A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (OCEANIC-STROKE)

November 10, 2025 updated by: Bayer

A Multicenter, International, Randomized, Placebo Controlled, Double-blind, Parallel Group and Event Driven Phase 3 Study of the Oral FXIa Inhibitor Asundexian (BAY 2433334) for the Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older After an Acute Non-cardioembolic Ischemic Stroke or High-risk TIA

Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had:

an acute stroke due to a blood clot that formed outside the heart (acute non-cardioembolic ischemic stroke), or
TIA/mini-stroke with a high risk of turning into a stroke (high-risk transient ischemic attack), and who are planned to receive standard of care therapy. Acute ischemic strokes or TIA/mini-stroke result from a blocked or reduced blood flow to a part of the brain. They are caused by blood clots that travel to the brain and block the vessels that supply it. If these blood clots form elsewhere than in the heart, the stroke is called non-cardioembolic. People who already had a non-cardioembolic stroke are more likely to have another stroke. This is why they are treated preventively with an antiplatelet therapy, the current standard of care. Antiplatelet medicines prevent platelets, components of blood clotting, from clumping together.

Anticoagulants are another type of medicine that prevents blood clots from forming by interfering with a process known as coagulation (or blood clotting).

The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care without increasing the risk of bleeding.

The main purpose of this study is to learn whether asundexian works better than placebo at reducing ischemic strokes in participants who recently had a non-cardioembolic ischemic stroke or TIA/mini-stroke when given in addition to standard antiplatelet therapy. A placebo is a treatment that looks like a medicine but does not have any medicine in it.

Another aim is to compare the occurrence of major bleeding events during the study between the asundexian and the placebo group. Major bleedings have a serious or even life-threatening impact on a person's health.

Dependent on the treatment group, the participants will either take asundexian or placebo once a day for at least 3 months up to 31 months.

Approximately every 3 months during the treatment period, either a phone call or a visit to the study site is scheduled on an alternating basis. In addition, one visit before and up to two visits after the treatment period are planned.

During the study, the study team will:

Check vital signs such as blood pressure and heart rate
Examine the participants' heart health using an electrocardiogram (ECG)
Take blood samples
Ask the participants questions about how they are feeling and what adverse events they are having.

An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. In addition, the participants will be asked to complete a questionnaire on quality of life at certain time points during the study.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

12327

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, TBC
    - Centro Estudios Médicos e Invest. Clínicas "Dr. N. Quirno"
  - Córdoba, Argentina, X5000JHQ
    - Sanatorio Allende | Departamento de Investigación Clínica
  - Salta, Argentina, A4406CLA
    - San Bernardo Hospital | Neurology Department
- Buenos Aires
  - Adrogué, Buenos Aires, Argentina, B1846
    - Clinica IMA
  - Buenos Aires (Capital Federal), Buenos Aires, Argentina, C1221 ADC
    - Hospital General de Agudos JM Ramos Mejia | Neurologia Vascular - Enfermedades Cerebrovasculares
  - Ciudad Autónoma de Buenos Aire, Buenos Aires, Argentina, C1430BKC
    - Hospital General de Agudos Dr. Ignacio Pirovano | Infectology
  - La Plata, Buenos Aires, Argentina, B1900
    - Hospital Italiano de La Plata | Clinical Research Department
  - Lomas de Zamora, Buenos Aires, Argentina, B1832BQD
    - Policlinico Lomas | Neurology Department
  - Mar del Plata, Buenos Aires, Argentina, B7602CBM
    - Hospital Privado de Comunidad | Clinical Research Department
- Ciudad Auton. de Buenos Aires
  - Buenos Aires, Ciudad Auton. de Buenos Aires, Argentina, C1039AAO
    - Galeno | Sanatorio de la Trinidad Mitre - Neurology Department
  - Buenos Aires, Ciudad Auton. de Buenos Aires, Argentina, C1428 AQK
    - Fleni | Sede Belgrano - Neurology Department
  - Buenos Aires, Ciudad Auton. de Buenos Aires, Argentina, C1437JCP
    - Complejo Medico Policial Churruca Visca | Neurology department
  - Ciudad Autonoma de Buenos Aire, Ciudad Auton. de Buenos Aires, Argentina, C1199ABB
    - Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, S2000GAP
    - Grupo Gamma | Hospital Privado de Rosario, Neurology Department
  - Rosario, Santa Fe Province, Argentina, S2000GAP
    - Sanatorio Parque | Departamento de Neurologia
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - The Canberra Hospital
- New South Wales
  - Blacktown, New South Wales, Australia, 2148
    - Blacktown Hospital
  - Liverpool, New South Wales, Australia, 2170
    - South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department
  - New Lambton, New South Wales, Australia, 2305
    - John Hunter Hospital
  - Newtown, New South Wales, Australia, 2042
    - Royal Prince Alfred Hospital
  - Randwick, New South Wales, Australia, 2031
    - Prince of Wales Hospital NSW
  - St Leonards, New South Wales, Australia, 2065
    - Royal North Shore Hospital
  - Sydney, New South Wales, Australia, 2751
    - Nepean Hospital
  - Westmead, New South Wales, Australia, 2145
    - Westmead Hospital
- Queensland
  - Birtinya, Queensland, Australia, 4575
    - Sunshine Coast University Hospital
  - Brisbane, Queensland, Australia, 4029
    - Royal Brisbane and Women's Hospital
  - Brisbane, Queensland, Australia, 4102
    - Princess Alexandra Hospital Australia
  - Redcliffe, Queensland, Australia, 4020
    - Redcliffe District Hospital
  - Southport, Queensland, Australia, 4215
    - Gold Coast University Hospital
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Elizabeth Vale, South Australia, Australia, 5112
    - Lyell McEwin Hospital
- Tasmania
  - Launceston, Tasmania, Australia, 7250
    - Launceston General Hospital
- Victoria
  - Ballarat, Victoria, Australia, 3350
    - Grampians Health Ballarat
  - Box Hill, Victoria, Australia, 3128
    - Eastern Health Box Hill Hospital
  - Clayton, Victoria, Australia, 3168
    - Monash Medical Centre
  - Melbourne, Victoria, Australia, 3004
    - The Alfred Hospital
  - Parkville, Victoria, Australia, 3050
    - Royal Melbourne Hospital
  - St Albans, Victoria, Australia, 3021
    - Western Health Neuroscience Research Unit
- Western Australia
  - Murdoch, Western Australia, Australia, 6961
    - Fiona Stanley Hospital
  - Nedlands, Western Australia, Australia, 6009
    - Sir Charles Gairdner Hospital
Austria
- - Vienna, Austria, 1020
    - Barmherzige Brueder Wien | Abt. fuer Neurologie
  - Vienna, Austria, 1090
    - AKH Wien | Univ. Klinik fuer Neurologie
  - Vienna, Austria, 1160
    - Klinik Ottakring | Neurologische Abteilung
  - Vienna, Austria, 1210
    - Klinik Floridsdorf | Abt. f. Neurologie
- Lower Austria
  - Mödling, Lower Austria, Austria, 2340
    - Landesklinikum Moedling | Abteilung für Neurologie
  - Sankt Pölten, Lower Austria, Austria, 3100
    - Universitätsklinikum St. Pölten
- Salzburg
  - Schwarzach im Pongau, Salzburg, Austria, 5620
    - Kardinal Schwarzenberg Klinikum
- Styria
  - Graz, Styria, Austria, 8036
    - Universitaetsklinikum Graz | Abteilung für Neurologie
- Tyrol
  - Innsbruck, Tyrol, Austria, 6020
    - Medizinische Universitat Innsbruck
- Upper Austria
  - Linz, Upper Austria, Austria, 4020
    - Kepler Universitaetsklinikum GmbH- Med Campus III - Klinik fuer Neurologie 2
  - Linz, Upper Austria, Austria, 4021
    - Barmherzige Brueder Linz | Neurologie
- Vorarlberg
  - Feldkirch, Vorarlberg, Austria, 6800
    - LKH Feldkirch / Neurologie
Belgium
- - Anderlecht, Belgium, 1070
    - Hôpital Erasme/Erasmus Ziekenhuis - Neurology department
  - Bruges, Belgium, 8000
    - AZ Sint-Jan Brugge | Neurology
  - Brussels, Belgium, 1090
    - UZ Brussel
  - Bruxelles - Brussel, Belgium, 1200
    - CU Saint-Luc/UZ St-Luc
  - Ghent, Belgium, 9000
    - UZ Gent
  - Kortrijk, Belgium, 8500
    - AZ Groeninge Campus Kennedylaan - Neurology department
  - Leuven, Belgium, 3000
    - UZ Leuven - Neurology department
  - Liège, Belgium, 4000
    - CHC MontLégia Neurology Department
  - Ostend, Belgium, 8400
    - Kust, Ommeland en Meetjesland (KOM) Network | AZ Damiaan - Neurology Department
  - Sint-Niklaas, Belgium, 9100
    - Vitaz | Sint-Niklaas Hospital - Cardiology Department
  - Uccle, Belgium, 1180
    - Clinique de l'Europe
- Limburg
  - Hasselt, Limburg, Belgium, 3500
    - Jessa Hospital | Neurology Department
Brazil
- - Rio de Janeiro, Brazil, 22281-100
    - L'Dor - Instituto de Ensino e Pesquisa
  - São Paulo, Brazil, 04551-010
    - Science Valley Research Institute
  - São Paulo, Brazil, TBC
    - Unifesp/Epm
- Ceará
  - Fortaleza, Ceará, Brazil, 60150-160
    - Hospital Geral de Fortaleza
- Espírito Santo
  - Espirito Santo, Espírito Santo, Brazil, 29018-140
    - Hospital Estadual Central Vitoria - Fundação INOVA - ES
- Estado de Bahia
  - Salvador, Estado de Bahia, Brazil, 41.810-011
    - Centro de Pesquisas do Hospital Bahia
- Mato Grosso do Sul
  - Campo Grande, Mato Grosso do Sul, Brazil, 79080 190
    - Hospital Universitário UFMS
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30130-100
    - Hospital da Universidade Federal de Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30441-070
    - Hospital Madre Tereza
- Paraná
  - Curitiba, Paraná, Brazil, TBC
    - Hospital das Clinicas da Universidade Federal do Paraná
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
    - Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center
  - Porto Alegre, Rio Grande do Sul, Brazil, 90035-001
    - Hospital Moinhos de Vento-Centro Clínico
- Santa Catarina
  - Joinville, Santa Catarina, Brazil, 89202-165
    - Clínica Neurológica e Neurocirurgica de Joinville LTDA
- São Paulo
  - Botucatu, São Paulo, Brazil, TBC
    - Hospital das Clínicas de Botucatu - UNESP Botucatu
  - Matão, São Paulo, Brazil, 15990-060
    - Sociedade Matonense de Benemerência
  - São José do Rio Preto, São Paulo, Brazil, 15090
    - Fundação Facu. Reg de Medicina de São José do Rio Preto
  - São Paulo, São Paulo, Brazil, 01409-902
    - Hospital Nove de Julho
Bulgaria
- - Dupnitsa, Bulgaria, 2600
    - Multispecialty Hospital for Active Treatment St. Ivan Rilski - 2003 | Neurological Department
  - Haskovo, Bulgaria, 6300
    - Multiprofile Hospital for Active Treatment Haskovo AD | Department of Nervous Diseases
  - Pazardzhik, Bulgaria, 4400
    - Multiprofile Hospital for Active Treatment Pazardzhik
  - Pleven, Bulgaria, 5800
    - Military Medical Academy | Multiprofile Hospital for Active Treatment Pleven - Neurology Department
  - Pleven, Bulgaria, 5800
    - University Multiprofile Hospital for Active Treatment Dr Georgi Stranski Pleven | Department of Neurology
  - Plovdiv, Bulgaria, 4000
    - Multiprofile Hospital for Active Treatment Saint Panteleimon Hospital | Neurology Department
  - Plovdiv, Bulgaria, 4002
    - University Multiprofile Hospital for Active Treatment Pulmed | Neurology Department
  - Rousse, Bulgaria, 7002
    - University Multispecialty Hospital for Active Treatment 'Kanev' JSC | Department of General and Vascular Neurology
  - Sofia, Bulgaria, 1309
    - Multiprofile Hospital for Active Treatment National Cardiology Hospital | Clinic for Neurological Diseases
  - Sofia, Bulgaria, 1000
    - Military Medical Academy | Multiprofile Hospital for Active Treatment Sofia - Clinic of Neurological Diseases
  - Sofia, Bulgaria, 1202
    - Second Multi-profile Hospital for Active Treatment - Sofia | Clinic of Neurology
  - Sofia, Bulgaria, 1527
    - University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Neurology Department
  - Sofia, Bulgaria, 1797
    - Multiprofile Hospital for Active Treatment Neurology and Psychiatry St. Naum | Intensive Treatment of Nervous System Disorders
  - Sofia, Bulgaria, 1797
    - University Multiprofile Hospital for Active Treatment Sofiamed | Neurology Department
  - Sofia, Bulgaria, 1872
    - University Hospital for Active Treatment St. Anna | Neurology Department
  - Sofia, Bulgaria, 1407
    - Acibadem City Clinic University Multiprofile Hospital For Active Treatment Tokuda - Department of Neurology and Sleep Medicine
  - Sofia, Bulgaria, 1606
    - University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD - Department of Nervous Diseases
  - Varna, Bulgaria, 9010
    - MHAT Sveta Marina EAD
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 2T9
    - University of Calgary | Foothills Medical Centre - Department of Clinical Neurosciences - Stroke Clinical Trials Group
  - Edmonton, Alberta, Canada, T6G 2B7
    - University of Alberta Hospital - Canada
  - Lethbridge, Alberta, Canada, T1J 0N9
    - Center for Neurologic Research
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 1T2
    - Kelowna General Hospital
  - New Westminster, British Columbia, Canada, V3L 3W7
    - Royal Columbian Hospital
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Vancouver General Hospital / Vancouver Stroke Program
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 1B2
    - Winnepeg Health Sciences Centre
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 4K4
    - Queen Elizabeth II Complex
- Ontario
  - Greater Sudbury, Ontario, Canada, P3E 5A2
    - Health Sciences North Research Institute | Sudbury, Canada
  - Hamilton, Ontario, Canada, L8L 2X2
    - Hamilton General Hospital
  - Kingston, Ontario, Canada, K7L 2V7
    - Kingston Health Sciences Centre (KGH Site)
  - London, Ontario, Canada, N5R 6M6
    - London Health Sciences Centre
  - Ottawa, Ontario, Canada, K1Y4E9
    - The Ottawa Hospital | The Ottawa Hospital Research Institute - Neurology - Ottawa Stroke Program
  - Toronto, Ontario, Canada, M4N 3M5
    - Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M5C1R6
    - Unity Health Toronto | St. Michael's Hospital - Stroke Research
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - CIUSSS Saguenay Lac-St-Jean
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital
  - Montreal, Quebec, Canada, H2X 0C1
    - CHUM - Centre hospitalier de l'Université de Montréal
  - Montreal, Quebec, Canada, H3A 2B4
    - McGill University Health Center - Neurology Department
  - Québec, Quebec, Canada, G1J 1Z4
    - CHU de Québec-Hôpital de l'Enfant-Jésus
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - CIUSSS de l'Estrie-CHUS, Hopital Fleurimont
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 0W8
    - University of Saskatchewan, Royal University Hospital
China
- - Beijing, China, 100053
    - Xuanwu Hospital Capital Medical University
  - Beijing, China, 102218
    - Beijing Tsinghua Changgung Hospital
  - Shanghai, China, 200040
    - Huashan Hospital, Fudan University
  - Shanghai, China, 200090
    - Yangpu Hospital, Tongji University
  - Tianjin, China, 300350
    - Tianjin Huanhu Hospital
  - Tianjin, China, 300000
    - Tianjin People's Hospital
- Anhui
  - Xuancheng, Anhui, China, 242000
    - Xuancheng People's Hospital
- Gansu
  - Lanzhou, Gansu, China, 730030
    - Lanzhou University Second Hospital
- Guangdong
  - Foshan, Guangdong, China, 528000
    - Foshan First People's Hospital
  - Guangzhou, Guangdong, China, 510280
    - Zhujiang Hospital of Southern Medical University
  - Guangzhou, Guangdong, China, 510000
    - Guangdong Provincial People's Hospital
  - Guangzhou, Guangdong, China, 510630
    - Guangzhou overseas Chinese hospital
- Guangxi
  - Liuzhou, Guangxi, China, 545006
    - People's Hospital of Liuzhou City
- Hainan
  - Haikou, Hainan, China, 570311
    - Hainan General Hospital
- Hebei
  - Cangzhou, Hebei, China, 61000
    - Cangzhou Central Hospital
  - Hengshui, Hebei, China, 53000
    - Hengshui Harrison International Peace Hospital
  - Shijiazhuang, Hebei, China, 50051
    - The Third Hospital of Hebei Medical University
  - Tangshan, Hebei, China, 63001
    - Tangshan People's Hospital
- Heilongjiang
  - Daqing, Heilongjiang, China, 163316
    - Daqing People's Hospital
  - Daqing, Heilongjiang, China, 163311
    - Daqing Oilfield General Hospital
- Henan
  - Luoyang, Henan, China, 471000
    - 1st Affiliated Hospital of Henan Science and Technology Univ
  - Luoyang, Henan, China, 471002
    - Luoyang Third People's Hospital
  - Xinxiang, Henan, China, 453000
    - Xinxiang Central Hospital
  - Xinxiang, Henan, China, 453003
    - The Third Affiliated Hospital of Xinxiang Medical University
- Hubei
  - Wuhan, Hubei, China, 430014
    - The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...
  - Wuhan, Hubei, China, 430034
    - Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech
- Hunan
  - Changsha, Hunan, China, 410000
    - The Third Xiangya Hospital of Central South University
  - Hengyang, Hunan, China, 421001
    - 1st Affiliated Hospital of Nanhua University
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 14010
    - The First Affiliated Hospital of Baotou Medical College
  - Baotou, Inner Mongolia, China, 14010
    - Baogang Hospital
- Jiangsu
  - Huai'an, Jiangsu, China, 223001
    - The Affiliated Huaian No.1 People's Hospi of NJ Medical Unv.
  - JiangSu, Jiangsu, China, 212001
    - Affiliated Hospital of Jiangsu University
  - Nanjing, Jiangsu, China, 210006
    - Nanjing First Hospital
  - Nanjing, Jiangsu, China, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, Jiangsu, China, 210000
    - The Second Affiliated Hospital of Nanjing Medical University
  - Wuxi, Jiangsu, China, 214023
    - Wuxi People's Hospital
  - Wuxi, Jiangsu, China, 214002
    - Wuxi No.2 People's Hospital
  - Xuzhou, Jiangsu, China, 221009
    - Xuzhou Central Hospital
  - Yangzhou, Jiangsu, China, 225007
    - Affiliated Hospital of Yangzhou University
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - The First Affiliated Hospital of NanChang University
  - Nanchang, Jiangxi, China, 330006
    - Jiangxi Provincial People's Hospital
- Jilin
  - Changchun, Jilin, China, 130061
    - The First Hospital of Jilin University
- Liaoning
  - Jinzhou, Liaoning, China, 121001
    - The First Affiliated Hospital of Jinzhou Medical University
  - Shenyang, Liaoning, China, 110016
    - General Hospital of Northern Theater Command
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - General Hospital of Ningxia Medical University
- Qinghai
  - Xining, Qinghai, China, 810001
    - Qinghai University Affiliated Hospital
- Shaanxi
  - Baoji, Shaanxi, China, 721008
    - Baoji Central Hospital
  - Xi'an, Shaanxi, China, 710068
    - Shaanxi Provincial People's Hospital
  - Xianyang, Shaanxi, China, 716000
    - Yan'an University Xianyang Hospital
- Shandong
  - Jinan, Shandong, China, 250012
    - Qilu Hosp., Shandong Univ.
  - Jining, Shandong, China, 272007
    - Affiliated Hospital of Jining Medical University
  - Jining, Shandong, China, 272001
    - Jining No.1 People's Hospital
  - Liaocheng, Shandong, China, 252000
    - Liaocheng People's Hospital
  - Linyi, Shandong, China, 276003
    - Linyi People's Hospital
  - Taian, Shandong, China, 271099
    - Taian City Central Hospital
- Sichuan
  - Deyang, Sichuan, China, 618000
    - People's Hospital of Deyang City
- Zhejiang
  - Hangzhou, Zhejiang, China, 310016
    - Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine
  - Ningbo, Zhejiang, China, 31510
    - Hwa Mei Hospital, University of Chinese Academy Sciences
  - Taizhou, Zhejiang, China, 317099
    - Taizhou Hospital of Zhejiang Province
Colombia
- - Cali, Colombia, 760032
    - Fundación Valle de Lili
  - Florida Blanca, Colombia, 681004
    - Fundación Oftalmológica de Santander Carlos Ardila Lule
  - Floridablabca, Colombia, 681011
    - Fundacion Cardiovascular de Colombia
  - Medellín, Colombia, 050010
    - Hospital San Vicente Fundación
  - Medellín, Colombia, 050034
    - Clinica Cardio VID
  - Medellín, Colombia, 050030
    - Clínica Medellín
- Antioquia
  - Medellín, Antioquia, Colombia, 050010
    - Hospital Alma Mater de Antioquia
  - Medellín, Antioquia, Colombia, 050015
    - Hospital General de Medellin
  - Medellín, Antioquia, Colombia, 050023
    - Promotora Médica Las Américas S.A.- Clinica Las Americas
  - Rionegro, Antioquia, Colombia, 054040
    - Sociedad Médica Rionegro SOMER S.A.
- Atlántico
  - Baranquilla, Atlántico, Colombia, 080020
    - Clínica de la Costa SAS
  - Soledad, Atlántico, Colombia, TBC
    - Fundación Hospital Universidad del Norte
- Bogota D.C.
  - Bogotá, Bogota D.C., Colombia
    - Hospital Universitario Mayor-Méderi
- Cundinamarca
  - Chía, Cundinamarca, Colombia, 250001
    - Clínica Universidad de La Sabana
- Quindío Department
  - Armenia, Quindío Department, Colombia, 630004
    - Cardiomet Cequin Sas
- Valle del Cauca Department
  - Cali, Valle del Cauca Department, Colombia, 760042
    - Clinica IMBANACO S.A.S
Czechia
- - Brno, Czechia, 602 00
    - Fakultni nemocnice u sv. Anny - I.neurologicka klinika
  - Chomutov, Czechia, 430 12
    - Nemocnice Chomutov, o.z.
  - Fryštát, Czechia, 735 06
    - Karvinska hornicka nemocnice a.s. - Neurologicke oddeleni
  - Jihlava, Czechia, 586 33
    - Nemocnice Jihlava - Neurologicke oddeleni
  - Liberec, Czechia, 460 63
    - Krajska nemocnice Liberec - neurologicke oddeleni
  - Ostrava - Poruba, Czechia, 708 52
    - Fakultni nemocnice Ostrava - Neurologicka klinika
  - Ostrava - Vitkovice, Czechia, 703 00
    - Nemocnice AGEL Ostrava-Vítkovice a. s. - Neurologické oddelení
  - Pardubice, Czechia, 532 03
    - Nemocnice Pardubickeho Kraje, as - Neurologická klinika
  - Prague, Czechia, 100 34
    - Fakultni nemocnice Kralovske Vinohrady - Neurologicka klinika
  - Prague, Czechia, 14059
    - Fakultni Thomayerova Nemocnice - neurology department
  - Prague, Czechia, 16900
    - Ustredni vojenska nemocnice Praha
  - Praha 5-Motol, Czechia, 150 00
    - Nemocnice na Homolce - Neurology Department
  - Zlín, Czechia, 762 75
    - Krajská nemocnice T. Bati - Neurologické oddelení
  - Ústí nad Labem, Czechia, 401 13
    - Krajská Zdravotní, Masarykova nemocnice Ústí nad Labem - Neurologické oddelení
  - České Budějovice, Czechia, 370 01
    - Nemocnice Ceske Budejovice, a.s. - Department of neurology
Denmark
- - Aalborg, Denmark, 9000
    - Aalborg Universitetshospital - Neurologisk afdeling
  - Aarhus N, Denmark, 8200
    - Aarhus Universitetshospital, Neurologisk Afdeling
  - Glostrup Municipality, Denmark, 2600
    - Rigshospitalet Glostrup - Hjerne og Nervesygdomme
  - Herlev, Denmark, 2730
    - Herlev Hospital - Hjerne og Nervesygdomme
  - Herning, Denmark, 7400
    - Regionshospitalet Gødstrup - Neurologi
  - Kolding, Denmark, 6000
    - Lillebælt Sygehus Kolding - Hjerne og Nervesygdomme
  - København NV, Denmark, 2400
    - Bispebjerg Hospital - Neurologisk afdeling
  - Odense C, Denmark, 5000
    - Odense Universitetshospital - Neurologisk afdeling
Finland
- - Helsinki, Finland, 29
    - HUS, Meilahden sairaala
  - Joensuu, Finland, 80210
    - Pohjois-Karjalan sairaanhoitopiiri
  - Kuopio, Finland, 70210
    - Kuopion Yliopistollinen Sairaala
  - Tampere, Finland, 33520
    - Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS)
  - Turku, Finland, 20520
    - Turun yliopistollinen keskussairaala
France
- - Besançon, France, 25000
    - CHRU Besancon - Hopital Jean Minjoz - Service neurologie
  - Bordeaux, France, 33000
    - Hopital Pellegrin _ Soins Intensifs Unite Neurovasculaire
  - Boulogne-sur-Mer, France, 62321
    - Centre Hospitalier Boulogne sur Mer - Neurologie
  - Brest, France, 29609
    - CHU de Brest - Hôpital La Cavale Blanche
  - Corbeil-Essonnes, France, 91100
    - CH Sud Francilien, Neurologie
  - Dijon, France, 21079
    - CHU Dijon - Hopital Francois Mitterand - Service neurologie generale vasculaire et degenerative
  - Garches, France, 92380
    - Hopital Raymond-Poincare _ Service de Neurologie
  - Le Kremlin-Bicêtre, France, 94275
    - Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Bicetre
  - Le Mans, France, 72037 Cedex 09
    - Centre Hospitalier - Le Mans _ Service de Neurologie
  - Lille, France, 59037
    - Hopital Salengro _ Service de Neurologie et Pathologie Neurovasculaire
  - Lomme, France, 59160
    - GHICL - Hopital Saint-Philibert
  - Nancy, France, 54000
    - CHRU Nancy - Hopital central - Service de neurologie
  - Nice, France, 06000
    - CHU de Nice - Hopital Pasteur - Unite Neuro Vasculaire
  - Nîmes, France, 30900
    - Hopital Caremeau _ Service de Neurologie
  - Paris, France, 75014
    - Centre Hospitalier Sainte Anne
  - Paris, France, 75475
    - AP-HP - Hopital Lariboisiere
  - Paris, France, 75013
    - Hopital de la Pitie-Salpetriere _ Service des Urgences Cerebro-Vasculaires
  - Paris, France, 75018
    - APHP Hopital Bichat Claude Bernard - Service de Neurologie
  - Paris, France, 75019
    - APHP - Hopital Fondation Adolphe De Rothschild - Service de Neurologie
  - Reims, France, 51092
    - CHU de Reims - Hopital de la Maison Blanche - Service de Neurologie
  - Rennes, France, 35033
    - CHU Rennes - Hopital Pontchaillou - Service de neurologie
  - Saint-Herblain, France, 44800
    - CHU de Nantes - Hopital Laennec - Unite neurovasculaire
  - Suresnes, France, 92151
    - Hopital Foch - Service de Neurologie
  - Toulon, France, 83800
    - Hopital instruction des Armees Sainte Anne
  - Toulouse, France, 31059
    - CHU Toulouse - Hopital Pierre Paul Riquet PURPAN
  - Tours, France, 37044
    - CHRU de Tours - Hôpital Bretonneau - Service de neurologie
- Auvergne-Rhône-Alpes
  - Bron, Auvergne-Rhône-Alpes, France, 69477
    - HCL - Hopital Louis Pradel - Service de Neurologie
- Bouches-du-Rhône
  - Marseille, Bouches-du-Rhône, France, 13005
    - AP-HM - Hopital de la Timone - Service de Neurologie
- Grand Est
  - Strasbourg, Grand Est, France, 67098
    - CHU Strasbourg - Hopital Hautepierre - Service Neurologie
Germany
- - Berlin, Germany, 12351
    - Vivantes Klinikum Neukölln / Neurologie mit Stroke Unit
  - Hamburg, Germany, 22307
    - Asklepios Klinik Barmbek/ Neurologie
  - Hamburg, Germany, 22043
    - Asklepios Klinik Wandsbek/Neurologie
  - Hamburg, Germany, 22763
    - Asklepios Klinik Altona Hamburg / Neurologie
- Baden-Wurttemberg
  - Freiburg im Breisgau, Baden-Wurttemberg, Germany, 79106
    - Universitätsklinikum Freiburg / Neurologie
  - Heidelberg, Baden-Wurttemberg, Germany, 69120
    - Universitaetsklinikum Heidelberg / Neurologie
  - Ulm, Baden-Wurttemberg, Germany, 89081
    - Universitätsklinikum Ulm/Neurologische Klinik
- Bavaria
  - Bad Neustadt an der Saale, Bavaria, Germany, 97616
    - Rhön-Klinikum Campus Bad Neustadt/Neurologie
  - Erlangen, Bavaria, Germany, 91054
    - Universitätsklinikum Erlangen/Neurologie
- Hesse
  - Frankfurt am Main, Hesse, Germany, 60590
    - Universitätsklinikum Frankfurt / Neurologie
  - Giessen, Hesse, Germany, 35385
    - Universität Gießen-Marburg, Standort Gießen/Neurologie
- Lower Saxony
  - Göttingen, Lower Saxony, Germany, 37075
    - Universitätsmedizin Göttingen/ Neurologie
  - Hanover, Lower Saxony, Germany, 30625
    - Medizinische Hochschule Hannover/Neurologie
- Mecklenburg-Vorpommern
  - Greifswald, Mecklenburg-Vorpommern, Germany, 17475
    - Universitätsmedizin Greifswald/Neurologie
- North Rhine-Westphalia
  - Aachen, North Rhine-Westphalia, Germany, 52074
    - UniKlinikum Aachen/Neurologie
  - Bonn, North Rhine-Westphalia, Germany, 53127
    - Uniklinik Bonn / Neurologie
  - Düsseldorf, North Rhine-Westphalia, Germany, 40225
    - Universitätsklinikum Düsseldorf / Neurologie
  - Düsseldorf, North Rhine-Westphalia, Germany, 40479
    - Marien Hospital Düsseldorf / Neurologie
  - Essen, North Rhine-Westphalia, Germany, 45131
    - Alfried Krupp Krankenhaus Rüttenscheid /Neurologie
  - Troisdorf, North Rhine-Westphalia, Germany, 53844
    - GFO KlinikTroisdorf/Neurologie
- Rhineland-Palatinate
  - Mainz, Rhineland-Palatinate, Germany, 55131
    - Johannes Gutenberg-Universität Mainz - Neurologie
- Saxony
  - Dresden, Saxony, Germany, 1067
    - Städtisches Klinikum Dresden / Neurologie
  - Dresden, Saxony, Germany, 1307
    - Universitätsklinikum Dresden/Neurologie
  - Leipzig, Saxony, Germany, 4103
    - Universitätsklinik Leipzig /Neurologie
- Saxony-Anhalt
  - Halle, Saxony-Anhalt, Germany, 6120
    - Universitätsklinikum Halle (Saale)/Neurologie
- Thuringia
  - Altenburg, Thuringia, Germany, 4600
    - Klinikum Altenburger Land / Studienzentrum Neurologie
  - Bad Langensalza, Thuringia, Germany, 99947
    - SRH Wald-Klinikum Gera gGmbH
  - Jena, Thuringia, Germany, 7747
    - Uniklinik Jena/ Neurologie
Greece
- - Alexandroupoli, Greece, 68100
    - University General Hospital Of Alexandroupoli- Department of Neurology
  - Ampelokipoi Athens, Greece, 11526
    - General Hospital Of Athens Korgialenio Benakio H.R.C.- Department of Neurology
  - Athens, Greece, 10676
    - Evaggelismos Hospital-Department of Neurology
  - Athens, Greece, 11521
    - Naval Hospital of Athens-Department of Neurology
  - Athens, Greece, 11525
    - 401 General Military Hospital Of Athens- Department of Neurology
  - Athens, Greece, 11527
    - General Hospital Of Athens G Gennimatas- Department of Neurology
  - Athens, Greece, 11528
    - Eginitio Hospital-1st Department of Neurology
  - Athens, Greece, 12462
    - University General Hospital Attikon-2nd Department of Neurology
  - Efkarpia, Greece, 56429
    - General Hospital Of Thessaloniki Papageorgiou-3rd Department of Internal Medicine
  - Heraklion, Greece, 711 10
    - University General Hospital of Heraklion - Department of Neurology
  - Ioannina, Greece, 45500
    - University General Hospital Of Ioannina-Department of Neurology
  - Larissa, Greece, 41110
    - University General Hospital of Larissa-Department of Neurology
  - Piraeus, Greece, 18547
    - Metropolitan Hospital- Stroke Unit
  - Pátrai, Greece, 26504
    - General University Hospital Of Patras-Department of Neurology
  - Thessaloniki, Greece, 546 36
    - University General Hospital Of Thessaloniki Ahepa-2nd Department of Neurology
  - Thessaloniki, Greece, 54636
    - University General Hospital Of Thessaloniki Ahepa-1st Department of Neurology
  - Thessaloniki, Greece, 57010
    - Geniko Nosokomeio Thessalonikis George Papanikolaou-3rd Department of Neurology
Hungary
- - Baja, Hungary, 6500
    - Bajai Szent Rokus Korhaz
  - Budapest, Hungary, 1134
    - Észak-Pesti Centrumkórház-Honvédkórház
  - Budapest, Hungary, 1204
    - Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Budapest, Hungary, 1106
    - Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet
  - Budapest, Hungary, 1083
    - Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Neurologiai Klinika
  - Budapest, Hungary, 1145
    - Semmelweis Egyetem Idegsebeszeti es Neurointervencios Klinika
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem Klinikai Kozpont Neurologiai Klinika
  - Győr, Hungary, 9024
    - Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
  - Kistarcsa, Hungary, 2143
    - Kistarcsai Flor Ferenc Korhaz
  - Kisvárda, Hungary, 4600
    - Szent Damján Görögkatolikus Kórház - Neurologiai es Stroke Osztaly
  - Nagykanizsa, Hungary, 8800
    - Nagykanizsai Kanizsai Dorottya Korhaz
  - Nyíregyháza, Hungary, 4400
    - Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz
  - Pécs, Hungary, 7624
    - Pécsi Tudományegyetem Klinikai Központ
  - Sopron, Hungary, 9400
    - Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet
  - Szeged, Hungary, 6725
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar Szent-Gyorgyi Albert Klinikai Kozpont Neurologiai Klinika
  - Zalaegerszeg, Hungary, 8900
    - Zala Varmegyei Szent Rafael Korhaz
India
- - Coimbatore, India, 641018
    - K.G. Hospital
  - Gurgaon, India, 122001
    - Artemis Hospitals
  - Karamsad, India, 388325
    - Shree Krishna Hospital
  - New Delhi, India, 110 029
    - All India Institute of Medical Sciences (AIIMS) - New Delhi
  - Thiruvananthapuram, India, 695011
    - Government Medical College - Thiruvanathapuram
  - Vellore, India, 632004
    - Christian Medical College & Hospital (CMCH) - Vellore
- Andhra Pradesh
  - Guntur, Andhra Pradesh, India, 522001
    - Lalitha Super Specialities Hospital
  - Guntur, Andhra Pradesh, India, 522004
    - Government General Hospital, Guntur
- Gujarat
  - Ahmedabad, Gujarat, India, 380054
    - Zydus Hospital
- Kerala
  - Kozhikode, Kerala, India, 673016
    - Aster MIMS Hospital, Kozhikode
  - Thiruvananthapuram, Kerala, India, 695011
    - Sree Chitra Tirunal Institute for Medical Sciences and Technology
- Telangana
  - Hyderabad, Telangana, India, 500082
    - Yashoda Hospital
Israel
- - Ashdod, Israel, 7747629
    - Assuta Ashdod Public Hospital (R.A)
  - Ashkelon, Israel, 7830604
    - Barzilai Medical Center | Neurology Department
  - Beersheba, Israel, 8410101
    - Clalit Health | Soroka Medical Center - Internal Medicine Department
  - Hadera, Israel, 3810101
    - Hillel Yaffe Medical Center
  - Haifa, Israel, 3109601
    - Rambam Health Corporation
  - Haifa, Israel, 3436212
    - Lady Davis Carmel Medical Center
  - Holon, Israel, 5822012
    - Edith Wolfson Medical Center | Internal Medicine Department
  - Jerusalem, Israel, 9112001
    - Hadassah Hebrew University Hospital Ein Kerem
  - Jerusalem, Israel, 9372212
    - Shaare Zedek Medical Center
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Petah Tikva, Israel, 4941492
    - Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department
  - Ramat Gan, Israel, 5262000
    - Chaim Sheba Medical Center
  - Safed, Israel, 1311001
    - Health Corporation of the Ziv Medical Center (R.A.)
  - Tel Aviv, Israel, 6423906
    - Tel-Aviv Sourasky Medical Center
  - Ẕerifin, Israel, 7030000
    - Shamir Medical Center (Assaf Harofeh)
Italy
- - Torino, Italy, 10154
    - Azienda Sanitaria Locale Citta Di Torino - Ospedale San Giovanni Bosco - Neurologia 2
- Abruzzo
  - Avezzano, Abruzzo, Italy, 67051
    - Azienda Sanitaria Locale Avezzano Sulmona L'Aquila - Ospedale SS. Filippo e Nicola - Neurologia
- Ancona
  - Torrette, Ancona, Italy, 60126
    - Azienda Ospedaliero Universitaria Delle Marche - Clinica Neurologica
- Apulia
  - Lecce, Apulia, Italy, 73100
    - ASL Della Provincia Di Lecce_Ospedale Vito Fazzi - Neurologia
- Campania
  - Napoli, Campania, Italy, 80131
    - Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli - Neurologia
  - Salerno, Campania, Italy, 84131
    - A.O.U San Giovanni Di Dio E Ruggi d'Aragona - Neurologia e Stroke Unit
- Emilia-Romagna
  - Bologna, Emilia-Romagna, Italy, 40133
    - Azienda Unita Sanitaria Locale Di Bologna_ Ospedale Maggiore Pizzardi - Neurologia
  - Cesena, Emilia-Romagna, Italy, 47521
    - AUSL della Romagna_Ospedale Bufalini - Neurologia
  - Parma, Emilia-Romagna, Italy, 43126
    - Azienda Ospedaliero Universitaria Parma - SC Percorso Stroke Care
- Friuli Venezia Giulia
  - Udine, Friuli Venezia Giulia, Italy, 33100
    - ASU Friuli Centrale_Ospedale "Santa Maria della Misericordia" - Neuroscienze
- Lazio
  - Rome, Lazio, Italy, 00133
    - Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOSD Stroke Unit
  - Rome, Lazio, Italy, 00168
    - Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Neurologia
- Liguria
  - Pietra Ligure, Liguria, Italy, 17027
    - Azienda Sociosanitaria Ligure 2_Ospedale Santa Corona - Neurologia Ponente
- Lombardy
  - Bergamo, Lombardy, Italy, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Neurologia
  - Milan, Lombardy, Italy, 20132
    - Ospedale San Raffaele s.r.l. - Neurologia
- Sicily
  - Messina, Sicily, Italy, 98124
    - Azienda Ospedaliera Universitaria Gaetano Martino Messina - Stroke Unit
  - Palermo, Sicily, Italy, 90146
    - Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Neurologia e Stroke Unit
- Tuscany
  - Florence, Tuscany, Italy, 50134
    - Careggi University Hospital - Stroke Unit
  - Siena, Tuscany, Italy, 53100
    - Azienda Ospedaliera Universitaria Senese - Stroke unit
- Umbria
  - Perugia, Umbria, Italy, 06129
    - A.O. di Perugia_Hospital Santa Maria della Misericordia - S.S. Stroke Unit
- Veneto
  - Negrar, Veneto, Italy, 37024
    - IRCCS Ospedale Sacro Cuore Don Calabria - Neurologia
  - Verona, Veneto, Italy, 37126
    - Azienda Ospedaliera Universitaria Integrata Verona_Borgo Trento - Neurologia A
Japan
- - Fukuoka, Japan, 810-0001
    - Saiseikai Fukuoka General Hospital
  - Fukuoka, Japan, 815-8588
    - Kyushu Central Hospital
  - Fukuoka, Japan, 811-1313
    - Fukuoka Neurosurgical Hospital
  - Fukuoka, Japan, 811-0213
    - Social Medical Corporation The Chiyukai Foundation Fukuoka Wajiro Hospital
  - Hiroshima, Japan, 731-0293
    - Hiroshima City North Medical Center Asa Citizens Hospital
  - Kochi, Japan, 780-8562
    - Japanese Red Cross Kochi Hospital
  - Kumamoto, Japan, 862-8505
    - Kumamoto City Hospital
  - Kyoto, Japan, 601-1495
    - Ijinkai Takeda General Hospital
  - Kyoto, Japan, 600-8558
    - Koseikai Takeda Hospital
  - Nagano, Japan, 381-8551
    - Nagano Municipal Hospital
  - Okayama, Japan, 7008557
    - CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial Centre
  - Osaka, Japan, 540-0006
    - National Hospital Organization Osaka National Hospital
  - Osaka, Japan, 558-8558
    - Osaka General Medical Center
  - Shizuoka, Japan, 420-8630
    - Shizuoka City Shizuoka Hospital
  - Shizuoka, Japan, 424-8636
    - Shizuoka City Shimizu Hospital
  - Wakayama, Japan, 640-8558
    - Wakayama Medical University Hospital
- Aichi-ken
  - Nagoya, Aichi-ken, Japan, 454-8502
    - Nagoya Ekisaikai Hospital
  - Nagoya, Aichi-ken, Japan, 455-8530
    - Chubu Rosai Hospital
  - Seto, Aichi-ken, Japan, 489-8642
    - Tosei General Hospital
  - Toyoake, Aichi-ken, Japan, 470-1192
    - Fujita Health University Hospital
  - Toyohashi, Aichi-ken, Japan, 440-8510
    - National Hospital Organization Toyohashi Medical Center
- Chiba
  - Kisarazu, Chiba, Japan, 292-8535
    - Kimitsu Chuo Hospital
  - Sakura, Chiba, Japan, 285-8741
    - Toho University Sakura Medical Center
- Fukuoka
  - Fukuoka, Fukuoka, Japan, 810-8563
    - National Hospital Organization Kyushu Medical Center
  - Kitakyushu, Fukuoka, Japan, 802-8555
    - Kokura Memorial Hospital
  - Kitakyushu, Fukuoka, Japan, 805-8508
    - Steel Memorial Yawata Hospital
- Fukushima
  - Kōriyama, Fukushima, Japan, 963-8052
    - Southern TOHOKU Medical Clinic
- Gifu
  - Takayama, Gifu, Japan, 506-8550
    - Japanese Red Cross Takayama Hospital
- Gunma
  - Maebashi, Gunma, Japan, 371-0811
    - Maebashi Red Cross Hospital
- Hiroshima
  - Aki-gun, Hiroshima, Japan, 735-8585
    - Mazda Motor Corporation Mazda Hospital
  - Hatsukaichi, Hiroshima, Japan, 738-8503
    - Hiroshima General Hospital
  - Higashihiroshima, Hiroshima, Japan, 739-0041
    - Higashihiroshima Medical Center
- Hokkaido
  - Asahikawa, Hokkaido, Japan, 070-8530
    - Japanese Red Cross Asahikawa Hospital
  - Hakodate, Hokkaido, Japan, 041-0802
    - Hakodate Shintoshi Hospital
  - Sapporo, Hokkaido, Japan, 006-8555
    - Teine Keijinkai Hospital
- Hyōgo
  - Akashi, Hyōgo, Japan, 674-0064
    - Ohnishi Neurological Center
  - Himeji, Hyōgo, Japan, 670-8560
    - Hyogo Prefectural HarimaHimeji General Medical Center
  - Kobe, Hyōgo, Japan, 652-0803
    - Eishokai Yoshida Hospital
- Ibaraki
  - Toride, Ibaraki, Japan, 302-0022
    - Ja Toride Medical Center
  - Tsuchiura, Ibaraki, Japan, 300-0028
    - Tsuchiura Kyodo General Hospital
- Kagawa-ken
  - Marugame, Kagawa-ken, Japan, 763-8502
    - Japan Organization of Occupational Health and Safety Kagawa Rosai Hospital
  - Takamatsu, Kagawa-ken, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
  - Takamatsu, Kagawa-ken, Japan, 760-0017
    - Takamatsu Red Cross Hospital
- Kanagawa
  - Kawasaki-shi, Kanagawa, Japan, 211-8533
    - Nippon Medical School Musashikosugi Hospital
  - Odawara, Kanagawa, Japan, 250-0001
    - Seisho Hospital
  - Yokohama, Kanagawa, Japan, 245-8575
    - National Hospital Organization Yokohama Medical Center
  - Yokohama, Kanagawa, Japan, 234-0054
    - Saiseikai Yokohamashi Nanbu Hospital
- Kyoto
  - Uji, Kyoto, Japan, 611-0041
    - Uji-Tokushukai Medical Center
- Miyagi
  - Sendai, Miyagi, Japan, 982-8523
    - Kohnan Hospital
- Nagano
  - Nakano, Nagano, Japan, 383-8505
    - Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General Hospital
  - Suwa, Nagano, Japan, 392-8510
    - Japanese Red Cross Society Suwa Hospital
- Oita Prefecture
  - Beppu, Oita Prefecture, Japan, 874-0011
    - National Hospital Organization Beppu Medical Center
- Okayama-ken
  - Okayama, Okayama-ken, Japan, 700-8607
    - Japanese Red Cross Okayama Hospital
- Osaka
  - Daitō, Osaka, Japan, 574-0074
    - Nozaki Tokushukai Hospital
  - Osaka, Osaka, Japan
    - Kotobuki Social Medical Corporation Tominaga Hospital
  - Suita, Osaka, Japan, 565-0862
    - Osaka Saiseikai Senri Hospital
- Saga-ken
  - Ureshino, Saga-ken, Japan, 843-0393
    - National Hospital Organization Ureshino Medical Center
- Shizuoka
  - Hamamatsu, Shizuoka, Japan, 430-8525
    - Hamamatsu Rosai Hospital
- Tokyo
  - Meguro-ku, Tokyo, Japan, 152-8902
    - National Hospital Organization Tokyo Medical Center
  - Meguro-ku, Tokyo, Japan, 153-0051
    - Mishuku Hospital
  - Mitaka, Tokyo, Japan, 181-8611
    - Kyorin University Hospital
  - Sumida-ku, Tokyo, Japan, 130-8575
    - Tokyo Metropolitan Bokutoh Hospital
  - Tachikawa, Tokyo, Japan, 190-0014
    - National Hospital Organization Disaster Medical Center
- Wakayama
  - Tanabe, Wakayama, Japan, 646-8558
    - Minamiwakayama Medical Center
- Yamaguchi
  - Shimonoseki, Yamaguchi, Japan, 750-0061
    - JCHO Shimonoseki Medical center
- Yamanashi
  - Kofu, Yamanashi, Japan, 400-8506
    - Yamanashi Prefectural Central Hospital
Kazakhstan
- - Aktobe, Kazakhstan, 030020
    - Multiprofile regional hospital
  - Almaty, Kazakhstan, 50006
    - City Clinical Hospital No7 - Stroke Unit
  - Astana, Kazakhstan, 160100
    - Multidisciplinary City Hospital No1 - Stroke Unit
Latvia
- - Daugavpils, Latvia, LV-5417
    - Daugavpils Regional Hospital
  - Jēkabpils, Latvia, LV-5201
    - Jekabpils Regional Hospital
  - Riga, Latvia, LV-1002
    - P. Stradins Clinical University Hospital
  - Riga, Latvia, LV-1038
    - Riga East Clinical University Hospital "Gailezers"
  - Rēzekne, Latvia, LV-4601
    - Rezekne Hospital
Lithuania
- - Alytus, Lithuania, LT-62114
    - Alytus County S. Kudirka Hospital
  - Kaunas, Lithuania, LT-50161
    - Hospital of LT University of Health Sciences Kaunas Clinics
  - Vilnius, Lithuania, LT-08661
    - Vilnius University Hospital Santaros Klinikos
  - Vilnius, Lithuania, LT-04130
    - Republican Vilnius University hospital
  - Šiauliai, Lithuania, 76231
    - Siauliai Republican Hospital
Malaysia
- - Kelantan, Malaysia, 15200
    - Hospital Raja Perempuan Zainab Ii
  - Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia
  - Kota Kinabalu, Malaysia, 88586
    - Queen Elizabeth Hospital Malaysia
  - Kuala Lumpur, Malaysia, 50586
    - Hospital Kuala Lumpur
  - Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
  - Kuala Selangor, Malaysia, 43400
    - Hospital Sultan Abdul Aziz Shah
  - Pulau Pinang, Malaysia, 13700
    - Hospital Seberang Jaya
  - Sarawak, Malaysia, 93400
    - Sarawak General Hospital
  - Terengganu, Malaysia, 20400
    - Hospital Sultanah Nur Zahirah Medical Department
Netherlands
- - 's-Hertogenbosch, Netherlands, 5223 GZ
    - Jeroen Bosch Ziekenhuis | Department of Neurology
  - Amsterdam, Netherlands, 1105 AZ
    - Academisch Medisch Centrum (AMC)
  - Amsterdam, Netherlands, 1061 AE
    - OLVG | Location West - Neurology Department
  - Enschede, Netherlands, 7511 JX
    - Medisch Spectrum Twente
  - Heerlen, Netherlands, 6419 PC
    - Zuyderland Medical Centre | Sittard-Geleen - Neurology Department
  - Nieuwegein, Netherlands, 3435 CM
    - St. Antonius Hospital | Nieuwegein - Neurology Department - Stroke Unit
  - Rotterdam, Netherlands, 3079DZ
    - Maasstad Ziekenhuis | Neurology Department
  - The Hague, Netherlands, 2545 AA
    - HagaZiekenhuis | Department of Neurology
  - Utrecht, Netherlands, 3584 CX
    - University Medical Center (UMC) Utrecht | Neurology and Neurosurgery Department
  - Zwolle, Netherlands, 8025 AB
    - Isala Zwolle | Neurology Department
- North Brabant
  - Eindhoven, North Brabant, Netherlands, 5623 EJ
    - Catharina Hospital | Neurology Outpatient Clinic
Norway
- - Bergen, Norway, 5021
    - Haukeland Universitetssykehus Nevrologisk Avdeling
  - Grålum, Norway, 1714
    - Östfold Hospital Trust Fredrikstad
  - Lørenskog, Norway, 1478
    - Akershus Universitetssykehus - Nevrologisk Avdeling
  - Molde, Norway, 6412
    - Molde sykehus Nevrologisk avdeling
  - Oslo, Norway, 450
    - OUS Ullevål Neurology Department
  - Ålesund, Norway, 6017
    - Ålesund sykehus Nevrologisk poliklinikk
Poland
- - Bialystok, Poland, 15-276
    - Uniwersytecki Szpital Kliniczny w Bialymstoku
  - Bydgoszcz, Poland, 85-168
    - Szpital Uniwersytecki Nr 2 im. J. Bizela
  - Gdansk, Poland, 80-803
    - Copernicus PL, M.Kopernik Hospital
  - Grodzisk Mazowiecki, Poland, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. sw. Jana Pawla II
  - Katowice, Poland, 40-635
    - Górnoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach
  - Krakow, Poland, 30-501
    - Szpital Uniwersytecki w Krakowie
  - Krakow, Poland, 31-826
    - Szpital Specjalistyczny im. Rydygiera
  - Lublin, Poland, 20-090
    - Samodzielny Publiczny Szpital Kliniczny nr 4
  - Opole, Poland, 45-221
    - Wojewodzki Szpital Specjalistyczny im. sw. Jadwigi w Opolu
  - Szczecin, Poland, 71-252
    - SP Szpital Kliniczny nr 1 PUM im. Prof. T. Sokolowskiego
  - Warsaw, Poland, 04-141
    - Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
  - Warsaw, Poland, 01-211
    - Szpital Wolski im. dr Anny Gostynskiej SPZOZ
  - Warsaw, Poland, 02-957
    - Instytut Psychiatrii i Neurologii w Warszawie
Portugal
- - Coimbra, Portugal, 3004-561
    - Centro Hospitalar e Universitario de Coimbra | Hospitais da Universidade de Coimbra - Neurology Department
  - Faro, Portugal, 8000-386
    - Centro Hospitalar Universitario do Algarve | Faro - Ensino, Inovacao e Investigacao - Centro de Investigacao e Documentacao
  - Leiria, Portugal, 2410-197
    - Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
  - Lisbon, Portugal, 1449-005
    - Unidade Local De Saúde De Lisboa Ocidental E.P.E.
  - Lisbon, Portugal, 1500-650
    - Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica
  - Lisbon, Portugal, 1649-035
    - CHULN - Hospital Santa Maria
  - Lisbon, Portugal, 1749-004
    - BlueClinical | Centro Hospitalar Baixo Vouga - Unidade Aveiro - Gabinete de Ensaios Clinicos
  - Porto, Portugal, 4200-319
    - Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos
  - Porto, Portugal, 4050-651
    - Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica
- Lisbon District
  - Amadora, Lisbon District, Portugal, 2720-276
    - Hospital Professor Doutor Fernando Fonseca | Neurology Department
- Porto District
  - Matosinhos Municipality, Porto District, Portugal, 4464-513
    - Hospital Pedro Hispano | Clinical Research Center
- Setúbal District
  - Almada, Setúbal District, Portugal, 2805-267
    - Unidade Local de Saude Almada-Seixal | Hospital Garcia de Orta - Research Department
Slovakia
- - Bratislava, Slovakia, 813 69
    - Univerzitna nemocnica Bratislava, Nemocnica Stare Mesto
  - Bratislava, Slovakia, 826 06
    - Univerzitna nemocnica Bratislava, Nemocnica Ruzinov
  - Bratislava, Slovakia, 83305
    - Univerzitna nemocnica Bratislava, Nemocnica ak. L.Derera
  - Dolný Kubín, Slovakia, 026 14
    - Dolnooravska nemocnica s poliklinikou L. Nadasi Jegeho
  - Komárno, Slovakia, 945 05
    - Nemocnica AGEL Komarno s.r.o.
  - Levoča, Slovakia, 05401
    - Vseobecna nemocnica s poliklinikou Levoca, a.s.
  - Liptovský Mikuláš, Slovakia, 03123
    - Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu
  - Martin, Slovakia, 036 59
    - Univerzitná nemocnica Martin
  - Nitra, Slovakia, 950 01
    - Fakultna nemocnica Nitra
  - Prešov, Slovakia, 08181
    - Fakultna nemocnica s poliklinikou J.A. Reimana
  - Rimavská Sobota, Slovakia, 979 12
    - Penta Hospitals | Rimavska Sobota Hospital - Neurology Department
  - Skalica, Slovakia, 909 82
    - Fakultna nemocnica AGEL Skalica, a.s.
  - Spišská Nová Ves, Slovakia, 05201
    - Nemocnica s poliklinikou Spisska Nova Ves a.s.
  - Trnava, Slovakia, 91775
    - Fakultna nemocnica Trnava
  - Vranou Nad Toplou, Slovakia, 09327
    - ProCare Svet Zdravia | Vranov nad Toplou Hospital - Neurology Department
  - Žiar nad Hronom, Slovakia, 965 37
    - Nemocnica AGEL Ziar nad Hronom a Banska Stiavnica s.r.o.
South Korea
- - Busan, South Korea, 49201
    - Dong-A University Hospital
  - Busan, South Korea, 47392
    - Inje University Busan Paik Hospital
  - Daegu, South Korea, 42601
    - Keimyung University Dongsan Medical Center
  - Daejeon, South Korea, 35233
    - Eulji University Hospital
  - Dong-gu, Gwangju, South Korea, 61469
    - Chonnam National University Hospital
  - Incheon, South Korea, TBC
    - Inha University Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 04401
    - Soonchunhyang University Seoul Hospital
  - Seoul, South Korea, 137-701
    - The Catholic University of Korea Seoul St. Mary'S Hospital
  - Seoul, South Korea, 152-703
    - Korea University Guro Hospital
  - Seoul, South Korea, 1830
    - Nowon Eulji Medical Center, Eulji University
  - Seoul, South Korea, 06351
    - Samsung Medical Center-Neurology instead of Cardiology
- Daegu Gwang''yeogsi
  - Daegu, Daegu Gwang''yeogsi, South Korea, 41944
    - Kyungpook National University Hospital
- Gyeonggido
  - Anyang-si, Gyeonggido, South Korea, 14068
    - Hallym University Sacred Heart Hospital
  - Goyang-si, Gyeonggido, South Korea, 411-706
    - Inje University Ilsan Paik Hospital
  - Seongnam-si, Gyeonggido, South Korea, 13620
    - Seoul National University Bundang Hospital
- North Chungcheong
  - Cheongju-si, North Chungcheong, South Korea, 28644
    - Chungbuk National University Hospital
- Seoul Teugbyeolsi
  - Seoul, Seoul Teugbyeolsi, South Korea, 3080
    - Seoul National University Hospital
  - Seoul, Seoul Teugbyeolsi, South Korea, 05505
    - University of Ulsan College of Medicine - Asan Medical Center (AMC) - Cardiology Department
  - Seoul, Seoul Teugbyeolsi, South Korea, 130-872
    - Kyung Hee University Medical Center
  - Seoul, Seoul Teugbyeolsi, South Korea, 03722
    - Severance Hospital, Yonsei University Health System-Neurology instead of Cardiology
Spain
- - Albacete, Spain, 02006
    - Hospital General Universitario De Albacete - Neurologia
  - Barcelona, Spain, 08035
    - Ciutat Sanitaria i Universitaria de la Vall d'Hebron
  - Barcelona, Spain, 08025
    - Hospital de la Santa Creu i Sant Pau | Neurology Department - Stroke, No-Cardioembolic-Tia
  - Girona, Spain, 17007
    - Hospital Universitari De Girona Doctor Josep Trueta - Neurologia
  - León, Spain, 24008
    - Hospital Universitario De Leon - Neurologia
  - Lleida, Spain, 25198
    - Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida - Neurologia
  - Madrid, Spain, 28006
    - COMPLEJO HOSPITALARIO RUBER JUAN BRAVO - Neurología
  - Madrid, Spain, 28006
    - Hospital Universitario de La Princesa | Neurology Department
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz | Neurology Department - Stroke, No-Cardioembolic-Tia
  - Madrid, Spain, 28007
    - H Gregorio Marañon|Neurology|STROKE|NO-CARDIOEMBOLIC-TIA
  - Madrid, Spain, 28041
    - Hospital Universitario 12 de Octubre | Neurology Department - Stroke, No-Cardioembolic-Tia
  - Madrid, Spain, 28034
    - Hospital Universitario Ramon y Cajal - Neurologia
  - Murcia, Spain, 30120
    - Hospital Clinico Universitario Virgen de la Arrixaca | Neurology Department - Stroke
  - Seville, Spain, 41009
    - Hospital Universitario Virgen De La Macarena - Neurologia
  - Seville, Spain, 41013
    - Hospital Universitario Virgen Del Rocio S.L. - Neurologia
  - Tarragona, Spain, 43005
    - Hospital Universitari Joan XXIII De Tarragona - Neurologia
  - Valencia, Spain, 46010
    - Hospital Clinico Universitario de Valencia | Neurology Department
  - Valencia, Spain, 46026
    - Hospital Universitario Y Politecnico La Fe - Neurologia
  - Valladolid, Spain, 47003
    - Hospital Clinico Universitario De Valladolid - Neurologia
- A Coruña
  - A Coruña, A Coruña, Spain, 15006
    - University Hospital of A Coruna | Neurology Department - Stroke, No-Cardioembolic-Tia
  - Santiago de Compostela, A Coruña, Spain, 15706
    - Hospital Clinico Universitario de Santiago de Compostela | Neurology Department - Stroke, No-Cardioembolic-Tia
- Barcelona
  - Badalona, Barcelona, Spain, 08916
    - Hospital Universitari Germans Trias i Pujol
- Madrid
  - Móstoles, Madrid, Spain, 28933
    - Hospital Universitario Rey Juan Carlos - Neurologia
- Pontevedra
  - Babio - Beade, Pontevedra, Spain, 36312
    - Hospital Alvaro Cunqueiro | Neurology Department - Stroke, No-Cardioembolic-Tia
- Vizcaya
  - Barakaldo, Vizcaya, Spain, 48903
    - IIS Biobizkaia Health Research Institute | Hospital de Cruces - Neurology Department - Stroke, No-Cardioembolic-Tia
Sweden
- - Danderyd, Sweden, 18257
    - Danderyds Sjukhus
  - Gothenburg, Sweden, 413 45
    - Sahlgrenska Universitetssjukhuset
  - Lund, Sweden, 221 85
    - Skanes universitetssjukhus
  - Stockholm, Sweden, 141 86
    - Karolinska University Hospital
  - Stockholm, Sweden, 118 83
    - Sodersjukhuset AB
  - Stockholm, Sweden, 141 86
    - Karolinska University Hospital, Huddinge Neuroradiology
  - Uppsala, Sweden, 752 85
    - Akademiska Sjukhuset
  - Östersund, Sweden, 831 83
    - Östersunds Sjukhus
Switzerland
- - Bern, Switzerland, 3010
    - INSELSPITAL Universitätsspital Bern
  - Villars-sur-Glâne, Switzerland, 1752
    - Hospital Cantonal Fribourg
  - Zurich, Switzerland, 8032
    - NeuroZentrum Hirslanden
- Canton Ticino
  - Lugano, Canton Ticino, Switzerland, 6900
    - Ospedale Regionale di Lugano
- Canton of Aargau
  - Baden, Canton of Aargau, Switzerland, 5404
    - Kantonsspital Baden
- Canton of Basel-City
  - Basel, Canton of Basel-City, Switzerland, 4056
    - Universitatsspital Basel
- Canton of Geneva
  - Geneva, Canton of Geneva, Switzerland, 1205
    - Hôpital Cantonal Universitaire de Genève
- Canton of St. Gallen
  - Sankt Gallen, Canton of St. Gallen, Switzerland, 1009
    - Kantonsspital St. Gallen
- Canton of Vaud
  - Lausanne, Canton of Vaud, Switzerland, 1011
    - Centre Hospitalier Universitaire Vaudois (CHUV)
Taiwan
- - Changhua, Taiwan, 50006
    - Changhua Christian Hospital
  - Hsinchu, Taiwan, 302
    - National Taiwan University Hospital, Hsin-Chu Branch
  - Kaohsiung City, Taiwan, 813414
    - Kaohsiung Veterans General Hospital
  - Kaohsiung City, Taiwan, 833
    - Chang Gung Memorial Hospital Kaohsiung
  - Keelung, Taiwan, 20401
    - Chang Gung Memorial Hospital Keelung
  - New Taipei City, Taiwan, 23561
    - Taipei Medical University - Shuang Ho Hospital
  - Taichung, Taiwan, 40705
    - Taichung Veterans General Hospital
  - Taichung, Taiwan, 404327
    - China Medical University Hospital
  - Taichung, Taiwan, 402306
    - Chung Shan Medical University Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Tainan, Taiwan, 736
    - Chi-Mei Medical Center, Liouyine
  - Taipei, Taiwan, 100
    - National Taiwan University Hospital
  - Taipei, Taiwan, 104
    - Mackay Memorial Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 114
    - Tri-Service General Hospital
  - Taipei, Taiwan, 111
    - Shin Kong Wu Ho-Su Memorial Hospital
  - Taipei, Taiwan, 116
    - Taipei Municipal Wanfang Hospital
  - Taoyuan District, Taiwan, 33305
    - Chang Gung Memorial Hospital at Linkou
- Hsinchu
  - Zhubei, Hsinchu, Taiwan, 302
    - China Medical University Hospital Hsin-Chu Branch
- Kaohsiung
  - Kaohsiung City, Kaohsiung, Taiwan, 807377
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
- Taipei
  - New Taipei City, Taipei, Taiwan, 25160
    - Mackay Memorial Hospital Tamsui Branch
  - New Taipei City, Taipei, Taiwan, 220
    - Far Eastern Memorial Hospital Neurology
  - New Taipei City, Taipei, Taiwan, 237
    - En Chu Kong Hospital
  - New Taipei City, Taipei, Taiwan, 24352
    - Fu Jen Catholic University Hospital
Turkey (Türkiye)
- - Ankara, Turkey (Türkiye), 6800
    - Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital
  - Ankara, Turkey (Türkiye), 6100
    - Ankara Universitesi Tip Fakultesi Hastanesi
  - Ankara, Turkey (Türkiye), 6100
    - Hacettepe Universitesi Tip Fakultesi
  - Ankara, Turkey (Türkiye), 6560
    - Gazi Universitesi Tip Fakultesi
  - Antalya, Turkey (Türkiye), 7059
    - Akdeniz Universitesi Tip Fakultesi Hastanesi
  - Elâzığ, Turkey (Türkiye), 23119
    - Firat Universitesi Tip Fakultesi
  - Eskişehir, Turkey (Türkiye), 26480
    - Eskisehir Osmangazi Universitesi Tip Fakultesi
  - Istanbul, Turkey (Türkiye), 34093
    - Istanbul Universitesi Istanbul Tip Fakultesi
  - Istanbul, Turkey (Türkiye), 34147
    - Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi ve Sinir Hast. EAH
  - Istanbul, Turkey (Türkiye), 34668
    - Istanbul Sultan 2. Abdulhamid Han Egitim ve Arastirma Has.
  - Istanbul, Turkey (Türkiye), 34865
    - Kartal Dr Lutfi Kirdar sehir Hastanesi
  - Istanbul, Turkey (Türkiye), 34899
    - Marmara Uni. Tip Fak. Pendik EAH Noroloji
  - Izmir, Turkey (Türkiye), 35340
    - Dokuz Eylul Universitesi Tip Fakultesi
  - Izmir, Turkey (Türkiye), 35100
    - Ege Universitesi Tip Fakultesi
  - Izmir, Turkey (Türkiye), 64300
    - Saglik Bilimleri Universitesi Izmir Tepecik EAH
  - Kayseri, Turkey (Türkiye), 38039
    - Erciyes Universitesi Tip Fakultesi
  - Konya, Turkey (Türkiye), 42080
    - Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi
  - Konya, Turkey (Türkiye), 42075
    - Selçuk University Faculty of Medicine
  - Samsun, Turkey (Türkiye), 55090
    - Samsun Egitim Arastirma Hastanesi
  - Samsun, Turkey (Türkiye), 55139
    - Ondokuz Mayis Uni Tip Fakultesi
  - Sivas, Turkey (Türkiye), 58140
    - Cumhuriyet Universitesi Tip Fakultesi
United Kingdom
- - Derby, United Kingdom, DE22 3NE
    - University Hospitals of Derby and Burton NHS Foundation Trust | Royal Derby Hospital - Cardiology
  - Edinburgh, United Kingdom, EH3 9YW
    - Edinburgh Royal Infirmary
  - Exeter, United Kingdom, EX2 5DW
    - Royal Devon University Healthcare NHS Foundation Trust | Royal Devon and Exeter Hospital - Stroke Unit
  - Glasgow, United Kingdom, G31 2ER
    - NHS Greater Glasgow and Clyde | Glasgow Royal Infirmary |Glasgow Research Facility - Cardiology
  - Liverpool, United Kingdom, L9 7AL
    - Liverpool University Hospitals NHS Foundation Trust | Aintree University Hospital - Stroke Unit
  - London, United Kingdom, W6 8RF
    - Charing Cross Hospital
  - London, United Kingdom, SE5 8AF
    - King's College Hospital NHS Foundation Trust | King's College Hospital - Academic Neuroscience Centre
  - Oxford, United Kingdom, OX3 9DU
    - John Radcliffe Hospital
- Hampshire
  - Southampton, Hampshire, United Kingdom, SO16 6YD
    - Southampton General Hospital
- Kent
  - Canterbury, Kent, United Kingdom, CT1 3NG
    - East Kent Hospitals University NHS Foundation Trust | Kent and Canterbury Hospital - Stroke Unit
- London
  - Kogarah, London, United Kingdom, 2217
    - St George's University Hospitals NHS Foundation Trust | St George's Hospital | Neurology Department
- Manchester
  - Salford, Manchester, United Kingdom, M6 8HD
    - Northern Care Alliance NHS Foundation Trust | Salford Royal Hospital - Clinical Research Facility
- Staffordshire
  - Stoke-on-Trent, Staffordshire, United Kingdom, ST4 6QG
    - Royal Stoke University Hospital
- Tyne and Wear
  - Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP
    - The Newcastle upon Tyne Hospitals NHS Foundation Trust | Royal Victoria Infirmary - Acute Stroke Unit
  - Sunderland, Tyne and Wear, United Kingdom, SR4 7TP
    - South Tyneside and Sunderland NHS Foundation Trust | Sunderland Royal Hospital - Acute Stroke Unit
- West Yorkshire
  - Leeds, West Yorkshire, United Kingdom, LS1 3EX
    - Leeds Teaching Hospitals NHS Trust | Leeds General Infirmary - Cardiology
United States
- Alabama
  - Fairhope, Alabama, United States, 36532
    - Eastern Shore Research Institute, LLC | Fairhope, AL
- Arizona
  - Phoenix, Arizona, United States, 85013
    - Barrow Neurologic Institute - Petznick Stroke Center
  - Scottsdale, Arizona, United States, 85258
    - HonorHealth Research Institute
  - Tucson, Arizona, United States, 85724
    - Banner - University Medical Center Tucson - Neurology
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - University of Arkansas for Medical Sciences - Neurology
- California
  - Fontana, California, United States, 92335
    - Kaiser Permanente Fontana Medical Center
  - Long Beach, California, United States, 90806
    - Long Beach Medical Center - Neurology
  - Los Angeles, California, United States, 90027
    - Kaiser Permanente Los Angeles Medical Center - Neurology
  - Los Angeles, California, United States, 90095
    - UCLA NeuroTranslational Research Center
  - Los Angeles, California, United States, 90033
    - Los Angeles - USC Healthcare Center 2 - Neurology
  - Newport Beach, California, United States, 92663
    - Hoag Memorial Hospital - Center for Research & Education
  - Orange, California, United States, 92868
    - UCI Medical Center - Neurology
  - San Francisco, California, United States, 94121
    - San Francisco VA Health Care System
  - Santa Barbara, California, United States, 93105
    - Cottage Health | Santa Barbara Cottage Hospital - Research Department
  - Torrance, California, United States, 90502
    - The Lundquist Institute - Neurology
- Connecticut
  - Bridgeport, Connecticut, United States, 06606
    - St. Vincent's Medical Center - Neurology Clinic
  - Danbury, Connecticut, United States, 06810
    - Nuvance Health
  - New Haven, Connecticut, United States, 06519
    - Yale University | School of Medicine - Department of Neurology
- Delaware
  - Newark, Delaware, United States, 19718
    - ChristianaCare Health Services | Christiana Hospital - Emergency Medicine Research
- Florida
  - Atlantis, Florida, United States, 33462
    - HCA Florida JFK Hospital - Neurology
  - Boynton Beach, Florida, United States, 33472
    - Delray Medical Center - Neurology
  - Bradenton, Florida, United States, 34209
    - Nova Clinical Research - Blake Medical Center
  - Clearwater, Florida, United States, 33756
    - BayCare Health System | Morton Plant Hospital - Neuroscience Research department
  - Gainesville, Florida, United States, 32608
    - UF Health Neuromedicine Hospital
  - Jacksonville, Florida, United States, 32207
    - Baptist Health Research Institute
  - Sarasota, Florida, United States, 34239
    - Intercoastal Medical Group | Clinical Research
  - Tampa, Florida, United States, 33607
    - BayCare Health System | Saint Joseph's Hospital - Neurology Department
  - Tampa, Florida, United States, 33606
    - USF Health South Tampa Center for Advanced Healthcare - Neurology
- Illinois
  - Chicago, Illinois, United States, 60637
    - The University of Chicago Medical Center - Neurology
  - Chicago, Illinois, United States, 60612
    - University of Illinois Hospital - Neurology
  - Maywood, Illinois, United States, 60153
    - Loyola University Medical Center - Neurology
  - Rockford, Illinois, United States, 61114
    - Mercyhealth Javon Bea Hospital - Riverside | Neurology Research Department
  - Springfield, Illinois, United States, 62769
    - HSHS St. John's Hospital - Neurology
- Kentucky
  - Lexington, Kentucky, United States, 40503
    - Baptist Health Lexington
- Louisiana
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Medical Center - New Orleans - Neurology
- Maryland
  - Baltimore, Maryland, United States, 21201
    - University of Maryland Medical Center - Neurology Care Center
- Massachusetts
  - Boston, Massachusetts, United States, 02111
    - Tufts Medical Center - Neurology
- Michigan
  - Detroit, Michigan, United States, 48202
    - Henry Ford Hospital - Neurology
  - East Lansing, Michigan, United States, 48824
    - MSU Health Care Neurology & Ophthalmology
  - Pontiac, Michigan, United States, 48341
    - Trinity Health | Oakland Hospital - Clinical Research Department
- Minnesota
  - Golden Valley, Minnesota, United States, 55422
    - Minneapolis Clinic of Neurology | Golden Valley, MN
  - Rochester, Minnesota, United States, 55902
    - Mayo Clinic - Rochester - Neurology
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - University Hospital - UMMC - Neurology
- Missouri
  - Kansas City, Missouri, United States, 64128
    - Kansas City VA Medical Center - Neurology
  - Kansas City, Missouri, United States, 64111
    - Saint Luke's Hospital of Kansas City - Neurology
  - St Louis, Missouri, United States, 63100
    - Barnes-Jewish Hospital - Cardiology
  - St Louis, Missouri, United States, 63141
    - Mercy Research - St. Louis
- New Hampshire
  - Lebanon, New Hampshire, United States, 03756
    - Dartmouth-Hitchcock Medical Center - Neurology
- New Jersey
  - Hackensack, New Jersey, United States, 07601
    - Hackensack University Medical Center
- New York
  - Albany, New York, United States, 12208
    - Albany Medical College | Department of Neurology
  - Brooklyn, New York, United States, 11234
    - Mount Sinai Brooklyn - Neurology
  - Brooklyn, New York, United States, 11220
    - NYU Langone Hospital Brooklyn - Neurology
  - Brooklyn, New York, United States, 11203
    - SUNY Downstate Health Sciences University - Neurology
  - Buffalo, New York, United States, 14220
    - Trinity Medical Western New York | Trinity Vascular & Endovascular Center - Research Department
  - Great Neck, New York, United States, 11021
    - Neuroscience Institute at Great Neck
  - Hawthorne, New York, United States, 10532
    - Westchester Medical Center
  - New York, New York, United States, 10032
    - The Neurological Institute - Columbia University Irving Medical Center
  - New York, New York, United States, 33756
    - Mount Sinai Hospital - Stroke Center
  - Poughkeepsie, New York, United States, 12601
    - Vassar Brothers Medical Center
  - Rochester, New York, United States, 14621
    - Rochester General Hospital
- North Carolina
  - Asheville, North Carolina, United States, 28801
    - Mission Hospital | Neurology
  - Durham, North Carolina, United States, 27710
    - Duke Neurological Disorders Clinic - Clinic 1L
  - Greensboro, North Carolina, United States, 27405
    - Guilford Neurologic Research Partners, LLC.
  - Greenville, North Carolina, United States, 27834
    - ECU Health Medical Center - Neurology
  - Raleigh, North Carolina, United States, 27607
    - North Carolina Heart & Vascular (Capital Heart)
  - Winston-Salem, North Carolina, United States, 27157
    - Atrium Health Wake Forest Baptist | Medical Center - Neurology Department
  - Winston-Salem, North Carolina, United States, 27103
    - Novant Health Forsyth Medical Center - Neurology
- Ohio
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic - Neurology
  - Columbus, Ohio, United States, 43210
    - Ohio State University Wexner Medical Center - Neurology
  - Columbus, Ohio, United States, 43214
    - OhioHealth Neuroscience Center at Riverside
  - Dayton, Ohio, United States, 45409
    - Wright State University | Boonshoft School of Medicine - WSU and Premier Health Clinical Trials Research Alliance
  - Kettering, Ohio, United States, 45429
    - Kettering Health Main Campus - Neurology
  - Lima, Ohio, United States, 45801
    - Mercy Health - St. Rita's Medical Center - Neurology
  - Toledo, Ohio, United States, 43606
    - ProMedica | ProMedica Toledo Hospital - Neuro/Stroke Research Department
  - Toledo, Ohio, United States, 43608
    - Mercy Health St. Vincent Medical Center - Neurology
  - Youngstown, Ohio, United States, 44504
    - Mercy Health St. Elizabeth Youngstown Hospital - Neurology
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, United States, 73104
    - OU Health University of Oklahoma Med Center - Neurology
- Oregon
  - Portland, Oregon, United States, 97239
    - OHSU Hospital - Neurology
- Pennsylvania
  - Allentown, Pennsylvania, United States, 18103
    - LVH Neurology - 1250 Cedar Crest
  - Erie, Pennsylvania, United States, 16507
    - University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research
  - Harrisburg, Pennsylvania, United States, 17101
    - UPMC Harrisburg - Cardiology
  - Hershey, Pennsylvania, United States, 17033
    - Penn State Milton S. Hershey Medical Center - Neurology
  - Lancaster, Pennsylvania, United States, 17601
    - Lancaster General Health Neuroscience Institute
  - Philadelphia, Pennsylvania, United States, 19107
    - Jefferson Hospital for Neuroscience
  - Philadelphia, Pennsylvania, United States, 19140
    - Lewis Katz School of Medicine at Temple University | Neurology
  - Philadelphia, Pennsylvania, United States, 19141
    - Jefferson Einstein Philadelphia Hospital - Neurology
  - Philadelphia, Pennsylvania, United States, 19104
    - Hospital of the University of Pennsylvania - Neurology
- Rhode Island
  - Providence, Rhode Island, United States, 20903
    - Rhode Island Hospital - Neurology
- South Carolina
  - Charleston, South Carolina, United States, 29425
    - MUSC Health Neurology at Rutledge Tower
  - Greenville, South Carolina, United States, 29605
    - Prisma Health Greenville Memorial Hospital - Comprehensive Stroke Center
- Tennessee
  - Chattanooga, Tennessee, United States, 37403
    - Erlanger Neurology
  - Knoxville, Tennessee, United States, 37920
    - The University of Tennessee Medical Center - Main Campus - Neurology
  - Memphis, Tennessee, United States, 38120
    - Baptist Memorial Hospital East - Cardiology
- Texas
  - Dallas, Texas, United States, 75204
    - Baylor University Medical Center at Dallas - Neurology
  - Dallas, Texas, United States, 75390
    - James W. Aston Ambulatory Care Center - Neurology
  - Edinburg, Texas, United States, 78539
    - Doctors Hospital at Renaissance - Neurology
  - Fort Worth, Texas, United States, 76104
    - Texas Health Harris Methodist Hospital - Fort Worth - Neurology
  - Houston, Texas, United States, 77030
    - Houston Methodist Neurological Institute
  - Houston, Texas, United States, 77030
    - UTHealth Houston Neurosciences Neurology - Texas Medical Center
  - Plano, Texas, United States, 75093
    - Neurology Consultants of Dallas - Plano
  - San Antonio, Texas, United States, 78229
    - UT Health San Antonio - Medical Arts & Research Center - Neurology
  - Temple, Texas, United States, 76508
    - Baylor Scott & White Medical Center - Temple - Neurology
- Utah
  - Murray, Utah, United States, 84107
    - Intermountain Cardiovascular Research Department
  - Salt Lake City, Utah, United States, 84312
    - University of Utah Clinical Neurosciences Center
- Virginia
  - Henrico, Virginia, United States, 23229
    - Neurological Associates - Henrico
- West Virginia
  - Huntington, West Virginia, United States, 25701
    - Marshall University Medical Center - Neurology
- Wisconsin
  - Milwaukee, Wisconsin, United States, 53226
    - Froedtert Hospital - Neurology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Participants must be ≥ 18 years of age
Acute non-cardioembolic stroke or high-risk TIA
Systemic or cerebrovascular atherosclerosis or acute non-lacunar infarct

Exclusion Criteria:

Ischemic stroke ≤ 7 days before the index event
Index stroke following procedures or strokes due to other rare causes
History of atrial fibrillation/flutter, left ventricular thrombus, mechanic valve or other cardioembolic source of stroke requiring anticoagulation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Participants will receive placebo.	Drug: Placebo Placebo to asundexian, once daily, oral
Experimental: Asundexian Participants will receive asundexian.	Drug: Asundexian (BAY2433334) Once daily, oral

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of ischemic stroke Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of ISTH major bleeding Time Frame: Up to 31 months	ISTH=International Society on Thrombosis and Hemostasis	Up to 31 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of all strokes (ischemic and hemorrhagic) Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of composite of CV death, MI or stroke Time Frame: Up to 31 months	CV=Cardiovascular, MI=Myocardial infarction	Up to 31 months
Time to first occurrence of composite of all-cause mortality, MI or stroke Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of disabling stroke (mRS ≥3 at 90 days) Time Frame: Up to 31 months	mRS=Modified Rankin Scale	Up to 31 months
Time to first occurrence of all-cause mortality Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of transient ischemic attack (TIA) Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of composite of ISTH major or clinically relevant non-major bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of ISTH clinically relevant non-major bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of symptomatic intracranial hemorrhage Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of hemorrhagic stroke Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of fatal bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of minor bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of composite of ischemic stroke or ISTH major bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of composite of CV death, all stroke, MI or ISTH major bleeding Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of composite of all-cause mortality, disabling stroke, fatal bleeding, symptomatic intracranial hemorrhage Time Frame: Up to 31 months		Up to 31 months
Time to first occurrence of ischemic stroke in the first 90 days Time Frame: Up to 31 months		Up to 31 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bayer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Click here to find further information and, after study completion, the study results according to Bayer's transparency standards

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 26, 2023

Primary Completion (Actual)

October 23, 2025

Study Completion (Actual)

October 23, 2025

Study Registration Dates

First Submitted

January 6, 2023

First Submitted That Met QC Criteria

January 6, 2023

First Posted (Actual)

January 17, 2023

Study Record Updates

Last Update Posted (Actual)

November 12, 2025

Last Update Submitted That Met QC Criteria

November 10, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

20604
2022-001067-27 (EudraCT Number)
2023-503793-20-00 (Other Identifier: CTIS (EU))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014.

Interested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Acute Non-cardioembolic Ischemic Stroke

Bayer
Population Health Research Institute

Completed

Study to Gather Information About Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following a Recent Non Cardioembolic Ischemic Stroke Which Occurs When a Blood Clot Has Formed Somewhere in the Human Body (But Not in the Heart) Travelled to the Brain. (PACIFIC-STROKE)

Acute Non-cardioembolic Ischemic Stroke

Spain, Japan, Australia, Czechia, Sweden, United Kingdom, Netherlands, Belgium, Russian Federation, Hungary, Slovakia, China, Germany, Switzerland, France, Poland, Denmark, United States, Austria, Bulgaria, Finland, Italy, Portugal
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Acute Ischemic Stroke: an Individual Patient Data Meta-Analysis (AIS of HEARTS)

Ischemic Stroke | Thrombus | Cardioembolic Stroke | Cardiac CT

Netherlands
Bayer

Completed

A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function

Atrial Fibrillation | Hepatic Impairment | Acute Myocardial Infarction | Prevention of Thromboembolic Events | Non-cardioembolic Ischemic Stroke

Germany
Ischemia Care LLC

Recruiting

Biomarkers of Acute Stroke in Clinic (BASIC)

Ischemia | Stroke | Ischemic Stroke | Atherosclerosis | Atrial Fibrillation | Transient Ischemic Attack | Cardiomyopathies | Thromboembolism | Stroke, Ischemic | Stroke, Acute | Thrombotic Stroke | Stroke, Complication | Cardioembolic Stroke | Cardiovascular Stroke | Atheroma | Stroke of Basilar Artery | Transient Cerebrovascular...

United States
Hospital Mutua de Terrassa

Unknown

Dabigatran Study in the Early Phase of Stroke. New Neuroimaging Markers and Biomarkers Study (SEDMAN STUDY) (SEDMAN)

Cardioembolic Stroke

Spain
Xiao Huang

Active, not recruiting

A Real-world Registry Study of Multidisciplinary Collaborative Diagnosis and Treatment Model for Cardioembolic Stroke (CSMDT)

Multidisciplinary Communication | Cardioembolic Stroke

China
University Hospital Heidelberg

Completed

Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior? (BEST)

Acute Ischemic Stroke | Acute Ischemic Stroke AIS | Acute Ischemic Stroke Patients

Germany
Ischemia Care LLC

Completed

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE) (BASE)

Ischemic Stroke | Atrial Fibrillation | Thrombotic Stroke | Transient Ischemic Attacks | Cardioembolic Stroke | Stroke of Basilar Artery | Transient Cerebrovascular Events

United States
University of Calgary
The George Institute for Global Health, Australia

Recruiting

ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 (ACT-WHEN)

Acute Ischemic Stroke AIS | Stroke, Acute, Stroke Ischemic | Stroke Acute

Canada, Australia
University of Miami

No longer available

Expanded Access Multi-Patient Experimental Treatment Involving Allogeneic Human Mesenchymal Stem Cells (hMSCs) in Subjects With Acute Ischemic Stroke (EXPAND) (EXPAND)

Stroke, Ischemic | Stroke, Acute | Mesenchymal Stem Cells | Acute Ischemic Stroke | Stroke/Brain Attack

United States

Clinical Trials on Asundexian (BAY2433334)

Bayer

Completed

A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function

Atrial Fibrillation | Hepatic Impairment | Acute Myocardial Infarction | Prevention of Thromboembolic Events | Non-cardioembolic Ischemic Stroke

Germany
Bayer

Terminated

A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke (OCEANIC-AF)

Atrial Fibrillation | Prevention of Stroke or Systemic Embolism

Canada, United States, Korea, Republic of, China, Taiwan, Belgium, Australia, Finland, Singapore, Malaysia, Slovakia, United Kingdom, Czechia, Latvia, Japan, Lithuania, Germany, France, Sweden, Turkey, Switzerland, Estonia, Italy, Greece and more
Bayer

Completed

Study to Gather Information About the Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following an Acute Heart Attack (PACIFIC-AMI)

Acute Myocardial Infarction

Spain, Japan, Belgium, United States, Czechia, Hungary, Switzerland, Netherlands, Germany, Austria, Poland, Italy, Sweden, United Kingdom
Bayer
Population Health Research Institute

Completed

Study to Gather Information About Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following a Recent Non Cardioembolic Ischemic Stroke Which Occurs When a Blood Clot Has Formed Somewhere in the Human Body (But Not in the Heart) Travelled to the Brain. (PACIFIC-STROKE)

Acute Non-cardioembolic Ischemic Stroke

Spain, Japan, Australia, Czechia, Sweden, United Kingdom, Netherlands, Belgium, Russian Federation, Hungary, Slovakia, China, Germany, Switzerland, France, Poland, Denmark, United States, Austria, Bulgaria, Finland, Italy, Portugal
Bayer

Completed

Study to Assess the Safety, Tolerability, Effects on the Body, Absorption, Distribution and Elimination of 25 mg BAY2433334 in Renal Impairment Including Renal Replacement Therapy ("Dialysis")

Prevention of Thromboembolic Events

Germany
Bayer

Completed

Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban, a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications. (PACIFIC-AF)

Atrial Fibrillation (AF)

Spain, Belgium, Latvia, Italy, Switzerland, Canada, Austria, Japan, Czechia, Hungary, Netherlands, Sweden, France, United Kingdom

A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (OCEANIC-STROKE)

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Acute Non-cardioembolic Ischemic Stroke

Clinical Trials on Asundexian (BAY2433334)

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Bulgaria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations