A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity (SURMOUNT-MMO)

January 9, 2026 updated by: Eli Lilly and Company

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults With Obesity

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

15374

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, 1405
        • Instituto Médico Especializado (IME)
      • Buenos Aires, Argentina, 1407
        • CEMEDIC
      • Buenos Aires, Argentina, C1419AHN
        • Asociacion de Beneficencia Hospital Sirio Libanes
      • Buenos Aires, Argentina, C1426ABP
        • Fundación Respirar
      • Buenos Aires, Argentina, C1440AAD
        • CENUDIAB
      • Buenos Aires, Argentina, C1120AAC
        • Centro Médico Viamonte
      • Buenos Aires, Argentina, 1012
        • CONEXA Investigacion Clinica S.A.
      • Buenos Aires, Argentina, C1023AAB
        • Stat Research S.A.
      • Buenos Aires, Argentina, C1056ABI
        • Centro de Investigaciones Metabólicas (CINME)
      • Buenos Aires, Argentina, C1405BUB
        • Consultorio de Investigacion Clinica EMO SRL
      • Buenos Aires, Argentina, C1425AGC
        • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
      • Buenos Aires, Argentina, 1417
        • Centro Privado de Medicina Familiar / Mindout Research
      • Buenos Aires, Argentina, C1128AAF
        • Mautalen Salud e Investigacion
      • Buenos Aires, Argentina, C1430CKE
        • Glenny Corp. S.A.
      • Buenos Aires, Argentina, C1056ABH
        • Investigaciones Medicas IMOBA SRL
      • C.a.b.a., Argentina, C1205AAO
        • CEMEDIAB
      • CABA, Argentina, C1060ABN
        • CEDIC
      • CABA, Argentina, C1061AAS
        • CIPREC
      • Capital, Argentina, X5008HHW
        • Centro Medico Privado CEMAIC
      • Córdoba, Argentina, 5000
        • Hospital San Roque
      • Córdoba, Argentina, X5002HWE
        • Centro de Investigaciones Clinicas Instituto del Corazon (CICIC)
      • Córdoba, Argentina, 5003DCE
        • Instituto Medico DAMIC
      • Córdoba, Argentina, 5016
        • Clinica Privada Velez Sarsfield
      • Córdoba, Argentina, 5000
        • Instituto de Investigaciones Clinicas Cordoba
      • Córdoba, Argentina, X5000EDC
        • Instituto Médico Strusberg
      • Córdoba, Argentina, X5000AVE
        • CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
      • Córdoba, Argentina, 5002
        • Sanatorio Privado Duarte Quirós
      • Córdoba, Argentina, 5006
        • Centro Medico Privado San Vicente Diabetes
      • Del Viso, Argentina, 1669
        • MICA - Medicina e Investigación Cardiometabólica
      • Godoy Cruz, Argentina, M5501ARP
        • CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
      • Granadero Baigorria, Argentina, 2152
        • Centro de Investigaciones Clínicas Baigorria
      • Lanús, Argentina, B1824KAJ
        • CIMeL Clinical Research
      • Mar del Plata, Argentina, 7600
        • Centro de Investigaciones Medicas Mar Del Plata
      • Mar del Plata, Argentina, 7600
        • Instituto de Investigaciones Clinicas Mar del Plata
      • Mar del Plata, Argentina, 7602
        • Omega Salud
      • Mendoza, Argentina, 5500
        • Instituto de Cardiología Wolff
      • Morón, Argentina, B1708EPE
        • CIAD Moron
      • Ramos Mejía, Argentina, 1704
        • DIM Clinica Privada
      • Rosario, Argentina, 2000
        • INECO Neurociencias Orono
      • Rosario, Argentina, 2000
        • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
      • Rosario, Argentina, 2000
        • Instituto Médico Catamarca IMEC
      • Rosario, Argentina, 2000
        • Instituto de Investigaciones Clinicas Rosario
      • Rosario, Argentina, 2000
        • Instituto Especialidades de la Salud Rosario
      • Rosario, Argentina, 2000
        • Laboratorio de Hemostasia y Trombosis
      • Rosario, Argentina, S2000DEJ
        • Fundacion Estudios Clinicos
      • Río Cuarto, Argentina, 5800
        • Instituto Medico Rio Cuarto
      • SAN M. de Tucuman, Argentina, T4000AXL
        • Centro de Investigaciones Medicas Tucuman
      • San Juan, Argentina, 5400
        • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
      • San Miguel de Tucumán, Argentina, 4000
        • Investigaciones Clinicas Tucuman
      • San Miguel de Tucumán, Argentina, 4000
        • Centro Modelo de Cardiología
      • San Miguel de Tucumán, Argentina, 4000
        • Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
      • San Nicolás, Argentina, 2900
        • Go Centro Medico San Nicolás
      • Santa Fe, Argentina, 3000
        • Centro de Diagnóstico y Rehabilitación (CEDIR)
      • Santa Fe, Argentina, 3000
        • Centro de Investigaciones Clinicas del Litoral
      • Santa Rosa, Argentina, 6300
        • Centro de Salud e Investigaciones Médicas
      • Santiago del Estero, Argentina, 4200
        • Sanatorio Norte
      • Temperley, Argentina, 1834
        • Centro de Investigaciones Médicas Temperley
      • Venado Tuerto, Argentina, 2600
        • Sanatorio San Martin
      • Villa Regina, Argentina, 8336
        • Clinica Central
      • Zárate, Argentina, B2800DGH
        • Instituto de Investigaciones Clínicas Zarate
  • Australia
      • Adelaide, Australia, 5000
        • Royal Adelaide Hospital
      • Adelaide, Australia, 5000
        • Nightingale Research
      • Blacktown, Australia, 2148
        • Paratus Clinical Research Western Sydney
      • Box Hill, Australia, 3128
        • Box Hill Hospital
      • Brisbane, Australia, 4029
        • Royal Brisbane and Women's Hospital
      • Brisbane, Australia, 4064
        • Core Research Group
      • Bruce, Australia, 2617
        • Paratus Clinical Research Canberra
      • Camberwell, Australia, 3124
        • Emeritus Research
      • Clayton, Australia, 3168
        • Victorian Heart Hospital
      • Geelong, Australia, 3220
        • Barwon Health
      • Heidelberg West, Australia, 3081
        • Austin Health - Repatriation Hospital
      • Hobart, Australia, 7000
        • Royal Hobart Hospital
      • Joondalup, Australia, 6027
        • Advara HeartCare Joondalup
      • Kanwal, Australia, 2259
        • Paratus Clinical Research Central Coast
      • Meadowbrook, Australia, 4131
        • Logan Hospital
      • Melbourne, Australia, 3004
        • Baker IDI Heart and Diabetes Institute - Melbourne
      • Merewether, Australia, 2291
        • The AIM Centre / Hunter Diabetes Centre
      • Murdoch, Australia, 6150
        • GenesisCare - Murdoch - Murdoch Drive
      • Oaklands Park, Australia, 5046
        • Southern Adelaide Diabetes & Endocrine Services
      • Sydney, Australia, 2006
        • University of Sydney - Charles Perkins Centre
      • Woodville, Australia, 5011
        • The Queen Elizabeth Hospital
  • Austria
      • Feldkirch, Austria, 6800
        • VIVIT
      • Graz, Austria, 8036
        • Medizinische Universitat Graz
      • Innsbruck, Austria, 6020
        • Medizinische Universitaet Innsbruck
      • Vienna, Austria, 1030
        • Klinik Landstraße
      • Vienna, Austria, 1060
        • Zentrum für klinische Studien Dr Hanusch Gmbh
      • Vienna, Austria, 1090
        • Universitaetsklinikum Allgemeines Krankenhaus Wien
      • Vienna, Austria, 1130
        • Klinik Hietzing
  • Belgium
      • Aalst, Belgium, 9300
        • AZORG Campus Aalst-Moorselbaan
      • Bonheiden, Belgium, 2820
        • Imelda General Hospital
      • Brussels, Belgium, 1070
        • Université Libre de Bruxelles - Hôpital Erasme
      • Edegem, Belgium, 2650
        • Antwerp University Hospital
      • Ghent, Belgium, 9000
        • UZ Gent
      • Hasselt, Belgium, 3500
        • Jessa Ziekenhuis
      • Leuven, Belgium, 3000
        • UZ Leuven
      • Ostend, Belgium, 8400
        • Az Damiaan vzw
      • Sint-Niklaas, Belgium, B-9100
        • AZ Nikolaas
  • Brazil
      • Brasília, Brazil, 71625-175
        • Centro de Pesquisa Clinica do Brasil
      • Brasília, Brazil, 72145-450
        • Chronos Pesquisa Clínica
      • Campinas, Brazil, 13060-080
        • Instituto de Pesquisa Clinica de Campinas
      • Campinas, Brazil, 13034-685
        • Centro de Pesquisa Sao Lucas
      • Campinas, Brazil, 13092133
        • Loema Instituto de Pesquisa Clinica
      • Curitiba, Brazil, 80030-480
        • Cline Research Center
      • Curitiba, Brazil, 80045170
        • Quanta Diagnóstico e Terapia
      • Curitiba, Brazil, 80810-040
        • Centro de Diabetes Curitiba
      • Fortaleza, Brazil, 60175-047
        • Centro De Diabetes Metabolismo E Endocrinologia
      • Fortaleza, Brazil, 60430-350
        • Centro de Pesquisas em Diabetes e Doenças Endócrino-metabólicas
      • Marília, Brazil, 17515-000
        • Instituto do Coracao de Marília
      • Niterói, Brazil, 24020-096
        • CHN - Complexo Hospitalar de Niterói
      • Porto Alegre, Brazil, 90430-001
        • Núcleo de Pesquisa Clínica do Rio Grande do Sul
      • Rio de Janeiro, Brazil, 22241-180
        • IBPClin - Instituto Brasil de Pesquisa Clínica
      • Santo André, Brazil, 09080-110
        • Pesquisare Saude
      • Santo André, Brazil, 09790790
        • Praxis Pesquisa Médica
      • São Bernardo do Campo, Brazil, 09715-090
        • Centro Multidisciplinar de Estudos Clinicos
      • São José dos Campos, Brazil, 12243-280
        • ISPEM - Instituto São Jose dos Campos em Pesquisas Medicas
      • São Paulo, Brazil, 01228-000
        • CPQuali Pesquisa Clínica
      • São Paulo, Brazil, 04266-010
        • CEPIC - Centro Paulista de Investigação Clínica
      • São Paulo, Brazil, 01228-200
        • CPCLIN
      • São Paulo, Brazil, 05403-000
        • Hospital das Clinicas FMUSP
      • São Paulo, Brazil, 01229-010
        • NotreDame Intermedica Saude S.A
      • São Paulo, Brazil, 01409-902
        • Hospital 9 De Julho
      • São Paulo, Brazil, 01236030
        • BR Trials - Ensaios Clinicos e Consultoria
      • São Paulo, Brazil, 01223-001
        • Instituto de Pesquisa Clinica
      • Vitória, Brazil, 29055450
        • CEDOES
      • Votuporanga, Brazil, 15500-269
        • INTEGRAL Pesquisa e Ensino
  • Canada
      • Brampton, Canada, L6S 0C6
        • LMC Clinical Research Inc. (Brampton)
      • Calgary, Canada, T2V 4J2
        • C-health Research
      • Chicoutimi, Canada, G7H 7K9
        • Ecogene-21
      • Courtice, Canada, L1E 2J5
        • Med Trust Research
      • Greater Sudbury, Canada, P3C 1X3
        • Medicor Research
      • Greater Sudbury, Canada, P3E 5J1
        • Health Sciences North
      • Greenfield Park, Canada, J4V 2G8
        • Viacar Recherche Clinique
      • Halifax, Canada, B3H 1V7
        • NSHA-QEII Health Sciences Centre-Dickson Bldg
      • Hamilton, Canada, L8L 5G4
        • Premier Clinical Trial Network
      • Hamilton, Canada, L8L 5G8
        • The Wharton Medical Clinic Clinical Trials Inc
      • Lévis, Canada, G6W 0M5
        • Manna Research
      • Moncton, Canada, E1G 1A7
        • G A Research Associates
      • Montreal, Canada, H3M 1L3
        • Power Clinical Research
      • New Westminster, Canada, V3L 3W4
        • Fraser Clinical Trials Inc
      • North York, Canada, M6B 3H7
        • North York Diagnostic and Cardiac Centre
      • Oshawa, Canada, L1J 2K9
        • Centricity Research Oshawa
      • Pointe-Claire, Canada, H9R 4S3
        • Manna Research Montreal
      • Québec, Canada, G3K 2P8
        • Alpha Recherche Clinique
      • Québec, Canada, G2J 0C4
        • Alpha Recherche Clinique
      • Sarnia, Canada, N7T 4X3
        • Bluewater Clinical Research Group Inc.
      • Sherwood Park, Canada, T8H 0N2
        • Synergy Medical Clinic
      • Terrebonne, Canada, J6X 4P7
        • Centre de Medecine Metabolique de Lanaudiere (CMML)
      • Toronto, Canada, M9V 4B4
        • Dr. Anil K. Gupta Medicine Professional Corporation
      • Toronto, Canada, M4G 3E8
        • LMC Clinical Research Inc. (Bayview)
      • Toronto, Canada, M6G 1M2
        • Diabetes Heart Research Centre
      • Victoria, Canada, V8V 4A1
        • Dr. M.B. Jones Inc.
  • China
      • Beijing, China, 101200
        • Beijing Pinggu District Hospital
      • Beijing, China, 100034
        • Peking University People's Hospital
      • Beijing, China, 100050
        • Beijing Friendship Hospital Affiliate of Capital University
      • Changchun, China, 130033
        • China-Japan Union Hospital
      • Changping, China, 102202
        • Beijing Tsinghua Changgung Hospital
      • Chengdu, China, 610041
        • West China Hospital Sichuan University
      • Chengdu, China, 611130
        • Chengdu Fifth People's Hospital
      • Chongqing, China, 400014
        • Chongqing General Hospital
      • Haikou, China, 570311
        • Hainan General Hospital
      • Harbin, China, 150001
        • The Fourth Affiliated Hospital of Harbin Medical University
      • Hengshui Shi, China, 053000
        • Hebei Medical University - Harrison International Peace Hospital
      • Huai'an, China, 223300
        • First Huai'an Hospital Affiliated to Nanjing Medical University
      • Huzhou, China, 313000
        • Huzhou Central Hospital
      • Jinan, China, 250013
        • Jinan Central Hospital
      • Kunming, China, 650034
        • The First People's Hospital of Yunnan Province
      • Lanzhou, China, 730030
        • Lanzhou University Second Hospital
      • Luoyang Shi, China, 471003
        • The First Affiliated Hospital of Henan University of Science &Technology
      • Nanchang, China, 330008
        • The Third Hospital of Nanchang
      • Nanjing, China, 210006
        • Nanjing First Hospital
      • Nanjing, China, 210011
        • The Second Affiliated Hospital of Nanjing Medical University
      • Nanjing, China, 211100
        • Nanjing Medical University - Nanjing Jiangning Hospital
      • Sanya, China, 572000
        • Third People's Hospital of Hainan Province
      • Shanghai, China, 200023
        • Shanghai 9th People hospital
      • Shenyang, China, 110000
        • The People's Hospital of Liaoning Province
      • Siping, China, 136000
        • Siping Central People's Hospital
      • Tianjin, China, 300052
        • Tianjin Medical University General Hospital
      • Tianjin, China, 300121
        • Tianjin People' s Hospital
      • Wuhan, China, 430030
        • Wuhan University Medical College - Hubei Zhongshan Hospital
      • Wuxi, China, 214023
        • Wuxi People's Hospital
      • Xi'an, China, 710061
        • The First Affiliated Hospital of Xi'an Jiaotong University
      • Xi'an, China, 710068
        • Shaanxi Provincial People's Hospital
      • Zhengzhou, China, 450014
        • The Second Affiliated Hospital of Zhengzhou University
  • Czechia
      • Brandýs nad Labem-Stará Boleslav, Czechia, 250 01
        • Kardiologicka ambulance
      • Havířov, Czechia, 736 01
        • Asclepiades
      • Hodonín, Czechia, 695 01
        • CTC Hodonin s.r.o.
      • Jindřichův Hradec, Czechia, 377 38
        • GAE s.r.o.
      • Olomouc, Czechia, 779 00
        • PreventaMed
      • Ostrava, Czechia, 700 30
        • Kardiologicka a Angiologicka Ambulance
      • Prague, Czechia, 149 00
        • Nefrologie
      • Prague, Czechia, 150 00
        • FaraCol s.r.o.
      • Prague, Czechia, 158 00
        • Poliklinika Lípa Centrum
      • Příbram, Czechia, 261 01
        • Kardiologicka ambulance s.r.o.
      • Slaný, Czechia, 274 01
        • Angionika
      • Trutnov, Czechia, 541 01
        • Kardiologicka ambulance MUDr. Ferkl s.r.o.
      • Zlín, Czechia, 760 01
        • Cardio Research, s.r.o
      • Český Krumlov, Czechia, 381 01
        • Nemocnice Cesky krumlov
  • France
      • Corbeil-Essonnes, France, 91106
        • Centre Hospitalier Sud Francilien
      • La Tronche, France, 38700
        • Chu Grenoble Alpes
      • Le Coudray, France, 28630
        • Centre Hospitalier Louis Pasteur
      • Le Creusot, France, 71200
        • Hôtel-Dieu du Creusot - site Harfleur
      • Limoges, France, 87042
        • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
      • Nice, France, 06202
        • Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
      • Paris, France, 75015
        • Hôpital Européen Georges Pompidou
      • Paris, France, 75010
        • Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière
      • Pierre-Bénite, France, 69494 Cédex
        • Centre Hospitalier Lyon Sud
      • Saint-Herblain, France, 44800
        • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
      • Strasbourg, France, 67098
        • CHU Strasbourg-Hautepierre
      • Toulouse, France, 31059
        • CHU Rangueil
      • Vénissieux, France, 69200
        • Groupe Hospitalier Mutualiste Les Portes du Sud
  • Germany
      • Bad Homburg, Germany, 61348
        • Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair
      • Bad Oeynhausen, Germany, 32545
        • Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
      • Berlin, Germany, 10787
        • Klinische Forschung Berlin
      • Dresden, Germany, 01307
        • Universitaetsklinikum Carl Gustav Carus Dresden
      • Essen, Germany, 45136
        • InnoDiab Forschung GmbH
      • Essen, Germany, 45355
        • Praxis am Markt - Dr. Bernd Becker
      • Essen, Germany, 45355
        • Medizentrum Essen Borbeck
      • Frankfurt, Germany, 60590
        • Universitätsklinikum Frankfurt Goethe-Universität
      • Frankfurt, Germany, 60596
        • ClinPhenomics CVC GmbH
      • Freiburg im Breisgau, Germany, 79106
        • Universitaetsklinikum Freiburg
      • Hamburg, Germany, 22607
        • Diabeteszentrum Hamburg West
      • Hamburg, Germany, 22143
        • Velocity Clinical Research Hamburg GmbH
      • Leipzig, Germany, 04107
        • AmBeNet GmbH
      • Ludwigshafen am Rhein, Germany, 67059
        • Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz
      • Lübeck, Germany, 23562
        • Universität zu Lübeck - Institut für Endokrinologie und Diabetes
      • Münster, Germany, 48145
        • Institut für Diabetesforschung GmbH Münster
      • Pirna, Germany, 01796
        • Arztpraxis Christine Kosch Pirna
      • Saint Ingbert, Germany, 66386
        • Zentrum für klinische Studien
      • Tübingen, Germany, 72076
        • Universitaetsklinikum Tuebingen
      • Villingen-Schwenningen, Germany, 78048
        • Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob
      • Wangen, Germany, 88239
        • Praxis Sauter & Sauter & Vorbach
  • Greece
      • Athens, Greece, 11527
        • General Hospital of Athens Laiko
      • Athens, Greece, 11527
        • General Hospital of Athens "G. Gennimatas"
      • Athens, Greece, 151 25
        • Athens Medical Center
      • Chaïdári, Greece, 12462
        • Attikon General University Hospital
      • Heraklion, Greece, 71110
        • University General Hospital of Heraklion
      • Ioannina, Greece, 45500
        • University Hospital of Ioannina
      • Lamia, Greece, 351 00
        • General Hospital of Lamia
      • Larissa, Greece, 41110
        • University General Hospital of Larissa
      • Palaió Fáliro, Greece, 17562
        • Iatriko Paleou Falirou Medical Center
      • Thermi,Thessaloniki, Greece, 570 01
        • Thermi Clinic
      • Thessaloniki, Greece, 546 36
        • Ahepa University General Hospital of Thessaloniki
      • Thessaloniki, Greece, 546 45
        • EUROMEDICA General Clinic of Thessaloniki
      • Thessaloniki, Greece, 54642
        • Ippokrateio General Hospital of Thessaloniki
      • Thessaloniki, Greece, 564 03
        • Papageorgiou General Hospital Of Thessaloniki
  • Hungary
      • Balatonfüred, Hungary, 8230
        • DRC Gyógyszervizsgáló Központ
      • Budapest, Hungary, 1033
        • Clinexpert Kft.
      • Budapest, Hungary, 1036
        • Óbudai Egészségügyi Centrum
      • Budapest, Hungary, 1213
        • TRANTOR'99 Bt. Anyagcsere Centrum
      • Budapest, Hungary, H1171
        • Strazsahegy Medicina Bt.
      • Budapest, Hungary, 1032
        • Szent Margit Rendelintézet
      • Budapest, Hungary, 1083
        • Semmelweis University
      • Budapest, Hungary
        • Bajcsy-Zsilinszky Kórház
      • Budapest, Hungary, 1134
        • Magyar Honvedseg Egeszsegugyi Kozpont
      • Budapest, Hungary, 1097
        • Dél-Pesti Centrumkórház
      • Budapest, Hungary, H-1046
        • Újpesti Egészségügyi Nonprofit Kft
      • Debrecen, Hungary, 4032
        • Debreceni Egyetem Klinikai Kozpont
      • Kistarcsa, Hungary, 2143
        • Kistarcsai Flor Ferenc Korhaz
      • Komárom, Hungary, 2900
        • Selye János Kórház
      • Nagykanizsa, Hungary, 8800
        • Kanizsai Dorottya Korhaz
      • Szolnok, Hungary, 5000
        • Allergo-Derm Bakos Kft
      • Szombathely, Hungary, 9700
        • Markusovszky Egyetemi Oktatokorhaz
      • Veszprém, Hungary, 8200
        • Minoseg Orvoscsoport Kft
  • India
      • Ahmedabad, India, 380052
        • Gujarat Endocrin Pvt Ltd
      • Bikaner, India, 334001
        • Sardar Patel Medical College
      • Hyderabad, India, 500012
        • Osmania General Hospital
      • Lucknow, India, 226003
        • King George's Medical University
      • Ludhiana, India, 141001
        • Dayanand Medical College and Hospital
      • Mumbai, India, 400008
        • Sir JJ Group of Hospitals
      • Nagpur, India, 440001
        • Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)
      • New Delhi, India, 110002
        • G.B. Pant Institute of Postgraduate Medical Education & Research
      • Surat, India, 395002
        • Nirmal Hospital Pvt Ltd.
      • Surat, India, 395002
        • Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute
  • Israel
      • Ashkelon, Israel, 7830604
        • Barzilai Medical Center
      • Haifa, Israel, 3109601
        • Rambam Health Care Campus
      • Haifa, Israel, 3515209
        • Linn Medical Center
      • Holon, Israel, 5810001
        • Edith Wolfson Medical Center
      • Jerusalem, Israel, 9112001
        • Hadassah Medical Center
      • Kfar Saba, Israel, 4428164
        • Meir Medical Center
      • Nahariya, Israel, 2210001
        • Galilee Medical Center
      • Petah Tikva, Israel, 49100
        • Rabin Medical Center
      • Petah Tikva, Israel, 4941492
        • Rabin Medical Center
      • Petah Tikva, Israel, 4937211
        • Rabin Medical Center - Hasharon Campus
      • Ramat Gan, Israel, 5262100
        • Sheba Medical Center
      • Rehovot, Israel, 7610001
        • Kaplan Medical Center
      • Sakhnin, Israel, 3081000
        • Clalit Health Services - Sakhnin Community Clinic
      • Tel Aviv, Israel, 6423906
        • Sourasky Medical Center
      • Ẕerifin, Israel, 70300
        • Yitzhak Shamir Medical Center
  • Italy
      • Bari, Italy, 70124
        • A.O.U.C. Policlinico di Bari
      • Bologna, Italy, 40138
        • IRCCS - AOU di Bologna
      • Ferrara, Italy, 44124
        • Azienda Ospedaliero Universitaria S.Anna
      • Florence, Italy, 50134
        • Azienda Ospedaliera Universitaria Careggi
      • Latina, Italy, 04100
        • Ospedale Santa Maria Goretti
      • Padua, Italy, 35128
        • Azienda Ospedale - Università Padova
      • Palermo, Italy, 90127
        • Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli
      • Palermo, Italy, 90127
        • A.O.U. Policlinico Paolo Giaccone
      • Pisa, Italy, 56126
        • Azienda Ospedaliera Universitaria Pisana
      • Pisa, Italy, 56124
        • Azienda Ospedaliera Universitaria Pisana
      • Rome, Italy, 00133
        • Fondazione Policlinico Tor Vergata
      • Rome, Italy, 00128
        • Fondazione Policlinico Universitario Campus Bio-Medico
      • San Donato Milanese, Italy, 20097
        • IRCCS Policlinico San Donato
      • San Fermo della Battaglia, Italy, 22042
        • Presidio Ospedaliero Ospedale Sant'Anna
      • Torino, Italy, 10126
        • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
  • Japan
      • Chūōku, Japan, 103-0027
        • Tokyo-Eki Center-building Clinic
      • Fukuoka, Japan, 811-0213
        • Fukuoka Wajiro Hospital
      • Izumisano, Japan, 598-8577
        • Rinku General Medical Center
      • Kyoto, Japan, 607-8062
        • Rakuwakai Otowa Hospital
      • Minatoku, Japan, 108-0073
        • Tokyo Saiseikai Central Hospital
      • Onga-gun, Japan, 807-0051
        • Fukuoka Shinmizumaki Hospital
      • Osaka, Japan, 530-0001
        • AMC Nishiumeda Clinic
      • Osaka, Japan, 535-0002
        • Shimada Clinic - Osaka
      • Uji, Japan, 611-0041
        • Uji-Tokushukai Medical Center
  • Mexico
      • Aguascalientes, Mexico, 20230
        • Fundación Cardiovascular de Aguascalientes A.C.
      • Chihuahua City, Mexico, 31217
        • Investigacion En Salud Y Metabolismo Sc
      • Ciudad Madero, Mexico, 89440
        • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
      • Cuauhtémoc, Mexico, 06700
        • Centro de Investigación y Gastroenterología
      • Cuernavaca, Mexico, 62250
        • Instituto de Diabetes, Obesidad y Nutricion
      • Culiacán, Mexico, 80230
        • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C.
      • Culiacán, Mexico, 80200
        • Medical Group Culiacan
      • Durango, Mexico, 34000
        • Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
      • Guadalajara, Mexico, 44130
        • Diseno y Planeacion en Investigacion Medica
      • Guadalajara, Mexico, 44670
        • Private Practice - Dr. Arechavaleta Granell Maria del Rosario
      • Guadalajara, Mexico, 44670
        • Private Practice - Dr. Francisco Gerardo Padilla
      • Guadalajara, Mexico, 04460
        • Instituto Jalisciense de Investigacion en Diabetes y Obesidad
      • Guadalajara, Mexico, 44160
        • Centro de Investigacion Medica Integral
      • Guadalajara, Mexico, 44340
        • Universidad de Guadalajara
      • Guadalajara, Mexico, 44650
        • Clinica de Investigacion en Reumatologia y Obesidad S. C.
      • Guadalajara, Mexico, 44670
        • CICEJ Centro de Investigación Clínica Endocrinológica de Jalisco S.C
      • Guadalajara, Mexico, 44670
        • Unidad de Investigación Clínica y Atención Médica HEPA
      • Guadalajara, Mexico, 44670
        • Virgen Cardiovascular Research SC
      • Hermosillo, Mexico, 83270
        • Investigación Médica Sonora, S.C.
      • Mexicali, Mexico, 21200
        • Centro de Investigacion en Artritis y Osteoporosis SC
      • Mexico City, Mexico, 14080
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
      • Mexico City, Mexico, 06090
        • Hospital de Jésus, I.A.P.
      • Mexico City, Mexico, 11650
        • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
      • Mexico City, Mexico, 03100
        • RM Pharma Specialists
      • Mexico City, Mexico, 06760
        • Caimed Investigacion En Salud S.A. de C.V.
      • Monterrey, Mexico, 64460
        • UBAM Unidad Biomedica Avanzada Monterrey
      • Monterrey, Mexico, 64460
        • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
      • Monterrey, Mexico, 64718
        • Eukarya PharmaSite
      • Monterrey, Mexico, 64060
        • Cardiolink Clin Trials
      • Monterrey, Mexico, 64060
        • IMED Internal Medicine Clin Trials
      • Monterrey, Mexico, 66460
        • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
      • Mérida, Mexico, 97000
        • Eme Red Hospitalaria
      • Mérida, Mexico, 97070
        • Medical Care and Research SA de CV
      • Querétaro, Mexico, 76000
        • Centro de Estudios Clínicos de Querétaro (CECLIQ)
      • Querétaro, Mexico, 76100
        • PanAmerican Clinical Research - Querétaro - Avenida Antea
      • San Nicolás de los Garza, Mexico, 66465
        • Unidad Médica para la Salud Integral
      • Tijuana, Mexico, 22500
        • Centro de Investigacion Cardiovascular y Metabolica
      • Veracruz, Mexico, 91910
        • Arké SMO S.A de C.V
      • Veracruz, Mexico, 91851
        • Instituto Veracruzano en Investigación Clínica S.C.
      • Xalapa, Mexico, 91193
        • Consultorio de Medicina Especilizada del Sector Privado
      • Zapopan, Mexico, 44260
        • Centro de Investigacion Medica de Occidente, S.C.
  • Netherlands
      • Almelo, Netherlands, 7609 PP
        • Ziekenhuisgroep Twente, locatie Almelo
      • Amersfoort, Netherlands, 3813 TZ
        • Meander Medisch Centrum
      • Delft, Netherlands, 2625 AD
        • Reinier de Graaf Ziekenhuis, locatie Delft
      • Dordrecht, Netherlands, 3318 AT
        • Albert Schweitzer Ziekenhuis, locatie Dordwijk
      • Emmen, Netherlands, 7824 AA
        • Treant, locatie Scheper Ziekenhuis
      • Groningen, Netherlands, 9728 NT
        • Martini Ziekenhuis
      • Groningen, Netherlands, 9713 GH
        • General Practitioners Research Institute (GPRI)
      • Haarlem, Netherlands, 2035 RC
        • Spaarne Gasthuis, Haarlem Zuid
      • Helmond, Netherlands, 5707 HA
        • Elkerliek Ziekenhuis
      • Rotterdam, Netherlands, 3045 PM
        • Franciscus Gasthuis & Vlietland, Locatie Gasthuis
      • Tiel, Netherlands, 4002 WP
        • Ziekenhuis Rivierenland
  • Poland
      • Bialystok, Poland, 15-351
        • Osteo Medic sc A. Racewicz, J. Supronik
      • Bialystok, Poland, 15-404
        • Legeartis - Poradnie Specjalistyczne
      • Bialystok, Poland, 15445
        • Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
      • Bydgoszcz, Poland, 85-231
        • NZOZ Centrum Medyczne KERmed
      • Bydgoszcz, Poland, 85-163
        • Centrum Medyczne Neuromed
      • Bydgoszcz, Poland, 85-605
        • INTERCOR
      • Chorzów, Poland, 41-500
        • Diab Serwis Popenda Spółka Jawna
      • Elblag, Poland, 82-300
        • Centrum Kliniczno-Badawcze
      • Elblag, Poland, 82-300
        • Ambulatorium sp. z o.o.
      • Gdansk, Poland, 80-546
        • Centrum Badan Klinicznych PI-House sp. z o.o.
      • Krakow, Poland, 31-261
        • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
      • Lodz, Poland, 90338
        • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
      • Lublin, Poland, 20-333
        • Gabinety TERPA
      • Lublin, Poland, 20-044
        • CenterMed Lublin NZOZ
      • Lublin, Poland, 20-718
        • Ekamed
      • Poznan, Poland, 61-251
        • Gaja Poradnie Lekarskie Maciej Wiza
      • Poznan, Poland, 61-853
        • Nzoz Neuro-Kard Ilkowski i Partnerzy SPL
      • Radom, Poland, 26-600
        • Centrum Medyczne "Diabetika"
      • Ruda Śląska, Poland, 41-709
        • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
      • Warsaw, Poland, 02-507
        • Centralny Szpital Kliniczny MSW w Warszawie
      • Warsaw, Poland, 00-710
        • NBR Polska
      • Wroclaw, Poland, 50-403
        • Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej
      • Wroclaw, Poland, 50-981
        • 4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
  • Puerto Rico
      • Bayamón, Puerto Rico, 00959
        • Advanced Clinical Research, LLC
      • Dorado, Puerto Rico, 00646
        • Dorado Medical Complex
      • Dorado, Puerto Rico, 00646
        • Puerto Rico Health Institute
      • Manatí, Puerto Rico, 00674
        • Manati Center for Clinical Research
      • Ponce, Puerto Rico, 00717
        • Puerto Rico Medical Research
      • Ponce, Puerto Rico, 00717
        • Research and Cardiovascular Corp.
      • San Juan, Puerto Rico, 00917
        • GCM Medical Group, PSC - Hato Rey Site
  • Romania
      • Bacau, Romania, 600274
        • SC Minimed SRL
      • Baia Mare, Romania, 430222
        • CMI DNBM Dr. Pop Lavinia
      • Baia Mare, Romania, 430124
        • CMI Cardiologie - Dr. Mercea Corina Delia
      • Brasov, Romania, 500283
        • C.M.D.T.A. Neomed
      • Bucharest, Romania, 011053
        • Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
      • Bucharest, Romania, 010507
        • Nicodiab
      • Bucharest, Romania, 013764
        • Centrul Medical NutriLife
      • Bucharest, Romania, 50538
        • Centrul Medical Endocrinologie si Diabet Dr. Paveliu
      • Craiova, Romania, 200642
        • Spitalul Clinic Județean de Urgență
      • Craiova, Romania, 200513
        • S.C. Cardiomed S.R.L.
      • Galați, Romania, 800291
        • Diamed Obesity
      • Galați, Romania, 800001
        • Milena Sante
      • Iași, Romania, 700547
        • Centrul Medical Consultmed
      • Mangalia, Romania, 905500
        • Gama Diamed
      • Oradea, Romania, 410147
        • Diabdana
      • Oradea, Romania, 410159
        • Centrul Medical Grandmed
      • Piteşti, Romania, 110437
        • Sal Med Srl
      • Ploieşti, Romania, 100561
        • Dianutrilife Medica
      • Satu Mare, Romania, 440055
        • Clinica Korall
      • Sibiu, Romania, 550371
        • Policlinica Astra Sibiu
      • Timișoara, Romania, 300288
        • Cabinet Medical Dr.Geru
      • Timișoara, Romania, 300310
        • Institutul de Boli Cardiovasculare Timisoara
      • Timișoara, Romania, 300362
        • Centrul Medical Medicalis
      • Târgu Mureş, Romania, 540142
        • Centrul Medical Mediab
      • Târgu Mureş, Romania, 540143
        • Private Practice - Dr. Cristian Podoleanu
  • Slovakia
      • Bratislava, Slovakia, 831 03
        • MediTask
      • Dolný Kubín, Slovakia, 02601
        • JM-Interna s.r.o
      • Martin, Slovakia, 036 01
        • AMBORA s.r.o. Interna ambulancia
      • Nové Zámky, Slovakia, 940 01
        • FUNKYSTUFF s.r.o.
      • Piešťany, Slovakia, 921 01
        • BENIMED s.r.o. Kardiologicka ambulancia
      • Púchov, Slovakia, 020 01
        • DIA-MED CENTRUM s.r.o.
      • Žilina, Slovakia, 010 01
        • PENTES s.r.o. Kardiologicka ambulancia
  • South Korea
      • Ansan-si, South Korea, 15355
        • Korea University Ansan Hospital
      • Busan, South Korea, 49241
        • Pusan National University Hospital
      • Seongnam, South Korea, 13620
        • Seoul National University Bundang Hospital
      • Seoul, South Korea, 06351
        • Samsung Medical Center
      • Seoul, South Korea, 03722
        • Severance Hospital, Yonsei University Health System
      • Seoul, South Korea, 02841
        • Korea University Anam Hospital
      • Seoul, South Korea, 02447
        • Kyung Hee University Hospital
      • Wŏnju, South Korea, 26426
        • WonJu Severance Christian Hospital
  • Spain
      • A Coruña, Spain, 15006
        • CHUAC-Complejo Hospitalario Universitario A Coruña
      • Almería, Spain, 04009
        • Centro Periférico de Especialidades Bola Azul
      • Alzira, Spain, 46600
        • Hospital Universitario de La Ribera
      • Barcelona, Spain, 08036
        • Hospital Clinic de Barcelona
      • Barcelona, Spain, 08035
        • Hospital Universitari Vall d'Hebron
      • Bilbao, Spain, 48013
        • Osi Bilbao-Basurto
      • Ferrol, Spain, 15405
        • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
      • Granada, Spain, 18016
        • Hospital Universitario San Cecilio
      • León, Spain, 24008
        • Complejo Asistencial Universitario de León - Hospital de León
      • Lleida, Spain, 25198
        • Hospital Universitario Arnau de Vilanova de Lleida
      • Madrid, Spain, 28034
        • Hospital Universitario Ramon y Cajal
      • Madrid, Spain, 28040
        • Hospital Universitario Fundacion Jimenez Diaz
      • Madrid, Spain, 28009
        • Hospital General Universitario Gregorio Marañon
      • Málaga, Spain, 29010
        • Hospital Universitario Virgen de la Victoria
      • Málaga, Spain, 29004
        • Hospital Quirón Málaga
      • Oviedo, Spain, 33011
        • Hospital Universitario Central de Asturias
      • Palma de Mallorca, Spain, 07014
        • Clínica Juaneda
      • Pamplona, Spain, 31008
        • Clinica Universidad de Navarra
      • Pozuelo de Alarcón, Spain, 28223
        • Hospital Universitario Quirónsalud Madrid
      • San Cristóbal de La Laguna, Spain, 38320
        • Hospital Universitario de Canarias
      • Sanlúcar de Barrameda, Spain, 11540
        • Hospital Virgen del Camino
      • Santander, Spain, 39008
        • Hospital Universitario Marqués de Valdecilla
      • Seville, Spain, 41003
        • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
      • Seville, Spain, 41950
        • Vithas Hospital Sevilla
      • Seville, Spain, 41010
        • Hospital Quiron Infanta Luisa
      • Valencia, Spain, 46010
        • Hospital Clinico de Valencia
      • Valencia, Spain, 46017
        • Hospital Universitario Doctor Peset
      • Valencia, Spain, 46014
        • Hospital General Universitario de Valencia
      • Villamartín, Spain, 11650
        • Hospital Virgen de las Montañas
  • Taiwan
      • Hsinchu, Taiwan, 300
        • HsinChu MacKay Memorial Hospital
      • Kaohsiung City, Taiwan, 807
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Chang Gung Memorial Hospital at Kaohsiung
      • New Taipei City, Taiwan, 220
        • Far Eastern Memorial Hospital
      • New Taipei City, Taiwan, 235
        • Taipei Medical University Shuang Ho Hospital
      • New Taipei City, Taiwan, 251
        • Mackay Memorial Hospital -Tamshui Branch
      • Tainan, Taiwan, 704
        • National Cheng Kung University Hospital
      • Tainan, Taiwan, 71004
        • Chi Mei Medical Center
      • Taipei, Taiwan, 11217
        • Taipei Veterans General Hospital
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital
      • Taipei, Taiwan, 114
        • Tri-Service General Hospital
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01790
        • Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi
      • Ankara, Turkey (Türkiye), 06230
        • Ankara Universitesi Tip Fakultesi Hastanesi
      • Antalya, Turkey (Türkiye), 07070
        • Akdeniz Universitesi Hastanesi
      • Aydin, Turkey (Türkiye), 09100
        • Adnan Menderes University Medical Faculty
      • Balçova, Turkey (Türkiye), 35340
        • Dokuz Eylul Universitesi
      • Bornova, Turkey (Türkiye), 35100
        • Ege Universitesi Hastanesi
      • Denizli, Turkey (Türkiye), 20070
        • Pamukkale University Medical Faculty, Fahri Goksin Oncology Centre
      • Gaziantep, Turkey (Türkiye), 27310
        • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
      • Kadıköy, Turkey (Türkiye), 34722
        • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
      • Kayseri, Turkey (Türkiye), 38030
        • Erciyes University Medical Faculty
      • Konya, Turkey (Türkiye), 42080
        • Necmettin Erbakan Meram Medical Fac.
      • Malatya, Turkey (Türkiye), 44000
        • İnönü Üniversitesi Turgut Özal Tıp Merkezi
      • Mersin, Turkey (Türkiye), 33343
        • Mersin University
      • Sarıyer, Turkey (Türkiye), 34396
        • Sisli Etfal Training and Research Hospital
      • Sivas, Turkey (Türkiye), 58140
        • Cumhuriyet Universitesi
      • Yüreğir, Turkey (Türkiye), 01250
        • Baskent University Dr. Turgut Noyan Research and Training Center
      • Yıldırım, Turkey (Türkiye), 16310
        • Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi
  • United Kingdom
      • Blackburn, United Kingdom, BB2 1AX
        • Oakenhurst Medical Practice
      • Bristol, United Kingdom, BS10 5NB
        • Southmead Hospital
      • Coventry, United Kingdom, CV2 2DX
        • University Hospital Coventry & Warwickshire
      • Dundee, United Kingdom, DD1 9SY
        • Ninewells Hospital and Medical School
      • Ely, United Kingdom, CB7 5JD
        • Staploe Medical Centre
      • Fowey, United Kingdom, PL23 1DT
        • Fowey River Practice
      • Hull, United Kingdom, HU3 2JZ
        • Hull Royal Infirmary
      • Ipswich, United Kingdom, IP4 5PD
        • Ipswich Hospital
      • Leicester, United Kingdom, LE5 4PW
        • Leicester General Hospital
      • Newcastle upon Tyne, United Kingdom, NE1 4LP
        • Royal Victoria Infirmary
      • Plymouth, United Kingdom, PL5 3JB
        • Knowle House Surgery
      • Rotherham, United Kingdom, S65 1DA
        • Wickersley Health Centre - Clifton Medical Centre
      • Stevenage, United Kingdom, SG1 4AB
        • Lister Hospital
      • Torpoint, United Kingdom, PL11 2TB
        • Rame Group Practice
      • Truro, United Kingdom, TR1 3LJ
        • The Royal Cornwall Hospital
  • United States
    • Arizona
      • Gilbert, Arizona, United States, 85296
        • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
      • Mesa, Arizona, United States, 85206
        • Aventiv Research
      • Phoenix, Arizona, United States, 85018
        • Elite Clinical Studies
      • Tucson, Arizona, United States, 85741
        • Pima Heart
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • KLR Business Group, Inc. dba Arkansas Clinical Research
    • California
      • Anaheim, California, United States, 92806
        • Smart Cures Clinical Research
      • Apple Valley, California, United States, 92307
        • Kidney & Hypertension Center - Apple Valley
      • Canoga Park, California, United States, 91303
        • Hope Clinical Research, Inc.
      • Concord, California, United States, 94520
        • John Muir Physician Network Research Center
      • Escondido, California, United States, 92025
        • Neighborhood Healthcare Institute of Health
      • Fountain Valley, California, United States, 92708
        • HB Clinical Trials - Fountain Valley
      • Huntington Park, California, United States, 90255
        • Valiance Clinical Research
      • La Jolla, California, United States, 92037
        • Scripps Whittier Diabetes Institute
      • La Mesa, California, United States, 91942
        • Velocity Clinical Research, San Diego
      • Lancaster, California, United States, 93534
        • First Valley Medical Group
      • Long Beach, California, United States, 90806
        • Long Beach Clinical Trials
      • Norco, California, United States, 92860
        • Infinity Clinical Research - Norco
      • Northridge, California, United States, 91324
        • California Medical Research Associates
      • Orange, California, United States, 92868
        • University of California Irvine Medical Center
      • Orange, California, United States, 92868
        • Diabetes Associates Medical Group
      • Oxnard, California, United States, 93030
        • FOMAT Medical Research
      • Palm Springs, California, United States, 92262
        • Desert Oasis Healthcare Medical Group
      • Pomona, California, United States, 91767
        • Dream Team Clinical Research
      • Rancho Cucamonga, California, United States, 91730
        • Rancho Cucamonga Clinical Research
      • Riverside, California, United States, 92503
        • Artemis Institute for Clinical Research
      • San Diego, California, United States, 92103
        • Artemis Institute for Clinical Research
      • San Diego, California, United States, 92120
        • Acclaim Clinical Research
      • Santa Ana, California, United States, 92704
        • Velocity Clinical Research, Santa Ana
      • Tarzana, California, United States, 91356
        • Valiance Clinical Research
      • Torrance, California, United States, 90502
        • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
      • Walnut Creek, California, United States, 94598
        • Diablo Clinical Research, Inc.
      • Westlake Village, California, United States, 91361
        • Millennium Clinical Trials
    • Colorado
      • Aurora, Colorado, United States, 80045
        • University of Colorado Anschutz Medical Campus
      • Colorado Springs, Colorado, United States, 80906
        • Optum- Southwestern
      • Denver, Colorado, United States, 80210
        • Kidney Associates of Colorado
      • Golden, Colorado, United States, 80401
        • OptumCare Clinical Trials, LLC
    • Connecticut
      • Milford, Connecticut, United States, 06460
        • Clinical Research Consulting
      • Stamford, Connecticut, United States, 06905
        • Cardiology Associates of Fairfield County, P.C.
      • Waterbury, Connecticut, United States, 06708
        • Chase Medical Research, LLC
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Excel Medical Clinical Trials
      • Boynton Beach, Florida, United States, 33436
        • Encore Medical Research of Boynton Beach
      • Clearwater, Florida, United States, 33765
        • Clinical Research of West Florida, Inc. (Clearwater)
      • Fleming Island, Florida, United States, 32003
        • Northeast Research Institute (NERI)
      • Hialeah, Florida, United States, 33012
        • Indago Research & Health Center, Inc
      • Jacksonville, Florida, United States, 32204
        • Northeast Research Institute - Downtown Office
      • Kissimmee, Florida, United States, 34741
        • IHS Health Research
      • Lakeland, Florida, United States, 33805
        • Clinical Research of Central Florida
      • Margate, Florida, United States, 33063
        • South Florida Clinical Research Institute
      • Miami, Florida, United States, 33184
        • Felicidad Medical Research
      • Miami Lakes, Florida, United States, 33016-1518
        • Floridian Clinical Research, LLC
      • Orlando, Florida, United States, 32825
        • Florida Institute for Clinical Research, LLC
      • Port Charlotte, Florida, United States, 33952
        • Peace River Cardiovascular Center
      • Saint Augustine, Florida, United States, 32080
        • Northeast Research Institute - St. Augustine
      • St. Petersburg, Florida, United States, 33704
        • IMA Clinical Research St. Petersburg
      • Tampa, Florida, United States, 33606
        • Clinical Research of West Florida
      • West Palm Beach, Florida, United States, 33401
        • Metabolic Research Institute, Inc.
    • Georgia
      • Augusta, Georgia, United States, 30909
        • Masters of Clinical Research
      • Conyers, Georgia, United States, 30094
        • HOPE Clinical Research & Wellness
      • Gainesville, Georgia, United States, 30501
        • Center for Advanced Research & Education
      • Johns Creek, Georgia, United States, 30024
        • Nsc Research
      • Lawrenceville, Georgia, United States, 30046
        • Balanced Life Health Care Solutions/SKYCRNG
      • Sandy Springs, Georgia, United States, 30328
        • WR-Mount Vernon Clinical Research, LLC
      • Union City, Georgia, United States, 30291
        • Rophe Adult and Pediatric Medicine/SKYCRNG
      • Woodstock, Georgia, United States, 30189
        • North Georgia Clinical Research
    • Hawaii
      • Honolulu, Hawaii, United States, 96814
        • East-West Medical Research Institute
    • Idaho
      • Blackfoot, Idaho, United States, 83221
        • Elite Clinical Trials
      • Idaho Falls, Idaho, United States, 83404
        • Rocky Mountain Clinical Research
      • Meridian, Idaho, United States, 83646
        • Solaris Clinical Research
      • Meridian, Idaho, United States, 83642
        • Velocity Clinical Research, Boise
    • Illinois
      • Chicago, Illinois, United States, 60602
        • IMA Clinical Research Chicago
      • Springfield, Illinois, United States, 62711
        • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
      • Tinley Park, Illinois, United States, 60477
        • Healthcare Research Network - Chicago
    • Indiana
      • Avon, Indiana, United States, 46123
        • American Health Network of Indiana, LLC - Avon
      • Evansville, Indiana, United States, 47715
        • Qualmedica Research, LLC
      • Franklin, Indiana, United States, 46131
        • American Health Network of Indiana, LLC - Franklin
      • Greenfield, Indiana, United States, 46140
        • American Health Network of Indiana, LLC - Greenfield
    • Iowa
      • West Des Moines, Iowa, United States, 50266
        • Iowa Diabetes and Endocrinology Research Center
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Cotton O'Neil Mulvane
      • Topeka, Kansas, United States, 66606
        • Cotton O'Neil Diabetes & Endocrinology
    • Kentucky
      • Bowling Green, Kentucky, United States, 42101
        • Qualmedica Research
      • Louisville, Kentucky, United States, 40213
        • L-MARC Research Center
      • Owensboro, Kentucky, United States, 42301
        • Qualmedica Research, LLC
    • Maryland
      • Baltimore, Maryland, United States, 21229
        • Ascension Saint Agnes Heart Care
      • Columbia, Maryland, United States, 21045
        • Centennial Medical Group
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Massachusetts General Hospital
      • Boston, Massachusetts, United States, 02115
        • Brigham and Women's Hospital Diabetes Program
      • Fall River, Massachusetts, United States, 02721
        • NECCR PrimaCare Research
      • Methuen, Massachusetts, United States, 01844
        • ActivMed Practices and Research
    • Michigan
      • Troy, Michigan, United States, 48098
        • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
    • Minnesota
      • Maplewood, Minnesota, United States, 55109
        • M Health Fairview St. John's Hospital
    • Mississippi
      • Diamondhead, Mississippi, United States, 39525
        • The National Diabetes & Obesity Research Institute
      • Fayette, Mississippi, United States, 39069
        • Prime Health and Wellness/SKYCRNG
      • Olive Branch, Mississippi, United States, 38654-3514
        • Olive Branch Family Medical Center
      • Ridgeland, Mississippi, United States, 39157
        • SKY Integrative Medical Center/SKYCRNG
    • Missouri
      • City of Saint Peters, Missouri, United States, 63303
        • StudyMetrix Research
      • Hazelwood, Missouri, United States, 63042
        • Healthcare Research Network - St. Louis
      • Springfield, Missouri, United States, 65807
        • Clinvest Research LLC
      • St Louis, Missouri, United States, 63117
        • IMA Clinical Research - St. Louis
    • Montana
      • Billings, Montana, United States, 59101
        • Billings Clinic
    • Nebraska
      • Omaha, Nebraska, United States, 68105
        • VA Nebraska-Western Iowa Health Care System
    • Nevada
      • Las Vegas, Nevada, United States, 89148
        • Palm Research Center Sunset
      • Las Vegas, Nevada, United States, 89128
        • Palm Research Center Tenaya
      • Las Vegas, Nevada, United States, 89109
        • Excel Clinical Research, LLC
      • Las Vegas, Nevada, United States, 89107
        • DaVita Clinical Research - Las Vegas
      • Reno, Nevada, United States, 89511
        • Advanced Research Institute - Reno
    • New Jersey
      • East Brunswick, New Jersey, United States, 08816
        • UniMed Center
      • Linden, New Jersey, United States, 07036
        • NJ MedCare & NJ Heart
      • Marlton, New Jersey, United States, 08053
        • Hassman Research Institute Marlton Site
      • Warren Township, New Jersey, United States, 07059
        • IMA Clinical Research Warren
    • New Mexico
      • Albuquerque, New Mexico, United States, 87109
        • Ima Clinical Research
    • New York
      • Albany, New York, United States, 12203
        • Albany Medical College, Division of Community Endocrinology
      • Binghamton, New York, United States, 13905
        • Meridian Clinical Research, LLC
      • New York, New York, United States, 10016
        • NYU Langone Health
      • New York, New York, United States, 10036
        • Ima Clinical Research
      • Rochester, New York, United States, 14609
        • Rochester Clinical Research, LLC
      • Vestal, New York, United States, 13850
        • Meridian Clinical Research, LLC
    • North Dakota
      • Fargo, North Dakota, United States, 58104
        • Lillestol Research
    • Ohio
      • Columbus, Ohio, United States, 43213
        • Aventiv Research Inc
    • Oklahoma
      • Norman, Oklahoma, United States, 73069
        • Alliance for Multispecialty Research, LLC
    • Oregon
      • Corvallis, Oregon, United States, 97330
        • The Corvallis Clinic, P.C.
    • Pennsylvania
      • Beaver, Pennsylvania, United States, 15009
        • Heritage Valley Medical Group, Inc.
      • Camp Hill, Pennsylvania, United States, 17011
        • Capital Area Research, LLC
      • Philadelphia, Pennsylvania, United States, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, United States, 19114
        • Tristar Clinical Investigations
      • Pittsburgh, Pennsylvania, United States, 15243
        • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
      • Yardley, Pennsylvania, United States, 19067
        • Cardiology Consultants of Philadelphia Yardley
    • Tennessee
      • Chattanooga, Tennessee, United States, 37421
        • WR-Clinsearch, LLC
    • Texas
      • Austin, Texas, United States, 78749
        • Texas Diabetes & Endocrinology, P.A.
      • Austin, Texas, United States, 78757
        • Pinnacle Clinical Research
      • Dallas, Texas, United States, 75230
        • Dallas Diabetes Research Center
      • Denison, Texas, United States, 75020
        • Soma Clinical Trials
      • El Paso, Texas, United States, 79902
        • Medresearch Inc
      • Fort Worth, Texas, United States, 76132
        • Diabetes and Thyroid Center of Ft. Worth
      • Fort Worth, Texas, United States, 76164
        • Valley Institute of Research - Fort Worth
      • Houston, Texas, United States, 77030
        • Houston Methodist Hospital
      • Houston, Texas, United States, 77043
        • Biopharma Informatic, LLC
      • Houston, Texas, United States, 77084
        • Biopharma Informatic, LLC
      • Houston, Texas, United States, 77057
        • Next Level Urgent Care
      • Houston, Texas, United States, 77025
        • AngioCardiac Care of Texas, PA
      • Houston, Texas, United States, 77089
        • Research Physicians Network, LLC
      • Lewisville, Texas, United States, 75057
        • EPIC Clinical Research
      • Lufkin, Texas, United States, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • McAllen, Texas, United States, 78503
        • Biopharma Informatic, LLC
      • McKinney, Texas, United States, 75071
        • Texas Institute of Cardiology, PA
      • Mesquite, Texas, United States, 75149
        • Southern Endocrinology Associates
      • North Richland Hills, Texas, United States, 76180
        • North Hills Family Medicine/North Hills Medical Research
      • San Antonio, Texas, United States, 78229
        • Clinical Trials of Texas, LLC
      • San Antonio, Texas, United States, 78229
        • Pinnacle Clinical Research
      • San Antonio, Texas, United States, 78230
        • VIP Trials
      • Shavano Park, Texas, United States, 78231
        • Consano Clinical Research, LLC
      • Shenandoah, Texas, United States, 77384
        • DaVita Clinical Research - North Houston
      • Tomball, Texas, United States, 77375
        • Northwest Houston Heart Center
      • Waco, Texas, United States, 76710
        • Impact Research Institute
      • Weslaco, Texas, United States, 78596
        • Texas Valley Clinical Research
      • Wylie, Texas, United States, 75098
        • Soma Clinical Trials
    • Utah
      • Ogden, Utah, United States, 84405
        • Advanced Research Institute
      • Sandy City, Utah, United States, 84070
        • Advanced Research Institute - Sandy
      • West Valley City, Utah, United States, 84120
        • Kalo Clinical Research
    • Virginia
      • Richmond, Virginia, United States, 23294
        • National Clinical Research, Inc
      • Richmond, Virginia, United States, 23219
        • Dominion Medical Associates, Inc.
    • Washington
      • Redmond, Washington, United States, 98052
        • Eastside Research Associates
      • Renton, Washington, United States, 98057
        • Rainier Clinical Research Center
      • Wenatchee, Washington, United States, 98801
        • Central Washington Health Services Association d/b/a Confluence Health
    • West Virginia
      • Morgantown, West Virginia, United States, 26505
        • Ima Clinical Research
    • Wisconsin
      • Green Bay, Wisconsin, United States, 54303
        • St. Vincent Hospital d/b/a Prevea Health

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m ²)

  • Are either

    • individuals ≥40 years of age with established cardiovascular disease (CVD).

      • CVD is defined as meeting at least one of the following:

        • Coronary artery disease
        • Cerebrovascular disease
      • Peripheral arterial disease OR
      • individuals without established CVD but have the presence of cardiovascular (CV) risk factors (primary prevention)

      • women 55-69 years of age or men 50-64 years of age with at least 3 risk factors like tobacco use, dyslipidemia, hypertension at screening, or

        • women ≥70 years of age or men, ≥65 years of age with at least 2 risk factors at screening.

Exclusion Criteria:

  • Have type 1 diabetes (T1D) or (T2D), history of ketoacidosis, or hyperosmolar state/coma
  • Have laboratory evidence diagnostic of diabetes mellitus at screening of HbA1c ≥6.5% (≥48 millimole/mole (mmol/mol) or fasting glucose (FG) ≥126 milligram/deciliter (≥7.0 millimole/liter (mmol/L).

  • Any one of the following CV conditions within 90 days prior to screening

    • MI
    • acute coronary syndrome
    • stroke
    • coronary or peripheral arterial revascularization procedure, which may also include carotid artery revascularization, or
    • acute decompensated heart failure
  • Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction or have undergone or currently planning any gastric bypass (metabolic) surgery or restrictive bariatric surgery. Note: Liposuction or abdominoplasty are not considered as gastric bypass procedures.
  • Have a history of chronic or acute pancreatitis
  • Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
  • Have acute or chronic hepatitis, or clinical signs or symptoms of any other liver disease, or have elevated liver enzyme measurements, determined by the central laboratory at screening
  • Have a presence or history of malignant neoplasms within the past 5 years prior to screening.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Tirzepatide
Participants will receive escalated doses of tirzepatide subcutaneously (SC) up to a maximum tolerated dose.
Drug: Tirzepatide
Administered SC
Other Names:
  • LY3298176
Placebo Comparator: Placebo
Participants will receive tirzepatide matched placebo.
Drug: Placebo
Administered SC

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events)
Time Frame: Up to 5 Years
Time to first occurrence of any component event of composite, all-cause death, nonfatal MI, nonfatal stroke, coronary revascularization, or heart failure events that results in hospitalization or urgent visits.
Up to 5 Years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to Onset of Type 2 Diabetes (T2D)
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence of Any Component Event of Major Adverse Cardiovascular Events-3 (MACE-3) (CV Death, Nonfatal MI or Nonfatal Stroke)
Time Frame: Up to 5 Years
Time to first occurrence of any component event of MACE-3 (CV death, nonfatal MI or nonfatal stroke)
Up to 5 Years
Mean Change from Baseline Short Form-36 Version 2 (SF-36 v2) Acute Form Physical Functioning Domain Score
Time Frame: Baseline, 2 Years
The SF-36 v2 acute, 1-week recall version is a 36-item generic, participant-administered measure designed to assess the following 8 domains (Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role - Emotional, and Mental Health. Each domain is scored individually and further aggregated into 2 health component summary scores, physical component and mental component summary. Scoring of each domain and both summary scores are norm-based and presented in the form of T-scores, with a mean of 50 and standard deviation of 10; higher scores indicate better levels of function and/or better health.
Baseline, 2 Years
Time to the Occurrence of All-cause Death
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence of CV Death
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence of MI
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence of Stroke
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence of Coronary Revascularization
Time Frame: Up to 5 Years
Up to 5 Years
Time to First Occurrence Heart Failure (HF) Events
Time Frame: Up to 5 Years
Time to first occurrence heart failure (HF) events that result in hospitalization or urgent visits
Up to 5 Years
Time to First Occurrence of Hospitalization for Unstable Angina
Time Frame: Up to 5 Years
Up to 5 Years
Time to first occurrence of Hospitalization or Urgent Visit
Time Frame: Up to 5 Years
Time to first occurrence of hospitalization or urgent visit due to atrial fibrillation, or cardioversion or ablation for atrial fibrillation
Up to 5 Years
Time to First Occurrence of Any Component Event of the Composite Endpoint (eGFR, ESRD, or Renal Death)
Time Frame: Up to 5 Years
Time to first occurrence of any component event of the composite endpoint ≥40% sustained decline in eGFR, ESRD, or renal death.
Up to 5 Years
Percent Change from Baseline in Body Weight
Time Frame: Baseline, 156 Weeks
Baseline, 156 Weeks
Change from Baseline in Systolic Blood Pressure (SBP) in Millimeter Mercury (mmHg)
Time Frame: Baseline, 156 Weeks
Baseline, 156 Weeks
Change from Baseline Diastolic Blood Pressure (DBP) (mmHg)
Time Frame: Baseline, 156 Weeks
Baseline, 156 Weeks
Percentage of Participants with Hemoglobin A1c (HbA1c) <39 Millimole/Mole (mmol/mol) (5.7%)
Time Frame: Up to 5 Years
Percentage of participants with HbA1c <39 mmol/mol (5.7%) at each time where HbA1c is assessed for participants with a screening HbA1c ≥39 mmol/mol.
Up to 5 Years
Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)
Time Frame: Up to 5 Years
In participants with high or very high risk chronic kidney disease
Up to 5 Years
Time to First Occurrence of Any Component Event of Composite Endpoint (All-Cause Death, Nonfatal MI, Nonfatal Stroke, Coronary Revascularization, Heart Failure Events, > 40% Sustained Decline in eGFR, or End Stage Renal Disease)
Time Frame: Up to 5 Years
In participants with prediabetes
Up to 5 Years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559 or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern Time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 11, 2022

Primary Completion (Estimated)

October 1, 2027

Study Completion (Estimated)

October 1, 2027

Study Registration Dates

First Submitted

September 22, 2022

First Submitted That Met QC Criteria

September 22, 2022

First Posted (Actual)

September 27, 2022

Study Record Updates

Last Update Posted (Estimated)

January 12, 2026

Last Update Submitted That Met QC Criteria

January 9, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 17253
  • I8F-MC-GPIJ (Other Identifier: Eli Lilly and Company)
  • 2022-501744-15-00 (Other Identifier: EU Clinical Trial Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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