A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1% (RELATIVITY1093)

May 19, 2026 updated by: Bristol-Myers Squibb

A Phase 3, Randomized, Open-label Study of Nivolumab + Relatlimab Fixed-dose Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy as First-line Treatment for Participants With Non-squamous (NSQ), Stage IV or Recurrent Non-small Cell Lung Cancer and With Tumor Cell PD-L1 Expression ≥ 1%

The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1000

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: First line of the email MUST contain NCT # and Site #.

Study Contact Backup

  • Name: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
  • Phone Number: 855-907-3286
  • Email: Clinical.Trials@bms.com

Study Locations

  • Argentina
      • Córdoba, Argentina, 5016
        • Recruiting
        • Hospital Privado Universitario De Cordoba
        • Contact:
          • Jeremias Sierra, Site 0215
          • Phone Number: 543514862400
      • Córdoba, Argentina, X5000HWE
        • Recruiting
        • Instituto Oncologico de Cordoba
        • Contact:
          • EDUARDO RICHARDET, Site 0370
          • Phone Number: 351-2325689
      • Mar del Plata, Argentina, 7600
        • Recruiting
        • Hospital Privado De Comunidad
        • Contact:
          • Omar Carranza, Site 0236
          • Phone Number: 5422349900005823
    • Buenos Aires
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
        • Recruiting
        • Instituto Alexander Fleming
        • Contact:
          • Claudio Martin, Site 0217
          • Phone Number: 5491166936669
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 1280
        • Recruiting
        • Hospital Britanico de Buenos Aires
        • Contact:
          • Karina Vera, Site 0379
          • Phone Number: 1121571056
    • Buenos Aires F.D.
      • ABB, Buenos Aires F.D., Argentina, C1199ABB
        • Recruiting
        • Hospital Italiano de Buenos Aires
        • Contact:
          • Lorena Lupinacci, Site 0219
          • Phone Number: 5411495902008159
    • Córdoba Province
      • Río Cuarto, Córdoba Province, Argentina, X5800AEV
        • Recruiting
        • Instituto Médico Río Cuarto
        • Contact:
          • Alejo Lingua, Site 0218
          • Phone Number: 54351153819050
    • Río Negro Province
      • Bariloche, Río Negro Province, Argentina, 8400
        • Not yet recruiting
        • Local Institution - 0493
        • Contact:
          • Site 0493
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000DSV
        • Recruiting
        • Sanatorio Parque
        • Contact:
          • Gaston Martinengo, Site 0216
          • Phone Number: 5493416955611
  • Australia
    • New South Wales
      • Gosford, New South Wales, Australia, 2250
        • Recruiting
        • Gosford Hospital
        • Contact:
          • Matthew Chan, Site 0058
          • Phone Number: +61243209890
      • St Leonards, New South Wales, Australia, 2065
        • Recruiting
        • GenesisCare North Shore
        • Contact:
          • Nick Pavlakis, Site 0061
          • Phone Number: 61294631172
    • Queensland
      • Brisbane, Queensland, Australia, 4032
        • Recruiting
        • The Prince Charles Hospital
        • Contact:
          • Brett Hughes, Site 0243
          • Phone Number: 61736468111
      • Brisbane, Queensland, Australia, 4120
        • Recruiting
        • Gallipoli Medical Research Ltd
        • Contact:
          • Kenneth O'Byrne, Site 0068
          • Phone Number: 0731766505
    • South Australia
      • Elizabeth Vale, South Australia, Australia, 5112
        • Not yet recruiting
        • Local Institution - 0057
        • Contact:
          • Site 0057
    • Victoria
      • Box Hill, Victoria, Australia, 3128
        • Recruiting
        • Box Hill Hospital
        • Contact:
          • Andrew Mant, Site 0054
          • Phone Number: 61398953281
    • Western Australia
      • Murdoch, Western Australia, Australia, 6150
        • Recruiting
        • Fiona Stanley Hospital
        • Contact:
          • Lydia Warburton, Site 0053
          • Phone Number: 0000000000
      • Murdoch, Western Australia, Australia, 6150
        • Recruiting
        • St. John of God Murdoch Hospital
        • Contact:
          • Kynan Feeney, Site 0056
          • Phone Number: +61894389599
  • Austria
      • Vienna, Austria, 1210
        • Recruiting
        • Klinik Floridsdorf
        • Contact:
          • Maximilian Hochmair, Site 0293
          • Phone Number: +4319106041242
    • Lower Austria
      • Krems, Lower Austria, Austria, 3500
        • Recruiting
        • Universitätsklinikum Krems
        • Contact:
          • Klaus Hackner, Site 0314
          • Phone Number: 0273290044368
    • Upper Austria
      • Wels, Upper Austria, Austria, 4600
        • Recruiting
        • Klinikum Wels-Grieskirchen GmbH
        • Contact:
          • Christian Trockenbacher, Site 0292
          • Phone Number: 4372424152382
  • Belgium
      • Liège, Belgium, 4000
        • Recruiting
        • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
        • Contact:
          • Pierre FRERES, Site 0185
          • Phone Number: 003243237801
    • Antwerpen
      • Edegem, Antwerpen, Belgium, 2650
        • Recruiting
        • Antwerp University Hospital
        • Contact:
          • Reinier Wener, Site 0396
          • Phone Number: 038215180
    • Bruxelles-Capitale, Région de
      • Brussels, Bruxelles-Capitale, Région de, Belgium, 1090
        • Recruiting
        • UZ Brussel
        • Contact:
          • Lore Decoster, Site 0039
          • Phone Number: 3224775457
    • Limburg
      • Hasselt, Limburg, Belgium, 3500
        • Recruiting
        • Jessa Ziekenhuis
        • Contact:
          • Kristof Cuppens, Site 0187
          • Phone Number: +32472565987
    • Namur
      • Yvoir, Namur, Belgium, 5530
        • Recruiting
        • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
        • Contact:
          • Sebahat Ocak, Site 0038
          • Phone Number: 3281423351
    • West-Vlaanderen
      • Roeselare, West-Vlaanderen, Belgium, 8800
        • Recruiting
        • AZ Delta vzw
        • Contact:
          • Ingel Demedts, Site 0041
          • Phone Number: 3251237216
  • Brazil
      • Rio de Janeiro, Brazil, 20231-050
        • Recruiting
        • Instituto Nacional de Câncer - INCA
        • Contact:
          • Luiz Henrique Araujo, Site 0232
          • Phone Number: 552132076585
      • São Paulo, Brazil, 01246-000
        • Recruiting
        • Icesp - Instituto Do Câncer Do Estado de São Paulo
        • Contact:
          • Milena Perez Mak, Site 0147
          • Phone Number: 551138932632
      • São Paulo, Brazil, 01323001
        • Not yet recruiting
        • Local Institution - 0496
        • Contact:
          • Site 0496
    • Ceará
      • Fortaleza, Ceará, Brazil, 60810180
        • Recruiting
        • Pronutrir
        • Contact:
          • Herbert Tavares Palmeira, Site 0382
          • Phone Number: 558532865934
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30110-022
        • Recruiting
        • Cetus Oncologia - Unidade Belo Horizonte
        • Contact:
          • Elisa Ramos, Site 0078
          • Phone Number: 5531998619660
    • Pará
      • Belém, Pará, Brazil, 66063-495
        • Recruiting
        • CTO - Centro de Tratamento Oncológico
        • Contact:
          • Bruno Fernandes, Site 0375
          • Phone Number: 91999809897
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, Brazil, 59075-740
        • Recruiting
        • Liga Norte Riograndense contra o cancer
        • Contact:
          • Joilda Rego, Site 0151
          • Phone Number: 558440095595
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Recruiting
        • Hospital de Clinicas de Porto Alegre
        • Contact:
          • Rodrigo Pereira, Site 0083
          • Phone Number: 5551999734670
      • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
        • Recruiting
        • Hospital Sao Lucas da PUCRS
        • Contact:
          • Ana Caroline Gelatti, Site 0076
          • Phone Number: (51)3320-3039
    • Santa Catarina
      • Itajaí, Santa Catarina, Brazil, 88301-220
        • Recruiting
        • Clínica de Neoplasias Litoral
        • Contact:
          • Giuliano Borges, Site 0084
          • Phone Number: 5547984046243
      • Timbó, Santa Catarina, Brazil, 89120000
        • Not yet recruiting
        • Local Institution - 0501
        • Contact:
          • Site 0501
    • São Paulo
      • Barretos, São Paulo, Brazil, 14784400
        • Recruiting
        • Fundação Pio XII - Hospital de Câncer de Barretos
        • Contact:
          • Josiane Dias, Site 0152
          • Phone Number: 17996782301
      • Bauru, São Paulo, Brazil, 17033-490
        • Recruiting
        • NAIC - Instituto do Câncer
        • Contact:
          • Marcelo Antunes, Site 0149
          • Phone Number: +5514997923873
      • São Caetano do Sul, São Paulo, Brazil, 09541-270
        • Recruiting
        • Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
        • Contact:
          • Daniel Cubero, Site 0373
          • Phone Number: 551199964-2770
      • Taubaté, São Paulo, Brazil, 12030-200
        • Not yet recruiting
        • Local Institution - 0497
        • Contact:
          • Site 0497
  • Canada
    • Quebec
      • Montreal, Quebec, Canada, J4B6S4
        • Not yet recruiting
        • Local Institution - 0494
        • Contact:
          • Site 0494
  • Chile
    • Los Ríos Region
      • Valdivia, Los Ríos Region, Chile, 5090000
        • Not yet recruiting
        • Local Institution - 0492
        • Contact:
          • Site 0492
    • Santiago Metropolitan
      • Santiago, Santiago Metropolitan, Chile, 7500921
        • Recruiting
        • Fundación Arturo López Perez (FALP)
        • Contact:
          • Christian Caglevic, Site 0249
          • Phone Number: 56224457254
      • Santiago, Santiago Metropolitan, Chile, 8420383
        • Recruiting
        • Bradfordhill
        • Contact:
          • Carlos Rojas, Site 0214
          • Phone Number: +56998744662
      • Santiago, Santiago Metropolitan, Chile, 8330032
        • Recruiting
        • Pontificia Universidad Catolica de Chile
        • Contact:
          • Hector Galindo, Site 0212
          • Phone Number: +56963413803
      • Santiago, Santiago Metropolitan, Chile
        • Recruiting
        • Orlandi Oncología
        • Contact:
          • Francisco Orlandi, Site 0213
          • Phone Number: 56992214787
    • Valparaiso
      • Viña del Mar, Valparaiso, Chile, 2520598
        • Recruiting
        • Oncocentro Apys
        • Contact:
          • Alejandro Acevedo Gaete, Site 0452
          • Phone Number: +56992369820
    • Vitacura
      • Santiago, Vitacura, Chile, '7650018
        • Not yet recruiting
        • Local Institution - 0495
        • Contact:
          • Site 0495
  • China
      • Guangzhou, China, 510120
        • Recruiting
        • Guangdong Provincial People's Hospital
        • Contact:
          • Chongrui Xu, Site 0307
          • Phone Number: 86208382781250815
    • Anhui
      • Hefei, Anhui, China, 230031
        • Not yet recruiting
        • Local Institution - 0182
        • Contact:
          • Site 0182
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer Hospital
        • Contact:
          • Jian Fang, Site 0070
          • Phone Number: 861088196479
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400030
        • Recruiting
        • Chongqing University Cancer Hospital
        • Contact:
          • Chunmei Wang, Site 0238
          • Phone Number: 8615111954802
      • Wanzhou, Chongqing Municipality, China, 404000
        • Recruiting
        • Chongqing Three Gorges Central Hospital
        • Contact:
          • Wei Wang, Site 0244
          • Phone Number: 8613635324483
    • Fujian
      • Fuzhou, Fujian, China, 350014
        • Recruiting
        • Fujian Cancer Hospital
        • Contact:
          • Haipeng Xu, Site 0075
          • Phone Number: 8613675007687
    • Guangdong
      • Guangzhou, Guangdong, China, 510080
        • Recruiting
        • The First Affiliated Hospital, Sun Yat-sen University
        • Contact:
          • Kejing Tang, Site 0098
          • Phone Number: 8613802946566
      • Guangzhou, Guangdong, China, 510140
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University
        • Contact:
          • Haihong Yang, Site 0067
          • Phone Number: 13711244230
      • Huizhou, Guangdong, China, 516001
        • Recruiting
        • Huizhou Central People's Hospital
        • Contact:
          • Ying He, Site 0326
          • Phone Number: 13928311788
    • Guangxi
      • Liuzhou, Guangxi, China, 545006
        • Recruiting
        • Liuzhou People's Hospital
        • Contact:
          • Jingzhang Li, Site 0353
          • Phone Number: 18078259868
      • Nanning, Guangxi, China, 530201
        • Recruiting
        • Guangxi Medical University Affiliated Tumor Hospital
        • Contact:
          • Qitao Yu, Site 0134
          • Phone Number: 13878106696
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150081
        • Recruiting
        • Harbin Medical University Cancer Hospital
        • Contact:
          • Yan Yu, Site 0102
          • Phone Number: 13904505825
    • Henan
      • Xinxiang, Henan, China, 453100
        • Recruiting
        • The First Affiliated Hospital of Xinxiang Medical University
        • Contact:
          • Yinghua Ji, Site 0420
          • Phone Number: 13663030446
      • Zhengzhou, Henan, China, 450000
        • Completed
        • Local Institution - 0237
    • Hubei
      • Wuhan, Hubei, China, 430079
        • Withdrawn
        • Local Institution - 0235
    • Hunan
      • Changsha, Hunan, China, 410013
        • Recruiting
        • Hunan Cancer Hospital
        • Contact:
          • Lin Wu, Site 0072
          • Phone Number: 8613170419973
    • Jiangsu
      • Huai'an, Jiangsu, China, 223300
        • Recruiting
        • First Huai'an Hospital Affiliated to Nanjing Medical University
        • Contact:
          • Zili Meng, Site 0354
          • Phone Number: 13952399232
    • Jiangxi
      • Nanchang, Jiangxi, China, 330209
        • Recruiting
        • The First affiliated hospital of Nanchang University (Xianghu campus)
        • Contact:
          • Longhua Sun, Site 0451
          • Phone Number: 8613698091288
    • Liaoning
      • Shenyang, Liaoning, China, 110042
        • Recruiting
        • Liaoning Cancer Hospital
        • Contact:
          • Rui Ma, Site 0181
          • Phone Number: 13304006343
    • Shaanxi
      • Xi'an, Shaanxi, China, 710126
        • Recruiting
        • Xi'an International Medical Center Hospital
        • Contact:
          • Kejun Nan, Site 0423
          • Phone Number: 8613319286228
    • Shandong
      • Jinan, Shandong, China, 250117
        • Recruiting
        • Shandong Cancer Hospital
        • Contact:
          • Ligang Xing, Site 0074
          • Phone Number: 86-15553181309
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200030
        • Recruiting
        • Shanghai Chest Hospital
        • Contact:
          • Hua Zhong, Site 0280
          • Phone Number: 13818200560
      • Shanghai, Shanghai Municipality, China, 200032
        • Recruiting
        • Zhongshan Hospital,Fudan University
        • Contact:
          • Yong Zhang, Site 0318
          • Phone Number: 15000229853
    • Shanxi
      • Taiyuan, Shanxi, China, 030000
        • Recruiting
        • Shanxi Cancer Hospital
        • Contact:
          • wei guo, Site 0435
          • Phone Number: 13834563396
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • Sichuan Cancer Hospital
        • Contact:
          • Juan Li, Site 0121
          • Phone Number: +8613880276636
      • Neijiang, Sichuan, China, 641000
        • Recruiting
        • The Second People's Hospital of Neijiang
        • Contact:
          • Yu Liu, Site 0424
          • Phone Number: +8613698308655
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300060
        • Recruiting
        • Tianjin Medical University Cancer Institute & Hospital
        • Contact:
          • Peng Chen, Site 0177
          • Phone Number: 022-23340123
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital
        • Contact:
          • Xinmin Yu, Site 0338
          • Phone Number: 8613705718617
      • Hangzhou, Zhejiang, China, 310003
        • Recruiting
        • The First Affiliated Hospital, Zhejiang University School of Medicine
        • Contact:
          • Jianya Zhou, Site 0071
          • Phone Number: 8613858123060
      • Hangzhou, Zhejiang, China, 310016
        • Recruiting
        • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
        • Contact:
          • Enguo Chen, Site 0099
          • Phone Number: 13588706779
      • Linhai, Zhejiang, China, 317000
        • Recruiting
        • Taizhou Hospital of Zhejiang Province
        • Contact:
          • Dongqing LV, Site 0101
          • Phone Number: 13867622009
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia
        • Recruiting
        • Instituto de Cancerología
        • Contact:
          • Diego Gonzalez, Site 0415
          • Phone Number: 573206912418
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 110131
        • Not yet recruiting
        • Local Institution - 0418
        • Contact:
          • Site 0418
      • Bogotá, Bogota D.C., Colombia
        • Recruiting
        • Hospital Universitario San Ignacio
        • Contact:
          • July Russi Noguera, Site 0443
          • Phone Number: 575946161x2473
    • Cesar Department
      • Valledupar, Cesar Department, Colombia, 200001
        • Not yet recruiting
        • Local Institution - 0417
        • Contact:
          • Site 0417
    • Risaralda Department
      • Pereira, Risaralda Department, Colombia, 660001
        • Recruiting
        • Oncologos del Occidente
        • Contact:
          • Gustavo Rojas-Uribe, Site 0416
          • Phone Number: 573155313926
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Not yet recruiting
        • Local Institution - 0442
        • Contact:
          • Site 0442
  • Denmark
    • Capital Region
      • Copenhagen, Capital Region, Denmark, 2100
        • Recruiting
        • Rigshospitalet
        • Contact:
          • Steen de Blanck, Site 0125
          • Phone Number: 22996612
    • Central Jutland
      • Aarhus, Central Jutland, Denmark, 8200
        • Recruiting
        • Aarhus Universitetshospital, Skejby
        • Contact:
          • Pernille Elming, Site 0198
          • Phone Number: +4524925948
    • Region Syddanmark
      • Sønderborg, Region Syddanmark, Denmark, 6400
        • Recruiting
        • Sygehus Soenderjylland
        • Contact:
          • Daniela Zitnjak, Site 0124
          • Phone Number: 79973114
  • France
      • Bayonne, France, 64109
        • Recruiting
        • Centre Hospitalier de la Cote Basque
        • Contact:
          • Sophie Schneider, Site 0421
          • Phone Number: 0559443885
      • Bordeaux, France, 33076
        • Not yet recruiting
        • Local Institution - 0470
        • Contact:
          • Site 0470
      • Marseille, France, 13915
        • Recruiting
        • Assistance Publique Hôpitaux de Marseille - Hôpital Nord
        • Contact:
          • Laurent Greillier, Site 0158
          • Phone Number: 33491324400
      • Paris, France, 75248
        • Recruiting
        • Institut Curie
        • Contact:
          • nicolas girard, Site 0095
          • Phone Number: +33624456290
      • Paris, France, 75014
        • Recruiting
        • Hopitaux Universitaires Paris Centre-Hopital Cochin
        • Contact:
          • Marie Wislez, Site 0089
          • Phone Number: 33158413091
    • Bourgogne-Franche-Comté
      • Dijon, Bourgogne-Franche-Comté, France, 21000
        • Not yet recruiting
        • Local Institution - 0475
        • Contact:
          • Site 0475
    • Finistère
      • Brest, Finistère, France, 29200
        • Recruiting
        • CHRU de Brest
        • Contact:
          • Gilles Quere, Site 0462
          • Phone Number: 33298223578
    • Haute-Garonne
      • Toulouse, Haute-Garonne, France, 31059
        • Recruiting
        • CHU de Toulouse - Hôpital Larrey
        • Contact:
          • Julien Mazieres, Site 0090
          • Phone Number: 33567771837
    • Hérault
      • Montpellier, Hérault, France, 34298
        • Withdrawn
        • Local Institution - 0092
    • Ille-et-Vilaine
      • Rennes, Ille-et-Vilaine, France, 35033
        • Withdrawn
        • Local Institution - 0093
    • Meurthe-et-Moselle
      • Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France, 54511
        • Recruiting
        • Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
        • Contact:
          • Bertrand Mennecier, Site 0395
          • Phone Number: 33383154653
    • Nord
      • Lille, Nord, France, 59037
        • Recruiting
        • CHU Lille - Institut Coeur Poumon
        • Contact:
          • Arnaud Scherpereel, Site 0096
          • Phone Number: 33320444998
    • Provence-Alpes-Côte d'Azur Region
      • Toulon, Provence-Alpes-Côte d'Azur Region, France, 83100
        • Recruiting
        • Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
        • Contact:
          • Clarisse Audigier-Valette, Site 0091
          • Phone Number: 33494145610
    • Rhône
      • Pierre-Bénite, Rhône, France, 69310
        • Recruiting
        • Centre Hospitalier Lyon Sud
        • Contact:
          • Sebastien Couraud, Site 0157
          • Phone Number: 33478865924
    • Vaucluse
      • Avignon, Vaucluse, France, 84918
        • Not yet recruiting
        • Local Institution - 0471
        • Contact:
          • Site 0471
  • Germany
      • Berlin, Germany, 13353
        • Recruiting
        • Charité Campus Virchow-Klinikum
        • Contact:
          • Nikolaj Frost, Site 0285
          • Phone Number: 004930450553044
      • Bonn, Germany, 53127
        • Recruiting
        • Universitätsklinikum Bonn
        • Contact:
          • Peter Brossart, Site 0282
          • Phone Number: 4922828722234
      • Essen, Germany, 45122
        • Recruiting
        • Universitaetsklinikum Essen
        • Contact:
          • Marcel Wiesweg, Site 0288
          • Phone Number: 020172385032
      • Gauting, Germany, 82131
        • Recruiting
        • Asklepios Klinik Gauting GmbH
        • Contact:
          • Niels Reinmuth, Site 0286
          • Phone Number: 004989857914001
    • Baden-Wurttemberg
      • Esslingen am Neckar, Baden-Wurttemberg, Germany, 73730
        • Recruiting
        • Klinikum Esslingen
        • Contact:
          • Martin Faehling, Site 0284
          • Phone Number: +4971131032402
      • Ulm, Baden-Wurttemberg, Germany, 89081
        • Recruiting
        • Bundeswehrkrankenhaus Ulm
        • Contact:
          • Matthias Mueller, Site 0439
          • Phone Number: +490731171031253
    • Bavaria
      • Kempten (Allgäu), Bavaria, Germany, 87439
        • Recruiting
        • Klinikverbund Allgaeu
        • Contact:
          • Christian Schumann, Site 0287
          • Phone Number: +4983239108171
      • München, Bavaria, Germany, 81377
        • Recruiting
        • Klinikum der Ludwig-Maximilians-Universitaet Muenchen
        • Contact:
          • Diego Kauffmann-Guerrero, Site 0347
          • Phone Number: 4989440052590
    • Hesse
      • Marburg, Hesse, Germany, 35033
        • Recruiting
        • Universitätsklinikum Marburg
        • Contact:
          • Charis Faoro, Site 0313
          • Phone Number: 4964215862784
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30161
        • Recruiting
        • Praxis Onkologie am Raschplatz
        • Contact:
          • Eyck von der Heyde, Site 0436
          • Phone Number: 0177-6506614
    • North Rhine-Westphalia
      • Dortmund, North Rhine-Westphalia, Germany, 44263
        • Not yet recruiting
        • Local Institution - 0469
        • Contact:
          • Site 0469
      • Herne, North Rhine-Westphalia, Germany, 44651
        • Recruiting
        • Evangelisches Krankenhaus Herne - Eickel
        • Contact:
          • Daniel Christoph, Site 0397
          • Phone Number: +49232349892793
      • Münster, North Rhine-Westphalia, Germany, 48149
        • Recruiting
        • Universitätsklinikum Münster - Albert Schweitzer Campus
        • Contact:
          • Annalen Bleckmann, Site 0438
          • Phone Number: 492518352712
    • Saxony
      • Chemnitz, Saxony, Germany, 09116
        • Recruiting
        • Klinikum Chemnitz
        • Contact:
          • Stefan Hammerschmidt, Site 0437
          • Phone Number: 4937133343550
    • Schleswig-Holstein
      • Großhansdorf, Schleswig-Holstein, Germany, 22927
        • Recruiting
        • LungenClinic Grosshansdorf
        • Contact:
          • Martin Reck, Site 0316
          • Phone Number: 041026012101
      • Lübeck, Schleswig-Holstein, Germany, 23538
        • Not yet recruiting
        • Local Institution - 0466
        • Contact:
          • Site 0466
  • India
    • Haryana
      • Badsa, Haryana, India, 124105
        • Not yet recruiting
        • Local Institution - 0474
        • Contact:
          • Site 0474
    • Karnataka
      • Bengaluru, Karnataka, India, 560017
        • Recruiting
        • Manipal Hospitals
        • Contact:
          • Amit Rauthan, Site 0333
          • Phone Number: 918025023407
    • Kerala
      • Thiruvananthapuram, Kerala, India, 695011
        • Recruiting
        • Regional Cancer Centre - Thiruvananthapuram
        • Contact:
          • Anoop Manoharan, Site 0331
          • Phone Number: 04712522653
    • Maharashtra
      • Mumbai, Maharashtra, India, 400012
        • Recruiting
        • Tata Memorial Hospital
        • Contact:
          • Kumar Prabhash, Site 0336
          • Phone Number: 9167760576
      • Mumbai, Maharashtra, India, 400 057
        • Recruiting
        • Mumbai Oncocare Centre Vile Parle
        • Contact:
          • Ashish Joshi, Site 0446
          • Phone Number: 9619597946
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Recruiting
        • All India Institute of Medical Sciences
        • Contact:
          • Prabhat Malik, Site 0329
          • Phone Number: 911129575232
      • New Delhi, National Capital Territory of Delhi, India, 110085
        • Recruiting
        • Rajiv Gandhi Cancer Institute And Research Centre
        • Contact:
          • Ullas Batra, Site 0337
          • Phone Number: 919711080001
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Not yet recruiting
        • Local Institution - 0448
        • Contact:
          • Site 0448
    • Telangana
      • Secunderabad, Telangana, India, 500003
        • Recruiting
        • Yashoda Hospital
        • Contact:
          • Bharat Ashok Vaswani, Site 0453
          • Phone Number: 040-67778999
    • Uttar Pradesh
      • Varanasi, Uttar Pradesh, India, 221005
        • Not yet recruiting
        • Local Institution - 0476
        • Contact:
          • Site 0476
    • West Bengal
      • Howrah, West Bengal, India, 711103
        • Recruiting
        • Narayana Superspecialty Hospital
        • Contact:
          • Chandrakanth MV, Site 0328
          • Phone Number: 7738519198
  • Ireland
      • Dublin, Ireland, D24 NR0A
        • Recruiting
        • Tallaght University Hospital
        • Contact:
          • Sebastian Trainor, Site 0029
          • Phone Number: 0035314144299
      • Dublin, Ireland, D08 E9P6
        • Recruiting
        • St. James's Hospital
        • Contact:
          • Sinead Cuffe, Site 0367
          • Phone Number: 35314103756
      • Dublin, Ireland, D18 AK68
        • Recruiting
        • Beacon Hospital
        • Contact:
          • Lisa Prior, Site 0028
          • Phone Number: +35312935666
      • Dublin, Ireland, D9
        • Withdrawn
        • Local Institution - 0027
  • Italy
      • Bergamo, Italy, 24125
        • Not yet recruiting
        • Local Institution - 0482
        • Contact:
          • Site 0482
      • Florence, Italy, 50134
        • Not yet recruiting
        • Local Institution - 0478
        • Contact:
          • Site 0478
      • Palermo, Italy, 90127
        • Not yet recruiting
        • Local Institution - 0479
        • Contact:
          • Site 0479
      • Ravenna, Italy, 48121
        • Withdrawn
        • Local Institution - 0222
      • Rome, Italy, 152
        • Not yet recruiting
        • Local Institution - 0481
        • Contact:
          • Site 0481
      • Siena, Italy, 53100
        • Not yet recruiting
        • Local Institution - 0480
        • Contact:
          • Site 0480
    • Apulia
      • Bari, Apulia, Italy, 70124
        • Recruiting
        • Instituto Tumori Giovanni Paolo II
        • Contact:
          • Domenico Galetta, Site 0043
          • Phone Number: 390805555442
    • Emilia-Romagna
      • Ravenna, Emilia-Romagna, Italy, 48121
        • Recruiting
        • Ospedale Santa Maria delle Croci
        • Contact:
          • Manolo D Arcangelo, Site 0400
          • Phone Number: 390544285330
    • Lombardy
      • Monza, Lombardy, Italy, 20900
        • Not yet recruiting
        • Local Institution - 0045
        • Contact:
          • Site 0045
    • Milano
      • Milan, Milano, Italy, 20162
        • Not yet recruiting
        • Local Institution - 0465
        • Contact:
          • Site 0465
    • Napoli
      • Naples, Napoli, Italy, 80131
        • Recruiting
        • A.O.R.N. Ospedale dei Colli - Monaldi V.
        • Contact:
          • Danilo Rocco, Site 0046
          • Phone Number: 390817064300
      • Naples, Napoli, Italy, 80131
        • Recruiting
        • Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli
        • Contact:
          • Ferdinando Riccardi, Site 0049
          • Phone Number: +39817472223
    • Roma
      • Rome, Roma, Italy, 00144
        • Recruiting
        • Istituto Nazionale Tumori Regina Elena
        • Contact:
          • Gabriele Minuti, Site 0250
          • Phone Number: 3485821765
    • Verona
      • Peschiera del Garda, Verona, Italy, 37019
        • Recruiting
        • Casa di Cura Dott. Pederzoli
        • Contact:
          • ANTONIO SANTO, Site 0221
          • Phone Number: 0456444843
  • Japan
      • Akashi, Japan, 6738558
        • Recruiting
        • Hyogo Cancer Center
        • Contact:
          • Yoshihiro Hattori, Site 0327
          • Phone Number: 81789291151
      • Fukushima, Japan, 960-1295
        • Recruiting
        • Fukushima Medical University
        • Contact:
          • Naoyuki Okabe, Site 0319
          • Phone Number: 81245471111
      • Osaka, Japan, 541-8567
        • Recruiting
        • Osaka International Cancer Institute
        • Contact:
          • Kazumi Nishino, Site 0340
          • Phone Number: 81669721181
    • Chiba
      • Kashiwa, Chiba, Japan, 277-8577
        • Recruiting
        • National Cancer Center Hospital East
        • Contact:
          • Yu Tanaka, Site 0312
          • Phone Number: 81471331111
    • Fukuoka
      • Kitakyushu, Fukuoka, Japan, 807-8556
        • Recruiting
        • University Of Occupational And Environmental Health Hospital
        • Contact:
          • Masaru Takenaka, Site 0320
          • Phone Number: 0936031611
      • Kurume, Fukuoka, Japan, 830-0011
        • Recruiting
        • Kurume University Hospital
        • Contact:
          • Koichi Azuma, Site 0273
          • Phone Number: 81942317629
    • Hiroshima
      • Fukuyama-shi, Hiroshima, Japan, 720-0001
        • Recruiting
        • Chugoku Central Hospital
        • Contact:
          • Kenichi Gemba, Site 0276
          • Phone Number: +81849849702121
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 003-0804
        • Recruiting
        • National Hospital Organization Hokkaido Cancer Center
        • Contact:
          • Satoshi Oizumi, Site 0311
          • Phone Number: +81118119111
    • Kanagawa
      • Yokohama, Kanagawa, Japan, 236-0051
        • Recruiting
        • Kanagawa Cardiovascular and Respiratory Center
        • Contact:
          • Tomohisa Baba, Site 0449
          • Phone Number: 81457019581
      • Yokohama, Kanagawa, Japan, 2418515
        • Recruiting
        • Kanagawa Cancer Center
        • Contact:
          • Haruhiro Saito, Site 0321
          • Phone Number: 81455202222
    • Kochi
      • Nankoku, Kochi, Japan, 783-8505
        • Recruiting
        • Kochi Medical School Hospital
        • Contact:
          • TOSHIYUKI KOZUKI, Site 0444
          • Phone Number: +81888665811
    • Miyagi
      • Sendai, Miyagi, Japan, 9810914
        • Recruiting
        • Sendai Kousei Hospital
        • Contact:
          • Shunichi Sugawara, Site 0339
          • Phone Number: 81227288000
    • Nara
      • Kashihara, Nara, Japan, 634-0813
        • Recruiting
        • Nara Medical University Hospital
        • Contact:
          • Masayuki Takeda, Site 0322
          • Phone Number: 81744223051
    • Niigata
      • Niigata, Niigata, Japan, 951-8566
        • Recruiting
        • Niigata Cancer Center Hospital
        • Contact:
          • Hiroshi Tanaka, Site 0279
          • Phone Number: 81252665111
    • Okayama-ken
      • Kurashiki, Okayama-ken, Japan, 710-8602
        • Recruiting
        • Kurashiki Central Hospital
        • Contact:
          • Toshihide Yokoyama, Site 0306
          • Phone Number: 81864220210
    • Osaka
      • Hirakata, Osaka, Japan, 573-1191
        • Recruiting
        • Kansai Medical University Hospital
        • Contact:
          • Takayasu Kurata, Site 0275
          • Phone Number: 81728042503
      • Sakai, Osaka, Japan, 590-0197
        • Recruiting
        • Kindai University Hospital
        • Contact:
          • Hidetoshi Hayashi, Site 0277
          • Phone Number: 81723681184
    • Saitama
      • Hidaka, Saitama, Japan, 350-1298
        • Recruiting
        • Saitama Medical University International Medical Center
        • Contact:
          • Hiroshi Kagamu, Site 0274
          • Phone Number: 819014217189
    • Shizuoka
      • Hamamatsu, Shizuoka, Japan, 431-3192
        • Recruiting
        • Hamamatsu University Hospital
        • Contact:
          • Naoki Inui, Site 0278
          • Phone Number: 81534352356
      • Nagaizumi-cho,Sunto-gun, Shizuoka, Japan, 411-8777
        • Recruiting
        • Shizuoka Cancer Center
        • Contact:
          • Hirotsugu Kenmotsu, Site 0310
          • Phone Number: 81559895222
    • Tokyo
      • Koto, Tokyo, Japan, 135-8550
        • Recruiting
        • The Cancer Institute Hospital of JFCR
        • Contact:
          • Ken Uchibori, Site 0323
          • Phone Number: 81335200111
  • Mexico
      • México, Mexico, 06700
        • Recruiting
        • Arke SMO S.A. de C.V.
        • Contact:
          • Eleazar Macedo Perez, Site 0172
          • Phone Number: 525533345856
      • Querétaro, Mexico, 76000
        • Recruiting
        • Hospital H+ Queretaro
        • Contact:
          • Juan Feregrino, Site 0168
          • Phone Number: +524421145730
      • San Luis Potosí City, Mexico, 78250
        • Recruiting
        • Centro Potosino de Investigación Médica
        • Contact:
          • Pedro Figueroa Martinez, Site 0169
          • Phone Number: 4444479873
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44260
        • Recruiting
        • Cancer Treamtent Clinic and Clinical Trials Sa de Cv
        • Contact:
          • Juan Vazquez Limon, Site 0170
          • Phone Number: 523316063096
  • Netherlands
      • Arnhem, Netherlands, 6815 AD
        • Recruiting
        • Ziekenhuis Rijnstate
        • Contact:
          • Niels Claessens, Site 0033
          • Phone Number: 31880056730
      • Groningen, Netherlands, 9700 RB
        • Withdrawn
        • Local Institution - 0032
    • Gelderland
      • Harderwijk, Gelderland, Netherlands, 3844 DG
        • Withdrawn
        • Local Institution - 0030
    • Limburg
      • Heerlen, Limburg, Netherlands, 6419 PC
        • Recruiting
        • Atrium-Orbis - Zuyderland Medisch Centrum Heerlen
        • Contact:
          • Frank Custers, Site 0193
          • Phone Number: 31884597777
    • North Brabant
      • 's-Hertogenbosch, North Brabant, Netherlands, 5223 GZ
        • Withdrawn
        • Local Institution - 0196
    • Overijssel
      • Zwolle, Overijssel, Netherlands, 8025 AB
        • Withdrawn
        • Local Institution - 0195
    • South Holland
      • Leiden, South Holland, Netherlands, 2333 ZA
        • Recruiting
        • Leids Universitair Medisch Centrum
        • Contact:
          • Egbert Smit, Site 0036
          • Phone Number: 31715262950
      • The Hague, South Holland, Netherlands, 2512 VA
        • Withdrawn
        • Local Institution - 0315
  • New Zealand
      • Auckland, New Zealand, 1023
        • Recruiting
        • Auckland City Hospital
        • Contact:
          • Aileen Ludlow, Site 0405
          • Phone Number: 6493074949(Ext24512)
      • Dunedin, New Zealand, 9016
        • Not yet recruiting
        • Local Institution - 0425
        • Contact:
          • Site 0425
      • Wellington, New Zealand, 6021
        • Not yet recruiting
        • Local Institution - 0406
        • Contact:
          • Site 0406
    • Bay of Plenty
      • Tauranga, Bay of Plenty, New Zealand, 3112
        • Recruiting
        • Tauranga Hospital
        • Contact:
          • Richard North, Site 0447
          • Phone Number: 6475798153
      • Tauranga, Bay of Plenty, New Zealand, 3112
        • Not yet recruiting
        • Local Institution - 0407
        • Contact:
          • Site 0407
  • Poland
      • Prabuty, Poland, 82-550
        • Recruiting
        • Szpital Specjalistyczny w Prabutach Spolka z o.o.
        • Contact:
          • Anna Lowczak, Site 0258
          • Phone Number: +48503022396
    • Greater Poland Voivodeship
      • Konin, Greater Poland Voivodeship, Poland, 62-500
        • Not yet recruiting
        • Local Institution - 0255
        • Contact:
          • Site 0255
      • Poznan, Greater Poland Voivodeship, Poland, 60-693
        • Recruiting
        • Med-Polonia Sp. z o.o.
        • Contact:
          • Rodryg Ramlau, Site 0261
          • Phone Number: 48618549040
      • Poznan, Greater Poland Voivodeship, Poland, 60-192
        • Recruiting
        • Centrum Medyczne Pratia Poznan
        • Contact:
          • Marek Kotlarski, Site 0256
          • Phone Number: 512491461
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-796
        • Recruiting
        • Centrum Onkologii im. Prof. Franciszka Lukaszczyka
        • Contact:
          • Bogdan Zurawski, Site 0260
          • Phone Number: 48501446778
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 04-125
        • Withdrawn
        • Local Institution - 0259
    • West Pomeranian Voivodeship
      • Koszalin, West Pomeranian Voivodeship, Poland, 75-581
        • Not yet recruiting
        • Local Institution - 0257
        • Contact:
          • Site 0257
    • Łódź Voivodeship
      • Lodz, Łódź Voivodeship, Poland, 93-338
        • Recruiting
        • Instytut Centrum Zdrowia Matki Polki
        • Contact:
          • Ewa Kalinka, Site 0254
          • Phone Number: +48530770073
  • Portugal
      • Coimbra, Portugal, 3040
        • Not yet recruiting
        • Local Institution - 0404
        • Contact:
          • Site 0404
      • Porto, Portugal, 4200-072
        • Recruiting
        • Instituto Português de Oncologia do Porto Francisco Gentil, EPE
        • Contact:
          • Maria Cassiano Neves, Site 0403
          • Phone Number: 961760869
      • Porto, Portugal, 4200-319
        • Not yet recruiting
        • Local Institution - 0401
        • Contact:
          • Site 0401
    • Lisbon District
      • Lisbon, Lisbon District, Portugal, 1099-023
        • Recruiting
        • Instituto Português de Oncologia de Lisboa Francisco Gentil
        • Contact:
          • Telma Sequeira, Site 0402
          • Phone Number: 914000669
  • Romania
      • Cluj-Napoca, Romania, 400015
        • Recruiting
        • Institutul Oncologic Cluj
        • Contact:
          • Tudor Ciuleanu, Site 0301
          • Phone Number: 40745646368
      • Iași, Romania, 700483
        • Recruiting
        • Institutul Regional de Oncologie
        • Contact:
          • Dana Clement, Site 0300
          • Phone Number: 40744692062
      • Ploieşti, Romania, 100337
        • Recruiting
        • Spitalul Municipal Schuller Ploiești
        • Contact:
          • Nita Amedeia, Site 0297
          • Phone Number: +40728121201
    • Bucharest
      • Bucharest, Bucharest, Romania, 013812
        • Recruiting
        • SC Memorial Healthcare International SRL
        • Contact:
          • Ingrid Iordan, Site 0296
          • Phone Number: 40721298677
      • Bucharest, Bucharest, Romania, 022338
        • Recruiting
        • Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
        • Contact:
          • Aurelia Alexandru, Site 0298
          • Phone Number: 40723289606
    • Cluj
      • Florești, Cluj, Romania, 407280
        • Recruiting
        • SC Radiotherapy Center Cluj SRL
        • Contact:
          • Andrei Ungureanu, Site 0299
          • Phone Number: 40742206212
    • Dolj
      • Craiova, Dolj, Romania, 200542
        • Recruiting
        • Centrul de Oncologie "Sfântul Nectarie"
        • Contact:
          • Michael Schenker, Site 0295
          • Phone Number: 40727774974
  • Saudi Arabia
    • Eastern Province
      • Dammam, Eastern Province, Saudi Arabia, 31444
        • Not yet recruiting
        • Local Institution - 0440
        • Contact:
          • Site 0440
    • Makkah Al Mukarramah
      • Jeddah, Makkah Al Mukarramah, Saudi Arabia, 23433
        • Not yet recruiting
        • Local Institution - 0409
        • Contact:
          • Site 0409
    • Riyadh Region
      • Riyadh, Riyadh Region, Saudi Arabia, 11426
        • Not yet recruiting
        • Local Institution - 0408
        • Contact:
          • Site 0408
  • South Africa
    • GP
      • Johannesburg, GP, South Africa, 2193
        • Not yet recruiting
        • Local Institution - 0429
        • Contact:
          • Site 0429
      • Pretoria, GP, South Africa, 0181
        • Recruiting
        • Life Groenkloof
        • Contact:
          • Graham Cohen, Site 0432
          • Phone Number: 012 346 6701
      • Sandton, GP, South Africa, 2196
        • Recruiting
        • Sandton Oncology Medical Group (Pty) Ltd
        • Contact:
          • Sze Chan, Site 0427
          • Phone Number: 27118830900
    • Gauteng
      • Soweto, Gauteng, South Africa, 2013
        • Not yet recruiting
        • Local Institution - 0431
        • Contact:
          • Site 0431
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7570
        • Recruiting
        • Cape Town Oncology Trials
        • Contact:
          • Corlia Coetzee, Site 0428
          • Phone Number: 27219443832
  • South Korea
      • Yangsan, South Korea, 50612
        • Not yet recruiting
        • Local Institution - 0491
        • Contact:
          • Site 0491
    • Chungcheongbuk-do [Chungbuk]
      • Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea, 28644
        • Recruiting
        • Chungbuk National University Hospital
        • Contact:
          • Ki Hyeong Lee, Site 0220
          • Phone Number: 82432696015
    • Incheon-gwangyeoksi [Incheon]
      • Namdong-gu, Incheon-gwangyeoksi [Incheon], South Korea, 21565
        • Recruiting
        • Gachon University Gil Medical Center
        • Contact:
          • Eun Kyung Cho, Site 0234
          • Phone Number: 82324603383
    • Jeonranamdo
      • Hwasun, Jeonranamdo, South Korea, 58128
        • Recruiting
        • Chonnam National University Hwasun Hospital
        • Contact:
          • Young-Chul Kim, Site 0458
          • Phone Number: 821036352876
    • Kyǒnggi-do
      • Goyang-si, Kyǒnggi-do, South Korea, 10408
        • Recruiting
        • National Cancer Center
        • Contact:
          • Ji-Youn Han, Site 0201
          • Phone Number: +82319201154
      • Seongnam-si, Kyǒnggi-do, South Korea, 13496
        • Recruiting
        • CHA Bundang Medical Center, CHA University
        • Contact:
          • Joo-Hang Kim, Site 0450
          • Phone Number: 82-2-2228-8131
    • Pusan-Kwangyǒkshi
      • Busan, Pusan-Kwangyǒkshi, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital
        • Contact:
          • Jung Seop Eom, Site 0454
          • Phone Number: +82512407889
    • Sejong-si
      • Seoul, Sejong-si, South Korea, 8308
        • Not yet recruiting
        • Local Institution - 0488
        • Contact:
          • Site 0488
    • Seoul-teukbyeolsi [Seoul]
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 06351
        • Recruiting
        • Samsung Medical Center
        • Contact:
          • Jin Seok Ahn, Site 0176
          • Phone Number: 821099333453
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Contact:
          • Hye Ryun Kim, Site 0175
          • Phone Number: 82222284190
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 05505
        • Recruiting
        • Asan Medical Center
        • Contact:
          • Dae Ho Lee, Site 0233
          • Phone Number: 82230103214
    • Taegu-Kwangyǒkshi
      • Daegu, Taegu-Kwangyǒkshi, South Korea, 42601
        • Not yet recruiting
        • Local Institution - 0490
        • Contact:
          • Site 0490
      • Deagu, Taegu-Kwangyǒkshi, South Korea, 41404
        • Not yet recruiting
        • Local Institution - 0489
        • Contact:
          • Site 0489
  • Spain
      • Málaga, Spain, 29011
        • Recruiting
        • H.R.U Málaga - Hospital General
        • Contact:
          • Manuel Cobo-Dols, Site 0266
          • Phone Number: 00349422033350000
      • Seville, Spain, 41013
        • Recruiting
        • Hospital Universitario Virgen del Rocio
        • Contact:
          • Miriam Alonso Garcia, Site 0268
          • Phone Number: 34955013068
      • Valencia, Spain, 46026
        • Not yet recruiting
        • Local Institution - 0269
        • Contact:
          • Site 0269
    • A Coruña [La Coruña]
      • A Coruña, A Coruña [La Coruña], Spain, 15006
        • Recruiting
        • CHUAC-Hospital Teresa Herrera
        • Contact:
          • Maria Garcia Campelo, Site 0270
          • Phone Number: 34981178353
    • Barcelona [Barcelona]
      • Barcelona, Barcelona [Barcelona], Spain, 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebron
        • Contact:
          • Ilaria Priano, Site 0264
          • Phone Number: 34932746085
    • Catalunya [Cataluña]
      • Barcelona, Catalunya [Cataluña], Spain, 08041
        • Recruiting
        • Hospital de la Santa Creu i Sant Pau
        • Contact:
          • Margarita Majem Tarruella, Site 0434
          • Phone Number: 34935565651
      • L'Hospitalet de Llobregat, Catalunya [Cataluña], Spain, 08908
        • Recruiting
        • Institut Català d'Oncologia - L'Hospitalet
        • Contact:
          • NOELIA Vilarino Quintela, Site 0267
          • Phone Number: 34932275402
    • Illes Balears [Islas Baleares]
      • Palma, Illes Balears [Islas Baleares], Spain, 07198
        • Recruiting
        • Hospital Son Llatzer
        • Contact:
          • Juan Coves Sarto, Site 0414
          • Phone Number: 348712020001629
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, Spain, 28034
        • Recruiting
        • Hospital Universitario Ramón y Cajal
        • Contact:
          • Pilar Garrido Lopez, Site 0413
          • Phone Number: (+34)913368263
      • Madrid, Madrid, Comunidad de, Spain, 28041
        • Recruiting
        • Hospital Universitario 12 de Octubre
        • Contact:
          • Luis Paz-Ares Rodriguez, Site 0265
          • Phone Number: 0034913908922
      • Majadahonda, Madrid, Comunidad de, Spain, 28222
        • Recruiting
        • Hospital Universitario Puerta de Hierro Majadahonda
        • Contact:
          • Mariano Provencio Pulla, Site 0426
          • Phone Number: 34911917759
    • València
      • Valencia, València, Spain, 46015
        • Not yet recruiting
        • Local Institution - 0411
        • Contact:
          • Site 0411
  • Switzerland
      • Basel, Switzerland, 4031
        • Withdrawn
        • Local Institution - 0290
      • Münsterlingen, Switzerland, 8596
        • Withdrawn
        • Local Institution - 0398
    • Canton Ticino
      • Bellinzona, Canton Ticino, Switzerland, 6500
        • Withdrawn
        • Local Institution - 0341
    • Canton of Vaud
      • Lausanne, Canton of Vaud, Switzerland, 1011
        • Not yet recruiting
        • Local Institution - 0291
        • Contact:
          • Site 0291
  • Taiwan
      • New Taipei City, Taiwan, 235
        • Recruiting
        • Taipei Medical University Shuang Ho Hospital
        • Contact:
          • Kang-Yun Lee, Site 0118
          • Phone Number: 8862224900882714
      • Taichung, Taiwan, 407
        • Recruiting
        • Taichung Veterans General Hospital
        • Contact:
          • Tsung-Ying Yang, Site 0117
          • Phone Number: 8864235925253218
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
        • Contact:
          • Jin-Yuan Shih, Site 0116
          • Phone Number: 88622312345662905
      • Taipei, Taiwan, 11217
        • Recruiting
        • Taipei Veterans General Hospital
        • Contact:
          • Yung-Hung Luo, Site 0119
          • Phone Number: 886921770588
    • Kaohsiung
      • Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan, 83301
        • Recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Contact:
          • Chin-Chou Wang, Site 0445
          • Phone Number: 88677317123
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01140
        • Recruiting
        • Adana Medical Park Seyhan Hastanesi
        • Contact:
          • Ahmet Taner Sumbul, Site 0361
          • Phone Number: 905056166338
      • Adana, Turkey (Türkiye), 01370
        • Not yet recruiting
        • Local Institution - 0365
        • Contact:
          • Site 0365
      • Ankara, Turkey (Türkiye), 06230
        • Recruiting
        • Hacettepe Universite Hastaneleri
        • Contact:
          • Mustafa Erman, Site 0383
          • Phone Number: +905334318506
      • Ankara, Turkey (Türkiye), 06800
        • Not yet recruiting
        • Local Institution - 0362
        • Contact:
          • Site 0362
      • Istanbul, Turkey (Türkiye), 34214
        • Recruiting
        • Medipol Mega Universite Hastanesi
        • Contact:
          • Ahmet Bilici, Site 0410
          • Phone Number: +905325280486
      • Istanbul, Turkey (Türkiye), 34722
        • Not yet recruiting
        • Local Institution - 0364
        • Contact:
          • Site 0364
  • United Kingdom
      • London, United Kingdom, W1G 6AD
        • Recruiting
        • Sarah Cannon Research Institute UK
        • Contact:
          • Anja Williams, Site 0464
          • Phone Number: 02032195200
      • Manchester, United Kingdom, M20 4BX
        • Withdrawn
        • Local Institution - 0020
      • Metropolitan Borough of Wirral, United Kingdom, CH63 4JY
        • Withdrawn
        • Local Institution - 0024
      • Reading, United Kingdom, RG1 5AN
        • Recruiting
        • Royal Berkshire Hospital
        • Contact:
          • Shawn Ellis, Site 0463
          • Phone Number: 01183225111
    • Devon
      • Exeter, Devon, United Kingdom, EX2 5DW
        • Withdrawn
        • Local Institution - 0441
    • Dundee City
      • Dundee, Dundee City, United Kingdom, DD1 9SY
        • Completed
        • Local Institution - 0349
    • Falkirk
      • Larbert, Falkirk, United Kingdom, FK5 4WR
        • Recruiting
        • Forth Valley Royal Hospital
        • Contact:
          • Nicola Steele, Site 0271
          • Phone Number: 01413017118
    • Glasgow City
      • Glasgow, Glasgow City, United Kingdom, g12OYN
        • Not yet recruiting
        • Local Institution - 0189
        • Contact:
          • Site 0189
    • Kensington and Chelsea
      • London, Kensington and Chelsea, United Kingdom, SW3 6JJ
        • Withdrawn
        • Local Institution - 0021
    • Leicestershire
      • Leicester, Leicestershire, United Kingdom, LE1 5WW
        • Recruiting
        • Leicester Royal Infirmary
        • Contact:
          • Samreen Ahmed, Site 0026
          • Phone Number: 441162586318
    • London, City of
      • London, London, City of, United Kingdom, EC1A 7BE
        • Recruiting
        • St Bartholomew's Hospital
        • Contact:
          • Adam Januszewski, Site 0348
          • Phone Number: 447854094052
      • London, London, City of, United Kingdom, SE1 9RT
        • Not yet recruiting
        • Local Institution - 0001
        • Contact:
          • Site 0001
  • United States
    • Alabama
      • Mobile, Alabama, United States, 36604
        • Not yet recruiting
        • Local Institution - 0487
        • Contact:
          • Site 0487
    • Arizona
      • Tucson, Arizona, United States, 85723
        • Recruiting
        • Southern Arizona VA Health Care System
        • Contact:
          • Thomas Hanzlik, Site 0368
          • Phone Number: 580-792-1450
    • California
      • Los Angeles, California, United States, 90404
        • Withdrawn
        • Local Institution - 0112
      • Sacramento, California, United States, 95817
        • Recruiting
        • University of California Davis (UC Davis) Comprehensive Cancer Center
        • Contact:
          • Tianhong Li, Site 0304
          • Phone Number: 718-555-1212
      • San Francisco, California, United States, 94115
        • Recruiting
        • San Francisco Oncology Associates
        • Contact:
          • Kevin Kim, Site 0159
          • Phone Number: 415-885-8600
      • Santa Monica, California, United States, 90404
        • Recruiting
        • UCLA Hematology/Oncology - Santa Monica
        • Contact:
          • Edward Garon, Site 0111
          • Phone Number: 310-926-5333
    • Colorado
      • Grand Junction, Colorado, United States, 81501
        • Not yet recruiting
        • Local Institution - 0500
        • Contact:
          • Site 0500
      • Westminster, Colorado, United States, 80023
        • Not yet recruiting
        • Local Institution - 0472
        • Contact:
          • Site 0472
    • Florida
      • Miami, Florida, United States, 33136
        • Recruiting
        • University of Miami Hospital and Clinics, Sylvester Cancer Center
        • Contact:
          • Estelamari Rodriguez, Site 0206
          • Phone Number: 305-689-4059
      • Pembroke Pines, Florida, United States, 33028
        • Recruiting
        • Memorial Hospital West
        • Contact:
          • Gelenis Domingo, Site 0162
          • Phone Number: 000-000-0000
      • St. Petersburg, Florida, United States, 33705
        • Recruiting
        • Florida Cancer Specialists - North
        • Contact:
          • Mamta Choksi, Site 0358
          • Phone Number: 727-842-8411
      • Tamarac, Florida, United States, 33321
        • Not yet recruiting
        • Local Institution - 0477
        • Contact:
          • Site 0477
      • West Palm Beach, Florida, United States, 33401
        • Recruiting
        • Florida Cancer Specialists - East
        • Contact:
          • Todd Gersten, Site 0360
          • Phone Number: 561-366-4100
    • Illinois
      • Chicago Ridge, Illinois, United States, 60415
        • Recruiting
        • Affiliated Oncologists, LLC
        • Contact:
          • Rami Haddad, Site 0376
          • Phone Number: 111111
    • Kansas
      • Wichita, Kansas, United States, 67214
        • Recruiting
        • Cancer Center of Kansas
        • Contact:
          • Shaker Dakhil, Site 0251
          • Phone Number: 316-262-4467
    • Kentucky
      • Edgewood, Kentucky, United States, 41017
        • Recruiting
        • Saint Elizabeth Medical Center Edgewood
        • Contact:
          • Colleen Darnell, Site 0128
          • Phone Number: 859-301-4000
      • Lexington, Kentucky, United States, 40503
        • Recruiting
        • Baptist Health Lexington
        • Contact:
          • Firas Badin, Site 0130
          • Phone Number: 859-260-6100
      • Paducah, Kentucky, United States, 42003
        • Not yet recruiting
        • Local Institution - 0502
        • Contact:
          • Site 0502
    • Michigan
      • Royal Oak, Michigan, United States, 48073
        • Not yet recruiting
        • Local Institution - 0473
        • Contact:
          • Site 0473
    • Mississippi
      • Hattiesburg, Mississippi, United States, 39401-7233
        • Recruiting
        • Hattiesburg Clinic Hematology/Oncology
        • Contact:
          • John Hrom, Site 0226
          • Phone Number: 601-261-1700
    • Missouri
      • Kansas City, Missouri, United States, 64132
        • Not yet recruiting
        • Local Institution - 0498
        • Contact:
          • Site 0498
    • Montana
      • Bozeman, Montana, United States, 59715
        • Completed
        • Local Institution - 0308
    • Nevada
      • Reno, Nevada, United States, 89502
        • Recruiting
        • Renown Regional Medical Center
        • Contact:
          • Katharine Thomas, Site 0207
          • Phone Number: 775-985-4000
    • New Jersey
      • Paterson, New Jersey, United States, 07503
        • Completed
        • Local Institution - 0346
    • New Mexico
      • Albuquerque, New Mexico, United States, 87108
        • Completed
        • Local Institution - 0381
    • New York
      • Hawthorne, New York, United States, 10532
        • Active, not recruiting
        • Local Institution - 0356
      • New York, New York, United States, 10016
        • Recruiting
        • Veterans Affairs New York Harbor Healthcare System
        • Contact:
          • Daniel Becker, Site 0392
          • Phone Number: 212-523-4000
      • Northport, New York, United States, 11768
        • Withdrawn
        • Local Institution - 0380
      • Rochester, New York, United States, 14642
        • Recruiting
        • University of Rochester Medical Center
        • Contact:
          • Arpan Patel, Site 0325
          • Phone Number: 315-525-2102
      • Syracuse, New York, United States, 13210
        • Recruiting
        • Suny Upstate Medical University
        • Contact:
          • Bhaskara Reddy Madhira, Site 0324
          • Phone Number: 314-691-8862
      • The Bronx, New York, United States, 10468
        • Withdrawn
        • Local Institution - 0357
    • North Carolina
      • Asheville, North Carolina, United States, 28806
        • Completed
        • Local Institution - 0352
      • Greenville, North Carolina, United States, 27858
        • Recruiting
        • East Carolina University
        • Contact:
          • Sameer Batoo, Site 0351
          • Phone Number: 252-744-4929
    • Ohio
      • Canton, Ohio, United States, 44708
        • Withdrawn
        • Local Institution - 0369
      • Centerville, Ohio, United States, 45459
        • Not yet recruiting
        • Local Institution - 0486
        • Contact:
          • Site 0486
      • Cincinnati, Ohio, United States, 45219
        • Recruiting
        • University of Cincinnati Medical Center
        • Contact:
          • Jennifer Leddon, Site 0141
      • Cleveland, Ohio, United States, 44106
        • Completed
        • Local Institution - 0199
      • Massillon, Ohio, United States, 44646
        • Withdrawn
        • Local Institution - 0366
    • Pennsylvania
      • Lancaster, Pennsylvania, United States, 17601
        • Recruiting
        • Lancaster General Hospital - Ann B Barshinger Cancer Institute
        • Contact:
          • Samuel Kerr, Site 0272
          • Phone Number: 717-215-9561
    • Texas
      • Abilene, Texas, United States, 79606
        • Recruiting
        • Texas Oncology - West Texas
        • Contact:
          • Pankaj Khandelwal, Site 0359
          • Phone Number: 000-000-0000
      • Harlingen, Texas, United States, 78550
        • Withdrawn
        • Local Institution - 0305
      • Houston, Texas, United States, 77030
        • Recruiting
        • University of Texas MD Anderson Cancer Center
        • Contact:
          • Mehmet Altan, Site 0378
          • Phone Number: 203-809-3721
      • Tyler, Texas, United States, 75701
        • Recruiting
        • The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center
        • Contact:
          • Robert Droder, Site 0303
          • Phone Number: 903-595-7093
    • Utah
      • Salt Lake City, Utah, United States, 84112
        • Not yet recruiting
        • Local Institution - 0302
        • Contact:
          • Site 0302
    • Washington
      • Lacey, Washington, United States, 98503
        • Not yet recruiting
        • Local Institution - 0499
        • Contact:
          • Site 0499

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria

  • Participants must have histologically confirmed Stage IV or recurrent Non-small Cell Lung Cancer (NSCLC) of non-squamous (NSQ) histology with no prior systemic anti-cancer therapy given as primary therapy for advanced or metastatic disease.
  • Participants must have measurable PD-L1 ≥ 1% Tumor Cell (TC) score by the investigational PD-L1 immunohistochemistry (IHC) assay VENTANA PD-L1 (SP263) CDx Assay conducted by central laboratory during the screening period prior to randomization.
  • Participants must have measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria.
  • Participants must have an Easter Cooperative Oncology Group (ECOG) performance status of ≤ 1 at screening.
  • Participants must have a life expectancy of at least 3 months at the time of randomization.

Exclusion Criteria

  • Participants must not be pregnant and/or breastfeeding.
  • Participants with epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or ROS-1 mutations that are sensitive to available targeted inhibitor therapy. Participants with unknown EGFR, ALK, or ROS-1 status are excluded.
  • Participants with known BRAFV600E mutations, that are sensitive to available targeted inhibitor therapy; participants with known activating rearranged during transfection (RET) mutations or neurotrophic tyrosine receptor kinase (NTRK) fusion gene alterations are excluded. Participants with unknown or indeterminate BRAF mutation, activating RET mutations or NTRK fusion gene alterations are eligible.
  • Participants must not have untreated central nervous system (CNS) metastases.
  • Participants must not have leptomeningeal metastases (carcinomatous meningitis).
  • Participants must not have concurrent malignancy requiring treatment.
  • Participants must not have an active autoimmune disease.
  • Participants must not have history of interstitial lung disease or pneumonitis that required oral or intravenous (IV) glucocorticoids to assist with management.
  • Participants must not have a history of myocarditis.
  • Participants must not have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or other antibody or drug targeting T-cell co-stimulation or checkpoint pathways.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Arm A
Drug: Carboplatin
Specified dose on specified days
Drug: Cisplatin
Specified dose on specified days
Drug: Pemetrexed
Specified dose on specified days
Drug: Nivolumab
Specified dose on specified days
Drug: Relatlimab
Specified dose on specified days
Active Comparator: Arm B
Drug: Carboplatin
Specified dose on specified days
Drug: Cisplatin
Specified dose on specified days
Drug: Pemetrexed
Specified dose on specified days
Drug: Pembrolizumab
Specified dose on specified days

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Overall survival (OS) in randomized participants with PD-L1 1% to 49%
Time Frame: Up to 5 years
Up to 5 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Overall response rate (ORR)
Time Frame: Up to 5 years
Up to 5 years
Duration of response (DoR)
Time Frame: Up to 5 years
Up to 5 years
Number of participants with adverse events (AEs)
Time Frame: Up to 2.5 years
Up to 2.5 years
Number of participants with serious adverse events (SAEs)
Time Frame: Up to 2.5 years
Up to 2.5 years
Number of participants with immune-mediated adverse events (IMAEs)
Time Frame: Up to 2.5 years
Up to 2.5 years
The time until definitive deterioration based on non-small cell lung cancer - symptom assessment questionnaire (NSCLC-SAQ) total score
Time Frame: Up to 2 years
Up to 2 years
OS in randomized participants with PD-L1 ≥ 1%
Time Frame: Up to 5 years
Up to 5 years
Progression-free survival (PFS) as assessed by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) per blinded independent central review (BICR)
Time Frame: Up to 5 years
Up to 5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bristol-Myers Squibb

Investigators

  • Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 7, 2024

Primary Completion (Estimated)

July 30, 2030

Study Completion (Estimated)

August 4, 2032

Study Registration Dates

First Submitted

August 16, 2024

First Submitted That Met QC Criteria

August 16, 2024

First Posted (Actual)

August 20, 2024

Study Record Updates

Last Update Posted (Actual)

May 20, 2026

Last Update Submitted That Met QC Criteria

May 19, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CA224-1093
  • 2024-513682-40 (Other Identifier: EU CTR)
  • U1111-1306-8896 (Other Identifier: WHO)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

IPD Sharing Time Frame

See Plan Description

IPD Sharing Access Criteria

See Plan Description

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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