A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) (MOVe-NOW)

September 11, 2026 updated by: Merck Sharp & Dohme LLC

A Phase 3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adults With COVID-19 at High Risk for Disease Progression

Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, or they take other medicines that may react with a treatment and cause an unwanted effect.

Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

3082

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Argentina
    • Buenos Aires
      • Buenos Aires., Buenos Aires, Argentina, C1431FWO
        • Recruiting
        • CEMIC ( Site 0101)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-911-36115955
      • Ciudad Autonoma de Buenos Aires., Buenos Aires, Argentina, C1199ABB
        • Recruiting
        • Hospital Italiano de Buenos Aires ( Site 0107)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-911-36115955
      • Mar del Plata, Buenos Aires, Argentina, B7600FZO
        • Recruiting
        • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0111)
        • Contact:
          • Study Coordinator
          • Phone Number: +542234963224
      • Morón, Buenos Aires, Argentina, 1708
        • Recruiting
        • Nefra Medical Care - Moron ( Site 0109)
        • Contact:
          • Study Coordinator
          • Phone Number: +541146291083
  • Brazil
      • São Paulo, Brazil, 05403-010
        • Recruiting
        • Centro de Pesquisa Clinica Institucional do HCFMUSP - CPCi ( Site 0403)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 11 2661-7214
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30180-080
        • Completed
        • Hospital Felicio Rocho (HFR) - Nucleo de Ciencias da Saude ( Site 0402)
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, Brazil, 59020-500
        • Recruiting
        • Instituto Atena de Pesquisa Clinica ( Site 0406)
        • Contact:
          • Study Coordinator
          • Phone Number: +558420203430
    • Rondônia
      • Porto Velho, Rondônia, Brazil, 76812329
        • Recruiting
        • Centro de Pesquisa em Medicina Tropical - CEPEM - Rondonia ( Site 0405)
        • Contact:
          • Study Coordinator
          • Phone Number: +556932196012
    • São Paulo
      • Campinas, São Paulo, Brazil, 13060-803
        • Recruiting
        • Centro de Pesquisa Sao Lucas ( Site 0401)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 019997718356
  • Bulgaria
      • Burgas, Bulgaria, 8000
        • Recruiting
        • Medical Center 'Medconsult' Burgas EOOD ( Site 0510)
        • Contact:
          • Study Coordinator
          • Phone Number: +359879886842
      • Lovech, Bulgaria, 5500
        • Recruiting
        • Medconsult Pleven - Lovech ( Site 0501)
        • Contact:
          • Study Coordinator
          • Phone Number: +35968629195
      • Montana, Bulgaria, 3400
        • Recruiting
        • Medical Center Hera ( Site 0507)
        • Contact:
          • Study Coordinator
          • Phone Number: +35032261110
      • Montana, Bulgaria, 3403
        • Recruiting
        • MHAT "Dr. Stamen Iliev" Montana-Department of Pulmonology ( Site 0504)
        • Contact:
          • Study Coordinator
          • Phone Number: +35996306881
      • Pleven, Bulgaria, 5800
        • Recruiting
        • Medconsult Pleven ( Site 0503)
        • Contact:
          • Study Coordinator
          • Phone Number: +35964910999
      • Plovdiv, Bulgaria, 4023
        • Recruiting
        • DKC V - Plovdiv ( Site 0508)
        • Contact:
          • Study Coordinator
          • Phone Number: 032261110
      • Rousse, Bulgaria, 7002
        • Recruiting
        • SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD ( Site 0502)
        • Contact:
          • Study Coordinator
          • Phone Number: +35982813961
      • Sofia, Bulgaria, 1510
        • Recruiting
        • Medical Center Hera EOOD ( Site 0505)
        • Contact:
          • Study Coordinator
          • Phone Number: 359882441433
      • Sofia, Bulgaria, 1113
        • Recruiting
        • Diagnostic Consultative Center 22 - Sofia ( Site 0500)
        • Contact:
          • Study Coordinator
          • Phone Number: +3528929840
      • Varna, Bulgaria, 9020
        • Recruiting
        • Medical Centre Pratia Clinic EOOD ( Site 0511)
        • Contact:
          • Study Coordinator
          • Phone Number: +359882655182
    • Pazardzhik
      • Velingrad, Pazardzhik, Bulgaria, 4600
        • Recruiting
        • Medical Center Asclepius ( Site 0506)
        • Contact:
          • Study Coordinator
          • Phone Number: +35935952561
    • Vratsa
      • Kozloduy, Vratsa, Bulgaria, 3320
        • Recruiting
        • Medical Center Zdrave 1 ( Site 0509)
        • Contact:
          • Study Coordinator
          • Phone Number: +359878619077
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia, 50016
        • Recruiting
        • IPS SURA San Diego ( Site 0806)
        • Contact:
          • Study Coordinator
          • Phone Number: +573183399032
    • Atlántico
      • Barranquilla, Atlántico, Colombia, 080020
        • Recruiting
        • IPS Centro Científico Asistencial S.A.S ( Site 0800)
        • Contact:
          • Study Coordinator
          • Phone Number: +576053485939
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 111321
        • Recruiting
        • Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0804)
        • Contact:
          • Study Coordinator
          • Phone Number: +576015948650
      • Bogotá, Bogota D.C., Colombia, 110111
        • Active, not recruiting
        • Clinica Colsanitas - Sede Reina Sofia ( Site 0807)
    • Cesar Department
      • Valledupar, Cesar Department, Colombia, 200001
        • Recruiting
        • Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0801)
        • Contact:
          • Study Coordinator
          • Phone Number: 573015371818
    • Departamento de Córdoba
      • Montería, Departamento de Córdoba, Colombia, 230002
        • Recruiting
        • IMAT S.A.S ( Site 0805)
        • Contact:
          • Study Coordinator
          • Phone Number: 3135342052
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Recruiting
        • Fundación Valle del Lili ( Site 0803)
        • Contact:
          • Study Coordinator
          • Phone Number: 57 602 3319090x4022
  • Finland
    • Uusimaa
      • Helsinki, Uusimaa, Finland, 00290
        • Recruiting
        • MeVac - Meilahti Vaccine Research Center ( Site 1200)
        • Contact:
          • Study Coordinator
          • Phone Number: +358504270446
  • France
    • Bourgogne-Franche-Comté
      • Dijon, Bourgogne-Franche-Comté, France, 21000
        • Recruiting
        • Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital F-Centre d'Investigation Clinique - Plur ( Site 1301)
        • Contact:
          • Study Coordinator
          • Phone Number: 3380295920
    • Pays de la Loire Region
      • Saint Priest En Jarez, Pays de la Loire Region, France, 42270
        • Recruiting
        • CHU de Saint-Etienne ( Site 1302)
        • Contact:
          • Study Coordinator
          • Phone Number: +33477120587
    • Rhone
      • Pierre-Bénite, Rhone, France, 69310
        • Recruiting
        • centre hospitalier lyon sud ( Site 1303)
        • Contact:
          • Study Coordinator
          • Phone Number: +33771581547
    • Île-de-France Region
      • Paris, Île-de-France Region, France, 75013
        • Recruiting
        • Pitie Salpetriere University Hospital-Infectious Disease - Tropical Diseases ( Site 1300)
        • Contact:
          • Study Coordinator
          • Phone Number: +33142160101
  • Georgia
      • Tbilisi, Georgia, 0186
        • Recruiting
        • Curatio Clinic - Main Location ( Site 1401)
        • Contact:
          • Study Coordinator
          • Phone Number: +995 32 243 01 01
      • Tbilisi, Georgia, 0114
        • Recruiting
        • New Hospitals ( Site 1409)
        • Contact:
          • Study Coordinator
          • Phone Number: +995 322 190 190
    • Adjara
      • Batumi, Adjara, Georgia, 6000
        • Recruiting
        • Clinic Health - Batumi ( Site 1405)
        • Contact:
          • Study Coordinator
          • Phone Number: +995591409090
      • Batumi, Adjara, Georgia, 6010
        • Recruiting
        • LTD High Technology Hospital Medcenter ( Site 1408)
        • Contact:
          • Study Coordinator
          • Phone Number: +995596226060
      • Batumi, Adjara, Georgia, 6010
        • Recruiting
        • University Clinic of Innovative Medicine ( Site 1400)
        • Contact:
          • Study Coordinator
          • Phone Number: +995 422 25 20 08
      • Batumi, Adjara, Georgia, 6000
        • Suspended
        • Family Medical Regional Center ( Site 1404)
      • Tbilisi, Adjara, Georgia, 0186
        • Recruiting
        • Caucasus Medical Centre ( Site 1406)
        • Contact:
          • Study Coordinator
          • Phone Number: +995322600600
    • Samegrelo and Zemo Svaneti
      • Zugdidi, Samegrelo and Zemo Svaneti, Georgia, 2100
        • Recruiting
        • "Georgian Clinics" JSC ( Site 1410)
        • Contact:
          • Study Coordinator
          • Phone Number: +995577733383
  • Germany
    • Bavaria
      • Munich, Bavaria, Germany, 81675
        • Recruiting
        • TUM Klinikum ( Site 1502)
        • Contact:
          • Study Coordinator
          • Phone Number: 00498941406323
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60590
        • Completed
        • Universitätsklinikum Frankfurt Goethe-Universität ( Site 1503)
    • North Rhine-Westphalia
      • Cologne, North Rhine-Westphalia, Germany, 50937
        • Recruiting
        • Universitaetsklinikum Koeln ( Site 1505)
        • Contact:
          • Study Coordinator
          • Phone Number: 004922147839680
    • State of Berlin
      • Berlin, State of Berlin, Germany, 10117
        • Active, not recruiting
        • Campus Charite Mitte Nephrologie und Internistische Intensivmedizin ( Site 1501)
  • Italy
      • Bologna, Italy, 40138
        • Recruiting
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1904)
        • Contact:
          • Study Coordinator
          • Phone Number: +390512143977
      • Genova, Italy, 16132
        • Recruiting
        • Ospedale San Martino ( Site 1900)
        • Contact:
          • Study Coordinator
          • Phone Number: +390105554667
      • Milan, Italy, 20157
        • Recruiting
        • ASST Fatebenefratelli Sacco ( Site 1901)
        • Contact:
          • Study Coordinator
          • Phone Number: +390239042676
      • Pisa, Italy, 56124
        • Recruiting
        • AOU Pisana- Ospedale Cisanello ( Site 1905)
        • Contact:
          • Study Coordinator
          • Phone Number: 39050955431
  • Japan
      • Fukuoka, Japan, 810-8563
        • Recruiting
        • National Hospital Organization Kyushu Medical Center ( Site 2006)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-92-852-0700
      • Kumamoto, Japan, 862-0965
        • Recruiting
        • Kumamoto Chuo Hospital ( Site 2002)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-96-370-3111
    • Chiba
      • Yotsukaidō, Chiba, Japan, 284-0003
        • Recruiting
        • National Hospital Organization Shimoshizu National Hospital ( Site 2007)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-43-422-2511
    • Ibaraki
      • Tsuchiura, Ibaraki, Japan, 300-0062
        • Recruiting
        • Tsuchiura Beryl Clinic ( Site 2009)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-29-835-3002
    • Tokyo
      • Kiyose, Tokyo, Japan, 204-8585
        • Recruiting
        • National Hospital Organization Tokyo National Hospital ( Site 2003)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-42-491-2111
      • Toshimaku, Tokyo, Japan, 171-0014
        • Recruiting
        • Sekino Hospital ( Site 2016)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3986-5501
  • Mexico
      • Chihuahua City, Mexico, 31000
        • Recruiting
        • ICARO Investigaciones en Medicina ( Site 2200)
        • Contact:
          • Study Coordinator
          • Phone Number: +526144106319
      • Veracruz, Mexico, 91910
        • Recruiting
        • Arké SMO S.A de C.V-ARKE SMO S.A. de C.V. ( Site 2210)
        • Contact:
          • Study Coordinator
          • Phone Number: +522295896765
    • Guanajuato
      • León, Guanajuato, Mexico, 37000
        • Recruiting
        • Morales Vargas Centro de Investigacion S. C. ( Site 2206)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 477 716 0714
    • Mexico City
      • Mexico City, Mexico City, Mexico, 14080
        • Recruiting
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran-Departamento de Infectología ( Site 2203)
        • Contact:
          • Study Coordinator
          • Phone Number: +52525554870900
    • Morelos
      • Cuernavaca, Morelos, Mexico, 62100
        • Recruiting
        • Instituto Nacional de Salud Publica ( Site 2205)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 777 102 84 44
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64460
        • Recruiting
        • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Infectologia ( Site 2204)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 8181230812
      • Monterrey, Nuevo León, Mexico, 64718
        • Recruiting
        • Comité de Ética en Investigación del Hospital La Misión ( Site 2207)
        • Contact:
          • Study Coordinator
          • Phone Number: +523330447001
    • Yucatán
      • Mérida, Yucatán, Mexico, 97130
        • Recruiting
        • Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 2202)
        • Contact:
          • Study Coordinator
          • Phone Number: +529991929912
  • New Zealand
      • Auckland, New Zealand, 1010
        • Recruiting
        • Optimal Clinical Trials ( Site 2306)
        • Contact:
          • Study Coordinator
          • Phone Number: +64800737327
      • Auckland, New Zealand, 0600
        • Recruiting
        • Pacific Clinical Research Network West Auckland ( Site 2301)
        • Contact:
          • Study Coordinator
          • Phone Number: +6498830123
      • Auckland, New Zealand, 0932
        • Recruiting
        • Silverdale Medical Limited ( Site 2305)
        • Contact:
          • Study Coordinator
          • Phone Number: +6494279997
      • Auckland, New Zealand, 0627
        • Recruiting
        • Optimal Clinical Trials North ( Site 2308)
        • Contact:
          • Study Coordinator
          • Phone Number: +64800737327
    • Canterbury
      • Christchurch, Canterbury, New Zealand, 8013
        • Active, not recruiting
        • CGM Research Trust ( Site 2307)
    • Tasman District
      • Nelson, Tasman District, New Zealand, 7011
        • Recruiting
        • Pacific Clinical Research Network - Tasman ( Site 2304)
        • Contact:
          • Study Coordinator
          • Phone Number: +64211448740
    • Waikato Region
      • Nawton, Waikato Region, New Zealand, 3200
        • Recruiting
        • Lakeland Clinical Trials Waikato ( Site 2302)
        • Contact:
          • Study Coordinator
          • Phone Number: +64273415595
    • Wellington Region
      • Upper Hutt, Wellington Region, New Zealand, 5018
        • Recruiting
        • Lakeland Clinical Trials Wellington ( Site 2303)
        • Contact:
          • Study Coordinator
          • Phone Number: +6449201800
  • Peru
      • Lima, Peru, 15036
        • Recruiting
        • Clinica Ricardo Palma-Centro de Investigacion de Enfermedades Respiratorias Thorax ( Site 2404)
        • Contact:
          • Study Coordinator
          • Phone Number: 012253445
      • Lima, Peru, 15001
        • Recruiting
        • Via Libre ( Site 2409)
        • Contact:
          • Study Coordinator
          • Phone Number: +5112030099
    • Loreto
      • Iquitos, Loreto, Peru, 16001
        • Recruiting
        • Asociación Civil Selva Amazónica ( Site 2405)
        • Contact:
          • Study Coordinator
          • Phone Number: +51980463994
  • Philippines
    • Cavite
      • Bacoor, Cavite, Philippines, 4102
        • Recruiting
        • Health Index Multispeciality Clinic ( Site 2501)
        • Contact:
          • Study Coordinator
          • Phone Number: 639338190062
    • National Capital Region
      • Makati City, National Capital Region, Philippines, 1218
        • Recruiting
        • Ospital Ng Makati ( Site 2505)
        • Contact:
          • Study Coordinator
          • Phone Number: +63288810983
      • Manila, National Capital Region, Philippines, 1000
        • Recruiting
        • Philippine General Hospital-Department of Medicine ( Site 2504)
        • Contact:
          • Study Coordinator
          • Phone Number: (02) 8554 8400
    • Pampanga
      • San Fernando City, Pampanga, Philippines, 2000
        • Recruiting
        • GreenCity Medical Center ( Site 2503)
        • Contact:
          • Study Coordinator
          • Phone Number: 639222385026
  • Poland
    • Greater Poland Voivodeship
      • Poznan, Greater Poland Voivodeship, Poland, 60-309
        • Recruiting
        • PL Certus ( Site 2613)
        • Contact:
          • Study Coordinator
          • Phone Number: 48734217034
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-048
        • Recruiting
        • In-Vivo Bydgoszcz ( Site 2601)
        • Contact:
          • Study Coordinator
          • Phone Number: 48723351053
    • Lesser Poland Voivodeship
      • Krakow, Lesser Poland Voivodeship, Poland, 31-322
        • Recruiting
        • NZOZ GynCentrum - Oddział Kraków ( Site 2609)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327241012
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 54-239
        • Recruiting
        • Penta Hospitals Przychodnie Wrocław Wejherowska ( Site 2611)
        • Contact:
          • Study Coordinator
          • Phone Number: 48713957541
    • Silesian Voivodeship
      • Bielsko-Biala, Silesian Voivodeship, Poland, 43-300
        • Recruiting
        • NZOZ GynCentrum - Oddział Bielsko-Biała ( Site 2602)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327241012
      • Katowice, Silesian Voivodeship, Poland, 40-156
        • Recruiting
        • Clinical Medical Research ( Site 2604)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327248013
      • Katowice, Silesian Voivodeship, Poland, 40-600
        • Recruiting
        • Holsamed ( Site 2603)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327241012
  • Puerto Rico
      • Humacao, Puerto Rico, 00791
        • Recruiting
        • Investigadores del Este LLC ( Site 4001)
        • Contact:
          • Study Coordinator
          • Phone Number: 787 656 0161
      • San Juan, Puerto Rico, 00921
        • Recruiting
        • Miralles Clinical Research LLC ( Site 4004)
        • Contact:
          • Study Coordinator
          • Phone Number: 787 226 1014
      • San Juan, Puerto Rico, 00926
        • Recruiting
        • MV HEALTH SERVICES LLC ( Site 4003)
        • Contact:
          • Study Coordinator
          • Phone Number: 787 365 2102
  • Romania
      • Bucharest, Romania, 011025
        • Recruiting
        • Centrul Medical SANA ( Site 2704)
        • Contact:
          • Study Coordinator
          • Phone Number: +40212128222
      • Bucharest, Romania, 021105
        • Recruiting
        • National Institute for Infectious Diseases Prof. Dr. Matei Bals ( Site 2706)
        • Contact:
          • Study Coordinator
          • Phone Number: +40212010980
      • Bucharest, Romania, 021105
        • Recruiting
        • National Institute for Infectious Diseases Prof. Dr. Matei Bals ( Site 2707)
        • Contact:
          • Study Coordinator
          • Phone Number: +40212010980
      • Cluj-Napoca, Romania, 400348
        • Recruiting
        • Spitalul Clinic de Boli Infecțioase ( Site 2703)
        • Contact:
          • Study Coordinator
          • Phone Number: +40264594655
      • Constanța, Romania, 900709
        • Recruiting
        • Spitalul Clinic de Boli Infecțioase ( Site 2702)
        • Contact:
          • Study Coordinator
          • Phone Number: +40771696527
    • Bucharest
      • Bucharest, Bucharest, Romania, 030303
        • Recruiting
        • Spitalul Clinic de Boli Infecțioase și Tropicale Victor Babeș ( Site 2701)
        • Contact:
          • Study Coordinator
          • Phone Number: +40213172727
    • Ilfov
      • Baloteşti, Ilfov, Romania, 077015
        • Completed
        • Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu ( Site 2705)
  • South Korea
      • Seoul, South Korea, 02841
        • Recruiting
        • Korea University Anam Hospital ( Site 3001)
        • Contact:
          • Study Coordinator
          • Phone Number: 82-2-920-5096
      • Seoul, South Korea, 07441
        • Recruiting
        • Hallym University Kangnam Sacred Heart Hospital-Internal Medicine ( Site 3003)
        • Contact:
          • Study Coordinator
          • Phone Number: +8228295106
      • Seoul, South Korea, 08308
        • Recruiting
        • Korea University Guro Hospital ( Site 3006)
        • Contact:
          • Study Coordinator
          • Phone Number: +82226263052
    • Kang-won-do
      • Wŏnju, Kang-won-do, South Korea, 26426
        • Recruiting
        • Wonju Severance Christian Hospital-Internal Medicine ( Site 3009)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-33-741-0519
    • Kwangju-Kwangyokshi
      • Gwangju, Kwangju-Kwangyokshi, South Korea, 61469
        • Recruiting
        • Chonnam National University Hospital-Infectious Diseases ( Site 3008)
        • Contact:
          • Study Coordinator
          • Phone Number: 82-62-220-6295
    • Kyonggi-do
      • Ansan-si, Kyonggi-do, South Korea, 15355
        • Recruiting
        • Korea University Ansan Hospital ( Site 3007)
        • Contact:
          • Study Coordinator
          • Phone Number: 82-31-412-5011
    • Kyongsangnam-do
      • Jinju, Kyongsangnam-do, South Korea, 52727
        • Recruiting
        • Gyeongsang National University Hospital ( Site 3005)
        • Contact:
          • Study Coordinator
          • Phone Number: +82557508055
    • Pusan-Kwangyokshi
      • Pusan, Pusan-Kwangyokshi, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital-Internal Medicine ( Site 3010)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-51-240-8592
    • Taegu-Kwangyokshi
      • Deagu, Taegu-Kwangyokshi, South Korea, 41404
        • Recruiting
        • Kyungpook National University Chilgok Hospital-Division of Infectious Diseases ( Site 3002)
        • Contact:
          • Study Coordinator
          • Phone Number: 82-53-200-2616
  • Spain
      • Barcelona, Spain, 08025
        • Recruiting
        • EAP Sardenya ( Site 3109)
        • Contact:
          • Study Coordinator
          • Phone Number: +34935674385
      • Madrid, Spain, 28031
        • Recruiting
        • Hospital Universitario Infanta Leonor ( Site 3110)
        • Contact:
          • Study Coordinator
          • Phone Number: 34911918280
      • Seville, Spain, 41013
        • Recruiting
        • HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 3100)
        • Contact:
          • Study Coordinator
          • Phone Number: +34697958658
    • Alicante
      • Elche, Alicante, Spain, 03202
        • Recruiting
        • Hospital General Universitario de Elche-Infectius Disease ( Site 3105)
        • Contact:
          • Study Coordinator
          • Phone Number: +34966616754
    • Barcelona
      • Badalona, Barcelona, Spain, 08916
        • Recruiting
        • Hospital Germans Trias i Pujol ( Site 3101)
        • Contact:
          • Study Coordinator
          • Phone Number: +34934978349
      • Centelles, Barcelona, Spain, 08540
        • Recruiting
        • EAP Osona Sud - Alt Congost S.L.P ( Site 3107)
        • Contact:
          • Study Coordinator
          • Phone Number: +34938810485
    • Catalonia
      • Barcelona, Catalonia, Spain, 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebron ( Site 3102)
        • Contact:
          • Study Coordinator
          • Phone Number: +34934896090
    • Galicia
      • A Coruña, Galicia, Spain, 15006
        • Recruiting
        • Hospital Universitario de A Coruña ( Site 3112)
        • Contact:
          • Study Coordinator
          • Phone Number: 34 981 17 81 57
    • Murcia
      • Cartagena, Murcia, Spain, 30202
        • Recruiting
        • Hospital Santa Lucia-Medicina Infecciosas ( Site 3106)
        • Contact:
          • Study Coordinator
          • Phone Number: +34968110471
  • Taiwan
      • Kaohsiung City, Taiwan, 813
        • Recruiting
        • Kaohsiung Veterans General Hospital ( Site 3307)
        • Contact:
          • Study Coordinator
          • Phone Number: +88673422121x72187
      • New Taipei City, Taiwan, 23561
        • Recruiting
        • Taipei Medical University - Shuang Ho Hospital ( Site 3308)
        • Contact:
          • Study Coordinator
          • Phone Number: +88622249-0088
      • Taichung, Taiwan, 40705
        • Recruiting
        • Taichung Veterans General Hospital ( Site 3305)
        • Contact:
          • Study Coordinator
          • Phone Number: +886423592525x6523
      • Taipei, Taiwan, 114
        • Recruiting
        • Tri-Service General Hospital ( Site 3304)
        • Contact:
          • Study Coordinator
          • Phone Number: +886287923311x13655
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital ( Site 3301)
        • Contact:
          • Study Coordinator
          • Phone Number: +886-2-2312-3456
      • Taipei, Taiwan, 11696
        • Recruiting
        • Taipei Municipal Wangfang Hospital ( Site 3309)
        • Contact:
          • Study Coordinator
          • Phone Number: +886229307930
      • Taoyuan, Taiwan, 333
        • Recruiting
        • Chang Gung Memorial Hospital - Linkou Branch ( Site 3303)
        • Contact:
          • Study Coordinator
          • Phone Number: +88633281200x8450
    • Kaohsiung
      • Kaoshiung, Kaohsiung, Taiwan, 807
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 3306)
        • Contact:
          • Study Coordinator
          • Phone Number: +88673121101
    • Taoyuan
      • Taoyuan City, Taoyuan, Taiwan, 33004
        • Recruiting
        • Taoyuan General Hospital ( Site 3300)
        • Contact:
          • Study Coordinator
          • Phone Number: +88633699721x8311
  • Thailand
    • Bangkok
      • Bangkok, Bangkok, Thailand, 10700
        • Recruiting
        • Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 3401)
        • Contact:
          • Study Coordinator
          • Phone Number: +6624192977
      • Pathumwan, Bangkok, Thailand, 10330
        • Recruiting
        • HIV Netherlands Australia Thailand Research Collaboration ( Site 3402)
        • Contact:
          • Study Coordinator
          • Phone Number: 02-652-3040
  • Ukraine
      • Kyiv, Ukraine, 02222
        • Recruiting
        • Medlight Clinic ( Site 3548)
        • Contact:
          • Study Coordinator
          • Phone Number: +38 067 46632
      • Kyiv, Ukraine, 03049
        • Recruiting
        • Kyiv Railway Clinical Hospital No.2 of Branch Health Center -Center of Clinical Trials ( Site 3549)
        • Contact:
          • Study Coordinator
          • Phone Number: +380509165888
    • Cherkasy Oblast
      • Cherkasy, Cherkasy Oblast, Ukraine, 18021
        • Recruiting
        • EUROMEDCLINIC ( Site 3517)
        • Contact:
          • Study Coordinator
          • Phone Number: +380966684934
    • Chernihiv Oblast
      • Chernivtsi, Chernihiv Oblast, Ukraine, 58022
        • Recruiting
        • MUNICIPAL NON-PROFIT ENTERPRISE CENTRAL CITY CLINICAL HOSPITAL OF CHERNIVTSI CITY COUNCIL ( Site 3513)
        • Contact:
          • Study Coordinator
          • Phone Number: 380501835097
    • Ivano-Frankivsk Oblast
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76008
        • Recruiting
        • Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 3524)
        • Contact:
          • Study Coordinator
          • Phone Number: +380669779646
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76018
        • Recruiting
        • Regional Phthisiology and Pulmonology Center ( Site 3523)
        • Contact:
          • Study Coordinator
          • Phone Number: +380503383383
    • Kirovohrad Oblast
      • Kropyvnytskyi, Kirovohrad Oblast, Ukraine, 25006
        • Recruiting
        • Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3537)
        • Contact:
          • Study Coordinator
          • Phone Number: +380522 366002
      • Kropyvnytskyi, Kirovohrad Oblast, Ukraine, 25011
        • Recruiting
        • Limited Liability Company Ukrainian Center of Tomotherapy-Clinical Trials Department ( Site 3512)
        • Contact:
          • Study Coordinator
          • Phone Number: +38 095 8718674
    • Kyivska Oblast
      • Kyiv, Kyivska Oblast, Ukraine, 01135
        • Recruiting
        • Medical Center "Harmoniya Krasy" ( Site 3545)
        • Contact:
          • Study Coordinator
          • Phone Number: +380936306646
      • Kyiv, Kyivska Oblast, Ukraine, 04210
        • Recruiting
        • Center of Family Medicine Plus ( Site 3502)
        • Contact:
          • Study Coordinator
          • Phone Number: +380509084116
      • Kyiv, Kyivska Oblast, Ukraine, 02002
        • Recruiting
        • Edelweiss Medics ( Site 3503)
        • Contact:
          • Study Coordinator
          • Phone Number: +380504446557
      • Kyiv, Kyivska Oblast, Ukraine, 04050
        • Recruiting
        • Medical Center of Limited ( Site 3546)
        • Contact:
          • Study Coordinator
          • Phone Number: +380969949971
      • Kyiv, Kyivska Oblast, Ukraine, 03037
        • Recruiting
        • Medbud Clinic-Treatment prevention unit ( Site 3506)
        • Contact:
          • Study Coordinator
          • Phone Number: +380503572250
      • Kyiv, Kyivska Oblast, Ukraine, 02091
        • Recruiting
        • Communal Non-Profit Enterprise "Kyiv City Clinical Hospital #1"-Department of Clinical Research ( Site 3514)
        • Contact:
          • Study Coordinator
          • Phone Number: +38 044 5611708
    • Lviv Oblast
      • Lviv, Lviv Oblast, Ukraine, 79011
        • Recruiting
        • Polyclinic of Communal 4th city clinical hospital ( Site 3501)
        • Contact:
          • Study Coordinator
          • Phone Number: +380504727692
      • Lviv, Lviv Oblast, Ukraine, 79059
        • Suspended
        • Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 3525)
    • Vinnytsia Oblast
      • Vinnytsia, Vinnytsia Oblast, Ukraine, 21001
        • Recruiting
        • University clinic of the National Pirogov Memorial Medical University ( Site 3547)
        • Contact:
          • Study Coordinator
          • Phone Number: +380965363123
      • Vinnytsia, Vinnytsia Oblast, Ukraine, 21029
        • Recruiting
        • Clinic of Scientific and Research Institute of Invalid Rehabilitation of VNMU n.a. M.I.Pyrohov ( Site 3528)
        • Contact:
          • Study Coordinator
          • Phone Number: +380673978046
    • Volyn Oblast
      • Lutsk, Volyn Oblast, Ukraine, 43005
        • Recruiting
        • Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 3530)
        • Contact:
          • Study Coordinator
          • Phone Number: +380958969484
    • Zakarpattia Oblast
      • Uzhhorod, Zakarpattia Oblast, Ukraine, 88000
        • Recruiting
        • Uzhhorod Municipal Multidisciplinary Clinical Hospital of Uzhhorod City Council ( Site 3538)
        • Contact:
          • Study Coordinator
          • Phone Number: 380664959049
  • United Kingdom
    • Bristol, City of
      • Bristol, Bristol, City of, United Kingdom, BS8 2PU
        • Recruiting
        • Whiteladies Medical Group ( Site 3611)
        • Contact:
          • Study Coordinator
          • Phone Number: 01179731201
    • England
      • Exeter, England, United Kingdom, EX2 5DW
        • Recruiting
        • Royal Devon & Exeter Hospital ( Site 3604)
        • Contact:
          • Study Coordinator
          • Phone Number: 01392411611
    • Newcastle Upon Tyne
      • Newcastle, Newcastle Upon Tyne, United Kingdom, NE1 4LP
        • Recruiting
        • Royal Victoria Infirmary ( Site 3608)
        • Contact:
          • Study Coordinator
          • Phone Number: +441912336161
    • Norfolk
      • Norwich, Norfolk, United Kingdom, NR3 3DL
        • Recruiting
        • Oak Street Medical Practice ( Site 3612)
        • Contact:
          • Study Coordinator
          • Phone Number: +441603613431
      • Norwich, Norfolk, United Kingdom, NR1 1RB
        • Recruiting
        • Norwich Practices Health Centre ( Site 3605)
        • Contact:
          • Study Coordinator
          • Phone Number: +4407552431271
    • Northamptonshire
      • Northamptonshire, Northamptonshire, United Kingdom, NN17 2UR
        • Recruiting
        • Lakeside Surgery ( Site 3600)
        • Contact:
          • Study Coordinator
          • Phone Number: +441536748282
    • Oxfordshire
      • Bicester, Oxfordshire, United Kingdom, OX26 6AT
        • Recruiting
        • Bicester Health Centre ( Site 3609)
        • Contact:
          • Study Coordinator
          • Phone Number: 01869 249333
      • Oxford, Oxfordshire, United Kingdom, OX16 9AD
        • Recruiting
        • Banbury Cross Health Centre ( Site 3610)
        • Contact:
          • Study Coordinator
    • Somerset
      • Somerset, Somerset, United Kingdom, TA11 7PB
        • Recruiting
        • Buttercross Health Centre ( Site 3606)
        • Contact:
          • Study Coordinator
          • Phone Number: +441458272473
  • United States
    • Alabama
      • Cullman, Alabama, United States, 35055
        • Completed
        • Cullman Clinical Trials ( Site 3813)
    • Arizona
      • Paradise Valley, Arizona, United States, 85253
        • Recruiting
        • Helios Clinical Research ( Site 3826)
        • Contact:
          • Study Coordinator
          • Phone Number: 480-659-0448
      • Phoenix, Arizona, United States, 85051
        • Completed
        • Absolute Clinical Research ( Site 3709)
    • California
      • Castroville, California, United States, 95012
        • Recruiting
        • Clinica de Salud del Valle de Salinas ( Site 3825)
        • Contact:
          • Study Coordinator
          • Phone Number: 805-483-1185
      • Fullerton, California, United States, 92835
        • Completed
        • Ascada Health PC dba Ascada Research ( Site 3750)
      • Los Alamitos, California, United States, 90720
        • Recruiting
        • Pacific Clinical Studies ( Site 3827)
        • Contact:
          • Study Coordinator
          • Phone Number: 5625980600x205
      • Northridge, California, United States, 91325
        • Recruiting
        • Valley Clinical Trials, Inc. ( Site 3707)
        • Contact:
          • Study Coordinator
          • Phone Number: 818-280-4220
      • Oxnard, California, United States, 93030
        • Recruiting
        • FOMAT Medical Research ( Site 3720)
        • Contact:
          • Study Coordinator
          • Phone Number: 805-483-1185
      • San Diego, California, United States, 91208
        • Recruiting
        • Paradigm Clinical Research, LLC ( Site 3785)
        • Contact:
          • Study Coordinator
          • Phone Number: 858274426
      • San Francisco, California, United States, 94102
        • Recruiting
        • Optimus Medical ( Site 3817)
        • Contact:
          • Study Coordinator
          • Phone Number: 415-518-1292
      • Westlake Village, California, United States, 91361
        • Recruiting
        • Millennium Clinical Trials ( Site 3758)
        • Contact:
          • Study Coordinator
          • Phone Number: 805-496-3322
    • Colorado
      • Wheat Ridge, Colorado, United States, 80033
        • Recruiting
        • Paradigm Clinical Research Centers, Inc ( Site 3718)
        • Contact:
          • Study Coordinator
          • Phone Number: 303-463-1947
    • Florida
      • Boynton Beach, Florida, United States, 33436
        • Recruiting
        • Encore Medical Research of Boynton Beach ( Site 3701)
        • Contact:
          • Study Coordinator
          • Phone Number: 561-774-8799
      • Coral Gables, Florida, United States, 33134
        • Recruiting
        • Prestige Clinical Research Center ( Site 3722)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-907-6960
      • Homestead, Florida, United States, 33030
        • Recruiting
        • Prestige Clinical Research ( Site 3830)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-907-6961
      • Largo, Florida, United States, 33777
        • Recruiting
        • Accel Research Sites Network - St. Pete-Largo Clinical Research Unit ( Site 3779)
        • Contact:
          • Study Coordinator
          • Phone Number: 727-347-8839
      • Leesburg, Florida, United States, 34748
        • Recruiting
        • Clinical Site Partners, LLC dba Flourish Research ( Site 3717)
        • Contact:
          • Study Coordinator
          • Phone Number: 325-435-7240
      • Loxahatchee Groves, Florida, United States, 33470
        • Active, not recruiting
        • Advanced Pulmonary Research Institute ( Site 3781)
      • Miami, Florida, United States, 33125
        • Recruiting
        • Southern Clinical Research ( Site 3773)
        • Contact:
          • Study Coordinator
          • Phone Number: 844-312-1727
      • Miami, Florida, United States, 33176
        • Recruiting
        • Reed Medical Research ( Site 3761)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-413-0531
      • Miami, Florida, United States, 33143
        • Recruiting
        • Florida Pharmaceutical Research and Associates ( Site 3763)
        • Contact:
          • Study Coordinator
          • Phone Number: 786-254-7296
      • Miami, Florida, United States, 33144
        • Recruiting
        • Bio-Medical Research LLC ( Site 3804)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-671-3686
      • Miami, Florida, United States, 33155
        • Recruiting
        • Miami Clinical Research ( Site 3729)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-433-6496
      • Miami, Florida, United States, 33144
        • Completed
        • Bright Research Center ( Site 3746)
      • Miami Lakes, Florida, United States, 33014
        • Recruiting
        • Panax Clinical Research ( Site 3803)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-698-4500
      • Miami Lakes, Florida, United States, 33014
        • Recruiting
        • Palm Springs Community Health Center ( Site 3757)
        • Contact:
          • Study Coordinator
          • Phone Number: 786-334-6675
      • Miami Lakes, Florida, United States, 33016
        • Recruiting
        • Indago Research and Health Center Inc ( Site 3714)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-825-6588
      • Orlando, Florida, United States, 32807
        • Recruiting
        • Combined Research Orlando Phase I-IV ( Site 3797)
        • Contact:
          • Study Coordinator
          • Phone Number: 407-440-4493
      • Port Saint Lucie, Florida, United States, 34952
        • Recruiting
        • CDC Research Institute ( Site 3716)
        • Contact:
          • Study Coordinator
          • Phone Number: 772-807-1636
      • Tampa, Florida, United States, 33603
        • Recruiting
        • New Tampa Health ( Site 3764)
        • Contact:
          • Study Coordinator
          • Phone Number: 813-440-6355
      • Tampa, Florida, United States, 33614
        • Recruiting
        • Precision Research Center ( Site 3704)
        • Contact:
          • Study Coordinator
          • Phone Number: 813-513-2365
      • Tampa, Florida, United States, 33607
        • Recruiting
        • Clinical Research Trials of Florida ( Site 3703)
        • Contact:
          • Study Coordinator
          • Phone Number: 813-873-8102
      • Weston, Florida, United States, 33331
        • Completed
        • Encore Medical Research - Weston ( Site 3708)
    • Georgia
      • Lawrenceville, Georgia, United States, 30046
        • Recruiting
        • Balanced Life Health Care Solutions/SKYCRNG ( Site 3713)
        • Contact:
          • Study Coordinator
          • Phone Number: 770-696-4541
      • Snellville, Georgia, United States, 30078
        • Recruiting
        • Renew Health Clinical Research ( Site 3760)
        • Contact:
          • Study Coordinator
          • Phone Number: 706-223-3560
      • Union City, Georgia, United States, 30291
        • Completed
        • Rophe Adult and Pediatric Medicine/SKYCRNG ( Site 3816)
    • Idaho
      • Boise, Idaho, United States, 83709
        • Active, not recruiting
        • Paradigm Clinical Research - Boise ( Site 3841)
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Recruiting
        • Rush University Medical Center ( Site 3748)
        • Contact:
          • Study Coordinator
          • Phone Number: 312-942-5987
      • Lombard, Illinois, United States, 60148
        • Recruiting
        • Duly Health and Care ( Site 3799)
        • Contact:
          • Study Coordinator
          • Phone Number: 630-545-7760
    • Kentucky
      • Louisville, Kentucky, United States, 40202
        • Recruiting
        • University of Louisville School of Medicine ( Site 3706)
        • Contact:
          • Study Coordinator
          • Phone Number: 502-852-3836
    • Louisiana
      • Natchitoches, Louisiana, United States, 71457
        • Completed
        • Barnum Medical Research ( Site 3828)
    • Maryland
      • Annapolis, Maryland, United States, 21401
        • Recruiting
        • Annapolis Internal Medicine - CCT Research ( Site 3700)
        • Contact:
          • Study Coordinator
          • Phone Number: 410-824-1005
      • Columbia, Maryland, United States, 21045
        • Recruiting
        • Kur Research - Columbia Medical ( Site 3767)
        • Contact:
          • Study Coordinator
          • Phone Number: 410-964-8522
    • Michigan
      • Dearborn, Michigan, United States, 48126
        • Completed
        • Revival Research Institute, LLC ( Site 3835)
      • Farmington Hills, Michigan, United States, 48334
        • Completed
        • Michigan Center of Medical Research (MICHMER) ( Site 3734)
      • Grosse Pointe Woods, Michigan, United States, 48236
        • Recruiting
        • Henry Ford St John TM Center for Infectious Disease Research ( Site 3766)
        • Contact:
          • Study Coordinator
          • Phone Number: 313-343-6311
    • Minnesota
      • Mankato, Minnesota, United States, 56001
        • Recruiting
        • Mankato Clinic ( Site 3842)
        • Contact:
          • Study Coordinator
          • Phone Number: 507-625-1811
    • Mississippi
      • Fayette, Mississippi, United States, 39069
        • Recruiting
        • Prime Health and Wellness/SKYCRNG ( Site 3726)
        • Contact:
          • Study Coordinator
          • Phone Number: 601-786-8655
      • Ridgeland, Mississippi, United States, 39157
        • Recruiting
        • SKY Integrative Medical Center/SKYCRNG ( Site 3740)
        • Contact:
          • Study Coordinator
          • Phone Number: 601-617-7717
    • Nevada
      • Carson City, Nevada, United States, 89706
        • Recruiting
        • Nevada Health Centers ( Site 3840)
        • Contact:
          • Study Coordinator
          • Phone Number: 770-200-9775
      • Las Vegas, Nevada, United States, 89106
        • Recruiting
        • WR-CRCN, LLC ( Site 3818)
        • Contact:
          • Study Coordinator
          • Phone Number: 702-893-8968
    • New Jersey
      • Newark, New Jersey, United States, 07102
        • Recruiting
        • Saint Michael's Medical Center ( Site 3808)
        • Contact:
          • Study Coordinator
          • Phone Number: 973-877-5162
      • Teaneck, New Jersey, United States, 07666
        • Recruiting
        • Holy Name Medical Center ( Site 3807)
        • Contact:
          • Study Coordinator
          • Phone Number: 201-833-3000
    • New York
      • New York, New York, United States, 10065
        • Recruiting
        • Weill Cornell Medical College ( Site 3814)
        • Contact:
          • Study Coordinator
          • Phone Number: 212-746-7587
      • The Bronx, New York, United States, 10456
        • Recruiting
        • Prime Global Research ( Site 3731)
        • Contact:
          • Study Coordinator
          • Phone Number: 718-676-9444
    • North Carolina
      • Charlotte, North Carolina, United States, 28277
        • Recruiting
        • OnSite Clinical Solutions ( Site 3784)
        • Contact:
          • Study Coordinator
          • Phone Number: 800-785-3150
      • Monroe, North Carolina, United States, 28112
        • Recruiting
        • Monroe Biomedical Research ( Site 3732)
        • Contact:
          • Study Coordinator
          • Phone Number: 704-283-7359
      • Mount Airy, North Carolina, United States, 27030
        • Recruiting
        • IMA Clinical Research Mount Airy ( Site 3745)
        • Contact:
          • Study Coordinator
          • Phone Number: 336-415-5507
    • Ohio
      • Beavercreek, Ohio, United States, 45431
        • Active, not recruiting
        • Research Innovations, LLC ( Site 3712)
    • South Carolina
      • Columbia, South Carolina, United States, 29205
        • Active, not recruiting
        • Midlands Neurology & Pain Associates ( Site 3751)
    • Tennessee
      • Jackson, Tennessee, United States, 38305
        • Recruiting
        • Helios Clinical Research - JAC ( Site 3833)
        • Contact:
          • Study Coordinator
          • Phone Number: 731-431-5027
    • Texas
      • Conroe, Texas, United States, 77384
        • Recruiting
        • Javara - Privia Medical Group Gulf Coast - The Woodlands HWH ( Site 3837)
        • Contact:
          • Study Coordinator
          • Phone Number: 281-639-5061
      • Corpus Christi, Texas, United States, 78404
        • Recruiting
        • South Texas Clinical Research ( Site 3815)
        • Contact:
          • Study Coordinator
          • Phone Number: 361-288-4668
      • Forney, Texas, United States, 75126
        • Active, not recruiting
        • Care United Research, LLC ( Site 3747)
      • Houston, Texas, United States, 77030
        • Recruiting
        • Houston Methodist Hospital ( Site 3800)
        • Contact:
          • Study Coordinator
          • Phone Number: 713-441-3250
      • Houston, Texas, United States, 77030
        • Recruiting
        • MD Anderson ( Site 3843)
        • Contact:
          • Study Coordinator
          • Phone Number: 713-792-6830
      • Laredo, Texas, United States, 78041
        • Recruiting
        • Andres Garcia Zuniga, M.D., P.A. ( Site 3782)
        • Contact:
          • Study Coordinator
          • Phone Number: 956-307-4280
      • Pearland, Texas, United States, 77584
        • Recruiting
        • LinQ Research ( Site 3824)
        • Contact:
          • Study Coordinator
          • Phone Number: 281-916-4220
      • Victoria, Texas, United States, 77901
        • Recruiting
        • Crossroads Clinical Research-Family Practice ( Site 3739)
        • Contact:
          • Study Coordinator
          • Phone Number: 361-574-7800
    • Virginia
      • Hampton, Virginia, United States, 23666
        • Recruiting
        • Velocity Clinical Research - Hampton ( Site 3744)
        • Contact:
          • Study Coordinator
          • Phone Number: 757-520-5111
    • Washington
      • Redmond, Washington, United States, 98052
        • Recruiting
        • Eastside Research Associates ( Site 3727)
        • Contact:
          • Study Coordinator
          • Phone Number: 425-869-6828

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

  • Is an individual of any sex/gender, ≥18 years of age
  • Has documentation of SARS-CoV-2 infection with sample collection ≤4 days prior to randomization
  • Has initial onset of signs/symptoms attributable to COVID-19 for ≤4 days prior to the day of randomization and ≥2 of the following signs/symptoms attributable to COVID-19 on the day of randomization: cough, sore throat, nasal congestion, shortness of breath or difficulty breathing with exertion, muscle or body aches, fatigue, fever >38.0°C or chills, nausea or vomiting or diarrhea, change in sense of smell or change in sense of taste, or headache

  • Has ≥1 of the following characteristics or medical conditions associated with the highest risk of severe illness from COVID-19:

    • Advanced age of ≥75 years of age
    • Immunocompromised
    • Neurocognitive or physical disability
    • Has ≥3 characteristics or medical conditions which increase the risk of severe illness due to COVID-19 (e.g., chronic lung disease, obesity with body mass index (BMI) ≥35, diabetes)

  • Is unable or unwilling to receive treatment with nirmatrelvir/ritonavir (NMV/r) due to 1 or more of the following:

    • Is receiving drug(s) highly dependent on cytochrome P450 3A (CYP3A) for clearance and for which elevated concentrations are associated with serious and/or life-threatening consequences or drug(s) with a clinically significant drug-drug interaction for which co-administration is not possible
    • Is receiving potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance
    • Has severe hepatic impairment
    • Has experienced prior adverse reactions or hepatotoxicity to NMV/r that would preclude future use
    • Has known or suspected NMV/r resistance
    • Has uncontrolled HIV infection
    • NMV/r is not approved/authorized in the participant's country or it is not accessible to participant (e.g., drug shortage)
    • Is unwilling to receive treatment with NMV/r

Inclusion note: Participants may receive remdesivir as standard of care in addition to molnupiravir or placebo. If remdesivir is available and clinically appropriate per local clinical practice, investigators will aim to ensure that those who are most vulnerable to severe COVID-19 receive timely access to remdesivir as standard of care on this study.

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

  • Is currently hospitalized or is expected to need hospitalization for COVID-19 imminently
  • Has received or plans to receive SARS-CoV-2 directed oral antivirals or monoclonal antibodies for current episode of COVID-19 (other than study intervention and, if applicable, remdesivir as standard of care)

  • Has ≥1 of the following signs/symptoms that are attributable to severe or critical COVID-19:

    • Shortness of breath at rest
    • Respiratory rate ≥30 breaths per minute
    • Heart rate ≥125 beats per minute
    • Peripheral oxygen saturation (SpO2) ≤93% on room air or on supplemental oxygen for a reason other than COVID-19 which has not increased since onset of COVID-19 signs/symptoms
    • New or increasing need for supplemental oxygen: receiving >4 liters/minute supplemental oxygen due to COVID-19 OR on supplemental oxygen for a reason other than COVID-19 which has increased due to COVID-19
  • Has received a COVID-19 vaccine within 30 days prior to randomization
  • Has a history of confirmed influenza, respiratory syncytial virus (RSV), or SARS-CoV-2 infection (with or without symptoms; excluding current infection) within 30 days prior to randomization
  • Has known or suspected hypersensitivity to active or inactive ingredients of molnupiravir

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Molnupiravir
Participants will receive 800 mg molnupiravir orally every 12 hours for 5 days (a total of 10 consecutive doses)
Drug: Molnupiravir
Molnupiravir administered orally as two 400 mg film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)
Other Names:
  • MK-4482
  • LAGEVRIO®
Placebo Comparator: Placebo
Participants will receive molnupiravir-matching placebo orally every 12 hours for 5 days (a total of 10 consecutive doses)
Drug: Placebo
Molnupiravir-matching placebo administered orally as two film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants Who Experienced One or More of Following Through Day 29: All-cause Hospitalization, All-cause Mortality, or Covid-19-related Medically-attended Visit (MAV)
Time Frame: Up to 29 days
Hospitalization is defined as ≥24 hours of acute care in a hospital or similar acute care facility, including emergency rooms or facilities created to address hospitalization needs specifically for COVID-19. Hospitalization and death may be due to any cause. An MAV is defined as any unscheduled, nonroutine healthcare visit where the participant is evaluated by a licensed (according to local/national guidelines) healthcare provider. As prespecified by the protocol, the percentage of participants who experience ONE OR MORE of these 3 events (hospitalization, death, or COVID-19-related MAV) occurring from randomization through Day 29 will be presented.
Up to 29 days
Percentage of Participants Who Experienced an Adverse Event (AE)
Time Frame: Up to approximately 5 months
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The percentage of participants with at least 1 AE will be presented.
Up to approximately 5 months
Percentage of Participants Who Discontinued Study Intervention Due to AE
Time Frame: Up to approximately 5 days
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The percentage of participants who discontinue study intervention due to an AE will be presented.
Up to approximately 5 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of Participants Who Experienced One or More of Following Through Day 29: All-cause Hospitalization or All-cause Mortality
Time Frame: Up to 29 days
Hospitalization is defined as ≥24 hours of acute care in a hospital or similar acute care facility, including emergency rooms or facilities created to address hospitalization needs specifically for COVID-19. Hospitalization and death may be due to any cause. As prespecified by the protocol, the percentage of participants who experience hospitalization AND/OR death occurring from randomization through Day 29 will be presented.
Up to 29 days
Percentage of Participants With Clinically Important Medical Interventions (CIMI) Associated with COVID-19-related MAV or COVID-19-related Hospitalization Through Day 29
Time Frame: Up to 29 days
CIMIs were prespecified by the protocol and include, but are not limited to, supplemental oxygen therapy, IV fluid administration, and nebulizer treatment. An MAV is defined as any unscheduled, nonroutine healthcare visit where the participant is evaluated by a licensed (according to local/national guidelines) healthcare provider. Hospitalization is defined as ≥24 hours of acute care in a hospital or similar acute care facility, including emergency rooms or facilities created to address hospitalization needs specifically for COVID-19. The percentage of participants with CIMIs associated with a COVID-19-related MAV AND/OR a COVID-19-related hospitalization through Day 29 will be reported.
Up to 29 days
Time to Sustained Alleviation (without relapse) of all selected 8 (5 prespecified and 3 determined by baseline prevalence), self-reported COVID-19 signs/symptoms
Time Frame: Up to 29 days
Time to sustained alleviation without relapse is defined as the number of days from randomization to the first of 2 consecutive days when alleviation (lessening of symptoms) is demonstrated, collectively, for all 8 selected COVID-19-related sign/symptoms. Participants who experience sustained alleviation for 2 consecutive days must not relapse in any of the 8 signs/symptoms before Day 29. The time to sustained alleviation without relapse of all 8 selected COVID-19-related signs/symptoms from randomization through Day 29 will be presented.
Up to 29 days
Change from Baseline in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA Titer
Time Frame: Day 1 (baseline) and up to Day 29
SARS-CoV-2 RNA titer (viral load) will be measured by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) of samples from nasopharyngeal (NP) swabs, and the mean change from baseline will be presented.
Day 1 (baseline) and up to Day 29
Percentage of Participants with Undetectable SARS-CoV-2 RNA
Time Frame: Up to 29 days
SARS-CoV-2 RNA (viral load) will be measured by quantitative RT-PCR of samples from NP swabs, and the percentage of participants with undetectable (i.e., below the lower limit of quantification) SARS-CoV-2 RNA (viral load) will be presented.
Up to 29 days
Time to Sustained Alleviation (without relapse) of all 15 self-reported COVID-19 signs/symptoms through Day 29
Time Frame: Up to 29 days
Time to sustained alleviation without relapse is defined as the number of days from randomization to the first of 2 consecutive days when alleviation (lessening of symptoms) is demonstrated, collectively, for all 15 COVID-19-related sign/symptoms. Participants who experience sustained alleviation after 2 consecutive days must not relapse in any of the 15 signs/symptoms before Day 29. The time to sustained alleviation without relapse of all 15 COVID-19-related signs/symptoms from randomization through Day 29 will be presented.
Up to 29 days
Time to Sustained Resolution Without Relapse of all 8 (5 prespecified and 3 determined by baseline prevalence) self-reported COVID-19 signs/symptoms through Day 29
Time Frame: Up to 29 days
Time to sustained resolution without relapse is defined as the number of days from randomization to the first of 2 consecutive days when resolution (having no symptoms or only mild symptoms) is demonstrated, collectively, for all 8 selected COVID-19-related sign/symptoms. Participants who experience sustained resolution after 2 consecutive days must not relapse in any of the 8 signs/symptoms before Day 29. The time to sustained resolution without relapse of all 8 selected COVID-19-related signs/symptoms from randomization through Day 29 will be presented.
Up to 29 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Merck Sharp & Dohme LLC

Investigators

  • Study Director: Medical Director, Merck Sharp & Dohme LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 2, 2024

Primary Completion (Estimated)

January 26, 2031

Study Completion (Estimated)

January 26, 2031

Study Registration Dates

First Submitted

October 30, 2024

First Submitted That Met QC Criteria

October 30, 2024

First Posted (Actual)

October 31, 2024

Study Record Updates

Last Update Posted (Actual)

September 14, 2026

Last Update Submitted That Met QC Criteria

September 11, 2026

Last Verified

September 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 4482-023
  • 2023 (U.S. NIH Grant/Contract: GRAMMY Museum Foundation)
  • U1111-1295-4678 (Registry Identifier: UTN)
  • MK-4482-023 (Other Identifier: MSD)
  • 2023-507227-36-00 (Registry Identifier: EU CT)
  • jRCT2031250022 (Registry Identifier: Japan Registry of Clinical Trials (jRCT))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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