A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy (CAMBRIA-1)

May 7, 2026 updated by: AstraZeneca

CAMBRIA-1: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Cancer and an Intermediate or High Risk of Recurrence Who Have Completed Definitive Locoregional Therapy and at Least 2 Years of Standard Adjuvant Endocrine-Based Therapy Without Disease Recurrence

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy) and standard adjuvant endocrine therapy (ET) for at least 2 years and up to 5 years. The planned duration of treatment in either arm of the study is 60 months.

Study Overview

Status

Recruiting

Conditions

Breast Cancer, Early Breast Cancer

Intervention / Treatment

Detailed Description

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer who completed definitive locoregional therapy (with or without chemotherapy) and standard adjuvant endocrine therapy (ET) for at least 2 years and up to 5 years. The planned duration of treatment in either arm of the study is 60 months. The eligible patients must have intermediate or high risk of recurrence, as defined by specified clinical and biologic criteria. Prior use of CDK4/6 inhibitors is permitted. The primary endpoint of the study is Invasive breast cancer-free survival (IBCFS) and main secondary endpoints include Invasive disease-free survival (IDFS), Distant relapse-free survival (DRFS), Overall survival (OS), Safety and Clinical Outcome Assessments (COAs).

Patients will be followed for 10 years from randomization of the last patient.

Study Type

Interventional

Enrollment (Estimated)

4300

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: AstraZeneca Clinical Study Information Center
Phone Number: 1-877-240-9479
Email: information.center@astrazeneca.com

Study Contact Backup

Name: AstraZeneca Breast Cancer Study Locator Service
Phone Number: 1-877-400-4655
Email: az-bcsl@careboxhealth.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1430EGF
    - Withdrawn
    - Research Site
  - CABA, Argentina, C1119ACN
    - Active, not recruiting
    - Research Site
  - Capital Federal, Argentina, C1417DTB
    - Active, not recruiting
    - Research Site
  - Ciudad Autónoma Buenos Aires, Argentina, 1125
    - Active, not recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, 1280
    - Active, not recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, C1118AAT
    - Active, not recruiting
    - Research Site
  - Ciudad de Buenos Aires, Argentina, C1426ANZ
    - Active, not recruiting
    - Research Site
  - Córdoba, Argentina, 5000
    - Active, not recruiting
    - Research Site
  - Córdoba, Argentina, 5001
    - Active, not recruiting
    - Research Site
  - La Plata, Argentina, 1900
    - Active, not recruiting
    - Research Site
  - Mar del Plata, Argentina, 7600
    - Active, not recruiting
    - Research Site
  - Salta, Argentina, A4400EMI
    - Withdrawn
    - Research Site
  - San Juan, Argentina, 5400
    - Active, not recruiting
    - Research Site
  - San Miguel de Tucumán, Argentina, 4000
    - Active, not recruiting
    - Research Site
  - San Miguel de Tucumán, Argentina, T4000IAK
    - Active, not recruiting
    - Research Site
  - Viedma, Argentina, R8500ACE
    - Active, not recruiting
    - Research Site
Australia
- - Birtinya, Australia, 4575
    - Active, not recruiting
    - Research Site
  - Concord, Australia, 2139
    - Active, not recruiting
    - Research Site
  - Nedlands, Australia, 6009
    - Active, not recruiting
    - Research Site
  - Nedlands, Australia, 6009
    - Withdrawn
    - Research Site
  - Randwick, Australia, 2031
    - Active, not recruiting
    - Research Site
  - Tweed Heads, Australia, 2485
    - Withdrawn
    - Research Site
  - Waratah, Australia, 2298
    - Active, not recruiting
    - Research Site
  - Wendouree, Australia, 3355
    - Active, not recruiting
    - Research Site
Austria
- - Graz, Austria, 8036
    - Active, not recruiting
    - Research Site
  - Kufstein, Austria, 6330
    - Active, not recruiting
    - Research Site
  - Ried, Austria, 4910
    - Withdrawn
    - Research Site
  - Sankt Veit an der Glan, Austria, 9300
    - Active, not recruiting
    - Research Site
  - Vienna, Austria, 1090
    - Active, not recruiting
    - Research Site
  - Vienna, Austria, 1180
    - Withdrawn
    - Research Site
  - Wein, Austria, 1130
    - Active, not recruiting
    - Research Site
  - Wels, Austria, 4600
    - Active, not recruiting
    - Research Site
Belgium
- - Brussels, Belgium, 1090
    - Active, not recruiting
    - Research Site
  - Edegem, Belgium, 2650
    - Recruiting
    - Research Site
  - Ghent, Belgium, 9000
    - Active, not recruiting
    - Research Site
  - Leuven, Belgium, 8500
    - Active, not recruiting
    - Research Site
  - Liège, Belgium, 4000
    - Active, not recruiting
    - Research Site
  - Ottignies, Belgium, 1340
    - Active, not recruiting
    - Research Site
  - Wilrijk, Belgium, 2610
    - Active, not recruiting
    - Research Site
  - Yvoir, Belgium, 5530
    - Active, not recruiting
    - Research Site
Brazil
- - Alfenas, Brazil, 37130-000
    - Active, not recruiting
    - Research Site
  - Belo Horizonte, Brazil, 30150-274
    - Active, not recruiting
    - Research Site
  - Belo Horizonte, Brazil, 30130-100
    - Active, not recruiting
    - Research Site
  - Brasília, Brazil, 71681-603
    - Active, not recruiting
    - Research Site
  - Brasília, Brazil, 70390-700
    - Withdrawn
    - Research Site
  - Chapecó, Brazil, 89812-220
    - Active, not recruiting
    - Research Site
  - Cuiabá, Brazil, 78040-400
    - Terminated
    - Research Site
  - Curitiba, Brazil, 81520-060
    - Recruiting
    - Research Site
  - Curitiba, Brazil, 80810-050
    - Active, not recruiting
    - Research Site
  - Fortaleza, Brazil, 60430-230
    - Active, not recruiting
    - Research Site
  - Fortaleza, Brazil, 60170-170
    - Active, not recruiting
    - Research Site
  - Lajeado, Brazil, 95900000
    - Active, not recruiting
    - Research Site
  - Londrina, Brazil, 86015-520
    - Recruiting
    - Research Site
  - Natal, Brazil, 59075-740
    - Active, not recruiting
    - Research Site
  - Niterói, Brazil, 24020-096
    - Active, not recruiting
    - Research Site
  - Piracicaba, Brazil, 13419-155
    - Active, not recruiting
    - Research Site
  - Porto Alegre, Brazil, 90035-903
    - Active, not recruiting
    - Research Site
  - Porto Alegre, Brazil, 90050-170
    - Active, not recruiting
    - Research Site
  - Porto Alegre, Brazil, 90035-001
    - Active, not recruiting
    - Research Site
  - Porto Alegre, Brazil, 90880-480
    - Active, not recruiting
    - Research Site
  - Pouso Alegre, Brazil, 37554-216
    - Active, not recruiting
    - Research Site
  - Recife, Brazil, 50070-070
    - Active, not recruiting
    - Research Site
  - Ribeirão Preto, Brazil, 14051-140
    - Active, not recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 20560-120
    - Active, not recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 22250-905
    - Active, not recruiting
    - Research Site
  - Rio de Janeiro, Brazil, 22290-160
    - Recruiting
    - Research Site
  - Salvador, Brazil, 41253-190
    - Active, not recruiting
    - Research Site
  - Salvador, Brazil, 40110-060
    - Withdrawn
    - Research Site
  - São Paulo, Brazil, 08270-070
    - Active, not recruiting
    - Research Site
  - São Paulo, Brazil, 01323-001
    - Active, not recruiting
    - Research Site
  - São Paulo, Brazil, 01317-001
    - Active, not recruiting
    - Research Site
  - São Paulo, Brazil, 01508-010
    - Active, not recruiting
    - Research Site
  - São Paulo, Brazil, 01509-900
    - Active, not recruiting
    - Research Site
  - São Paulo, Brazil, 01236-030
    - Active, not recruiting
    - Research Site
  - Taubaté, Brazil, 12030-200
    - Recruiting
    - Research Site
  - Três Lagoas, Brazil, 79601-001
    - Active, not recruiting
    - Research Site
  - Vitória, Brazil, 29055-450
    - Active, not recruiting
    - Research Site
Bulgaria
- - Dobrich, Bulgaria, 9300
    - Active, not recruiting
    - Research Site
  - Plovdiv, Bulgaria, 4002
    - Withdrawn
    - Research Site
  - Plovdiv, Bulgaria, 4004
    - Active, not recruiting
    - Research Site
  - Sofia, Bulgaria, 1431
    - Withdrawn
    - Research Site
  - Sofia, Bulgaria, 1606
    - Withdrawn
    - Research Site
  - Sofia, Bulgaria, 1330
    - Active, not recruiting
    - Research Site
  - Sofia, Bulgaria, 1407
    - Active, not recruiting
    - Research Site
  - Sofia, Bulgaria, 1784
    - Terminated
    - Research Site
  - Vratsa, Bulgaria, 3000
    - Withdrawn
    - Research Site
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Withdrawn
    - Research Site
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - Active, not recruiting
    - Research Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - Active, not recruiting
    - Research Site
- Ontario
  - Barrie, Ontario, Canada, L4M 6M2
    - Active, not recruiting
    - Research Site
  - Ottawa, Ontario, Canada, K1H 8L6
    - Withdrawn
    - Research Site
  - Sault Ste. Marie, Ontario, Canada, P6A 0A8
    - Active, not recruiting
    - Research Site
  - Toronto, Ontario, Canada, M5G 1X5
    - Active, not recruiting
    - Research Site
  - Windsor, Ontario, Canada, N8W 2X3
    - Active, not recruiting
    - Research Site
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - Active, not recruiting
    - Research Site
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - Active, not recruiting
    - Research Site
  - Montreal, Quebec, Canada, H1T 2M4
    - Active, not recruiting
    - Research Site
  - Montreal, Quebec, Canada, H2X 3E4
    - Active, not recruiting
    - Research Site
  - Montreal, Quebec, Canada, H4A 3J1
    - Active, not recruiting
    - Research Site
  - Saint-Jérôme, Quebec, Canada, J7Z 5T3
    - Active, not recruiting
    - Research Site
Chile
- - Concepción, Chile, 4070196
    - Active, not recruiting
    - Research Site
  - La Serena, Chile, 1720430
    - Active, not recruiting
    - Research Site
  - Port Montt, Chile, 5500243
    - Active, not recruiting
    - Research Site
  - Santiago, Chile, 8150215
    - Active, not recruiting
    - Research Site
  - Santiago, Chile, 8330032
    - Active, not recruiting
    - Research Site
  - Santiago, Chile, 8330336
    - Active, not recruiting
    - Research Site
  - Talca, Chile, 3460000
    - Active, not recruiting
    - Research Site
  - Temuco, Chile, 4780000
    - Active, not recruiting
    - Research Site
  - Viña del Mar, Chile, 2520000
    - Active, not recruiting
    - Research Site
China
- - Baoding, China, 071000
    - Active, not recruiting
    - Research Site
  - Beijing, China, 100021
    - Withdrawn
    - Research Site
  - Beijing, China
    - Withdrawn
    - Research Site
  - Beijing, China, 100142
    - Active, not recruiting
    - Research Site
  - Beijing, China, 100044
    - Active, not recruiting
    - Research Site
  - Beijing, China, 100005
    - Active, not recruiting
    - Research Site
  - Changchun, China, 130021
    - Active, not recruiting
    - Research Site
  - Changsha, China, 410008
    - Active, not recruiting
    - Research Site
  - Chengdu, China, 610041
    - Active, not recruiting
    - Research Site
  - Chengdu, China, 610072
    - Active, not recruiting
    - Research Site
  - Chengdu, China, 610000
    - Active, not recruiting
    - Research Site
  - Chifeng, China, 024000
    - Active, not recruiting
    - Research Site
  - Dalian, China, 116023
    - Active, not recruiting
    - Research Site
  - Foshan, China, 528000
    - Active, not recruiting
    - Research Site
  - Fuzhou, China, 350001
    - Withdrawn
    - Research Site
  - Fuzhou, China, 350011
    - Active, not recruiting
    - Research Site
  - Guangzhou, China, 510060
    - Active, not recruiting
    - Research Site
  - Guangzhou, China, 510120
    - Withdrawn
    - Research Site
  - Guangzhou, China, 510168
    - Withdrawn
    - Research Site
  - Haikou, China, 570311
    - Active, not recruiting
    - Research Site
  - Haikou, China, 570102
    - Withdrawn
    - Research Site
  - Hangzhou, China, 310003
    - Active, not recruiting
    - Research Site
  - Hangzhou, China, 310020
    - Active, not recruiting
    - Research Site
  - Hangzhou, China, 310022
    - Active, not recruiting
    - Research Site
  - Hangzhou, China, 310009
    - Active, not recruiting
    - Research Site
  - Harbin, China, 150081
    - Active, not recruiting
    - Research Site
  - Hefei, China, 230001
    - Active, not recruiting
    - Research Site
  - Hefei, China, 230601
    - Active, not recruiting
    - Research Site
  - Hefei, China, 230012
    - Active, not recruiting
    - Research Site
  - Hohhot, China, 010010
    - Active, not recruiting
    - Research Site
  - Huangpu District, China, 200025
    - Withdrawn
    - Research Site
  - Jinan, China, 2501117
    - Active, not recruiting
    - Research Site
  - Lanzhou, China, 730050
    - Active, not recruiting
    - Research Site
  - Liuzhou, China, 545005
    - Active, not recruiting
    - Research Site
  - Nanchang, China, 330009
    - Active, not recruiting
    - Research Site
  - Nanjing, China, 210029
    - Active, not recruiting
    - Research Site
  - Nanjing, China, 210009
    - Active, not recruiting
    - Research Site
  - Nanning, China, 530021
    - Active, not recruiting
    - Research Site
  - Nanning, China, 530021
    - Withdrawn
    - Research Site
  - Neijiang, China, 641000
    - Active, not recruiting
    - Research Site
  - Qingdao, China, 266100
    - Withdrawn
    - Research Site
  - Shanghai, China, 200032
    - Withdrawn
    - Research Site
  - Shanghai, China, 200032
    - Active, not recruiting
    - Research Site
  - Shanghai, China, 200127
    - Active, not recruiting
    - Research Site
  - Shantou, China, 515031
    - Withdrawn
    - Research Site
  - Shaoguan, China, 512027
    - Active, not recruiting
    - Research Site
  - Shenyang, China, 110001
    - Withdrawn
    - Research Site
  - Shenyang, China, 110016
    - Active, not recruiting
    - Research Site
  - Shijiazhuang, China, 050020
    - Active, not recruiting
    - Research Site
  - Suining, China, 629000
    - Active, not recruiting
    - Research Site
  - Suzhou, China, 215006
    - Active, not recruiting
    - Research Site
  - Taiyuan, China, 030000
    - Withdrawn
    - Research Site
  - Taizhou, China, 317000
    - Active, not recruiting
    - Research Site
  - Tianjin, China, 300060
    - Active, not recruiting
    - Research Site
  - Weifang, China, 261000
    - Active, not recruiting
    - Research Site
  - Wuhan, China, 430079
    - Active, not recruiting
    - Research Site
  - Wuhan, China, 430022
    - Active, not recruiting
    - Research Site
  - Wuhan, China, 430070
    - Active, not recruiting
    - Research Site
  - Xiangfan, China, 441021
    - Active, not recruiting
    - Research Site
  - Xining, China, 810001
    - Withdrawn
    - Research Site
  - Xinxiang, China, 453100
    - Active, not recruiting
    - Research Site
  - Xuzhou, China, 221000
    - Active, not recruiting
    - Research Site
  - Xuzhou, China, 221009
    - Active, not recruiting
    - Research Site
  - Yanji, China, 133000
    - Active, not recruiting
    - Research Site
  - Yantai, China, 264000
    - Active, not recruiting
    - Research Site
  - Zhengzhou, China, 450052
    - Active, not recruiting
    - Research Site
Colombia
- - Barranquilla, Colombia, 80020
    - Withdrawn
    - Research Site
  - Barranquilla, Colombia, 080020
    - Withdrawn
    - Research Site
  - Bogotá, Colombia, 110221
    - Withdrawn
    - Research Site
  - Bogotá, Colombia, 111511
    - Withdrawn
    - Research Site
  - Cali, Colombia, 760042
    - Withdrawn
    - Research Site
  - Floridablanca, Colombia, 681004
    - Withdrawn
    - Research Site
  - Medellín, Colombia, 50030
    - Withdrawn
    - Research Site
  - Montería, Colombia, 23001
    - Withdrawn
    - Research Site
  - Pereira, Colombia
    - Withdrawn
    - Research Site
  - Valledupar, Colombia, 200001
    - Withdrawn
    - Research Site
Czechia
- - Hořovice, Czechia, 268 31
    - Active, not recruiting
    - Research Site
  - Pardubice, Czechia, 532 03
    - Active, not recruiting
    - Research Site
  - Prague, Czechia, 140 00
    - Active, not recruiting
    - Research Site
  - Prague, Czechia, 15006
    - Withdrawn
    - Research Site
  - Pragues, Czechia, 18081
    - Withdrawn
    - Research Site
  - Příbram, Czechia, 261 01
    - Withdrawn
    - Research Site
France
- - Angers, France, 49055
    - Withdrawn
    - Research Site
  - Argenteuil, France, 95100
    - Active, not recruiting
    - Research Site
  - Avignon, France, 84918
    - Active, not recruiting
    - Research Site
  - Bordeaux, France, 33000
    - Active, not recruiting
    - Research Site
  - Bordeaux, France, 33077
    - Active, not recruiting
    - Research Site
  - Bourg-en-Bresse, France, 01012
    - Withdrawn
    - Research Site
  - Caen, France, 14076
    - Active, not recruiting
    - Research Site
  - Cholet, France, 49300
    - Active, not recruiting
    - Research Site
  - Clermont-Ferrand, France, 63011
    - Withdrawn
    - Research Site
  - Dijon, France, 21079
    - Withdrawn
    - Research Site
  - Epagny Metz-Tessy, France, 74370
    - Withdrawn
    - Research Site
  - Lille, France, 59000
    - Active, not recruiting
    - Research Site
  - Lorient, France, 56322
    - Active, not recruiting
    - Research Site
  - Lyon, France, 69008
    - Active, not recruiting
    - Research Site
  - Marseille, France, 13273
    - Active, not recruiting
    - Research Site
  - Metz, France, 57085
    - Active, not recruiting
    - Research Site
  - Montpellier, France, 34070
    - Active, not recruiting
    - Research Site
  - Montpellier, France, 34298
    - Active, not recruiting
    - Research Site
  - Nantes, France, 44202
    - Active, not recruiting
    - Research Site
  - Nîmes, France, 30029
    - Active, not recruiting
    - Research Site
  - Paris, France, 75013
    - Active, not recruiting
    - Research Site
  - Paris, France, 75010
    - Withdrawn
    - Research Site
  - Pierre-Bénite, France, 69310
    - Active, not recruiting
    - Research Site
  - Plerin SUR MER, France, 22190
    - Active, not recruiting
    - Research Site
  - Poitiers, France, 86021
    - Active, not recruiting
    - Research Site
  - Quimper, France, 29107
    - Active, not recruiting
    - Research Site
  - Rennes, France, 35042
    - Withdrawn
    - Research Site
  - Saint-Cloud, France, 92210
    - Withdrawn
    - Research Site
  - Saint-Herblain, France, 44805
    - Withdrawn
    - Research Site
  - Saint-Priest-en-Jarez, France, 42270
    - Active, not recruiting
    - Research Site
  - Suresnes, France, 92151
    - Active, not recruiting
    - Research Site
  - Toulouse, France, 31059
    - Active, not recruiting
    - Research Site
  - Tours, France, 37044
    - Active, not recruiting
    - Research Site
  - Villejuif, France, 94805
    - Active, not recruiting
    - Research Site
Georgia
- - Batumi, Georgia, 6400
    - Active, not recruiting
    - Research Site
  - Tbilisi, Georgia, 0179
    - Active, not recruiting
    - Research Site
  - Tbilisi, Georgia, 112
    - Active, not recruiting
    - Research Site
  - Tbilisi, Georgia, 160
    - Withdrawn
    - Research Site
  - Tbilisi, Georgia, 186
    - Withdrawn
    - Research Site
Germany
- - Aachen, Germany, 52074
    - Recruiting
    - Research Site
  - Augsburg, Germany, 86150
    - Recruiting
    - Research Site
  - Bayreuth, Germany, 95445
    - Withdrawn
    - Research Site
  - Berlin, Germany, 10317
    - Recruiting
    - Research Site
  - Berlin, Germany, 12623
    - Recruiting
    - Research Site
  - Bonn, Germany, 53111
    - Recruiting
    - Research Site
  - Deggendorf, Germany, 94469
    - Withdrawn
    - Research Site
  - Dessau, Germany, 6847
    - Recruiting
    - Research Site
  - Dresden, Germany, 01307
    - Recruiting
    - Research Site
  - Düsseldorf, Germany, 40225
    - Recruiting
    - Research Site
  - Düsseldorf, Germany, 40235
    - Recruiting
    - Research Site
  - Eggenfelden, Germany, 84307
    - Recruiting
    - Research Site
  - Esslingen am Neckar, Germany, 73730
    - Recruiting
    - Research Site
  - Georgsmarienhütte, Germany, 49124
    - Recruiting
    - Research Site
  - Gütersloh, Germany, 33332
    - Recruiting
    - Research Site
  - Hamburg, Germany, 20259
    - Recruiting
    - Research Site
  - Hamburg, Germany, 21073
    - Recruiting
    - Research Site
  - Heidelberg, Germany, 69120
    - Recruiting
    - Research Site
  - Kiel, Germany, 24105
    - Withdrawn
    - Research Site
  - Landshut, Germany, 84036
    - Recruiting
    - Research Site
  - Lübeck, Germany, 23562
    - Withdrawn
    - Research Site
  - Mainz, Germany, 55131
    - Withdrawn
    - Research Site
  - Memmingen, Germany, 87700
    - Recruiting
    - Research Site
  - München, Germany, 80637
    - Recruiting
    - Research Site
  - Ravensburg, Germany, 88212
    - Recruiting
    - Research Site
  - Rüsselsheim am Main, Germany, 65428
    - Recruiting
    - Research Site
  - Stralsund, Germany, 18439
    - Recruiting
    - Research Site
  - Torgau, Germany, 4860
    - Recruiting
    - Research Site
  - Trier, Germany, 54290
    - Recruiting
    - Research Site
  - Ulm, Germany, 89075
    - Withdrawn
    - Research Site
  - Velbert, Germany, 42551
    - Withdrawn
    - Research Site
  - Wiesbaden, Germany, 65199
    - Recruiting
    - Research Site
  - Wiesbaden, Germany, 65189
    - Withdrawn
    - Research Site
  - Worms, Germany, 67550
    - Recruiting
    - Research Site
  - Wuppertal, Germany, 42283
    - Recruiting
    - Research Site
Greece
- - Athens, Greece, 11528
    - Active, not recruiting
    - Research Site
  - Athens, Greece, 15123
    - Active, not recruiting
    - Research Site
  - Athens, Greece, 18537
    - Active, not recruiting
    - Research Site
  - Chaïdári, Greece, 124 62
    - Active, not recruiting
    - Research Site
  - Heraklion, Greece, 71110
    - Active, not recruiting
    - Research Site
  - Ioannina, Greece, 45500
    - Active, not recruiting
    - Research Site
  - Rio, Greece, 265 04
    - Active, not recruiting
    - Research Site
  - Thessaloniki, Greece, 54645
    - Active, not recruiting
    - Research Site
  - Thessaloniki, Greece, 546 39
    - Active, not recruiting
    - Research Site
  - Thessaloniki, Greece, 54631
    - Active, not recruiting
    - Research Site
  - Thessaloniki, Greece, 57001
    - Active, not recruiting
    - Research Site
  - Thessaloniki, Greece, 54645
    - Terminated
    - Research Site
Hungary
- - Budapest, Hungary, 1106
    - Withdrawn
    - Research Site
  - Budapest, Hungary, 1083
    - Active, not recruiting
    - Research Site
  - Budapest, Hungary, 1122
    - Active, not recruiting
    - Research Site
  - Budapest, Hungary, 1115
    - Active, not recruiting
    - Research Site
  - Debrecen, Hungary, 4032
    - Active, not recruiting
    - Research Site
  - Gyula, Hungary, 5700
    - Active, not recruiting
    - Research Site
  - Győr, Hungary, 9024
    - Active, not recruiting
    - Research Site
  - Kaposvár, Hungary, 7400
    - Active, not recruiting
    - Research Site
  - Miskolc, Hungary, 3526
    - Active, not recruiting
    - Research Site
  - Nyíregyháza, Hungary, 4400
    - Active, not recruiting
    - Research Site
  - Szekszárd, Hungary, 7100
    - Active, not recruiting
    - Research Site
  - Szolnok, Hungary, 5000
    - Withdrawn
    - Research Site
India
- - Bangalore, India, 560076
    - Withdrawn
    - Research Site
  - Bangalore, India, 560027
    - Terminated
    - Research Site
  - Belagavi, India, 590010
    - Withdrawn
    - Research Site
  - Bhubaneswar, India, 751019
    - Withdrawn
    - Research Site
  - Hubli, India, 580029
    - Active, not recruiting
    - Research Site
  - Hyderabad, India, 500082
    - Withdrawn
    - Research Site
  - Jaipur, India, 302017
    - Withdrawn
    - Research Site
  - Kolkata, India, 700020
    - Active, not recruiting
    - Research Site
  - Mumbai, India, 400 012
    - Active, not recruiting
    - Research Site
  - Nagpur, India, 440026
    - Withdrawn
    - Research Site
  - Nashik, India, 422005
    - Active, not recruiting
    - Research Site
  - New Delhi, India, 110076
    - Withdrawn
    - Research Site
  - New Delhi, India, 110 085
    - Active, not recruiting
    - Research Site
  - New Delhi, India, 110005
    - Withdrawn
    - Research Site
  - Pune, India, 411004
    - Withdrawn
    - Research Site
  - Thane, India, 401107
    - Withdrawn
    - Research Site
  - Visakhapatnam, India, 530040
    - Active, not recruiting
    - Research Site
  - West Bengal, India, 700 156
    - Terminated
    - Research Site
Israel
- - Afula, Israel, 1834111
    - Active, not recruiting
    - Research Site
  - Ashdod, Israel, 7747629
    - Recruiting
    - Research Site
  - Haifa, Israel, 31096
    - Active, not recruiting
    - Research Site
  - Jerusalem, Israel, 9103102
    - Terminated
    - Research Site
  - Jerusalem, Israel, 00000
    - Active, not recruiting
    - Research Site
  - Kfar Saba, Israel, 4428164
    - Active, not recruiting
    - Research Site
  - Nahariya, Israel, 22100
    - Active, not recruiting
    - Research Site
  - Ramat Gan, Israel, 52621
    - Active, not recruiting
    - Research Site
  - Rehovot, Israel, 7661041
    - Active, not recruiting
    - Research Site
  - Tel Aviv, Israel, 69710
    - Withdrawn
    - Research Site
Italy
- - Bari, Italy, 70124
    - Active, not recruiting
    - Research Site
  - Catania, Italy, 95126
    - Active, not recruiting
    - Research Site
  - Catanzaro, Italy, 88100
    - Active, not recruiting
    - Research Site
  - Florence, Italy, 50134
    - Active, not recruiting
    - Research Site
  - Genova, Italy, 16132
    - Active, not recruiting
    - Research Site
  - Grosseto, Italy, 58100
    - Active, not recruiting
    - Research Site
  - Milan, Italy, 20141
    - Active, not recruiting
    - Research Site
  - Milan, Italy, 20132
    - Active, not recruiting
    - Research Site
  - Modena, Italy, 41125
    - Active, not recruiting
    - Research Site
  - Naples, Italy, 80131
    - Active, not recruiting
    - Research Site
  - Naples, Italy, 80131
    - Withdrawn
    - Research Site
  - Pisa, Italy, 56126
    - Active, not recruiting
    - Research Site
  - Reggio Emilia, Italy, 42122
    - Active, not recruiting
    - Research Site
  - Roma, Italy, 00168
    - Active, not recruiting
    - Research Site
  - Rozzano, Italy, 20089
    - Active, not recruiting
    - Research Site
  - Turin, Italy, 10128
    - Active, not recruiting
    - Research Site
Japan
- - Chiba, Japan, 260-8717
    - Active, not recruiting
    - Research Site
  - Chūōku, Japan, 104-8560
    - Active, not recruiting
    - Research Site
  - Fukuoka, Japan, 811-1395
    - Active, not recruiting
    - Research Site
  - Fukushima, Japan, 960-1295
    - Active, not recruiting
    - Research Site
  - Hidaka-shi, Japan, 350-1298
    - Active, not recruiting
    - Research Site
  - Hirakata-shi, Japan, 573-1191
    - Active, not recruiting
    - Research Site
  - Hiroshima, Japan, 730-0011
    - Active, not recruiting
    - Research Site
  - Isehara-shi, Japan, 259-1193
    - Active, not recruiting
    - Research Site
  - Kagoshima, Japan, 892-0833
    - Active, not recruiting
    - Research Site
  - Kashiwa, Japan, 227-8577
    - Active, not recruiting
    - Research Site
  - Kitaadachi-gun, Japan, 362-0806
    - Active, not recruiting
    - Research Site
  - Kumamoto, Japan, 860-8556
    - Active, not recruiting
    - Research Site
  - Kurume-shi, Japan, 830-0013
    - Active, not recruiting
    - Research Site
  - Kyoto, Japan, 606-8507
    - Active, not recruiting
    - Research Site
  - Kōtoku, Japan, 135-8550
    - Active, not recruiting
    - Research Site
  - Matsuyama, Japan, 791-0280
    - Active, not recruiting
    - Research Site
  - Nagoya, Japan, 464-8681
    - Active, not recruiting
    - Research Site
  - Nagoya, Japan, 466-8560
    - Active, not recruiting
    - Research Site
  - Nagoya, Japan, 467-0001
    - Active, not recruiting
    - Research Site
  - Niigata, Japan, 951-8566
    - Active, not recruiting
    - Research Site
  - Osaka, Japan, 533-0024
    - Active, not recruiting
    - Research Site
  - Osaka, Japan, 541-8567
    - Active, not recruiting
    - Research Site
  - Osaka, Japan, 540-0006
    - Active, not recruiting
    - Research Site
  - Ota-shi, Japan, 373-8550
    - Active, not recruiting
    - Research Site
  - Sagamihara-shi, Japan, 252-0375
    - Active, not recruiting
    - Research Site
  - Sapporo, Japan, 060-8648
    - Active, not recruiting
    - Research Site
  - Sendai, Japan, 980-8574
    - Active, not recruiting
    - Research Site
  - Shinagawa-ku, Japan, 142-8666
    - Active, not recruiting
    - Research Site
  - Suita-shi, Japan, 565-0871
    - Active, not recruiting
    - Research Site
  - Sunto-gun, Japan, 411-8777
    - Active, not recruiting
    - Research Site
  - Takasaki-shi, Japan, 370-0829
    - Active, not recruiting
    - Research Site
  - Tsu, Japan, 514-8507
    - Active, not recruiting
    - Research Site
  - Yokohama, Japan, 241-8515
    - Active, not recruiting
    - Research Site
  - Ōita, Japan, 870-8511
    - Active, not recruiting
    - Research Site
Malaysia
- - George Town, Malaysia, 10450
    - Active, not recruiting
    - Research Site
  - George Town, Malaysia, 10350
    - Active, not recruiting
    - Research Site
  - Johor Bahru, Malaysia, 81100
    - Active, not recruiting
    - Research Site
  - Kota Bharu, Malaysia, 16150
    - Terminated
    - Research Site
  - Kuala Lumpur, Malaysia, 50300
    - Active, not recruiting
    - Research Site
  - Kuala Lumpur, Malaysia, 50450
    - Active, not recruiting
    - Research Site
  - Kuala Lumpur, Malaysia, 50603
    - Active, not recruiting
    - Research Site
  - Kuching, Malaysia, 93586
    - Active, not recruiting
    - Research Site
  - Malacca, Malaysia, 75000
    - Active, not recruiting
    - Research Site
  - Sabak Bernam, Malaysia, 88996
    - Active, not recruiting
    - Research Site
Mexico
- - Aguascalientes, Mexico, 20230
    - Active, not recruiting
    - Research Site
  - Alc. Cuauhtémoc, Mexico, 06100
    - Active, not recruiting
    - Research Site
  - Colonia Lindavista, Mexico, 7300
    - Withdrawn
    - Research Site
  - Mexico City, Mexico, 03310
    - Active, not recruiting
    - Research Site
  - Monterrey, Mexico, 64460
    - Withdrawn
    - Research Site
  - Monterrey, Mexico, 64570
    - Withdrawn
    - Research Site
  - Monterrey, Mexico, 64460
    - Active, not recruiting
    - Research Site
  - Mérida, Mexico, 97300
    - Active, not recruiting
    - Research Site
  - México, Mexico, 14080
    - Withdrawn
    - Research Site
  - México, Mexico, 14080
    - Active, not recruiting
    - Research Site
  - México, Mexico, 6700
    - Active, not recruiting
    - Research Site
  - San Luis Potosí City, Mexico, 78250
    - Withdrawn
    - Research Site
  - Toluca, Mexico, 50180
    - Active, not recruiting
    - Research Site
  - Veracruz, Mexico, 91910
    - Active, not recruiting
    - Research Site
  - Veracruz, Mexico, 91900
    - Active, not recruiting
    - Research Site
Netherlands
- - Dirksland, Netherlands, 3247 BW
    - Active, not recruiting
    - Research Site
  - Geleen, Netherlands, 6162 BG
    - Active, not recruiting
    - Research Site
  - Groningen, Netherlands, 9728 NT
    - Withdrawn
    - Research Site
  - Hoofddorp, Netherlands, 2134 TM
    - Withdrawn
    - Research Site
  - Rotterdam, Netherlands, 3079 DZ
    - Withdrawn
    - Research Site
  - Rotterdam, Netherlands, 3083 AN
    - Active, not recruiting
    - Research Site
Peru
- - Arequipa, Peru, AREQUIPA01
    - Active, not recruiting
    - Research Site
  - Arequipa, Peru, 04001
    - Withdrawn
    - Research Site
  - Arequipa, Peru, 4001
    - Active, not recruiting
    - Research Site
  - Callao, Peru, 7021
    - Withdrawn
    - Research Site
  - La Libertad, Peru, 13013
    - Withdrawn
    - Research Site
  - Lima, Peru, Lima 32
    - Terminated
    - Research Site
  - Lima, Peru, 0051
    - Withdrawn
    - Research Site
  - Lima, Peru, Lima 34
    - Withdrawn
    - Research Site
  - Lima, Peru, 15076
    - Active, not recruiting
    - Research Site
  - Trujillo, Peru
    - Active, not recruiting
    - Research Site
Philippines
- - Bacolod, Philippines, 6100
    - Active, not recruiting
    - Research Site
  - Cebu, Philippines, 6000
    - Active, not recruiting
    - Research Site
  - Iloilo City, Philippines, 5000
    - Withdrawn
    - Research Site
  - Manila, Philippines, 1000
    - Withdrawn
    - Research Site
  - Quezon City, Philippines, 1112
    - Active, not recruiting
    - Research Site
  - Quezon City, Philippines, 0870
    - Withdrawn
    - Research Site
  - Quezon City, Philippines, 1101
    - Terminated
    - Research Site
Poland
- - Bialystok, Poland, 15-027
    - Active, not recruiting
    - Research Site
  - Grudziądz, Poland, 86-300
    - Active, not recruiting
    - Research Site
  - Koszalin, Poland, 75-581
    - Active, not recruiting
    - Research Site
  - Lodz, Poland, 90-302
    - Active, not recruiting
    - Research Site
  - Lublin, Poland, 20-718
    - Active, not recruiting
    - Research Site
  - Opole, Poland, 45-061
    - Active, not recruiting
    - Research Site
  - Poznan, Poland, 61-485
    - Active, not recruiting
    - Research Site
  - Racibórz, Poland, 47-400
    - Active, not recruiting
    - Research Site
  - Rzeszów, Poland, 35-021
    - Active, not recruiting
    - Research Site
  - Warsaw, Poland, 02-781
    - Active, not recruiting
    - Research Site
  - Wieliszew, Poland, 05-135
    - Active, not recruiting
    - Research Site
Portugal
- - Amadora, Portugal, 2720-276
    - Active, not recruiting
    - Research Site
  - Braga, Portugal, 4710-243
    - Active, not recruiting
    - Research Site
  - Guimarães, Portugal, 4835-044
    - Active, not recruiting
    - Research Site
  - Lisbon, Portugal, 1649-035
    - Active, not recruiting
    - Research Site
  - Lisbon, Portugal, 1998-018
    - Active, not recruiting
    - Research Site
  - Matosinhos Municipality, Portugal, 4454-509
    - Active, not recruiting
    - Research Site
  - Porto, Portugal, 4100-180
    - Active, not recruiting
    - Research Site
  - Porto, Portugal, 4200-072
    - Active, not recruiting
    - Research Site
  - Porto, Portugal, 4200-319
    - Active, not recruiting
    - Research Site
  - Vila Nova de Gaia, Portugal, 4434-502
    - Active, not recruiting
    - Research Site
Romania
- - Baia Mare, Romania, 430031
    - Withdrawn
    - Research Site
  - Brasov, Romania, 500283
    - Active, not recruiting
    - Research Site
  - Cluj-Napoca, Romania, 400641
    - Active, not recruiting
    - Research Site
  - Cluj-Napoca, Romania, 400015
    - Terminated
    - Research Site
  - Constanța, Romania, 900591
    - Terminated
    - Research Site
  - Craiova, Romania, 200094
    - Active, not recruiting
    - Research Site
  - Craiova, Romania, 200347
    - Active, not recruiting
    - Research Site
  - Craiova, Romania, 200385
    - Active, not recruiting
    - Research Site
  - Floreşti, Romania, 407280
    - Active, not recruiting
    - Research Site
  - Iași, Romania, 700106
    - Active, not recruiting
    - Research Site
  - Oradea, Romania, 410167
    - Withdrawn
    - Research Site
  - Piteşti, Romania, 110283
    - Active, not recruiting
    - Research Site
  - Sibiu, Romania, 550245
    - Active, not recruiting
    - Research Site
  - Timișoara, Romania, 300239
    - Active, not recruiting
    - Research Site
  - Timișoara, Romania, 300166
    - Withdrawn
    - Research Site
Serbia
- - Belgrade, Serbia, 11000
    - Active, not recruiting
    - Research Site
  - Belgrade, Serbia, 11080
    - Active, not recruiting
    - Research Site
  - Belgrade, Serbia, 11010
    - Active, not recruiting
    - Research Site
  - Kamenitz, Serbia, 21204
    - Active, not recruiting
    - Research Site
  - Kragujevac, Serbia, 34000
    - Active, not recruiting
    - Research Site
  - Niš, Serbia, 18000
    - Active, not recruiting
    - Research Site
  - Valjevo, Serbia, 14000
    - Active, not recruiting
    - Research Site
  - Zrenjanin, Serbia, 23000
    - Active, not recruiting
    - Research Site
Singapore
- - Singapore, Singapore, 329563
    - Active, not recruiting
    - Research Site
  - Singapore, Singapore, 119074
    - Active, not recruiting
    - Research Site
  - Singapore, Singapore, 308433
    - Active, not recruiting
    - Research Site
  - Singapore, Singapore, 228510
    - Active, not recruiting
    - Research Site
South Africa
- - Bloemfontein, South Africa, 9301
    - Withdrawn
    - Research Site
  - Bloemfontein, South Africa, 9301
    - Active, not recruiting
    - Research Site
  - George, South Africa, 6529
    - Active, not recruiting
    - Research Site
  - George, South Africa, 6529
    - Withdrawn
    - Research Site
  - Johannesburg, South Africa, 2193
    - Recruiting
    - Research Site
  - Johannesburg, South Africa, 2196
    - Terminated
    - Research Site
  - Pietermaritzburg, South Africa, 3201
    - Withdrawn
    - Research Site
  - Pretoria, South Africa, 0084
    - Withdrawn
    - Research Site
  - Pretoria, South Africa, 31
    - Active, not recruiting
    - Research Site
  - Soweto, South Africa, 2193
    - Active, not recruiting
    - Research Site
  - eManzimtoti, South Africa, 4126
    - Terminated
    - Research Site
South Korea
- - Busan, South Korea, 48108
    - Active, not recruiting
    - Research Site
  - Daegu, South Korea, 42601
    - Active, not recruiting
    - Research Site
  - Donggu, South Korea, 44033
    - Withdrawn
    - Research Site
  - Goyang-si, South Korea, 10408
    - Active, not recruiting
    - Research Site
  - Jeonnam, South Korea, 58128
    - Active, not recruiting
    - Research Site
  - Seongbuk-Gu, South Korea, 2841
    - Withdrawn
    - Research Site
  - Seoul, South Korea, 03080
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 03722
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 06273
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 06351
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 06591
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 158-710
    - Active, not recruiting
    - Research Site
  - Seoul, South Korea, 08308
    - Terminated
    - Research Site
Spain
- - A Coruña, Spain, 15009
    - Active, not recruiting
    - Research Site
  - A Coruña, Spain, 15006
    - Active, not recruiting
    - Research Site
  - Albacete, Spain, 02006
    - Active, not recruiting
    - Research Site
  - Alcoy, Spain, 3804
    - Active, not recruiting
    - Research Site
  - Alicante, Spain, 3015
    - Active, not recruiting
    - Research Site
  - Alzira, Spain, 46600
    - Active, not recruiting
    - Research Site
  - Badajoz, Spain, 06080
    - Active, not recruiting
    - Research Site
  - Badalona, Spain, 08916
    - Active, not recruiting
    - Research Site
  - Badalona, Spain, 08003
    - Recruiting
    - Research Site
  - Barakaldo, Spain, 48903
    - Active, not recruiting
    - Research Site
  - Barcelona, Spain, 8035
    - Recruiting
    - Research Site
  - Barcelona, Spain, 08036
    - Active, not recruiting
    - Research Site
  - Barcelona, Spain, 08028
    - Active, not recruiting
    - Research Site
  - Cáceres, Spain, 10003
    - Active, not recruiting
    - Research Site
  - Elche(Alicante), Spain, 03202
    - Active, not recruiting
    - Research Site
  - Galdakao, Spain, 48960
    - Active, not recruiting
    - Research Site
  - Girona, Spain, 17007
    - Active, not recruiting
    - Research Site
  - Granada, Spain, 18014
    - Active, not recruiting
    - Research Site
  - Granada, Spain, 18007
    - Active, not recruiting
    - Research Site
  - Jerez de La Frontera (Cádiz), Spain, 11407
    - Active, not recruiting
    - Research Site
  - L'Hospitalet de Llobregat, Spain, 08908
    - Active, not recruiting
    - Research Site
  - Leganés, Spain, 28911
    - Active, not recruiting
    - Research Site
  - Lleida, Spain, 25198
    - Active, not recruiting
    - Research Site
  - Madrid, Spain, 28040
    - Recruiting
    - Research Site
  - Madrid, Spain, 28040
    - Active, not recruiting
    - Research Site
  - Madrid, Spain, 28033
    - Active, not recruiting
    - Research Site
  - Madrid, Spain, 28050
    - Active, not recruiting
    - Research Site
  - Majadahonda, Spain, 28222
    - Active, not recruiting
    - Research Site
  - Manresa, Spain, 8242
    - Active, not recruiting
    - Research Site
  - Murcia, Spain, 30008
    - Active, not recruiting
    - Research Site
  - Oviedo, Spain, 33011
    - Active, not recruiting
    - Research Site
  - Parla, Spain, 28981
    - Active, not recruiting
    - Research Site
  - Port de Sagunt, Spain, 46520
    - Active, not recruiting
    - Research Site
  - Reus, Spain, 43204
    - Active, not recruiting
    - Research Site
  - Salamanca, Spain, 37007
    - Active, not recruiting
    - Research Site
  - San Sebastián, Spain, 20014
    - Active, not recruiting
    - Research Site
  - Sant Joan d'Alacant, Spain, 03550
    - Withdrawn
    - Research Site
  - Santander, Spain, 39008
    - Active, not recruiting
    - Research Site
  - Seville, Spain, 41009
    - Active, not recruiting
    - Research Site
  - Seville, Spain, 41013
    - Active, not recruiting
    - Research Site
  - Teruel, Spain, 44001
    - Terminated
    - Research Site
  - Toledo, Spain, 45007
    - Withdrawn
    - Research Site
  - Valencia, Spain, 46009
    - Active, not recruiting
    - Research Site
  - Valencia, Spain, 46017
    - Active, not recruiting
    - Research Site
  - Valencia, Spain, 46015
    - Active, not recruiting
    - Research Site
Taiwan
- - Hsinchu, Taiwan, 300
    - Active, not recruiting
    - Research Site
  - Kaohsiung City, Taiwan, 82445
    - Active, not recruiting
    - Research Site
  - Taichung, Taiwan, 40447
    - Withdrawn
    - Research Site
  - Tainan, Taiwan, 710
    - Active, not recruiting
    - Research Site
  - Tainan, Taiwan, 70403
    - Active, not recruiting
    - Research Site
  - Taipei, Taiwan, 10002
    - Active, not recruiting
    - Research Site
  - Taipei, Taiwan, 11259
    - Active, not recruiting
    - Research Site
  - Taipei, Taiwan, 110
    - Active, not recruiting
    - Research Site
Thailand
- - Bangkok, Thailand, 10400
    - Active, not recruiting
    - Research Site
  - Bangkok, Thailand, 10700
    - Active, not recruiting
    - Research Site
  - Khon Kaen, Thailand, 40002
    - Active, not recruiting
    - Research Site
  - Phisanulok, Thailand, 65000
    - Active, not recruiting
    - Research Site
  - Phitsanulok, Thailand, 65000
    - Active, not recruiting
    - Research Site
  - Rachathewi, Thailand, 10400
    - Active, not recruiting
    - Research Site
  - Songkhla, Thailand, 90110
    - Active, not recruiting
    - Research Site
Turkey (Türkiye)
- - Ankara, Turkey (Türkiye), 06100
    - Active, not recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06200
    - Active, not recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06520
    - Active, not recruiting
    - Research Site
  - Ankara, Turkey (Türkiye), 06620
    - Withdrawn
    - Research Site
  - Ankara, Turkey (Türkiye), 6800
    - Withdrawn
    - Research Site
  - Aydin, Turkey (Türkiye), 9010
    - Active, not recruiting
    - Research Site
  - Bursa, Turkey (Türkiye), 16059
    - Withdrawn
    - Research Site
  - Dinar, Turkey (Türkiye), 03400
    - Active, not recruiting
    - Research Site
  - Istanbul, Turkey (Türkiye), 34010
    - Withdrawn
    - Research Site
  - Istanbul, Turkey (Türkiye), 34218
    - Withdrawn
    - Research Site
  - Istanbul, Turkey (Türkiye), 34899
    - Active, not recruiting
    - Research Site
  - Izmir, Turkey (Türkiye), 35120
    - Withdrawn
    - Research Site
  - Izmir, Turkey (Türkiye), 35150
    - Active, not recruiting
    - Research Site
  - Izmir, Turkey (Türkiye), 35530
    - Active, not recruiting
    - Research Site
  - Izmir, Turkey (Türkiye), 35575
    - Active, not recruiting
    - Research Site
  - Samsun, Turkey (Türkiye), 55200
    - Active, not recruiting
    - Research Site
United Kingdom
- - Brighton, United Kingdom, BN2 5BE
    - Active, not recruiting
    - Research Site
  - Burton-on-Trent, United Kingdom, DE13 0RB
    - Active, not recruiting
    - Research Site
  - Cambridge, United Kingdom, CB2 0QQ
    - Active, not recruiting
    - Research Site
  - Derby, United Kingdom, DE22 3NE
    - Active, not recruiting
    - Research Site
  - Edinburgh, United Kingdom, EH4 2XU
    - Active, not recruiting
    - Research Site
  - Guildford, United Kingdom
    - Withdrawn
    - Research Site
  - Ipswich, United Kingdom, IP4 5PD
    - Active, not recruiting
    - Research Site
  - Keighley, United Kingdom, BD20 6TD
    - Withdrawn
    - Research Site
  - London, United Kingdom, SW3 6JJ
    - Active, not recruiting
    - Research Site
  - London, United Kingdom, SE1 9RT
    - Terminated
    - Research Site
  - Manchester, United Kingdom, M20 4BX
    - Active, not recruiting
    - Research Site
  - Oxford, United Kingdom, OX3 7LJ
    - Active, not recruiting
    - Research Site
  - Peterborough, United Kingdom, PE3 9GZ
    - Withdrawn
    - Research Site
  - Stoke-on-Trent, United Kingdom, ST4 6QG
    - Withdrawn
    - Research Site
  - Sutton, United Kingdom, SM2 5PT
    - Active, not recruiting
    - Research Site
United States
- Alabama
  - Birmingham, Alabama, United States, 35205
    - Active, not recruiting
    - Research Site
  - Dothan, Alabama, United States, 36303
    - Active, not recruiting
    - Research Site
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Active, not recruiting
    - Research Site
- Arizona
  - Chandler, Arizona, United States, 85224
    - Active, not recruiting
    - Research Site
- Arkansas
  - Hot Springs, Arkansas, United States, 71913
    - Active, not recruiting
    - Research Site
- California
  - Anaheim, California, United States, 92801
    - Active, not recruiting
    - Research Site
  - Beverly Hills, California, United States, 90211
    - Active, not recruiting
    - Research Site
  - Concord, California, United States, 94520
    - Active, not recruiting
    - Research Site
  - Corona, California, United States, 92882
    - Active, not recruiting
    - Research Site
  - Fountain Valley, California, United States, 92708
    - Active, not recruiting
    - Research Site
  - Greenbrae, California, United States, 94904
    - Active, not recruiting
    - Research Site
  - Los Alamitos, California, United States, 90720
    - Active, not recruiting
    - Research Site
  - Palo Alto, California, United States, 94304
    - Active, not recruiting
    - Research Site
  - San Diego, California, United States, 92123
    - Active, not recruiting
    - Research Site
  - San Diego, California, United States, 92121
    - Active, not recruiting
    - Research Site
  - Whittier, California, United States, 90603
    - Active, not recruiting
    - Research Site
- Colorado
  - Aurora, Colorado, United States, 80045
    - Withdrawn
    - Research Site
- Connecticut
  - Hartford, Connecticut, United States, 06102
    - Active, not recruiting
    - Research Site
- Florida
  - Fort Myers, Florida, United States, 33901
    - Active, not recruiting
    - Research Site
  - Gainesville, Florida, United States, 32603
    - Active, not recruiting
    - Research Site
  - Miami Beach, Florida, United States, 33140
    - Active, not recruiting
    - Research Site
  - Orlando, Florida, United States, 32806
    - Active, not recruiting
    - Research Site
  - Plantation, Florida, United States, 33324
    - Active, not recruiting
    - Research Site
  - Port Saint Lucie, Florida, United States, 34952
    - Active, not recruiting
    - Research Site
  - Saint Augustine, Florida, United States, 32086
    - Active, not recruiting
    - Research Site
  - St. Petersburg, Florida, United States, 33705
    - Active, not recruiting
    - Research Site
  - St. Petersburg, Florida, United States, 33709
    - Active, not recruiting
    - Research Site
  - Tallahassee, Florida, United States, 32308
    - Active, not recruiting
    - Research Site
  - West Palm Beach, Florida, United States, 33401
    - Active, not recruiting
    - Research Site
  - Winter Haven, Florida, United States, 33880
    - Active, not recruiting
    - Research Site
- Georgia
  - Atlanta, Georgia, United States, 30310
    - Active, not recruiting
    - Research Site
  - Atlanta, Georgia, United States, 30318
    - Active, not recruiting
    - Research Site
  - Columbus, Georgia, United States, 31904
    - Active, not recruiting
    - Research Site
- Hawaii
  - Honolulu, Hawaii, United States, 96813
    - Withdrawn
    - Research Site
- Illinois
  - Chicago, Illinois, United States, 60637
    - Active, not recruiting
    - Research Site
  - Chicago, Illinois, United States, 60608
    - Withdrawn
    - Research Site
  - Decatur, Illinois, United States, 62526
    - Active, not recruiting
    - Research Site
  - Elmhurst, Illinois, United States, 60126
    - Active, not recruiting
    - Research Site
  - Hinsdale, Illinois, United States, 60521
    - Active, not recruiting
    - Research Site
  - Park Ridge, Illinois, United States, 60068
    - Active, not recruiting
    - Research Site
  - Park Ridge, Illinois, United States, 60068
    - Terminated
    - Research Site
- Indiana
  - Fort Wayne, Indiana, United States, 46804
    - Active, not recruiting
    - Research Site
- Iowa
  - Iowa City, Iowa, United States, 52242
    - Recruiting
    - Research Site
  - Iowa City, Iowa, United States, 52242
    - Active, not recruiting
    - Research Site
- Kentucky
  - Fort Mitchell, Kentucky, United States, 41017
    - Active, not recruiting
    - Research Site
  - Lexington, Kentucky, United States, 40536
    - Active, not recruiting
    - Research Site
  - Louisville, Kentucky, United States, 40202
    - Active, not recruiting
    - Research Site
- Louisiana
  - Baton Rouge, Louisiana, United States, 70809
    - Active, not recruiting
    - Research Site
- Maine
  - Brewer, Maine, United States, 04412
    - Withdrawn
    - Research Site
  - Scarborough, Maine, United States, 04074
    - Withdrawn
    - Research Site
- Maryland
  - Frederick, Maryland, United States, 21702
    - Active, not recruiting
    - Research Site
  - Glenn Dale, Maryland, United States, 20769
    - Active, not recruiting
    - Research Site
  - Silver Spring, Maryland, United States, 20910
    - Active, not recruiting
    - Research Site
  - Towson, Maryland, United States, 21204
    - Active, not recruiting
    - Research Site
- Massachusetts
  - Boston, Massachusetts, United States, 02111
    - Withdrawn
    - Research Site
  - Hyannis, Massachusetts, United States, 02601
    - Active, not recruiting
    - Research Site
- Michigan
  - Ann Arbor, Michigan, United States, 48109
    - Active, not recruiting
    - Research Site
  - Detroit, Michigan, United States, 48202
    - Active, not recruiting
    - Research Site
  - East Lansing, Michigan, United States, 48824
    - Active, not recruiting
    - Research Site
  - Lansing, Michigan, United States, 48910
    - Active, not recruiting
    - Research Site
  - Royal Oak, Michigan, United States, 48073
    - Active, not recruiting
    - Research Site
- Missouri
  - Independence, Missouri, United States, 64057
    - Active, not recruiting
    - Research Site
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Active, not recruiting
    - Research Site
- Nevada
  - Las Vegas, Nevada, United States, 89148
    - Terminated
    - Research Site
- New Hampshire
  - Laconia, New Hampshire, United States, 03246
    - Active, not recruiting
    - Research Site
- New Jersey
  - Belleville, New Jersey, United States, 07109
    - Active, not recruiting
    - Research Site
- New Mexico
  - Farmington, New Mexico, United States, 87401
    - Active, not recruiting
    - Research Site
  - Santa Fe, New Mexico, United States, 87505
    - Active, not recruiting
    - Research Site
- New York
  - East Syracuse, New York, United States, 13057
    - Active, not recruiting
    - Research Site
  - New Hyde Park, New York, United States, 11042
    - Withdrawn
    - Research Site
  - New York, New York, United States, 10011
    - Active, not recruiting
    - Research Site
  - New York, New York, United States, 10029
    - Active, not recruiting
    - Research Site
  - New York, New York, United States, 10019
    - Withdrawn
    - Research Site
  - Stony Brook, New York, United States, 11794
    - Active, not recruiting
    - Research Site
  - The Bronx, New York, United States, 10461
    - Active, not recruiting
    - Research Site
  - White Plains, New York, United States, 10601
    - Active, not recruiting
    - Research Site
- North Carolina
  - Charlotte, North Carolina, United States, 28204
    - Active, not recruiting
    - Research Site
  - Durham, North Carolina, United States, 27710-0001
    - Active, not recruiting
    - Research Site
  - Greensboro, North Carolina, United States, 27403
    - Withdrawn
    - Research Site
  - Raleigh, North Carolina, United States, 27607
    - Active, not recruiting
    - Research Site
  - Rocky Mount, North Carolina, United States, 27804
    - Active, not recruiting
    - Research Site
  - Winston-Salem, North Carolina, United States, 27103
    - Recruiting
    - Research Site
  - Winston-Salem, North Carolina, United States, 27104
    - Recruiting
    - Research Site
- Ohio
  - Cincinnati, Ohio, United States, 45219
    - Withdrawn
    - Research Site
  - Cincinnati, Ohio, United States, 45255
    - Active, not recruiting
    - Research Site
  - Cleveland, Ohio, United States, 44195
    - Active, not recruiting
    - Research Site
  - Cleveland, Ohio, United States, 44106
    - Active, not recruiting
    - Research Site
  - Youngstown, Ohio, United States, 44504
    - Withdrawn
    - Research Site
- Pennsylvania
  - Clairton, Pennsylvania, United States, 15025
    - Active, not recruiting
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19111
    - Active, not recruiting
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19106
    - Active, not recruiting
    - Research Site
  - Pittsburgh, Pennsylvania, United States, 15213
    - Recruiting
    - Research Site
  - Pittsburgh, Pennsylvania, United States, 15213
    - Active, not recruiting
    - Research Site
  - Reading, Pennsylvania, United States, 19611
    - Active, not recruiting
    - Research Site
  - State College, Pennsylvania, United States, 16803
    - Terminated
    - Research Site
- Rhode Island
  - Providence, Rhode Island, United States, 02903
    - Active, not recruiting
    - Research Site
- South Carolina
  - Lancaster, South Carolina, United States, 29720
    - Withdrawn
    - Research Site
  - Spartanburg, South Carolina, United States, 29303
    - Active, not recruiting
    - Research Site
- South Dakota
  - Aberdeen, South Dakota, United States, 57401
    - Recruiting
    - Research Site
  - Mitchell, South Dakota, United States, 57301
    - Active, not recruiting
    - Research Site
  - Pierre, South Dakota, United States, 57501
    - Recruiting
    - Research Site
  - Sioux Falls, South Dakota, United States, 57105
    - Active, not recruiting
    - Research Site
  - Yankton, South Dakota, United States, 57078
    - Active, not recruiting
    - Research Site
- Tennessee
  - Chattanooga, Tennessee, United States, 37404
    - Active, not recruiting
    - Research Site
  - Knoxville, Tennessee, United States, 37920
    - Active, not recruiting
    - Research Site
  - Nashville, Tennessee, United States, 37203
    - Active, not recruiting
    - Research Site
  - Nashville, Tennessee, United States, 37204
    - Active, not recruiting
    - Research Site
- Texas
  - Austin, Texas, United States, 78731
    - Withdrawn
    - Research Site
  - Dallas, Texas, United States, 75230
    - Active, not recruiting
    - Research Site
  - Denton, Texas, United States, 76201
    - Active, not recruiting
    - Research Site
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Research Site
  - Houston, Texas, United States, 77024
    - Active, not recruiting
    - Research Site
  - Irving, Texas, United States, 75063
    - Recruiting
    - Research Site
- Utah
  - Ogden, Utah, United States, 84405
    - Active, not recruiting
    - Research Site
  - Salt Lake City, Utah, United States, 84106
    - Active, not recruiting
    - Research Site
- Virginia
  - Fairfax, Virginia, United States, 22031
    - Active, not recruiting
    - Research Site
  - Lynchburg, Virginia, United States, 24501
    - Active, not recruiting
    - Research Site
  - Midlothian, Virginia, United States, 23114
    - Active, not recruiting
    - Research Site
  - Reston, Virginia, United States, 20190
    - Active, not recruiting
    - Research Site
  - Richmond, Virginia, United States, 23235
    - Active, not recruiting
    - Research Site
- Washington
  - Seattle, Washington, United States, 98104
    - Active, not recruiting
    - Research Site
  - Seattle, Washington, United States, 98101
    - Active, not recruiting
    - Research Site
  - Spokane, Washington, United States, 99202
    - Active, not recruiting
    - Research Site
  - Tacoma, Washington, United States, 98405
    - Active, not recruiting
    - Research Site
- West Virginia
  - Charleston, West Virginia, United States, 25304
    - Withdrawn
    - Research Site
  - Morgantown, West Virginia, United States, 26505
    - Active, not recruiting
    - Research Site
- Wisconsin
  - Appleton, Wisconsin, United States, 54911
    - Withdrawn
    - Research Site
  - Madison, Wisconsin, United States, 53792
    - Active, not recruiting
    - Research Site
  - Milwaukee, Wisconsin, United States, 53226
    - Active, not recruiting
    - Research Site
Vietnam
- - Hanoi, Vietnam, 100000
    - Active, not recruiting
    - Research Site
  - Ho Chi Minh City, Vietnam, 700000
    - Active, not recruiting
    - Research Site
  - Ho Chi Minh City, Vietnam, 70000
    - Active, not recruiting
    - Research Site
  - Huế, Vietnam, 530000
    - Withdrawn
    - Research Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Women and Men, ≥18 years at the time of screening (or per national guidelines)
Histologically confirmed ER+/HER2- early-stage resected invasive breast cancer with high or intermediate risk of recurrence, based on clinical-pathological risk features, as defined in the protocol.
Completed adequate (definitive) locoregional therapy (surgery with or without radiotherapy) for the primary breast tumour(s), with or without (neo)adjuvant chemotherapy
Completed at least 2 years but no more than 5 years (+3 months) of adjuvant ET (+/- CDK4/6 inhibitor)
Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1
Adequate organ and marrow function

Exclusion criteria:

Inoperable locally advanced or metastatic breast cancer
Pathological complete response following treatment with neoadjuvant therapy
History of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix or considered at very low risk of recurrence per investigator judgement) unless in complete remission with no therapy for a minimum of 5 years from the date of randomisation
Any evidence of severe or uncontrolled systemic diseases which, in the investigator's opinion precludes participation in the study or compliance
Known LVEF <50% with heart failure NYHA Grade ≥2.
Mean resting QTcF interval >480 ms at screening
Concurrent exogenous sex hormone therapy
Any concurrent anti-cancer treatment not specified in the protocol with the exception of bisphosphonates (e.g. zoledronic acid) or RANKL inhibitors (eg, denosumab)
Previous treatment with camizestrant, investigational SERDs/investigational ER targeting agents, or fulvestrant
Currently pregnant (confirmed with positive serum pregnancy test) or breastfeeding
Patients with known hypersensitivity to active or inactive excipients of camizestrant or drugs with a similar chemical structure or class to camizestrant. In pre-/peri-menopausal female and male patients, known hypersensitivity or intolerance to LHRH agonists, that would preclude the patient from receiving any LHRH agonist

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Arm A: standard endocrine therapy of investigator´s choice Continue standard endocrine therapy of investigator's choice (aromatase inhibitors [AI; exemestane, letrozole, anastrozole] or tamoxifen)	Drug: Tamoxifen Tamoxifen. Comparator. Administered per local approved label Drug: Anastrozole Anastrozole. Comparator. Administered per local approved label Drug: Letrozole Letrozole. Comparator. Administered per local approved label Drug: Exemestane Exemestane. Comparator. Administered per local approved label
Experimental: Arm B: camizestrant Camizestrant	Drug: Camizestrant Camizestrant. Experimental. Administered orally Other Names: AZD9833

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Invasive breast cancer-free survival (IBCFS) Time Frame: Up to 10 years	IBCFS is defined as time from randomisation until date of first occurrence of: Invasive ipsilateral breast tumour recurrence (invasive IBTR) Locoregional invasive breast cancer recurrence Distant recurrence Invasive contralateral breast cancer Death attributable to any cause.	Up to 10 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Distant relapse-free survival (DRFS) Time Frame: Up to 10 years	DRFS is defined as time from randomisation until date of first distant recurrence or death from any cause, whichever occurs first.	Up to 10 years
Overall survival (OS) Time Frame: Up to 10 years	OS is defined as time from randomisation until death from any cause.	Up to 10 years
Incidence and Severity of Adverse Events, with Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI-CTCAE v5.0) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Absolute and percent change from baseline in Clinical Laboratory Parameters Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Absolute and percent change from baseline in Vital Sign Parameters Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Proportion of patients experiencing each level of symptomatic AEs of arthralgia as measured by the EORTC-IL-194 item 10. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Proportion of patients experiencing each level of symptomatic AEs of hot flush as measured by the EORTC-IL-194 item 4. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Proportion of patients experiencing each level of symptomatic AEs of vaginal dryness as measured by the EORTC-IL-194 item 15. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Change from baseline and TTD (time to deterioration ) of health-related QoL (quality of life) as measured by the 2 global QoL items from the EORTC-QLQ-C30 items 11 and 12. EORTC-QLQ-C30 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Pharmacokinetics (PK) Time Frame: Until 6 months from treatment start	• Plasma concentrations of camizestrant pre-dose (Ctrough)( trough concentration)	Until 6 months from treatment start
Invasive disease-free survival (IDFS) Time Frame: Up to 10 years	IDFS is defined as time from randomisation until date of first occurrence of one of the following events: Invasive ipsilateral breast tumor recurrence (invasive IBTR) Locoregional invasive breast cancer recurrence Distant recurrence Invasive contralateral breast cancer Second primary non-breast invasive cancer Death attributable to any cause.	Up to 10 years
Change from baseline of arthralgia as measured by the EORTC-IL-194 (European Organisation for Research and Treatment of Cancer) item 10. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Change from baseline of hot flush as measured by the EORTC-IL-194 item 4. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)
Change from baseline of vaginal dryness as measured by the EORTC-IL-194 item 15. EORTC-IL-194 uses 0 - 4 scale (higher score is worse) Time Frame: Until 28 days after the final dose of study treatment (up to 5 years)		Until 28 days after the final dose of study treatment (up to 5 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

AstraZeneca

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Hamilton EP, Loibl S, Bachelot T, Gnant M, Niikura N, Park YH, Tolaney SM, Pistilli B, Rastogi P, Saini KS, Gioni I, Johnston S, Nunes R, Quintana A, Stuart M, Syta E, Walding A, Klinowska T, Mayer IA. CAMBRIA-1 & CAMBRIA-2 phase III trials: camizestrant versus standard endocrine therapy in ER+/HER2- early breast cancer. Future Oncol. 2025 Mar;21(7):795-806. doi: 10.1080/14796694.2025.2459548. Epub 2025 Feb 27.

Helpful Links

Description: Breast Cancer Study Locator details (for US)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 31, 2023

Primary Completion (Estimated)

April 20, 2027

Study Completion (Estimated)

May 29, 2036

Study Registration Dates

First Submitted

February 16, 2023

First Submitted That Met QC Criteria

March 7, 2023

First Posted (Actual)

March 20, 2023

Study Record Updates

Last Update Posted (Actual)

May 8, 2026

Last Update Submitted That Met QC Criteria

May 7, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

D8531C00002
2022-501024-20-00 (Other Identifier: EMA - CTIS)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal.

All request will be evaluated as per the AZ disclosure commitment:

https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

IPD Sharing Time Frame

AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

IPD Sharing Access Criteria

When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Breast Cancer, Early Breast Cancer

Assistance Publique - Hôpitaux de Paris

Recruiting

Real-life Evaluation of Endopredict® in Early HR+/HER2- Breast Cancer (SiMoSein)

HER2-negative Breast Cancer | Breast Cancer Survivors | Breast Cancer (Early Breast Cancer) | Breast Cancer Prognostic | Early Hormone Receptor-positive (HR-positive)

France
Fudan University

Not yet recruiting

De-escalation Therapy in Stage I ER-Positive Breast Cancer: A Non-Inferiority Trial (DESCENT)

Breast Cancer Early Stage Breast Cancer (Stage 1-3)

China
Peking University People's Hospital

Recruiting

ctDNA-Guided De-Escalation of Adjuvant Chemotherapy With Dalpiciclib in HR-Positive/HER2-Negative Breast Cancer (DNADalHR)

HER2-negative Breast Cancer | Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Hormone Receptor-Positive Breast Cancer | Early-Stage Breast Cancer | ctDNA Monitoring | High-risk Breast Cancer

China
Oncoliq US Inc

Recruiting

Validation of the Oncoliq Test for the Early Detection of Breast Cancer.

Breast Cancer Female | Breast Cancer Detection | Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Breast Cancer With Low to Intermediate HER2 Expression | Breast Cancer - Female | Breast Cancer (Early Breast Cancer) | Breast Cancer - Ductal Carcinoma in Situ (DCIS) | Breast Cancer - Infiltrating...

Argentina
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

Chemotherapy With or Without Adebrelimab and T-DXh as Neoadjuvant Therapy for HR+/HER2 Low Early Stage Breast Cancer

Breast Cancer Early Stage Breast Cancer (Stage 1-3) | HR Positive/HER2 Low Breast Cancer

China
Lucía Graña López

Recruiting

Luminal Breast Cancer Cryoablation (LUBRECA)

Breast Cancer | Breast Cancer (Early Breast Cancer)

Spain
The Netherlands Cancer Institute
BOOG Study Center; Stichting Treatmeds; Zorgevaluatie en Gepast Gebruik (ZE&GG); Integraal Kankercentrum Nederland (IKNL)

Not yet recruiting

Pembrolizumab Adjuvant in Patients With Early-stage Triple Negative Breast Cancer With Residual Disease After Neoadjuvant Pembrolizumab Plus Chemotherapy (PLANET)

Breast Cancer Stage II | Breast Cancer Stage III | Triple -Negative Breast Cancer | Early Stage Triple-Negative Breast Carcinoma | Triple Negative Breast Cancer (TNBC), Early Setting
University Hospital Tuebingen

Recruiting

Praegnant Breast Cancer: Early/Advanced/Metastatic (PRAEGNANT)

Advanced/Metastatic Breast Cancer | Breast Cancer (Early Breast Cancer)

Germany
M.D. Anderson Cancer Center

Active, not recruiting

Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Early Stage Triple-Negative Breast Carcinoma | Early Stage HER2-Positive Breast Carcinoma

United States
Hoffmann-La Roche

Recruiting

A Study to Assess Treatment Patterns and Treatment Adherence in Early HER2-positive Breast Cancer Participants After Treatment Decentralization (Close2HER)

Early-stage HER2+ Breast Cancer

Serbia

Clinical Trials on Tamoxifen

Karolinska Institutet
Region Stockholm; The Sjöberg Foundation; Swedish Cancer Society; The Swedish Breast... and other collaborators

Not yet recruiting

The POWER Trial: Personalised Dose Optimisation With Adjuvant Tamoxifen Therapy in Breast cancER (POWER)

Breast Cancer | Adjuvant Drug Therapy

Sweden
Ente Ospedaliero Ospedali Galliera
European Institute of Oncology; Fundacao Champalimaud

Completed

Long-term Follow-up of the TAM-01 Study and Pooled Analysis of Low-dose Tamoxifen Studies in Non-invasive or Microinvasive Breast Neoplasms (Babytam long)

Breast Cancer Invasive

Italy
Azienda Ospedaliera Universitaria Integrata Verona

Not yet recruiting

Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. (TMX)

Cystic Fibrosis - Complete

Italy
Uruk University

Completed

Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen

Breast Cancer | Endometrial Hyperplasia and Endometrial Cancers

Iraq
European Institute of Oncology
Istituto Oncologico Veneto IRCCS; Ente Ospedaliero Ospedali Galliera; Istituto...

Active, not recruiting

Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion (TOLERANT)

Ductal Carcinoma in Situ | RAD51C Gene Mutation | RAD51D Gene Mutation | PALB2 Gene Mutation | Lobular Carcinoma in Situ | ATM Gene Mutation | CDH1 Gene Mutation | CHEK2 Gene Mutation | BRCA Mutation

Italy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

External Mastalgia-oil Versus Oral Tamoxifen in Premenopausal Women with Severe Mastalgia

Mastalgia

China
Northwestern University
National Cancer Institute (NCI)

Completed

4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ

Estrogen Receptor-positive Breast Cancer | Ductal Breast Carcinoma in Situ

United States
The Methodist Hospital Research Institute
Millennium Pharmaceuticals, Inc.

Completed

TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancer (ANETT)

Estrogen Receptor Positive Breast Cancer

United States
University of Nebraska

Recruiting

Chemoprevention With Tamoxifen in Pre-Invasive Pancreas Mucinous Cystic Neoplasms Not Undergoing Immediate Resection (MCN_Tam)

Pancreatic Cyst | Pancreatic Mucinous Cystic Neoplasm

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer

Breast Cancer | Stage IV Breast Cancer

United States, Canada, Peru

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy (CAMBRIA-1)

Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Breast Cancer, Early Breast Cancer

Clinical Trials on Tamoxifen

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in United Kingdom

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations