Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)

The primary objective of this trial is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).

Study Overview

• Status: Active, not recruiting
• Conditions: Atherosclerotic Cardiovascular Disease
• Intervention / Treatment: Drug: Placebo; Drug: Olpasiran

• Study Type: Interventional
• Enrollment (Actual): 7297
• Phase: Phase 3

Expanded Access

Available outside the clinical trial. See expanded access record.

Contacts and Locations

Study Locations

• Argentina
  • Buenos Aires, Argentina, C1430EGF
    • Clinica Adventista Belgrano
  • Córdoba, Argentina, X5003DCE
    • Instituto Médico DAMIC
  • Santa Fe, Argentina, S3000FWO
    • Centro de Investigaciones Clínicas del Litoral
  • Buenos Aires
    • Bahía Blanca, Buenos Aires, Argentina, 8000
      • Instituto de Investigaciones Clínicas Bahia Blanca
    • CABA, Buenos Aires, Argentina, C1407GTN
      • Cemedic Centro de Especialidades Medicas
    • CABA, Buenos Aires, Argentina, C1425AGC
      • Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
    • CABA, Buenos Aires, Argentina, C1426ABP
      • Consultorios Medicos Dr Besada
    • CABA, Buenos Aires, Argentina, C1027AAP
      • CINME - Centro de Investigaciones Metabolicas
    • CABA, Buenos Aires, Argentina, C1406BOA
      • Consultorio Medico Dr Litvak Bruno
    • CABA, Buenos Aires, Argentina, 1060
      • CEDIC Centro de Investigación Clínica
    • CABA, Buenos Aires, Argentina, 1061
      • Ciprec Centro de Investigacion y Prevencion Cardiovascular
    • CABA, Buenos Aires, Argentina, C1426ABP
      • Fundacion Respirar - Consultorios Medicos Dr Doreski
    • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1093AAS
      • Fundacion Favaloro
    • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1430
      • Glenny Corp SA
    • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1428ART
      • Icba Instituto Cardiovascular de Buenos Aires
    • Cuidad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1199ABB
      • Hospital Italiano de Buenos Aires
    • Morón, Buenos Aires, Argentina, B1708EPE
      • Ciad - Consultorio Integral de Atencion al Diabetico
    • Quilmes, Buenos Aires, Argentina, B1878GEG
      • Instituto De Investigaciones Clinicas Quilmes
    • San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
      • Instituto de Investigaciones Clinicas de San Nicolas
    • Zárate, Buenos Aires, Argentina, B2800DGH
      • Instituto de Investigaciones Clinicas Zarate
  • Córdoba Province
    • Córdoba, Córdoba Province, Argentina, 5000
      • Clinica Privada del Prado
    • Córdoba, Córdoba Province, Argentina, 5000
      • Instituto Latinoamericano de Investigaciones Medicas Cidim-Ilaim
    • Córdoba, Córdoba Province, Argentina, X5000AAW
      • Instituto de Investigaciones Clinicas de Cordoba
    • Villa María, Córdoba Province, Argentina, 5900
      • Clinica Fusavim Privada SRL
  • Santa Fe Province
    • Rosario, Santa Fe Province, Argentina, 2000
      • Instituto de Investigaciones Clinicas Rosario
• Australia
  • Australian Capital Territory
    • Garran, Australian Capital Territory, Australia, 2605
      • Canberra Hospital
  • New South Wales
    • Camperdown, New South Wales, Australia, 2050
      • Royal Prince Alfred Hospital
    • Concord, New South Wales, Australia, 2139
      • Concord Repatriation General Hospital
    • Liverpool, New South Wales, Australia, 2170
      • Liverpool Hospital
    • Sydney, New South Wales, Australia, 2010
      • Holdsworth House Medical Practice
    • Wollongong, New South Wales, Australia, 2500
      • Wollongong Hospital
  • Queensland
    • Auchenflower, Queensland, Australia, 4066
      • Advara HeartCare Wesley
    • Bundaberg, Queensland, Australia, 4670
      • Advara HeartCare Bundaberg
    • Herston, Queensland, Australia, 4029
      • Royal Brisbane and Womens Hospital
    • Milton, Queensland, Australia, 4064
      • Core Research Group Pty Ltd
    • Woolloongabba, Queensland, Australia, 4102
      • Dr Heart Pty Ltd
  • South Australia
    • Adelaide, South Australia, Australia, 5000
      • Nightingale Research
    • Bedford Park, South Australia, Australia, 5042
      • Flinders Medical Centre
    • Leabrook, South Australia, Australia, 5068
      • Advara HeartCare Leabrook
  • Tasmania
    • Hobart, Tasmania, Australia, 7000
      • Royal Hobart Hospital
  • Victoria
    • Berwick, Victoria, Australia, 3806
      • Advara HeartCare Berwick
    • Clayton, Victoria, Australia, 3168
      • Victorian Heart Hospital
    • Epping, Victoria, Australia, 3076
      • The Cardiologists Proprietary Limited
    • Geelong, Victoria, Australia, 3220
      • Barwon Health Geelong Hospital
    • Ringwood, Victoria, Australia, 3134
      • Advara HeartCare Ringwood
  • Western Australia
    • Joondalup, Western Australia, Australia, 6027
      • Advara HeartCare Joondalup
    • Murdoch, Western Australia, Australia, 6150
      • Mount Hospital
    • Nedlands, Western Australia, Australia, 6009
      • Linear Clinical Research Limited
• Austria
  • Feldkirch, Austria, 6800
    • Landeskrankenhaus Feldkirch
  • Graz, Austria, 8036
    • Medizinische Universitaet Graz
  • Klagenfurt, Austria, 9020
    • Klinikum Klagenfurt am Woerthersee
  • Linz, Austria, 4021
    • Krankenhaus der Barmherzigen Brueder Linz
  • Salzburg, Austria, 5020
    • Landeskrankenhaus Salzburg
  • Sankt Pölten, Austria, 3100
    • Universitaetsklinikum Sankt Poelten
  • Vienna, Austria, 1160
    • Klinik Ottakring
  • Vienna, Austria, 1030
    • Klinik Landstraße
  • Vienna, Austria, 1090
    • Universitaetsklinikum Allgemeines Krankenhaus Wien
  • Vienna, Austria, 1130
    • Klinik Hietzing
  • Vienna, Austria, 1210
    • Krankenhaus Nord - Klinik Floridsdorf
• Belgium
  • Aalst, Belgium, 9300
    • Algemeen Stedelijk Ziekenhuis Aalst
  • Aalst, Belgium, 9300
    • Onze Lieve Vrouw Ziekenhuis - campus Aalst
  • Antwerp, Belgium, 2030
    • Ziekenhuisnetwerk Antwerpen site Cadix
  • Brussels, Belgium, 1070
    • Cliniques universitaires de Bruxelles Hopital Erasme
  • Dendermonde, Belgium, 9200
    • Algemeen Ziekenhuis Sint Blasius
  • Edegem, Belgium, 2650
    • Universitair Ziekenhuis Antwerpen
  • Genk, Belgium, 3600
    • Ziekenhuis Oost-Limburg - Campus Sint-Jan
  • Ghent, Belgium, 9000
    • Algemeen Ziekenhuis Sint Lucas
  • Hasselt, Belgium, 3500
    • Jessa Ziekenhuis - Campus Virga Jesse
  • Leuven, Belgium, 3000
    • Universitair Ziekenhuis Leuven - Campus Gasthuisberg
  • Liège, Belgium, 4000
    • Centre Hospitalier Régional de la Citadelle
  • Mechelen, Belgium, 2800
    • Algemeen Ziekenhuis Sint-Maarten
  • Turnhout, Belgium, 2300
    • Algemeen Ziekenhuis Turnhout
• Brazil
  • Rio de Janeiro, Brazil, 20241-180
    • IBPCLIN Instituto Brasil de Pesquisa Clinica
  • Rio de Janeiro, Brazil, 22240-006
    • Fundacao Pro-Coracao
  • São Paulo, Brazil, 04266-010
    • Centro Paulista de Investigacoes Clinicas Cepic
  • Ceará
    • Fortaleza, Ceará, Brazil, 60430-350
      • Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
    • Fortaleza, Ceará, Brazil, 60430-270
      • Hospital Universitario Walter Cantidio
  • Espírito Santo
    • Vitória, Espírito Santo, Brazil, 29055-450
      • Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
  • Estado de Bahia
    • Salvador, Estado de Bahia, Brazil, 40050-410
      • Hospital Santa Izabel
    • Salvador, Estado de Bahia, Brazil, 40301-155
      • Hospital Ana Nery
    • Salvador, Estado de Bahia, Brazil, 41810-011
      • Instituto de Ensino e Pesquisa do Hospital da Bahia
  • Federal District
    • Brasília, Federal District, Brazil, 71625-175
      • Associacao de Amparo a Saude Ensino e Pesquisa
  • Goiás
    • Goiânia, Goiás, Brazil, 74605-020
      • Hospital das Clinicas da Universidade Federal de Goias
  • Mato Grosso do Sul
    • Campo Grande, Mato Grosso do Sul, Brazil, 79080-190
      • Hospital Universitario Maria Aparecida Pedrossian
  • Minas Gerais
    • Uberlândia, Minas Gerais, Brazil, 38400-500
      • Eurolatino Pesquisas Medicas
  • Paraná
    • Curitiba, Paraná, Brazil, 80730-150
      • Nucleo de Pesquisa Clinica
    • Curitiba, Paraná, Brazil, 80045-170
      • Quanta Diagnostico por Imagem
  • Pernambuco
    • Recife, Pernambuco, Brazil, 52051-380
      • Hospital Agamenon Magalhaes
    • Recife, Pernambuco, Brazil, 50100-060
      • PROCAPE
  • Rio Grande do Norte
    • Natal, Rio Grande do Norte, Brazil, 59020-035
      • Instituto Atena de Pesquisa Clinica
  • Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
      • Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90620-001
      • Instituto de Cardiologia do Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90430-001
      • Nucleo de Pesquisa Clinica do Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
      • Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento
    • Porto Alegre, Rio Grande do Sul, Brazil, 90020-090
      • Hospital Sao Francisco da Santa Casa de Misericordia de Porto Alegre
    • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
      • Hospital das Clinicas de Porto Alegre
    • Porto Alegre, Rio Grande do Sul, Brazil, 90840-440
      • Imv Pesquisa Cardiologica
    • Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
      • FZ Pesquisa e Servicos em Cardiologia LTDA
  • Santa Catarina
    • Blumenau, Santa Catarina, Brazil, 89020-430
      • AngioCor Blumenau
  • Sergipe
    • Aracaju, Sergipe, Brazil, 49055-530
      • jmf Clinica do Coracao ltda
  • São Paulo
    • Campinas, São Paulo, Brazil, 13060-080
      • Instituto de Pesquisa clinica de Campinas
    • Campinas, São Paulo, Brazil, 13092-133
      • Loema Instituto de Pesquisa Clinica e Consultores Ltda
    • Marília, São Paulo, Brazil, 17515-000
      • icm Instituto do Coração de Marilia
    • Ribeirão Preto, São Paulo, Brazil, 14051-140
      • Hospital Das Clinicas Da Faculdade De Medicina De Ribeirao Preto da Universidade de Sao Paulo
    • Ribeirão Preto, São Paulo, Brazil, 14026-900
      • Clinicor Clinica Cardiologica Ltda
    • São José do Rio Preto, São Paulo, Brazil, 15090-000
      • Hospital de Base de Sao Jose do Rio Preto
    • São Paulo, São Paulo, Brazil, 04012-180
      • Instituto Dante Pazzanese de Cardiologia
    • São Paulo, São Paulo, Brazil, 01308-050
      • Sociedade Beneficente de Senhoras Hospital Sirio Libanes
    • São Paulo, São Paulo, Brazil, 01223-001
      • Instituto de Pesquisa em Endocrinologia Clinica IPEC
    • São Paulo, São Paulo, Brazil, 05403-000
      • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
    • Votuporanga, São Paulo, Brazil, 15501-405
      • Integral Pesquisa e Ensino
• Bulgaria
  • Blagoevgrad, Bulgaria, 2700
    • Multiprofile hospital for active treatment Puls AD
  • Haskovo, Bulgaria, 6300
    • Multiprofile Hospital for Active Treatment - Haskovo AD
  • Pleven, Bulgaria, 5800
    • Medical center Medconsult Pleven OOD
  • Pleven, Bulgaria, 5804
    • Multiprofile Hospital for Active Treatment Heart and Brain EAD
  • Sliven, Bulgaria, 8801
    • Medical Center Cardiomed 2020 EOOD
  • Sofia, Bulgaria, 1784
    • Medical Centre Synexus Sofia EOOD
  • Sofia, Bulgaria, 1527
    • University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
  • Sofia, Bulgaria, 1680
    • Medical center Kalimat EOOD
  • Sofia, Bulgaria, 1202
    • Diagnostic-Consultative Center Ascendent OOD
  • Sofia, Bulgaria, 1309
    • Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD
  • Sofia, Bulgaria, 1407
    • Acibadem City Clinic University Multiprofile Hospital For Active Treatment EOOD
  • Stara Zagora, Bulgaria, 6000
    • Medical Center Orpheus OOD
  • Varna, Bulgaria, 9020
    • Ambulatory for Individual Practice for Specialized Medical Care - Kardio EOOD
• Canada
  • British Columbia
    • Vancouver, British Columbia, Canada, V6Z 2C7
      • ARC Biosystems Incorporated
    • Victoria, British Columbia, Canada, V8R 1B2
      • Victoria Heart Institute Foundation
    • Victoria, British Columbia, Canada, V8T 5G4
      • Discovery Clinical Services Ltd
  • Ontario
    • Brampton, Ontario, Canada, L6S 0C6
      • LMC Clinical Research Incorporated
    • Brampton, Ontario, Canada, L6Z 4N5
      • Brampton Clinical Trials
    • Cambridge, Ontario, Canada, N1R 6V6
      • Cambridge Cardiac Care Centre
    • Concord, Ontario, Canada, L4K 4M2
      • LMC Clinical Research Incorporated Thornhill
    • Hamilton, Ontario, Canada, L8L 2X2
      • Hamilton Health Sciences Hamilton General Hospital
    • Mississauga, Ontario, Canada, L4Y 1M3
      • One Heart Care
    • North York, Ontario, Canada, M6B 3H7
      • North York Diagnostic and Cardiac Centre
    • Oakville, Ontario, Canada, L6K 3W7
      • Oakville Cardiovascular Research
    • Toronto, Ontario, Canada, M5S 1B2
      • Womens College Hospital
    • Waterloo, Ontario, Canada, N2T 0C1
      • CPS Research
  • Quebec
    • Chicoutimi, Quebec, Canada, G7H 7K9
      • Ecogene-21 Research
    • Montreal, Quebec, Canada, H4A 3J1
      • Research Institute of McGill University Health Center - Glen Site
    • Montreal, Quebec, Canada, H4A 3J1
      • Institut de recherches cliniques de Montreal
    • Québec, Quebec, Canada, G1V 4G5
      • Institut Universitaire de Cardiologie et de Pneumologie de Quebec
    • Québec, Quebec, Canada, G1R 2J6
      • Centre Hospitalier Universitaire de Quebec, Centre Hotel-Dieu de Quebec
    • Québec, Quebec, Canada, G1V 4M6
      • Clinique des Maladies Lipidiques de Quebec Incorporated
    • Saint-Charles-Borromée, Quebec, Canada, J6E 6J2
      • Centre de sante et de services sociaux du Nord de Lanaudiere
• China
  • Beijing, China, 100050
    • Beijing Friendship Hospital, Capital Medical University
  • Qingdao, China, 266011
    • Qingdao Fuwai Cardiovascular Hospital
  • Shanghai, China, 200080
    • Shanghai General Hospital
  • Shanghai, China, 200080
    • Shanghai Yangpu District Central Hospital（ Yangpu Hospital Affiliated to Tongji University）
  • Wuhan, China, 430060
    • Renmin Hospital of Wuhan University
  • Zhejiang, China, 310007
    • Zhejiang Hospital
  • Beijing Municipality
    • Beijing, Beijing Municipality, China, 100191
      • Peking University Third Hospital
    • Beijing, Beijing Municipality, China, 100730
      • Beijing Hospital
  • Guangdong
    • Guangzhou, Guangdong, China, 510515
      • Nanfang Hospital, Southern Medical University
    • Guangzhou, Guangdong, China, 510120
      • Sun Yat-sen Memorial Hospital Sun Yat-sen University
    • Guangzhou, Guangdong, China, 510080
      • The First Affiliated Hospital ,Sun-Yat Sen University
    • Guangzhou, Guangdong, China, 519041
      • Guangdong Provincial Peoples Hospital
    • Huizhou, Guangdong, China, 516001
      • Huizhou Central Peoples Hospital
  • Guangxi
    • Nanning, Guangxi, China, 530031
      • The Second Nanning Peoples Hospital
    • Nanning, Guangxi, China, 530021
      • The Peoples Hospital of Guangxi Zhuang Autonomous Region
  • Heilongjiang
    • Daqing, Heilongjiang, China, 163000
      • Daqing Oilfield General Hospital
    • Harbin, Heilongjiang, China, 150001
      • The First Affiliated Hospital of Harbin Medical University
  • Henan
    • Nanyang, Henan, China, 473009
      • Nanyang Second General Hospital
  • Hunan
    • Changsha, Hunan, China, 410013
      • The Third Xiangya Hospital of Central South University
    • Changsha, Hunan, China, 410011
      • The Second Xiangya Hospital of Central South University
    • Xiangtan, Hunan, China, 411100
      • Xiangtan Central Hospital
  • Jiangsu
    • Nanjing, Jiangsu, China, 210008
      • Nanjing Drum Tower Hospital
    • Nanjing, Jiangsu, China, 210006
      • Nanjing First Hospital
    • Nanjing, Jiangsu, China, 210009
      • Zhongda Hospital Southeast University
    • Nanjing, Jiangsu, China, 210011
      • The Second Affiliated Hospital of Nanjing Medical University
    • Suzhou, Jiangsu, China, 215006
      • the First Affiliated Hospital of Soochow University
    • Wuxi, Jiangsu, China, 214023
      • Wuxi Peoples Hospital
    • Xuzhou, Jiangsu, China, 221006
      • The Affiliated Hospital of Xuzhou Medical University
  • Jiangxi
    • Nanchang, Jiangxi, China, 330006
      • The Second Affiliated Hospital to Nanchang University
  • Jilin
    • Changchun, Jilin, China, 130021
      • The First Hospital of Jilin University
    • Changchun, Jilin, China, 130033
      • China-Japan Union Hospital of Jilin University
    • Changchun, Jilin, China, 130021
      • Jilin Province Peoples Hospital
  • Liaoning
    • Shenyang, Liaoning, China, 110016
      • The Peoples Hospital of Liaoning Province
  • Ningxia
    • Yinchuan, Ningxia, China, 750004
      • General Hospital of Ningxia Medical University
  • Shaanxi
    • Xi'an, Shaanxi, China, 710068
      • Shaanxi Provincial Peoples Hospital
  • Shandong
    • Jinan, Shandong, China, 250013
      • Jinan Central Hospital
  • Sichuan
    • Chengdu, Sichuan, China, 610041
      • West China Hospital of Sichuan University
  • Tianjin Municipality
    • Tianjin, Tianjin Municipality, China, 300052
      • Tianjin Medical University General Hospital
    • Tianjin, Tianjin Municipality, China, 300222
      • Tianjin Chest Hospital
    • Tianjin, Tianjin Municipality, China, 300120
      • Tianjin Peoples Hospital
  • Xinjiang
    • Ürümqi, Xinjiang, China, 830054
      • The First Affiliated Hospital of Xinjiang Medical University
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310014
      • Zhejiang Provincial Peoples Hospital
    • Wenzhou, Zhejiang, China, 325000
      • The First Affiliated Hospital of Wenzhou Medical University
• Czechia
  • Beroun, Czechia, 266 01
    • Jessenia as, Nemocnice Beroun
  • Brandýs nad Labem, Czechia, 250 01
    • Medicus Services sro
  • Brno, Czechia, 603 00
    • Centrum pro zdravi sro
  • Brno, Czechia, 612 00
    • Kardiologicka ambulance Brno sro
  • Brno, Czechia, 603 00
    • MUDr Karel Kamenik sro
  • Brno, Czechia, 638 00
    • Kardio Elbl sro
  • Brno, Czechia, 602 00
    • MTE Medical Center
  • Bílina, Czechia, 418 01
    • Hornicka nemocnice s poliklinikou spol sro
  • Chomutov, Czechia, 430 02
    • Ordinace pro choroby srdce sro
  • Havirov - Mesto, Czechia, 736 01
    • Dika centrum sro
  • Holešov, Czechia, 769 01
    • Kardio Holesov sro
  • Hradec Králové, Czechia, 500 05
    • Fakultni nemocnice Hradec Kralove
  • Hradec Králové, Czechia, 500 02
    • MUDr Ladislava Harrerova, kardiologicka ordinace
  • Jihlava, Czechia, 586 33
    • Nemocnice Jihlava po
  • Klatovy IV, Czechia, 339 01
    • Kardio Michal Cepelak sro
  • Mladá Boleslav, Czechia, 293 01
    • MUDr Zbynek Kosek, kardiologicka ambulance sro
  • Náchod, Czechia, 547 01
    • Edumed sro
  • Olomouc, Czechia, 779 00
    • PreventaMed sro
  • Ostrava, Czechia, 708 52
    • Fakultni Nemocnice Ostrava
  • Ostrava - Moravska Ostrava, Czechia, 728 80
    • Mestska nemocnice Ostrava, po
  • Ostrava-Dubina, Czechia, 700 30
    • Pedicor Trial sro
  • Pardubice, Czechia, 532 03
    • Nemocnice Pardubickeho kraje as
  • Pilsen, Czechia, 305 99
    • Fakultni Nemocnice Plzen
  • Polička, Czechia, 572 01
    • Policska nemocnice sro
  • Prague, Czechia, 128 08
    • Vseobecna fakultni nemocnice v Praze
  • Prague, Czechia, 140 21
    • Institut Klinicke a Experimentalni Mediciny
  • Prague, Czechia, 198 00
    • Endokrinologie Cerny Most sro
  • Prague, Czechia, 149 00
    • Milan Kvapil sro
  • Prague, Czechia, 101 00
    • Ordinace pro choroby srdce a cev
  • Prague, Czechia, 158 00
    • Interni a kardiologicka ordinace
  • Praha 5 - Smichov, Czechia, 150 00
    • Kardiologicke centrum MUDr Janky Skrobakove sro
  • Pribram VIII, Czechia, 261 01
    • Poliklinika Ravak Pribram
  • Přerov, Czechia, 750 02
    • Kardio Vaclavik sro, Interni a kardiologicka ambulance
  • Trutnov, Czechia, 541 01
    • Kardiologicka ambulance MUDr Ferkl, sro
  • Uherské Hradiště, Czechia, 686 01
    • Clinical Trials Service sro
  • Zlín, Czechia, 760 01
    • Cardio Research sro
  • Zlín, Czechia, 762 75
    • Krajska nemocnice T Bati as
  • České Budějovice, Czechia, 370 01
    • Nemocnice Ceske Budejovice as
• Denmark
  • Aalborg, Denmark, 9000
    • Aalborg Universitetshospital
  • Aarhus N, Denmark, 8200
    • Aarhus Universitetshospital
  • Copenhagen O, Denmark, 2100
    • Rigshospitalet
  • Esbjerg, Denmark, 6700
    • Sydvestjysk Sygehus
  • Gandrup, Denmark, 9000
    • Sanos Gandrup
  • Herlev, Denmark, 2730
    • Herlev Gentofte Hospital
  • Herlev, Denmark, 2730
    • Sanos Clinic
  • Herning, Denmark, 7400
    • Regionshospitalet Gødstrup
  • Holbæk, Denmark, 4300
    • Holbaek Sygehus
  • København NV, Denmark, 2400
    • University of Fredriksberg Hospital
  • København S, Denmark, 2300
    • Amager Hospital
  • Roskilde, Denmark, 4000
    • Sjaellands Universitetshospital, Roskilde
  • Slagelse, Denmark, 4200
    • Slagelse Sygehus
  • Svendborg, Denmark, 5700
    • Svendborg Sygehus
  • Vejle, Denmark, 7100
    • Sanos Vejle
  • Viborg, Denmark, 8800
    • Regionshospitalet Viborg
• Estonia
  • Tallinn, Estonia, 13419
    • North Estonia Medical Centre Foundation
  • Tallinn, Estonia, 10128
    • Center for Clinical and Basic Research Tallinn
  • Tallinn, Estonia, 10117
    • Innomedica
  • Tartu, Estonia, 50406
    • Tartu University Hospital
• Finland
  • Helsinki, Finland, 00029
    • Helsinki University Central Hospital
  • Kuopio, Finland, 70100
    • Satucon Oy/Kuopion tyoterveys
  • Oulu, Finland, 90029
    • Oulu University Hospital
  • Tampere, Finland, 33520
    • Tampere University Hospital
  • Turku, Finland, 20100
    • Suomen Terveystalo Oy
• France
  • Besançon, France, 25030
    • Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz
  • Bron, France, 69677
    • Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel
  • Chambray-lès-Tours, France, 37170
    • Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
  • Compiègne, France, 60200
    • Centre Hospitalier Compiègne-Noyon
  • Dijon, France, 21079
    • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
  • Lille, France, 59037
    • Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez
  • Marseille, France, 13005
    • Hôpital de la Conception
  • Marseille, France, 13285
    • Hôpital Saint-Joseph
  • Montpellier, France, 34090
    • Centre Hospitalier Universitaire de Montpellier - Hopital Lapeyronie
  • Nantes, France, 44800
    • Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec
  • Nice, France, 06000
    • Centre Hospitalier Universitaire de Nice - Hopital Pasteur
  • Paris, France, 75012
    • Hôpital Saint Antoine
  • Paris, France, 75877
    • Hopital Bichat Claude Bernard
  • Paris, France, 75651
    • Hopital Pitie-Salpetriere
  • Reims, France, 51100
    • Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré
  • Rennes, France, 35033
    • Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
  • Strasbourg, France, 67098
    • Centre Hospitalier Universitaire de Strasbourg - Hopital de Hautepierre
  • Toulouse, France, 31059
    • Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
  • Valenciennes, France, 59300
    • Polyclinique Vauban
• Germany
  • Aachen, Germany, 52074
    • Universitaetsklinikum Aachen
  • Bad Krozingen, Germany, 79189
    • Universitaets-Herzzentrum Freiburg - Bad Krozingen
  • Bad Oeynhausen, Germany, 32545
    • Universitaetsklinikum der Ruhr-Universitaet Bochum
  • Berlin, Germany, 13353
    • Charite - Universitaetsmedizin Berlin, Campus Virchow
  • Berlin, Germany, 10787
    • Velocity Clinical Research GmbH
  • Berlin, Germany, 12203
    • Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
  • Bremen, Germany, 28277
    • Klinikum Links der Weser
  • Cologne, Germany, 50937
    • Universitaetsklinikum Koeln
  • Dresden, Germany, 01307
    • Universitaetsklinikum Dresden
  • Essen, Germany, 45147
    • Universitaetsklinikum Essen
  • Frankfurt am Main, Germany, 60590
    • Universitaetsklinikum Frankfurt
  • Frankfurt am Main, Germany, 60596
    • ClinPhenomics CVC GmbH
  • Göttingen, Germany, 37075
    • Evangelisches Krankenhaus Goettingen-Weende
  • Göttingen, Germany, 37099
    • Universitaetsmedizin Goettingen - Georg-August-Universitaet
  • Hamburg, Germany, 20251
    • Universitaetsklinikum Hamburg-Eppendorf
  • Hamburg, Germany, 22041
    • Cardiologicum Hamburg GbR
  • Heidelberg, Germany, 69120
    • Universitaetsklinikum Heidelberg
  • Kassel, Germany, 34121
    • B Braun Ambulantes Herzzentrum Kassel mvz GmbH
  • Leipzig, Germany, 04103
    • Universitaetsklinikum Leipzig
  • Magdeburg, Germany, 39120
    • Otto von Guericke Universitaet Magdeburg
  • Mannheim, Germany, 68167
    • Universitaetsklinikum Mannheim
  • Markkleeberg, Germany, 04416
    • Kardiologische Praxis Doktor Jens Taggeselle
  • München, Germany, 80636
    • Klinikum rechts der Isar der TUM
  • Münster, Germany, 48149
    • Universitaetsklinikum Muenster
  • Papenburg, Germany, 26871
    • Kardiologische Gemeinschaftspraxis Papenburg
  • Remscheid, Germany, 42859
    • Sana-Klinikum Remscheid GmbH
  • Rostock, Germany, 18057
    • Lipidambulanz der Universitaet Rostock
  • Rüdersdorf, Germany, 15562
    • Klinik am See - Ruedersdorf
  • Singen, Germany, 78224
    • Hegau-Bodensee-Klinikum Singen
  • Witten, Germany, 58455
    • Forschungszentrum Ruhr
• Greece
  • Athens, Greece, 18547
    • Metropolitan Hospital
  • Athens, Greece, 15123
    • Hygeia Hospital
  • Athens, Greece, 11528
    • Alexandra Hospital
  • Athens, Greece, 11527
    • Laiko General Hospital
  • Athens, Greece, 10676
    • General Hospital of Athens Evaggelismos
  • Athens, Greece, 11521
    • Athens Naval Hospital
  • Athens, Greece, 11527
    • General Hospital of Athens Ippokrateio
  • Athens, Greece, 14233
    • Konstantopoulio - Agia Olga Hospital of Nea Ionia
  • Athens, Greece, 12462
    • Attikon Hospital
  • Heraklion, Greece, 71500
    • University Hospital of Heraklion
  • Ioannina, Greece, 45500
    • University Hospital Of Ioannina
  • Mytilene, Greece, 81132
    • General Hospital of Mitilini Vostanio
  • Thessaloniki, Greece, 54636
    • General Hospital of Thessaloniki Ahepa
• Hong Kong
  • Hong Kong, Hong Kong
    • University of Hong Kong, Queen Mary Hospital
  • Shatin, New Territories, Hong Kong
    • Prince of Wales Hospital
• Hungary
  • Baja, Hungary, 6500
    • Lausmed Kft
  • Budapest, Hungary, 1021
    • Budapesti Szent Ferenc Korhaz
  • Budapest, Hungary, 1096
    • Gottsegen György Országos Kardiovaszkuláris Intézet
  • Budapest, Hungary, 1033
    • Clinexpert Kft
  • Budapest, Hungary, 1122
    • Semmelweis Egyetem Varosmajori Sziv es Ergyogyaszati Klinika
  • Budapest, Hungary, 1134
    • Eszak-Pesti Centrum Korhaz - Honvedkorhaz
  • Budapest, Hungary, 1027
    • High Tech Medical Kft
  • Békéscsaba, Hungary, 5600
    • Dr Lakatos Ferenc Private Cardiology Practice
  • Debrecen, Hungary, 4032
    • Debreceni Egyetem Klinikai Kozpont
  • Gyöngyös, Hungary, 3200
    • Pharma4 Trial Kft
  • Hatvan, Hungary, 3000
    • BKS Research Kft
  • Komárom, Hungary, 2921
    • Selye János Kórház
  • Miskolc, Hungary, 3526
    • Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
  • Orosháza, Hungary, 5900
    • Dr Nagy Laszlo Kardiologiai maganrendeles es SMO
  • Székesfehérvár, Hungary, 8000
    • Vita Verum Medical Bt
  • Zalaegerszeg, Hungary, 8900
    • Belvarosi Egeszseghaz Kft
  • Zalaegerszeg, Hungary, 8900
    • Obudai Egeszsegugyi Centrum Kft
• Iceland
  • Kopavogur, Iceland, 201
    • Thjonustumidstod Rannsoknaverkefna
  • Kopavogur, Iceland, 201
    • Hjartamidstodin
• Italy
  • Arzignano, Italy, 36071
    • Ospedali dell Ovest Vicentino
  • Bologna, Italy, 40138
    • IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola
  • Brescia, Italy, 25123
    • Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
  • Caserta, Italy, 81100
    • Azienda Ospedaliera Sant Anna e San Sebastiano
  • Catania, Italy, 95126
    • Azienda Ospedaliera Cannizzaro
  • Catanzaro, Italy, 88100
    • Azienda Ospedaliera Universitaria Renato Dulbecco
  • Cona FE, Italy, 44124
    • Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna
  • Florence, Italy, 50139
    • Azienda Ospedaliero Universitaria Careggi
  • Genova, Italy, 16132
    • Ospedale Policlinico San Martino IRCCS
  • Milan, Italy, 20162
    • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
  • Milan, Italy, 20138
    • IRCCS Centro Cardiologico Monzino
  • Napoli, Italy, 80131
    • Azienda Ospedaliera Universitaria Federico II
  • Palermo, Italy, 90127
    • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
  • Rivoli, Italy, 10098
    • Ospedale degli Infermi di Rivoli
  • Roma, Italy, 00133
    • Fondazione Policlinico Tor Vergata
  • Roma, Italy, 00161
    • Azienda Ospedaliera Policlinico Umberto I
  • Rozzano MI, Italy, 20089
    • IRCCS Istituto Clinico Humanitas
  • Salerno, Italy, 84131
    • Azienda Ospedaliera Universitaria Ospedale San Giovanni di Dio e Ruggi D Aragona
  • Sesto San Giovanni (MI), Italy, 20099
    • Multimedica
  • Torino, Italy, 10128
    • Azienda Ospedaliera Ordine Mauriziano di Torino
• Japan
  • Aichi-ken
    • Kasugai-shi, Aichi-ken, Japan, 486-8510
      • Kasugai Municipal Hospital
    • Nagoya, Aichi-ken, Japan, 466-8560
      • Nagoya University Hospital
    • Seto-shi, Aichi-ken, Japan, 489-8642
      • Tosei General Hospital
    • Toyoake-shi, Aichi-ken, Japan, 470-1192
      • Fujita Health University Hospital
  • Aomori
    • Hirosaki-shi, Aomori, Japan, 036-8563
      • Hirosaki University Hospital
  • Chiba
    • Asahi-shi, Chiba, Japan, 289-2511
      • Asahi General Hospital
    • Matsudo-shi, Chiba, Japan, 271-0077
      • New Tokyo Heart Clinic
  • Fukui
    • Yoshida-gun, Fukui, Japan, 910-1193
      • University of Fukui Hospital
  • Fukuoka
    • Fukuoka, Fukuoka, Japan, 814-0180
      • Fukuoka University Hospital
    • Kitakyushu-shi, Fukuoka, Japan, 802-8555
      • Kokura Memorial Hospital
    • Kitakyushu-shi, Fukuoka, Japan, 806-8501
      • Japan Community Health Care Organization Kyushu Hospital
  • Gifu
    • Gifu, Gifu, Japan, 500-8384
      • Gifu Heart Center
    • Ogaki-shi, Gifu, Japan, 503-8502
      • Ogaki Municipal Hospital
  • Hiroshima
    • Hiroshima, Hiroshima, Japan, 730-8518
      • Hiroshima City Hiroshima Citizens Hospital
  • Hokkaido
    • Asahikawa-shi, Hokkaido, Japan, 070-8610
      • Asahikawa City Hospital
    • Hakodate-shi, Hokkaido, Japan, 041-8680
      • Hakodate Municipal Hospital
    • Tomakomai-shi, Hokkaido, Japan, 053-8567
      • Tomakomai City Hospital
  • Hyōgo
    • Himeji-shi, Hyōgo, Japan, 670-8560
      • Hyogo Prefectural Harima-Himeji General Medical Center
    • Kobe, Hyōgo, Japan, 650-0047
      • Kobe City Medical Center General Hospital
  • Ishikawa-ken
    • Kahoku-gun, Ishikawa-ken, Japan, 920-0293
      • Kanazawa Medical University Hospital
    • Kanazawa, Ishikawa-ken, Japan, 920-8641
      • Kanazawa University Hospital
  • Iwate
    • Morioka, Iwate, Japan, 020-0066
      • Iwate Prefectural Central Hospital
  • Kagawa-ken
    • Takamatsu, Kagawa-ken, Japan, 760-8557
      • Kagawa Prefectural Central Hospital
    • Takamatsu, Kagawa-ken, Japan, 760-0017
      • Takamatsu Red Cross Hospital
  • Kagoshima-ken
    • Kagoshima, Kagoshima-ken, Japan, 890-8760
      • Kagoshima City Hospital
    • Kagoshima, Kagoshima-ken, Japan, 892-0822
      • Tenyoukai Chuo Clinic
  • Kanagawa
    • Fujisawa-shi, Kanagawa, Japan, 251-8550
      • Fujisawa City Hospital
    • Isehara-shi, Kanagawa, Japan, 259-1193
      • Tokai University Hospital
    • Sagamihara-shi, Kanagawa, Japan, 252-0375
      • Kitasato University Hospital
    • Yokohama, Kanagawa, Japan, 232-0024
      • Yokohama City University Medical Center
    • Yokohama, Kanagawa, Japan, 227-8501
      • Showa University Fujigaoka Hospital
    • Yokohama, Kanagawa, Japan, 236-0037
      • Yokohama Minami Kyousai Hospital
    • Yokohama, Kanagawa, Japan, 247-8581
      • Yokohama Sakae Kyosai Hospital Federation of National Public Service Personnel Mutual Association
  • Kochi
    • Kochi, Kochi, Japan, 780-8522
      • Chikamori Hospital
  • Kumamoto
    • Kumamoto, Kumamoto, Japan, 860-8556
      • Kumamoto University Hospital
    • Kumamoto, Kumamoto, Japan, 861-4193
      • Saiseikai Kumamoto Hospital
  • Miyagi
    • Sendai, Miyagi, Japan, 980-8574
      • Tohoku University Hospital
    • Sendai, Miyagi, Japan, 981-3133
      • Sendai Cardiovascular Center
  • Miyazaki
    • Miyazaki, Miyazaki, Japan, 880-2102
      • Miyazaki Medical Association Hospital
  • Nagano
    • Matsumoto-shi, Nagano, Japan, 390-8621
      • Shinshu University Hospital
  • Niigata
    • Niigata, Niigata, Japan, 951-8520
      • Niigata University Medical and Dental Hospital
  • Okayama-ken
    • Kurashiki-shi, Okayama-ken, Japan, 701-0192
      • Kawasaki Medical School Hospital
  • Osaka
    • Izumisano, Osaka, Japan, 598-8577
      • Rinku General Medical Center
    • Osaka, Osaka, Japan, 534-0021
      • Osaka City General Hospital
    • Osaka, Osaka, Japan, 558-8558
      • Osaka General Medical Center
    • Osaka, Osaka, Japan, 545-8586
      • Osaka Metropolitan university Hospital
    • Osaka, Osaka, Japan, 530-0005
      • Sakurabashi Watanabe Advanced Healthcare Hospital
    • Osaka, Osaka, Japan, 543-0035
      • Osaka Police Hospital
    • Suita-shi, Osaka, Japan, 565-0871
      • Osaka University Hospital
  • Saga-ken
    • Saga, Saga-ken, Japan, 840-8571
      • Saga-Ken Medical Centre Koseikan
  • Saitama
    • Ageo-shi, Saitama, Japan, 362-8588
      • Ageo Central General Hospital
    • Saitama-shi, Saitama, Japan, 338-0837
      • Sanai Hospital
  • Shizuoka
    • Sunto-gun, Shizuoka, Japan, 411-8611
      • National Hospital Organization Shizuoka Medical Center
  • Tokyo
    • Bunkyo-ku, Tokyo, Japan, 113-8431
      • Juntendo University Hospital
    • Chuo-ku, Tokyo, Japan, 103-0027
      • Tokyo-Eki Center-building Clinic
    • Hachioji-shi, Tokyo, Japan, 192-0918
      • Minamino Cardiovascular Hospital
    • Meguro-ku, Tokyo, Japan, 152-8902
      • National Hospital Organization Tokyo Medical Center
    • Musashino-shi, Tokyo, Japan, 180-8610
      • Japanese Red Cross Musashino Hospital
    • Ome-shi, Tokyo, Japan, 198-0042
      • Ome Medical Center
    • Shinagawa-ku, Tokyo, Japan, 142-8666
      • Showa University Hospital
    • Shinjuku-ku, Tokyo, Japan, 162-8666
      • Tokyo Womens Medical University Hospital
  • Toyama
    • Toyama, Toyama, Japan, 930-8550
      • Toyama Prefectural Central Hospital
  • Wakayama
    • Wakayama, Wakayama, Japan, 649-6335
      • Seiyu Memorial Hospital
  • Yamaguchi
    • Shunan-shi, Yamaguchi, Japan, 745-8522
      • Tokuyama Central Hospital
  • Yamanashi
    • Chuo-shi, Yamanashi, Japan, 409-3898
      • University of Yamanashi Hospital
• Lithuania
  • Alytus, Lithuania, 63200
    • Klinikiniai sprendimai
  • Kaunas, Lithuania, 49449
    • Saules Seimos Medicinos Centras
  • Kaunas, Lithuania, 49387
    • Klinikiniai sprendimai
  • Klaipėda, Lithuania, 91131
    • Kardiologijos ir reabilitacijos klinika
  • Vilnius, Lithuania, 08861
    • Vilnius University Hospital Santaros Clinic Public Institution
  • Šiauliai, Lithuania, 76206
    • Pirmoji viltis JSC
• Mexico
  • Aguascalientes, Mexico, 20230
    • Hospital Cardiologica Aguascalientes
  • Aguascalientes, Mexico, 20230
    • Centro de investigacion Cardiometabolica
  • Aguascalientes, Mexico, 20230
    • Fundacion Cardiovascular de Aguascalientes AC
  • Chihuahua City, Mexico, 31207
    • SCIENTIA Investigacion Clinica SC
  • Mexico City, Mexico, 64060
    • Procliniq Investigacion Clinica
  • Jalisco
    • Guadalajara, Jalisco, Mexico, 44670
      • Virgen Cardiovascular Research SC
  • Nuevo León
    • Monterrey, Nuevo León, Mexico, 64718
      • Eukarya PharmaSite
  • Sinaloa
    • Culiacán, Sinaloa, Mexico, 80230
      • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
  • Veracruz
    • Xalapa, Veracruz, Mexico, 91193
      • Consultorio de Medicina Especializada del Sector Privado
• Netherlands
  • Amersfoort, Netherlands, 3813 TZ
    • Meander Medisch Centrum
  • Amsterdam, Netherlands, 1105 AZ
    • Academisch Medisch Centrum
  • Amsterdam, Netherlands, 1091 AC
    • Onze Lieve Vrouwe Gasthuis
  • Apeldoorn, Netherlands, 7334 DZ
    • Gelre Ziekenhuizen
  • Arnhem, Netherlands, 6815 AD
    • Rijnstate Ziekenhuis
  • Bergen op Zoom, Netherlands, 4624 VT
    • Bravis Ziekenhuis, locatie Roosendaal
  • Breda, Netherlands, 4818 CK
    • Amphia Ziekenhuis
  • Delft, Netherlands, 2625 AD
    • Reinier de Graaf Gasthuis
  • Deventer, Netherlands, 7416 SE
    • Deventer Ziekenhuis
  • Eindhoven, Netherlands, 5623 EJ
    • Catharina Ziekenhuis
  • Eindhoven, Netherlands, 5631 BM
    • Maxima Medisch Centrum
  • Enschede, Netherlands, 7512 KZ
    • Medisch Spectrum Twente
  • Goes, Netherlands, 4462 RA
    • Admiraal de Ruyter Ziekenhuis
  • Gouda, Netherlands, 2803 HH
    • Groene Hart ziekenhuis
  • Groningen, Netherlands, 9728 NT
    • Martini Ziekenhuis
  • Heerlen, Netherlands, 6419 PC
    • Zuyderland Medisch Centrum
  • Hoofddorp, Netherlands, 2134 TM
    • Spaarne Gasthuis, locatie Haarlem Zuid
  • Hoorn, Netherlands, 1624 NP
    • Dijklander Ziekenhuis Hoorn
  • Leiden, Netherlands, 2333 ZA
    • Leids Universitair Medisch Centrum
  • Leiderdorp, Netherlands, 2353 GA
    • Alrijne Ziekenhuis
  • Nijmegen, Netherlands, 6525 GA
    • Radboud Universitair Medisch Centrum
  • Rotterdam, Netherlands, 3015 CE
    • Erasmus Medisch Centrum
  • Sneek, Netherlands, 8601 ZR
    • D and A Research and Genetics
  • The Hague, Netherlands, 2545 AA
    • Haga ziekenhuis
  • The Hague, Netherlands, 2512 VA
    • Haaglanden MC
  • Tiel, Netherlands, 4002 WP
    • Ziekenhuis Rivierenland
  • Tilburg, Netherlands, 5042 AD
    • Elisabeth-TweeSteden Ziekenhuis
  • Utrecht, Netherlands, 3584 CX
    • Universitair Medisch Centrum Utrecht
  • Venlo, Netherlands, 5912 BL
    • VieCuri Medisch Centrum
• Norway
  • Oslo, Norway, 0424
    • Oslo Universitetssykehus HF Aker sykehus
  • Oslo, Norway, 0586
    • Oslo Universitetssykehus HF, Aker sykehus
  • Skedsmokorset, Norway, 2020
    • Skedsmo Medisinske Senter
• Poland
  • Bełchatów, Poland, 97-400
    • American Heart of Poland Spolka Akcyjna
  • Bielsko-Biala, Poland, 43-316
    • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  • Chrzanów, Poland, 32-500
    • American Heart of Poland Spolka Akcyjna
  • Dąbrowa Górnicza, Poland, 41-300
    • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  • Gdansk, Poland, 80-214
    • Uniwersyteckie Centrum Kliniczne
  • Giżycko, Poland, 11-500
    • NZOZ Medica Jerzy Cygler
  • Krakow, Poland, 31-801
    • Jaroslaw Ciosek Rajtar-Medica Centrum Medyczne
  • Kędzierzyn-Koźle, Poland, 47-200
    • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  • Lodz, Poland, 91-347
    • Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi
  • Lubin, Poland, 59-301
    • Miedziowe Centrum Zdrowia SA
  • Lublin, Poland, 20-078
    • Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
  • Lublin, Poland, 20-044
    • CenterMed Spzoo Centermed Lublin
  • Lublin, Poland, 20-857
    • NZOZ Twoja Przychodnia Spzoo Twoja Przychodnia Spzoo
  • Poznan, Poland, 60-354
    • Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Spolka z ograniczona odpowiedzialnos
  • Puławy, Poland, 24-100
    • KO-MED Centra Kliniczne Sp zoo KO-MED Centra Kliniczne Pulawy
  • Sztum, Poland, 82-400
    • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  • Tychy, Poland, 43-100
    • American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  • Warsaw, Poland, 00-215
    • FutureMeds Warszawa Centrum
  • Warsaw, Poland, 04-073
    • Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
  • Warsaw, Poland, 04-628
    • Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy
  • Wroclaw, Poland, 53-673
    • Futuremeds spolka z ograniczona odpowiedzialnoscia
  • Zabrze, Poland, 41-800
    • Slaskie Centrum Chorob Serca W Zabrzu
  • Zamość, Poland, 22-400
    • KO-MED Centra Kliniczne Zamosc
  • Zgierz, Poland, 95-100
    • American Heart of Poland Spolka Akcyjna
• Portugal
  • Almada, Portugal, 2801-951
    • Unidade de Saude Local de Almada-Seixal, EPE - Hospital Garcia de Orta
  • Amadora, Portugal, 2720-276
    • Unidade Local de Saude de Amadora-Sintra, EPE
  • Aveiro, Portugal, 3814-501
    • Unidade Local de Saude da Regiao de Aveiro, EPE - Hospital Infante Dom Pedro
  • Braga, Portugal, 4710-243
    • Unidade Local de Saude de Braga, EPE
  • Carnaxide, Portugal, 2790-134
    • Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital de Santa Cruz
  • Cascais, Portugal, 2755-009
    • Hospital de Cascais
  • Coimbra, Portugal, 3000-075
    • Unidade Local de Saude de Coimbra, EPE
  • Guimarães, Portugal, 4835-044
    • Unidade Local de Saude do Alto Ave, EPE
  • Matosinhos Municipality, Portugal, 4464-513
    • Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
  • Porto, Portugal, 4099-001
    • Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio
  • Santa Maria da Feira, Portugal, 4520-211
    • Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao
  • Setúbal, Portugal, 2910-446
    • Unidade Local de Saude da Arrabida, EPE - Hospital de Sao Bernardo
  • Vila Nova de Gaia, Portugal, 4430-502
    • Unidade Local de Saude de Gaia-Espinho, EPE
• Romania
  • Baia Mare, Romania, 430123
    • cmi Cardiologie - Dr Mercea Corina Delia
  • Bucharest, Romania, 050098
    • Spitalul Universitar de Urgență București
  • Bucharest, Romania, 011461
    • Spitalul Clinic Universitar de Urgenta Elias
  • Buzău, Romania, 120133
    • Matcord Biomedica Buzau
  • Piteşti, Romania, 110438
    • Sc Sal Med Srl
  • Timișoara, Romania, 300079
    • Spitalul Clinic Municipal de Urgenta Timisoara
  • Târgu Mureş, Romania, 540136
    • Spitalul Clinic Judetean de Urgenta Targu Mures
  • Târgu Mureş, Romania, 540124
    • Cardio Med Medical Center Targu Mures
• Slovakia
  • Bardejov, Slovakia, 085 01
    • Alian, sro
  • Bratislava, Slovakia, 833 48
    • Narodny ustav srdcovych a cievnych chorob, as
  • Bratislava, Slovakia, 841 04
    • Kardiovita sro
  • Brezno, Slovakia, 977 01
    • Nemocnica s poliklinikou Brezno, no
  • Kláštor pod Znievom, Slovakia, 038 43
    • Intergal, sro
  • Košice, Slovakia, 040 01
    • Medical group Kosice sro
  • Košice, Slovakia, 040 22
    • Cardio D and R, sro Kosice
  • Košice, Slovakia, 040 01
    • Zarmed, sro
  • Lučenec, Slovakia, 984 01
    • Kardio 1 sro
  • Moldava nad Bodvou, Slovakia, 045 01
    • Medi M and M sro
  • Nitra, Slovakia, 949 01
    • Kardiocentrum Nitra sro
  • Nové Zámky, Slovakia, 940 01
    • Kardiomed NZ, sro
  • Námestovo, Slovakia, 029 01
    • Oralek, sro
  • Prešov, Slovakia, 080 01
    • Medikard, sro
  • Prešov, Slovakia, 080 01
    • Medispol, sro
  • Rimavská Sobota, Slovakia, 979 01
    • Medilex sro
  • Rožňava, Slovakia, 048 01
    • Tatratrial sro
  • Svidník, Slovakia, 089 01
    • Interna SK, sro
  • Trebišov, Slovakia, 075 01
    • Areteus sro
  • Trenčín, Slovakia, 911 01
    • CardiOr, sro
• South Korea
  • Busan, South Korea, 49201
    • Dong-A University Hospital
  • Gwangju, South Korea, 61469
    • Chonnam National University Hospital
  • Incheon, South Korea, 21565
    • Gachon University Gil Medical Center
  • Seongnam-si, Gyeonggi-do, South Korea, 13620
    • Seoul National University Bundang Hospital
  • Seoul, South Korea, 03080
    • Seoul National University Hospital
  • Seoul, South Korea, 05505
    • Asan Medical Center
  • Seoul, South Korea, 06351
    • Samsung Medical Center
  • Seoul, South Korea, 03181
    • Kangbuk Samsung Hospital
  • Seoul, South Korea, 03722
    • Severance Hospital, Yonsei University Health System
  • Seoul, South Korea, 06591
    • The Catholic University of Korea Seoul St Marys Hospital
  • Seoul, South Korea, 02841
    • Korea University Anam Hospital
  • Seoul, South Korea, 08308
    • Korea University Guro Hospital
  • Ulsan, South Korea, 44033
    • Ulsan University Hospital
  • Wonju-si, Gangwon-do, South Korea, 26426
    • Yonsei University Wonju Severance Christian Hospital
• Spain
  • Madrid, Spain, 28034
    • Hospital Universitario Ramon y Cajal
  • Madrid, Spain, 28040
    • Hospital Clinico San Carlos
  • Madrid, Spain, 28041
    • Hospital Universitario 12 de Octubre
  • Andalusia
    • Córdoba, Andalusia, Spain, 14004
      • Hospital Universitario Reina Sofia
    • Málaga, Andalusia, Spain, 29010
      • Hospital Clinico Universitario Virgen de la Victoria
    • Seville, Andalusia, Spain, 41009
      • Hospital Universitario Virgen Macarena
    • Seville, Andalusia, Spain, 41013
      • Hospital Universitario Virgen del Rocio
  • Aragon
    • Zaragoza, Aragon, Spain, 50009
      • Hospital Universitario Miguel Servet
  • Castille and León
    • León, Castille and León, Spain, 24071
      • Hospital Universitario de Leon
  • Catalonia
    • Badalona, Catalonia, Spain, 08916
      • Hospital Universitari Germans Trias i Pujol
    • Barcelona, Catalonia, Spain, 08025
      • Hospital De La Santa Creu I Sant Pau
    • Barcelona, Catalonia, Spain, 08003
      • Hospital del Mar
    • Barcelona, Catalonia, Spain, 08036
      • Hospital Clínic i Provincial de Barcelona
    • Barcelona, Catalonia, Spain, 08035
      • Hospital Universitari Vall d Hebron
    • L'Hospitalet de Llobregat, Catalonia, Spain, 08907
      • Hospital Universitari de Bellvitge
    • Sant Joan Despí, Catalonia, Spain, 08970
      • Hospital de Sant Joan Despi Moises Broggi
  • Galicia
    • A Coruña, Galicia, Spain, 15006
      • Complexo Hospitalario Universitario A Coruña
    • Vigo, Galicia, Spain, 36312
      • Hospital Álvaro Cunqueiro
  • Murcia
    • El Palmar, Murcia, Spain, 30120
      • Hospital Universitario Virgen de la Arrixaca
  • Principality of Asturias
    • Gijón, Principality of Asturias, Spain, 33394
      • Hospital de Cabueñes
  • Valencia
    • Valencia, Valencia, Spain, 46010
      • Hospital Clinico Universitario de Valencia
    • Valencia, Valencia, Spain, 46015
      • Hospital Arnau de Vilanova de Valencia
• Sweden
  • Falun, Sweden, 791 82
    • Falu Lasarett
  • Gothenburg, Sweden, 413 45
    • Sahlgrenska Universitetssjukhuset
  • Helsingborg, Sweden, 252 21
    • Helsingborgs Lasarett
  • Lund, Sweden, 222 21
    • Clemenstorgets Hjartmottagning
  • Malmo, Sweden, 211 52
    • Pharmasite Malmo
  • Stockholm, Sweden, 141 86
    • Karolinska Universitetssjukhuset Huddinge
  • Stockholm, Sweden, 171 76
    • Karolinska Universitetssjukhuset Solna
• Taiwan
  • Kaohsiung City, Taiwan, 80756
    • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • New Taipei City, Taiwan, 25160
    • Mackay Memorial Hospital Tamsui Branch
  • Taichung, Taiwan, 40201
    • Chung Shan Medical University Hospital
  • Taichung, Taiwan, 40705
    • Veterans General Hospital - Taichung
  • Tainan, Taiwan, 70403
    • National Cheng Kung University Hospital
  • Taipei, Taiwan, 10002
    • National Taiwan University Hospital
  • Taipei, Taiwan, 11101
    • Shin Kong Wu Ho-Su Memorial Hospital
  • Taoyuan District, Taiwan, 33305
    • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
  • Hualien
    • Hualien City, Hualien, Taiwan, 97002
      • Hualien Tzu Chi Hospital
• United Kingdom
  • Belfast, United Kingdom, BT72EB
    • Ormeau Clinical Trials Ltd
  • Birmingham, United Kingdom, DY1 2HQ
    • Russell Hall Hospital
  • Blackpool, United Kingdom, FY3 8NR
    • NIHR Patient Recruitment Centre Blackpool
  • Bradford, United Kingdom, BD9 6RJ
    • NIHR Patient Recruitment Centre Bradford
  • Bristol, United Kingdom, BS37 4AX
    • West Walk Surgery
  • Chichester, United Kingdom, PO19 6SE
    • St Richards Hospital
  • Chippenham, United Kingdom, SN15 2SB
    • Rowden Surgery
  • Craigavon, United Kingdom, BT63 5QQ
    • Craigavon Area Hospital
  • Enfield, United Kingdom, EN3 4GS
    • Panthera Biopartners - London
  • Exeter, United Kingdom, EX2 5DW
    • NIHR Patient Recruitment Centre Exeter
  • Glasgow, United Kingdom, G51 4TY
    • Panthera Biopartners - Glasgow
  • Harefield, United Kingdom, UB9 6JH
    • Harefield Hospital
  • High Wycombe, United Kingdom, HP11 2TT
    • Wycombe General Hospital
  • Inverness, United Kingdom, IV2 3JH
    • Highlands Clinical Research Facility, Raigmore Hospital
  • Leicester, United Kingdom, LE5 4PW
    • NIHR Patient Recruitment Centre Leicester
  • Lincoln, United Kingdom, LN2 5QY
    • Lincoln County Hospital
  • London, United Kingdom, W12 0HS
    • Hammersmith Hospital
  • London, United Kingdom, EC1M 6BQ
    • Queen Mary University of London
  • Penarth, United Kingdom, CF64 2XX
    • University Hospital Llandough
  • Poole, United Kingdom, BH16 5PW
    • The Adam Practice
  • Preston, United Kingdom, PR2 9QB
    • Panthera Biopartners - Preston
  • Stevenage, United Kingdom, SG1 4AB
    • Lister Hospital
• United States
  • Alabama
    • Birmingham, Alabama, United States, 35211
      • Ascension Saint Vincents Birmingham
    • Birmingham, Alabama, United States, 35243
      • Grandview Medical Center Affinity Cardiovascular Specialists, LLC
    • Huntsville, Alabama, United States, 35801
      • Heart Center Research LLC
    • Mobile, Alabama, United States, 36608
      • Mobile Heart Specialists PC
  • Alaska
    • Anchorage, Alaska, United States, 99508
      • Alaska Cardiovascular Research Foundation
  • Arizona
    • Phoenix, Arizona, United States, 85018
      • Elite Clinical Studies LLC
    • Scottsdale, Arizona, United States, 85258
      • HonorHealth Research and Innovation Institute
  • California
    • Beverly Hills, California, United States, 90211
      • Vitality Clinical Research
    • Beverly Hills, California, United States, 90211
      • National Heart Institute
    • La Jolla, California, United States, 92037
      • University of California San Diego
    • Los Angeles, California, United States, 90073
      • VA Greater Los Angeles Healthcare System
    • Orange, California, United States, 92868
      • University of California Irvine
    • Santa Monica, California, United States, 90404
      • University of California Los Angeles
    • Stockton, California, United States, 95204
      • Manshadi Heart Institute
    • Toluca Lake, California, United States, 91602
      • Med Partners, Inc dba Premiere Medical Center, Inc
  • Colorado
    • Colorado Springs, Colorado, United States, 80909
      • UCHealth Memorial Central
  • Connecticut
    • Stamford, Connecticut, United States, 06905
      • Cardiology Associates of Fairfield County PC
  • District of Columbia
    • Washington D.C., District of Columbia, United States, 20010
      • MedStar Clinical Research
  • Florida
    • Boca Raton, Florida, United States, 33434
      • Excel Medical Clinical Trials
    • Brandon, Florida, United States, 33511
      • Bay Area Cardiology
    • Clearwater, Florida, United States, 33756
      • Clearwater Cardiovascular Consultants
    • Daytona Beach, Florida, United States, 32117
      • Cardiology Associates Research LLC
    • Fort Lauderdale, Florida, United States, 33312
      • Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care
    • Hialeah, Florida, United States, 33013
      • Elite Cardiac Research Center LLC
    • Jacksonville, Florida, United States, 32205
      • Westside Center For Clinical Research
    • Jacksonville, Florida, United States, 32216
      • Jacksonville Center for Clinical Research
    • Jacksonville, Florida, United States, 32209
      • University of Florida
    • Jacksonville, Florida, United States, 32204
      • East Coast Institute for Research, LLC
    • Jacksonville, Florida, United States, 32216
      • East Coast Institute For Research LLC
    • Naples, Florida, United States, 34102
      • Advanced Research for Health Improvement, LLC
    • Ocala, Florida, United States, 34471
      • Ocala Cardiovascular Research
    • Orlando, Florida, United States, 32803
      • AdventHealth Medical Group Cardiology at Orlando
    • Saint Augustine, Florida, United States, 32086
      • East Coast Institute for Research, LLC
    • Saint Augustine, Florida, United States, 32086
      • Saint Johns Center for Clinical Research
    • Sarasota, Florida, United States, 34239
      • Cardiovascular Center of Sarasota
    • Tampa, Florida, United States, 33625
      • Care Access - Tampa
  • Georgia
    • Atlanta, Georgia, United States, 30309
      • Piedmont Healthcare
    • Atlanta, Georgia, United States, 30310
      • Morehouse School of Medicine
    • Cumming, Georgia, United States, 30041
      • Northeast Georgia Medical Center Wisteria Building
    • Johns Creek, Georgia, United States, 30024
      • Nsc Research
  • Idaho
    • Meridian, Idaho, United States, 83642
      • St Lukes Idaho Cardiology Associates
  • Illinois
    • Arlington Heights, Illinois, United States, 60005
      • Northwest Heart Clinical Research LLC
    • Evanston, Illinois, United States, 60201
      • Northshore University Health System
    • Park Ridge, Illinois, United States, 60068
      • Advocate Lutheran General Hospital
  • Indiana
    • Munster, Indiana, United States, 46321
      • Cardiovascular Research of Northwest Indiana LLC
    • Richmond, Indiana, United States, 47374
      • Reid Physician Associates
  • Iowa
    • West Des Moines, Iowa, United States, 50266
      • MercyOne Iowa Heart Center
  • Kansas
    • Kansas City, Kansas, United States, 66160
      • University of Kansas Medical Center
    • Overland Park, Kansas, United States, 66211
      • Midwest Heart and Vascular Specialists
  • Kentucky
    • Covington, Kentucky, United States, 41011
      • Saint Elizabeth Covington
    • Lexington, Kentucky, United States, 40503
      • The Research Group of Lexington LLC
    • Louisville, Kentucky, United States, 40202
      • University of Louisville Health - Jewish Hospital
  • Louisiana
    • Hammond, Louisiana, United States, 70403
      • Louisiana Heart Center
    • Lake Charles, Louisiana, United States, 70601
      • Care Access - Lake Charles
    • Monroe, Louisiana, United States, 71201
      • Clinical Trials of America Inc
    • West Monroe, Louisiana, United States, 71291
      • Monroe Research LLC
  • Maine
    • Bangor, Maine, United States, 04401
      • Northern Light Eastern Maine Medical Center
  • Maryland
    • Baltimore, Maryland, United States, 21287
      • Johns Hopkins University School of Medicine
    • Baltimore, Maryland, United States, 21201
      • University of Maryland Medical Center
    • Baltimore, Maryland, United States, 21229
      • Maryland Cardiovascular Specialists
    • Beltsville, Maryland, United States, 20705
      • Metropolitan Cardiovascular Consultants LLC
    • Salisbury, Maryland, United States, 21804
      • TidalHealth Peninsula Regional, Inc
  • Massachusetts
    • Boston, Massachusetts, United States, 02115
      • Brigham and Womens Hospital
  • Michigan
    • Detroit, Michigan, United States, 48202
      • Henry Ford Hospital
    • Detroit, Michigan, United States, 48236
      • Ascension Saint John Hospital
    • Grand Rapids, Michigan, United States, 49546
      • Healthy Heart Cardiology
    • Grand Rapids, Michigan, United States, 49546
      • Advanced Cardiology Associates
    • Lansing, Michigan, United States, 48912
      • Sparrow Clinical Research Institute
    • Troy, Michigan, United States, 48098
      • Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division
  • Minnesota
    • Maplewood, Minnesota, United States, 55109
      • Fairview Health Services
    • Minneapolis, Minnesota, United States, 55455
      • University of Minnesota
    • Minneapolis, Minnesota, United States, 55407
      • Minneapolis Heart Institute Foundation
    • Rochester, Minnesota, United States, 55902
      • Mayo Clinic Rochester
  • Mississippi
    • Tupelo, Mississippi, United States, 38801
      • Cardiology Associates Research LLC
  • Missouri
    • St Louis, Missouri, United States, 63136
      • Saint Louis Heart and Vascular PC
  • Nebraska
    • Lincoln, Nebraska, United States, 68506
      • Bryan Heart
  • Nevada
    • Las Vegas, Nevada, United States, 89128
      • Palm Research Center Inc
    • Reno, Nevada, United States, 89502
      • Renown Institute for Heart and Vascular Health
  • New Jersey
    • Newark, New Jersey, United States, 07102
      • Saint Michaels Medical Center
    • Summit, New Jersey, United States, 91010
      • Overlook Medical Center
  • New York
    • Cortlandt Manor, New York, United States, 10567
      • New York Presbyterian Medical Group Hudson Valley Cardiology
    • Kew Gardens, New York, United States, 11415
      • Elligo Health Research
    • Kingston, New York, United States, 12401
      • WMCHealth Heart and Vascular Institute Kingston Division of Cardiology
    • Manhasset, New York, United States, 11030
      • Northwell Health Physician Partners Cardiology at Manhasset
    • New York, New York, United States, 10029
      • Icahn School Of Medicine At Mount Sinai
    • New York, New York, United States, 10016
      • New York University Langone Health
    • New York, New York, United States, 10022
      • Northwell Health Lenox Hill Heart and Vascular
    • New York, New York, United States, 10029
      • Icahn School of Medicine at Mount Sinai Queens
    • Riverhead, New York, United States, 11901
      • Northwell Health Physician Partners at Peconic
    • Stony Brook, New York, United States, 11794
      • Stony Brook University Hospital
    • Valhalla, New York, United States, 10595
      • Westchester Medical Center
    • Woodhaven, New York, United States, 11421
      • NY Family Docs
  • North Carolina
    • Asheville, North Carolina, United States, 28803
      • Asheville Cardiology Associates
    • Charlotte, North Carolina, United States, 28204
      • Novant Health Heart and Vascular Institute
    • Durham, North Carolina, United States, 27710
      • Duke University
    • Greensboro, North Carolina, United States, 27401
      • Moses H Cone Memorial Hospital
    • Mooresville, North Carolina, United States, 28117
      • Lapis Clinical Research
    • Winston-Salem, North Carolina, United States, 27157
      • Wake Forest University Health Sciences
  • North Dakota
    • Fargo, North Dakota, United States, 58104
      • Lillestol Research LLC
  • Ohio
    • Cincinnati, Ohio, United States, 45220
      • TriHealth Good Samaritan Hospital
    • Cleveland, Ohio, United States, 44106
      • University Hospitals Cleveland Medical Center
    • Columbus, Ohio, United States, 43214
      • The OhioHealth Research Institute
    • Kettering, Ohio, United States, 45429
      • Kettering Medical Center
    • Marion, Ohio, United States, 43302
      • Rama Research LLC
  • Oregon
    • Portland, Oregon, United States, 97239
      • Oregon Health and Science University
  • Pennsylvania
    • Newport, Pennsylvania, United States, 17074
      • Capital Area Research LLC
    • Philadelphia, Pennsylvania, United States, 19104
      • University of Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19141
      • Montefiore Medical Center - Bronx
    • Pittsburgh, Pennsylvania, United States, 15212
      • Allegheny General Hospital
  • South Carolina
    • Charleston, South Carolina, United States, 29425
      • Medical University of South Carolina
    • Columbia, South Carolina, United States, 29203
      • Prisma Health Midlands Cardiology
    • Fort Mill, South Carolina, United States, 29707
      • Piedmont Research Partners
  • South Dakota
    • Rapid City, South Dakota, United States, 57701
      • Monument Health Clinical Research
  • Tennessee
    • Germantown, Tennessee, United States, 38138
      • Stern Cardiovascular Foundation Inc
    • Tullahoma, Tennessee, United States, 37388
      • Tennessee Center for Clinical Trials
  • Texas
    • Austin, Texas, United States, 78731
      • Texas Diabetes and Endocrinology
    • Dallas, Texas, United States, 75235
      • Southwest Family Medicine Associates
    • Dallas, Texas, United States, 75226
      • Baylor Scott and White Heart and Vascular Hospital-Dallas
    • El Paso, Texas, United States, 79905
      • David Turbay, MD
    • Georgetown, Texas, United States, 78633
      • Care Access - Georgetown
    • Houston, Texas, United States, 77030
      • Baylor College of Medicine
    • Kingwood, Texas, United States, 77339
      • Texas Cardiology Associates of Houston
    • McKinney, Texas, United States, 75071
      • Texas Institute Of Cardiology
    • Odessa, Texas, United States, 79761
      • Permian Research Foundation
    • Tomball, Texas, United States, 77375
      • Northwest Houston Heart Center
  • Virginia
    • Fairfax, Virginia, United States, 22031
      • Inova Heart and Vascular Institute
    • Falls Church, Virginia, United States, 22042
      • Virginia Heart
    • Leesburg, Virginia, United States, 20176
      • Virginia Heart - Loudoun
    • Manassas, Virginia, United States, 20109
      • Carient Heart and Vascular
    • Midlothian, Virginia, United States, 23114
      • Bon Secours Cardiology
    • Newport News, Virginia, United States, 23606
      • Tidewater Physicians Multispecialty Group Clinical Research
    • Winchester, Virginia, United States, 22601
      • Winchester Cardiology and Vascular Medicine
  • Washington
    • Puyallup, Washington, United States, 98372
      • Pulse Heart Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age 18 to ≤ 85 years
• Lp(a) ≥ 200 nmol/L during screening

• History of ASCVD as evidenced by history of either:

  • Myocardial infarction (presumed type 1 event due to plaque rupture/erosion) and/or
  • Coronary revascularization with percutaneous coronary intervention AND at least 1 additional risk factor.

Exclusion Criteria:

• Severe renal dysfunction
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN), or total bilirubin (TBL) > 2 x ULN during screening
• History of hemorrhagic stroke
• History of major bleeding disorder
• Planned cardiac surgery or arterial revascularization
• Severe heart failure
• Current, recent, or planned lipoprotein apheresis
• Previously received ribonucleic acid therapy specifically targeting Lp(a)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo; Placebo will be administered by subcutaneous injection.	Drug: Placebo; Placebo given by subcutaneous injection once every 12 weeks (Q12W).
Experimental: Olpasiran; Olpasiran will be administered by subcutaneous injection.	Drug: Olpasiran; Olpasiran given by subcutaneous injection Q12W.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Time to CHD death, myocardial infarction, or urgent coronary revascularization, whichever occurs first	Approximately 5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Percent change from baseline to Week 48 in Lipoprotein(a)	Baseline and Week 48
Time to cardiovascular death, myocardial infarction, or ischemic stroke, whichever occurs first	Approximately 5 years
Time to cardiovascular death, myocardial infarction, urgent coronary revascularization, or ischemic stroke, whichever occurs first	Approximately 5 years
Time to myocardial infarction	Approximately 5 years
Time to CHD death or myocardial infarction, whichever occurs first	Approximately 5 years
Time to urgent coronary revascularization	Approximately 5 years
Time to coronary revascularization	Approximately 5 years
Time to CHD death	Approximately 5 years
Time to cardiovascular death	Approximately 5 years
Time to death by any cause	Approximately 5 years
Time to ischemic stroke	Approximately 5 years

Collaborators and Investigators

• Sponsor: Amgen
• Investigators: Study Director: MD, Amgen

Publications and helpful links

General Publications

• Nicholls SJ, Nelson AJ, Michael LF. Oral agents for lowering lipoprotein(a). Curr Opin Lipidol. 2024 Dec 1;35(6):275-280. doi: 10.1097/MOL.0000000000000953. Epub 2024 Sep 25.
• Dimitriadis K, Theofilis P, Iliakis P, Pyrpyris N, Dri E, Sakalidis A, Soulaidopoulos S, Tsioufis P, Fragkoulis C, Chrysohoou C, Tsiachris D, Tsioufis K. Management of dyslipidemia in coronary artery disease: the present and the future. Coron Artery Dis. 2024 Sep 1;35(6):516-524. doi: 10.1097/MCA.0000000000001375. Epub 2024 Apr 29.
• Karp A, Jacobs M, Barris B, Labkowsky A, Frishman WH. Lipoprotein(a): A Review of Risk Factors, Measurements, and Novel Treatment Modalities. Cardiol Rev. 2025 Jul-Aug 01;33(4):352-358. doi: 10.1097/CRD.0000000000000667. Epub 2024 Feb 28.
• Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2025 Dec 2. doi: 10.2215/CJN.0000000968. Online ahead of print.

Helpful Links

• AmgenTrials clinical trials website

Study record dates

Study Major Dates

• Study Start (Actual): December 14, 2022
• Primary Completion (Estimated): March 31, 2028
• Study Completion (Estimated): March 31, 2028

Study Registration Dates

• First Submitted: October 12, 2022
• First Submitted That Met QC Criteria: October 12, 2022
• First Posted (Actual): October 14, 2022

Study Record Updates

• Last Update Posted (Actual): February 27, 2026
• Last Update Submitted That Met QC Criteria: February 25, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Olpasiran; AMG 890; ASCVD; Atherosclerotic Cardiovascular Disease
• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Atherosclerosis; olpasiran
• Other Study ID Numbers: 20180244; 2022-501608-85 (EudraCT Number)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.
• IPD Sharing Time Frame: Data sharing requests relating to this trial will be considered beginning 18 months after the trial has ended and either 1) the product and indication (or other new use) have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this trial.
• IPD Sharing Access Criteria: Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen trial/trials in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors, and if not approved, may be further arbitrated by a Data Sharing Independent Review Panel. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the link below.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP; ICF; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No