A Retrospective Cohort Study on Predicting Delayed Graft Function in Liver Transplant Patients with Hepatocellular Carcinoma: a Nomogram and Machine Learning Approaches.

October 3, 2024 updated by: Jian You

Background: This study aimed to develop a predictive model for delayed graft function (DGF) in liver transplant patients with hepatocellular carcinoma (HCC) based on preoperative biochemical indicators, using both logistic regression and XGBoost machine learning algorithms.

Methods: A retrospective cohort study was conducted, including 131 liver transplant patients from January 2020 to April 2022. Preoperative biochemical markers and hematological parameters were analyzed. Logistic regression and XGBoost models were constructed to predict DGF, and their performance was evaluated using the area under the ROC curve (AUC). Shapley Additive Explanations (SHAP) analysis was employed to interpret the feature contributions.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Procedure: Liver transplantation

Study Type

Observational

Enrollment (Actual)

131

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

China
- Hubei
  - Wuhan, Hubei, China, 430071
    - Zhongnan Hospital of Wuhan University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Child

Accepts Healthy Volunteers

Sampling Method

Probability Sample

Study Population

Patients receiving a liver transplant between January 2020 and April 2024.

Description

Inclusion Criteria:

Patients with liver cancer aged between 18 and 75 years.
Patients who have received liver transplantation.
Complete preoperative and postoperative medical imaging data, clinical records and pathological test reports are available.

Exclusion Criteria:

Primary non-hepatocellular carcinoma
Recipients were younger than 18 years and older than 75 years
Due to incomplete or missing clinical data, this dataset did not meet the criteria for inclusion in the statistical analysis.
Serious complications associated with liver transplantation, such as acute transplant rejection or transplant liver failure, occur within 7 days after surgery.
Re-surgery within 7 days after surgery due to liver transplant-related complications or other surgical procedures, such as transplant site infection or other major surgery.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
TBIL/AST/ALT/INR Time Frame: Results of biochemical examination on the 7th day after liver transplantation in patients with hepatocellular carcinoma.	Results of biochemical examination on the 7th day after liver transplantation in patients with hepatocellular carcinoma.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jian You

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2020

Primary Completion (Actual)

April 30, 2024

Study Completion (Actual)

April 30, 2024

Study Registration Dates

First Submitted

October 1, 2024

First Submitted That Met QC Criteria

October 3, 2024

First Posted (Actual)

October 4, 2024

Study Record Updates

Last Update Posted (Actual)