The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

April 17, 2026 updated by: Eli Lilly and Company

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

10000

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1426ABP
        • Fundación Respirar
      • Buenos Aires, Argentina, C1120AAC
        • Centro Médico Viamonte
      • Buenos Aires, Argentina, C1407GTN
        • CEMEDIC
      • Buenos Aires, Argentina, 1012
        • CONEXA Investigacion Clinica S.A.
      • Buenos Aires, Argentina, 1061
        • Buenos Aires Macula S.A
      • Buenos Aires, Argentina, 1425
        • Cardiología Palermo
      • Buenos Aires, Argentina, C1023AAB
        • Stat Research S.A.
      • Buenos Aires, Argentina, C1061AAS
        • CIPREC
      • Buenos Aires, Argentina, C1425AGC
        • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
      • Buenos Aires, Argentina, C1128AAF
        • Mautalen Salud e Investigacion
      • Buenos Aires, Argentina, C1430CKE
        • Glenny Corp. S.A.
      • Buenos Aires, Argentina, C1056ABH
        • Investigaciones Medicas IMOBA SRL
      • Buenos Aires, Argentina, 1424
        • Cicemo Srl
      • Buenos Aires, Argentina, 1056ABI
        • Centro de Investigaciones Metabólicas (CINME)
      • Buenos Aires, Argentina, C1119
        • CIPREC
      • C.a.b.a., Argentina, C1205AAO
        • CEMEDIAB
      • CABA, Argentina, C1060ABN
        • CEDIC
      • CABA, Argentina, C1405BCG
        • Instituto Médico Especializado (IME)
      • Capital, Argentina, X5008HHW
        • Centro Medico Privado CEMAIC
      • Ciudad de Buenos Aires, Argentina, C1012AAR
        • IDIM - Instituto de Investigaciones Metabólicas
      • Córdoba, Argentina, 5000
        • Centro Diabetológico Dr. Waitman
      • Córdoba, Argentina, 5000
        • Instituto de Investigaciones Clinicas Cordoba
      • Córdoba, Argentina, X5000AVE
        • CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
      • Córdoba, Argentina, 5002
        • Sanatorio Privado Duarte Quirós
      • Córdoba, Argentina, 5003
        • Centro Médico Colón
      • Córdoba, Argentina, 5006
        • Centro Medico Privado San Vicente Diabetes
      • Godoy Cruz, Argentina, M5501ARP
        • CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
      • Granadero Baigorria, Argentina, 2152
        • Centro de Investigaciones Clínicas Baigorria
      • Junín, Argentina, 6000
        • CMD-Centro Médico y Diagnóstico por Imágenes
      • La Plata, Argentina, 1900
        • Hospital Italiano de La Plata
      • Lanus, Argentina, B1824KAJ
        • CIMeL
      • Lujan de Cuyo, Argentina, 5509
        • Polo de Salud Vistalba
      • Mar del Plata, Argentina, 7600
        • Centro de Investigaciones Medicas Mar Del Plata
      • Mar del Plata, Argentina, B7600FZO
        • Instituto de Investigaciones Clinicas Mar del Plata
      • Quilmes, Argentina, 1878
        • Instituto de Investigaciones Clinicas Quilmes
      • Ramos Mejía, Argentina, B1704ETD
        • DIM Clinica Privada
      • Rosario, Argentina, S2002KDS
        • Hospital Provincial del Centenario
      • Rosario, Argentina, 2000
        • INECO Neurociencias Orono
      • Rosario, Argentina, 2000
        • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
      • Rosario, Argentina, 2000
        • Instituto Médico Catamarca IMEC
      • Rosario, Argentina, 2000
        • Instituto Especialidades de la Salud Rosario
      • Rosario, Argentina, S2000CVD
        • Instituto de Investigaciones Clinicas Rosario
      • Rosario, Argentina, 2000
        • Fundacion Estudios Clinicos
      • Rosario, Argentina, S2000DTB
        • Laboratorio de Hemostasia y Trombosis
      • Río Cuarto, Argentina, X5800AEV
        • Instituto Medico Rio Cuarto
      • SAN M. de Tucuman, Argentina, T4000AXL
        • Centro de Investigaciones Medicas Tucuman
      • San Martin, Argentina, 1650
        • Corporación Médica San Martín
      • San Miguel de Tucumán, Argentina, 4000
        • Investigaciones Clinicas Tucuman
      • San Miguel de Tucumán, Argentina, 4000
        • Centro Modelo de Cardiología
      • San Nicolás, Argentina, 2900
        • Go Centro Medico San Nicolás
      • Santa Fe, Argentina, S3000FWO
        • Centro de Investigaciones Clinicas del Litoral
      • Santa Fe, Argentina, 3000
        • Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
      • Santa Fe, Argentina, 3000
        • Centro de Diagnóstico y Rehabilitación (CEDIR)
      • Santa Rosa, Argentina, 6300
        • Centro de Salud e Investigaciones Médicas
      • Santiago del Estero, Argentina, 4200
        • Sanatorio Norte
      • Temperley, Argentina, 1834
        • Centro de Investigaciones Médicas Temperley
      • Venado Tuerto, Argentina, 2600
        • Sanatorio San Martin
      • Villa Domínico, Argentina, 1874
        • CEREHA
      • Zárate, Argentina, B2800DGH
        • Instituto de Investigaciones Clínicas Zarate
  • Australia
      • Adelaide, Australia, 5000
        • Nightingale Research
      • Botany, Australia, 2019
        • Emeritus Research
      • Box Hill, Australia, 3128
        • Box Hill Hospital
      • Brisbane, Australia, 4029
        • Royal Brisbane and Women's Hospital
      • Brookvale, Australia, 2100
        • Northern Beaches Clinical Research
      • Camberwell, Australia, 3124
        • Emeritus Research
      • Garran, Australia, 2605
        • Canberra Hospital
      • Geelong, Australia, 3220
        • Barwon Health
      • Heidelberg West, Australia, 3081
        • Austin Health - Repatriation Hospital
      • Meadowbrook, Australia, 4131
        • Logan Hospital
      • Melbourne, Australia, 3004
        • The Alfred Hospital
      • Merewether, Australia, 2291
        • The AIM Centre / Hunter Diabetes Centre
      • Murdoch, Australia, 6150
        • Fiona Stanley Hospital
      • Oaklands Park, Australia, 5046
        • Southern Adelaide Diabetes & Endocrine Services
      • St Leonards, Australia, 2065
        • Royal North Shore Hospital
      • Sydney, Australia, 2006
        • University of Sydney - Charles Perkins Centre
  • Austria
      • Braunau am Inn, Austria, 5280
        • Krankenhaus St. Josef Braunau
      • Feldkirch, Austria, 6800
        • VIVIT
      • Graz, Austria, 8036
        • Medizinische Universitat Graz
      • Innsbruck, Austria, 6020
        • Medizinische Universitaet Innsbruck
      • Linz, Austria, 4021
        • Konventhospital der Barmherzigen Brüder Linz
      • Mattersburg, Austria, 7210
        • Cardio Metabolic Centre
      • Sankt Stefan ob Stainz, Austria, 8511
        • Private Practice - Dr. Evelyn Fliesser-Gorzer
      • Vienna, Austria, 1030
        • Klinik Landstraße
      • Vienna, Austria, 1060
        • Zentrum für klinische Studien Dr Hanusch Gmbh
      • Vienna, Austria, 1090
        • Universitaetsklinikum Allgemeines Krankenhaus Wien
      • Vienna, Austria, 1130
        • Klinik Hietzing
      • Vienna, Austria, 1190
        • Imed19-privat
  • Belgium
      • Aalst, Belgium, 9300
        • AZORG Campus Aalst-Moorselbaan
      • Alken, Belgium, 3570
        • ANIMA Research
      • Bonheiden, Belgium, 2820
        • Imelda General Hospital
      • Brasschaat, Belgium, 2930
        • Algemeen Ziekenhuis klina
      • Brussels, Belgium, 1200
        • Cliniques Universitaires Saint-luc
      • Brussels, Belgium, 1090
        • UZ Brussel
      • Brussels, Belgium, 1020
        • Centre Hospitalier Universitaire Brugmann
      • Brussels, Belgium, 1070
        • Université Libre de Bruxelles - Hôpital Erasme
      • Edegem, Belgium, 2650
        • Antwerp University Hospital
      • Ghent, Belgium, 9000
        • UZ Gent
      • Hasselt, Belgium, 3500
        • Jessa Ziekenhuis
      • Ieper, Belgium, 8900
        • Jan Yperman Ziekenhuis
      • Kluisbergen, Belgium, 9690
        • Kormont
      • Kortrijk, Belgium, 8500
        • AZ Groeninge Campus Kennedylaan
      • Leuven, Belgium, 3000
        • UZ Leuven
      • Liège, Belgium, 4000
        • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
      • Merksem, Belgium, 2170
        • ZNA Jan Palfijn
      • Ostend, Belgium, 8400
        • Az Damiaan vzw
      • Oudenaarde, Belgium, 9700
        • Artsenpraktijk OHIO
      • Tielt, Belgium, 8700
        • Private Practice - Dr. De Watertoren
      • Zwalm, Belgium, 9630
        • Private Practice - Dr. Tim Decraecke (Zwalm)
  • Brazil
      • Aracaju, Brazil, 49055-530
        • Centro de Pesquisa Clinica do Coracao
      • Belo Horizonte, Brazil, 30150-221
        • Santa Casa de Misericordia de Belo Horizonte
      • Belo Horizonte, Brazil, 30150-320
        • Freire Pesquisa Clinica
      • Belém, Brazil, 66073-000
        • Hospital Universitário João de Barros Barreto
      • Blumenau, Brazil, 89020-430
        • AngioKormann Blumenau
      • Brasília, Brazil, 72145-450
        • Chronos Pesquisa Clínica
      • Brasília, Brazil, 70200730
        • L2IP - Instituto de Pesquisas Clínicas
      • Campinas, Brazil, 13060-080
        • Instituto de Pesquisa Clinica de Campinas
      • Campinas, Brazil, 13060-803
        • Centro de Pesquisa Sao Lucas
      • Campinas, Brazil, 13073-350
        • Centro de Endocrinologia Geloneze
      • Caxias do Sul, Brazil, 95070-560
        • Fundação Universidade de Caxias do Sul (FUCS)
      • Curitiba, Brazil, 80030-480
        • Cline Research Center
      • Curitiba, Brazil, 80810-040
        • Centro de Diabetes Curitiba
      • Curitiba, Brazil, 80040-110
        • Quanta Diagnóstico e Terapia
      • Curitiba, Brazil, 80230-130
        • PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR
      • Curitiba, Brazil, 80240-220
        • Instituto Pro Renal Brasil
      • Fortaleza, Brazil, 60160-230
        • Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE
      • Fortaleza, Brazil, 60430-350
        • Private Practice - Dr.Miguel N. Hissa
      • Fortaleza, Brazil, 60.125-058
        • Instituto de Ensino e Pesquisa Clinica do Ceara
      • Goiânia, Brazil, 74605-020
        • Universidade Federal de Goias
      • Maceió, Brazil, 57051-160
        • Centro de Pesquisas Clínicas Dr. Marco Mota
      • Manaus, Brazil, 69057-088
        • CPHOSP Manaus Medicina, Ensino e Pesquisa
      • Marília, Brazil, 17504-072
        • Centro de Pesquisa Clínica de Marília - CPCLIM
      • Passo Fundo, Brazil, 99010-120
        • Instituto Mederi de Pesquisa e Saude
      • Porto Alegre, Brazil, 90430-001
        • Núcleo de Pesquisa Clínica do Rio Grande do Sul
      • Rio de Janeiro, Brazil, 22270-060
        • Ruschel Medicina e Pesquisa Clínica
      • Rio de Janeiro, Brazil, 20241-180
        • IBPClin - Instituto Brasil de Pesquisa Clínica
      • Rio de Janeiro, Brazil, 22280-003
        • Hospital Pro-Cardiaco
      • Salvador, Brazil, 40415-065
        • Clinica Senhor do Bonfim CSB - Salvador
      • Santo André, Brazil, 09080-110
        • Pesquisare Saude
      • Santo André, Brazil, 09790790
        • Praxis Pesquisa Médica
      • São Bernardo do Campo, Brazil, 09715-090
        • Centro Multidisciplinar de Estudos Clinicos
      • São José do Rio Preto, Brazil, 15090000
        • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
      • São José dos Campos, Brazil, 12243-280
        • ISPEM - Instituto São Jose dos Campos em Pesquisas Medicas
      • São Paulo, Brazil, 01228-000
        • CPQuali Pesquisa Clínica
      • São Paulo, Brazil, 04266-010
        • CEPIC - Centro Paulista de Investigação Clínica
      • São Paulo, Brazil, 01323-903
        • Hospital Alemao Oswaldo Cruz
      • São Paulo, Brazil, 01228-200
        • CPCLIN
      • São Paulo, Brazil, 05403-000
        • Hospital das Clinicas FMUSP
      • São Paulo, Brazil, 01236030
        • BR Trials - Ensaios Clinicos e Consultoria
      • São Paulo, Brazil, 04014-002
        • IBCC - Núcleo de Pesquisa e Ensino
      • São Paulo, Brazil, 01223-001
        • Instituto de Pesquisa Clinica
      • São Paulo, Brazil, 01321-001
        • BP - A Beneficencia Portuguesa de São Paulo
      • São Paulo, Brazil, 05403-000
        • Incor - Instituto do Coracao
      • Tatuí, Brazil, 18270-170
        • Instituto de Molestias Cardiovasculares de Tatui
      • Uberlândia, Brazil, 38400-500
        • Eurolatino Pesquisas Medicas
      • Vitória, Brazil, 29055450
        • CEDOES
      • Votuporanga, Brazil, 15500-269
        • INTEGRAL Pesquisa e Ensino
  • Canada
      • Calgary, Canada, T2V 4J2
        • C-health Research
      • Chicoutimi, Canada, G7H 7K9
        • Ecogene-21
      • Courtice, Canada, L1E 2J5
        • Med Trust Research
      • Edmonton, Canada, T6H 2L4
        • C-health
      • London, Canada, N6A 5W9
        • Victoria Hospital & Children's Hospital - London Health Sciences Centre
      • London, Canada, N6A 4V2
        • St. Joseph's Health Care
      • London, Canada, N6G 2M1
        • Western Centre for Public Health and Family Medicine
      • Moncton, Canada, E1G 1A7
        • G A Research Associates
      • North York, Canada, M6B 3H7
        • North York Diagnostic and Cardiac Centre
      • Oshawa, Canada, L1G 2B9
        • Lakeridge Health
      • Québec, Canada, G2J 0C4
        • Alpha Recherche Clinique
      • Saint-Jérôme, Canada, J7Z 2V4
        • Unite de Recherche Clinique du CISSS des Laurentides
      • Surrey, Canada, V3V 0C6
        • SMH Cardiology Clinical Trials
      • Surrey, Canada, V3S 2N6
        • Ocean West Research Clinic
      • Sydney, Canada, B1M 0A1
        • Care Access - Cape Breton
      • Thunder Bay, Canada, P7B 7C7
        • Care Access - Thunder Bay - Barton Street
      • Toronto, Canada, M5G 2C4
        • Toronto General Hospital
      • Toronto, Canada, M1B 5N1
        • Corcare
      • Waterloo, Canada, N2T 0C1
        • Clinical Research Solutions - Kitchener
      • Winchester, Canada, K0C 2K0
        • Winchester District Memorial Hospital
      • Winnipeg, Canada, R3C 0N2
        • Winnipeg Clinic
      • Winnipeg, Canada, R2V 3M3
        • Seven Oaks General Hospital
  • Czechia
      • Brandýs nad Labem, Czechia, 250 01
        • MEDICUS SERVICES s.r.o., kardiologicka ambulance
      • Brno, Czechia, 636 00
        • Vojenska nemocnice Brno
      • Brno, Czechia, 60200
        • Fakultni nemocnice u sv. Anny v Brne
      • Brno, Czechia, 602 00
        • Fakultni nemocnice u sv. Anny v Brne
      • Brno, Czechia, 602 00
        • UNIVMED
      • Chlumec nad Cidlinou, Czechia, 503 51
        • Kardio Chlumec
      • Holešov, Czechia, 769 01
        • Diahaza s.r.o.
      • Kolín, Czechia, 280 02
        • Kardioma
      • Litovel, Czechia, 784 01
        • Kardiologicka ambulance
      • Náchod, Czechia, 547 01
        • EDUMED - Náchod
      • Olomouc, Czechia, 779 00
        • PreventaMed
      • Olomouc, Czechia, 779 00
        • Agentura Science Pro
      • Olomouc, Czechia, 779 00
        • Diabetologické centrum s.r.o.
      • Ostrava, Czechia, 702 00
        • Private Practice - Dr. Miroslav Koliba
      • Ostrava, Czechia, 710 00
        • Donmed s.r.o.
      • Ostrava - Dubina, Czechia, 700 30
        • Kardiologicka a Angiologicka Ambulance
      • Prague, Czechia, 14059
        • Fakultni Thomayerova nemocnice
      • Prague, Czechia, 149 00
        • Nefrologie
      • Prague, Czechia, 140 00
        • MEDICON
      • Prague, Czechia, 158 00
        • Poliklinika Lípa Centrum
      • Prague, Czechia, 18100
        • ResTrial s.r.o.
      • Prague, Czechia, 110 00
        • MUDr. Jana Parkanyiova
      • Prague, Czechia, 169 00
        • Centrum Kardiovaskularni Mediciny
      • Prague, Czechia, 169 00
        • Diabetologie a endokrinologie, J.Venerová
      • Prague, Czechia, 120 00
        • Synexus Czech
      • Prague, Czechia, 160 00
        • FLEDIP - Na dlouhem lanu
      • Praha 9 - Klanovice, Czechia, 190 14
        • MUDr. Barbora Diepoltova
      • Přeštice, Czechia, 334 01
        • Diakom, s.r.o. - Přeštice
      • Trutnov, Czechia, 541 01
        • Kardiologicka ambulance MUDr. Ferkl s.r.o.
      • Uherské Hradiště, Czechia, 686 01
        • Clinical Trials Service s.r.o.
      • Zlín, Czechia, 760 01
        • Cardio Research, s.r.o
      • Český Krumlov, Czechia, 381 01
        • Nemocnice Cesky krumlov
  • Denmark
      • Aabenraa, Denmark, 6200
        • Sygehus Sønderjylland i Aabenraa
      • Aarhus, Denmark, 8200
        • Aarhus Universitetshospital, Skejby
      • Gandrup, Denmark, 9362
        • Sanos Clinic - Nordjylland
      • Herlev, Denmark, 2730
        • Herlev and Gentofte Hospital
      • Herlev, Denmark, 2730
        • Sanos Clinic
      • Vejle, Denmark, 7100
        • Sanos Clinic - Syddanmark
  • France
      • Bois-Guillaume, France, 76230
        • Centre Hospitalier Universitaire - Hôpitaux de Rouen - Hôpital de Bois-Guillaume
      • Bordeaux, France, 33076
        • Bordeaux University Hospital - Pellegrin
      • Clermont-Ferrand, France, 63000
        • Chu Gabriel Montpied
      • Corbeil-Essonnes, France, 91106
        • Centre Hospitalier Sud Francilien
      • La Tronche, France, 38700
        • Chu Grenoble Alpes
      • Le Coudray, France, 28630
        • Centre Hospitalier Louis Pasteur
      • Montpellier, France, 34295
        • CHU Montpellier Lapeyronie Hospital
      • Nantes, France, 44093
        • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
      • Nice, France, 06000
        • Centre Hospitalier Universitaire de Nice - Hopital Pasteur
      • Paris, France, 75015
        • Hôpital Européen Georges Pompidou
      • Paris, France, 75014
        • Groupe hospitalier Paris saint Joseph
      • Paris, France, 75013
        • Pitie Salpetriere University Hospital
      • Pessac, France, 33600
        • CHU Bordeaux Haut-Leveque
      • Toulouse, France, 31059
        • CHU Rangueil
      • Tours, France, 37000
        • Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
      • Valenciennes, France, 59300
        • Polyclinique Vauban
  • Germany
      • Bad Nauheim, Germany, 61231
        • Kerckhoff-Klinik
      • Bad Oeynhausen, Germany, 32545
        • Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
      • Berlin, Germany, 10629
        • FutureMeds GmbH
      • Bremen, Germany, 28277
        • Kardiologisch-Angiologische Praxis - Herzzentrum Bremen
      • Dortmund, Germany, 44137
        • St.-Johannes-Hospital Dortmund
      • Dresden, Germany, 01307
        • Universitaetsklinikum Carl Gustav Carus Dresden
      • Dresden, Germany, 01277
        • Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
      • Elsterwerda, Germany, 04910
        • ZKS Suedbrandenburg
      • Essen, Germany, 45136
        • InnoDiab Forschung GmbH
      • Essen, Germany, 45359
        • Unterfrintroper Hausarztzentrum Klinische Forschung
      • Frankfurt, Germany, 60590
        • Universitätsklinikum Frankfurt Goethe-Universität
      • Hamburg, Germany, 21109
        • Diabetes Zentrum Wilhelmsburg
      • Hamburg, Germany, 22041
        • Diabetes Zentrum Wandsbek
      • Hanover, Germany, 30625
        • Zentrum für Nieren-, Hochdruck- und Stoffwechselerkrankungen - Heidering
      • Leipzig, Germany, 04107
        • AmBeNet GmbH
      • Lübeck, Germany, 23562
        • Universität zu Lübeck - Institut für Endokrinologie und Diabetes
      • Mainz, Germany, 55131
        • Universitätsmedizin Johannes Gutenberg Universität Mainz
      • Mannheim, Germany, 68167
        • Universitätsmedizin Mannheim
      • Mannheim, Germany, 68167
        • CRS Clinical Research Services Mannheim
      • Münster, Germany, 48145
        • Institut für Diabetesforschung GmbH Münster
      • Oldenburg, Germany, 23758
        • RED-Institut GmbH
      • Papenburg, Germany, 26871
        • Kardiologische Praxis Papenburg
      • Saint Ingbert, Germany, 66386
        • Zentrum für klinische Studien
      • Villingen-Schwenningen, Germany, 78052
        • Nephrologisches Zentrum Villingen-Schwenningen
      • Wangen, Germany, 88239
        • Praxis Sauter & Sauter & Vorbach
  • Greece
      • Athens, Greece, 11527
        • General Hospital of Athens Laiko
      • Athens, Greece, 11527
        • General Hospital of Athens "G. Gennimatas"
      • Athens, Greece, 151 25
        • Athens Medical Center
      • Athens, Greece, 115 25
        • Athens Medical Center - Psychikon branch
      • Ioannina, Greece, 455 00
        • University Hospital of Ioannina
      • Larissa, Greece, 41110
        • University General Hospital of Larissa
      • Palaió Fáliro, Greece, 17562
        • Iatriko Paleou Falirou Medical Center
      • Thessaloniki, Greece, 546 45
        • EUROMEDICA General Clinic of Thessaloniki
      • Thessaloniki, Greece, 564 29
        • 424 Military General Training Hospital
      • Thessaloniki, Greece, 546 35
        • G. Gennimatas General Hospital of Thessaloniki
      • Thessaloniki, Greece, 564 03
        • Papageorgiou General Hospital Of Thessaloniki
  • Hungary
      • Balatongyörök, Hungary, 8313
        • DRC Gyógyszervizsgáló Központ
      • Budapest, Hungary, 1122
        • Semmelweis University
      • Budapest, Hungary, 1036
        • Óbudai Egészségügyi Centrum
      • Budapest, Hungary, 1032
        • Szent Margit Rendelintézet
      • Budapest, Hungary, 1062
        • Észak-Pesti Centrumkórház-Honvédkórház
      • Budapest, Hungary, H-1046
        • Újpesti Egészségügyi Nonprofit Kft
      • Budapest, Hungary, 1102
        • PVN Kutató Kft
      • Budapest, Hungary, 1132
        • Privát Doktor Egészségügyi Zrt
      • Debrecen, Hungary, 4032
        • Debreceni Egyetem Klinikai Kozpont
      • Kistarcsa, Hungary, 2143
        • CRU Early Phase Unit
      • Komárom, Hungary, 2900
        • Selye János Kórház
      • Szeged, Hungary, 6725
        • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
      • Szolnok, Hungary, 5000
        • Allergo-Derm Bakos Kft
      • Zalaegerszeg, Hungary, 8900
        • Zala Megyei Szent Rafael Kórház
  • India
      • Allahābād, India, 211002
        • Motilal Nehru Medical College Hospital
      • Bangalore, India, 560092
        • Life Care Hospital and Research Centre
      • Bhubaneswar, India, 751019
        • All India Institute of Medical Sciences
      • Bikaner, India, 334001
        • Sardar Patel Medical College
      • Chennai, India, 600024
        • Medway Hospitals - Kodambakkam
      • Dehradun, India, 248001
        • Shri Mahant Indiresh Hospital
      • Guntur, India, 522001
        • Endolife Speciality Hospitals
      • Kanpur, India, 208001
        • K care Hospital
      • Kanpur, India, 208019
        • LPS Institute of Cardiology
      • Kozhikode, India, 673008
        • Government Medical College - Kozhikode
      • Lucknow, India, 226010
        • Dr. Ram Manohar Lohia Institute of Medical Sciences
      • Mysore, India, 570015
        • Manipal Hospitals
      • Nagpur, India, 440001
        • Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)
      • Nagpur, India, 441108
        • All India Institute of Medical Sciences (AIIMS) - Nagpur
      • Nagpur, India, 440012
        • Shrikrishna Hrudayalaya And Critical Care Center
      • New Delhi, India, 110060
        • Sir Ganga Ram Hospital
      • New Delhi, India, 110002
        • G.B. Pant Institute of Postgraduate Medical Education & Research
      • Surat, India, 395002
        • Nirmal Hospital Pvt Ltd.
      • Surat, India, 395002
        • Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute
  • Israel
      • Ashkelon, Israel, 7830604
        • Barzilai Medical Center
      • Haifa, Israel, 3109601
        • Rambam Health Care Campus
      • Haifa, Israel, 3339419
        • Bnai Zion Medical Center
      • Jerusalem, Israel, 9112001
        • Hadassah Medical Center
      • Jerusalem, Israel, 9013102
        • Shaare Zedek Medical Center
      • Kfar Saba, Israel, 4428164
        • Meir Medical Center
      • Nahariya, Israel, 2210001
        • Galilee Medical Center
      • Petah Tikva, Israel, 49100
        • Rabin Medical Center
      • Petah Tikva, Israel, 4941492
        • Rabin Medical Center
      • Petah Tikva, Israel, 4937211
        • Rabin Medical Center - Hasharon Campus
      • Ramat Gan, Israel, 5262100
        • Sheba Medical Center
      • Rehovot, Israel, 7610001
        • Kaplan Medical Center
      • Tel Aviv, Israel, 68125
        • Maccabi Healthcare Services
      • Tel Aviv, Israel, 6423906
        • Sourasky Medical Center
      • Tel Aviv, Israel, 6937947
        • Diabetes Medical Center
      • Ẕerifin, Israel, 70300
        • Yitzhak Shamir Medical Center
  • Italy
      • Bologna, Italy, 40138
        • IRCCS - AOU di Bologna
      • Bologna, Italy, 40138
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
      • Ferrara, Italy, 44124
        • Azienda Ospedaliero Universitaria S.Anna
      • Genova, Italy, 16132
        • Ospedale San Martino
      • Milan, Italy, 20132
        • Ospedale San Raffaele
      • Milan, Italy, 20138
        • Centro Cardiologico Monzino
      • Palermo, Italy, 90127
        • A.O.U. Policlinico Paolo Giaccone
      • Perugia, Italy, 06132
        • AO Santa Maria della Misericordia
      • Pisa, Italy, 56126
        • Azienda Ospedaliero Universitaria Pisana
      • Pisa, Italy, 56124
        • Azienda Ospedaliera Universitaria Pisana
      • Roma, Italy, 00161
        • AOU Policlinico Umberto I
      • Roma, Italy, 00168
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
      • Rome, Italy, 00128
        • Fondazione Policlinico Universitario Campus Bio-Medico
      • San Donato Milanese, Italy, 20097
        • IRCCS Policlinico San Donato
  • Mexico
      • Actopan, Mexico, 42500
        • Centro de Atencion al Diabetico Actopan
      • Aguascalientes, Mexico, 20230
        • Fundación Cardiovascular de Aguascalientes A.C.
      • Ciudad Madero, Mexico, 89440
        • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
      • Cuauhtémoc, Ciudad de México, Mexico, 06100
        • Cryptex Investigación Clínica S.A. de C.V.
      • Cuernavaca, Mexico, 62250
        • Instituto de Diabetes, Obesidad y Nutricion
      • Cuernavaca, Mexico, 62448
        • Investigación Clínica Cuernavaca, S.C.
      • Durango, Mexico, 34000
        • Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
      • Durango, Mexico, 34000
        • Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
      • Guadalajara, Mexico, 44130
        • Diseno y Planeacion en Investigacion Medica
      • Guadalajara, Mexico, 44670
        • Private Practice - Dr. Arechavaleta Granell Maria del Rosario
      • Guadalajara, Mexico, 04460
        • Instituto Jalisciense de Investigacion en Diabetes y Obesidad
      • Guadalajara, Mexico, 44670
        • Virgen Cardiovascular Research SC
      • Guadalajara, Mexico, 44340
        • Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
      • Guadalajara, Mexico, 44690
        • CINVEC Medica
      • León, Mexico, 37530
        • Instituto Cardiovascular de León S.C.
      • Mexicali, Mexico, 21200
        • Centro de Investigacion en Artritis y Osteoporosis SC
      • Mexico City, Mexico, 14080
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
      • Mexico City, Mexico, 06090
        • Hospital de Jésus, I.A.P.
      • Mexico City, Mexico, 11650
        • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
      • Mexico City, Mexico, 06700
        • Clinica Omega
      • Monterrey, Mexico, 64460
        • UBAM Unidad Biomedica Avanzada Monterrey
      • Monterrey, Mexico, 64060
        • Cardiolink Clin Trials
      • Monterrey, Mexico, 64060
        • IMED Internal Medicine Clin Trials
      • Monterrey, Mexico, 66460
        • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
      • Monterrey, Mexico, 64610
        • Clínica García Flores SC
      • Monterrey, Mexico, 64040
        • Servicios de Oncología Medica Integral - Monterrey - José Benitez
      • Mérida, Mexico, 97000
        • Eme Red Hospitalaria
      • Mérida, Mexico, 97070
        • Medical Care and Research SA de CV
      • México, Mexico, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
      • México, Mexico, 06700
        • Clinstile, S.A. de C.V.
      • Oaxaca City, Mexico, 68020
        • Centro de Investigacion Clinica de Oaxaca
      • Puebla City, Mexico, 72160
        • Boca Clinical Trials Mexico SC
      • Querétaro, Mexico, 76000
        • Centro de Estudios Clínicos de Querétaro (CECLIQ)
      • Querétaro, Mexico, 76090
        • PanAmerican Clinical Research - Querétaro - Avenida Antea
      • San Luis Potosí City, Mexico, 78200
        • Centro de Atención e Investigación Cardiovascular del Potosí
      • San Nicolás de los Garza, Mexico, 66465
        • Centro de investigación y control metabólico
      • Tlalpan, Mexico, 14050
        • Medimanage Research
      • Veracruz, Mexico, 91900
        • FAICIC S. de R.L. de C.V.
      • Veracruz, Mexico, 91851
        • Instituto Veracruzano en Investigación Clínica S.C.
      • Veracruz, Mexico, 91900
        • Arké SMO S.A de C.V
      • Xalapa, Mexico, 91193
        • Consultorio de Medicina Especilizada del Sector Privado
  • Netherlands
      • Alkmaar, Netherlands, 1815 JD
        • Noordwest Ziekenhuisgroep
      • Almere Stad, Netherlands, 1311 RL
        • EB Medical Research
      • Amersfoort, Netherlands, 3813 TZ
        • Meander Medisch Centrum
      • Amsterdam, Netherlands, 1105 AZ
        • Amsterdam UMC, locatie AMC
      • Amsterdam, Netherlands, 1091 AC
        • OLVG Oost
      • Apeldoorn, Netherlands, 7334 DZ
        • Gelre Ziekenhuis
      • Beverwijk, Netherlands, 1942 LE
        • Rode Kruis Ziekenhuis
      • Breda, Netherlands, 4818 CK
        • Amphia Ziekenhuis, locatie Breda Molengracht
      • Dirksland, Netherlands, 3247 BW
        • Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland
      • Dordrecht, Netherlands, 3318 AT
        • Albert Schweitzer Ziekenhuis, locatie Dordwijk
      • Ede, Netherlands, 6716 RP
        • Ziekenhuis Gelderse Vallei
      • Eindhoven, Netherlands, 5623 EJ
        • Catharina Ziekenhuis
      • Enschede, Netherlands, 7512 KZ
        • Medisch Spectrum Twente
      • Haarlem, Netherlands, 2035 RC
        • Spaarne Gasthuis, Haarlem Zuid
      • Heerlen, Netherlands, 6419 PC
        • Atrium-Orbis - Zuyderland Medisch Centrum Heerlen
      • Hoogeveen, Netherlands, 7909 AA
        • Ziekenhuis Bethesda
      • Leeuwarden, Netherlands, 8934 AD
        • Medische Centrum Leeuwarden
      • Nijmegen, Netherlands, 6525 GA
        • Radboudumc
      • Roosendaal, Netherlands, 4708 AE
        • Bravis Ziekenhuis, locatie Roosendaal
      • Rotterdam, Netherlands, 3045 PM
        • Franciscus Gasthuis & Vlietland, Locatie Gasthuis
      • The Hague, Netherlands, 2565 KV
        • Medisch Centrum Thomsonplein
      • The Hague, Netherlands, 2572 GM
        • Huisartsenpraktijk Disha
      • Tiel, Netherlands, 4002 WP
        • Ziekenhuis Rivierenland
      • Utrecht, Netherlands, 3584 CX
        • Universitair Medisch Centrum Utrecht
      • Venlo, Netherlands, 5912 BL
        • VieCuri Medisch Centrum, locatie Venlo
      • Zwijndrecht, Netherlands, 3334 SB
        • Dokters van Nederhoven
      • Zwijndrecht, Netherlands, 3333 GZ
        • Huisartsenpraktijk Broekman
      • Zwolle, Netherlands, 8025 AB
        • Isala, locatie Zwolle
  • New Zealand
      • Auckland, New Zealand, 2025
        • Aotearoa Clinical Trials
      • Auckland, New Zealand, 0622
        • Pacific Clinical Research Network - Auckland (PCRN Auckland)
      • Nelson, New Zealand, 7011
        • Pacific Clinical Research Network - Tasman
      • Papamoa, New Zealand, 3118
        • Lakeland Clinical Trials Culloden
      • Pukekohe, New Zealand, 2120
        • Momentum Clinical Research - Pukekohe
      • Silverdale, New Zealand, 0932
        • PCRN Silverdale Medical
      • Tauranga, New Zealand, 3110
        • Momentum Clinical Research - Tauranga
      • Upper Hutt, New Zealand, 5018
        • Lakeland Clinical Trials Wellington
      • Whangarei, New Zealand, 0110
        • Aotearoa Clinical Trials - Whangarei
  • Poland
      • Bialystok, Poland, 15-704
        • KLIMED Marek Klimkiewicz
      • Bielsko-Biala, Poland, 43-300
        • Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny
      • Bydgoszcz, Poland, 85-231
        • NZOZ Centrum Medyczne KERmed
      • Bydgoszcz, Poland, 85-605
        • Centrum Medyczne Intercor Sp. z o.o.
      • Chorzów, Poland, 41-500
        • Diab Serwis Popenda Spółka Jawna
      • Chrzanów, Poland, 32-500
        • Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe
      • Elblag, Poland, 82-300
        • Centrum Kliniczno-Badawcze
      • Gdansk, Poland, 80-952
        • Uniwersyteckie Centrum Kliniczne
      • Krakow, Poland, 31-261
        • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
      • Leszno, Poland, 64-100
        • Poliklinika Kardiologiczna Serce
      • Lodz, Poland, 91-473
        • Pro Salus Centrum Medyczne
      • Lublin, Poland, 20-044
        • CenterMed Lublin NZOZ
      • Lublin, Poland, 20-718
        • Ekamed
      • Opole, Poland, 45-301
        • EndoPractica
      • Poznan, Poland, 60-589
        • Centrum Zdrowia Metabolicznego Pawel Bogdanski
      • Przemyśl, Poland, 37-700
        • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
      • Tarnów, Poland, 33-100
        • Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka
      • Tychy, Poland, 43-100
        • Polsko-Amerykanskie Kliniki Serca
      • Warsaw, Poland, 01-249
        • Balsam Medica
      • Żarów, Poland, 58-130
        • NZOZ Centurm Medyczne SERAFIN-MED
  • Puerto Rico
      • Bayamón, Puerto Rico, 00959
        • Advanced Clinical Research, LLC
      • Ponce, Puerto Rico, 00733
        • Clinical Research Management Group Inc
      • San Juan, Puerto Rico, 00917
        • GCM Medical Group, PSC - Hato Rey Site
  • Romania
      • Baia Mare, Romania, 430222
        • CMI DNBM Dr. Pop Lavinia
      • Baia Mare, Romania, 430124
        • CMI Cardiologie - Dr. Mercea Corina Delia
      • Brasov, Romania, 500283
        • C.M.D.T.A. Neomed
      • Bucharest, Romania, 011053
        • Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
      • Bucharest, Romania, 010507
        • Nicodiab
      • Bucharest, Romania, 013764
        • Centrul Medical NutriLife
      • Bucharest, Romania, 50538
        • Centrul Medical Endocrinologie si Diabet Dr. Paveliu
      • Bucharest, Romania, 020528
        • Lotus-Med Tunari
      • Craiova, Romania, 200642
        • Spitalul Clinic Județean de Urgență
      • Galați, Romania, 800291
        • Diamed Obesity
      • Galați, Romania, 800001
        • Milena Sante
      • Iași, Romania, 700547
        • Centrul Medical Consultmed
      • Iași, Romania, 700687
        • Cardiomed Iași
      • Satu Mare, Romania, 440055
        • Clinica Korall
      • Sibiu, Romania, 550371
        • Policlinica Astra Sibiu
      • Timișoara, Romania, 300288
        • Cabinet Medical Dr.Geru
      • Timișoara, Romania, 300310
        • Institutul de Boli Cardiovasculare Timisoara
      • Timișoara, Romania, 300462
        • Centrul Medical Medicalis
      • Târgu Mureş, Romania, 540142
        • Centrul Medical Mediab
      • Târgu Mureş, Romania, 540098
        • SC Dentosim Queen SRL - Centrul Medical Diamed
      • Târgu Mureş, Romania, 540142
        • Mediab S.R.L.
  • Slovakia
      • Bratislava, Slovakia, 81109
        • Cliniq s.r.o.
      • Dolný Kubín, Slovakia, 02601
        • JM-Interna s.r.o
      • Dolný Kubín, Slovakia, 026 01
        • ENDIAMED s.r.o
      • Lučenec, Slovakia, 984 01
        • IN-DIA
      • Lučenec, Slovakia, 984 01
        • Nemocnica s poliklinikou Lucenec
      • Malacky, Slovakia, 901 01
        • Sin Azucar
      • Martin, Slovakia, 036 01
        • AMBORA s.r.o. Interna ambulancia
      • Nitra, Slovakia, 950 01
        • Fakultna nemocnica Nitra
      • Nové Zámky, Slovakia, 940 02
        • FUNKYSTUFF s.r.o.
      • Námestovo, Slovakia, 02901
        • B-Medical, s.r.o.
      • Piešťany, Slovakia, 921 01
        • MEDIKALS
      • Poltár, Slovakia, 987 01
        • MUDr. Judita Gondova
      • Rimavská Sobota, Slovakia, 979 01
        • ENRIN, s.r.o.
      • Rožňava, Slovakia, 04801
        • Tatratrial s.r.o.
      • Trebišov, Slovakia, 075 01
        • ARETEUS s.r.o.
      • Trstená, Slovakia, 028 01
        • MediPrax, s.r.o.
      • Vrútky, Slovakia, 038 61
        • IRIDIA
      • Ľubochňa, Slovakia, 034 91
        • NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
  • Spain
      • A Coruña, Spain, 15006
        • CHUAC-Complejo Hospitalario Universitario A Coruña
      • Almería, Spain, 04009
        • Centro Periférico de Especialidades Bola Azul
      • Alzira, Spain, 46600
        • Hospital Universitario de La Ribera
      • Barcelona, Spain, 08035
        • Hospital Universitari Vall d'Hebron
      • Ferrol, Spain, 15405
        • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
      • Málaga, Spain, 29010
        • Hospital Universitario Virgen de la Victoria
      • Oviedo, Spain, 33011
        • Hospital Universitario Central de Asturias
      • Palma de Mallorca, Spain, 07014
        • Clínica Juaneda
      • Pozuelo de Alarcón, Spain, 28223
        • Hospital Universitario Quirónsalud Madrid
      • Santander, Spain, 39008
        • Hospital Universitario Marqués de Valdecilla
      • Seville, Spain, 41003
        • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
      • Seville, Spain, 41950
        • Vithas Hospital Sevilla
      • Seville, Spain, 41010
        • Hospital Quiron Infanta Luisa
      • Valencia, Spain, 46017
        • Hospital Universitario Doctor Peset
  • Turkey (Türkiye)
      • Afyonkarahisar, Turkey (Türkiye), 03030
        • Afyon Kocatepe Üniversitesi Tıp Fakültesi
      • Ankara, Turkey (Türkiye), 06800
        • Ankara Bilkent Sehir Hastanesi
      • Ankara, Turkey (Türkiye)
        • Hacettepe Universite Hastaneleri
      • Antalya, Turkey (Türkiye), 07070
        • Akdeniz Universitesi Hastanesi
      • Bornova, Turkey (Türkiye), 35100
        • Ege Universitesi Hastanesi
      • Edirne, Turkey (Türkiye), 22030
        • Trakya University Medical Faculty Hospital
      • Eskişehir, Turkey (Türkiye), 26480
        • Eskisehir Osmangazi University
      • Gaziantep, Turkey (Türkiye), 27310
        • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
      • Istanbul, Turkey (Türkiye), 34865
        • Kartal Kosuyolu Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
      • Istanbul, Turkey (Türkiye), 34668
        • Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
      • Istanbul- Fatih, Turkey (Türkiye), 34098
        • Istanbul Universitesi Cerrahpasa
      • Kayseri, Turkey (Türkiye)
        • Erciyes Universitesi Tıp Fakultesi Hastaneleri
      • Kocaeli, Turkey (Türkiye), 41380
        • Kocaeli Üniversitesi
      • Konya, Turkey (Türkiye), 42080
        • Necmettin Erbakan University Meram Medical Faculty
      • Kütahya, Turkey (Türkiye), 43100
        • T.C. Saglik Bakanligi - Dumlupinar Universitesi Kutahya Evliya Celebi Egitim ve Arastirma Hastanesi
      • Mersin, Turkey (Türkiye), 33343
        • Mersin University
      • Samsun, Turkey (Türkiye), 55270
        • Ondokuz Mayıs Universitesi
      • Sivas, Turkey (Türkiye), 58140
        • Cumhuriyet Universitesi
      • Yıldırım, Turkey (Türkiye), 16310
        • Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi
      • Çorum, Turkey (Türkiye), 19040
        • T.C. Saglik Bakanligi - Hitit Universitesi Corum Egitim ve Arastirma Hastanesi
      • İzmit, Turkey (Türkiye), 41380
        • Kocaeli Üniversitesi
  • Ukraine
      • Chernivtsi, Ukraine, 58000
        • Regional Communal Non-commercial enterprise "Chernivtsi regional clinical hospital"
      • Ivano-Frankivsk, Ukraine, 76018
        • Clinical Diagnostic Center
      • Ivano-Frankivsk, Ukraine, 76005
        • Vise Clinic
      • Kiev, Ukraine, 04114
        • Institute of Endocrinology and Metabolism named after Komissarenko
      • Kyiv, Ukraine, 02002
        • Edelweiss Medics
      • Kyiv, Ukraine, 03037
        • Medbud Clinic
      • Kyiv, Ukraine, 04210
        • Center of Family Medicine Plus
      • Kyiv, Ukraine, 04050
        • ARTEM
      • Kyiv, Ukraine, 03057
        • Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal"
      • Lviv, Ukraine, 79005
        • Lviv City Clinical Hospital #4
      • Lviv, Ukraine, 79010
        • University Hospital of LNMU
      • Vinnytsia, Ukraine, 21009
        • Limited liability company "Medical center Health Clinic"
      • Vinnytsia, Ukraine, 21010
        • Vinnytsia Regional Clinical Endocrinology Dispensary
      • Vinnytsia, Ukraine, 21001
        • Medical center Pulse in Vinnitsi
      • Zhytomyr, Ukraine, 10002
        • Communal Enterprise "Hospital #1" of Zhytomyr City Council
  • United Kingdom
      • Aberdeen, United Kingdom, AB25 2ZN
        • Aberdeen Royal Infirmary
      • Birmingham, United Kingdom, B21 9RY
        • FutureMeds - Birmingham
      • Bromborough, United Kingdom, CH62 6EE
        • FutureMeds - Liverpool
      • Coventry, United Kingdom, CV2 2DX
        • University Hospital Coventry & Warwickshire
      • Glasgow, United Kingdom, G20 7BE
        • FutureMeds Glasgow - CPS Research
      • Hull, United Kingdom, HU3 2JZ
        • Hull Royal Infirmary
      • Ipswich, United Kingdom, IP4 5PD
        • Ipswich Hospital
      • Lancashire, United Kingdom, OL6 6EW
        • Ashton Medical Group - Chapel House
      • London, United Kingdom, E1 1BB
        • Royal London Hospital
      • Londonderry, United Kingdom, BT47 6SB
        • Altnagelvin Area Hospital
      • Newcastle, United Kingdom, NE6 1SG
        • Futuremeds-Newcastle
      • Newquay, United Kingdom, TR7 1RU
        • Newquay Health Centre
      • Redruth, United Kingdom, TR16 4ET
        • Homecroft Surgery
      • Stockton-on-Tees, United Kingdom, TS19 8PE
        • FutureMeds Teesside - Middlefield Centre
      • Swansea, United Kingdom, SA2 8PP
        • Swansea University
      • Taunton, United Kingdom, TA1 5DA
        • Musgrove Park Hospital
      • Torpoint, United Kingdom, PL11 2TB
        • Rame Group Practice
      • West End, United Kingdom, SO30 3JB
        • Moorgreen Hospital
  • United States
    • Alabama
      • Alabaster, Alabama, United States, 35007
        • Alabama Kidney Research
      • Birmingham, Alabama, United States, 35205
        • Central Research Associates
      • Daphne, Alabama, United States, 36526
        • Alliance for Multispecialty Research, LLC
      • Huntsville, Alabama, United States, 35805
        • Nephrology Consultants
      • Mobile, Alabama, United States, 36608
        • Alliance for Multispecialty Research, LLC
    • Arizona
      • Gilbert, Arizona, United States, 85296
        • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
      • Glendale, Arizona, United States, 85304
        • Sun City Clinical Research
      • Glendale, Arizona, United States, 85306
        • Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird
      • Paradise Valley, Arizona, United States, 85253
        • Helios Clinical Research - SAZ-PDV-026
      • Phoenix, Arizona, United States, 85014
        • Phoenix Clinical LLC
      • Phoenix, Arizona, United States, 85006
        • Banner University Medical Center Phoenix
      • Phoenix, Arizona, United States, 85018
        • Elite Clinical Studies, LLC
      • Phoenix, Arizona, United States, 85051
        • Absolute Clinical Research
      • Scottsdale, Arizona, United States, 85260
        • Scottsdale Clinical Trials
      • Sun City West, Arizona, United States, 85375
        • Clinical Research Institute of Arizona (CRI) - Sun City West
      • Tucson, Arizona, United States, 85741
        • Synexus Clinical Research US, Inc./Orange Grove Family Practice
    • Arkansas
      • Little Rock, Arkansas, United States, 72204
        • Cardiology and Medicine Clinic
    • California
      • Apple Valley, California, United States, 92307
        • Kidney & Hypertension Center - Apple Valley
      • Bakersfield, California, United States, 93309
        • Invivo - Bakersfield
      • Beverly Hills, California, United States, 90211
        • American Institute of Research
      • Canoga Park, California, United States, 91303
        • Hope Clinical Research, Inc.
      • Covina, California, United States, 91723
        • Valley Clinical Trials, Inc.
      • Encinitas, California, United States, 92024
        • North Coast Cardiology
      • Escondido, California, United States, 92025
        • Neighborhood Healthcare Institute of Health
      • Fountain Valley, California, United States, 92708
        • HB Clinical Trials - Fountain Valley
      • Huntington Beach, California, United States, 92648
        • Care Access - Huntington Beach
      • Irvine, California, United States, 92614
        • Irvine Clinical Research
      • La Jolla, California, United States, 92037
        • Scripps Whittier Diabetes Institute
      • Long Beach, California, United States, 90815
        • Ark Clinical Research
      • Long Beach, California, United States, 90805
        • Long Beach Research Institute
      • Lynwood, California, United States, 90262
        • North America Research Institute
      • Northridge, California, United States, 91325
        • Valley Clinical Trials, Inc.
      • Palm Springs, California, United States, 92262
        • Desert Oasis Healthcare Medical Group
      • Pasadena, California, United States, 91105
        • California Liver Research Institute
      • Pomona, California, United States, 91766
        • Western University of Health Sciences
      • San Dimas, California, United States, 91773
        • California Kidney Specialists
      • Santa Ana, California, United States, 92701
        • Southern California Clinical Research
      • Santa Clarita, California, United States, 91321
        • Care Access - Santa Clarita
      • Spring Valley, California, United States, 91978
        • Encompass Clinical Research
      • Tarzana, California, United States, 91356
        • Valiance Clinical Research
      • Thousand Oaks, California, United States, 91360
        • Care Access - Thousand Oaks
      • Toluca Lake, California, United States, 91602
        • Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
      • Torrance, California, United States, 90502
        • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
      • Torrance, California, United States, 90505
        • UCLA South Bay Endocrinology
      • Van Nuys, California, United States, 91405
        • InvivoCure
      • Victorville, California, United States, 92392
        • National Institute of Clinical Research (NICR) - High Desert
      • Vista, California, United States, 92083
        • Synexus Clinical Research US, Inc.
      • Westlake Village, California, United States, 91361
        • Millennium Clinical Trials
    • Colorado
      • Arvada, Colorado, United States, 80002
        • Western Nephrology
      • Aurora, Colorado, United States, 80045
        • University of Colorado Anschutz Medical Campus
    • Connecticut
      • Stamford, Connecticut, United States, 06905
        • Cardiology Associates of Fairfield County, P.C.
      • Waterbury, Connecticut, United States, 06708
        • Chase Medical Research, LLC
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Excel Medical Clinical Trials
      • Cutler Bay, Florida, United States, 33157
        • American Research Institute
      • Fleming Island, Florida, United States, 32003
        • Fleming Island Center for Clinical Research
      • Fort Lauderdale, Florida, United States, 33312
        • Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
      • Fort Lauderdale, Florida, United States, 33316
        • Florida Kidney Physicians - Fort Lauderdale
      • Jacksonville, Florida, United States, 32216
        • East Coast Institute for Research, LLC
      • Leesburg, Florida, United States, 34748
        • Lakeview Institute of Clinical Research
      • Miami, Florida, United States, 33186
        • New Age Medical Research Corporation
      • Miami, Florida, United States, 33186
        • Onhealth Research Center
      • Miami, Florida, United States, 33135
        • Flourish Research - Miami, LLC
      • Miami Lakes, Florida, United States, 33014
        • Inpatient Research Clinic
      • Orlando, Florida, United States, 32808
        • Omega Research Orlando
      • Orlando, Florida, United States, 32806
        • CTR Oakwater, LLC
      • Port Charlotte, Florida, United States, 33952
        • Florida Kidney Physicians, LLC
      • Riverview, Florida, United States, 33578
        • Florida Kidney Physicians - Tampa
      • Sarasota, Florida, United States, 34239
        • Cardiovascular Center of Sarasota
      • Tamarac, Florida, United States, 33321
        • Care Access - Tamarac
      • Tampa, Florida, United States, 33625
        • Care Access - Tampa
      • Tampa, Florida, United States, 33607
        • MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research
    • Georgia
      • Acworth, Georgia, United States, 30101
        • American Clinical Trials - Acworth
      • Atlanta, Georgia, United States, 30318
        • Atlanta Diabetes Associates
      • Atlanta, Georgia, United States, 30322
        • Emory University School of Medicine
      • Atlanta, Georgia, United States, 30342
        • Fides Clinical Research
      • Augusta, Georgia, United States, 30904
        • Southeastern Clinical Research Institute
      • Douglasville, Georgia, United States, 30134
        • American Clinical Trials - Douglasville
      • Gainesville, Georgia, United States, 30501
        • Center for Advanced Research & Education
      • Macon, Georgia, United States, 31210
        • The Jones Center Clinical Research
      • Woodstock, Georgia, United States, 30189
        • North Georgia Clinical Research
    • Illinois
      • Chicago, Illinois, United States, 60640
        • Great Lakes Clinical Trials - Ravenswood
      • Gurnee, Illinois, United States, 60031
        • Clinical Investigation Specialists
      • Hinsdale, Illinois, United States, 60521
        • Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale
      • Lombard, Illinois, United States, 60148
        • Accellacare - DuPage
      • Niles, Illinois, United States, 60714
        • Alliance for Multispecialty Research, LLC
      • Rockford, Illinois, United States, 61107
        • Rockford Nephrology Associates
      • Springfield, Illinois, United States, 62711
        • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
    • Indiana
      • Evansville, Indiana, United States, 47715
        • Qualmedica Research, LLC
      • Fort Wayne, Indiana, United States, 46804
        • Nephrology Associates of Northern Illinois and Indiana (NANI) - Fort Wayne
      • Indianapolis, Indiana, United States, 46202
        • Indiana University Health Methodist Hospital
      • Indianapolis, Indiana, United States, 46227
        • Nephrology Associates of Northern Illinois and Indiana - IKS - Indianapolis South
      • Indianapolis, Indiana, United States, 46254
        • Care Access - South Indianapolis
      • Richmond, Indiana, United States, 47374
        • Reid Physician Associates
    • Iowa
      • West Des Moines, Iowa, United States, 50266
        • Iowa Diabetes and Endocrinology Research Center
    • Kansas
      • Fairway, Kansas, United States, 66205
        • The University of Kansas - Clinical Research Center
      • Newton, Kansas, United States, 67114
        • Alliance for Multispecialty Research, LLC
      • Topeka, Kansas, United States, 66606
        • Cotton O'Neil Clinical Research Center
      • Topeka, Kansas, United States, 66606
        • Cotton O'Neil Diabetes & Endocrinology
    • Kentucky
      • Bowling Green, Kentucky, United States, 42101
        • Qualmedica Research
      • Lexington, Kentucky, United States, 40509
        • Alliance for Multispecialty Research, LLC
      • Louisville, Kentucky, United States, 40213
        • L-MARC Research Center
    • Louisiana
      • Lake Charles, Louisiana, United States, 70601
        • Care Access - Lake Charles
      • Monroe, Louisiana, United States, 71201
        • IMA Clinical Research Monroe - Armand
      • New Orleans, Louisiana, United States, 70119
        • Alliance for Multispecialty Research, LLC
    • Maryland
      • Baltimore, Maryland, United States, 21239
        • MedStar Good Samaritan Hospital
      • Baltimore, Maryland, United States, 21209
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, United States, 21213
        • Care Access - Baltimore
      • Baltimore, Maryland, United States, 21229
        • Ascension Saint Agnes Heart Care
      • Beltsville, Maryland, United States, 20705
        • Jadestone Clinical Research
      • Ft. Washington, Maryland, United States, 20744
        • Anderson Medical Research
      • Hyattsville, Maryland, United States, 20782
        • MedStar Health Research Institute (MedStar Physician Based Research Network)
    • Massachusetts
      • Fall River, Massachusetts, United States, 02721
        • NECCR PrimaCare Research
      • Quincy, Massachusetts, United States, 02169
        • Care Access - Quincy
    • Michigan
      • Dearborn, Michigan, United States, 48126
        • Revival Research Institute, LLC
      • Pontiac, Michigan, United States, 48341
        • Elixia MKC, LLC
      • Saint Joseph, Michigan, United States, 49085
        • Lake Michigan Nephrology
      • Southfield, Michigan, United States, 48075
        • Great Lakes Research Institute
      • Troy, Michigan, United States, 48098
        • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
    • Missouri
      • City of Saint Peters, Missouri, United States, 63303
        • StudyMetrix Research
      • Kansas City, Missouri, United States, 64114
        • Alliance for Multispecialty Research, LLC
      • Springfield, Missouri, United States, 65807
        • Clinvest Headlands Llc
    • Montana
      • Butte, Montana, United States, 59701
        • Mercury Street Medical Group, PLLC
      • Missoula, Montana, United States, 59804
        • Boeson Research MSO
    • Nevada
      • Henderson, Nevada, United States, 89052
        • Henderson Clinical Trials
      • Las Vegas, Nevada, United States, 89119
        • Alliance for Multispecialty Research, LLC
      • Las Vegas, Nevada, United States, 89109
        • Excel Clinical Research, LLC
      • Las Vegas, Nevada, United States, 89123
        • Advanced Biomedical Research of America - South Eastern Avenue
      • Las Vegas, Nevada, United States, 89107
        • DaVita Clinical Research - Las Vegas
      • Las Vegas, Nevada, United States, 89128
        • Vector Clinical Trials
    • New York
      • Albany, New York, United States, 12211
        • Capital Cardiology Associates
      • Albany, New York, United States, 12203
        • Albany Medical College, Division of Community Endocrinology
      • Kingston, New York, United States, 12401
        • Westchester Medical Center Advanced Physicians Service
      • New Hyde Park, New York, United States, 11576
        • St. Francis Hospital & Heart Center
      • New York, New York, United States, 10029
        • Icahn School of Medicine at Mount Sinai
      • New York, New York, United States, 10016
        • NYU Langone Health
      • Saratoga Springs, New York, United States, 12866
        • Saratoga Clinical Research
    • North Carolina
      • Fayetteville, North Carolina, United States, 28314
        • Care Access - Fayetteville
      • Greensboro, North Carolina, United States, 27405
        • Medication Management
      • Greenville, North Carolina, United States, 27834
        • Physician's East Endocrinology
      • Lenoir, North Carolina, United States, 28645
        • IMA Clinical Research - Lenoir
      • Morehead City, North Carolina, United States, 28557
        • West Clinical Research
      • Raleigh, North Carolina, United States, 27609
        • Accellacare - Raleigh
      • Wilmington, North Carolina, United States, 28401
        • Accellacare - Wilmington - 1917 Tradd Court
    • Ohio
      • Maumee, Ohio, United States, 43537
        • Advanced Medical Research
    • Oklahoma
      • Norman, Oklahoma, United States, 73069
        • Alliance for Multispecialty Research, LLC
    • Pennsylvania
      • Beaver, Pennsylvania, United States, 15009
        • Heritage Valley Multispecialty Group, Inc
      • Bethlehem, Pennsylvania, United States, 18017
        • Northeast Clinical Research Center
      • Camp Hill, Pennsylvania, United States, 17011
        • Capital Area Research, LLC
      • Danville, Pennsylvania, United States, 17822
        • Geisinger Medical Center
      • Lancaster, Pennsylvania, United States, 17602
        • Lancaster General Hospital
      • Media, Pennsylvania, United States, 19063
        • Clinical Renal Associates Ltd.
      • Philadelphia, Pennsylvania, United States, 19114
        • Clinical Research of Philadelphia
      • Philadelphia, Pennsylvania, United States, 19114
        • Tristar Clinical Investigations
      • Pittsburgh, Pennsylvania, United States, 15243
        • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
      • Sayre, Pennsylvania, United States, 18840
        • Guthrie Medical Group, P.C.
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Medical University of South Carolina
      • Little River, South Carolina, United States, 29566
        • Walker Family Care
      • Mauldin, South Carolina, United States, 29662
        • Care Access - Mauldin
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57104
        • Circle Clinical Research
    • Tennessee
      • Knoxville, Tennessee, United States, 37920
        • Alliance for Multispecialty Research, LLC
      • Memphis, Tennessee, United States, 38119
        • Care Access - Memphis 2
    • Texas
      • Austin, Texas, United States, 78745
        • IMA Clinical Research Austin
      • Brownsville, Texas, United States, 78526
        • Headlands Research - Brownsville
      • Corpus Christi, Texas, United States, 78414
        • Private Practice - Dr. Osvaldo A. Brusco
      • Corpus Christi, Texas, United States, 78404
        • South Texas Clinical Research
      • Dallas, Texas, United States, 75246
        • Renal Disease Research Institute
      • Dallas, Texas, United States, 75231
        • North Texas Endocrine Center
      • Dallas, Texas, United States, 75230
        • Velocity Clinical Research, Dallas
      • Dallas, Texas, United States, 75226
        • Baylor Soltero CV Research Center
      • Dallas, Texas, United States, 75390-9302
        • UT Southwestern Medical Center
      • Denison, Texas, United States, 75020
        • Soma Clinical Trials
      • Edinburg, Texas, United States, 78539
        • South Texas Research Institute
      • El Paso, Texas, United States, 79902-4646
        • Medresearch Inc
      • Fort Worth, Texas, United States, 76132
        • Diabetes and Thyroid Center of Ft. Worth
      • Fort Worth, Texas, United States, 76164
        • Valley Institute of Research - Fort Worth
      • Houston, Texas, United States, 77040
        • Juno Research
      • Houston, Texas, United States, 77043
        • Biopharma Informatic, LLC
      • Houston, Texas, United States, 77074
        • Clinical Trial Network
      • Houston, Texas, United States, 77084
        • Biopharma Informatic, LLC
      • Houston, Texas, United States, 77070
        • Northwest Houston Cardiology - Cypress
      • Houston, Texas, United States, 77079
        • PlanIt Research, PLLC
      • Houston, Texas, United States, 77058
        • Aqua Research Institute
      • Houston, Texas, United States, 77089
        • Research Physicians Network, LLC
      • Humble, Texas, United States, 77346
        • Accurate Clinical Research, Inc
      • Lufkin, Texas, United States, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • McKinney, Texas, United States, 75069
        • Wellness Clinical Research
      • McKinney, Texas, United States, 75071
        • Revival Research Institute, LLC
      • Mesquite, Texas, United States, 75149
        • Southern Endocrinology Associates
      • Mesquite, Texas, United States, 75149
        • Prx Research
      • San Antonio, Texas, United States, 78212
        • Clinical Advancement Center
      • San Antonio, Texas, United States, 78229
        • Ima Clinical Research San Antonio
      • San Antonio, Texas, United States, 78240
        • Endeavor Clinical Trials
      • San Antonio, Texas, United States, 78229
        • Discovery Clinical Trials - San Antonio
      • Shenandoah, Texas, United States, 77384
        • DaVita Clinical Research - North Houston
      • Wylie, Texas, United States, 75098
        • Medrasa Clinical Research
    • Utah
      • Clinton, Utah, United States, 84015
        • Alpine Research Organization
      • Layton, Utah, United States, 84041
        • Alliance for Multispecialty Research, LLC
      • Salt Lake City, Utah, United States, 84115
        • Utah Kidney Research Institute
      • Salt Lake City, Utah, United States, 84106
        • Synexus Clinical Research US, Inc.
    • Virginia
      • Norfolk, Virginia, United States, 23502
        • Alliance for Multispecialty Research, LLC
      • Richmond, Virginia, United States, 23219
        • Dominion Medical Associates, Inc.
    • Washington
      • Redmond, Washington, United States, 98052
        • Eastside Research Associates
      • Tacoma, Washington, United States, 98405
        • Universal Research Group
    • West Virginia
      • Morgantown, West Virginia, United States, 26505
        • IMA Clinical Research West Virginia
    • Wisconsin
      • Green Bay, Wisconsin, United States, 54303
        • St. Vincent Hospital d/b/a Prevea Health
      • Kenosha, Wisconsin, United States, 53144
        • Clinical Investigation Specialists

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Participants may be without type 2 diabetes (T2D), or with T2D if their hemoglobin A1c (HbA1c) is 10% or lower

  • Participants have established atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD), as evidenced at least one of the following:

    • Coronary artery disease
    • Cerebrovascular disease
    • Peripheral arterial disease

    • Chronic kidney disease defined as:

      • eGFR <45 millilitres/minute/1.73 meter squared (mL/min/1.73m^2) and UACR >30 milligram/gram (mg/g) (0.030 mg/mg)
      • eGFR <60 mL/min/1.73 m^2 and UACR >100 mg/g (0.100 mg/mg), or
      • eGFR <75 mL/min/1.73 m^2 and UACR >300 mg/g (0.300 mg/mg) (eGFR is calculated by central lab based on Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin c equation as determined by central lab)
  • A Body Mass Index of ≥27.0 kilograms per meter squared (kg/m^2)

Exclusion Criteria:

Diabetes related:

  • Participants have Type 1 Diabetes or any history of diabetic ketoacidosis

CV related:

  • Participants have any of the following cardiovascular conditions ≤ 90 days prior to randomization:

    • Myocardial infarction
    • Acute coronary syndrome
    • Stroke, or
    • Coronary, peripheral, or carotid artery arterial revascularization procedure.
  • Have acute decompensated heart failure requiring hospitalization.
  • Have New York Heart Association (NYHA) Classification Class IV heart failure at screening

Kidney related:

  • Participants have an eGFR <20 mL/min/1.73 m^2 at screening
  • Have UACR >5000 mg/g (5.000 mg/mg) at screening
  • Have received any form of dialysis ≤ 90 days from the date of randomization
  • Have either undergone a kidney transplant or have a transplant procedure scheduled

Other medical conditions:

  • Participants have had or plan to have a surgical treatment for obesity,
  • Have a history of chronic or acute pancreatitis
  • Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome type 2
  • Have a known clinically significant gastric emptying abnormality, such as severe gastroparesis or gastric outlet obstruction

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Retatrutide
Participants will receive escalated doses of retatrutide administered subcutaneously (SC) up to a maximum tolerated dose.
Drug: Retatrutide
Administered SC
Other Names:
  • LY3437943
Placebo Comparator: Placebo
Participants will receive matching placebo administered SC.
Drug: Placebo
Administered SC

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to First Occurrence of Composite Endpoints
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
A composite endpoint includes nonfatal myocardial infarction (MI), nonfatal stroke, cardiovascular (CV) death, or hospitalization or urgent visit due to heart failure (HF).
Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of Composite Endpoint of End Stage Kidney Disease (ESKD), ≥ 40% Sustained Decline in Estimated Glomerular Filtration Rate (eGFR), CV Death or Renal Death
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)

ESKD is defined as the following individual components: persistent eGFR <15 mL/min/1.73 m^2 confirmed by 2 measurements at least 4 weeks apart at the central laboratory, initiation of dialysis for at least 28 days, receiving a kidney transplant.

Sustained decline in eGFR (≥40%) will be confirmed by a repeated measure at least 4 weeks after the first result.
Randomization up to Study Completion (Approximate 248 Weeks)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Time to First Occurrence of Composite Endpoint of Major Cardiovascular Events (MACE-3)
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
MACE-3 includes CV death, nonfatal MI, and nonfatal stroke.
Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF.
Randomization up to Study Completion (Approximate 248 Weeks)
Time to Occurrence of All-Cause Death
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
Time to all-cause death.
Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of composite endpoint of ≥ 40% Sustained Decline in eGFR, End-Stage Renal Disease (ESRD), or Renal Death
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
Randomization up to Study Completion (Approximate 248 Weeks)
Percentage change from Baseline in Albuminuria urinary albumin/creatinine ratio (UACR) in Participants with UACR ≥30 mg/g (0.03 mg/mg) at baseline
Time Frame: Randomization up to Study Completion (Approximate 248 Weeks)
Randomization up to Study Completion (Approximate 248 Weeks)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 30, 2024

Primary Completion (Estimated)

February 1, 2029

Study Completion (Estimated)

February 1, 2029

Study Registration Dates

First Submitted

April 22, 2024

First Submitted That Met QC Criteria

April 22, 2024

First Posted (Actual)

April 25, 2024

Study Record Updates

Last Update Posted (Actual)

April 20, 2026

Last Update Submitted That Met QC Criteria

April 17, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 18584
  • J1I-MC-GZBO (Other Identifier: Eli Lilly and Company)
  • 2023-508630-34-00 (Other Identifier: EU CTR Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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