A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

March 10, 2026 updated by: Novo Nordisk A/S

Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires.

Study Overview

Status

Recruiting

Conditions

Heart Failure

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

5600

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Novo Nordisk
Phone Number: (+1) 866-867-7178
Email: clinicaltrials@novonordisk.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1181ACH
    - Active, not recruiting
    - Hospital Italiano
  - Buenos Aires, Argentina, C1181ACH
    - Recruiting
    - Hospital Italiano
  - Buenos Aires, Argentina, C1426ABP
    - Active, not recruiting
    - Fundación Respirar
  - Buenos Aires, Argentina, B1704ETD
    - Recruiting
    - DIM Clínica Privada
  - Buenos Aires, Argentina, B1704ETD
    - Active, not recruiting
    - DIM Clínica Privada
  - CABA, Argentina, C1093AAS
    - Recruiting
    - Fundacion Favaloro
  - CABA, Argentina, C1093AAS
    - Not yet recruiting
    - Fundacion Favaloro
  - CABA, Argentina, C1440CFD
    - Recruiting
    - CEMEDIC
  - Corrientes, Argentina, W3400AMZ
    - Recruiting
    - Instituto de Cardiologia de Corrientes
  - Corrientes, Argentina, W3400AMZ
    - Active, not recruiting
    - Instituto de Cardiologia de Corrientes
  - Mar del Plata, Argentina, B7600FZN
    - Active, not recruiting
    - Instituto de Investigaciones Clínicas Mar del Plata
  - Mar del Plata, Argentina, B7600FZN
    - Recruiting
    - Instituto de Investigaciones Clinicas
  - Mar del Plata, Argentina, B7600GNY
    - Recruiting
    - Centro de Investigaciones Médicas Clínica de Fracturas y Or
  - San Nicolás, Argentina, B2900
    - Recruiting
    - Instituto de Investigaciones Clinicas San Nicolas
  - San Nicolás, Argentina, B2900
    - Active, not recruiting
    - Instituto de Investigaciones Clinicas San Nicolas
  - Santa Fe, Argentina, 3000
    - Recruiting
    - Centro de Investigaciones Clinicas del Litoral
  - Santa Fe, Argentina, 3000
    - Active, not recruiting
    - Centro de Investigaciones Clinicas del Litoral
  - Santa Fe, Argentina, S3000FSO
    - Completed
    - CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1128 AAF
    - Recruiting
    - Mautalen Salud e Investigación
  - CABA, Buenos Aires, Argentina, C1128 AAF
    - Active, not recruiting
    - Mautalen Salud e Investigación
  - CABA, Buenos Aires, Argentina, C1440CFD
    - Active, not recruiting
    - CEMEDIC
  - Mar del Plata, Buenos Aires, Argentina, B7600GNY
    - Recruiting
    - Centro de Investigaciones Médicas Clínica de Fracturas y Or
  - Mar del Plata, Buenos Aires, Argentina, B7600GNY
    - Active, not recruiting
    - Centro de Investigaciones Medicas Mar Del Plata
- Buenos Aires, Argentina
  - CABA, Buenos Aires, Argentina, Argentina, C1093AAS
    - Active, not recruiting
    - Fundacion Favaloro
- Santa Fe Province
  - Granadero Baigorria, Santa Fe Province, Argentina, 2152
    - Recruiting
    - Centro de Investigaciones Clinica Baigorria
  - Santa Fé, Santa Fe Province, Argentina, 2152
    - Active, not recruiting
    - Centro de Investigaciones Clinica Baigorria
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Active, not recruiting
    - Canberra Hospital
- New South Wales
  - Concord, New South Wales, Australia, 2139
    - Active, not recruiting
    - Concord Repatriation General Hospital - Cardiology Department
  - Gosford, New South Wales, Australia, 2250
    - Active, not recruiting
    - Gosford Hospital
  - Liverpool, New South Wales, Australia, 2170
    - Active, not recruiting
    - Sydney Cardiometabolic Centre
- Queensland
  - Brisbane, Queensland, Australia, 4029
    - Recruiting
    - Royal Brisbane and Women's Hospital
  - Brisbane, Queensland, Australia, 4029
    - Active, not recruiting
    - Royal Brisbane and Women's Hospital
  - Chelmer, Queensland, Australia, 4068
    - Active, not recruiting
    - Heart of Australia
  - Douglas, Queensland, Australia, 4814
    - Active, not recruiting
    - Townsville University Hospital
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Active, not recruiting
    - Nightingale Research
  - Adelaide, South Australia, Australia, 5000
    - Active, not recruiting
    - Royal Adelaide Hospital - Cardiology Department
  - Bedford Park, South Australia, Australia, 5042
    - Active, not recruiting
    - Flinders Medical Centre
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Recruiting
    - Royal Hobart Hospital
  - Hobart, Tasmania, Australia, 7000
    - Active, not recruiting
    - Royal Hobart Hospital
- Victoria
  - Frankston, Victoria, Australia, 3199
    - Recruiting
    - Frankston Hospital
  - Frankston, Victoria, Australia, 3199
    - Active, not recruiting
    - Peninsula University Hospital - Cardiology Department
  - Geelong, Victoria, Australia, 3220
    - Recruiting
    - Barwon Health (The Geelong Hospital)
  - Geelong, Victoria, Australia, 3220
    - Active, not recruiting
    - Adrian Costa Clinical Trials Centre
  - Hoppers Crossing, Victoria, Australia, 3029
    - Completed
    - HeartWest Cardiology - Hoppers Crossing
  - Richmond, Victoria, Australia, 3121
    - Withdrawn
    - Epworth Healthcare
  - Richmond, Victoria, Australia, 3121
    - Completed
    - Epworth Healthcare
- Western Australia
  - Perth, Western Australia, Australia, 6000
    - Active, not recruiting
    - Clinitrials
Austria
- - Braunau am Inn, Austria, A 5280
    - Not yet recruiting
    - Krankenhaus St. Josef Braunau
  - Braunau am Inn, Austria, 5280
    - Active, not recruiting
    - Krankenhaus St. Josef Braunau
  - Graz, Austria, A 8036
    - Recruiting
    - Medizinische Universität Graz
  - Graz, Austria, 8036
    - Active, not recruiting
    - Medizinische Universität Graz
  - Saint Stefan, Austria, 8511
    - Not yet recruiting
    - Fließer-Görzer [Ordination]
  - Saint Stefan, Austria, 8511
    - Active, not recruiting
    - Fließer-Görzer [Ordination]
  - Salzburg, Austria, 5020
    - Active, not recruiting
    - Uniklinikum Salzburg Kardiologie
  - Vienna, Austria, 1090
    - Not yet recruiting
    - Medizinische Universitat Wien
  - Vienna, Austria, 1100
    - Not yet recruiting
    - Klinik Favoriten
  - Vienna, Austria, A 1190
    - Not yet recruiting
    - Imed 19- privat
  - Vienna, Austria, 1190
    - Active, not recruiting
    - Imed 19- privat
  - Vienna, Austria, 1090
    - Completed
    - Medizinische Universitat Wien
  - Vienna, Austria, 1100
    - Completed
    - Klinik Favoriten
  - Vienna, Austria, 1160
    - Completed
    - Klinik Ottakring
Belgium
- - Aalst, Belgium, 9300
    - Active, not recruiting
    - AZORG Aalst - Moorselbaan
  - Brussels, Belgium, 1090
    - Active, not recruiting
    - UZ Brussel
  - Edegem, Belgium, 2650
    - Active, not recruiting
    - UZA - UZ Antwerpen - Cardiology Department
  - Genk, Belgium, 3600
    - Active, not recruiting
    - Ziekenhuis Oost-Limburg AV - Cardiology
  - Kortrijk, Belgium, 8500
    - Active, not recruiting
    - AZ Groeninge - Kortrijk - Cardiology
  - Liège, Belgium, 4000
    - Active, not recruiting
    - CHR de la Citadelle
Bosnia and Herzegovina
- - Banja Luka, Bosnia and Herzegovina, 78000
    - Active, not recruiting
    - University Clinical Centre of the Republic Srpska
  - Sarajevo, Bosnia and Herzegovina, 71000
    - Recruiting
    - Dr. Abdulah Nakas General Hospital
  - Sarajevo, Bosnia and Herzegovina, 71000
    - Active, not recruiting
    - Dr. Abdulah Nakas General Hospital
  - Sarajevo, Bosnia and Herzegovina, 71000
    - Active, not recruiting
    - University Clinical Centre Sarajevo
Brazil
- - Aracaju, Brazil, 49055-530
    - Active, not recruiting
    - jmf Clinica do Coracao ltda
  - Goiânia/GO, Brazil, 74605-020
    - Recruiting
    - Hospital de Clínicas da Universidade Federal de Goiânia
  - Marília/SP, Brazil, 17515-000
    - Recruiting
    - ICM - Instituto do Coracao de Marilia
  - Porto Alegre/RS, Brazil, 90840-440
    - Recruiting
    - Hospital Mãe de Deus - Porto Alegre
  - Recife/PE, Brazil, 56517-630
    - Completed
    - PROCAPE
  - Rio de Janeiro, Brazil, 22061-080
    - Recruiting
    - Hospital São Lucas Copacabana
  - Rio de Janeiro, Brazil, 22281-100
    - Completed
    - Instituto D'Or de Pesquisa e Ensino
  - São Paulo/SP, Brazil, 04026-090
    - Not yet recruiting
    - Universidade Federal de São Paulo - UNIFESP
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29055-450
    - Completed
    - Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - Recruiting
    - CCIH-Consultoria em Controle de Infecção Hospitalar Ltda
  - Belo Horizonte, Minas Gerais, Brazil, 30220-140
    - Recruiting
    - NUPEC Cardio
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - Active, not recruiting
    - CCIH-Consultoria em Controle de Infecção Hospitalar Ltda
  - Uberlândia, Minas Gerais, Brazil, 38400-500
    - Recruiting
    - Eurolatino Medical Research Center
- Paraná
  - Campina Grande do Sul, Paraná, Brazil, 83430-000
    - Active, not recruiting
    - Sociedade Hospitalar Angelina Caron, Brazil
  - Curitiba, Paraná, Brazil, 80230-130
    - Recruiting
    - PUCPR - Pontificia Universidade Catolica do Parana
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90035-003
    - Recruiting
    - Hospital de Clínicas de Porto Alegre
- São Paulo
  - Bragança Paulista, São Paulo, Brazil, 12916-542
    - Active, not recruiting
    - Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
  - Campinas, São Paulo, Brazil, 13060-080
    - Recruiting
    - Instituto de Pesquisa clinica de Campinas
  - Campinas, São Paulo, Brazil, 13060-803
    - Recruiting
    - PUCCAMP - Hospital e Maternidade Celso Pierro
  - Campinas, São Paulo, Brazil, 13092-133
    - Recruiting
    - i9 Pesquisas Clínicas
  - Ribeirão Preto, São Paulo, Brazil, 14051-140
    - Completed
    - Unidade de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
  - São José do Rio Preto, São Paulo, Brazil, 15090-000
    - Recruiting
    - CIP Centro Integrado de Pesquisas do Hospital de Base
  - Tatuí, São Paulo, Brazil, 18270-170
    - Active, not recruiting
    - Instituto de Moléstias Cardiovasculares de Tatuí Ltda
  - Votuporanga, São Paulo, Brazil, 15500-269
    - Recruiting
    - Integral Pesquisa e Ensino
Bulgaria
- - Burgas, Bulgaria, 8000
    - Completed
    - MHAT Heart and Brain EAD - Burgas, Cardiology
  - Kardzhali, Bulgaria, 6600
    - Completed
    - Medical Centre - Avitsena EOOD
  - Kozloduy, Bulgaria, 3320
    - Recruiting
    - Medical centre "Zdrave 1" OOD
  - Kozloduy, Bulgaria, 3320
    - Recruiting
    - Medical centre Zdrave 1 OOD
  - Kyustendil, Bulgaria, 2500
    - Active, not recruiting
    - Medical Centre Hera - Kyustendil EOOD
  - Lom, Bulgaria, 3600
    - Recruiting
    - Diagnostic Consulting Center 1- Lom EOOD
  - Lom, Bulgaria, 3600
    - Active, not recruiting
    - DCC 1 - Lom EOOD
  - Panagyurishte, Bulgaria, 4500
    - Recruiting
    - "MHAT - UniHospital" OOD
  - Panagyurishte, Bulgaria, 4500
    - Active, not recruiting
    - MHAT - UniHospital OOD
  - Pleven, Bulgaria, 5800
    - Active, not recruiting
    - Medical center Medconsult Pleven OOD
  - Pleven, Bulgaria, 5804
    - Active, not recruiting
    - MHAT Heart and Brain EAD - Pleven, Cardiology
  - Pleven, Bulgaria, 5800
    - Completed
    - UMHAT - Dr. Georgi Stranski EAD
  - Plovdiv, Bulgaria, 4002
    - Active, not recruiting
    - UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
  - Plovdiv, Bulgaria, 4002
    - Active, not recruiting
    - UMHAT - Plovdiv AD
  - Plovdiv, Bulgaria, 4004
    - Active, not recruiting
    - MHAT Sveta Karidad EAD
  - Sandanski, Bulgaria, 2800
    - Recruiting
    - MC Health Care OOD, Sandanski
  - Sevlievo, Bulgaria, 5400
    - Recruiting
    - 'Medical Center Hipokrena' EOOD
  - Sevlievo, Bulgaria, 5400
    - Active, not recruiting
    - Medical Center Hipokrena EOOD
  - Sliven, Bulgaria, 8801
    - Active, not recruiting
    - Medical Centre Cardiomed 2020 EOOD
  - Sofia, Bulgaria, 1527
    - Active, not recruiting
    - Medical center ISUL - Tsaritsa Yoanna EOOD
  - Sofia, Bulgaria, 1680
    - Recruiting
    - Medical Centre Intermedica OOD
  - Sofia, Bulgaria, 1404
    - Recruiting
    - MHAT Sveta Sofia EOOD
  - Sofia, Bulgaria, 1202
    - Active, not recruiting
    - DCC Ascendent OOD
  - Sofia, Bulgaria, 1431
    - Active, not recruiting
    - DCC Aleksandrovska EOOD
  - Sofia, Bulgaria, 1233
    - Active, not recruiting
    - MHAT Knyaginya Klementina - Sofia EAD
  - Sofia, Bulgaria, 1233
    - Active, not recruiting
    - NMTH Tsar Boris III
  - Stara Zagora, Bulgaria, 6000
    - Completed
    - Medical Center Zara-Med EOOD
  - Veliko Tarnovo, Bulgaria, 5000
    - Active, not recruiting
    - MDHAT Dr. Stephen Cherkezov AD
  - Veliko Tarnovo, Bulgaria, 5006
    - Active, not recruiting
    - MC Nevromedics EOOD, Cardiology
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4Z6
    - Recruiting
    - University of Calgary_Calgary
  - Edmonton, Alberta, Canada, T5A 4L8
    - Recruiting
    - Alta Clinical Research
- British Columbia
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Recruiting
    - Royal Columbian Hospital
  - North Vancouver, British Columbia, Canada, V7M 2H4
    - Recruiting
    - North Shore Heart Centre
  - North Vancouver, British Columbia, Canada, V7M 2H4
    - Not yet recruiting
    - North Shore Heart Centre
  - Surrey, British Columbia, Canada, V3V 0C6
    - Recruiting
    - SMH Cardiology Clinical Trials Inc.
  - Vancouver, British Columbia, Canada, V6Z1Y6
    - Recruiting
    - St Pauls Hospital
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Recruiting
    - Ctr for Cardiovascular Innovation
  - Victoria, British Columbia, Canada, V8R 1B2
    - Recruiting
    - Victoria Heart Institute Foundation
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2HA6
    - Recruiting
    - St. Boniface Hospital
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - Recruiting
    - G.A. Research Associates Ltd.
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Recruiting
    - Nova Scotia Health
- Ontario
  - Cambridge, Ontario, Canada, N1R 6V6
    - Recruiting
    - Cambridge Cardiac Care Centre
  - Cambridge, Ontario, Canada, N1R 7R1
    - Recruiting
    - Saul Vizel Pro. Med. Corp
  - Greater Sudbury, Ontario, Canada, P3E 5J1
    - Recruiting
    - Health Sciences North Rsrch Inst
  - Guelph, Ontario, Canada, N1H 1B1
    - Recruiting
    - Dawson Clinical Research
  - Hamilton, Ontario, Canada, L8L 2X2
    - Recruiting
    - Hamilton Hlth Sc. - General Site
  - London, Ontario, Canada, N6A 4V2
    - Recruiting
    - St. Joseph's Hospital
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Recruiting
    - Partnrs Adv Cardio Eval (PACE)
  - North York, Ontario, Canada, M6B 3H7
    - Recruiting
    - North York Diagn & Cardiac Ctr
  - Oshawa, Ontario, Canada, L1J 2K9
    - Recruiting
    - Centricity Research Oshawa
  - Peterborough, Ontario, Canada, K9J 0B2
    - Recruiting
    - Kawartha Cardiology Clinical Trials
  - Toronto, Ontario, Canada, M6G 1M2
    - Recruiting
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M5S 1B1
    - Recruiting
    - Women's College Hospital
  - Toronto, Ontario, Canada, M5B 1W8
    - Recruiting
    - St. Michael's Hospital_Toronto
  - Waterloo, Ontario, Canada, N2T 0C1
    - Recruiting
    - CPS Research
  - Waterloo, Ontario, Canada, N2T 0C1
    - Recruiting
    - Clinical Research Solutions Inc.
  - Winchester, Ontario, Canada, K0C 2K0
    - Recruiting
    - Winchester Dist Memorial Hosp
- Quebec
  - Longueuil, Quebec, Canada, J4H4B9
    - Recruiting
    - Viacar Recherche Clinique Inc.
  - Montreal, Quebec, Canada, H1T 1C8
    - Recruiting
    - Institut de Cardiologie de Montreal
  - Montreal, Quebec, Canada, H2X 0C1
    - Recruiting
    - CHU de Montréal
  - Saint-Jean-sur-Richelieu, Quebec, Canada, J3A 1J2
    - Completed
    - CardioVasc HR Inc
  - Sherbrooke, Quebec, Canada, J1G 2E8
    - Completed
    - CIUSSS de l'E CHUS_Sherbrooke
  - Terrebonne, Quebec, Canada, J6X 4P7
    - Recruiting
    - Ctr de méd métab de Lanaudière
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Completed
    - CISSSL Hôsp Pierre-Le Gardeur
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Recruiting
    - Diex Recherche Trois-Rivieres
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 0W8
    - Recruiting
    - Royal University Hospital
China
- - Chongqing, China, 404000
    - Recruiting
    - Chongqing University Three Gorges Hospital
  - Shanghai, China, 20031
    - Recruiting
    - Shanghai Xuhui Central Hospital
- Anhui
  - Huainan, Anhui, China, 232007
    - Recruiting
    - The First Hospital of Anhui University of Science & Technology (Huainan First People's Hospital)-Cardiology
- Beijing Municipality
  - Beijing, Beijing Municipality, China, 100029
    - Recruiting
    - Beijing Anzhen Hospital, Capital Medical University
  - Beijing, Beijing Municipality, China, 100029
    - Recruiting
    - China-Japan Friendship Hospital
  - Beijing, Beijing Municipality, China, 100029
    - Not yet recruiting
    - China-Japan Friendship Hospital
  - Beijing, Beijing Municipality, China, 100037
    - Recruiting
    - Chinese Academy of Medical Sciences Fuwai Hospital
  - Beijing, Beijing Municipality, China, 100191
    - Recruiting
    - Peking University Third Hospital-Cardiology
- Chongqing Municipality
  - Chongqing, Chongqing Municipality, China, 400042
    - Recruiting
    - The First Affiliated Hospital of Chongqing Medical University-Cardiology
  - Chongqing, Chongqing Municipality, China, 400060
    - Recruiting
    - The Second Affiliated Hospital of Chongqing Medical University
  - Chongqing, Chongqing Municipality, China, 404000
    - Recruiting
    - Chongqing University Three Gorges Hospital
- Gansu
  - Lanzhou, Gansu, China, 730030
    - Recruiting
    - The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular
- Guangdong
  - Guangzhou, Guangdong, China, 510120
    - Recruiting
    - Sun Yat-sen Memorial Hospital, Sun Yat-sen University
  - Guangzhou, Guangdong, China, 510630
    - Recruiting
    - The First Affiliated Hospital of Jinan University
  - Guangzhou, Guangdong, China, 510120
    - Recruiting
    - Sun Yat-sen Memorial Hospital, Sun Yat-sen Universtiy
  - Shantou, Guangdong, China, 515041
    - Recruiting
    - The Second Affiliated Hospital of Shantou University Medical College-Cardiovascular
  - Shenzhen, Guangdong, China, 518020
    - Recruiting
    - ShenZhen People's Hospital
- Guangxi
  - Nanning, Guangxi, China, 530021
    - Recruiting
    - The People's Hospital of Guangxi Zhuang Autonomous Region
- Hainan
  - Haikou, Hainan, China, 570311
    - Recruiting
    - Hainan General Hospital
  - Haikou, Hainan, China, 570311
    - Not yet recruiting
    - Hainan General Hospital
- Hebei
  - Shijiazhuang, Hebei, China, 050051
    - Recruiting
    - Hebei General Hospital
  - Shijiazhuang, Hebei, China, 050023
    - Recruiting
    - The First Hospital of Hebei Medical University-Cardiovascular
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - Recruiting
    - The First Affiliated Hospital of Harbin Medical University-Cardiovascular
- Hubei
  - Wuhan, Hubei, China, 430060
    - Recruiting
    - Renmin Hospital of Wuhan University-Cardiology
  - Wuhan, Hubei, China, 430022
    - Recruiting
    - Wuhan Asia Heart Hospital-Department of Cardiovascular
- Hunan
  - Changsha, Hunan, China, 410013
    - Recruiting
    - The Third Xiangya Hospital of Central South University
  - Changsha, Hunan, China, 410028
    - Recruiting
    - Changsha Central Hospital
- Jiangsu
  - Changzhou, Jiangsu, China, 213004
    - Recruiting
    - The First People's Hospital of Changzhou
  - Changzhou, Jiangsu, China, 213003
    - Recruiting
    - Changzhou No.2 People's Hospital, Yanghu Branch
  - Huai'an, Jiangsu, China, 223300
    - Recruiting
    - Huai'an First People's Hospital, Nanjing Medical University
  - Nanjing, Jiangsu, China, 210011
    - Recruiting
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, Jiangsu, China, 210009
    - Completed
    - Zhongda Hospital Southeast University
  - Suzhou, Jiangsu, China, 215000
    - Recruiting
    - the First Affiliated Hospital of Soochow University
  - Suzhou, Jiangsu, China, 215000
    - Not yet recruiting
    - the First Affiliated Hospital of Soochow University
  - Xuzhou, Jiangsu, China, 221002
    - Not yet recruiting
    - The Affiliated Hospital of Xuzhou Medical University-Cardiology
  - Xuzhou, Jiangsu, China, 221002
    - Recruiting
    - The Affiliated Hospital of Xuzhou Medical University-Cardiology
  - Yangzhou, Jiangsu, China, 225001
    - Not yet recruiting
    - Northern Jiangsu People's Hospital
  - Yangzhou, Jiangsu, China, 225001
    - Recruiting
    - Northern Jiangsu People's Hospital
  - Zhenjiang, Jiangsu, China, 212001
    - Recruiting
    - The Affiliated Hospital of Jiangsu University
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - Recruiting
    - The Second Affiliated Hospital of Nanchang University-Cardiology
- Jilin
  - Changchun, Jilin, China, 130033
    - Recruiting
    - China-Japan Union Hospital of Jilin University-Cardiology
  - Changchun, Jilin, China, 130499
    - Recruiting
    - Jilin Province People's Hospital-Cardiology
  - Siping, Jilin, China, 136000
    - Recruiting
    - Siping Central People's Hospital-Cardiology
- Liaoning
  - Shenyang, Liaoning, China, 110016
    - Recruiting
    - The People's Hospital of Liaoning Province-Cardiology
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - Recruiting
    - General Hospital of Ningxia Medical University
- Shaanxi
  - Xi'an, Shaanxi, China, 710068
    - Recruiting
    - Shaanxi Provincial People's Hospital-Cardiology
  - Xi'an, Shaanxi, China, 710061
    - Completed
    - The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
- Shandong
  - Jining, Shandong, China, 272029
    - Recruiting
    - The Affiliated Hospital of Jining Medical University-Cardiology
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, China, 200031
    - Recruiting
    - Shanghai Xuhui Central Hospital
  - Shanghai, Shanghai Municipality, China, 200065
    - Recruiting
    - Tongji Hospital of Tongji University-Cardiology
  - Shanghai, Shanghai Municipality, China, 200040
    - Completed
    - Huashan Hospital Fudan University
- Sichuan
  - Mianyang, Sichuan, China, 621000
    - Recruiting
    - Mianyang Central Hospital-Cardiology
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300121
    - Recruiting
    - Tianjin Union Medical Center
  - Tianjin, Tianjin Municipality, China, 300222
    - Completed
    - Tianjin Chest Hospital
- Zhejiang
  - Hangzhou, Zhejiang, China, 310014
    - Recruiting
    - Zhejiang Provincial People's Hospital
  - Hangzhou, Zhejiang, China, 310003
    - Recruiting
    - The First Affiliated Hospital of Zhejiang University School of Medicine
  - Lishui, Zhejiang, China, 323000
    - Not yet recruiting
    - Lishui People's Hospital
  - Lishui, Zhejiang, China, 323000
    - Recruiting
    - Lishui People's Hospital-Cardiology
  - Wenzhou, Zhejiang, China, 325000
    - Completed
    - The First Affiliated Hospital of WMU-Cardiology
Colombia
- - Barranquilla, Colombia, 080020
    - Recruiting
    - Corazón IPS S.A.S
  - Barranquilla, Colombia, 080020
    - Not yet recruiting
    - Fundacion del Caribe para la Investigacion Biomedica-BIOS
  - Barranquilla, Colombia, 080020
    - Completed
    - Fundacion del Caribe para la Investigacion Biomedica-BIOS
  - Bogotá, Colombia, 110111
    - Not yet recruiting
    - Fundacion Santa Fe de Bogota
  - Medellín, Colombia, 050021
    - Recruiting
    - Promotora Medica Las Americas S.A.
  - Medellín, Colombia, 050034
    - Recruiting
    - CardiovidCentro Cardiovascular Colombiano ClinicaSantaMaria
- Antioquia
  - Medellín, Antioquia, Colombia, 050015
    - Recruiting
    - Hospital General de Medellin
  - Medellín, Antioquia, Colombia, 050015
    - Not yet recruiting
    - Hospital General de Medellin
  - Medellín, Antioquia, Colombia, 050021
    - Recruiting
    - Rodrigo Botero S.A.S
- Atlántico
  - Barranquilla, Atlántico, Colombia, 080001
    - Recruiting
    - IPS Centro Cientifico Asistencial Jose Luis Accini SAS
  - Barranquilla, Atlántico, Colombia, 80020
    - Recruiting
    - Clinica De La Costa
- Barranquilla
  - Soledad, Barranquilla, Colombia, 83001
    - Recruiting
    - Fundación Hospital Universidad del Norte
  - Soledad, Barranquilla, Colombia, 83001
    - Not yet recruiting
    - Fundación Hospital Universidad del Norte
- Caldas Department
  - Manizales, Caldas Department, Colombia, 170003
    - Recruiting
    - IPS médicos internistas de Caldas S.A.S.
- Cundinamarca
  - Chía, Cundinamarca, Colombia, 250001
    - Not yet recruiting
    - Centro de Atención e Investigación Médica S.A.S. (CAIMED SAS)
- Santander Department
  - Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, Colombia, 681012
    - Recruiting
    - Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760036
    - Recruiting
    - Clinica Imbanaco SAS
Croatia
- - Karlovac, Croatia, 47000
    - Not yet recruiting
    - Opca bolnica Karlovac
  - Karlovac, Croatia, 47000
    - Active, not recruiting
    - Opca bolnica Karlovac_Cardiology
  - Osijek, Croatia, 31 000
    - Active, not recruiting
    - Klinicki Bolnicki Centar Osijek_Cardiology
  - Rijeka, Croatia, 51000
    - Active, not recruiting
    - Specijalna Bolnica Medico
  - Rijeka, Croatia, 51000
    - Active, not recruiting
    - Clinical Hospital Centre Rijeka_Cardiology
  - Split, Croatia, 21 000
    - Active, not recruiting
    - KBC Split_Cardiology
  - Zagreb, Croatia, 10000
    - Completed
    - Poliklinika Magnolija d.o.o.
  - Zagreb, Croatia, 10 000
    - Completed
    - University Hospital Sveti Duh
  - Čakovec, Croatia, 40000
    - Completed
    - Poliklinika Medikol_Cakovec_Cardiology
  - Čakovec, Croatia, 40000
    - Completed
    - Zupanijska bolnica Cakovec
  - Čepin, Croatia, 31431
    - Active, not recruiting
    - Internacionalni medicinski centar PRIORA
- City of Zagreb
  - Zagreb, City of Zagreb, Croatia, 10000
    - Active, not recruiting
    - Poliklinika Solmed
  - Zagreb, City of Zagreb, Croatia, 10 000
    - Recruiting
    - University Hospital Centre Zagreb
  - Zagreb, City of Zagreb, Croatia, 10 000
    - Active, not recruiting
    - University Hospital Centre Zagreb
  - Zagreb, City of Zagreb, Croatia, 10000
    - Active, not recruiting
    - KB Dubrava, Zavod za bolesti srca i krvnih zila
  - Zagreb, City of Zagreb, Croatia, 10 000
    - Completed
    - Poliklinika Aritmija
- Krapinsko Zagorska County
  - Krapinske Toplice, Krapinsko Zagorska County, Croatia, 49217
    - Active, not recruiting
    - Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology
Czechia
- - Brno, Czechia, 602 00
    - Active, not recruiting
    - Kardiologie MUDr. Libor Nechvátal s.r.o.
  - Brno, Czechia, 639 00
    - Active, not recruiting
    - Amkardia s.r.o.
  - Hradec Králové, Czechia, 50005
    - Recruiting
    - FN Hradec Králové
  - Hradec Králové, Czechia, 50005
    - Completed
    - FN Hradec Králové
  - Liberec, Czechia, 460 02
    - Recruiting
    - KARDIOLOGIE - LIBEREC s.r.o.
  - Liberec, Czechia, 460 01
    - Recruiting
    - KARDIOLOGIE - LIBEREC s.r.o.
  - Plzen - Lochotín, Czechia, 323 00
    - Active, not recruiting
    - Fakultni nemocnice Plzen - Lochotin
  - Polička, Czechia, 572 01
    - Recruiting
    - Policska nemocnice
  - Polička, Czechia, 572 01
    - Active, not recruiting
    - Poličská nemocnice s.r.o.
  - Prague, Czechia, 110 00
    - Not yet recruiting
    - Kardiologická a interní ambulance
  - Prague, Czechia, 110 00
    - Active, not recruiting
    - Kardiologie Vinohrady s.r.o.
  - Prague, Czechia, 120 00
    - Recruiting
    - Fakultní poliklinika VFN ambulance Srdecniho selhani
  - Prague, Czechia, 120 00
    - Active, not recruiting
    - Fakultní poliklinika VFN ambulance Srdecniho selhani
  - Slaný, Czechia, 274 01
    - Not yet recruiting
    - Nemocnice Slany Kardiologie
  - Slaný, Czechia, 274 01
    - Active, not recruiting
    - Nemocnice Slany
  - Trutnov, Czechia, 541 01
    - Active, not recruiting
    - Kardiologie Trutnov Ferkl
  - Tábor, Czechia, 39003
    - Recruiting
    - Vseobecna kardiologicka ambulance
  - Tábor, Czechia, 39003
    - Not yet recruiting
    - Vseobecna kardiologicka ambulance
  - Tábor, Czechia, 39003
    - Active, not recruiting
    - Všeobecná kardiologická ambulance s.r.o.
  - Uherské Hradiště, Czechia, 68601
    - Active, not recruiting
    - Clinical Trials Service s.r.o.
  - Uherské Hradiště, Czechia, 68601
    - Not yet recruiting
    - Clinical Trials Service s.r.o.
Denmark
- - Aarhus N, Denmark, 8200
    - Recruiting
    - Aarhus Universitetshospital, Skejby Hjertesygdomme
  - Aarhus N, Denmark, 8200
    - Active, not recruiting
    - Aarhus Universitetshospital, Hjertesygdomme
  - Frederiksberg, Denmark, 2000
    - Active, not recruiting
    - Bispebjerg og Frederiksberg Hospital
  - Roskilde, Denmark, 4000
    - Active, not recruiting
    - Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling
- Capital Region
  - Herlev, Capital Region, Denmark, 2730
    - Active, not recruiting
    - Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1
- Region South
  - Svendborg, Region South, Denmark, 5700
    - Recruiting
    - Kardiologisk Odense & Svendborg
  - Svendborg, Region South, Denmark, 5700
    - Active, not recruiting
    - Svendborg Sygehus - Kardiologisk
Estonia
- - Tallinn, Estonia, 13419
    - Active, not recruiting
    - North Estonia Medical Centre Foundation
  - Tallinn, Estonia, 10138
    - Active, not recruiting
    - East Tallinn Central Hospital
  - Tartu, Estonia, 50406
    - Active, not recruiting
    - Tartu University Hospital
Finland
- - Helsinki, Finland, 00290
    - Active, not recruiting
    - HUS Cardiac and Lung Unit CRC
  - Jyväskylä, Finland, 40620
    - Active, not recruiting
    - StudyCor
  - Kuopio, Finland, 70600
    - Active, not recruiting
    - Health Step Finland Oy
  - Seinäjoki, Finland, 60220
    - Completed
    - Seinäjoen keskussairaala
  - Tampere, Finland, 33520
    - Active, not recruiting
    - TAYS Sydänsairaala
  - Turku, Finland, 20520
    - Active, not recruiting
    - TYKS Cardiac Unit
France
- - La Tronche, France, 38700
    - Active, not recruiting
    - Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon
  - Montpellier, France, 34295
    - Active, not recruiting
    - Hôpital Arnaud de Villeneuve_Service de Cardiologie
  - Paris, France, 75010
    - Active, not recruiting
    - Aphp-Hopital Lariboisiere
  - Paris, France, 75013
    - Active, not recruiting
    - APHP-HOPITAL LA PITIE SALPETRIERE_Institut de Cardiologie
  - Pau, France, 64000
    - Completed
    - Centre Hospitalier de Pau - Hôpital François Mitterrand
  - Poitiers, France, 86000
    - Not yet recruiting
    - Centre Hospitalier Universitaire De Poitiers
  - Poitiers, France, 86000
    - Active, not recruiting
    - CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS - Centre Cardio Vasculaire
  - Toulon, France, 83100
    - Active, not recruiting
    - Centre Hospitalier Intercommunal Toulon La Seine-Sur-Mer - Hopital Sainte Musse
  - Toulouse, France, 31059
    - Active, not recruiting
    - CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL_Service de Cardiologie
  - Vandœuvre-lès-Nancy, France, 54500
    - Not yet recruiting
    - Chru de Nancy - Hopital Brabois
Germany
- - Aachen, Germany, 52074
    - Active, not recruiting
    - Uniklinik Aachen - Med. Klinik I
  - Berlin, Germany, 13353
    - Not yet recruiting
    - Charite Universitatsmedizin Berlin KöR
  - Berlin, Germany, 10787
    - Completed
    - Velocity - Clinical Research Germany GmbH
  - Berlin, Germany, 13353
    - Active, not recruiting
    - Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)
  - Bielefeld, Germany, 33604
    - Completed
    - Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin
  - Bochum, Germany, 44791
    - Completed
    - Kath. Klinikum Bochum gGmbH - St. Josef-Hospital Kardiologie
  - Bremen, Germany, 28277
    - Recruiting
    - Kardiologisch-Angiologische Praxis Herzzentrum Bremen
  - Bremen, Germany, 28277
    - Active, not recruiting
    - Kardiologisch-Angiologische Praxis Herzzentrum Bremen
  - Dortmund, Germany, 44137
    - Active, not recruiting
    - Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie
  - Dresden, Germany, 01307
    - Active, not recruiting
    - Uniklinik TU Dresden - Herzzentrum Dresden GmbH
  - Dresden, Germany, 01099
    - Completed
    - Facharztzentrum Dresden Betriebsgesellschaft mbH
  - Dresden, Germany, 01277
    - Active, not recruiting
    - Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
  - Elsterwerda, Germany, 04910
    - Active, not recruiting
    - Zentrum fuer Klinische Studien Suedbrandenburg GmbH
  - Frankfurt, Germany, 60389
    - Active, not recruiting
    - MVZ CCB Frankfurt und Main-Taunus GbR
  - Frankfurt am Main, Germany, 60596
    - Active, not recruiting
    - Universitätsklinikum Frankfurt aM - Kardiologie
  - Freiburg im Breisgau, Germany, 79106
    - Active, not recruiting
    - Universitätsklinikum Freiburg - Medical Center
  - Giessen, Germany, 35392
    - Completed
    - Justus-Liebig-Universität Gießen - Kardiologie
  - Göttingen, Germany, 37075
    - Active, not recruiting
    - Uni-Med. Göttingen - Kardiologie, Pneumologie
  - Hamburg, Germany, 20251
    - Not yet recruiting
    - University Medical Center Hamburg-Eppendorf
  - Hamburg, Germany, 20246
    - Completed
    - Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf
  - Haßloch, Germany, 67454
    - Active, not recruiting
    - Kardiologie Haßloch
  - Homburg, Germany, 66421
    - Active, not recruiting
    - Universität des Saarlandes - Innere Med. III
  - Jena, Germany, 07747
    - Completed
    - Uniklinik Jena - Kardiologie
  - Kaiserslautern, Germany, 67655
    - Active, not recruiting
    - Kardiopraxis Schirmer
  - Leipzig, Germany, 04103
    - Completed
    - Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie
  - Mainz, Germany, 55116
    - Completed
    - Gesundheitscentrum Mainz (Regner / Schmitt)
  - Mannheim, Germany, 68165
    - Completed
    - zero PRAXEN Mannheim-Schwetzingerstadt
  - München, Germany, 81377
    - Completed
    - LMU Klinikum München Klinik und Poliklinik 1
  - Papenburg, Germany, 26871
    - Active, not recruiting
    - Kardiologische Gemeinschaftspraxis Papenburg
  - Rotenburg A.d. Fulda, Germany, 36199
    - Completed
    - Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg GmbH
  - Wermsdorf, Germany, 04779
    - Active, not recruiting
    - Al-Zoebi
  - Würzburg, Germany, 97078
    - Active, not recruiting
    - Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz
Greece
- - Ampelokipoi/Athens, Greece, 11522
    - Active, not recruiting
    - General Hospital of Athens "Elpis" - Cardiology Department
  - Athens, Greece, GR-11527
    - Not yet recruiting
    - Genl Hospital of Athens Ippokrateio,A' Cardiology Univ dpt
  - Athens, Greece, GR-15123
    - Recruiting
    - "Hygeia" General Hospital of Athens
  - Athens, Greece, 14233
    - Active, not recruiting
    - Konstantopouleio G.H. of Athens, "Agia Olga"
  - Athens, Greece, 15123
    - Active, not recruiting
    - "Hygeia" General Hospital of Athens
  - Athens, Greece, 11527
    - Active, not recruiting
    - Hippokration Hospital
  - Athens, Greece, 15125
    - Active, not recruiting
    - Iatriko Athinon (Athens Medical Canter)
  - Athens, Greece, 11527
    - Active, not recruiting
    - Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
  - Athens, Greece, 11527
    - Active, not recruiting
    - 'G. Gennimatas' General Hospital of Athens - Cardiology Department
  - Chaidari, Athens, Greece, 12462
    - Active, not recruiting
    - U.G.H of Athens "Attikon"
  - Chalcis, Greece, 34100
    - Completed
    - General Hospital of Kalamata - Cardiology Department
  - Chios, Greece, 82100
    - Active, not recruiting
    - General Hospital of Chios "Skilitsio" - Cardiology Clinic
  - Heraklion, Greece, 71409
    - Not yet recruiting
    - Venizeleio Pananeio
  - Heraklion, Greece, 71409
    - Completed
    - General Hospital Venizeleio-Pananeio - Cardiology department
  - Kalamata, Greece, 24100
    - Not yet recruiting
    - General Hospital of Kalamata
  - Kalamata, Greece, 24100
    - Completed
    - General Hospital of Kalamata - Cardiology Department
  - Kifissia, Greece, 14564
    - Completed
    - General Oncological Hospital of Kifissia Agioi Anargyroi - Cardiology Clinic
  - Larissa, Greece, 41110
    - Active, not recruiting
    - Univ Gen Hospital Larisa, Cardiology Medicine Clinic
  - Mytilene, Greece, 81132
    - Completed
    - General Hospital Of Mytilene Vostanio - Cardiology Department
  - Piraeus, Greece, 18536
    - Active, not recruiting
    - Geniko Nosokomeio Peiraia Tzaneio - Cardiology department
  - Pylea, Thessaloniki, Greece, 57001
    - Active, not recruiting
    - Iatriko Athinon (Athens Medical Canter)
  - Rio Patras, Greece, GR26504
    - Recruiting
    - General University Hospital of Patras
  - Rio Patras, Greece, 26504
    - Completed
    - General University Hospital of Patras
  - Thessaloniki, Greece, 54636
    - Not yet recruiting
    - "AHEPA" University General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54636
    - Active, not recruiting
    - "AHEPA" University General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54642
    - Completed
    - 'Ippokrateio' General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54636
    - Completed
    - "AHEPA" University General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54635
    - Completed
    - General Hospital of Thessaloniki 'G. Gennimatas - Cardiology Department
- Attica
  - Athens, Attica, Greece, 11528
    - Active, not recruiting
    - Alexandra General Hospital, Therapeutic Clinic
  - Athens, Attica, Greece, GR11528
    - Recruiting
    - Alexandra General Hospital, Therapeutic Clinic
- Crete
  - Heraklion, Crete, Greece, 71500
    - Completed
    - University General Hospital Of Heraklion - Cardiology Department
Hungary
- - Baja, Hungary, 6500
    - Recruiting
    - EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
  - Baja, Hungary, 6500
    - Active, not recruiting
    - EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
  - Balatonfüred, Hungary, 8230
    - Active, not recruiting
    - DRC Kft.
  - Balatonfüred, Hungary, 8230
    - Completed
    - Tagore Medical Center
  - Budapest, Hungary, 1204
    - Active, not recruiting
    - Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Budapest, Hungary, 1096
    - Completed
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Hungary, 1122
    - Active, not recruiting
    - Semmelweis Egyetem Városmajori Szív- és Érgyógyászat
  - Budapest, Hungary, 1023
    - Completed
    - Betegápoló Irgalmasrend, Budai Irgalmasrendi Kórház
  - Budapest, Hungary, 1134
    - Completed
    - Észak-Pesti Centrumkórház Honvédkórház
  - Gyula, Hungary, 5700
    - Not yet recruiting
    - Békés Vármegyei Központi Kórház
  - Gyula, Hungary, 5700
    - Completed
    - Békés Vármegyei Központi Kórház
  - Miskolc, Hungary, 3526
    - Completed
    - Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
  - Pécs, Hungary, 7623
    - Active, not recruiting
    - Coromed SMO Kft.
  - Szeged, Hungary, 6725
    - Completed
    - Szegedi Tudomanyegyetem
- Baranya
  - Pécs, Baranya, Hungary, 7624
    - Recruiting
    - PTE ÁOK I. sz. Belgyógyászati Klinika
  - Pécs, Baranya, Hungary, 7624
    - Active, not recruiting
    - PTE ÁOK I. sz. Belgyógyászati Klinika
- Bekes County
  - Békéscsaba, Bekes County, Hungary, 5600
    - Active, not recruiting
    - Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
  - Orosháza, Bekes County, Hungary, 5900
    - Active, not recruiting
    - Arina Trial Research kft.
- Bács-Kiskun county
  - Baja, Bács-Kiskun county, Hungary, 6500
    - Active, not recruiting
    - Lausmed Kft.
- Csongrád-Csanád
  - Szeged, Csongrád-Csanád, Hungary, 6725
    - Active, not recruiting
    - Szegedi Tudományegyetem II. sz Belgyógyászati és Kardiológia
- Komárom-Esztergom
  - Komárom, Komárom-Esztergom, Hungary, 2921
    - Active, not recruiting
    - Selye János Kórház
- Somogy County
  - Kaposvár, Somogy County, Hungary, 7400
    - Active, not recruiting
    - Somogy Megyei Kaposi Mor Oktato Korhaz
- Zala County
  - Zalaegerszeg, Zala County, Hungary, 8900
    - Active, not recruiting
    - Léda Platán Magánklinika
India
- - Aligarh, India, 202002
    - Completed
    - Aligarh Muslim University
  - Bengaluru, India, 560054
    - Not yet recruiting
    - MS Ramaiah
  - Bengaluru, India, 560054
    - Completed
    - MS Ramaiah
  - Karnataka, India, 590010
    - Recruiting
    - KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre
  - New Delhi, India, 110060
    - Recruiting
    - Sir Ganga Ram Hospital-Cardiology
  - New Delhi, India, 110055
    - Completed
    - Dr B L Kapur Memorial Hospital
  - New Delhi, India, 110075
    - Completed
    - Aakash Healthcare Super Speciality Hospital
  - Palakkad, India, 678013
    - Recruiting
    - Lakshmi Hospital
  - Puducherry, India, 605006
    - Completed
    - JIPMER
- Andhra Pradesh
  - Guntur, Andhra Pradesh, India, 522001
    - Not yet recruiting
    - Lalitha Super Specialities Hospital
  - Guntur, Andhra Pradesh, India, 522001
    - Recruiting
    - Lalitha PVS Institute of Medical Sciences
  - Vijayawada, Andhra Pradesh, India, 520008
    - Recruiting
    - Ramesh Hospitals
  - Vijaywada, Andhra Pradesh, India, 520008
    - Recruiting
    - Siddhartha Medical College & Government General Hospital
- Assam
  - Guwahati, Assam, India, 781006
    - Completed
    - GNRC Hospital
- Gujarat
  - Ahmedabad, Gujarat, India, 380060
    - Recruiting
    - CIMS- Care Institute of Medical Sciences
  - Ahmedabad, Gujarat, India, 380060
    - Recruiting
    - Epic Hospital
  - Ahmedabad, Gujarat, India, 38006
    - Recruiting
    - Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
  - Ahmedabad, Gujarat, India, 380006
    - Recruiting
    - Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
  - Surat, Gujarat, India, 395002
    - Recruiting
    - Nirmal Hospital Pvt. Ltd.
  - Surat, Gujarat, India, 395001
    - Recruiting
    - Shri B. D. Mehta Mahavir Heart Institute
  - Surat, Gujarat, India, 395001
    - Completed
    - Shri B. D. Mehta Mahavir Heart Institute
  - Vadodara, Gujarat, India, 390022
    - Recruiting
    - Rhythm Heart Institute
- Haryana
  - Gurugram, Haryana, India, 122001
    - Recruiting
    - Medanta - The Medicity Multi-Speciality Hospital, Gurugram
- Karnataka
  - Bangalore, Karnataka, India, 560017
    - Completed
    - Manipal Hospital, Old Airport Road, Bengaluru
  - Belagavi, Karnataka, India, 590010
    - Recruiting
    - KLES Dr. Prabhakar Kore Hospital & Medical Research Centre
  - Bengaluru, Karnataka, India, 560069
    - Not yet recruiting
    - Sri Jayadeva Institute of Cardiovascular Sciences & Research
  - Bengaluru, Karnataka, India, 560069
    - Recruiting
    - Sri Jayadeva Institute of Cardiovascular Sciences & Research
  - Bengaluru, Karnataka, India, 560099
    - Completed
    - Narayana Institute of Cardiac Sciences
- Kerala
  - Kochi, Kerala, India, 682041
    - Recruiting
    - Amrita Institute of Medical Sciences
  - Kochi, Kerala, India, 682018
    - Recruiting
    - Lisie Hospital
  - Kozhikode, Kerala, India, 673008
    - Completed
    - Government Medical College, Kozhikode
- Maharashtra
  - Mumbai, Maharashtra, India, 400012
    - Completed
    - Seth GS medical college and KEM Hospital
  - Nagpur, Maharashtra, India, 440010
    - Recruiting
    - Arneja Heart & Multispeciality Hospital
  - Nagpur, Maharashtra, India, 440012
    - Not yet recruiting
    - Shri Krishna Hrudayalaya & Critical Care Centre
  - Nagpur, Maharashtra, India, 440033
    - Not yet recruiting
    - Sengupta Hospital and Research Institute
  - Nagpur, Maharashtra, India, 440012
    - Recruiting
    - Shri Krishna Hrudayalaya & Critical Care Centre
  - Nagpur, Maharashtra, India, 440033
    - Recruiting
    - Sengupta Hospital and Research Institute
  - Nagpur, Maharashtra, India, 440003
    - Completed
    - Government Medical College and Super Speciality Hospital, Nagpur
  - Pune, Maharashtra, India, 411011
    - Recruiting
    - KEM Hospital
  - Pune, Maharashtra, India, 411004
    - Recruiting
    - Sahyadri Clinical Research And Development Center
  - Pune, Maharashtra, India, 411001
    - Completed
    - B J Goverment Medical College and Sassoon General Hospital
  - Pune, Maharashtra, India, 411001
    - Completed
    - Jehangir Clinical Development Centre
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110029
    - Recruiting
    - All India Institute Of Medical Sciences (AIIMS)
  - New Delhi, National Capital Territory of Delhi, India, 110002
    - Recruiting
    - G B Pant Institute of Postgraduate Medical Education and Research
  - New Delhi, National Capital Territory of Delhi, India, 110025
    - Completed
    - Fortis Escorts Heart Institute, New Delhi
- New Delhi
  - New Dehli, New Delhi, India, 110029
    - Recruiting
    - VMMC & Safdarjung Hospital
- Punjab
  - Chandigarh, Punjab, India, 160012
    - Completed
    - Post Graduate Institute of Medical Education & Research_Chandigarh
  - Ludhiana, Punjab, India, 141001
    - Recruiting
    - Dayanand Medical College & Hospital
  - Ludhiana, Punjab, India, 141002
    - Recruiting
    - Deep Hospital
  - Mohali, Punjab, India, 160062
    - Recruiting
    - Fortis Hospital, Mohali
- Rajasthan
  - Bikaner, Rajasthan, India, 334003
    - Not yet recruiting
    - S.P. Medical College and A.G. Hospitals
  - Bikaner, Rajasthan, India, 334003
    - Recruiting
    - S.P. Medical College and A.G. Hospitals
  - Jaipur, Rajasthan, India, 302004
    - Recruiting
    - SMS Medical College & Attached Hospitals
  - Jaipur, Rajasthan, India, 302001
    - Recruiting
    - SMS Medical College & Attached Hospitals
  - Jodhpur, Rajasthan, India, 342005
    - Recruiting
    - All India Institute of Medical Sciences (AIIMS), Jodhpur
  - Jodhpur, Rajasthan, India, 342005
    - Completed
    - All India Institute Of Medical Sciences (AIIMS)
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600037
    - Recruiting
    - The Madras Medical Mission
- Telangana
  - Hyderabad, Telangana, India, 500032
    - Not yet recruiting
    - AIG Hospitals,Hyderabad
  - Hyderabad, Telangana, India, 500020
    - Not yet recruiting
    - Guru Nanak CARE Hospitals
  - Hyderabad, Telangana, India, 500020
    - Recruiting
    - Guru Nanak CARE Hospitals
  - Hyderabad, Telangana, India, 500012
    - Active, not recruiting
    - Osmania General Hospital
  - Hyderabad, Telangana, India, 500 012
    - Recruiting
    - Osmania General Hospital
  - Hyderabad, Telangana, India, 500032
    - Completed
    - AIG Hospitals,Hyderabad
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226003
    - Not yet recruiting
    - King George's Medical University (KGMU)
  - Lucknow, Uttar Pradesh, India, 226003
    - Recruiting
    - King George's Medical University (KGMU)
- Uttarakhand
  - Dehradun, Uttarakhand, India, 248001
    - Recruiting
    - Shri Mahant Indiresh Hospital
- West Bengal
  - Kolkata, West Bengal, India, 700020
    - Completed
    - IPGME&R and SSKM Hospital
Ireland
- - Cork, Ireland, T12 DC4A
    - Completed
    - Cork University Hospital
  - Dublin, Ireland, D07KWR1
    - Active, not recruiting
    - Mater Private Network - Dublin
  - Dublin, Ireland, A96 D628
    - Active, not recruiting
    - The Heartbeat Trust
  - Dublin, Ireland, D07 KX5K
    - Completed
    - Mater Miscericordiae Hospital
  - Dublin, Ireland, D08 A978
    - Completed
    - St James's CRF
  - Mahon, Cork, Ireland, T12 K199
    - Completed
    - Mater Private Network Cork
- Leinster
  - Dublin, Leinster, Ireland, D08 A978
    - Completed
    - St James's CRF
Israel
- - Beer Yaakov, Israel, 7033001
    - Active, not recruiting
    - Shamir MC - Cardiology Department
  - Hadera, Israel, 3810101
    - Active, not recruiting
    - Hillel Yafe MC - Cardiology Department
  - Haifa, Israel, 3109601
    - Active, not recruiting
    - Rambam MC - Heart Failure Unit
  - Jerusalem, Israel, 91120
    - Active, not recruiting
    - Hadassah Ein Karam MC - Cardio Department
  - Petah Tikva, Israel, 49100
    - Active, not recruiting
    - Rabin MC Beilinson - Heart Failure Unit
  - Rehovot, Israel, 76100
    - Active, not recruiting
    - Kaplan MC - Heart Failure Unit
  - Tel Aviv, Israel, 6423906
    - Active, not recruiting
    - Sourasky MC - Cardio Vascular Research Center
  - Tel Litwinsky, Israel, 5265601
    - Completed
    - Sheba MC - Cardiology Clinical Research Unit
Italy
- - Bari, Italy, 70124
    - Active, not recruiting
    - Fondazione Salvatore Maugeri I.R.C.C.S. - Bari
  - Foggia, Italy, 71122
    - Recruiting
    - Ospedali Riuniti di Foggia
  - Foggia, Italy, 71122
    - Active, not recruiting
    - Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia
  - Grosseto, Italy, 58100
    - Active, not recruiting
    - AUSL Toscana Sud Est - Ospedale Misericordia Grosseto
  - Milan, Italy, 20157
    - Not yet recruiting
    - ASST Fatebenefratelli Ospedale Luigi Sacco Medicina Interna
  - Milan, Italy, 20157
    - Active, not recruiting
    - ASST Fatebenefratelli Ospedale Luigi Sacco Medicina Interna
  - Monza, Italy, 20900
    - Active, not recruiting
    - Azienda Ospedaliera San Gerardo
  - Napoli, Italy, 80131
    - Not yet recruiting
    - Azienda Ospedaliera di Rilievo Nazionale AORN Dei Colli, "V.Monaldi",
  - Napoli, Italy, 80131
    - Completed
    - Azienda Ospedaliera Dei Colli - Monaldi - Centro ricerche cardiologiche
  - Novara, Italy, 28100
    - Active, not recruiting
    - AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia
  - Pavia, Italy, 27100
    - Not yet recruiting
    - Fondazione IRCCS Policlinico San Matteo
  - Pavia, Italy, 27100
    - Active, not recruiting
    - Fondazione IRCCS Policlinico San Matteo
  - Trieste, Italy, 34128
    - Not yet recruiting
    - Azienda Sanitaria Univ Giuliano Isontina
  - Trieste, Italy, 34128
    - Completed
    - Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia
- Al
  - Casale Monferrato, Al, Italy, 15033
    - Recruiting
    - Ospedale Santo Spirito
  - Casale Monferrato, Al, Italy, 15033
    - Active, not recruiting
    - ASL Al Di Alessandria - Ospedale Santo Spirito - Casale Monferrato - Cardiologia
- Bg
  - Bergamo, Bg, Italy, 24127
    - Recruiting
    - Asst Papa Giovanni XXIII
- Bn
  - Benevento, Bn, Italy, 82100
    - Not yet recruiting
    - AORN "San Pio"- Benevento
  - Benevento, Bn, Italy, 82100
    - Completed
    - AORN "San Pio"- Benevento - UOC Cardiologia Interventistica ed UTIC
- Bs
  - Brescia, Bs, Italy, 25123
    - Recruiting
    - Spedali Civili Brescia
  - Brescia, Bs, Italy, 25123
    - Active, not recruiting
    - Spedali Civili Brescia
- Ce
  - Caserta, Ce, Italy, 81100
    - Not yet recruiting
    - AORN "Sant'Anna e San Sebastiano"
  - Caserta, Ce, Italy, 81100
    - Completed
    - AORN "Sant'Anna e San Sebastiano"
- Cz
  - Catanzaro, Cz, Italy, 88100
    - Recruiting
    - Azienda Ospedaliero-Universitaria Renato Dulbecco
  - Catanzaro, Cz, Italy, 88100
    - Active, not recruiting
    - Azienda Ospedaliero-Universitaria Renato Dulbecco
- Fe
  - Cona (Ferrara), Fe, Italy, 44124
    - Not yet recruiting
    - A.O.U. Ferrara, Sant'Anna
  - Cona (Ferrara), Fe, Italy, 44124
    - Active, not recruiting
    - A.O.U. Ferrara, Sant'Anna
- Ge
  - Genova, Ge, Italy, 16132
    - Recruiting
    - IRCCS Ospedale Policlinico San Martino
  - Genova, Ge, Italy, 16132
    - Active, not recruiting
    - IRCCS Ospedale Policlinico San Martino
- Lombardy
  - Bergamo, Lombardy, Italy, 24127
    - Active, not recruiting
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
- Pg
  - Perugia, Pg, Italy, 06129
    - Active, not recruiting
    - Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia
- Pi
  - Pisa, Pi, Italy, 56126
    - Recruiting
    - Fondazione CNR-Regione Toscana Gabriele Monasterio
  - Pisa, Pi, Italy, 56124
    - Active, not recruiting
    - Fondazione Toscana Gabriele Monasterio - Dipartimento Cardiotoracico - UOC Cardiologia e Medicina Cardiovascolare
- Rm
  - Roma, Rm, Italy, 00135
    - Completed
    - Azienda Sanitaria Locale Roma 1 - Ospedale San Filippo Neri - Cardiologia Clinica
- Si
  - Siena, Si, Italy, 53100
    - Recruiting
    - Azienda Ospedaliera Universitaria Senese
  - Siena, Si, Italy, 53100
    - Active, not recruiting
    - Azienda Ospedaliera Universitaria Senese
- To
  - Rivoli, To, Italy, 10098
    - Recruiting
    - Presidio Ospedaliero di Rivoli
  - Rivoli, To, Italy, 10098
    - Active, not recruiting
    - Presidio Ospedaliero di Rivoli
  - Torino, To, Italy, 10128
    - Not yet recruiting
    - Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia
  - Torino, To, Italy, 10128
    - Active, not recruiting
    - Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia
- Veneto
  - Treviso, Veneto, Italy, 31100
    - Not yet recruiting
    - Ospedale Ca' Foncello
- Vr
  - Verona, Vr, Italy, 37126
    - Not yet recruiting
    - AOUI Verona
  - Verona, Vr, Italy, 37126
    - Active, not recruiting
    - AOUI Verona
Japan
- - Bunkyo-ku, Tokyo, Japan, 113-8655
    - Recruiting
    - The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
  - Fukuoka, Japan, 810-8539
    - Recruiting
    - Hamanomachi Hospital_Cardiovascular medicine
  - Fukuoka, Japan, 812-8582
    - Not yet recruiting
    - Kyushu University Hospital_Cardiovascular Medicine
  - Fukuoka, Japan, 812-8582
    - Recruiting
    - Kyushu University Hospital_Cardiovascular Medicine
  - Fukuoka-shi, Fukuoka, Japan, 814-0133
    - Recruiting
    - Fukuoka University Hospital_Cardiology
  - Gifu, Japan, 503-8502
    - Recruiting
    - Ogaki Municipal Hospital_Cardiology
  - Hamamatsu-shi, Shizuoka, Japan, 430-0929
    - Recruiting
    - JA Shizuoka Kohseiren Enshu Hospital_ cardiology
  - Himeji-shi, Hyogo, Japan, 670-8560
    - Recruiting
    - Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
  - Hokkaido, Japan, 078-8211
    - Recruiting
    - Asahikawa-Kosei General Hospital_Cardiology
  - Hyōgo, Japan, 665-0125
    - Recruiting
    - Veritas Hospital_Cardiology
  - Ibaraki, Japan, 311-3193
    - Recruiting
    - National Hospital Organization Mito Medical Center_Cardiovascular medicine
  - Imabari-shi, Ehime, Japan, 799-1592
    - Recruiting
    - Saiseikai Imabari Hospital
  - Imabari-shi, Ehime, Japan, 799-1592
    - Recruiting
    - Saiseikai Imabari Hospital_Cardiology
  - Ishikawa, Japan, 920-8530
    - Recruiting
    - Ishikawa Prefectural Central Hospital_Cardiology
  - Kagawa, Japan, 769-1695
    - Recruiting
    - Mitoyo General Hospital_Cardiovascular medicine
  - Kagoshima, Japan, 890-8760
    - Recruiting
    - Kagoshima City Hospital_Cardiovascular Medicine
  - Kanagawa, Japan, 236-0051
    - Not yet recruiting
    - Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center_Cardiology
  - Kanagawa, Japan, 236-0037
    - Recruiting
    - Yokohama Minami Kyousai Hospital_Cardiology
  - Kanagawa, Japan, 259-1193
    - Recruiting
    - Tokai University Hospital_Cardiology
  - Kanagawa, Japan, 236-0051
    - Completed
    - Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center_Cardiology
  - Kishiwada-shi, Osaka, Japan, 596-0042
    - Recruiting
    - Kishiwada Tokushukai Hospital_Cardiology
  - Kitakyushu-shi, Fukuoka, Japan, 806-8501
    - Recruiting
    - Japan Community Health care Organization Kyushu Hospital_Cardiology
  - Kitakyushu-shi, Fukuoka, Japan, 806-8501
    - Recruiting
    - JCHO Kyushu Hospital_Cardiology
  - Kyoto, Japan, 604-8401
    - Recruiting
    - Rakuwakai Marutamachi Hospital_Cardiology
  - Kyoto, Japan, 606-8507
    - Recruiting
    - Kyoto University Hospital_Cardiovascular Medicine
  - Mie, Japan, 510-8561
    - Recruiting
    - Mie Prefectural General Medical Center_Cardiology
  - Miyagi, Japan, 980-0803
    - Recruiting
    - KKR Tohoku Kosai Hospital_Cardiology
  - Miyagi, Japan, 983-8512
    - Recruiting
    - Tohoku Medical and Pharmaceutical University Hospital_Division of Cardiology
  - Miyagi, Japan, 983-8520
    - Recruiting
    - National Hospital Organization Sendai Medical Center_Cardiovascular medicine
  - Morioka-shi, Iwate, Japan, 020-0066
    - Recruiting
    - Iwate Prefectural Central Hospital
  - Morioka-shi, Iwate, Japan, 020-0066
    - Recruiting
    - Iwate Prefectural Central Hospital_Cardiology
  - Nagasaki, Japan, 850-8555
    - Recruiting
    - Nagasaki Harbor Medical Center_Cardiovascular medicine
  - Okayama, Japan, 700-8557
    - Recruiting
    - Okayama City General Medical Center Okayama City Hospital_Cardiovascular Medicine
  - Okayama, Japan, 701-1154
    - Recruiting
    - Okayama Medical Center_Cardiology
  - Okayama-shi, Okayama, Japan, 700-8558
    - Not yet recruiting
    - Okayama University Hospital_Cardiovascular Medicine
  - Okayama-shi, Okayama, Japan, 700-8558
    - Completed
    - Okayama University Hospital_Cardiovascular Medicine
  - Osaka, Japan, 540-0006
    - Recruiting
    - National Hospital Organization Osaka National Hospital_Cardiovascular Division
  - Osaka, Japan, 565-0871
    - Recruiting
    - Osaka University Hospital_Cardiovascular medicine
  - Osaka, Japan, 564-8565
    - Recruiting
    - National Cerebral and Cardiovascular Center Hospital_Department of Heart Failure
  - Osaka, Japan, 565-0871
    - Recruiting
    - The University of Osaka Hospital_Cardiovascular medicine
  - Osaka, Japan, 581-0011
    - Recruiting
    - Yao Tokushukai General Hospital_Cardiovascular division
  - Osaka, Japan, 564-0013
    - Completed
    - Saiseikai Suita Hospital_Cardiovascular Medicine
  - Saga, Japan, 840-8571
    - Completed
    - Saga-ken Medical Centre Koseikan_Cardiology
  - Shizuoka, Japan, 436-8555
    - Recruiting
    - Chutoen General Medical Center_Cardiology
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Recruiting
    - Kagawa Prefectural Central Hospital_Cardiovascular Medicine
  - Tokyo, Japan, 113-8431
    - Recruiting
    - Juntendo University Hospital_Cardiology
  - Tokyo, Japan, 160-8582
    - Recruiting
    - Keio University Hospital_Cardiology
  - Tokyo, Japan, 140-8522
    - Recruiting
    - Tokyo Shinagawa Hospital_Cardiovascular Medicine
  - Tokyo, Japan, 103-0027
    - Recruiting
    - Tokyo-Eki Center-building Clinic_Internal Medicine
  - Tottori, Japan, 683-8504
    - Recruiting
    - Tottori University Hospital_Cardiovascular Medicine
  - Tottori, Japan, 683-8504
    - Active, not recruiting
    - Tottori University Hospital
  - Toyama, Japan, 930-0194
    - Recruiting
    - Toyama University Hospital_Internal Medicine 2
  - Yamaguchi, Japan, 740-8510
    - Recruiting
    - National Hospital Organization Iwakuni Clinical Center_Cardiovascular Medicine
  - Yamaguchi, Japan, 745-8522
    - Recruiting
    - JCHO Tokuyama Community Health Center_Department of Cardiology
  - Yokohama-shi, Kanagawa, Japan, 234-0054
    - Completed
    - Saiseikai Yokohamashi Nanbu Hospital_Cardiology
- Ehime
  - Uwajima-shi, Ehime, Japan, 798-8510
    - Recruiting
    - Uwajima City Hospital_Cardiology
- Kanagawa
  - Yokohama, Kanagawa, Japan, 227-8501
    - Recruiting
    - Showa University Fujigaoka Hospital_Cardiology
Latvia
- - Jelgava, Latvia, 3001
    - Active, not recruiting
    - Zemgales diabetes centre
  - Riga, Latvia, 1001
    - Active, not recruiting
    - Riga 1st Hospital
  - Riga, Latvia, 1002
    - Active, not recruiting
    - P. Stradins Clinical University hospital
  - Riga, Latvia, 1011
    - Active, not recruiting
    - Adoria
  - Riga, Latvia, 1023
    - Active, not recruiting
    - GK Neiroklinika
  - Riga, Latvia, 1013
    - Active, not recruiting
    - Professor Skride Heart Clinic
  - Riga, Latvia, 1079
    - Completed
    - Riga East Clinical University Hospital - Clinic "Gailezers"
  - Riga, Latvia, 1039
    - Not yet recruiting
    - Veselibas centru apvieniba
- South Kurzeme Municipality
  - Grobiņa, South Kurzeme Municipality, Latvia, 3430
    - Active, not recruiting
    - Zane Lucane GP Practice
Lithuania
- - Kaunas, Lithuania, 50161
    - Completed
    - Hospital of Lithuanian University of Health Sciences Kauno klinikos
  - Kaunas, Lithuania, 49449
    - Active, not recruiting
    - JSC "Saules seimos medicinos centras"
  - Kaunas, Lithuania, 45130
    - Active, not recruiting
    - Kaunas Hospital of the Lithuanian University of Health Sciences
  - Kaunas, Lithuania, 49387
    - Active, not recruiting
    - Klinikiniai sprendimai, Kaunas
  - Klaipėda, Lithuania, LT-92288
    - Recruiting
    - Klaipeda University Hospital
  - Klaipėda, Lithuania, 92288
    - Active, not recruiting
    - Klaipeda University Hospital
  - Klaipėda, Lithuania, 91131
    - Completed
    - Cardiology and Rehabilitation Clinic
  - Vilnius, Lithuania, 08661
    - Active, not recruiting
    - Vilnius University Hospital Santaros Klinikos
  - Vilnius, Lithuania, 08406
    - Completed
    - JSC Inlita Santaros
  - Šiauliai, Lithuania, 76206
    - Completed
    - Republican Siauliai Hospital Consulting Outpatient Clinic
Malaysia
- - Kajang, Malaysia, 43000
    - Not yet recruiting
    - Hospital Serdang
  - Kuala Lumpur, Malaysia, 50586
    - Recruiting
    - Hospital Kuala Lumpur
- Johor
  - Johor Bahru, Johor, Malaysia, 80100
    - Recruiting
    - Hospital Sultanah Aminah
  - Johor Bahru, Johor, Malaysia, 80100
    - Not yet recruiting
    - Hospital Sultanah Aminah
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Recruiting
    - Hospital Sultanah Bahiyah
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Active, not recruiting
    - Hospital Universiti Sains Malaysia
- Kuala Lumpur
  - Cheras, Kuala Lumpur, Malaysia, 56000
    - Not yet recruiting
    - Hospital Universiti Kebangsaan Malaysia
  - Cheras, Kuala Lumpur, Malaysia, 56000
    - Active, not recruiting
    - Hospital Canselor Tuanku Muhriz UKM
  - Lembah Pantai, Kuala Lumpur, Malaysia, 59100
    - Recruiting
    - University Malaya Medical Centre
- Pahang
  - Kuantan, Pahang, Malaysia, 25100
    - Recruiting
    - Hospital Tengku Ampuan Afzan
- Sarawak
  - Kota Samarahan, Sarawak, Malaysia, 94300
    - Recruiting
    - Sarawak Heart Centre
- Selangor
  - Kajang, Selangor, Malaysia, 43000
    - Recruiting
    - Hospital Serdang
  - Sungai Buloh, Selangor, Malaysia, 47000
    - Recruiting
    - Universiti Teknologi MARA, Sungai Buloh Campus
Mexico
- - Mexico City, Mexico, 03100
    - Not yet recruiting
    - Centro de Investigación Biomédica y Farmacéutica S.C.
  - México, Mexico, 10700
    - Recruiting
    - Centro de Imagen y Tecnologia en Intervención Cardiovascular
- Aguascalientes
  - Aguascalientes, Aguascalientes, Mexico, 20230
    - Recruiting
    - Hospital Cardiologica Aguascalientes
  - Aguascalientes, Aguascalientes, Mexico, 20230
    - Not yet recruiting
    - Hospital Cardiologica Aguascalientes
- Estado de Baja California
  - Tijuana, Estado de Baja California, Mexico, 22500
    - Recruiting
    - CINCAME
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44130
    - Recruiting
    - Diseño y Planeacion en Investigacion Medica S.C.
- México, D.F.
  - Mexico City, México, D.F., Mexico, 14080
    - Completed
    - Instituto Nacional de Cardiologia Ignacio Chavez
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64718
    - Recruiting
    - Eukarya Pharmasite S.C.
  - Monterrey, Nuevo León, Mexico, 64020
    - Recruiting
    - Internal Medicine Clin Trials
  - Monterrey, Nuevo León, Mexico, 64060
    - Recruiting
    - Cardiolink Clin Trials S.C.
  - Monterrey, Nuevo León, Mexico, 64060
    - Not yet recruiting
    - Cardiolink Clin Trials S.C.
  - San Nicolás de los Garza, Nuevo León, Mexico, 66465
    - Recruiting
    - Centro de Investigación y Control Metabólico S. C.
- Querétaro
  - Santiago de Querétaro, Qro., Querétaro, Mexico, 76000
    - Recruiting
    - Centro de Estudios Clínicos de Querétaro S.C.
- San Luis Potosí
  - San Luis Potosí City, San Luis Potosí, Mexico, 78200
    - Recruiting
    - Centro de Atención e Investigación Cardiovascular del Potosí
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Recruiting
    - Centro para el Desarrollo de la Medicina y la Asistencia
  - Culiacán, Sinaloa, Mexico, 80230
    - Recruiting
    - Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
- Veracruz
  - Xalapa, Veracruz, Mexico, 91193
    - Recruiting
    - Hospital Angeles de Xalapa
  - Xalapa, Veracruz, Mexico, 91193
    - Not yet recruiting
    - Hospital Angeles de Xalapa
Netherlands
- - Amsterdam, Netherlands, 1091 AC
    - Active, not recruiting
    - OLVG Oost
  - Deventer, Netherlands, 7416 SE
    - Active, not recruiting
    - Deventer Ziekenhuis - Cardiologie
  - Dordrecht, Netherlands, 3318 AT
    - Active, not recruiting
    - Albert Schweitzer Zkh, Dordwijk
  - Emmen, Netherlands, 7824 AA
    - Active, not recruiting
    - Treant, Scheper - Cardiologie
  - Enschede, Netherlands, 7512 KZ
    - Active, not recruiting
    - Medisch Spectrum Twente - Cardiologie
  - Groningen, Netherlands, 9713 GZ
    - Active, not recruiting
    - UMC Groningen - Cardiologie
  - Heerlen, Netherlands, 6419 PC
    - Active, not recruiting
    - Zuyderland ziekenhuis - Cardiologie
  - Maastricht, Netherlands, 6229 HX
    - Active, not recruiting
    - Maastricht Universitair Medisch Centrum
  - Nijmegen, Netherlands, 6525 GA
    - Completed
    - Radboudumc
  - Rotterdam, Netherlands, 3015 GD
    - Active, not recruiting
    - Erasmus MC
  - The Hague, Netherlands, 2545AA
    - Active, not recruiting
    - HagaZiekenhuis
North Macedonia
- - Skopje, North Macedonia, 1000
    - Active, not recruiting
    - PHI City General Hospital 8th September
  - Skopje, North Macedonia, 1000
    - Active, not recruiting
    - PHI University Clinic for Cardiology
  - Skopje, North Macedonia, 1000
    - Active, not recruiting
    - Private Healthcare Institution - Acibadem Sistina Hospital Skopje
  - Skopje, North Macedonia, 1000
    - Completed
    - PHI University Clinic for Cardiology
Norway
- - Bergen, Norway, 5021
    - Active, not recruiting
    - Haukeland Universitetssykehus
  - Lørenskog, Norway, 1478
    - Active, not recruiting
    - Akershus Universitetssykehus Hf
  - Oslo, Norway, 0450
    - Active, not recruiting
    - Oslo universitetssykehus HF - Ullevål
  - Oslo, Norway, 0369
    - Active, not recruiting
    - Colosseumklinikken Medisinske Senter AS
  - Oslo, Norway, 0372
    - Active, not recruiting
    - Rikshospitalet - Kardiologisk forskning
  - Stavanger, Norway, NO-4011
    - Active, not recruiting
    - Stavanger Universitetssykehus, Helse Stavanger HF
Poland
- - Bełchatów, Poland, 97-400
    - Not yet recruiting
    - American Heart of Poland S.A.
  - Gliwice, Poland, 44-100
    - Completed
    - Szpital Miejski w Gliwicach Sp. z o.o.
  - Katowice, Poland, 40-568
    - Not yet recruiting
    - Care Clinic Sp. z o. o.
  - Katowice, Poland, 40-600
    - Not yet recruiting
    - Gyncentrum Sp. z o. o.
  - Katowice, Poland, 40-748
    - Not yet recruiting
    - Vita Longa Sp. z o. o.
  - Katowice, Poland, 40-568
    - Active, not recruiting
    - Care Clinic Sp. z o. o.
  - Katowice, Poland, 40-748
    - Active, not recruiting
    - Vita Longa Sp. z o. o.
  - Katowice, Poland, 40-555
    - Completed
    - Kardio Brynow Sp. z o. o.
  - Katowice, Poland, 40-600
    - Active, not recruiting
    - Gyncentrum Sp. z o. o.
  - Kluczbork, Poland, 46-200
    - Completed
    - SCANMED Spółka Akcyjna
  - Krakow, Poland, 30-082
    - Completed
    - Specjalistyczna Praktyka Lekarska L. Bryniarski
  - Krakow, Poland, 31-271
    - Active, not recruiting
    - UniCardia & UniMedica & UniEstetica
  - Krosno, Poland, 38-400
    - Completed
    - Intercard Spolka z ograniczona odpowiedzialnoscia
  - Lodz, Poland, 93-338
    - Active, not recruiting
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Poland, 91-347
    - Active, not recruiting
    - Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego,
  - Lodz, Poland, 90-302
    - Completed
    - Santa Sp. z o.o.
  - Lublin, Poland, 20-011
    - Active, not recruiting
    - Clinical Best Solutions Sp. z o.o., Sp. k
  - Miechów, Poland, 32-200
    - Active, not recruiting
    - Szpital Sw. Anny w Miechowie
  - Ostrów Wielkopolski, Poland, 63-400
    - Completed
    - Jantar Sp. z o.o.
  - Przemyśl, Poland, 37-700
    - Active, not recruiting
    - Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
  - Rzeszów, Poland, 35-111
    - Completed
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie
  - Rzeszów, Poland, 35-205
    - Completed
    - EMED Centrum Usług Medycznych Ewa Smialek
  - Rzeszów, Poland, 35-302
    - Completed
    - Korczowski Bartosz Gabinet Lekarski
  - Sztum, Poland, 82-400
    - Completed
    - American Heart of Poland S.A.
  - Tychy, Poland, 43-100
    - Recruiting
    - American Heart of Poland S.A.
  - Warsaw, Poland, 02-777
    - Not yet recruiting
    - Polimedica Centrum Badań, Profilaktyki i Leczenia Sp. z o. o.
  - Warsaw, Poland, 04-501
    - Not yet recruiting
    - Medical Network Sp. z o. o.
  - Warsaw, Poland, 02-777
    - Completed
    - Polimedica Centrum Badań, Profilaktyki i Leczenia Sp. z o. o.
  - Warsaw, Poland, 04-141
    - Completed
    - Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
  - Warsaw, Poland, 04-501
    - Completed
    - Medical Network Sp. z o. o.
  - Łask, Poland, 98-100
    - Active, not recruiting
    - Szpitale Powiatowe Sp. z o.o.
  - Świnoujście, Poland, 72-600
    - Active, not recruiting
    - Balticmed Świnoujście Sp. z o. o.
  - Żarów, Poland, 58-130
    - Recruiting
    - NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
  - Żarów, Poland, 58-130
    - Active, not recruiting
    - NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
- Kuyavian-Pomeranian Voivodeship
  - Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
    - Active, not recruiting
    - Wojewodzki Szpital Zespolony Im.L.Rydygiera W Toruniu
  - Włocławek, Kuyavian-Pomeranian Voivodeship, Poland, 87-800
    - Active, not recruiting
    - Kardio Life - Tomasz Borkowski
- Lesser Poland Voivodeship
  - Chrzanów, Lesser Poland Voivodeship, Poland, 32-500
    - Active, not recruiting
    - American Heart of Poland S.A.
  - Krakow, Lesser Poland Voivodeship, Poland, 30-701
    - Not yet recruiting
    - MediNess Sp. z o.o.
  - Krakow, Lesser Poland Voivodeship, Poland, 30-701
    - Active, not recruiting
    - MediNess Sp. z o.o.
- Lower Silesian Voivodeship
  - Wroclaw, Lower Silesian Voivodeship, Poland, 50-981
    - Active, not recruiting
    - 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
  - Wroclaw, Lower Silesian Voivodeship, Poland, 51-134
    - Active, not recruiting
    - Zdrowie S.C. Agnieszka I Donald Drozdz
  - Wroclaw, Lower Silesian Voivodeship, Poland, 50-556
    - Completed
    - Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego
- Masovian Voivodeship
  - Grodzisk Mazowiecki, Masovian Voivodeship, Poland, 05-825
    - Active, not recruiting
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
  - Warsaw, Masovian Voivodeship, Poland, 00-416
    - Completed
    - Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Poland, 15-111
    - Active, not recruiting
    - Panek Med Centrum Leczenia Chorob Naczyn
  - Bialystok, Podlaskie Voivodeship, Poland, 15-540
    - Completed
    - Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
- Pomeranian Voivodeship
  - Gdynia, Pomeranian Voivodeship, Poland, 81-157
    - Active, not recruiting
    - Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
- Silesian Voivodeship
  - Dąbrowa Górnicza, Silesian Voivodeship, Poland, 41-300
    - Completed
    - American Heart of Poland S.A.
  - Katowice, Silesian Voivodeship, Poland, 40-648
    - Active, not recruiting
    - Pro Familia Altera Sp. z o.o.
  - Katowice, Silesian Voivodeship, Poland, 40-635
    - Active, not recruiting
    - Gornoslaskie Centrum Medyczne Im Prof. Leszka Gieca Sląskiego Uniwersytetu Medycznego W Katowicach
  - Ruda Śląska, Silesian Voivodeship, Poland, 41-710
    - Active, not recruiting
    - Poradnia AKA-MED Centrum Sp. z o.o.
  - Tychy, Silesian Voivodeship, Poland, 43-100
    - Active, not recruiting
    - American Heart of Poland S.A.
  - Zabrze, Silesian Voivodeship, Poland, 41-800
    - Completed
    - Slaskie Centrum Chorob Serca W Zabrzu
- Łódź Voivodeship
  - Bełchatów, Łódź Voivodeship, Poland, 97-400
    - Completed
    - American Heart of Poland S.A.
  - Lodz, Łódź Voivodeship, Poland, 90-549
    - Active, not recruiting
    - Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
  - Zgierz, Łódź Voivodeship, Poland, 95-100
    - Recruiting
    - American Heart of Poland S.A.
  - Zgierz, Łódź Voivodeship, Poland, 95-100
    - Active, not recruiting
    - American Heart of Poland S.A.
Portugal
- - Alcabideche, Portugal, 2755-009
    - Active, not recruiting
    - Hospital de Cascais
  - Braga, Portugal, 4710-243
    - Active, not recruiting
    - ULS De Braga, E.P.E. - Hospital de Braga
  - Figueira da Foz Municipality, Portugal, 3094-001
    - Completed
    - ULS Do Baixo Mondego, E.P.E. - Hospital Distrital Figueira Da Foz
  - Guarda, Portugal, 6301-858
    - Active, not recruiting
    - ULS Da Guarda E.P.E. - Hospital Sousa Martins
  - Guilhufe - Penafiel, Portugal, 4560-136
    - Active, not recruiting
    - ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo
  - Leiria, Portugal, 2410-197
    - Completed
    - ULS Regiao De Leiria E.P.E.- Hospital de Santo André
  - Lisbon, Portugal, 1500-650
    - Recruiting
    - Hospital da Luz
  - Lisbon, Portugal, 1649-035
    - Recruiting
    - Centro Hospitalar Lisboa Norte
  - Lisbon, Portugal, 1449-005
    - Active, not recruiting
    - Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital São Francisco Xavier
  - Lisbon, Portugal, 1649-035
    - Active, not recruiting
    - Unidade Local De Saúde De Santa Maria E.P.E.
  - Lisbon, Portugal, 1998-018
    - Completed
    - Hospital Cuf Descobertas S.A.
  - Lisbon, Portugal, 1500-650
    - Active, not recruiting
    - Hospital da Luz Lisboa, S.A.
  - Porto, Portugal, 4099-001
    - Recruiting
    - Unidade Local de Saude de Santo Antonio, E.P.E.
  - Santa Maria da Feira, Portugal, 4520-211
    - Active, not recruiting
    - ULS Entre Douro e Vouga E.P.E. - Hospital São Sebastião
  - Setúbal, Portugal, 2910-446
    - Active, not recruiting
    - ULS Da Arrábida, E.P.E._Hospital de São Bernardo
  - Setúbal, Portugal, 2900-722
    - Active, not recruiting
    - Hospital da Luz Setúbal, S.A.
Romania
- - Baia Mare, Romania, 430222
    - Active, not recruiting
    - Cabinet Medical de Cardiologie Dr. Calin Pop
  - Brasov, Romania, 500283
    - Active, not recruiting
    - Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
  - Brasov, Romania, 500091
    - Active, not recruiting
    - S.C. Centrul Medical Unirea S.R.L.
  - Brasov, Romania, 500326
    - Completed
    - Spitalul Clinic Judetean de Urgenta Brasov
  - Brăila, Romania, 810325
    - Active, not recruiting
    - Spitalul Judetean de Urgenta Braila
  - Bucharest, Romania, 011461
    - Active, not recruiting
    - Spitalul Universitar de Urgenta Elias
  - Bucharest, Romania, 010825
    - Not yet recruiting
    - "Carol Davila" Military Emergency Hospital
  - Bucharest, Romania, 020339
    - Recruiting
    - Donna Medplus S.R.L.
  - Bucharest, Romania, 021337
    - Not yet recruiting
    - Ecocard Srl
  - Bucharest, Romania, 022328
    - Active, not recruiting
    - Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu
  - Bucharest, Romania, 050098
    - Active, not recruiting
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Romania, 011053
    - Active, not recruiting
    - Hightech Medical Services S.R.L.
  - Bucharest, Romania, 010825
    - Completed
    - "Carol Davila" Military Emergency Hospital
  - Bucharest, Romania, 012292
    - Active, not recruiting
    - Lotus Med SRL
  - Bucharest, Romania, 014146
    - Completed
    - Centrul Medical Emerald
  - Bucharest, Romania, 020339
    - Completed
    - Donna Medplus S.R.L.
  - Bucharest, Romania, 021337
    - Completed
    - Ecocard Srl
  - Bucharest, Romania, 021875
    - Active, not recruiting
    - Davius Clinicmed Srl
  - Bucharest, Romania, 042122
    - Completed
    - Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti
  - Buzău, Romania, 120133
    - Active, not recruiting
    - Mat Cord Biomedica S.R.L.
  - Constanța, Romania, 900591
    - Recruiting
    - Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
  - Constanța, Romania, 900591
    - Active, not recruiting
    - Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
  - Craiova, Romania, 200383
    - Not yet recruiting
    - Neurocord Medical SRL
  - Craiova, Romania, 200383
    - Completed
    - Neurocord Medical SRL
  - Craiova, Romania, 200513
    - Active, not recruiting
    - Cardiomed SRL
  - Galati, Romania, 800291
    - Active, not recruiting
    - SC Diamed Obesity SRL
  - Iași, Romania, 700503
    - Recruiting
    - Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
  - Iași, Romania, 700547
    - Active, not recruiting
    - SC Consultmed SRL
  - Iași, Romania, 700503
    - Active, not recruiting
    - Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
  - Iași, Romania, 700732
    - Completed
    - SC Cardiomed SRL
  - Oradea, Romania, 410469
    - Recruiting
    - Spitalul Clinic Judetean De Urgenta Bihor
  - Oradea, Romania, 410469
    - Active, not recruiting
    - Spitalul Clinic Judetean De Urgenta Bihor
  - Paşcani, Romania, 705200
    - Active, not recruiting
    - Bella Praxis S.R.L.
  - Piteşti, Romania, 110424
    - Active, not recruiting
    - Sc Sal Med Srl
  - Satu Mare, Romania, 440055
    - Completed
    - Spital Judetean de Urgenta Satu Mare
  - Timișoara, Romania, 300254
    - Active, not recruiting
    - Spitalul Clinic Municipal de Urgenta Timisoara
  - Timișoara, Romania, 300310
    - Active, not recruiting
    - Institutul de Boli Cardiovasculare Timișoara
  - Timișoara, Romania, 300366
    - Completed
    - Echipa Medical.33 S.R.L
  - Târgu Mureş, Romania, 540136
    - Active, not recruiting
    - Emergency Institute For Cardiovascular Diseases And Transplant
  - Târgu Mureş, Romania, 540136
    - Active, not recruiting
    - Spitalul Clinic Judetean de Urgenta Targu Mures
- Targu Mures
  - Târgu Mureş, Targu Mures, Romania, 540143
    - Active, not recruiting
    - CMI Dr. Cristian Podoleanu
Serbia
- - Belgrade, Serbia, 11080
    - Recruiting
    - Clinical Hospital Center Bezanijska Kosa
  - Belgrade, Serbia, 11000
    - Recruiting
    - Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
  - Belgrade, Serbia, 11000
    - Recruiting
    - Emergency Internal Medicine Clinic
  - Belgrade, Serbia, 11000
    - Active, not recruiting
    - Clinical centre of Serbia, Clinic for cardiology
  - Belgrade, Serbia, 11080
    - Active, not recruiting
    - Clinical Hospital Center Bezanijska Kosa
  - Belgrade, Serbia, 11000
    - Active, not recruiting
    - Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
  - Belgrade, Serbia, 11000
    - Completed
    - Emergency Internal Medicine Clinic
  - Belgrade, Serbia, 11000
    - Active, not recruiting
    - General Hospital "Euromedik 2"
  - Belgrade, Serbia, 11000
    - Completed
    - Institute for Cardiovascular Diseases ''Dedinje''
  - Belgrade, Serbia, 11080
    - Active, not recruiting
    - Clinical Hospital Centre Zemun
  - Kamenitz, Serbia, 21204
    - Active, not recruiting
    - Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica
  - Kragujevac, Serbia, 34000
    - Active, not recruiting
    - University Clinical Centre Kragujevac
  - Leskovac, Serbia, 16000
    - Completed
    - Medical center Leskovac
  - Niš, Serbia, 18108
    - Active, not recruiting
    - University Clinical Centre Nis, Clinic for Cardiology
  - Užice, Serbia, 31000
    - Active, not recruiting
    - Medical center Uzice
Singapore
- - Singapore, Singapore, 169609
    - Recruiting
    - National Heart Centre Singapore
  - Singapore, Singapore, 529889
    - Recruiting
    - Changi General Hospital
  - Singapore, Singapore, 768828
    - Recruiting
    - Khoo Teck Puat Hospital
  - Singapore, Singapore, 544886
    - Recruiting
    - Sengkang General Hospital
  - Singapore, Singapore, 119074
    - Recruiting
    - National University Hospital Singapore
  - Singapore, Singapore, 308433
    - Completed
    - Tan Tock Seng Hospital
Slovakia
- - Bratislava, Slovakia, 833 48
    - Active, not recruiting
    - Narodny ustav srdcovych a cievnych chorob, a.s.
  - Bratislava, Slovakia, 833 48
    - Completed
    - Narodny ustav srdcovych a cievnych chorob, a.s.
  - Bratislava, Slovakia, 84108
    - Active, not recruiting
    - KARDIO-SANUS, spol. s r.o.
  - Košice, Slovakia, 040 22
    - Active, not recruiting
    - Cardio D&R, s.r.o.
  - Malacky, Slovakia, 901 22
    - Active, not recruiting
    - Nemocnicna a.s.
  - Martin, Slovakia, 036 01
    - Completed
    - MED-CENTRUM, s.r.o.
  - Nitra, Slovakia, 949 01
    - Completed
    - Intradia s.r.o.
  - Piešťany, Slovakia, 92101
    - Completed
    - BENIMED, s.r.o.
  - Trnava, Slovakia, 917 02
    - Active, not recruiting
    - Fakultna nemocnica Trnava
  - Žilina, Slovakia, 010 01
    - Active, not recruiting
    - MEDIVASA, s.r.o., Kardiologicka ambulancia 1, 2
- Banská Bystrica Region
  - Brezno, Banská Bystrica Region, Slovakia, 977 01
    - Active, not recruiting
    - Nemocnica S Poliklinikou Brezno N.O.
- Presov
  - Svidník, Presov, Slovakia, 089 01
    - Active, not recruiting
    - Interna SK s.r.o.
Slovenia
- - Celje, Slovenia, 3000
    - Completed
    - General hospital Celje - cardiology
  - Ljubljana, Slovenia, 1000
    - Active, not recruiting
    - UKC Ljubljana, Cardiology department
  - Maribor, Slovenia, 2000
    - Recruiting
    - UKC Maribor - cardiology
  - Maribor, Slovenia, 2000
    - Active, not recruiting
    - UKC Maribor - cardiology
South Africa
- Eastern Cape
  - George, Eastern Cape, South Africa, 6529
    - Completed
    - Excellentis Clinical Trial Consultants
- Free State
  - Bloemfontein, Free State, South Africa, 9301
    - Recruiting
    - Iatros International
  - Bloemfontein, Free State, South Africa, 9301
    - Recruiting
    - Josha Research
  - Bloemfontein, Free State, South Africa, 9301
    - Recruiting
    - Cardiology Research_Bloemfontein
- Gauteng
  - Benoni, Gauteng, South Africa, 1501
    - Completed
    - East Rand Physicians
  - Centurion, Gauteng, South Africa, 0157
    - Completed
    - Johese Clinical Research
  - Johannesburg, Gauteng, South Africa, 2193
    - Recruiting
    - Wits Clinical Research
  - Johannesburg, Gauteng, South Africa, 2013
    - Recruiting
    - Wits Bara Clinical Trial Site
  - Johannesburg, Gauteng, South Africa, 2192
    - Active, not recruiting
    - Dr Garda Cardiology Practice
  - Lenasia, Gauteng, South Africa, 1827
    - Recruiting
    - Lenasia Clinical Trial Centre
  - Midrand, Gauteng, South Africa, 1685
    - Not yet recruiting
    - Shop#1 Health Emporium
  - Pretoria, Gauteng, South Africa, 0157
    - Recruiting
    - Raslouw Private Hospital
  - Pretoria, Gauteng, South Africa, 0002
    - Not yet recruiting
    - Ryexo Clinical Research
  - Pretoria, Gauteng, South Africa, 0184
    - Recruiting
    - Synexus Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, South Africa, 0002
    - Completed
    - Ryexo Clinical Research
  - Pretoria, Gauteng, South Africa, 0083
    - Completed
    - Dr Mpe's Practice
- KwaZulu-Natal
  - KwaDukuza, KwaZulu-Natal, South Africa, 4449
    - Recruiting
    - Clinical Research Institute of South Africa
  - KwaDukuza, KwaZulu-Natal, South Africa, 4449
    - Not yet recruiting
    - Clinical Research Institute of South Africa
- KwwaZulu Natal
  - Durban, KwwaZulu Natal, South Africa, 4300
    - Recruiting
    - KwaPhila Health Solutions
- Western Cape
  - Cape Town, Western Cape, South Africa, 7500
    - Recruiting
    - Tread Research (Pty)Ltd
  - Cape Town, Western Cape, South Africa, 7530
    - Recruiting
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, South Africa, 7130
    - Not yet recruiting
    - Synexus Helderberg Clinical Research Centre
  - Cape Town, Western Cape, South Africa, 7500
    - Recruiting
    - Dr Corbett
  - Cape Town, Western Cape, South Africa, 7935
    - Recruiting
    - Cardiac Clinical Research Unit, University of Cape Town
  - Mossel Bay, Western Cape, South Africa, 6500
    - Recruiting
    - Dr Hendrik Snyman's Practice
  - Somerset West, Western Cape, South Africa, 7130
    - Completed
    - Synexus Helderberg Clinical Research Centre
  - Worcester, Western Cape, South Africa, 6850
    - Not yet recruiting
    - Clinical Projects Research
  - Worcester, Western Cape, South Africa, 6850
    - Completed
    - Clinical Projects Research
South Korea
- - Busan, South Korea, 49241
    - Recruiting
    - Pusan National University Hospital
  - Cheongju-si, South Korea, 28644
    - Recruiting
    - Chungbuk National University Hospital
  - Daegu, South Korea, 42601
    - Recruiting
    - Keimyung University Dongsan Hospital
  - Daejeon, South Korea, 35015
    - Not yet recruiting
    - Chungnam National University Hospital
  - Gwangju, South Korea, 61469
    - Recruiting
    - Chonnam National University Hospital
  - Gyeonggi-do, South Korea, 14068
    - Recruiting
    - Hallym UMC_Pyeongchon
  - Incheon, South Korea, 21565
    - Recruiting
    - Gachon University Gil Medical Center
  - Incheon, South Korea, 22332
    - Not yet recruiting
    - Inha University Hospital
  - Seoul, South Korea, 05505
    - Recruiting
    - Asan Medical Center
  - Seoul, South Korea, 03722
    - Recruiting
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 06351
    - Recruiting
    - Samsung Medical Center
  - Seoul, South Korea, 02841
    - Recruiting
    - Korea University Anam Hospital
  - Seoul, South Korea, 06591
    - Recruiting
    - The Catholic University of Korea, Seoul St. Mary's Hospital
  - Seoul, South Korea, 08308
    - Recruiting
    - Korea University Guro Hospital
  - Seoul, South Korea, 03080
    - Active, not recruiting
    - Seoul National University Hospital
  - Wŏnju, South Korea, 26426
    - Recruiting
    - Wonju Severance Christian Hospital
- Gyeonggi-do
  - Bucheon-si, Gyeonggi-do, South Korea, 14754
    - Not yet recruiting
    - Bucheon Sejong Hospital
  - Seongnam-si, Gyeonggi-do, South Korea, 13620
    - Recruiting
    - Seoul National University Bundang Hospital
- Gyeongsangnam-do
  - Yangsan, Gyeongsangnam-do, South Korea, 50612
    - Not yet recruiting
    - Pusan National University Yangsan Hospital
Spain
- - A Coruña, Spain, 15006
    - Active, not recruiting
    - Complejo Hospitalario Universitario A Coruña
  - Barcelona, Spain, 08003
    - Active, not recruiting
    - Hospital del Mar
  - Barcelona, Spain, 08036
    - Active, not recruiting
    - Hospital Clinic i Provincial
  - Castilleja de la Cuesta, Spain, 41950
    - Not yet recruiting
    - Hospital Vithas Sevilla
  - Las Palmas de Gran Canaria, Spain, 35010
    - Recruiting
    - Hospital Universitario de Gran Canaria Doctor Negrín
  - Las Palmas de Gran Canaria, Spain, 35010
    - Active, not recruiting
    - Hospital Univ. de Gran Canaria Doctor Negrín
  - Madrid, Spain, 28222
    - Recruiting
    - Hospital Universitario Puerta de Hierro Majadahonda
  - Madrid, Spain, 28040
    - Active, not recruiting
    - Hospital Clinico San Carlos
  - Madrid, Spain, 28046
    - Active, not recruiting
    - Hospital Universitario La Paz
  - Madrid, Spain, 28034
    - Active, not recruiting
    - Hospital Ramon y Cajal
  - Madrid, Spain, 28003
    - Active, not recruiting
    - Hospital Univ. La Luz_Cardiología
  - Seville, Spain, 41003
    - Active, not recruiting
    - Clínica Nuevas Tecnologías en Diabetes y Endocrinología
  - Valencia, Spain, 46010
    - Not yet recruiting
    - Fundación para la Investigación del Hospital Clínico de Valencia (INCLIVA)
  - Valencia, Spain, 46014
    - Completed
    - Hospital General de Valencia
- Barcelona
  - Badalona, Barcelona, Spain, 08916
    - Active, not recruiting
    - Hospital Germans Trias i Pujol
  - L'Hospitalet de Llobregat, Barcelona, Spain, 08907
    - Active, not recruiting
    - Hospital De Bellvitge
- Madrid
  - Majadahonda, Madrid, Spain, 28222
    - Active, not recruiting
    - Hospital Universitario Puerta de Hierro Majadahonda
Taiwan
- - Kaohsiung City, Taiwan, 807
    - Recruiting
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - Kaohsiung City, Taiwan, 833
    - Not yet recruiting
    - Chang Gung Memorial Hospital - Kaohsiung Branch
  - Taichung, Taiwan, 407
    - Recruiting
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 433
    - Recruiting
    - Kuang Tien General Hospital
  - Taipei, Taiwan, 112
    - Recruiting
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 110
    - Recruiting
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 112
    - Completed
    - Taipei Veterans General Hospital
  - Taoyuan District, Taiwan, 333
    - Recruiting
    - Chang Gung Medical Foundation - Linkou Branch
Thailand
- - Bangkok, Thailand, 10330
    - Recruiting
    - King Chulalongkorn Memorial Hospital
  - Bangkok, Thailand, 10330
    - Not yet recruiting
    - King Chulalongkorn Memorial Hospital
  - Bangkok, Thailand, 10700
    - Active, not recruiting
    - Siriraj Hospital
  - Bangkok, Thailand, 10210
    - Not yet recruiting
    - Chulabhorn Hospital
  - Bangkok, Thailand, 10330
    - Active, not recruiting
    - King Chulalongkorn Memorial Hospital
  - Bangkok, Thailand, 10300
    - Not yet recruiting
    - Cardio-Vajira
  - Bangkok, Thailand, 10300
    - Recruiting
    - Cardio-Vajira
  - Bangkok, Thailand, 10400
    - Recruiting
    - Ramathibodi Hospital-Cardiovascular metabolic Center
  - Bangkok, Thailand, 10210
    - Completed
    - Chulabhorn hospital_Cardiovascular
  - Bangkok, Thailand, 10300
    - Active, not recruiting
    - Vajira Hospital - Cardio
  - Bangkok, Thailand, 10400
    - Active, not recruiting
    - Ramathibodi Hospital_Cardiovascular metabolic Center
  - Chiang Mai, Thailand, 50200
    - Recruiting
    - Maharaj Nakorn Chiang Mai Hospital
  - Chiang Mai, Thailand, 50200
    - Active, not recruiting
    - Maharaj Nakorn Chiang Mai Hospital_Cardiology
  - Chiang Rai, Thailand, 57000
    - Active, not recruiting
    - Chiang Rai Prachanukroh Hospital
  - Khon Kaen, Thailand, 40002
    - Active, not recruiting
    - Srinagarind Hospital
  - Nakhon Ratchasima, Thailand, 30000
    - Active, not recruiting
    - Maharat Nakhon Ratchasima Hospital
  - Pathum Thani, Thailand, 12120
    - Active, not recruiting
    - Thammasat Hospital_Cardiology
  - Phitsanulok, Thailand, 65000
    - Active, not recruiting
    - Buddhachinaraj Hospital_Cardiology
  - Samutsakhon, Thailand, 74120
    - Active, not recruiting
    - Banphaeo General Hospital
  - Songkhla, Thailand, 90110
    - Active, not recruiting
    - Songklanagarind Hospital
  - Ubon Ratchathani, Thailand, 34000
    - Withdrawn
    - Sunpasitthiprasong Hospital
  - Ubon Ratchathani, Thailand, 34000
    - Completed
    - Sunpasitthiprasong Hospital_Pediatrics Department
- Changwat Pathum Thani
  - Klong Luang, Pathumthani, Changwat Pathum Thani, Thailand, 12120
    - Recruiting
    - Thammasat University Hospital
- Changwat Songkhla
  - Hat Yai, Changwat Songkhla, Thailand, 90110
    - Recruiting
    - Songklanagarind Hospital
Turkey (Türkiye)
- - Afyonkarahisar, Turkey (Türkiye), 03200
    - Not yet recruiting
    - Afyonkarahisar Health Sciences University
  - Afyonkarahisar, Turkey (Türkiye), 03200
    - Recruiting
    - Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
  - Ankara, Turkey (Türkiye), 06800
    - Not yet recruiting
    - Ankara Sehir Hastanesi Cardiology
  - Ankara, Turkey (Türkiye), 06800
    - Active, not recruiting
    - Ankara Bilkent Şehir Hastanesi-Kardiyoloji
  - Ankara, Turkey (Türkiye), 06230
    - Active, not recruiting
    - Hacettepe Üniversitesi Hastanesi- Kardiyoloji
  - Antalya, Turkey (Türkiye), 07059
    - Not yet recruiting
    - Akdeniz University Medical Faculty
  - Antalya, Turkey (Türkiye), 07059
    - Active, not recruiting
    - Akdeniz Üniversitesi Hastanesi-Kardiyoloji
  - Edirne, Turkey (Türkiye), 22030
    - Active, not recruiting
    - Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
  - Eskişehir, Turkey (Türkiye), 26040
    - Active, not recruiting
    - Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
  - Istanbul, Turkey (Türkiye), 34303
    - Not yet recruiting
    - Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training Research Hospital_Istanbul
  - Istanbul, Turkey (Türkiye), 34098
    - Active, not recruiting
    - İstanbul Üniversitesi-Cerrahpaşa Tıp Fakültesi Kardiyoloji Enstitüsü
  - Istanbul, Turkey (Türkiye), 34303
    - Completed
    - Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH
  - Istanbul, Turkey (Türkiye), 34668
    - Completed
    - Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
  - Izmir, Turkey (Türkiye), 35100
    - Active, not recruiting
    - Ege Üniversitesi Hastanesi- Kardiyoloji
  - Izmir, Turkey (Türkiye), 35340
    - Active, not recruiting
    - Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
  - Kayseri, Turkey (Türkiye), 38039
    - Active, not recruiting
    - Erciyes Üniversitesi Hastanesi- Kardiyoloji
  - Kocaeli, Turkey (Türkiye), 41380
    - Active, not recruiting
    - Kocaeli Üniversitesi Hastanesi- Kardiyoloji
  - Mersin, Turkey (Türkiye), 33343
    - Active, not recruiting
    - Mersin Üniversitesi Hastanesi- Kardiyoloji
United Kingdom
- - Aberdeen, United Kingdom, AB25 2ZN
    - Active, not recruiting
    - Aberdeen Royal Infirmary
  - Bristol, United Kingdom, BS10 5NB
    - Not yet recruiting
    - Southmead Hospital
  - Bristol, United Kingdom, BS10 5NB
    - Active, not recruiting
    - Southmead Hospital
  - Craigavon, United Kingdom, BT63 5QQ
    - Active, not recruiting
    - Craigavon Area Hospital_Cardiovascular Research Unit
  - Dorest, United Kingdom, BH7 7DW
    - Not yet recruiting
    - Royal Bournemouth Hospital
  - Exeter, United Kingdom, EX2 5DW
    - Active, not recruiting
    - Royal Devon and Exeter Hospital
  - Exeter, United Kingdom, EX2 5DW
    - Not yet recruiting
    - Royal Devon University Healthcare NHS Foundation Trust
  - Glasgow, United Kingdom, G31 2ER
    - Active, not recruiting
    - Glasgow Royal Infirmary
  - High Wycombe, United Kingdom, HP11 2TT
    - Recruiting
    - Wycombe General Hospital
  - High Wycombe, United Kingdom, HP11 2TT
    - Active, not recruiting
    - Wycombe General Hospital
  - Liverpool, United Kingdom, L9 7AL
    - Active, not recruiting
    - Aintree University Hospital
  - Manchester, United Kingdom, M13 9WL
    - Active, not recruiting
    - Manchester Royal Infirmary - Manchester Heart Centre
  - North Shields, United Kingdom, NE29 8NH
    - Active, not recruiting
    - North Tyneside General Hospital
  - Oldham, United Kingdom, OL1 2JH
    - Not yet recruiting
    - The Royal Oldham Hospital_Cardiology Outpatients Dept.
  - Oxford, United Kingdom, OX3 9DU
    - Not yet recruiting
    - John Radcliffe Hospital
  - Oxford, United Kingdom, OX3 9DU
    - Active, not recruiting
    - John Radcliffe Hospital
  - Stockton-on-Tees, United Kingdom, TS19 8PE
    - Not yet recruiting
    - University of North Tees Hospital
  - Stockton-on-Tees, United Kingdom, TS19 8PE
    - Active, not recruiting
    - University of North Tees Hospital
- Dorset
  - Bournemouth, Dorset, United Kingdom, BH7 7DW
    - Active, not recruiting
    - Royal Bournemouth Hospital
- Essex
  - Basildon, Essex, United Kingdom, SS16 5NL
    - Not yet recruiting
    - Basildon University Hospital
  - Basildon, Essex, United Kingdom, SS16 5NL
    - Active, not recruiting
    - Basildon University Hospital
- Lanarkshire
  - Airdrie, Lanarkshire, United Kingdom, ML6 0JS
    - Active, not recruiting
    - University Hospital Monklands - Cardiology Research
- London
  - Tooting, London, United Kingdom, SW17 0RE
    - Not yet recruiting
    - St George's Hospital
  - Tooting, London, United Kingdom, SW17 0RE
    - Active, not recruiting
    - St George's Hospital - Cardiology
- South Lanarkshire
  - East Kilbride, South Lanarkshire, United Kingdom, G74 8RG
    - Active, not recruiting
    - University Hospital Hairmyres - Cardiology
- West Sussex
  - Chichester, West Sussex, United Kingdom, PO19 6SE
    - Recruiting
    - St. Richards Hospital
  - Chichester, West Sussex, United Kingdom, PO19 6SE
    - Active, not recruiting
    - St. Richard's Hospital_Cardiology
United States
- Alabama
  - Alexander City, Alabama, United States, 35010
    - Recruiting
    - Advanced Cardiovascular, LLC
  - Fairhope, Alabama, United States, 36532
    - Recruiting
    - Eastern Shore Rsrch Inst, LLC
  - Huntsville, Alabama, United States, 35801
    - Recruiting
    - Heart Center Rsrch_Hunstville
- Arizona
  - Phoenix, Arizona, United States, 85006
    - Not yet recruiting
    - Banner University Medical Ctr
  - Phoenix, Arizona, United States, 85006
    - Completed
    - Banner University Medical Ctr
- Arkansas
  - Little Rock, Arkansas, United States, 72204
    - Completed
    - Cardiology & Medicine Clinic
- California
  - Alhambra, California, United States, 91801
    - Recruiting
    - InvivoCure -2
  - Beverly Hills, California, United States, 90211
    - Recruiting
    - National Heart Institute Cal
  - Covina, California, United States, 91723
    - Recruiting
    - Valley Clinical Trials
  - La Jolla, California, United States, 90237
    - Completed
    - Scripps Memorial Hospital La Jolla
  - La Mesa, California, United States, 91942
    - Recruiting
    - Purushotham & Akther Kotha MD, inc.
  - Loma Linda, California, United States, 92357
    - Recruiting
    - VA Loma Linda Hlthcr Sys
  - Los Angeles, California, United States, 90073
    - Recruiting
    - VA Greater Los Angeles Hlthcare System
  - Los Angeles, California, United States, 90035
    - Recruiting
    - Biopharma Clinical Research Services, LLC
  - Los Angeles, California, United States, 90073
    - Recruiting
    - VAGrtrLosAngelesHlthcareSystem
  - Northridge, California, United States, 91325
    - Recruiting
    - Valley Clinical Trials, Inc.
  - Orange, California, United States, 92868
    - Completed
    - UCI Health
  - Palo Alto, California, United States, 94304
    - Completed
    - Stanford Univ School of Med
  - San Diego, California, United States, 92123
    - Recruiting
    - San Diego Cardiac Center
  - San Dimas, California, United States, 91773
    - Recruiting
    - North America Research Institute
  - Stockton, California, United States, 95204
    - Recruiting
    - Manshadi Heart Institute
  - Torrance, California, United States, 90502
    - Recruiting
    - Lundquist Inst-Biomed Innovtn
  - Van Nuys, California, United States, 91405
    - Recruiting
    - InvivoCure
- Colorado
  - Aurora, Colorado, United States, 80045
    - Recruiting
    - Rocky Mountain Regional VAMC
  - Denver, Colorado, United States, 80012
    - Completed
    - InvivoCure -2
  - Littleton, Colorado, United States, 80120
    - Completed
    - S Denver Cardiology Associates
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Recruiting
    - Bridgeport Hospital
  - Stamford, Connecticut, United States, 06905
    - Recruiting
    - Cardiology Associates of Fairfield County
- Florida
  - Coral Gables, Florida, United States, 33134
    - Recruiting
    - Pioneer Clinical Studies-Coral Gables
  - Crystal River, Florida, United States, 34429
    - Recruiting
    - Nature Coast Clin Rsrch_Crystal River
  - Fort Lauderdale, Florida, United States, 33312
    - Completed
    - Integrative Research Assoc Inc
  - Hialeah, Florida, United States, 33016
    - Recruiting
    - New Generation of Medical Research
  - Hialeah, Florida, United States, 33016
    - Not yet recruiting
    - New Generation of Medical Research
  - Hollywood, Florida, United States, 33021
    - Recruiting
    - Memorial Region Hosp_Hollywood
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - Jacksonville Ctr For Clin Res
  - Jacksonville, Florida, United States, 32258
    - Recruiting
    - Baptist Health Research Institute
  - Jacksonville, Florida, United States, 32204
    - Completed
    - E Coast Inst for Rsrch LLC_Jacksonville
  - Miami, Florida, United States, 33173
    - Recruiting
    - Baptist Health South Florida
  - Miami, Florida, United States, 33176
    - Recruiting
    - Pioneer Clinical Studies-Coral Gables
  - Naples, Florida, United States, 34102
    - Recruiting
    - NCH Research Institute
  - North Miami Beach, Florida, United States, 33169
    - Recruiting
    - Amavita Research Services, LLC
  - Ocala, Florida, United States, 34471
    - Recruiting
    - Ocala Cardiovascular Research
  - Ormond Beach, Florida, United States, 32174
    - Recruiting
    - Ormond Beach Clinical Research
  - Saint Augustine, Florida, United States, 32086
    - Recruiting
    - St Johns Ctr Clin Rsch-St. Aug
  - Wellington, Florida, United States, 33449
    - Recruiting
    - Cardio Partners Clin Res Inst
  - Winter Haven, Florida, United States, 33881
    - Recruiting
    - Winter Haven Hospital
  - Winter Park, Florida, United States, 32792
    - Recruiting
    - Guardian Research Org LLC
- Georgia
  - Atlanta, Georgia, United States, 30310
    - Recruiting
    - Morehouse School of Medicine
  - Atlanta, Georgia, United States, 30322
    - Recruiting
    - Emory University School of Medicine_Atlanta
  - Johns Creek, Georgia, United States, 30024
    - Recruiting
    - NSC Research, Inc
  - Macon, Georgia, United States, 31201
    - Recruiting
    - GA Arrhythmia Cons & Rsch Inst
- Hawaii
  - Honolulu, Hawaii, United States, 96817
    - Completed
    - The Queen's Medical Center
- Idaho
  - Meridian, Idaho, United States, 83642
    - Recruiting
    - St. Luke's Idaho Cardiology Associates
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Completed
    - Endeavor Health Clinical Operations-NCH
  - Downers Grove, Illinois, United States, 60515
    - Completed
    - Advocate Good Samaritan
  - Hazel Crest, Illinois, United States, 60429
    - Recruiting
    - Chicago Medical Research LLC
  - Naperville, Illinois, United States, 60540
    - Recruiting
    - Midwest Cardiovascular Institute
  - Peoria, Illinois, United States, 61636
    - Recruiting
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, United States, 61614
    - Recruiting
    - OSF HealthCare_Cardiovasc Inst
- Indiana
  - Elkhart, Indiana, United States, 46514
    - Recruiting
    - Midwest Cardiovascu Rsrch Foundation
  - Hammond, Indiana, United States, 46324
    - Recruiting
    - Asha Clinical Rsch-Munster, LLC
  - Indianapolis, Indiana, United States, 46237
    - Recruiting
    - Franciscan Network-IN Heart PHY
  - Indianapolis, Indiana, United States, 46237
    - Completed
    - Franciscan Network-IN Heart PHY
  - Lebanon, Indiana, United States, 46052
    - Completed
    - Witham Health Services
  - Munster, Indiana, United States, 46321
    - Recruiting
    - Cardiovascular Rsrch of NW_IN
  - Richmond, Indiana, United States, 47374
    - Recruiting
    - Reid Physician Associates
- Iowa
  - Iowa City, Iowa, United States, 52242
    - Recruiting
    - University of Iowa Hospitals and Clinics
- Kansas
  - Overland Park, Kansas, United States, 66211
    - Recruiting
    - Midwest Heart & Vasc Spec
  - Overland Park, Kansas, United States, 66211
    - Not yet recruiting
    - Midwest Heart & Vasc Spec
- Kentucky
  - Elizabethtown, Kentucky, United States, 42701
    - Recruiting
    - Baptist Health Hardin
  - Lexington, Kentucky, United States, 40503
    - Completed
    - The Research Group of Lexington LLC
  - Louisville, Kentucky, United States, 40207
    - Recruiting
    - Baptist Health Louisville
  - Louisville, Kentucky, United States, 40202
    - Completed
    - University of Louisville
  - Louisville, Kentucky, United States, 40206
    - Completed
    - Robley Rex VA Medical Center
- Louisiana
  - Alexandria, Louisiana, United States, 71301
    - Completed
    - Cambridge Medical Trials
  - Bogalusa, Louisiana, United States, 70427
    - Recruiting
    - Louisiana Heart Center
  - Hammond, Louisiana, United States, 70403
    - Recruiting
    - Heart Clinic of Hammond
  - New Orleans, Louisiana, United States, 70112
    - Recruiting
    - University Medical Center New Orleans
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Recruiting
    - Ascension Saint Agnes Heart Ca
  - Baltimore, Maryland, United States, 21287
    - Recruiting
    - Johns Hopkins University_Baltimore
  - Lanham, Maryland, United States, 20706
    - Recruiting
    - Capitol Cardiology Assoc_Lanham
  - Oxon Hill, Maryland, United States, 20745
    - Recruiting
    - MD Medical Research
- Massachusetts
  - Haverhill, Massachusetts, United States, 01830
    - Recruiting
    - Pentucket Medical Associates
- Michigan
  - Ann Arbor, Michigan, United States, 48109
    - Completed
    - University of Michigan Medicine
  - Detroit, Michigan, United States, 48201
    - Recruiting
    - Detroit Med Center-Wayne State
  - Detroit, Michigan, United States, 48202
    - Completed
    - Henry Ford Hlth System_Detroit
  - Flint, Michigan, United States, 48532
    - Completed
    - Elite Research Center
  - Grand Rapids, Michigan, United States, 49546
    - Completed
    - Healthy Heart Cardiology
  - Ypsilanti, Michigan, United States, 48197
    - Recruiting
    - Trinity Health Michigan Heart
- Minnesota
  - Maplewood, Minnesota, United States, 55109
    - Recruiting
    - Fairview Health Services
  - Minneapolis, Minnesota, United States, 55417
    - Recruiting
    - Minneapolis VA Health Care Sys
- Mississippi
  - Diamondhead, Mississippi, United States, 39525
    - Not yet recruiting
    - Hawthorne Health
  - Tupelo, Mississippi, United States, 38801
    - Completed
    - Cardiolg Assoc Rsch LLC_Tupelo
- Missouri
  - St Louis, Missouri, United States, 63136
    - Recruiting
    - St Louis Heart & Vascular, P.C.
- Montana
  - Kalispell, Montana, United States, 59901
    - Completed
    - Logan Health Research
- Nebraska
  - Omaha, Nebraska, United States, 68198
    - Recruiting
    - Univ. of Nebraska Medical Center_Omaha
  - Omaha, Nebraska, United States, 68198
    - Completed
    - Univ. of Nebraska Medical Center_Omaha
- Nevada
  - Las Vegas, Nevada, United States, 89128
    - Recruiting
    - Palm Research Center Inc.
- New Jersey
  - Bridgewater, New Jersey, United States, 08807-3064
    - Completed
    - Advanced Heart Care LLC
  - Elmer, New Jersey, United States, 08318
    - Completed
    - Heart House_Elmer
  - Linden, New Jersey, United States, 07036
    - Not yet recruiting
    - NJ Heart
  - Linden, New Jersey, United States, 07036
    - Recruiting
    - NJ Heart
  - Livingston, New Jersey, United States, 07039
    - Recruiting
    - Barnabas Health
  - Livingston, New Jersey, United States, 07039
    - Completed
    - Barnabas Health
  - Mullica Hill, New Jersey, United States, 08062
    - Recruiting
    - Inspira Health
  - Newark, New Jersey, United States, 07102
    - Recruiting
    - Saint Michael's Med Ctr NJ
  - Newark, New Jersey, United States, 07102
    - Not yet recruiting
    - Saint Michael's Med Ctr NJ
  - Ridgewood, New Jersey, United States, 07450
    - Not yet recruiting
    - The Valley Hosptial
  - Ridgewood, New Jersey, United States, 07450
    - Completed
    - The Valley Hosptial
- New York
  - Albany, New York, United States, 12211
    - Recruiting
    - Capital Cardiology Associates_Albany
  - Buffalo, New York, United States, 14215
    - Completed
    - University at Buffalo_Erie County Med Ctr
  - Kew Gardens, New York, United States, 11415
    - Completed
    - Marian David, MD, PC
  - New York, New York, United States, 10021
    - Recruiting
    - NY Presbyt Hosp-W Cornell Med
  - New York, New York, United States, 10019
    - Recruiting
    - Mount Sinai Hosp at NYC
  - New York, New York, United States, 10029
    - Recruiting
    - Mount Sinai Hosp at NYC
  - New York, New York, United States, 10035
    - Completed
    - Harlem Cardiology_Madison ave
  - Rosedale, New York, United States, 11422
    - Recruiting
    - Laurelton Heart Specialist PC
  - Saratoga Springs, New York, United States, 12866
    - Recruiting
    - Saratoga Clinical Research
  - Stony Brook, New York, United States, 11794
    - Recruiting
    - Stony Brook University Hospital
  - The Bronx, New York, United States, 10455
    - Recruiting
    - CHEAR Center LLC
- North Carolina
  - Chapel Hill, North Carolina, United States, 27599
    - Completed
    - UNC Cardiology Outpatient Ctr
  - Concord, North Carolina, United States, 28025
    - Not yet recruiting
    - Hawthorne Health NC
  - Durham, North Carolina, United States, 27710
    - Recruiting
    - Duke University
  - Greensboro, North Carolina, United States, 27405
    - Recruiting
    - Medication Mgmnt, LLC_Grnsboro
  - Lumberton, North Carolina, United States, 28358
    - Not yet recruiting
    - Duke University/Southeastern
  - Lumberton, North Carolina, United States, 28358
    - Completed
    - Duke University/Southeastern
  - Morehead City, North Carolina, United States, 28557
    - Recruiting
    - Carteret Medical Group
  - Raleigh, North Carolina, United States, 27607
    - Recruiting
    - UNC Rex Healthcare
- Ohio
  - Canton, Ohio, United States, 44710
    - Recruiting
    - Aultman Hospital
  - Marion, Ohio, United States, 43302
    - Recruiting
    - Rama Research LLC
  - Marion, Ohio, United States, 43302
    - Recruiting
    - K&R Research LLC
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73135
    - Recruiting
    - South Oklahoma Heart Research, LLC
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Recruiting
    - Capital Area Research LLC
  - Camp Hill, Pennsylvania, United States, 17011
    - Recruiting
    - Penn State Hlth Holy Spirit Med Ctr
  - Danville, Pennsylvania, United States, 17822
    - Recruiting
    - Geisinger Medical Center
  - Hershey, Pennsylvania, United States, 17033
    - Completed
    - Penn State Hershey Medical Center
  - Lancaster, Pennsylvania, United States, 17603
    - Completed
    - Heart Grp_ Lancaster Gen Hlth
  - Philadelphia, Pennsylvania, United States, 19114
    - Recruiting
    - Thomas Jefferson University_Philadelphia
  - Pittsburgh, Pennsylvania, United States, 15212
    - Completed
    - Allegheny Health Network
  - Wyomissing, Pennsylvania, United States, 19610
    - Recruiting
    - Penn State Health-Berks Cardiology
- South Carolina
  - Columbia, South Carolina, United States, 29203
    - Completed
    - Prisma Health-Midlands
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Recruiting
    - Monument Health Clinical Rsrch
  - Sioux Falls, South Dakota, United States, 57117
    - Recruiting
    - Sanford Health_Sioux Falls
  - Sioux Falls, South Dakota, United States, 57117
    - Completed
    - Sanford Health_Sioux Falls
- Tennessee
  - Jackson, Tennessee, United States, 38305
    - Recruiting
    - The Jackson Clinic, PA
  - Jackson, Tennessee, United States, 38301
    - Recruiting
    - Apex Research Foundation, LLC
  - Knoxville, Tennessee, United States, 37934
    - Recruiting
    - Tennova HC Turkey Creek MC
- Texas
  - Allen, Texas, United States, 75013
    - Recruiting
    - Heart MD_Allen TX
  - Amarillo, Texas, United States, 79106
    - Recruiting
    - PharmaTex Research, LLC
  - Austin, Texas, United States, 78756
    - Recruiting
    - Austin Heart
  - Dallas, Texas, United States, 75390
    - Recruiting
    - UTD SW Medical Center-Dallas
  - Duncanville, Texas, United States, 75137
    - Recruiting
    - Dallas Heart and Vascular
  - El Paso, Texas, United States, 79905
    - Recruiting
    - David Turbay, MD, PLLC
  - Houston, Texas, United States, 77030
    - Not yet recruiting
    - Houston Methodist Hospital
  - Houston, Texas, United States, 77025
    - Recruiting
    - Biopharma Informatic_Houston
  - Houston, Texas, United States, 77070
    - Recruiting
    - Card Specialists of Willowbrook
  - Houston, Texas, United States, 77030-2703
    - Recruiting
    - Houston Methodist Hospital
  - Houston, Texas, United States, 77030
    - Completed
    - Texas Heart Inst Medical Ctr
  - Houston, Texas, United States, 77030
    - Completed
    - UT Physicians - Houston Medical Center
  - McKinney, Texas, United States, 75071
    - Recruiting
    - Texas Institute of Cardiology PA
  - San Antonio, Texas, United States, 78212
    - Recruiting
    - Clinical Advancement Center
  - San Antonio, Texas, United States, 78229
    - Completed
    - Audie L. Murphy VA Hospital
  - Sherman, Texas, United States, 75092
    - Recruiting
    - Sherman Clinical Research
- Vermont
  - Burlington, Vermont, United States, 05401
    - Recruiting
    - University of Vermont Medical Center
  - Burlington, Vermont, United States, 05401
    - Recruiting
    - University of Vermont Med Ctr
- Virginia
  - Charlottesville, Virginia, United States, 22908
    - Recruiting
    - University of Virginia
  - Chesterfield, Virginia, United States, 23832
    - Recruiting
    - James River Cardiology
  - Falls Church, Virginia, United States, 22042
    - Completed
    - Virginia Heart
  - Manassas, Virginia, United States, 20109
    - Recruiting
    - Carient Heart and Vascular
  - Norfolk, Virginia, United States, 23504
    - Recruiting
    - York Clinical Research LLC
  - Norfolk, Virginia, United States, 23507
    - Recruiting
    - Sentara Health Research Center
  - Richmond, Virginia, United States, 23298
    - Completed
    - Virginia Commonwealth University
  - Roanoke, Virginia, United States, 24014
    - Completed
    - Roanoke Heart Institute
  - Salem, Virginia, United States, 24153-6404
    - Recruiting
    - VA Medical Center_Salem
  - Winchester, Virginia, United States, 22601-3834
    - Recruiting
    - Selma Medical Associates
  - Winchester, Virginia, United States, 22601
    - Recruiting
    - Valley Health Link
  - Winchester, Virginia, United States, 22601-3834
    - Completed
    - Selma Medical Associates
- Washington
  - Seattle, Washington, United States, 98101
    - Completed
    - Virginia Mason Medical Center
  - Seattle, Washington, United States, 98122-5789
    - Not yet recruiting
    - Swedish Medical Center_Seattle
  - Seattle, Washington, United States, 98122-5789
    - Recruiting
    - Swedish Medical Center_Seattle
  - Spokane, Washington, United States, 99204
    - Recruiting
    - Providence Med Research Ctr
- West Virginia
  - Morgantown, West Virginia, United States, 26506
    - Completed
    - WVU Heart & Vascular Institute
- Wisconsin
  - Madison, Wisconsin, United States, 53705
    - Recruiting
    - William S Middleton Mem VA Hosp
  - Milwaukee, Wisconsin, United States, 53215
    - Completed
    - Aurora St. Luke's Medi Ctr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Serum high-sensitivity C-reactive protein (hs-CRP) greater than equal to 2 milligrams per liter (mg/L) at screening (visit 1) Disease specific - cardiovascular
At least one of the following:
1. N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than equal to 300 picograms per milliliter (pg/mL) at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NTproBNP must be greater than equal to 600 pg/mL. Note that the screening electrocardiogram (ECG) must be obtained the same day as sampling for NT-proBNP.
2. Hospitalisation or urgent/unplanned visit with a primary diagnosis of decompensated heart failure which required intravenous loop diuretic treatment, within the last 9 months prior to screening (visit 1) in combination with NT-proBNP greater than equal to 200 pg/mL at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NT-proBNP must be greater than equal to 600 pg/mL.
Diagnosis of heart failure (New York Heart Association [classification] [NYHA] Class II-IV).
Left ventricular ejection fraction (LVEF) greater than 40 percentage (%) documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (e.g., myocardial infarction [MI] or heart failure [HF] hospitalisation).
Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
Left atrial (LA) volume index greater than 34 milliliter per meter square (mL/m^2).
LA diameter greater than equal to 3.8 centimeter (cm).
LA length greater than equal to 5.0 cm.
LA area greater than equal to 20 cm square.
LA volume greater than equal to 55 milliters (mL).
Intraventricular septal thickness greater than equal to 1.1 cm.
Posterior wall thickness greater than equal to 1.1 cm.
Left ventricular (LV) mass index greater than equal to 115 grams per meter square (g⁄m^2 ) in men or greater than equal to 95 g⁄m^2 in women.
E/e' (mean septal and lateral) greater than equal to 10.
e' (mean septal and lateral) less than 9 centimeter per second (cm/s).
No heart failure hospitalisations or urgent heart failure visits between screening (visit 1) and randomisation (visit 2).

Exclusion Criteria:

Medical conditions - cardiovascular

Myocardial infarction, stroke, unstable angina pectoris, transient ischaemic attack, or heart failure hospitalisation, within 30 days prior to screening (visit 1).
Systolic blood pressure greater than equal to 180 millimeters of mercury (mmHg) at screening (visit 1). If the systolic blood pressure is 160-179 mmHg, the patient should be receiving greater than equal to 3 antihypertensive drugs. (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
Heart rate above 110 or below 40 beats per minute as evaluated on the electrocardiogram (ECG) performed at screening (visit 1) (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
Planned coronary, carotid or peripheral artery revascularisation known during the screening period (visit 1). (Note: Planned coronary angiogram is not exclusionary).
Planned cardiac device or atrial flutter/atrial fibrillation ablation procedure known during the screening period (visit 1).
Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
Heart failure due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, uncorrected more than moderate primary valve disease.
Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD.
Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism).

Medical conditions - infections/immunosuppression

- Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Participants will receive ziltivekimab placebo s.c. injection once-monthly and added standard of care for up to 4 years.	Drug: Placebo Ziltivekimab placebo s.c. injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.
Experimental: Ziltivekimab Participants will receive ziltivekimab subcutaneous (s.c.) injection once-monthly and added standard of care for up to 4 years.	Drug: Ziltivekimab Ziltivekimab subcutaneous (s.c.) injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to First Occurrence of a Composite Heart Failure Endpoint Consisting of: Cardiovascular (CV) Death, Heart Failure (HF) Hospitalisation or Urgent HF Visit Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)

Secondary Outcome Measures

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novo Nordisk A/S

Investigators

Study Director: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 8, 2023

Primary Completion (Estimated)

July 2, 2027

Study Completion (Estimated)

July 2, 2027

Study Registration Dates

First Submitted

November 23, 2022

First Submitted That Met QC Criteria

November 23, 2022

First Posted (Actual)

December 5, 2022

Study Record Updates

Last Update Posted (Actual)

March 11, 2026

Last Update Submitted That Met QC Criteria

March 10, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

EX6018-4915
U1111-1280-0810 (Other Identifier: World Health Organization (WHO))
jRCT2031230085 (Registry Identifier: jRCT (Japan))
2022-501939-16-00 (Other Identifier: European Medicines Agency (EMA))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Outcome Measure	Measure Description	Time Frame
Number of CV Deaths, HF Hospitalisations or Urgent HF Visits (First and Recurrent) Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured as count of event.	From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: CV Death, HF Hospitalisation or Urgent HF Visit, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: All-cause Death, HF Hospitalisation or Urgent HF Visit, Non-fatal MI, Non-fatal stroke Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)
Time to Occurrence of CV Death Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of HF Hospitalisation or Urgent HF Visit Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)
Number of Events of Atrial Fibrillation Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured as count of event.	From randomisation (month 0) to end of study (up to 48 months)
Change in KCCQ Clinical Summary Score Time Frame: From randomisation (month 0) to 12 months	KCCQ measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as score.	From randomisation (month 0) to 12 months
Improvement of 5 Points or More in KCCQ Clinical Summary Score (Yes/No) Time Frame: From randomisation (month 0) to 12 months	Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.	From randomisation (month 0) to 12 months
Improvement of 10 Points or More in KCCQ Clinical Summary Score (Yes/No) Time Frame: From randomisation (month 0) to 12 months	Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.	From randomisation (month 0) to 12 months
Improvement in New York Heart Association (Classification) [NYHA Class] (Yes/No) Time Frame: From randomisation (month 0) to 12 months	NEW YORK HEART ASSOCIATION CLASSIFICATION (NYHA) Class I: Participant with cardiac disease but without resulting limitations of physical activity. Class II: Participants with cardiac disease resulting in slight limitation of physical activity. Class III: Participants with cardiac disease resulting in marked limitation of physical activity. Class IV: Participants with cardiac disease resulting in inability to carry on any physical activity without discomfort. Measured as count of participant.	From randomisation (month 0) to 12 months
Change in Estimated Glomerular Filtration Rate (eGFR) (Chronic Kidney Disease - Epidemiology Collaboration [CKD-EPI]) Time Frame: From randomisation (month 0) to 12 months	Measured as mL/min/1.73 m^2.	From randomisation (month 0) to 12 months
Annual Rate of Change in eGFR (CKD-EPI) (Total eGFR Slope) Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured as mL/min/1.73 m^2/year.	From randomisation (month 0) to end of study (up to 48 months)
Number of Hospitalisations With Infection as Primary Cause or Death Due to Infection Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured as count of event.	From randomisation (month 0) to end of study (up to 48 months)
Change in High-sensitivity C-reactive Protein (hs-CRP) Time Frame: From randomisation (month 0) to 12 months	Measured as ratio to baseline.	From randomisation (month 0) to 12 months
Change in N-terminal-pro-brain Natriuretic Peptide (NT-proBNP) Time Frame: From randomisation (month 0) to 12 months	Measured as ratio to baseline.	From randomisation (month 0) to 12 months
Time to Occurrence of all-cause Death Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Measured in months.	From randomisation (month 0) to end of study (up to 48 months)
Hierarchical Composite of: Time to All-cause Death, Number of HF Hospitalisations or Urgent HF Visits, Time to First HF Hospitalisation or Urgent HF Visit, difference of at least 5 in KCCQ clinical summary score change from baseline to 12 months Time Frame: From randomisation (month 0) to end of study (up to 48 months)	Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as total wins for each treatment group.	From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of a Composite Chronic Kidney Disease (CKD) Endpoint Consisting of: CV death, Onset of Persistent Greater Than Equal To 40 Percentage Reduction in eGFR (CKD- EPI) compared with baseline; Kidney failure Time Frame: From randomisation (month 0) to end of study (up to 48 months)	eGFR = estimated glomerular filtration rate; CKD-EPI = chronic kidney disease - epidemiology collaboration. Kidney failure defined as: death from kidney failure, onset of persistent eGFR less than 15 milliliters per minute (mL/min)/1.73 meter square (m^2) (CKD-EPI), initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation). Measured in months.	From randomisation (month 0) to end of study (up to 48 months)

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Heart Failure

Clinical Trials on Placebo

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