care
  - Orange, California, United States, 92868
    - St. Joseph Hospital
  - Orange, California, United States, 92868
    - University of California, Irvine (UCI) Health - UC Irvine Medical Center
  - Sacramento, California, United States, 95817
    - University of California Davis (UC Davis) Comprehensive Cancer Center
  - San Diego, California, United States, 92108
    - Kaiser Permanente San Diego Mission Road
  - San Francisco, California, United States, 94158
    - UCSF Medical Center at Mission Bay
  - San Francisco, California, United States, 94110
    - Zuckerberg San Francisco General Hospital and Trauma Center
  - Stockton, California, United States, 95204
    - Saint Joseph's Medical Center
- Colorado
  - Aurora, Colorado, United States, 80045
    - Anschutz Cancer Pavilion
  - Colorado Springs, Colorado, United States, 80909
    - UCHealth Memorial Hospital
  - Fort Collins, Colorado, United States, 80528
    - UCHealth Harmony
  - Greeley, Colorado, United States, 80631
    - Banner MD Anderson Cancer Center at North Colorado Medical Center
  - Lakewood, Colorado, United States, 80228
    - USO - Rocky Mountain Cancer Centers
  - Loveland, Colorado, United States, 80538
    - Banner MD Anderson Cancer Center at McKee Medical Center
- Connecticut
  - New Haven, Connecticut, United States, 06510
    - Yale-New Haven Hospital
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20007
    - Georgetown University Medical Center
  - Washington D.C., District of Columbia, United States, 20010
    - Medstar Washington Hospital Center
- Florida
  - Altamonte Springs, Florida, United States, 32701
    - AdventHealth Altamonte Springs
  - Hollywood, Florida, United States, 33021
    - Memorial Regional Hospital
  - Hollywood, Florida, United States, 33024
    - Millennium Oncology Research Clinic
  - Jacksonville, Florida, United States, 32224
    - Mayo Clinic in Florida
  - Miami, Florida, United States, 33176
    - Miami Cancer Institute at Baptist Health, Inc.
  - Palm Bay, Florida, United States, 32901
    - USO - Cancer Care Centers of Brevard
  - Pensacola, Florida, United States, 32503
    - USO - Woodlands Medical Specialists
  - Plantation, Florida, United States, 33324
    - Miami Cancer Institute - Plantation
  - Tampa, Florida, United States, 33606
    - Tampa General Hospital
- Georgia
  - Atlanta, Georgia, United States, 30322
    - Winship Cancer Institute, Emory University
  - Atlanta, Georgia, United States, 30342
    - Northside Hospital
  - Savannah, Georgia, United States, 31405
    - Summit Cancer Care, PC
- Hawaii
  - Honolulu, Hawaii, United States, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, United States, 96819
    - Kaiser Permanente Moanalua Medical Center
- Illinois
  - Chicago, Illinois, United States, 60612
    - University of Illinois at Chicago
  - Chicago, Illinois, United States, 60611
    - Northwestern Memorial Hospital
  - Peoria, Illinois, United States, 61615
    - Illinois Cancer Care
  - Springfield, Illinois, United States, 62702
    - Simmons Cancer Institute at SIU
- Kansas
  - Westwood, Kansas, United States, 66205
    - The University of Kansas Cancer Center - Westwood
- Louisiana
  - Covington, Louisiana, United States, 70433
    - Ochsner Clinic Foundation
  - Hammond, Louisiana, United States, 70403
    - Pontchartrain Cancer Center
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Clinic Foundation
- Maine
  - York Village, Maine, United States, 03909
    - York Hospital
- Maryland
  - Bethesda, Maryland, United States, 20889
    - Walter Reed National Military Medical Center
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, United States, 02114
    - Massachusetts General Hospital
  - Danvers, Massachusetts, United States, 01923
    - Mass General/North Shore Cancer Center
  - Fairhaven, Massachusetts, United States, 02719
    - Southcoast Centers for Cancer Care
  - Foxborough, Massachusetts, United States, 02035
    - Dana-Farber Cancer Institute - Foxborough
  - Methuen, Massachusetts, United States, 01844
    - Dana-Farber Cancer Institute - Merrimack Valley
  - Milford, Massachusetts, United States, 01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
  - Newton, Massachusetts, United States, 02462
    - Mass General Cancer Center at Newton-Wellesley
  - South Weymouth, Massachusetts, United States, 02190
    - Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital
  - Worcester, Massachusetts, United States, 01655
    - University of Massachusetts Medical School
- Minnesota
  - Edina, Minnesota, United States, 55435
    - M Health Fairview Cancer Clinic -Edina
  - Minneapolis, Minnesota, United States, 55407
    - Allina Health Cancer institute
  - Minneapolis, Minnesota, United States, 55404
    - USO - Minnesota Oncology Hematology
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic in Rochester, Minnesota
- Missouri
  - Columbia, Missouri, United States, 65212
    - University of Missouri Hospital
  - St Louis, Missouri, United States, 63108
    - Washington University School of Medicine
- Nebraska
  - Omaha, Nebraska, United States, 68114
    - Nebraska Methodist Hospital
- New Hampshire
  - Lebanon, New Hampshire, United States, 03756
    - Dartmouth-Hitchcock Medical Center
  - Londonderry, New Hampshire, United States, 03053
    - Dana-Farber - New Hampshire Oncology/Hematology
- New Jersey
  - Camden, New Jersey, United States, 08103
    - MD Anderson Cancer Center at Cooper
  - East Brunswick, New Jersey, United States, 08816
    - Astera Cancer Care
  - Little Silver, New Jersey, United States, 07739
    - Regional Cancer Care Associates
  - New Brunswick, New Jersey, United States, 08901
    - Rutgers Cancer Institute of New Jersey
  - Pennington, New Jersey, United States, 08534
    - Capital Health Medical Center - Hopewell
- New Mexico
  - Albuquerque, New Mexico, United States, 87131
    - University of New Mexico Comprehensive Cancer Center
  - Albuquerque, New Mexico, United States, 87109
    - New Mexico Oncology Hematology Consultants Ltd.
- New York
  - Albany, New York, United States, 12206
    - New York Oncology Hematology Associate
  - Brooklyn, New York, United States, 11220
    - Maimonides Cancer Center
  - Brooklyn, New York, United States, 11220
    - NYU Langone Health - Brooklyn
  - Lake Success, New York, United States, 11042
    - R.J. Zuckerberg Cancer Center
  - Mineola, New York, United States, 11501
    - Perlmutter Cancer Center at NYU Langone Hospital - Long Island
  - Mount Kisco, New York, United States, 10549
    - Northern Westchester Hospital
  - New York, New York, United States, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, United States, 10016
    - Laura and Isaac Perlmutter Cancer Center
  - New York, New York, United States, 10016
    - NYC Health + Hospitals / Bellevue
  - Queens, New York, United States, 11374
    - Queens Medical Associates
  - Rochester, New York, United States, 14642
    - University of Rochester - Wilmot Cancer Institute
  - Sleepy Hollow, New York, United States, 10591
    - Phelps Hospital
  - Staten Island, New York, United States, 10305
    - Staten Island University Hospital
  - Westbury, New York, United States, 11590
    - Clinical Research Alliance
- North Carolina
  - Asheville, North Carolina, United States, 28806
    - Messino Cancer Center
- Ohio
  - Canton, Ohio, United States, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, United States, 45242
    - USO - Oncology Hematology Care
  - Toledo, Ohio, United States, 43608
    - Mercy Health - St. Vincent Medical Center
- Oregon
  - Corvallis, Oregon, United States, 97330
    - Good Samaritan Regional Medical Center
  - Eugene, Oregon, United States, 97401
    - USO - Oncology Associates of Oregon
  - Portland, Oregon, United States, 97239
    - Oregon Health and Science University
  - Tigard, Oregon, United States, 97223
    - USO - Compass Oncology
- Pennsylvania
  - Bethlehem, Pennsylvania, United States, 18015
    - St. Luke's University Health network
  - Horsham, Pennsylvania, United States, 19044
    - USO - Alliance Cancer Specialists, PC
  - Philadelphia, Pennsylvania, United States, 19107
    - Thomas Jefferson University - Clinical Research Institute
- Rhode Island
  - Providence, Rhode Island, United States, 02906
    - Lifespan Cancer Institute
- South Carolina
  - Greenville, South Carolina, United States, 29607
    - St Francis Cancer Center
- Tennessee
  - Germantown, Tennessee, United States, 38138
    - The West Clinic, PLLC dba West Cancer Center
  - Knoxville, Tennessee, United States, 37920
    - University of Tennessee Medical Center
  - Nashville, Tennessee, United States, 37203
    - Sarah Cannon Research Institute
- Texas
  - Austin, Texas, United States, 78731
    - USO - Texas Oncology
  - Dallas, Texas, United States, 75246
    - USO - Texas Oncology
  - Dallas, Texas, United States, 75231
    - USO - Texas Oncology
  - Denison, Texas, United States, 75020
    - USO - Texas Oncology
  - El Paso, Texas, United States, 79902
    - Texas Oncology - West Texas
  - El Paso, Texas, United States, 79918
    - William Beaumont Army Medical Center
  - Flower Mound, Texas, United States, 75028
    - USO - Texas Oncology
  - Fort Sam Houston, Texas, United States, 78234
    - Brooke Army Medical Center
  - Fort Worth, Texas, United States, 76104
    - The Center for Cancer and Blood Disorders
  - Fort Worth, Texas, United States, 76104
    - John Peter Smith Hospital
  - Fort Worth, Texas, United States, 76104
    - USO - Texas Oncology
  - Fredericksburg, Texas, United States, 78624
    - USO - Texas Oncology
  - McAllen, Texas, United States, 78503
    - USO - Texas Oncology
  - Plano, Texas, United States, 75075
    - USO - Texas Oncology
  - Round Rock, Texas, United States, 78665
    - Scott & White Hospital - Round Rock
  - San Antonio, Texas, United States, 78229
    - Mays Cancer Center
  - Temple, Texas, United States, 76508
    - Baylor Scott & White Medical Center - Temple
  - The Woodlands, Texas, United States, 77380
    - US Oncology Research Network
  - Webster, Texas, United States, 77598
    - USO - Texas Oncology
- Virginia
  - Charlottesville, Virginia, United States, 22908
    - University of Virginia Health System
  - Fairfax, Virginia, United States, 22031
    - Inova Schar Cancer Institute
  - Fort Belvoir, Virginia, United States, 22060
    - Fort Belvoir Community Hospital
  - Midlothian, Virginia, United States, 23114
    - Bon Secours St. Francis Medical Center
  - Norfolk, Virginia, United States, 23502
    - USO - Virginia Oncology Associates
  - Reston, Virginia, United States, 20190
    - USO - Virginia Cancer Specialists
  - Roanoke, Virginia, United States, 24014
    - USO - Oncology & Hematology Associates of Southwest Virginia

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Have a diagnosis of ER+, HER2- early-stage, resected, invasive breast cancer without evidence of distant metastasis.
Participants must have received at least 24 months but not more than 60 months of any adjuvant ET, from time of adjuvant ET initiation.
Participants may have received (neo) adjuvant chemotherapy and/or targeted therapy with a CDK4/6- or PARP- inhibitor.
Must have an increased risk of disease recurrence based on clinical-pathological risk features.
Have a Performance Status of 0 or 1 on the Eastern Cooperative Oncology Group scale.
Have adequate organ function.

Exclusion Criteria:

Have any evidence of metastatic disease (including contralateral ALN) or inflammatory breast cancer at primary breast cancer diagnosis.
Participants with more than a 6-month consecutive gap in therapy during the course of prior adjuvant ET.
Participants who have completed or discontinued prior adjuvant ET >6 months prior to screening.
Participants with a history of previous breast cancer are excluded, with the exception of ipsilateral DCIS treated by locoregional therapy alone ≥5 years ago.
Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 180 days after the last dose of study intervention.
Participant has previously received ET of any duration for breast cancer prevention (tamoxifen or AIs) or raloxifene.
Participants with a history of any other cancer.
Have serious preexisting medical conditions that, in the judgment of the investigator, would preclude participation in this study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Imlunestrant Imlunestrant administered orally.	Drug: Imlunestrant Administered orally. Other Names: LY3484356
Active Comparator: Investigator's Choice of Endocrine Therapy Investigator's choice of tamoxifen, anastrozole, letrozole, or exemestane administered per local approved label.	Drug: Tamoxifen Administered per local approved label. Drug: Anastrozole Administered per local approved label. Drug: Letrozole Administered per local approved label. Drug: Exemestane Administered per local approved label.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Invasive Disease-Free Survival (IDFS) Time Frame: Randomization to recurrence or death from any cause (up to 10 years)	IDFS excluding second non-breast primary invasive cancers	Randomization to recurrence or death from any cause (up to 10 years)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall Survival (OS) Time Frame: Randomization to Death from Any Cause (up to 10 Years)	OS	Randomization to Death from Any Cause (up to 10 Years)
Distant Recurrence-Free Survival (DRFS) Time Frame: Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years)	DRFS	Randomization to Distant Recurrence or Death from Any Cause (up to 10 Years)
Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant Time Frame: Year 1, Month 2 to Month 4	PK: steady state plasma concentrations of imlunestrant	Year 1, Month 2 to Month 4
Change from Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning Time Frame: Visit 1 Day 1 up to end of Year 5	The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess multidimensional quality of life (QOL) in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Physical functioning was measured by items 1 to 5. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).	Visit 1 Day 1 up to end of Year 5
Change from Baseline in the EORTC QLQ-C30 Role Functioning Time Frame: Visit 1 Day 1 up to end of Year 5	The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Role functioning was measured by items 6 and 7. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).	Visit 1 Day 1 up to end of Year 5
Change from Baseline in the EORTC QLQ-C30 Global QOL Time Frame: Visit 1 Day 1 up to end of Year 5	The EORTC QLQ-C30 is a 30-question patient reported instrument used to assess the multidimensional QOL in cancer patients. It consists of 15 domains: 1 global QOL scale, 5 functional scales (Physical, Role, Cognitive, Emotional, Social), and 9 symptom scales/items (Fatigue, Nausea and Vomiting, Pain, Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, Financial Impact). Global QOL was measured by items 29 and 30. The sum score was linearly transformed to the range 0 - 100 as recommended by the EORTC (higher score is better).	Visit 1 Day 1 up to end of Year 5
Proportion of Time on Study Treatment with High Overall Adverse Event Burden Time Frame: Visit 1 Day 1 up to end of Year 5	FACT GP5 = Functional Assessment of Cancer Therapy - General Physical Well-being Item 5 (FACT GP5). High overall adverse event burden is defined as a score of 3 or 4 on a 5-point Likert scale. Higher scores represent higher symptom burden.	Visit 1 Day 1 up to end of Year 5

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer (EMBER-4)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 4, 2022

Primary Completion (Estimated)

October 1, 2027

Study Completion (Estimated)

March 1, 2032

Study Registration Dates

First Submitted

August 23, 2022

First Submitted That Met QC Criteria

August 23, 2022

First Posted (Actual)

August 24, 2022

Study Record Updates

Last Update Posted (Actual)

April 2, 2026

Last Update Submitted That Met QC Criteria

April 1, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

18459
J2J-MC-JZLH (Other Identifier: Eli Lilly and Company)
2022-501007-28 (EudraCT Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

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Clinical Trials on Imlunestrant

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