A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation (HERMES)

July 3, 2026 updated by: Novo Nordisk A/S

Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

4899

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1181ACH
        • Hospital Italiano
      • Buenos Aires, Argentina, C1426ABP
        • Fundación Respirar
      • Buenos Aires, Argentina, B1704ETD
        • DIM Clínica Privada
      • CABA, Argentina, C1440CFD
        • CEMEDIC
      • CABA, Argentina, C1093AAS
        • Fundacion Favaloro
      • Corrientes, Argentina, W3400AMZ
        • Instituto de Cardiología de Corrientes
      • Mar del Plata, Argentina, B7600GNY
        • Centro de Investigaciones Médicas Clínica de Fracturas y Or
      • Mar del Plata, Argentina, B7600FZN
        • Instituto de Investigaciones Clinicas
      • San Nicolás, Argentina, B2900
        • Instituto de Investigaciones Clinicas San Nicolás
      • Santa Fe, Argentina, 3000
        • Centro de Investigaciones Clinicas del Litoral
      • Santa Fe, Argentina, S3000FSO
        • CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
    • Buenos Aires
      • CABA, Buenos Aires, Argentina, C1128 AAF
        • Mautalen Salud e Investigación
      • CABA, Buenos Aires, Argentina, C1440CFD
        • CEMEDIC
      • Mar del Plata, Buenos Aires, Argentina, B7600FZN
        • Instituto de Investigaciones Clínicas Mar del Plata
      • Mar del Plata, Buenos Aires, Argentina, B7600GNY
        • Centro de Investigaciones Médicas Clínica de Fracturas y Or
      • Mar del Plata, Buenos Aires, Argentina, B7600GNY
        • Centro de Investigaciones Medicas Mar Del Plata
    • Buenos Aires, Argentina
      • CABA, Buenos Aires, Argentina, Argentina, C1093AAS
        • Fundacion Favaloro
    • Santa Fe Province
      • Granadero Baigorria, Santa Fe Province, Argentina, 2152
        • Centro de Investigaciones Clinica Baigorria
      • Santa Fe, Santa Fe Province, Argentina, S2152BOF
        • Centro de Investigaciones Clinica Baigorria
  • Australia
    • Australian Capital Territory
      • Garran, Australian Capital Territory, Australia, 2605
        • Canberra Hospital
    • New South Wales
      • Concord, New South Wales, Australia, 2139
        • Concord Repatriation General Hospital - Cardiology Department
      • Gosford, New South Wales, Australia, 2250
        • Gosford Hospital
      • Liverpool, New South Wales, Australia, 2170
        • Sydney Cardiometabolic Centre
    • Queensland
      • Brisbane, Queensland, Australia, 4029
        • Royal Brisbane and Women's Hospital
      • Chelmer, Queensland, Australia, 4068
        • Heart of Australia
      • Douglas, Queensland, Australia, 4814
        • Townsville University Hospital
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Nightingale Research
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital - Cardiology Department
      • Bedford Park, South Australia, Australia, 5042
        • Flinders Medical Centre
    • Tasmania
      • Hobart, Tasmania, Australia, 7000
        • Royal Hobart Hospital
    • Victoria
      • Frankston, Victoria, Australia, 3199
        • Frankston Hospital
      • Frankston, Victoria, Australia, 3199
        • Peninsula University Hospital - Cardiology Department
      • Geelong, Victoria, Australia, 3220
        • Barwon Health (The Geelong Hospital)
      • Geelong, Victoria, Australia, 3220
        • Adrian Costa Clinical Trials Centre
      • Hoppers Crossing, Victoria, Australia, 3029
        • Baker-HeartWest - Hoppers Crossing
      • Richmond, Victoria, Australia, 3121
        • Epworth HealthCare
    • Western Australia
      • West Perth, Western Australia, Australia, 6005
        • Clinitrials
  • Austria
      • Braunau am Inn, Austria, 5280
        • Krankenhaus St. Josef Braunau
      • Braunau am Inn, Austria, A 5280
        • Krankenhaus St. Josef Braunau
      • Graz, Austria, 8036
        • Medizinische Universität Graz
      • Graz, Austria, A 8036
        • Medizinische Universität Graz
      • Saint Stefan, Austria, 8511
        • Fließer-Görzer [Ordination]
      • Salzburg, Austria, 5020
        • Uniklinikum Salzburg Kardiologie
      • Vienna, Austria, 1090
        • Medizinische Universität Wien
      • Vienna, Austria, 1100
        • Klinik Favoriten
      • Vienna, Austria, 1160
        • Klinik Ottakring
      • Vienna, Austria, 1190
        • Imed 19- privat
      • Vienna, Austria, A 1190
        • Imed 19- privat
  • Belgium
      • Aalst, Belgium, 9300
        • AZORG Aalst - Moorselbaan
      • Brussels, Belgium, 1090
        • UZ Brussel
      • Edegem, Belgium, 2650
        • UZA - UZ Antwerpen - Cardiology Department
      • Genk, Belgium, 3600
        • Ziekenhuis Oost-Limburg
      • Kortrijk, Belgium, 8500
        • AZ Groeninge - Kortrijk - Cardiology
      • Liège, Belgium, 4000
        • CHR de la Citadelle
  • Bosnia and Herzegovina
      • Banja Luka, Bosnia and Herzegovina, 78000
        • University Clinical Centre of the Republic Srpska
      • Sarajevo, Bosnia and Herzegovina, 71000
        • University Clinical Centre Sarajevo
      • Sarajevo, Bosnia and Herzegovina, 71000
        • Dr. Abdulah Nakas General Hospital
  • Brazil
      • Aracaju, Brazil, 49055-530
        • Jmf Clínica Do Coração Ltda
      • Goiânia/GO, Brazil, 74605-020
        • Hospital de Clínicas da Universidade Federal de Goiânia
      • Marília/SP, Brazil, 17515-000
        • ICM - Instituto do Coração de Marília
      • Porto Alegre/RS, Brazil, 90840-440
        • Hospital Mãe de Deus - Porto Alegre
      • Recife/PE, Brazil, 56517-630
        • PROCAPE
      • Rio de Janeiro, Brazil, 22061-080
        • Hospital São Lucas Copacabana
      • Rio de Janeiro, Brazil, 22281-100
        • Instituto D'Or de Pesquisa e Ensino
      • São Paulo/SP, Brazil, 04026-090
        • Universidade Federal de São Paulo - UNIFESP
    • Espírito Santo
      • Vitória, Espírito Santo, Brazil, 29055-450
        • Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30220-140
        • NUPEC Cardio
      • Belo Horizonte, Minas Gerais, Brazil, 30150-320
        • CCIH-Consultoria em Controle de Infecção Hospitalar Ltda
      • Uberlândia, Minas Gerais, Brazil, 38400-500
        • Eurolatino Medical Research Center
    • Paraná
      • Campina Grande do Sul, Paraná, Brazil, 83430-000
        • Sociedade Hospitalar Angelina Caron, Brazil
      • Curitiba, Paraná, Brazil, 80230-130
        • PUCPR - Pontificia Universidade Catolica do Parana
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-003
        • Hospital de Clinicas de Porto Alegre
    • São Paulo
      • Bragança Paulista, São Paulo, Brazil, 12916-542
        • Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
      • Campinas, São Paulo, Brazil, 13060-080
        • Instituto de Pesquisa clinica de Campinas
      • Campinas, São Paulo, Brazil, 13092-133
        • i9 Pesquisas Clínicas
      • Campinas, São Paulo, Brazil, 13060-803
        • PUCCAMP - Hospital e Maternidade Celso Pierro
      • Ribeirão Preto, São Paulo, Brazil, 14051-140
        • Unidade de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
      • São José do Rio Preto, São Paulo, Brazil, 15090-000
        • CIP Centro Integrado de Pesquisas do Hospital de Base
      • Tatuí, São Paulo, Brazil, 18270-170
        • Instituto de Moléstias Cardiovasculares de Tatuí Ltda
      • Votuporanga, São Paulo, Brazil, 15500-269
        • Integral Pesquisa e Ensino
  • Bulgaria
      • Burgas, Bulgaria, 8000
        • MHAT Heart and Brain EAD - Burgas, Cardiology
      • Kardzhali, Bulgaria, 6600
        • Medical Centre - Avitsena EOOD
      • Kozloduy, Bulgaria, 3320
        • Medical centre "Zdrave 1" OOD
      • Kozloduy, Bulgaria, 3320
        • Medical centre Zdrave 1 OOD
      • Kyustendil, Bulgaria, 2500
        • Medical Centre Hera - Kyustendil EOOD
      • Lom, Bulgaria, 3600
        • DCC 1 - Lom EOOD
      • Lom, Bulgaria, 3600
        • Diagnostic Consulting Center 1- Lom EOOD
      • Panagyurishte, Bulgaria, 4500
        • "MHAT - UniHospital" OOD
      • Panagyurishte, Bulgaria, 4500
        • MHAT - Uni Hospital OOD
      • Pleven, Bulgaria, 5800
        • Medical Center Medconsult Pleven OOD
      • Pleven, Bulgaria, 5800
        • UMHAT - Dr. Georgi Stranski EAD
      • Pleven, Bulgaria, 5804
        • MHAT Heart and Brain EAD - Pleven, Cardiology
      • Plovdiv, Bulgaria, 4002
        • UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
      • Plovdiv, Bulgaria, 4002
        • UMHAT - Plovdiv AD
      • Plovdiv, Bulgaria, 4004
        • MHAT Sveta Karidad EAD
      • Sandanski, Bulgaria, 2800
        • MC Health Care OOD, Sandanski
      • Sevlievo, Bulgaria, 5400
        • 'Medical Center Hipokrena' EOOD
      • Sevlievo, Bulgaria, 5400
        • Medical Center Hipokrena EOOD
      • Sliven, Bulgaria, 8801
        • Medical Centre Cardiomed 2020 EOOD
      • Sofia, Bulgaria, 1233
        • NMTH Tsar Boris III
      • Sofia, Bulgaria, 1431
        • DCC Aleksandrovska EOOD
      • Sofia, Bulgaria, 1527
        • Medical center ISUL - Tsaritsa Yoanna EOOD
      • Sofia, Bulgaria, 1404
        • MHAT Sveta Sofia EOOD
      • Sofia, Bulgaria, 1202
        • DCC Ascendent OOD
      • Sofia, Bulgaria, 1233
        • MHAT Knyaginya Klementina - Sofia EAD
      • Sofia, Bulgaria, 1680
        • Medical Centre Intermedica OOD
      • Stara Zagora, Bulgaria, 6000
        • Medical center Zara-Med EOOD
      • Veliko Tarnovo, Bulgaria, 5006
        • MC Nevromedics EOOD, Cardiology
      • Veliko Tarnovo, Bulgaria, 5000
        • MDHAT Dr. Stephen Cherkezov AD
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 4Z6
        • University of Calgary_Calgary
      • Edmonton, Alberta, Canada, T5A 4L8
        • Alta Clinical Research
    • British Columbia
      • New Westminster, British Columbia, Canada, V3L 3W4
        • Royal Columbian Hospital
      • North Vancouver, British Columbia, Canada, V7M 2H4
        • North Shore Heart Centre
      • Surrey, British Columbia, Canada, V3V 0C6
        • SMH Cardiology Clinical Trials Inc.
      • Vancouver, British Columbia, Canada, V6Z1Y6
        • St Pauls Hospital
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Ctr for Cardiovascular Innovation
      • Victoria, British Columbia, Canada, V8R 1B2
        • Victoria Heart Institute Foundation
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2H 2HA6
        • St. Boniface Hospital
    • New Brunswick
      • Moncton, New Brunswick, Canada, E1G 1A7
        • G.A. Research Associates Ltd.
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 3A7
        • Nova Scotia Health
    • Ontario
      • Cambridge, Ontario, Canada, N1R 6V6
        • Cambridge Cardiac Care Centre
      • Cambridge, Ontario, Canada, N1R 7R1
        • Saul Vizel Pro. Med. Corp
      • Greater Sudbury, Ontario, Canada, P3E 5J1
        • Health Sciences North Rsrch Inst
      • Guelph, Ontario, Canada, N1H 1B1
        • Dawson Clinical Research
      • Hamilton, Ontario, Canada, L8L 2X2
        • Hamilton Hlth Sc. - General Site
      • London, Ontario, Canada, N6A 4V2
        • St. Joseph's Hospital
      • Newmarket, Ontario, Canada, L3Y 2P6
        • Partnrs Adv Cardio Eval (PACE)
      • North York, Ontario, Canada, M6B 3H7
        • North York Diagn & Cardiac Ctr
      • Oshawa, Ontario, Canada, L1J 2K9
        • Centricity Research Oshawa
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials
      • Toronto, Ontario, Canada, M6G 1M2
        • Diabetes Heart Research Centre
      • Toronto, Ontario, Canada, M5S 1B1
        • Women's College Hospital
      • Toronto, Ontario, Canada, M5B 1W8
        • St. Michael's - Division of Cardiology
      • Waterloo, Ontario, Canada, N2T 0C1
        • CPS Research
      • Waterloo, Ontario, Canada, N2T 0C1
        • Clinical Research Solutions Inc.
      • Winchester, Ontario, Canada, K0C 2K0
        • Winchester Dist Memorial Hosp
    • Quebec
      • Longueuil, Quebec, Canada, J4H4B9
        • Viacar Recherche Clinique Inc.
      • Montreal, Quebec, Canada, H1T 1C8
        • Institut de Cardiologie de Montreal
      • Montreal, Quebec, Canada, H2X 0C1
        • CHU de Montréal
      • Saint-Jean-sur-Richelieu, Quebec, Canada, J3A 1J2
        • CardioVasc HR Inc
      • Sherbrooke, Quebec, Canada, J1G 2E8
        • CIUSSS de l'E CHUS_Sherbrooke
      • Terrebonne, Quebec, Canada, J6X 4P7
        • Ctr de méd métab de Lanaudière
      • Terrebonne, Quebec, Canada, J6V 2H2
        • CISSSL Hôsp Pierre-Le Gardeur
      • Trois-Rivières, Quebec, Canada, G9A 4P3
        • Diex Recherche Trois-Rivieres
    • Saskatchewan
      • Saskatoon, Saskatchewan, Canada, S7N 0W8
        • Royal University Hospital
  • China
      • Chongqing, China, 404000
        • Chongqing University Three Gorges Hospital
      • Shanghai, China, 20031
        • Shanghai Xuhui Central Hospital
    • Anhui
      • Huainan, Anhui, China, 232007
        • The First Hospital of Anhui University of Science & Technology (Huainan First People's Hospital)-Cardiology
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100029
        • China-Japan Friendship Hospital
      • Beijing, Beijing Municipality, China, 100029
        • Beijing Anzhen Hospital, Capital Medical University
      • Beijing, Beijing Municipality, China, 100037
        • Chinese Academy of Medical Sciences Fuwai Hospital
      • Beijing, Beijing Municipality, China, 100191
        • Peking University Third Hospital-Cardiology
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 404000
        • Chongqing University Three Gorges Hospital
      • Chongqing, Chongqing Municipality, China, 400042
        • The First Affiliated Hospital of Chongqing Medical University-Cardiology
      • Chongqing, Chongqing Municipality, China, 400060
        • The Second Affiliated Hospital of Chongqing Medical University
    • Gansu
      • Lanzhou, Gansu, China, 730030
        • The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular
    • Guangdong
      • Guangzhou, Guangdong, China, 510120
        • Sun Yat-sen Memorial Hospital, Sun Yat-sen University
      • Guangzhou, Guangdong, China, 510630
        • The First Affiliated Hospital of Jinan University
      • Guangzhou, Guangdong, China, 510120
        • Sun Yat-sen Memorial Hospital, Sun Yat-sen Universtiy
      • Shantou, Guangdong, China, 515041
        • The Second Affiliated Hospital of Shantou University Medical College-Cardiovascular
      • Shenzhen, Guangdong, China, 518020
        • ShenZhen People's Hospital
    • Guangxi
      • Nanning, Guangxi, China, 530021
        • The People's Hospital of Guangxi Zhuang Autonomous Region
    • Hainan
      • Haikou, Hainan, China, 570311
        • Hainan General Hospital
    • Hebei
      • Shijiazhuang, Hebei, China, 050051
        • Hebei General Hospital
      • Shijiazhuang, Hebei, China, 050023
        • The First Hospital of Hebei Medical University-Cardiovascular
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150001
        • The First Affiliated Hospital of Harbin Medical University-Cardiovascular
    • Hubei
      • Wuhan, Hubei, China, 430060
        • Renmin Hospital of Wuhan University-Cardiology
      • Wuhan, Hubei, China, 430022
        • Wuhan Asia Heart Hospital-Department of Cardiovascular
    • Hunan
      • Changsha, Hunan, China, 410013
        • The Third Xiangya Hospital of Central South University
      • Changsha, Hunan, China, 410028
        • Changsha Central Hospital
    • Jiangsu
      • Changzhou, Jiangsu, China, 213004
        • The First People's Hospital of Changzhou
      • Changzhou, Jiangsu, China, 213003
        • Changzhou No.2 People's Hospital, Yanghu Branch
      • Huai'an, Jiangsu, China, 223300
        • Huai'an First People's Hospital, Nanjing Medical University
      • Nanjing, Jiangsu, China, 210009
        • Zhongda Hospital Southeast University
      • Nanjing, Jiangsu, China, 210011
        • The Second Affiliated Hospital of Nanjing Medical University
      • Suzhou, Jiangsu, China, 215000
        • The First Affiliated Hospital of Soochow University
      • Xuzhou, Jiangsu, China, 221002
        • The Affiliated Hospital of Xuzhou Medical University-Cardiology
      • Yangzhou, Jiangsu, China, 225001
        • Northern Jiangsu People's Hospital
      • Zhenjiang, Jiangsu, China, 212001
        • The Affiliated Hospital of Jiangsu University
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • The Second Affiliated Hospital of Nanchang University-Cardiology
    • Jilin
      • Changchun, Jilin, China, 130033
        • China-Japan Union Hospital of Jilin University-Cardiology
      • Changchun, Jilin, China, 130499
        • Jilin Province People's Hospital-Cardiology
      • Siping, Jilin, China, 136000
        • Siping Central People's Hospital-Cardiology
    • Liaoning
      • Shenyang, Liaoning, China, 110016
        • The People's Hospital of Liaoning Province-Cardiology
    • Ningxia
      • Yinchuan, Ningxia, China, 750004
        • General Hospital of Ningxia Medical University
    • Shaanxi
      • Xi'an, Shaanxi, China, 710061
        • The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
      • Xi'an, Shaanxi, China, 710068
        • Shaanxi Provincial People's Hospital-Cardiology
    • Shandong
      • Jining, Shandong, China, 272029
        • The Affiliated Hospital of Jining Medical University-Cardiology
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200040
        • Huashan Hospital Fudan University
      • Shanghai, Shanghai Municipality, China, 200031
        • Shanghai Xuhui Central Hospital
      • Shanghai, Shanghai Municipality, China, 200065
        • Tongji Hospital of Tongji University-Cardiology
    • Sichuan
      • Mianyang, Sichuan, China, 621000
        • Mianyang Central Hospital-Cardiology
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300222
        • Tianjin Chest Hospital
      • Tianjin, Tianjin Municipality, China, 300121
        • Tianjin Union Medical Center
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310014
        • Zhejiang Provincial People's Hospital
      • Hangzhou, Zhejiang, China, 310003
        • The First Affiliated Hospital of Zhejiang University School of Medicine
      • Lishui, Zhejiang, China, 323000
        • Lishui People's Hospital
      • Lishui, Zhejiang, China, 323000
        • Lishui People's Hospital-Cardiology
      • Wenzhou, Zhejiang, China, 325000
        • The First Affiliated Hospital of WMU-Cardiology
  • Colombia
      • Barranquilla, Colombia, 080020
        • Fundacion del Caribe para la Investigacion Biomedica-BIOS
      • Barranquilla, Colombia, 080020
        • Corazón IPS S.A.S
      • Bogotá, Colombia, 110111
        • Fundacion Santa Fe de Bogota
      • Medellín, Colombia, 050021
        • Promotora Medica Las Americas S.A.
      • Medellín, Colombia, 050034
        • CardiovidCentro Cardiovascular Colombiano ClinicaSantaMaria
    • Antioquia
      • Medellín, Antioquia, Colombia, 050015
        • Hospital General de Medellin
      • Medellín, Antioquia, Colombia, 050021
        • Rodrigo Botero S.A.S
    • Atlántico
      • Barranquilla, Atlántico, Colombia, 080001
        • IPS Centro Cientifico Asistencial Jose Luis Accini SAS
      • Barranquilla, Atlántico, Colombia, 80020
        • Clinica De La Costa
    • Barranquilla
      • Soledad, Barranquilla, Colombia, 83001
        • Fundación Hospital Universidad del Norte
    • Caldas Department
      • Manizales, Caldas Department, Colombia, 170003
        • IPS Medicos Internistas de Caldas S.A.S.
    • Cundinamarca
      • Chía, Cundinamarca, Colombia, 250001
        • Centro de Atención e Investigación Médica S.A.S. (CAIMED SAS)
    • Santander Department
      • Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, Colombia, 681012
        • Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760036
        • Clinica Imbanaco SAS
  • Croatia
      • Karlovac, Croatia, 47000
        • Opca bolnica Karlovac
      • Karlovac, Croatia, 47000
        • Opca bolnica Karlovac_Cardiology
      • Osijek, Croatia, 31 000
        • Klinicki Bolnicki Centar Osijek_Cardiology
      • Rijeka, Croatia, 51000
        • Specijalna Bolnica Medico
      • Rijeka, Croatia, 51000
        • Clinical Hospital Centre Rijeka_Cardiology
      • Split, Croatia, 21 000
        • KBC Split_Cardiology
      • Zagreb, Croatia, 10 000
        • University Hospital Sveti Duh
      • Zagreb, Croatia, 10000
        • Poliklinika Magnolija d.o.o.
      • Čakovec, Croatia, 40000
        • Zupanijska bolnica Cakovec
      • Čakovec, Croatia, 40000
        • Poliklinika Medikol_Cakovec_Cardiology
      • Čepin, Croatia, 31431
        • Internacionalni medicinski centar PRIORA
    • City of Zagreb
      • Zagreb, City of Zagreb, Croatia, 10000
        • Poliklinika Solmed
      • Zagreb, City of Zagreb, Croatia, 10000
        • KB Dubrava, Zavod za bolesti srca i krvnih zila
      • Zagreb, City of Zagreb, Croatia, 10 000
        • Poliklinika Aritmija
      • Zagreb, City of Zagreb, Croatia, 10 000
        • University hospital centre Zagreb
    • Krapinsko Zagorska County
      • Krapinske Toplice, Krapinsko Zagorska County, Croatia, 49217
        • Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology
  • Czechia
      • Brno, Czechia, 602 00
        • Kardiologie MUDr. Libor Nechvátal s.r.o.
      • Brno, Czechia, 639 00
        • Amkardia s.r.o.
      • Hradec Králové, Czechia, 50005
        • FN Hradec Kralove
      • Liberec, Czechia, 460 02
        • KARDIOLOGIE - LIBEREC s.r.o.
      • Liberec, Czechia, 460 01
        • KARDIOLOGIE - LIBEREC s.r.o.
      • Plzen - Lochotín, Czechia, 323 00
        • Fakultni nemocnice Plzen - Lochotin
      • Polička, Czechia, 572 01
        • Policska nemocnice
      • Polička, Czechia, 572 01
        • Poličská nemocnice s.r.o.
      • Prague, Czechia, 120 00
        • Fakultní poliklinika VFN ambulance Srdecniho selhani
      • Prague, Czechia, 110 00
        • Kardiologická a interní ambulance
      • Prague, Czechia, 110 00
        • Kardiologie Vinohrady s.r.o.
      • Slaný, Czechia, 274 01
        • Nemocnice Slaný
      • Slaný, Czechia, 274 01
        • Nemocnice Slany Kardiologie
      • Trutnov, Czechia, 541 01
        • Kardiologicka ambulance MUDr. Ferkl s.r.o.
      • Tábor, Czechia, 39003
        • Vseobecna kardiologicka ambulance
      • Tábor, Czechia, 39003
        • Všeobecná kardiologická ambulance s.r.o.
      • Uherské Hradiště, Czechia, 68601
        • Clinical Trials Service s.r.o.
  • Denmark
      • Aarhus N, Denmark, 8200
        • Aarhus Universitetshospital, Skejby Hjertesygdomme
      • Aarhus N, Denmark, 8200
        • Aarhus Universitetshospital, Hjertesygdomme
      • Frederiksberg, Denmark, 2000
        • Bispebjerg og Frederiksberg Hospital
      • Roskilde, Denmark, 4000
        • Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling
    • Capital Region
      • Herlev, Capital Region, Denmark, 2730
        • Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1
    • Region South
      • Svendborg, Region South, Denmark, 5700
        • Kardiologisk Odense & Svendborg
      • Svendborg, Region South, Denmark, 5700
        • Svendborg Sygehus - Kardiologisk
  • Estonia
      • Tallinn, Estonia, 10138
        • East Tallinn Central Hospital
      • Tallinn, Estonia, 13419
        • North Estonia Medical Centre Foundation
      • Tartu, Estonia, 50406
        • Tartu University Hospital
  • Finland
      • Helsinki, Finland, 00290
        • HUS Cardiac and Lung Unit CRC
      • Jyväskylä, Finland, 40620
        • StudyCor
      • Kuopio, Finland, 70600
        • Health Step Finland Oy
      • Seinäjoki, Finland, 60220
        • Seinäjoen keskussairaala
      • Tampere, Finland, 33520
        • TAYS Sydänsairaala
      • Turku, Finland, 20520
        • TYKS Cardiac Unit
  • France
      • La Tronche, France, 38700
        • Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon
      • Montpellier, France, 34295
        • Hôpital Arnaud de Villeneuve_Service de Cardiologie
      • Paris, France, 75010
        • Aphp-Hopital Lariboisiere
      • Paris, France, 75013
        • APHP-HOPITAL LA PITIE SALPETRIERE_Institut de Cardiologie
      • Pau, France, 64000
        • Centre Hospitalier de Pau - Hôpital François Mitterrand
      • Poitiers, France, 86000
        • Centre Hospitalier Universitaire De Poitiers
      • Poitiers, France, 86000
        • CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS - Centre Cardio Vasculaire
      • Toulon, France, 83100
        • Centre Hospitalier Intercommunal Toulon La Seine-Sur-Mer - Hopital Sainte Musse
      • Toulouse, France, 31059
        • CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL_Service de Cardiologie
      • Vandœuvre-lès-Nancy, France, 54500
        • Chru de Nancy - Hopital Brabois
  • Germany
      • Aachen, Germany, 52074
        • Uniklinik Aachen - Med. Klinik I
      • Berlin, Germany, 13353
        • Charite Universitatsmedizin Berlin KöR
      • Berlin, Germany, 13353
        • Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)
      • Berlin, Germany, 10787
        • Velocity - Clinical Research Germany GmbH Berlin
      • Bielefeld, Germany, 33604
        • Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin
      • Bochum, Germany, 44791
        • Kath. Klinikum Bochum gGmbH - St. Josef-Hospital Kardiologie
      • Bremen, Germany, 28277
        • Kardiologisch-Angiologische Praxis Herzzentrum Bremen
      • Dortmund, Germany, 44137
        • Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie
      • Dresden, Germany, 01307
        • Uniklinik TU Dresden - Herzzentrum Dresden GmbH
      • Dresden, Germany, 01277
        • Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
      • Dresden, Germany, 01099
        • Facharztzentrum Dresden Betriebsgesellschaft mbH
      • Elsterwerda, Germany, 04910
        • Zentrum für klinische Studien Südbrandenburg GmbH
      • Frankfurt, Germany, 60389
        • MVZ CCB Frankfurt und Main-Taunus GbR
      • Frankfurt am Main, Germany, 60596
        • Universitätsklinikum Frankfurt aM - Kardiologie
      • Freiburg im Breisgau, Germany, 79106
        • Universitätsklinikum Freiburg - Medical Center
      • Giessen, Germany, 35392
        • Justus-Liebig-Universität Gießen - Kardiologie
      • Göttingen, Germany, 37075
        • Uni-Med. Göttingen - Kardiologie, Pneumologie
      • Hamburg, Germany, 20251
        • University Medical Center Hamburg-Eppendorf
      • Hamburg, Germany, 20246
        • Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf
      • Haßloch, Germany, 67454
        • Kardiologie Haßloch
      • Homburg, Germany, 66421
        • Universität des Saarlandes - Innere Med. III
      • Jena, Germany, 07747
        • Uniklinik Jena - Kardiologie
      • Kaiserslautern, Germany, 67655
        • Kardiopraxis Schirmer
      • Leipzig, Germany, 04103
        • Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie
      • Mainz, Germany, 55116
        • Gesundheitscentrum Mainz (Regner / Schmitt)
      • Mannheim, Germany, 68165
        • zero PRAXEN Mannheim-Schwetzingerstadt
      • München, Germany, 81377
        • LMU Klinikum München Klinik und Poliklinik 1
      • Papenburg, Germany, 26871
        • Kardiologische Gemeinschaftspraxis Papenburg
      • Rotenburg A.d. Fulda, Germany, 36199
        • Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg GmbH
      • Wermsdorf, Germany, 04779
        • Al-Zoebi
      • Würzburg, Germany, 97078
        • Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz
  • Greece
      • Ampelokipoi/Athens, Greece, 11522
        • General Hospital of Athens "Elpis" - Cardiology Department
      • Athens, Greece, 11527
        • Hippokration Hospital
      • Athens, Greece, GR-15123
        • "Hygeia" General Hospital of Athens
      • Athens, Greece, 15125
        • Iatriko Athinon (Athens Medical Canter)
      • Athens, Greece, 14233
        • Konstantopouleio G.H. of Athens, "Agia Olga"
      • Athens, Greece, 15123
        • "Hygeia" General Hospital of Athens
      • Athens, Greece, 11527
        • Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
      • Athens, Greece, 11527
        • 'G. Gennimatas' General Hospital of Athens - Cardiology Department
      • Athens, Greece, GR-11527
        • Genl Hospital of Athens Ippokrateio,A' Cardiology Univ dpt
      • Chaidari, Athens, Greece, 12462
        • U.G.H of Athens "Attikon"
      • Chalcis, Greece, 34100
        • General Hospital of Kalamata - Cardiology Department
      • Chios, Greece, 82100
        • General Hospital of Chios "Skilitsio" - Cardiology Clinic
      • Heraklion, Greece, 71409
        • General Hospital Venizeleio-Pananeio - Cardiology department
      • Heraklion, Greece, 71409
        • Venizeleio Pananeio
      • Kalamata, Greece, 24100
        • General Hospital of Kalamata
      • Kalamata, Greece, 24100
        • General Hospital of Kalamata - Cardiology Department
      • Kifissia, Greece, 14564
        • General Oncological Hospital of Kifissia Agioi Anargyroi - Cardiology Clinic
      • Larissa, Greece, 41110
        • Univ Gen Hospital Larisa, Cardiology Medicine Clinic
      • Mytilene, Greece, 81132
        • General Hospital Of Mytilene Vostanio - Cardiology Department
      • Piraeus, Greece, 18536
        • Geniko Nosokomeio Peiraia Tzaneio - Cardiology department
      • Pylea, Thessaloniki, Greece, 57001
        • Iatriko Athinon (Athens Medical Canter)
      • Rio Patras, Greece, 26504
        • General University Hospital of Patras
      • Rio Patras, Greece, GR26504
        • General University Hospital of Patras
      • Thessaloniki, Greece, 54636
        • "AHEPA" University General Hospital of Thessaloniki
      • Thessaloniki, Greece, 54642
        • 'Ippokrateio' General Hospital of Thessaloniki
      • Thessaloniki, Greece, 54635
        • General Hospital of Thessaloniki 'G. Gennimatas - Cardiology Department
    • Attica
      • Athens, Attica, Greece, 11528
        • Alexandra General Hospital, Therapeutic Clinic
      • Athens, Attica, Greece, GR11528
        • Alexandra General Hospital, Therapeutic Clinic
    • Crete
      • Heraklion, Crete, Greece, 71500
        • University General Hospital Of Heraklion - Cardiology Department
  • Hungary
      • Baja, Hungary, 6500
        • EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
      • Balatonfüred, Hungary, 8230
        • Tagore Medical Center
      • Balatonfüred, Hungary, 8230
        • DRC Kft.
      • Budapest, Hungary, 1204
        • Jahn Ferenc Del-pesti Korhaz es Rendelointezet
      • Budapest, Hungary, 1096
        • Gottsegen György Országos Kardiológiai Intézet
      • Budapest, Hungary, 1122
        • Semmelweis Egyetem Városmajori Szív- és Érgyógyászat
      • Budapest, Hungary, 1134
        • Észak-Pesti Centrumkórház Honvédkórház
      • Budapest, Hungary, 1023
        • Betegápoló Irgalmasrend, Budai Irgalmasrendi Kórház
      • Gyula, Hungary, 5700
        • Bekes Varmegyei Kozponti Korhaz
      • Miskolc, Hungary, 3526
        • Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
      • Pécs, Hungary, 7623
        • Coromed SMO Kft.
      • Szeged, Hungary, 6725
        • Szegedi Tudományegyetem
    • Baranya
      • Pécs, Baranya, Hungary, 7624
        • PTE ÁOK I. sz. Belgyógyászati Klinika
    • Bekes County
      • Békéscsaba, Bekes County, Hungary, 5600
        • Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
      • Gyula, Bekes County, Hungary, 5700
        • Bekes Varmegyei Kozponti Korhaz
      • Orosháza, Bekes County, Hungary, 5900
        • Arina Trial Research Kft.
    • Bács-Kiskun county
      • Baja, Bács-Kiskun county, Hungary, 6500
        • Lausmed Kft.
    • Csongrád-Csanád
      • Szeged, Csongrád-Csanád, Hungary, 6725
        • Szegedi Tudományegyetem II. sz Belgyógyászati és Kardiológia
    • Komárom-Esztergom
      • Komárom, Komárom-Esztergom, Hungary, 2921
        • Selye János Kórház
    • Somogy County
      • Kaposvár, Somogy County, Hungary, 7400
        • Somogy Megyei Kaposi Mor Oktato Korhaz
    • Zala County
      • Zalaegerszeg, Zala County, Hungary, 8900
        • Léda Platán Magánklinika
  • India
      • Aligarh, India, 202002
        • Aligarh Muslim University
      • Bengaluru, India, 560054
        • MS Ramaiah
      • Karnataka, India, 590010
        • KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre
      • New Delhi, India, 110075
        • Aakash Healthcare Super Speciality Hospital
      • New Delhi, India, 110055
        • Dr B L Kapur Memorial Hospital
      • New Delhi, India, 110060
        • Sir Ganga Ram Hospital-Cardiology
      • Palakkad, India, 678013
        • Lakshmi Hospital
      • Puducherry, India, 605006
        • JIPMER
    • Andhra Pradesh
      • Guntur, Andhra Pradesh, India, 522001
        • Lalitha Super Specialities Hospital
      • Guntur, Andhra Pradesh, India, 522001
        • Lalitha PVS Institute of Medical Sciences
      • Vijayawada, Andhra Pradesh, India, 520008
        • Ramesh Hospitals
      • Vijayawada, Andhra Pradesh, India, 520008
        • Government Siddhartha Medical College & Government General Hospital, Vijayawada
    • Assam
      • Guwahati, Assam, India, 781006
        • GNRC Hospital
    • Gujarat
      • Ahmedabad, Gujarat, India, 380060
        • Epic Hospital
      • Ahmedabad, Gujarat, India, 380060
        • CIMS- Care Institute of Medical Sciences
      • Ahmedabad, Gujarat, India, 380006
        • Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
      • Ahmedabad, Gujarat, India, 380060
        • Marengo Asia Health Care Private Limited
      • Ahmedabad, Gujarat, India, 38006
        • Sardar Vallabhbhai Patel Institute of Medical Sciences and Research
      • Surat, Gujarat, India, 395002
        • Nirmal Hospital Pvt. Ltd.
      • Surat, Gujarat, India, 395001
        • Shri B. D. Mehta Mahavir Heart Institute
      • Vadodara, Gujarat, India, 390022
        • Rhythm Heart Institute
    • Haryana
      • Gurugram, Haryana, India, 122001
        • Medanta - The Medicity Multi-Speciality Hospital, Gurugram
    • Karnataka
      • Bangalore, Karnataka, India, 560017
        • Manipal Hospital, Old Airport Road, Bengaluru
      • Belagavi, Karnataka, India, 590010
        • KLES Dr. Prabhakar Kore Hospital & Medical Research Centre
      • Bengaluru, Karnataka, India, 560069
        • Sri Jayadeva Institute of Cardiovascular Sciences & Research
      • Bengaluru, Karnataka, India, 560099
        • Narayana Institute of Cardiac Sciences
    • Kerala
      • Kochi, Kerala, India, 682041
        • Amrita Institute of Medical Sciences
      • Kochi, Kerala, India, 682018
        • Lisie Hospital
      • Kozhikode, Kerala, India, 673008
        • Government Medical College, Kozhikode
    • Maharashtra
      • Mumbai, Maharashtra, India, 400012
        • Seth GS medical college and KEM Hospital
      • Nagpur, Maharashtra, India, 440012
        • Shri Krishna Hrudayalaya & Critical Care Centre
      • Nagpur, Maharashtra, India, 440010
        • Arneja Heart & Multispeciality Hospital
      • Nagpur, Maharashtra, India, 440003
        • Government Medical College and Super Speciality Hospital, Nagpur
      • Nagpur, Maharashtra, India, 440033
        • Sengupta Hospital and Research Institute
      • Pune, Maharashtra, India, 411004
        • Sahyadri Clinical Research And Development Center
      • Pune, Maharashtra, India, 411001
        • Jehangir Clinical Development Centre
      • Pune, Maharashtra, India, 411011
        • KEM Hospital
      • Pune, Maharashtra, India, 411001
        • B J Goverment Medical College and Sassoon General Hospital
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • All India Institute Of Medical Sciences (AIIMS)
      • New Delhi, National Capital Territory of Delhi, India, 110002
        • G B Pant Institute of Postgraduate Medical Education and Research
      • New Delhi, National Capital Territory of Delhi, India, 110025
        • Fortis Escorts Heart Institute, New Delhi
    • New Delhi
      • New Dehli, New Delhi, India, 110029
        • VMMC & Safdarjung Hospital
    • Punjab
      • Chandigarh, Punjab, India, 160012
        • Post Graduate Institute of Medical Education & Research_Chandigarh
      • Ludhiana, Punjab, India, 141001
        • Dayanand Medical College & Hospital
      • Ludhiana, Punjab, India, 141002
        • Deep Hospital
      • Mohali, Punjab, India, 160062
        • Fortis Hospital, Mohali
    • Rajasthan
      • Bikaner, Rajasthan, India, 334003
        • S.P. Medical College and A.G. Hospitals
      • Jaipur, Rajasthan, India, 302004
        • SMS Medical College & Attached Hospitals
      • Jaipur, Rajasthan, India, 302001
        • SMS Medical College & Attached Hospitals
      • Jodhpur, Rajasthan, India, 342005
        • All India Institute Of Medical Sciences (AIIMS)
      • Jodhpur, Rajasthan, India, 342005
        • All India Institute of Medical Sciences (AIIMS), Jodhpur
    • Tamil Nadu
      • Chennai, Tamil Nadu, India, 600037
        • The Madras Medical Mission
    • Telangana
      • Hyderabad, Telangana, India, 500012
        • Osmania General Hospital
      • Hyderabad, Telangana, India, 500020
        • Guru Nanak CARE Hospitals
      • Hyderabad, Telangana, India, 500032
        • AIG Hospitals,Hyderabad
      • Hyderabad, Telangana, India, 500 012
        • Osmania General Hospital
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, India, 226003
        • King George's Medical University (KGMU)
    • Uttarakhand
      • Dehradun, Uttarakhand, India, 248001
        • Shri Mahant Indiresh Hospital
    • West Bengal
      • Kolkata, West Bengal, India, 700020
        • IPGME&R and SSKM Hospital
  • Ireland
      • Cork, Ireland, T12 DC4A
        • Cork University Hospital
      • Dublin, Ireland, A96 D628
        • The Heartbeat Trust
      • Dublin, Ireland, D07 KX5K
        • Mater Miscericordiae Hospital
      • Dublin, Ireland, D07KWR1
        • Mater Private Network - Dublin
      • Dublin, Ireland, D08 A978
        • St James's CRF
      • Mahon, Cork, Ireland, T12 K199
        • Mater Private Network Cork
    • Leinster
      • Dublin, Leinster, Ireland, D08 A978
        • St James's CRF
  • Israel
      • Beer Yaakov, Israel, 7033001
        • Shamir MC - Cardiology Department
      • Hadera, Israel, 3810101
        • Hillel Yaffe MC - Cardiology Department
      • Haifa, Israel, 3109601
        • Rambam MC - Heart Failure Unit
      • Jerusalem, Israel, 91120
        • Hadassah Ein Karam MC - Cardio Department
      • Petah Tikva, Israel, 49100
        • Rabin MC Beilinson - Heart Failure Unit
      • Rehovot, Israel, 76100
        • Kaplan MC - Heart Failure Unit
      • Tel Aviv, Israel, 6423906
        • Sourasky MC - Cardio Vascular Research Center
      • Tel Litwinsky, Israel, 5265601
        • Sheba MC - Cardiology Clinical Research Unit
  • Italy
      • Bari, Italy, 70124
        • Fondazione Salvatore Maugeri I.R.C.C.S. - Bari
      • Foggia, Italy, 71122
        • Ospedali riuniti di Foggia
      • Foggia, Italy, 71122
        • Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia
      • Grosseto, Italy, 58100
        • AUSL Toscana Sud Est - Ospedale Misericordia Grosseto
      • Milan, Italy, 20157
        • ASST Fatebenefratelli Ospedale Luigi Sacco Medicina Interna
      • Monza, Italy, 20900
        • Azienda Ospedaliera San Gerardo
      • Naples, Italy, 80131
        • Azienda Ospedaliera Dei Colli - Monaldi - Centro ricerche cardiologiche
      • Naples, Italy, 80131
        • Azienda Ospedaliera di Rilievo Nazionale AORN Dei Colli, "V.Monaldi",
      • Novara, Italy, 28100
        • AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia
      • Pavia, Italy, 27100
        • Fondazione IRCCS Policlinico San Matteo
      • Trieste, Italy, 34128
        • Azienda Sanitaria Univ Giuliano Isontina
      • Trieste, Italy, 34128
        • Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia
    • Al
      • Casale Monferrato, Al, Italy, 15033
        • ASL Al Di Alessandria - Ospedale Santo Spirito - Casale Monferrato - Cardiologia
      • Casale Monferrato, Al, Italy, 15033
        • Ospedale Santo Spirito
    • Bg
      • Bergamo, Bg, Italy, 24127
        • ASST Papa Giovanni XXIII
    • Bn
      • Benevento, Bn, Italy, 82100
        • AORN "San Pio"- Benevento - UOC Cardiologia Interventistica ed UTIC
      • Benevento, Bn, Italy, 82100
        • AORN "San Pio"- Benevento
    • Bs
      • Brescia, Bs, Italy, 25123
        • Spedali Civili Brescia
    • Ce
      • Caserta, Ce, Italy, 81100
        • AORN "Sant'Anna e San Sebastiano"
    • Cz
      • Catanzaro, Cz, Italy, 88100
        • Azienda Ospedaliero-Universitaria Renato Dulbecco
    • Fe
      • Cona (Ferrara), Fe, Italy, 44124
        • A.O.U. Ferrara, Sant'Anna
    • Ge
      • Genova, Ge, Italy, 16132
        • IRCCS Ospedale Policlinico San Martino
    • Lombardy
      • Bergamo, Lombardy, Italy, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
    • Pg
      • Perugia, Pg, Italy, 06129
        • Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia
    • Pi
      • Pisa, Pi, Italy, 56124
        • Fondazione Toscana Gabriele Monasterio - Dipartimento Cardiotoracico - UOC Cardiologia e Medicina Cardiovascolare
      • Pisa, Pi, Italy, 56126
        • Fondazione CNR-Regione Toscana Gabriele Monasterio
    • Rm
      • Roma, Rm, Italy, 00135
        • Azienda Sanitaria Locale Roma 1 - Ospedale San Filippo Neri - Cardiologia Clinica
    • Si
      • Siena, Si, Italy, 53100
        • Azienda Ospedaliera Universitaria Senese
    • To
      • Rivoli, To, Italy, 10098
        • Presidio Ospedaliero di Rivoli
      • Torino, To, Italy, 10128
        • Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia
    • Veneto
      • Treviso, Veneto, Italy, 31100
        • Ospedale Ca' Foncello
    • Vr
      • Verona, Vr, Italy, 37126
        • AOUI Verona
  • Japan
      • Bunkyo-ku, Tokyo, Japan, 113-8655
        • The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
      • Fukuoka, Japan, 810-8539
        • Hamanomachi Hospital_Cardiovascular medicine
      • Fukuoka, Japan, 812-8582
        • Kyushu University Hospital_Cardiovascular Medicine
      • Fukuoka-shi, Fukuoka, Japan, 814-0133
        • Fukuoka University Hospital_Cardiology
      • Gifu, Japan, 503-8502
        • Ogaki Municipal Hospital_Cardiology
      • Hamamatsu-shi, Shizuoka, Japan, 430-0929
        • JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine
      • Himeji-shi, Hyogo, Japan, 670-8560
        • Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
      • Hokkaido, Japan, 078-8211
        • Asahikawa-Kosei General Hospital_Cardiology
      • Hyōgo, Japan, 665-0125
        • Veritas Hospital_Cardiology
      • Ibaraki, Japan, 311-3193
        • National Hospital Organization Mito Medical Center_Cardiovascular medicine
      • Imabari-shi, Ehime, Japan, 799-1592
        • Saiseikai Imabari Hospital_Cardiology
      • Imabari-shi, Ehime, Japan, 799-1592
        • Saiseikai Imabari Hospital
      • Ishikawa, Japan, 920-8530
        • Ishikawa Prefectural Central Hospital_Cardiology
      • Kagawa, Japan, 769-1695
        • Mitoyo General Hospital_Cardiovascular medicine
      • Kagoshima, Japan, 890-8760
        • Kagoshima City Hospital_Cardiovascular Medicine
      • Kanagawa, Japan, 259-1193
        • Tokai University Hospital_Cardiology
      • Kanagawa, Japan, 236-0037
        • Yokohama Minami Kyousai Hospital_Cardiology
      • Kanagawa, Japan, 236-0051
        • Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center_Cardiology
      • Kishiwada-shi, Osaka, Japan, 596-0042
        • Kishiwada Tokushukai Hospital_Cardiology
      • Kitakyushu-shi, Fukuoka, Japan, 806-8501
        • Japan Community Health care Organization Kyushu Hospital_Cardiology
      • Kitakyushu-shi, Fukuoka, Japan, 806-8501
        • JCHO Kyushu Hospital_Cardiology
      • Kyoto, Japan, 604-8401
        • Rakuwakai Marutamachi Hospital_Cardiology
      • Kyoto, Japan, 606-8507
        • Kyoto University Hospital_Cardiovascular Medicine
      • Mie, Japan, 510-8561
        • Mie Prefectural General Medical Center_Cardiology
      • Miyagi, Japan, 980-0803
        • KKR Tohoku Kosai Hospital_Cardiology
      • Miyagi, Japan, 983-8512
        • Tohoku Medical and Pharmaceutical University Hospital_Division of Cardiology
      • Miyagi, Japan, 983-8520
        • National Hospital Organization Sendai Medical Center_Cardiovascular medicine
      • Morioka-shi, Iwate, Japan, 020-0066
        • Iwate Prefectural Central Hospital
      • Morioka-shi, Iwate, Japan, 020-0066
        • Iwate Prefectural Central Hospital_Cardiology
      • Nagasaki, Japan, 850-8555
        • Nagasaki Harbor Medical Center_Cardiovascular medicine
      • Okayama, Japan, 700-8557
        • Okayama City General Medical Center Okayama City Hospital_Cardiovascular Medicine
      • Okayama, Japan, 701-1154
        • Okayama Medical Center_Cardiology
      • Okayama-shi, Okayama, Japan, 700-8558
        • Okayama University Hospital_Cardiovascular Medicine
      • Osaka, Japan, 564-0013
        • Saiseikai Suita Hospital_Cardiovascular Medicine
      • Osaka, Japan, 565-0871
        • Osaka University Hospital_Cardiovascular medicine
      • Osaka, Japan, 581-0011
        • Yao Tokushukai General Hospital_Cardiovascular division
      • Osaka, Japan, 540-0006
        • National Hospital Organization Osaka National Hospital_Cardiovascular Division
      • Osaka, Japan, 564-8565
        • National Cerebral and Cardiovascular Center Hospital_Department of Heart Failure
      • Osaka, Japan, 565-0871
        • The University of Osaka Hospital_Cardiovascular medicine
      • Saga, Japan, 840-8571
        • Saga-ken Medical Centre Koseikan_Cardiology
      • Shizuoka, Japan, 436-8555
        • Chutoen General Medical Center_Cardiology
      • Takamatsu-shi, Kagawa, Japan, 760-8557
        • Kagawa Prefectural Central Hospital_Cardiovascular Medicine
      • Tokyo, Japan, 140-8522
        • Tokyo Shinagawa Hospital_Cardiovascular Medicine
      • Tokyo, Japan, 103-0027
        • Tokyo-Eki Center-building Clinic_Internal Medicine
      • Tokyo, Japan, 113-8431
        • Juntendo University Hospital_Cardiology
      • Tokyo, Japan, 160-8582
        • Keio University Hospital_Cardiology
      • Tottori, Japan, 683-8504
        • Tottori University Hospital_Cardiovascular Medicine
      • Toyama, Japan, 930-0194
        • Toyama University Hospital_Internal Medicine 2
      • Yamaguchi, Japan, 740-8510
        • National Hospital Organization Iwakuni Clinical Center_Cardiovascular Medicine
      • Yamaguchi, Japan, 745-8522
        • JCHO Tokuyama Community Health Center_Department of Cardiology
      • Yokohama-shi, Kanagawa, Japan, 234-0054
        • Saiseikai Yokohamashi Nanbu Hospital_Cardiology
    • Ehime
      • Uwajima-shi, Ehime, Japan, 798-8510
        • Uwajima City Hospital_Cardiology
    • Kanagawa
      • Yokohama, Kanagawa, Japan, 227-8501
        • Showa University Fujigaoka Hospital_Cardiology
  • Latvia
      • Jelgava, Latvia, 3001
        • Zemgales diabetes centre
      • Riga, Latvia, 1002
        • P. Stradins Clinical University hospital
      • Riga, Latvia, 1001
        • Riga 1st Hospital
      • Riga, Latvia, 1011
        • Adoria
      • Riga, Latvia, 1079
        • Riga East Clinical University Hospital - Clinic "Gailezers"
      • Riga, Latvia, 1013
        • Professor Skride Heart Clinic
      • Riga, Latvia, 1023
        • GK Neiroklinika
      • Riga, Latvia, 1039
        • Veselibas centru apvieniba
    • South Kurzeme Municipality
      • Grobiņa, South Kurzeme Municipality, Latvia, 3430
        • Zane Lucane GP Practice
  • Lithuania
      • Kaunas, Lithuania, 50161
        • Hospital of Lithuanian University of Health Sciences Kauno klinikos
      • Kaunas, Lithuania, 49387
        • Klinikiniai sprendimai, Kaunas
      • Kaunas, Lithuania, 49449
        • JSC "Saules seimos medicinos centras"
      • Kaunas, Lithuania, 45130
        • Kaunas Hospital of the Lithuanian University of Health Sciences
      • Klaipėda, Lithuania, 92288
        • Klaipeda University Hospital
      • Klaipėda, Lithuania, LT-92288
        • Klaipeda University Hospital
      • Klaipėda, Lithuania, 91131
        • Cardiology and Rehabilitation Clinic
      • Vilnius, Lithuania, 08661
        • Vilnius University Hospital Santaros Klinikos
      • Vilnius, Lithuania, 08406
        • JSC Inlita Santaros
      • Šiauliai, Lithuania, 76206
        • Republican Siauliai Hospital Consulting Outpatient Clinic
  • Malaysia
      • Kajang, Malaysia, 43000
        • Hospital Serdang
      • Kuala Lumpur, Malaysia, 50586
        • Hospital Kuala Lumpur
    • Johor
      • Johor Bahru, Johor, Malaysia, 80100
        • Hospital Sultanah Aminah
    • Kedah
      • Alor Star, Kedah, Malaysia, 05460
        • Hospital Sultanah Bahiyah
    • Kelantan
      • Kota Bharu, Kelantan, Malaysia, 16150
        • Hospital Universiti Sains Malaysia
    • Kuala Lumpur
      • Cheras, Kuala Lumpur, Malaysia, 56000
        • Hospital Universiti Kebangsaan Malaysia
      • Cheras, Kuala Lumpur, Malaysia, 56000
        • Hospital Canselor Tuanku Muhriz UKM
      • Lembah Pantai, Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
    • Pahang
      • Kuantan, Pahang, Malaysia, 25100
        • Hospital Tengku Ampuan Afzan
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Sarawak Heart Centre
    • Selangor
      • Kajang, Selangor, Malaysia, 43000
        • Hospital Serdang
      • Sungai Buloh, Selangor, Malaysia, 47000
        • Universiti Teknologi MARA, Sungai Buloh Campus
  • Mexico
      • Mexico City, Mexico, 03100
        • Centro de Investigación Biomédica y Farmacéutica S.C.
      • México, Mexico, 10700
        • Centro de Imagen y Tecnologia en Intervención Cardiovascular
    • Aguascalientes
      • Aguascalientes, Aguascalientes, Mexico, 20230
        • Hospital Cardiologica Aguascalientes
    • Estado de Baja California
      • Tijuana, Estado de Baja California, Mexico, 22500
        • CINCAME
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44130
        • Diseño y Planeacion en Investigacion Medica S.C.
    • México, D.F.
      • Mexico City, México, D.F., Mexico, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64060
        • Cardiolink Clin Trials S.C.
      • Monterrey, Nuevo León, Mexico, 64718
        • Eukarya Pharmasite S.C.
      • Monterrey, Nuevo León, Mexico, 64020
        • Internal Medicine Clin Trials
      • San Nicolás de los Garza, Nuevo León, Mexico, 66465
        • Centro de Investigación y Control Metabólico S. C.
    • Querétaro
      • Santiago de Querétaro, Qro., Querétaro, Mexico, 76000
        • Centro de Estudios Clínicos de Querétaro S.C.
    • San Luis Potosí
      • San Luis Potosí City, San Luis Potosí, Mexico, 78200
        • Centro de Atención e Investigación Cardiovascular del Potosí
    • Sinaloa
      • Culiacán, Sinaloa, Mexico, 80230
        • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
      • Culiacán, Sinaloa, Mexico, 80230
        • Centro para el Desarrollo de la Medicina y la Asistencia
    • Veracruz
      • Xalapa, Veracruz, Mexico, 91193
        • Hospital Angeles de Xalapa
  • Netherlands
      • Amsterdam, Netherlands, 1091 AC
        • OLVG Oost
      • Deventer, Netherlands, 7416 SE
        • Deventer Ziekenhuis - Cardiologie
      • Dordrecht, Netherlands, 3318 AT
        • Albert Schweitzer Zkh, Dordwijk
      • Emmen, Netherlands, 7824 AA
        • Treant, Scheper - Cardiologie
      • Enschede, Netherlands, 7512 KZ
        • Medisch Spectrum Twente - Cardiologie
      • Groningen, Netherlands, 9713 GZ
        • UMC Groningen
      • Heerlen, Netherlands, 6419 PC
        • Zuyderland ziekenhuis - Cardiologie
      • Maastricht, Netherlands, 6229 HX
        • Maastricht Universitair Medisch Centrum
      • Nijmegen, Netherlands, 6525 GA
        • Radboudumc
      • Rotterdam, Netherlands, 3015 GD
        • Erasmus MC
      • The Hague, Netherlands, 2545AA
        • Hagaziekenhuis
  • North Macedonia
      • Skopje, North Macedonia, 1000
        • PHI City General Hospital 8th September
      • Skopje, North Macedonia, 1000
        • PHI University Clinic for Cardiology
      • Skopje, North Macedonia, 1000
        • Private Healthcare Institution - Acibadem Sistina Hospital Skopje
  • Norway
      • Bergen, Norway, 5021
        • Haukeland Universitetssykehus
      • Lørenskog, Norway, 1478
        • Akershus Universitetssykehus HF
      • Oslo, Norway, 0372
        • Rikshospitalet - Kardiologisk forskning
      • Oslo, Norway, 0369
        • Colosseumklinikken Medisinske Senter AS
      • Oslo, Norway, 0450
        • Oslo universitetssykehus HF - Ullevål
      • Stavanger, Norway, NO-4011
        • Stavanger Universitetssykehus, Helse Stavanger HF
  • Poland
      • Bełchatów, Poland, 97-400
        • American Heart of Poland S.A.
      • Gliwice, Poland, 44-100
        • Szpital Miejski w Gliwicach Sp. z o.o.
      • Katowice, Poland, 40-568
        • Care Clinic Sp. z o. o.
      • Katowice, Poland, 40-748
        • Vita Longa Sp. z o. o.
      • Katowice, Poland, 40-600
        • Gyncentrum Sp. z o. o.
      • Katowice, Poland, 40-555
        • Kardio Brynow Sp. z o. o.
      • Kluczbork, Poland, 46-200
        • SCANMED Spółka Akcyjna
      • Krakow, Poland, 31-271
        • UniCardia & UniMedica & UniEstetica
      • Krakow, Poland, 30-082
        • Specjalistyczna Praktyka Lekarska L. Bryniarski
      • Krosno, Poland, 38-400
        • Intercard Spolka z ograniczona odpowiedzialnoscia
      • Lodz, Poland, 93-338
        • Instytut Centrum Zdrowia Matki Polki
      • Lodz, Poland, 90-302
        • Santa Sp. z o.o.
      • Lodz, Poland, 91-347
        • Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego,
      • Lublin, Poland, 20-011
        • Clinical Best Solutions Sp. z o.o., Sp. k
      • Miechów, Poland, 32-200
        • Szpital Sw. Anny w Miechowie
      • Ostrów Wielkopolski, Poland, 63-400
        • Jantar Sp. z o.o.
      • Przemyśl, Poland, 37-700
        • Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
      • Rzeszów, Poland, 35-302
        • Korczowski Bartosz Gabinet Lekarski
      • Rzeszów, Poland, 35-111
        • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie
      • Rzeszów, Poland, 35-205
        • EMED Centrum Usług Medycznych Ewa Smialek
      • Sztum, Poland, 82-400
        • American Heart of Poland S.A.
      • Tychy, Poland, 43-100
        • American Heart of Poland S.A.
      • Warsaw, Poland, 04-141
        • Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy
      • Warsaw, Poland, 02-777
        • Polimedica Centrum Badań, Profilaktyki i Leczenia Sp. z o. o.
      • Warsaw, Poland, 04-501
        • Medical Network Sp. z o. o.
      • Łask, Poland, 98-100
        • Szpitale Powiatowe Sp. z o.o.
      • Świnoujście, Poland, 72-600
        • Balticmed Świnoujście Sp. z o. o.
      • Żarów, Poland, 58-130
        • NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
    • Kuyavian-Pomeranian Voivodeship
      • Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
        • Wojewodzki Szpital Zespolony Im.L.Rydygiera W Toruniu
      • Włocławek, Kuyavian-Pomeranian Voivodeship, Poland, 87-800
        • Kardio Life - Tomasz Borkowski
    • Lesser Poland Voivodeship
      • Chrzanów, Lesser Poland Voivodeship, Poland, 32-500
        • American Heart of Poland S.A.
      • Cracow, Lesser Poland Voivodeship, Poland, 30-701
        • MediNess Sp. z o.o.
      • Krakow, Lesser Poland Voivodeship, Poland, 30-701
        • MediNess Sp. z o.o.
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 50-556
        • Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego
      • Wroclaw, Lower Silesian Voivodeship, Poland, 50-981
        • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
      • Wroclaw, Lower Silesian Voivodeship, Poland, 51-134
        • Zdrowie S.C. Agnieszka I Donald Drozdz
    • Masovian Voivodeship
      • Grodzisk Mazowiecki, Masovian Voivodeship, Poland, 05-825
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
      • Warsaw, Masovian Voivodeship, Poland, 00-416
        • Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego
    • Podlaskie Voivodeship
      • Bialystok, Podlaskie Voivodeship, Poland, 15-540
        • Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
      • Bialystok, Podlaskie Voivodeship, Poland, 15-111
        • Panek Med Centrum Leczenia Chorob Naczyn
    • Pomeranian Voivodeship
      • Gdynia, Pomeranian Voivodeship, Poland, 81-157
        • Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
    • Silesian Voivodeship
      • Dąbrowa Górnicza, Silesian Voivodeship, Poland, 41-300
        • American Heart of Poland S.A.
      • Katowice, Silesian Voivodeship, Poland, 40-648
        • Pro Familia Altera Sp. z o.o.
      • Katowice, Silesian Voivodeship, Poland, 40-635
        • Gornoslaskie Centrum Medyczne Im Prof. Leszka Gieca Sląskiego Uniwersytetu Medycznego W Katowicach
      • Ruda Śląska, Silesian Voivodeship, Poland, 41-710
        • Poradnia AKA-MED Centrum Sp. z o.o.
      • Tychy, Silesian Voivodeship, Poland, 43-100
        • American Heart of Poland S.A.
      • Zabrze, Silesian Voivodeship, Poland, 41-800
        • Slaskie Centrum Chorob Serca W Zabrzu
    • Łódź Voivodeship
      • Bełchatów, Łódź Voivodeship, Poland, 97-400
        • American Heart of Poland S.A.
      • Lodz, Łódź Voivodeship, Poland, 90-549
        • Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi
      • Zgierz, Łódź Voivodeship, Poland, 95-100
        • American Heart of Poland S.A.
  • Portugal
      • Alcabideche, Portugal, 2755-009
        • Hospital de Cascais
      • Braga, Portugal, 4710-243
        • ULS De Braga, E.P.E. - Hospital de Braga
      • Figueira da Foz Municipality, Portugal, 3094-001
        • ULS Do Baixo Mondego, E.P.E. - Hospital Distrital Figueira Da Foz
      • Guarda, Portugal, 6301-858
        • ULS Da Guarda E.P.E. - Hospital Sousa Martins
      • Guilhufe - Penafiel, Portugal, 4560-136
        • ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo
      • Leiria, Portugal, 2410-197
        • ULS Da Região De Leiria E.P.E.- Hospital de Santo André
      • Lisbon, Portugal, 1500-650
        • Hospital da Luz
      • Lisbon, Portugal, 1649-035
        • Centro Hospitalar Lisboa Norte
      • Lisbon, Portugal, 1998-018
        • Hospital CUF Descobertas S.A.
      • Lisbon, Portugal, 1500-650
        • Hospital da Luz Lisboa, S.A._Serviço de Medicina Interna
      • Lisbon, Portugal, 1649-035
        • Unidade De Santa Maria E.P.E. - Hospital de Santa Maria
      • Lisbon, Portugal, 1449-005
        • ULS Lisboa Ocidental, E.P.E_Hospital São Francisco Xavier_Hospital de Dia de Especialidades Médicas
      • Porto, Portugal, 4099-001
        • ULS De Santo António, E.P.E. - Hospital de Santo António
      • Santa Maria da Feira, Portugal, 4520-211
        • ULS Entre Douro e Vouga E.P.E. - Hospital São Sebastião
      • Setúbal, Portugal, 2910-446
        • ULS Da Arrábida, E.P.E._Hospital de São Bernardo
      • Setúbal, Portugal, 2900-722
        • Hospital da Luz Setúbal, S.A.
  • Romania
      • Baia Mare, Romania, 430222
        • Cabinet Medical de Cardiologie Dr. Calin Pop
      • Brasov, Romania, 500326
        • Spitalul Clinic Judetean de Urgenta Brasov
      • Brasov, Romania, 500283
        • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
      • Brasov, Romania, 500091
        • S.C. Centrul Medical Unirea S.R.L.
      • Brăila, Romania, 810325
        • Spitalul Judetean de Urgenta Braila
      • Bucharest, Romania, 050098
        • Spitalul Universitar de Urgență București
      • Bucharest, Romania, 011461
        • Spitalul Universitar de Urgență Elias
      • Bucharest, Romania, 010825
        • "Carol Davila" Military Emergency Hospital
      • Bucharest, Romania, 021875
        • Davius Clinicmed Srl
      • Bucharest, Romania, 011053
        • Hightech Medical Services S.R.L.
      • Bucharest, Romania, 012292
        • Lotus Med SRL
      • Bucharest, Romania, 014146
        • Centrul Medical Emerald
      • Bucharest, Romania, 042122
        • Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti
      • Bucharest, Romania, 020339
        • Donna Medplus S.R.L.
      • Bucharest, Romania, 021337
        • Ecocard Srl
      • Bucharest, Romania, 022328
        • Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu
      • Buzău, Romania, 120133
        • Mat Cord Biomedica S.R.L.
      • Constanța, Romania, 900591
        • Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
      • Craiova, Romania, 200383
        • Neurocord Medical SRL
      • Craiova, Romania, 200513
        • Cardiomed SRL
      • Galati, Romania, 800291
        • SC Diamed Obesity SRL
      • Iași, Romania, 700503
        • Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
      • Iași, Romania, 700547
        • SC Consultmed SRL
      • Iași, Romania, 700732
        • SC Cardiomed SRL
      • Oradea, Romania, 410469
        • Spitalul Clinic Judetean De Urgenta Bihor
      • Paşcani, Romania, 705200
        • Bella Praxis S.R.L.
      • Piteşti, Romania, 110424
        • Sc Sal Med Srl
      • Satu Mare, Romania, 440055
        • Spital Judetean de Urgenta Satu Mare
      • Timișoara, Romania, 300310
        • Institutul de Boli Cardiovasculare Timișoara
      • Timișoara, Romania, 300254
        • Spitalul Clinic Municipal de Urgenta Timisoara
      • Timișoara, Romania, 300366
        • Echipa Medical.33 S.R.L
      • Târgu Mureş, Romania, 540136
        • Spitalul Clinic Judetean de Urgenta Targu Mures
      • Târgu Mureş, Romania, 540136
        • Emergency Institute For Cardiovascular Diseases And Transplant
    • Targu Mures
      • Târgu Mureş, Targu Mures, Romania, 540143
        • CMI Dr. Cristian Podoleanu
  • Serbia
      • Belgrade, Serbia, 11080
        • Clinical Hospital Center Bezanijska Kosa
      • Belgrade, Serbia, 11080
        • Clinical Hospital Centre Zemun
      • Belgrade, Serbia, 11000
        • Clinical centre of Serbia, Clinic for cardiology
      • Belgrade, Serbia, 11000
        • Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
      • Belgrade, Serbia, 11000
        • Emergency Internal Medicine Clinic
      • Belgrade, Serbia, 11000
        • Institute for Cardiovascular Diseases ''Dedinje''
      • Belgrade, Serbia, 11000
        • General Hospital "Euromedik 2"
      • Kamenitz, Serbia, 21204
        • Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica
      • Kragujevac, Serbia, 34000
        • University Clinical Centre Kragujevac
      • Leskovac, Serbia, 16000
        • Medical center Leskovac
      • Niš, Serbia, 18108
        • University Clinical Centre Nis, Clinic for Cardiology
      • Užice, Serbia, 31000
        • Medical center Uzice
  • Singapore
      • Singapore, Singapore, 308433
        • Tan Tock Seng Hospital
      • Singapore, Singapore, 529889
        • Changi General Hospital
      • Singapore, Singapore, 544886
        • Sengkang General Hospital
      • Singapore, Singapore, 169609
        • National Heart Centre Singapore
      • Singapore, Singapore, 119074
        • National University Hospital Singapore
      • Singapore, Singapore, 768828
        • Khoo Teck Puat Hospital
  • Slovakia
      • Bratislava, Slovakia, 833 48
        • Narodny ustav srdcovych a cievnych chorob, a.s.
      • Bratislava, Slovakia, 84108
        • KARDIO-SANUS, spol. s r.o.
      • Košice, Slovakia, 040 22
        • CARDIO D&R, s.r.o.
      • Malacky, Slovakia, 901 22
        • Nemocnicna a.s.
      • Martin, Slovakia, 036 01
        • MED-CENTRUM, s.r.o.
      • Nitra, Slovakia, 949 01
        • Intradia s.r.o.
      • Piešťany, Slovakia, 92101
        • BENIMED, s.r.o.
      • Trnava, Slovakia, 917 02
        • Fakultna nemocnica Trnava
      • Žilina, Slovakia, 010 01
        • MEDIVASA, s.r.o., Kardiologicka ambulancia 1, 2
    • Banská Bystrica Region
      • Brezno, Banská Bystrica Region, Slovakia, 977 01
        • Nemocnica S Poliklinikou Brezno N.O.
    • Presov
      • Svidník, Presov, Slovakia, 089 01
        • Interna SK s.r.o.
  • Slovenia
      • Celje, Slovenia, 3000
        • General hospital Celje - cardiology
      • Ljubljana, Slovenia, 1000
        • UKC Ljubljana, Cardiology department
      • Maribor, Slovenia, 2000
        • UKC Maribor - cardiology
  • South Africa
    • Eastern Cape
      • George, Eastern Cape, South Africa, 6529
        • Excellentis Clinical Trial Consultants
    • Free State
      • Bloemfontein, Free State, South Africa, 9301
        • Josha Research
      • Bloemfontein, Free State, South Africa, 9301
        • IATROS International
      • Bloemfontein, Free State, South Africa, 9301
        • Cardiology Research_Bloemfontein
    • Gauteng
      • Benoni, Gauteng, South Africa, 1501
        • East Rand Physicians Clinical Research Division (Pty) Ltd
      • Centurion, Gauteng, South Africa, 0157
        • Johese Clinical Research
      • Johannesburg, Gauteng, South Africa, 2193
        • Wits Clinical Research
      • Johannesburg, Gauteng, South Africa, 2013
        • Wits Bara Clinical Trial Site
      • Johannesburg, Gauteng, South Africa, 2192
        • Dr Garda Cardiology Practice
      • Lenasia, Gauteng, South Africa, 1827
        • Lenasia Clinical Trial Centre
      • Midrand, Gauteng, South Africa, 1685
        • Shop#1 Health Emporium
      • Pretoria, Gauteng, South Africa, 0184
        • Synexus Watermeyer Clinical Research Centre
      • Pretoria, Gauteng, South Africa, 0157
        • Raslouw Private Hospital
      • Pretoria, Gauteng, South Africa, 0157
        • Dr IO Ebrahim Inc
      • Pretoria, Gauteng, South Africa, 0002
        • Ryexo Clinical Research
      • Pretoria, Gauteng, South Africa, 0083
        • Dr Mpe's Practice
    • KwaZulu-Natal
      • KwaDukuza, KwaZulu-Natal, South Africa, 4449
        • Clinical Research Institute of South Africa
    • KwwaZulu Natal
      • Durban, KwwaZulu Natal, South Africa, 4300
        • KwaPhila Health Solutions
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7530
        • Tiervlei Trial Centre
      • Cape Town, Western Cape, South Africa, 7130
        • Synexus Helderberg Clinical Research Centre
      • Cape Town, Western Cape, South Africa, 7500
        • Dr Corbett
      • Cape Town, Western Cape, South Africa, 7500
        • Tread Research (Pty)Ltd
      • Cape Town, Western Cape, South Africa, 7935
        • Cardiac Clinical Research Unit, University of Cape Town
      • Mossel Bay, Western Cape, South Africa, 6500
        • Dr Hendrik Snyman's Practice
      • Somerset West, Western Cape, South Africa, 7130
        • Synexus Helderberg Clinical Research Centre
      • Worcester, Western Cape, South Africa, 6850
        • Clinical Projects Research
  • South Korea
      • Busan, South Korea, 49241
        • Pusan National University Hospital
      • Cheongju-si, South Korea, 28644
        • Chungbuk National University Hospital
      • Daegu, South Korea, 42601
        • Keimyung University Dongsan Hospital
      • Daejeon, South Korea, 35015
        • Chungnam National University Hospital
      • Gwangju, South Korea, 61469
        • Chonnam National University Hospital
      • Gyeonggi-do, South Korea, 14068
        • Hallym University Sacred Heart Hospital
      • Incheon, South Korea, 21565
        • Gachon University Gil Medical Center
      • Incheon, South Korea, 22332
        • Inha University Hospital
      • Seoul, South Korea, 03080
        • Seoul National University Hospital
      • Seoul, South Korea, 05505
        • Asan Medical Center
      • Seoul, South Korea, 06351
        • Samsung Medical Center
      • Seoul, South Korea, 03722
        • Severance Hospital, Yonsei University Health System
      • Seoul, South Korea, 06591
        • The Catholic University of Korea, Seoul St. Mary's Hospital
      • Seoul, South Korea, 02841
        • Korea University Anam Hospital
      • Seoul, South Korea, 08308
        • Korea University Guro Hospital
      • Wŏnju, South Korea, 26426
        • Wonju Severance Christian Hospital
    • Gyeonggi-do
      • Bucheon-si, Gyeonggi-do, South Korea, 14754
        • Bucheon Sejong Hospital
      • Seongnam-si, Gyeonggi-do, South Korea, 13620
        • Seoul National University Bundang Hospital
    • Gyeongsangnam-do
      • Yangsan, Gyeongsangnam-do, South Korea, 50612
        • Pusan National University Yangsan Hospital
  • Spain
      • A Coruña, Spain, 15006
        • Complejo Hospitalario Universitario A Coruña
      • Barcelona, Spain, 08003
        • Hospital del Mar
      • Barcelona, Spain, 08036
        • Hospital Clinic i Provincial
      • Castilleja de la Cuesta, Spain, 41950
        • Hospital Vithas Sevilla
      • Las Palmas de Gran Canaria, Spain, 35010
        • Hospital Universitario de Gran Canaria Doctor Negrín
      • Las Palmas de Gran Canaria, Spain, 35010
        • Hospital Univ. de Gran Canaria Doctor Negrín
      • Madrid, Spain, 28040
        • Hospital Clínico San Carlos
      • Madrid, Spain, 28046
        • Hospital Universitario La Paz
      • Madrid, Spain, 28034
        • Hospital Ramon y Cajal
      • Madrid, Spain, 28222
        • Hospital Universitario Puerta de Hierro Majadahonda
      • Madrid, Spain, 28003
        • Hospital Univ. La Luz_Cardiología
      • Seville, Spain, 41003
        • Clínica Nuevas Tecnologías en Diabetes y Endocrinología
      • Valencia, Spain, 46014
        • Hospital General de Valencia
      • Valencia, Spain, 46010
        • Fundación para la Investigación del Hospital Clínico de Valencia (INCLIVA)
    • Barcelona
      • Badalona, Barcelona, Spain, 08916
        • Hospital Germans Trias i Pujol
      • L'Hospitalet de Llobregat, Barcelona, Spain, 08907
        • Hospital De Bellvitge
    • Madrid
      • Majadahonda, Madrid, Spain, 28222
        • Hospital Universitario Puerta de Hierro Majadahonda
  • Taiwan
      • Kaohsiung City, Taiwan, 807
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • Kaohsiung City, Taiwan, 833
        • Chang Gung Memorial Hospital - Kaohsiung Branch
      • Taichung, Taiwan, 407
        • Taichung Veterans General Hospital
      • Taichung, Taiwan, 433
        • Kuang Tien General Hospital
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital
      • Taipei, Taiwan, 112
        • Taipei Veterans General Hospital
      • Taoyuan, Taiwan, 333
        • Chang Gung Medical Foundation - Linkou Branch
  • Thailand
      • Bangkok, Thailand, 10330
        • King Chulalongkorn Memorial Hospital
      • Bangkok, Thailand, 10700
        • Siriraj Hospital
      • Bangkok, Thailand, 10210
        • Chulabhorn Hospital
      • Bangkok, Thailand, 10400
        • Ramathibodi Hospital-Cardiovascular metabolic Center
      • Bangkok, Thailand, 10300
        • Cardio-Vajira
      • Bangkok, Thailand, 10300
        • Vajira Hospital - Cardio
      • Bangkok, Thailand, 10210
        • Chulabhorn hospital_Cardiovascular
      • Bangkok, Thailand, 10400
        • Ramathibodi Hospital_Cardiovascular metabolic Center
      • Chiang Mai, Thailand, 50200
        • Maharaj Nakorn Chiang Mai Hospital
      • Chiang Mai, Thailand, 50200
        • Maharaj Nakorn Chiang Mai Hospital_Cardiology
      • Chiang Rai, Thailand, 57000
        • Chiang Rai Prachanukroh Hospital
      • Khon Kaen, Thailand, 40002
        • Srinagarind Hospital
      • Nakhon Ratchasima, Thailand, 30000
        • Maharat Nakhon Ratchasima Hospital
      • Pathum Thani, Thailand, 12120
        • Thammasat Hospital_Cardiology
      • Phitsanulok, Thailand, 65000
        • Buddhachinaraj Hospital_Cardiology
      • Samutsakhon, Thailand, 74120
        • Banphaeo General Hospital
      • Songkhla, Thailand, 90110
        • Songklanagarind Hospital
      • Ubon Ratchathani, Thailand, 34000
        • Sunpasitthiprasong Hospital_Pediatrics Department
    • Changwat Pathum Thani
      • Klong Luang, Pathumthani, Changwat Pathum Thani, Thailand, 12120
        • Thammasat University Hospital
    • Changwat Songkhla
      • Hat Yai, Changwat Songkhla, Thailand, 90110
        • Songklanagarind Hospital
  • Turkey (Türkiye)
      • Afyonkarahisar, Turkey (Türkiye), 03200
        • Afyonkarahisar Health Sciences University
      • Afyonkarahisar, Turkey (Türkiye), 03200
        • Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
      • Ankara, Turkey (Türkiye), 06230
        • Hacettepe Üniversitesi Hastanesi- Kardiyoloji
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Bilkent Şehir Hastanesi-Kardiyoloji
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Sehir Hastanesi Cardiology
      • Antalya, Turkey (Türkiye), 07059
        • Akdeniz University Medical Faculty
      • Antalya, Turkey (Türkiye), 07059
        • Akdeniz Üniversitesi Hastanesi-Kardiyoloji
      • Edirne, Turkey (Türkiye), 22030
        • Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
      • Eskişehir, Turkey (Türkiye), 26040
        • Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
      • Istanbul, Turkey (Türkiye), 34668
        • Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
      • Istanbul, Turkey (Türkiye), 34098
        • İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
      • Istanbul, Turkey (Türkiye), 34303
        • Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH
      • Istanbul, Turkey (Türkiye), 34303
        • Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training Research Hospital_Istanbul
      • Izmir, Turkey (Türkiye), 35100
        • Ege Üniversitesi Hastanesi- Kardiyoloji
      • Izmir, Turkey (Türkiye), 35340
        • Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
      • Kayseri, Turkey (Türkiye), 38039
        • Erciyes Üniversitesi Hastanesi- Kardiyoloji
      • Kocaeli, Turkey (Türkiye), 41380
        • Kocaeli Üniversitesi Hastanesi- Kardiyoloji
      • Mersin, Turkey (Türkiye), 33343
        • Mersin Üniversitesi Hastanesi- Kardiyoloji
  • United Kingdom
      • Aberdeen, United Kingdom, AB25 2ZN
        • Aberdeen Royal Infirmary
      • Bristol, United Kingdom, BS10 5NB
        • Southmead Hospital
      • Craigavon, United Kingdom, BT63 5QQ
        • Craigavon Area Hospital - Cardiovascular Research Unit
      • Dorest, United Kingdom, BH7 7DW
        • Royal Bournemouth Hospital
      • Exeter, United Kingdom, EX2 5DW
        • Royal Devon and Exeter Hospital
      • Exeter, United Kingdom, EX2 5DW
        • Royal Devon University Healthcare NHS Foundation Trust
      • Glasgow, United Kingdom, G31 2ER
        • Glasgow Royal Infirmary
      • High Wycombe, United Kingdom, HP11 2TT
        • Wycombe General Hospital
      • Liverpool, United Kingdom, L9 7AL
        • Aintree University Hospital
      • Manchester, United Kingdom, M13 9WL
        • Manchester Royal Infirmary - Manchester Heart Centre
      • North Shields, United Kingdom, NE29 8NH
        • North Tyneside General Hospital
      • Oldham, United Kingdom, OL1 2JH
        • The Royal Oldham Hospital_Cardiology Outpatients Dept.
      • Oxford, United Kingdom, OX3 9DU
        • John Radcliffe Hospital
      • Stockton-on-Tees, United Kingdom, TS19 8PE
        • University of North Tees Hospital
    • Dorset
      • Bournemouth, Dorset, United Kingdom, BH7 7DW
        • Royal Bournemouth Hospital
    • Essex
      • Basildon, Essex, United Kingdom, SS16 5NL
        • Basildon University Hospital
    • Lanarkshire
      • Airdrie, Lanarkshire, United Kingdom, ML6 0JS
        • University Hospital Monklands - Cardiology Research
    • London
      • Tooting, London, United Kingdom, SW17 0RE
        • St George's Hospital - Cardiology
      • Tooting, London, United Kingdom, SW17 0RE
        • St George's Hospital
    • South Lanarkshire
      • East Kilbride, South Lanarkshire, United Kingdom, G75 8RG
        • University Hospital Hairmyres - Cardiology
    • West Sussex
      • Chichester, West Sussex, United Kingdom, PO19 6SE
        • St. Richards Hospital
      • Chichester, West Sussex, United Kingdom, PO19 6SE
        • St. Richard's Hospital_Cardiology
  • United States
    • Alabama
      • Alexander City, Alabama, United States, 35010
        • Advanced Cardiovascular, LLC
      • Fairhope, Alabama, United States, 36532
        • Eastern Shore Rsrch Inst, LLC
      • Huntsville, Alabama, United States, 35801
        • Heart Center Rsrch_Hunstville
    • Arizona
      • Phoenix, Arizona, United States, 85006
        • Banner University Medical Ctr
    • Arkansas
      • Little Rock, Arkansas, United States, 72204
        • Cardiology & Medicine Clinic
    • California
      • Alhambra, California, United States, 91801
        • InvivoCure -2
      • Beverly Hills, California, United States, 90211
        • National Heart Institute Cal
      • Covina, California, United States, 91723
        • Valley Clinical Trials
      • La Jolla, California, United States, 90237
        • Scripps Memorial Hospital La Jolla
      • La Mesa, California, United States, 91942
        • Purushotham & Akther Kotha MD, inc.
      • Loma Linda, California, United States, 92357
        • VA Loma Linda Hlthcr Sys
      • Los Angeles, California, United States, 90073
        • VA Greater Los Angeles Hlthcare System
      • Los Angeles, California, United States, 90073
        • VAGrtrLosAngelesHlthcareSystem
      • Los Angeles, California, United States, 90035
        • Biopharma Clinical Research Services, LLC
      • Northridge, California, United States, 91325
        • Valley Clinical Trials, Inc.
      • Orange, California, United States, 92868
        • UCI Health
      • Palo Alto, California, United States, 94304
        • Stanford Univ School of Med
      • San Diego, California, United States, 92123
        • San Diego Cardiac Center
      • San Dimas, California, United States, 91773
        • North America Research Institute
      • Stockton, California, United States, 95204
        • Manshadi Heart Institute
      • Torrance, California, United States, 90502
        • Lundquist Inst-Biomed Innovtn
      • Van Nuys, California, United States, 91405
        • InvivoCure
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Rocky Mountain Regional VAMC
      • Denver, Colorado, United States, 80012
        • InvivoCure -2
      • Littleton, Colorado, United States, 80120
        • S Denver Cardiology Associates
    • Connecticut
      • Bridgeport, Connecticut, United States, 06610
        • Bridgeport Hospital
      • Stamford, Connecticut, United States, 06905
        • Cardiology Associates of Fairfield County
    • Florida
      • Coral Gables, Florida, United States, 33134
        • Pioneer Clinical Studies-Coral Gables
      • Crystal River, Florida, United States, 34429
        • Nature Coast Clin Rsrch_Crystal River
      • Fort Lauderdale, Florida, United States, 33312
        • Integrative Research Assoc Inc
      • Hialeah, Florida, United States, 33016
        • New Generation of Medical Research
      • Hollywood, Florida, United States, 33021
        • Memorial Region Hosp_Hollywood
      • Jacksonville, Florida, United States, 32258
        • Baptist Health Research Institute
      • Jacksonville, Florida, United States, 32216
        • Jacksonville Ctr for Clin Res
      • Jacksonville, Florida, United States, 32204
        • E Coast Inst for Rsrch LLC_Jacksonville
      • Miami, Florida, United States, 33173
        • Baptist Health South Florida
      • Miami, Florida, United States, 33176
        • Pioneer Clinical Studies-Coral Gables
      • Naples, Florida, United States, 34102
        • NCH Research Institute
      • North Miami Beach, Florida, United States, 33169
        • Amavita Research Services, LLC
      • Ocala, Florida, United States, 34471
        • Ocala Cardiovascular Research
      • Ormond Beach, Florida, United States, 32174
        • Ormond Beach Clinical Research
      • Saint Augustine, Florida, United States, 32086
        • St Johns Ctr Clin Rsch-St. Aug
      • Wellington, Florida, United States, 33449
        • Cardio Partners Clin Res Inst
      • Winter Haven, Florida, United States, 33881
        • Winter Haven Hospital
      • Winter Park, Florida, United States, 32792
        • Guardian Research Org LLC
    • Georgia
      • Atlanta, Georgia, United States, 30310
        • Morehouse School of Medicine
      • Atlanta, Georgia, United States, 30322
        • Emory University School of Medicine_Atlanta
      • Johns Creek, Georgia, United States, 30024
        • NSC Research, Inc
      • Macon, Georgia, United States, 31201
        • GA Arrhythmia Cons & Rsch Inst
    • Hawaii
      • Honolulu, Hawaii, United States, 96817
        • The Queen's Medical Center
    • Idaho
      • Meridian, Idaho, United States, 83642
        • St. Luke's Idaho Cardiology Associates
    • Illinois
      • Arlington Heights, Illinois, United States, 60005
        • Endeavor Health Clinical Operations-NCH
      • Downers Grove, Illinois, United States, 60515
        • Advocate Good Samaritan
      • Hazel Crest, Illinois, United States, 60429
        • Chicago Medical Research LLC
      • Naperville, Illinois, United States, 60540
        • Midwest Cardiovascular Institute
      • Peoria, Illinois, United States, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, United States, 61614
        • OSF HealthCare_Cardiovasc Inst
    • Indiana
      • Elkhart, Indiana, United States, 46514
        • Midwest Cardiovascu Rsrch Foundation
      • Hammond, Indiana, United States, 46324
        • Asha Clinical Rsch-Munster, LLC
      • Indianapolis, Indiana, United States, 46237
        • Franciscan Network-IN Heart PHY
      • Lebanon, Indiana, United States, 46052
        • Witham Health Services
      • Munster, Indiana, United States, 46321
        • Cardiovascular Rsrch of NW_IN
      • Richmond, Indiana, United States, 47374
        • Reid Physician Associates
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • University of Iowa Hospitals and Clinics
    • Kansas
      • Overland Park, Kansas, United States, 66211
        • Midwest Heart & Vasc Spec
    • Kentucky
      • Elizabethtown, Kentucky, United States, 42701
        • Baptist Health Hardin
      • Lexington, Kentucky, United States, 40503
        • The Research Group of Lexington LLC
      • Louisville, Kentucky, United States, 40202
        • University of Louisville
      • Louisville, Kentucky, United States, 40207
        • Baptist Health Louisville
      • Louisville, Kentucky, United States, 40206
        • Robley Rex VA Medical Center
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Cambridge Medical Trials
      • Bogalusa, Louisiana, United States, 70427
        • Louisiana Heart Center
      • Hammond, Louisiana, United States, 70403
        • Heart Clinic of Hammond
      • New Orleans, Louisiana, United States, 70112
        • University Medical Center New Orleans
    • Maryland
      • Baltimore, Maryland, United States, 21229
        • Ascension Saint Agnes Heart Ca
      • Baltimore, Maryland, United States, 21287
        • Johns Hopkins University_Baltimore
      • Lanham, Maryland, United States, 20706
        • Capitol Cardiology Assoc_Lanham
      • Oxon Hill, Maryland, United States, 20745
        • MD Medical Research
    • Massachusetts
      • Haverhill, Massachusetts, United States, 01830
        • Pentucket Medical Associates
    • Michigan
      • Ann Arbor, Michigan, United States, 48109
        • University of Michigan Medicine
      • Detroit, Michigan, United States, 48201
        • Detroit Med Center-Wayne State
      • Detroit, Michigan, United States, 48202
        • Henry Ford Hlth System_Detroit
      • Flint, Michigan, United States, 48532
        • Elite Research Center
      • Grand Rapids, Michigan, United States, 49546
        • Healthy Heart Cardiology
      • Ypsilanti, Michigan, United States, 48197
        • Trinity Health Michigan Heart
    • Minnesota
      • Maplewood, Minnesota, United States, 55109
        • Fairview Health Services
      • Minneapolis, Minnesota, United States, 55417
        • Minneapolis VA Health Care Sys
    • Mississippi
      • Diamondhead, Mississippi, United States, 39525
        • Hawthorne Health
      • Tupelo, Mississippi, United States, 38801
        • Cardiolg Assoc Rsch LLC_Tupelo
    • Missouri
      • St Louis, Missouri, United States, 63136
        • St Louis Heart & Vascular, P.C.
    • Montana
      • Kalispell, Montana, United States, 59901
        • Logan Health Research
    • Nebraska
      • Omaha, Nebraska, United States, 68198
        • Univ. of Nebraska Medical Center_Omaha
    • Nevada
      • Las Vegas, Nevada, United States, 89128
        • Palm Research Center Inc.
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807-3064
        • Advanced Heart Care LLC
      • Elmer, New Jersey, United States, 08318
        • Heart House_Elmer
      • Linden, New Jersey, United States, 07036
        • NJ Heart
      • Livingston, New Jersey, United States, 07039
        • Barnabas Health
      • Mullica Hill, New Jersey, United States, 08062
        • Inspira Health - Cardiology
      • Newark, New Jersey, United States, 07102
        • Saint Michael's Med Ctr NJ
      • Ridgewood, New Jersey, United States, 07450
        • The Valley Hosptial - Ridgewood
      • Ridgewood, New Jersey, United States, 07450
        • The Valley Hosptial
    • New York
      • Albany, New York, United States, 12211
        • Capital Cardiology Associates_Albany
      • Buffalo, New York, United States, 14215
        • University at Buffalo_Erie County Med Ctr
      • Kew Gardens, New York, United States, 11415
        • Marian David, MD, PC
      • New York, New York, United States, 10021
        • NY Presbyt Hosp-W Cornell Med
      • New York, New York, United States, 10019
        • Mount Sinai Hosp at NYC
      • New York, New York, United States, 10029
        • Mount Sinai Hosp at NYC
      • New York, New York, United States, 10035
        • Harlem Cardiology_Madison ave
      • Rosedale, New York, United States, 11422
        • Laurelton Heart Specialist PC
      • Saratoga Springs, New York, United States, 12866
        • Saratoga Clinical Research
      • Stony Brook, New York, United States, 11794
        • Stony Brook University Hospital
      • The Bronx, New York, United States, 10455
        • Chear Center LLC
    • North Carolina
      • Chapel Hill, North Carolina, United States, 27599
        • UNC Cardiology Outpatient Ctr
      • Concord, North Carolina, United States, 28025
        • Hawthorne Health NC
      • Durham, North Carolina, United States, 27710
        • Duke University
      • Greensboro, North Carolina, United States, 27405
        • Medication Mgmnt, LLC_Grnsboro
      • Lumberton, North Carolina, United States, 28358
        • Duke University/Southeastern
      • Morehead City, North Carolina, United States, 28557
        • Carteret Medical Group
      • Raleigh, North Carolina, United States, 27607
        • UNC Rex Healthcare
    • Ohio
      • Canton, Ohio, United States, 44710
        • Aultman Hospital
      • Marion, Ohio, United States, 43302
        • Rama Research LLC
      • Marion, Ohio, United States, 43302
        • K&R Research Llc
    • Oklahoma
      • Oklahoma City, Oklahoma, United States, 73135
        • South Oklahoma Heart Research, LLC
    • Pennsylvania
      • Camp Hill, Pennsylvania, United States, 17011
        • Capital Area Research LLC
      • Camp Hill, Pennsylvania, United States, 17011
        • Penn State Hlth Holy Spirit Med Ctr
      • Danville, Pennsylvania, United States, 17822
        • Geisinger Medical Center
      • Hershey, Pennsylvania, United States, 17033
        • Penn State Hershey Medical Center
      • Lancaster, Pennsylvania, United States, 17603
        • Heart Grp_ Lancaster Gen Hlth
      • Philadelphia, Pennsylvania, United States, 19114
        • Thomas Jefferson University_Philadelphia
      • Pittsburgh, Pennsylvania, United States, 15212
        • Allegheny Health Network
      • Wyomissing, Pennsylvania, United States, 19610
        • Penn State Health-Berks Cardiology
    • South Carolina
      • Columbia, South Carolina, United States, 29203
        • Prisma Health-Midlands
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Monument Health Clinical Rsrch
      • Sioux Falls, South Dakota, United States, 57117
        • Sanford Health_Sioux Falls
    • Tennessee
      • Jackson, Tennessee, United States, 38305
        • The Jackson Clinic, PA
      • Jackson, Tennessee, United States, 38301
        • Apex Research Foundation, LLC
      • Knoxville, Tennessee, United States, 37934
        • Tennova HC Turkey Creek MC
    • Texas
      • Allen, Texas, United States, 75013
        • Heart MD_Allen TX
      • Amarillo, Texas, United States, 79106
        • PharmaTex Research, LLC
      • Austin, Texas, United States, 78756
        • Austin Heart
      • Dallas, Texas, United States, 75390
        • UTD SW Medical Center-Dallas
      • Duncanville, Texas, United States, 75137
        • Dallas Heart and Vascular
      • El Paso, Texas, United States, 79905
        • David Turbay, MD, PLLC
      • Houston, Texas, United States, 77030
        • Houston Methodist Hospital
      • Houston, Texas, United States, 77030-2703
        • Houston Methodist Hospital
      • Houston, Texas, United States, 77030
        • Texas Heart Inst Medical Ctr
      • Houston, Texas, United States, 77070
        • Card Specialists of Willowbrook
      • Houston, Texas, United States, 77025
        • Biopharma Informatic_Houston
      • Houston, Texas, United States, 77030
        • UT Physicians - Houston Medical Center
      • McKinney, Texas, United States, 75071
        • Texas Institute of Cardiology PA
      • San Antonio, Texas, United States, 78212
        • Clinical Advancement Center
      • San Antonio, Texas, United States, 78229
        • Audie L. Murphy VA Hospital
      • Sherman, Texas, United States, 75092
        • Sherman Clinical Research
    • Vermont
      • Burlington, Vermont, United States, 05401
        • University of Vermont Medical Center
      • Burlington, Vermont, United States, 05401
        • University of Vermont Med Ctr
    • Virginia
      • Charlottesville, Virginia, United States, 22908
        • University of Virginia
      • Chesterfield, Virginia, United States, 23832
        • James River Cardiology
      • Falls Church, Virginia, United States, 22042
        • Virginia Heart
      • Manassas, Virginia, United States, 20109
        • Carient Heart and Vascular
      • Norfolk, Virginia, United States, 23507
        • Sentara Health Research Center
      • Norfolk, Virginia, United States, 23504
        • York Clinical Research LLC
      • Richmond, Virginia, United States, 23298
        • Virginia Commonwealth University
      • Roanoke, Virginia, United States, 24014
        • Roanoke Heart Institute
      • Salem, Virginia, United States, 24153-6404
        • VA Medical Center_Salem
      • Winchester, Virginia, United States, 22601-3834
        • Selma Medical Associates
      • Winchester, Virginia, United States, 22601
        • Valley Health Link
    • Washington
      • Seattle, Washington, United States, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, United States, 98122-5789
        • Swedish Medical Center_Seattle
      • Spokane, Washington, United States, 99204
        • Providence Med Research Ctr
    • West Virginia
      • Morgantown, West Virginia, United States, 26506
        • WVU Heart & Vascular Institute
    • Wisconsin
      • Madison, Wisconsin, United States, 53705
        • William S Middleton Mem VA Hosp
      • Milwaukee, Wisconsin, United States, 53215
        • Aurora St. Luke's Medi Ctr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Serum high-sensitivity C-reactive protein (hs-CRP) greater than equal to 2 milligrams per liter (mg/L) at screening (visit 1) Disease specific - cardiovascular

  • At least one of the following:

    1. N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than equal to 300 picograms per milliliter (pg/mL) at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NTproBNP must be greater than equal to 600 pg/mL. Note that the screening electrocardiogram (ECG) must be obtained the same day as sampling for NT-proBNP.
    2. Hospitalisation or urgent/unplanned visit with a primary diagnosis of decompensated heart failure which required intravenous loop diuretic treatment, within the last 9 months prior to screening (visit 1) in combination with NT-proBNP greater than equal to 200 pg/mL at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NT-proBNP must be greater than equal to 600 pg/mL.
  • Diagnosis of heart failure (New York Heart Association [classification] [NYHA] Class II-IV).
  • Left ventricular ejection fraction (LVEF) greater than 40 percentage (%) documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (e.g., myocardial infarction [MI] or heart failure [HF] hospitalisation).
  • Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
  • Left atrial (LA) volume index greater than 34 milliliter per meter square (mL/m^2).
  • LA diameter greater than equal to 3.8 centimeter (cm).
  • LA length greater than equal to 5.0 cm.
  • LA area greater than equal to 20 cm square.
  • LA volume greater than equal to 55 milliters (mL).
  • Intraventricular septal thickness greater than equal to 1.1 cm.
  • Posterior wall thickness greater than equal to 1.1 cm.
  • Left ventricular (LV) mass index greater than equal to 115 grams per meter square (g⁄m^2 ) in men or greater than equal to 95 g⁄m^2 in women.
  • E/e' (mean septal and lateral) greater than equal to 10.
  • e' (mean septal and lateral) less than 9 centimeter per second (cm/s).
  • No heart failure hospitalisations or urgent heart failure visits between screening (visit 1) and randomisation (visit 2).

Exclusion Criteria:

Medical conditions - cardiovascular

  • Myocardial infarction, stroke, unstable angina pectoris, transient ischaemic attack, or heart failure hospitalisation, within 30 days prior to screening (visit 1).
  • Systolic blood pressure greater than equal to 180 millimeters of mercury (mmHg) at screening (visit 1). If the systolic blood pressure is 160-179 mmHg, the patient should be receiving greater than equal to 3 antihypertensive drugs. (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
  • Heart rate above 110 or below 40 beats per minute as evaluated on the electrocardiogram (ECG) performed at screening (visit 1) (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
  • Planned coronary, carotid or peripheral artery revascularisation known during the screening period (visit 1). (Note: Planned coronary angiogram is not exclusionary).
  • Planned cardiac device or atrial flutter/atrial fibrillation ablation procedure known during the screening period (visit 1).
  • Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
  • Heart failure due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, uncorrected more than moderate primary valve disease.
  • Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD.
  • Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism).

Medical conditions - infections/immunosuppression

- Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Participants will receive ziltivekimab placebo s.c. injection once-monthly and added standard of care for up to 4 years.
Drug: Placebo
Ziltivekimab placebo s.c. injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.
Experimental: Ziltivekimab
Participants will receive ziltivekimab subcutaneous (s.c.) injection once-monthly and added standard of care for up to 4 years.
Drug: Ziltivekimab
Ziltivekimab subcutaneous (s.c.) injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to First Occurrence of a Composite Heart Failure Endpoint Consisting of: Cardiovascular (CV) Death, Heart Failure (HF) Hospitalisation or Urgent HF Visit
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of CV Deaths, HF Hospitalisations or Urgent HF Visits (First and Recurrent)
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured as count of event.
From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: CV Death, HF Hospitalisation or Urgent HF Visit, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: All-cause Death, HF Hospitalisation or Urgent HF Visit, Non-fatal MI, Non-fatal stroke
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)
Time to Occurrence of CV Death
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of HF Hospitalisation or Urgent HF Visit
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)
Number of Events of Atrial Fibrillation
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured as count of event.
From randomisation (month 0) to end of study (up to 48 months)
Change in KCCQ Clinical Summary Score
Time Frame: From randomisation (month 0) to 12 months
KCCQ measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as score.
From randomisation (month 0) to 12 months
Improvement of 5 Points or More in KCCQ Clinical Summary Score (Yes/No)
Time Frame: From randomisation (month 0) to 12 months
Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.
From randomisation (month 0) to 12 months
Improvement of 10 Points or More in KCCQ Clinical Summary Score (Yes/No)
Time Frame: From randomisation (month 0) to 12 months
Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.
From randomisation (month 0) to 12 months
Improvement in New York Heart Association (Classification) [NYHA Class] (Yes/No)
Time Frame: From randomisation (month 0) to 12 months

NEW YORK HEART ASSOCIATION CLASSIFICATION (NYHA) Class I: Participant with cardiac disease but without resulting limitations of physical activity.

Class II: Participants with cardiac disease resulting in slight limitation of physical activity.

Class III: Participants with cardiac disease resulting in marked limitation of physical activity.

Class IV: Participants with cardiac disease resulting in inability to carry on any physical activity without discomfort.

Measured as count of participant.
From randomisation (month 0) to 12 months
Change in Estimated Glomerular Filtration Rate (eGFR) (Chronic Kidney Disease - Epidemiology Collaboration [CKD-EPI])
Time Frame: From randomisation (month 0) to 12 months
Measured as mL/min/1.73 m^2.
From randomisation (month 0) to 12 months
Annual Rate of Change in eGFR (CKD-EPI) (Total eGFR Slope)
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured as mL/min/1.73 m^2/year.
From randomisation (month 0) to end of study (up to 48 months)
Number of Hospitalisations With Infection as Primary Cause or Death Due to Infection
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured as count of event.
From randomisation (month 0) to end of study (up to 48 months)
Change in High-sensitivity C-reactive Protein (hs-CRP)
Time Frame: From randomisation (month 0) to 12 months
Measured as ratio to baseline.
From randomisation (month 0) to 12 months
Change in N-terminal-pro-brain Natriuretic Peptide (NT-proBNP)
Time Frame: From randomisation (month 0) to 12 months
Measured as ratio to baseline.
From randomisation (month 0) to 12 months
Time to Occurrence of all-cause Death
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Measured in months.
From randomisation (month 0) to end of study (up to 48 months)
Hierarchical Composite of: Time to All-cause Death, Number of HF Hospitalisations or Urgent HF Visits, Time to First HF Hospitalisation or Urgent HF Visit, difference of at least 5 in KCCQ clinical summary score change from baseline to 12 months
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as total wins for each treatment group.
From randomisation (month 0) to end of study (up to 48 months)
Time to First Occurrence of a Composite Chronic Kidney Disease (CKD) Endpoint Consisting of: CV death, Onset of Persistent Greater Than Equal To 40 Percentage Reduction in eGFR (CKD- EPI) compared with baseline; Kidney failure
Time Frame: From randomisation (month 0) to end of study (up to 48 months)
eGFR = estimated glomerular filtration rate; CKD-EPI = chronic kidney disease - epidemiology collaboration. Kidney failure defined as: death from kidney failure, onset of persistent eGFR less than 15 milliliters per minute (mL/min)/1.73 meter square (m^2) (CKD-EPI), initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation). Measured in months.
From randomisation (month 0) to end of study (up to 48 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novo Nordisk A/S

Investigators

  • Study Director: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 8, 2023

Primary Completion (Estimated)

July 2, 2027

Study Completion (Estimated)

July 2, 2027

Study Registration Dates

First Submitted

November 23, 2022

First Submitted That Met QC Criteria

November 23, 2022

First Posted (Actual)

December 5, 2022

Study Record Updates

Last Update Posted (Actual)

July 7, 2026

Last Update Submitted That Met QC Criteria

July 3, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EX6018-4915
  • U1111-1280-0810 (Other Identifier: World Health Organization (WHO))
  • jRCT2031230085 (Registry Identifier: jRCT (Japan))
  • 2022-501939-16-00 (Other Identifier: European Medicines Agency (EMA))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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