Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease (FourLight-3)

May 18, 2026 updated by: Pfizer

AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)

The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer:

HR-positive (breast cancer cells that need estrogen or progesterone to grow)
HER2-negative (cells that have a small amount or none of a protein called HER2 on their surface);
locally advanced (that has spread from where it started to nearby tissue or lymph nodes) or metastatic disease (the spread of cancer to other places in the body)
who have not received any prior systemic anti-cancer treatment for advanced/metastatic disease.

Approximately half of the participants will receive PF-07220060 plus letrozole while the other half of participants will receive the investigator's choice of treatment plus letrozole.

The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.

Study Overview

Status

Active, not recruiting

Conditions

Breast Cancer

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

1035

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, C1426ABP
    - Fundación Respirar
  - Buenos Aires, Argentina, 1414
    - Centro Medico Fleischer
  - La Rioja, Argentina, F5300COE
    - Fundación CORI para la Investigación y Prevención del Cáncer
  - San Juan, Argentina, 5400
    - COE (Centro Oncológico de Excelencia)
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1015ABO
    - Organizacion Medica de Investigacion
Australia
- Queensland
  - Douglas, Queensland, Australia, 4814
    - Townsville University Hospital
  - Woolloongabba, Queensland, Australia, 4102
    - Princess Alexandra Hospital
- Victoria
  - Capel Sound, Victoria, Australia, 3940
    - Rosebud Hospital
  - Melbourne, Victoria, Australia, 3000
    - Peter MacCallum Cancer Centre
  - Parkville, Victoria, Australia, 3052
    - Royal Melbourne Hospital
Belgium
- Antwerpen
  - Edegem, Antwerpen, Belgium, 2650
    - Antwerp University Hospital
- Bruxelles-capitale, Région de
  - Anderlecht, Bruxelles-capitale, Région de, Belgium, 1070
    - Institut Jules Bordet
- Hainaut
  - Gilly, Hainaut, Belgium, 6060
    - Grand Hôpital de Charleroi
- Oost-vlaanderen
  - Ghent, Oost-vlaanderen, Belgium, 9000
    - AZ Maria Middelares
- Vlaams-brabant
  - Leuven, Vlaams-brabant, Belgium, 3000
    - UZ Leuven
Brazil
- - São Paulo, Brazil, 04014-002
    - IBCC - Núcleo de Pesquisa e Ensino
  - São Paulo, Brazil, 03102-002
    - IBCC - Instituto Brasileiro de Controle do Cancer
- Ceará
  - Fortaleza, Ceará, Brazil, 60336232
    - Crio - Centro Regional Integrado de Oncologia
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29043-260
    - Hospital Santa Rita de Cassia
- Federal District
  - Brasília, Federal District, Brazil, 71.635-610
    - Hospital Brasilia
- Minas Gerais
  - Passos, Minas Gerais, Brazil, 37904-020
    - Santa Casa de Misericordia de Passos
- Pernambuco
  - Recife, Pernambuco, Brazil, 52010-075
    - Real Hospital Portugues
- Rio Grande do Sul
  - Ijuí, Rio Grande do Sul, Brazil, 98700-000
    - ONCOSITE - Centro de Pesquisa Clinica em Oncologia
  - Passo Fundo, Rio Grande do Sul, Brazil, 99010-090
    - Hospital São Vicente de Paulo
  - Passo Fundo, Rio Grande do Sul, Brazil, 99010-080
    - Associação Hospitalar Beneficente São Vicente de Paulo
- São Paulo
  - Santo André, São Paulo, Brazil, 09060-650
    - Faculdade de Medicina do ABC
  - São Paulo, São Paulo, Brazil, 01327-001
    - Hospital Alemao Oswaldo Cruz
Bulgaria
- - Burgas, Bulgaria, 8000
    - Complex Oncology Center - Burgas
  - Gabrovo, Bulgaria, 5300
    - Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD
  - Plovdiv, Bulgaria, 4004
    - Complex Oncology Center - Plovdiv EOOD
  - Sofia, Bulgaria, 1330
    - MHAT for Women's Health Nadezhda
  - Sofia, Bulgaria, 1756
    - University Specialized Hospital for Active Treatment of Oncology EAD
- Sofia (stolitsa)
  - Sofia, Sofia (stolitsa), Bulgaria, 1632
    - Multiprofile Hospital for Active Treatment Serdikamed EOOD
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 5G2
    - Arthur J.E. Child Comprehensive Cancer Centre
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- New Brunswick
  - Fredericton, New Brunswick, Canada, E3B 5N5
    - Dr. Everett Chalmers Regional Hospital
- Ontario
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Cancer Centre
  - Toronto, Ontario, Canada, M4N 3M5
    - Sunnybrook Research Institute
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - CIUSSS- saguenay-Lac-Saint-Jean
China
- Anhui
  - Hefei, Anhui, China, 230031
    - Anhui Provincial Cancer Hospital
- Beijing Municipality
  - Beijing, Beijing Municipality, China, 100142
    - Beijing Cancer Hospital
  - Beijing, Beijing Municipality, China, 100044
    - Peking University People's Hospital
  - Beijing, Beijing Municipality, China, 100021
    - Cancer Hospital Chinese Academy of Medical Science
- Fujian
  - Fuzhou, Fujian, China, 350001
    - Fujian Medical University Union Hospital
- Guangdong
  - Foshan, Guangdong, China, 528000
    - The First People's Hospital of Foshan
  - Guangzhou, Guangdong, China
    - Sun yat-sen University Cancer Center
  - Guangzhou, Guangdong, China, 510060
    - Sun yat-sen University Cancer Center
- Guangxi
  - Nanning, Guangxi, China, 530021
    - Guangxi Medical University Affiliated Tumor Hospital
- Heilongjiang
  - Harbin, Heilongjiang, China, 150081
    - Harbin Medical University Cancer Hospital
- Hubei
  - Wuhan, Hubei, China, 430079
    - Hubei Cancer Hospital
  - Wuhan, Hubei, China, 430030
    - Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
  - Wuhan, Hubei, China, 430022
    - Wuhan Union Hospital Cancer Center
- Hunan
  - Changsha, Hunan, China, 410013
    - Hunan Cancer Hospital
- Jiangsu
  - Nanjing, Jiangsu, China, 210031
    - Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
- Jilin
  - Changchun, Jilin, China, 130021
    - The First Hospital of Jilin University
- Liaoning
  - Dalian, Liaoning, China, 116023
    - The 2nd Affiliated Hospital of Dalian Medical University
  - Shenyang, Liaoning, China, 110015
    - The First Hospital of China Medical University
- Shaanxi
  - Xi'an, Shaanxi, China, 710061
    - The First Affiliated Hospital of Xi'an Jiaotong University
  - Xi'an, Shaanxi, China, 710004
    - The Second Affiliated Hospital of Xi'an Jiaotong University
- Shandong
  - Jinan, Shandong, China, 250117
    - Shandong Cancer Hospital
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, China, 200032
    - Fudan University Shanghai Cancer Center
- Zhejiang
  - Hangzhou, Zhejiang, China, 310022
    - Zhejiang Cancer Hospital
  - Hangzhou, Zhejiang, China, 310016
    - Sir Run Run Shaw Hospital
  - Linhai, Zhejiang, China, 317004
    - Taizhou Hospital of Zhejiang Province
  - Wenzhou, Zhejiang, China, 325000
    - The First Affiliated Hospital of Wenzhou Medical University
Czechia
- - Nový Jičín, Czechia, 741 01
    - Nemocnice AGEL Nový Jičín a.s.
  - Prague, Czechia, 100 34
    - Fakultni nemocnice Kralovske Vinohrady
- Brno-město
  - Brno, Brno-město, Czechia, 656 53
    - Masarykuv onkologicky ustav
  - Brno, Brno-město, Czechia, 625 00
    - Fakultní nemocnice Brno Bohunice
- Praha 4
  - Prague, Praha 4, Czechia, 14059
    - Fakultni Thomayerova nemocnice
Denmark
- Capital Region
  - Copenhagen, Capital Region, Denmark, 2100
    - Rigshospitalet
- Central Jutland
  - Aarhus, Central Jutland, Denmark, 8200
    - Aarhus Universitetshospital, Skejby
- Region Syddanmark
  - Esbjerg, Region Syddanmark, Denmark, 6700
    - Esbjerg sygehus, Syddansk Universitetshospital
  - Odense, Region Syddanmark, Denmark, 5000
    - Odense Universitetshospital
  - Sønderborg, Region Syddanmark, Denmark, 6400
    - Sygehus Soenderjylland
Finland
- - Pori, Finland, 28500
    - Satakunnan Keskussairaala
- Pirkanmaa
  - Tampere, Pirkanmaa, Finland, 33520
    - Tampereen yliopistollinen sairaala
- Southwest Finland
  - Turku, Southwest Finland, Finland, 20520
    - Turku University Hospital
- Uusimaa
  - Helsinki, Uusimaa, Finland, 00029
    - Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
France
- - La Roche-sur-Yon, France, 85925
    - CHD Vendee
- Aquitaine
  - Bayonne, Aquitaine, France, 64100
    - Centre Hospitalier de la Côte Basque
  - Bordeaux, Aquitaine, France, 33076
    - Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
- Hauts-de-France
  - Lille, Hauts-de-France, France, 59020
    - Centre Oscar Lambret
- Hauts-de-seine
  - Saint-Cloud, Hauts-de-seine, France, 92210
    - Institut Curie - site Saint-Cloud
- Ille-et-vilaine
  - Rennes, Ille-et-vilaine, France, 35042
    - Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
- Languedoc-roussillon
  - Montpellier, Languedoc-roussillon, France, 34070
    - Centre de Cancerologie du Grand Montpellier
- Loire-atlantique
  - Saint-Herblain, Loire-atlantique, France, 44805
    - Institut de Cancérologie de l'Ouest
- Maine-et-loire
  - Angers, Maine-et-loire, France, 49055
    - Institut de Cancérologie de l'Ouest
- Rhône
  - Pierre-Bénite, Rhône, France, 69310
    - Centre Hospitalier Lyon Sud
- Seine-maritime
  - Rouen, Seine-maritime, France, 76038
    - Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
- Val-de-marne
  - Villejuif, Val-de-marne, France, 94800
    - Gustave Roussy
- Île-de-France Region
  - Créteil, Île-de-France Region, France, 94010
    - Henri Mondor Hospital
Germany
- - Dresden, Germany, 01307
    - Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
  - Velbert, Germany, 42551
    - MVZ für Hämatologie und Onkologie
- Baden-Wurttemberg
  - Ravensburg, Baden-Wurttemberg, Germany, 88212
    - MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum
- Bavaria
  - Erlangen, Bavaria, Germany, 91054
    - Universitaetsklinikum Erlangen
- Saxony
  - Dresden, Saxony, Germany, 01307
    - Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
  - Leipzig, Saxony, Germany, 04103
    - Universitätsklinikum Leipzig
Greece
- - Athens, Greece, 115 28
    - Aretaieio Hospital
- Attikí
  - Athens, Attikí, Greece, 115 22
    - AGIOS SAVVAS General Anticancer Oncological Hospital
Hungary
- - Budapest, Hungary, 1122
    - Orszagos Onkologiai Intezet
  - Budapest, Hungary, 1145
    - Budapesti Uzsoki Utcai Kórház
- Bekes County
  - Gyula, Bekes County, Hungary, 5700
    - Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
- Borsod-Abauj Zemplen county
  - Miskolc, Borsod-Abauj Zemplen county, Hungary, 3526
    - Borsod-Abaúj-Zemplén Vármegyei Központi Kórház és Egyetemi Oktatókórház
- Szabolcs-Szatmár-Bereg
  - Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary, 4400
    - Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz
India
- Gujarat
  - Surat, Gujarat, India, 395002
    - Nirmal Hospital Pvt Ltd.
- Haryana
  - Gurugram, Haryana, India, 122001
    - Artemis hospital
- Karnataka
  - Bangalore, Karnataka, India, 560069
    - Spandana Oncology Centre (SOC)
- Maharashtra
  - Mumbai, Maharashtra, India, 400012
    - Tata Memorial Hospital
  - Nashik, Maharashtra, India, 422009
    - Apex Wellness Hospital
  - Pune, Maharashtra, India, 411004
    - Deenanath Mangeshkar Hospital & Research Centre
  - Pune, Maharashtra, India, 411004
    - Sahyadri Super Speciality Hospital
  - Thane, Maharashtra, India, 401107
    - Bhakti Vedanta Hospital and Research Institute
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110085
    - Rajiv Gandhi Cancer Institute And Research Centre
- Telangana
  - Hyderabad, Telangana, India, 500034
    - Basavatarakam Indo American Cancer Hospital & Research Institute
- West Bengal
  - Kolkata, West Bengal, India, 700054
    - Apollo Multispeciality Hospitals Limited
Ireland
- - Dublin, Ireland, D9
    - Beaumont Hospital, Dublin
  - Dublin, Ireland, D07 A8NN
    - Mater Misericordiae University Hospital
  - Dublin, Ireland, D04 N2E0
    - St. Vincent's University Hospital
  - Dublin, Ireland, D08 E9P6
    - St. James's Hospital
Israel
- Central District
  - Petah Tikva, Central District, Israel, 4941492
    - Rabin Medical Center
  - Ramat Gan, Central District, Israel, 5265601
    - Sheba Medical Center
- Jerusalem
  - Jerusalem, Jerusalem, Israel, 9112001
    - Hadassah Medical Center
- Northern District
  - Haifa, Northern District, Israel, 3109601
    - Rambam Health Care Campus
- TELL ABĪB
  - Tel Aviv, TELL ABĪB, Israel, 6423906
    - Sourasky Medical Center
Italy
- - Milan, Italy, 20141
    - Istituto Europeo di Oncologia IRCCS
  - Novara, Italy, 28100
    - Azienda Ospedaliero Universitaria Maggiore della Carità
  - Padova, Italy, 35128
    - Istituto Oncologico Veneto IRCCS
  - Roma, Italy, 00168
    - Clinical Trial Center S.p.A
- Emilia-Romagna
  - Bologna, Emilia-Romagna, Italy, 40138
    - IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
  - Meldola(FC), Emilia-Romagna, Italy, 47014
    - IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
- Lazio
  - Rome, Lazio, Italy, 00168
    - Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
- ROMA
  - Rome, ROMA, Italy, 00144
    - Istituto Nazionale Tumori Regina Elena
  - Rome, ROMA, Italy, 00186
    - Ospedale Isola Tiberina - Gemelli Isola
- Tuscany
  - Florence, Tuscany, Italy, 50134
    - Azienda Ospedaliera Universitaria Careggi
Japan
- - Chiba, Japan, 260-8717
    - Chiba Cancer Center
  - Fukuoka, Japan, 811-1395
    - National Hospital Organization Kyushu Cancer Center
  - Hiroshima, Japan, 730-8518
    - Hiroshima City Hiroshima Citizens Hospital
  - Kumamoto, Japan, 862-8655
    - Kumamoto Shinto General Hospital
  - Okayama, Japan, 700-8558
    - Okayama University Hospital
  - Osaka, Japan, 540-0006
    - National Hospital Organization Osaka National Hospital
- Aichi-ken
  - Nagoya, Aichi-ken, Japan, 466-8560
    - Nagoya University Hospital
  - Nagoya, Aichi-ken, Japan, 467-8602
    - Nagoya City University Hospital
  - Nagoya, Aichi-ken, Japan, 464-8681
    - Aichi Cancer Center
- Gunma
  - Otashi, Gunma, Japan, 373-8550
    - Gunma Prefectural Cancer Center
- Hokkaido
  - Sapporo, Hokkaido, Japan, 003-0804
    - National Hospital Organization Hokkaido Cancer Center
- Kanagawa
  - Yokohama, Kanagawa, Japan, 2418515
    - Kanagawa Cancer Center
- Kyoto
  - Sakyo-ku, Kyoto, Japan, 606-8507
    - Kyoto University Hospital
- Miyagi
  - Sendai, Miyagi, Japan, 980-8574
    - Tohoku University Hospital
- Osaka
  - Suita, Osaka, Japan, 565-0871
    - Osaka University Hospital
- Tokyo
  - Bunkyo-ku, Tokyo, Japan, 113-8431
    - Juntendo University Hospital
  - Chuo-ku, Tokyo, Japan, 104-0045
    - National Cancer Center Hospital
  - Koto-ku, Tokyo, Japan, 135-8550
    - The Cancer Institute Hospital of JFCR
  - Shinagawa, Tokyo, Japan, 142-8666
    - Showa University Hospital
  - Shinjuku, Tokyo, Japan, 162-8655
    - National Center for Global Health and Medicine
Netherlands
- North Brabant
  - Breda, North Brabant, Netherlands, 4818 CK
    - Amphia Ziekenhuis, locatie Breda Molengracht
- Utrecht
  - Amersfoort, Utrecht, Netherlands, 3813 TZ
    - Meander Medisch Centrum
Poland
- - Koszalin, Poland, 75-581
    - Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
- Lesser Poland Voivodeship
  - Krakow, Lesser Poland Voivodeship, Poland, 30-727
    - Pratia McM Krakow
  - Krakow, Lesser Poland Voivodeship, Poland, 30-348
    - Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.
- Masovian Voivodeship
  - Warsaw, Masovian Voivodeship, Poland, 03-730
    - WSD Medi
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Poland, 15-027
    - Białostockie Centrum Onkologii im. M. Skłodowskiej-Curie w Białymstoku
- Pomeranian Voivodeship
  - Gdynia, Pomeranian Voivodeship, Poland, 81-519
    - Szpitale Pomorskie Sp. z o. o.
- West Pomeranian Voivodeship
  - Koszalin, West Pomeranian Voivodeship, Poland, 75-581
    - Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie
- Łódź Voivodeship
  - Lodz, Łódź Voivodeship, Poland, 90-302
    - Instytut MSF Sp zoo
Slovakia
- Bratislava Region
  - Bratislava, Bratislava Region, Slovakia, 812 50
    - Onkologicky Ustav sv. Alzbety
  - Bratislava, Bratislava Region, Slovakia, 833 10
    - Narodny onkologicky ustav
- Košice Region
  - Michalovce, Košice Region, Slovakia, 071 01
    - Nemocnica s poliklinikou Stefana Kukuru Michalovce a.s.
- Nitra Region
  - Komárno, Nitra Region, Slovakia, 945 05
    - Nemocnica AGEL Komarno
- Trnava Region
  - Trnava, Trnava Region, Slovakia, 917 75
    - Fakultna nemocnica Trnava
South Korea
- Gyeonggi-do
  - Seongnam-si, Gyeonggi-do, South Korea, 13496
    - CHA Bundang Medical Center, CHA University
- Incheon-gwangyeoksi [incheon]
  - Incheon, Incheon-gwangyeoksi [incheon], South Korea, 21565
    - Gachon University Gil Medical Center
- Kyǒnggi-do
  - Goyang-si, Kyǒnggi-do, South Korea, 10408
    - National Cancer Center
  - Seongnam, Kyǒnggi-do, South Korea, 13620
    - Seoul National University Bundang Hospital
- Seoul-teukbyeolsi [seoul]
  - Gangnam-gu, Seoul-teukbyeolsi [seoul], South Korea, 06273
    - Gangnam Severance Hospital, Yonsei University Health System
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03080
    - Seoul National University Hospital
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03181
    - Kangbuk Samsung Hospital
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 05505
    - Asan Medical Center
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06351
    - Samsung Medical Center
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 08308
    - Korea University Guro Hospital
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06591
    - The Catholic Univ. of Korea Seoul St. Mary's Hospital
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, Seoul-teukbyeolsi [seoul], South Korea, 07985
    - Ewha Womans University Mokdong Hospital
Spain
- - Granada, Spain, 18016
    - Hospital Universitario San Cecilio
  - Madrid, Spain, 28040
    - Hospital Clinico San Carlos
  - Madrid, Spain, 28007
    - Hospital General Universitario Gregorio Marañon
  - Madrid, Spain, 28050
    - Hospital Universitario HM Sanchinarro
  - Madrid, Spain, 28007
    - Hospital Beata María Ana
  - Seville, Spain, 41013
    - Hospital Universitario Virgen del Rocío
- A Coruña [LA Coruña]
  - A Coruña, A Coruña [LA Coruña], Spain, 15006
    - CHUAC-Complejo Hospitalario Universitario A Coruña
- Alicante
  - Elche, Alicante, Spain, 03203
    - Hospital General Universitario de Elche
- Andalusia
  - Seville, Andalusia, Spain, 41009
    - Hospital Universitario Virgen Macarena
- Barcelona
  - Eixample, Barcelona, Spain, 08036
    - Fundació de Recerca Clínic Barcelona
- Barcelona [barcelona]
  - Barcelona, Barcelona [barcelona], Spain, 08035
    - Hospital Universitari Vall d'Hebron
  - L'Hospitalet de Llobregat, Barcelona [barcelona], Spain, 08908
    - Institut Català d'Oncologia - L'Hospitalet
- Basque Country
  - Bilbao, Basque Country, Spain, 48013
    - Osi Bilbao-Basurto
- Catalunya [cataluña]
  - Barcelona, Catalunya [cataluña], Spain, 08036
    - Hospital Clinic de Barcelona
- Cádiz
  - Jerez de la Frontera, Cádiz, Spain, 11407
    - Hospital Jerez de la Frontera
- Madrid, Comunidad de
  - Madrid, Madrid, Comunidad de, Spain, 28041
    - Hospital Universitario 12 de Octubre
- Murcia, Región de
  - El Palmar, Murcia, Región de, Spain, 30120
    - Hospital Clinico Universitario Virgen de La Arrixaca
- Málaga
  - Málaga, Málaga, Spain, 29010
    - Hospital Universitario Virgen de la Victoria
- Valenciana, Comunitat
  - Valencia, Valenciana, Comunitat, Spain, 46009
    - Fundación Instituto Valenciano de Oncología
- València
  - Valencia, València, Spain, 46015
    - Hospital Arnau de Vilanova
Sweden
- - Jönköping, Sweden, 553 05
    - Länssjukhuset Ryhov
- Gävleborgs LÄN [se-21]
  - Gävle, Gävleborgs LÄN [se-21], Sweden, 81087
    - Gävle sjukhus
- Stockholms LÄN [se-01]
  - Stockholm, Stockholms LÄN [se-01], Sweden, 11883
    - Södersjukhuset
- Uppsala LÄN [se-03]
  - Uppsala, Uppsala LÄN [se-03], Sweden, 751 85
    - Akademiska Sjukhuset
- Västmanlands LÄN [se-19]
  - Västerås, Västmanlands LÄN [se-19], Sweden, 721 89
    - Västmanlands sjukhus Västerås
Switzerland
- - Chur, Switzerland, 7000
    - Kantonsspital Graubünden
  - Münsterlingen, Switzerland, 8596
    - Kantonsspital Münsterlingen - Spital Thurgau AG
  - Winterthur, Switzerland, 8401
    - Kantonsspital Winterthur
- Canton of Basel-City
  - Basel, Canton of Basel-City, Switzerland, 4056
    - University Hospital Basel
- Canton of Bern
  - Bern, Canton of Bern, Switzerland, 3010
    - Inselspital Bern
- Thurgau
  - Frauenfeld, Thurgau, Switzerland, 8500
    - Kantonsspital Frauenfeld - Spital Thurgau AG
Taiwan
- - Taichung, Taiwan, 407
    - Taichung Veterans General Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 10449
    - Mackay Memorial Hospital
  - Taipei, Taiwan, 112
    - Koo Foundation Sun Yat-Sen Cancer Center
  - Taoyuan City, Taiwan, 333
    - Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital
- Hsinchu
  - Zhubei, Hsinchu, Taiwan, 302
    - National Taiwan University Hospital - Hsinchu branch
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01140
    - Adana Medical Park Seyhan Hastanesi
  - Adana, Turkey (Türkiye), 01370
    - Adana City Hospital
  - Ankara, Turkey (Türkiye), 06520
    - Memorial Ankara Hastanesi
  - Ankara, Turkey (Türkiye), 06560
    - Gazi University Medical Faculty
  - Ankara, Turkey (Türkiye), 06010
    - Gulhane Egitim Arastirma Hastanesi
  - Ankara, Turkey (Türkiye), 06200
    - Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi
  - Ankara, Turkey (Türkiye), 06230
    - Hacettepe Universite Hastaneleri
  - Ankara, Turkey (Türkiye), 06560
    - Gazi University Health Research and Application Center Gazi Hospital
  - Diyarbakır, Turkey (Türkiye), 21200
    - Dicle Üniversitesi
  - Sakarya, Turkey (Türkiye), 54290
    - Sakarya Training and Research Hospital
- İ̇stanbul
  - Istanbul, İ̇stanbul, Turkey (Türkiye), 34214
    - Medipol Mega Universite Hastanesi
  - Istanbul, İ̇stanbul, Turkey (Türkiye), 34722
    - TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
- İ̇zmir
  - Izmir, İ̇zmir, Turkey (Türkiye), 35100
    - Ege Universitesi Hastanesi
United Kingdom
- - Guildford, United Kingdom, GU2 7XX
    - The Royal Surrey County Hospital
  - London, United Kingdom, SW3 6JJ
    - Royal Marsden NHS Foundation Trust
  - Manchester, United Kingdom, M20 4BX
    - The Christie NHS Foundation Trust
- England
  - Harlow, England, United Kingdom, CM20 1QX
    - The Princess Alexandra Hospital NHS Trust
  - Truro, England, United Kingdom, TR1 3LJ
    - The Royal Cornwall Hospital
- KENT
  - Maidstone, KENT, United Kingdom, ME16 9QQ
    - Maidstone Hospital
- Somerset
  - Taunton, Somerset, United Kingdom, TA1 5DA
    - Musgrove Park Hospital
- Surrey
  - Sutton, Surrey, United Kingdom, SM2 5PT
    - The Royal Marsden NHS Foundation Trust
- Warwickshire
  - Coventry, Warwickshire, United Kingdom, CV2 2DX
    - University Hospital Coventry & Warwickshire
United States
- Alabama
  - Birmingham, Alabama, United States, 35249
    - The University of Alabama at Birmingham
  - Birmingham, Alabama, United States, 35233
    - The Kirklin Clinic of UAB Hospital
  - Birmingham, Alabama, United States, 35249
    - University of Alabama At Birmingham Hospital
- Arizona
  - Chandler, Arizona, United States, 85224
    - Ironwood Cancer & Research Centers
  - Gilbert, Arizona, United States, 85297
    - Ironwood Cancer & Research Centers
  - Glendale, Arizona, United States, 85306
    - Ironwood Cancer & Research Centers
  - Goodyear, Arizona, United States, 85395
    - Ironwood Cancer & Research Centers
  - Mesa, Arizona, United States, 85202
    - Ironwood Cancer & Research Centers
  - Mesa, Arizona, United States, 85206
    - Ironwood Cancer & Research Centers
  - Phoenix, Arizona, United States, 85028
    - Ironwood Cancer & Research Centers
  - Scottsdale, Arizona, United States, 85260
    - Ironwood Cancer & Research Centers
- Arkansas
  - Bryant, Arkansas, United States, 72022
    - CARTI Cancer Center Saline County
  - Conway, Arkansas, United States, 72034
    - CARTI Cancer Center Conway
  - Fayetteville, Arkansas, United States, 72703
    - Highlands Oncology
  - Little Rock, Arkansas, United States, 72205
    - CARTI Cancer Center
  - North Little Rock, Arkansas, United States, 72117
    - CARTI Cancer Center North Little Rock Urology
  - North Little Rock, Arkansas, United States, 72117
    - CARTI Cancer Center North Little Rock
  - Pine Bluff, Arkansas, United States, 71603
    - CARTI Cancer Center Pine Bluff
  - Rogers, Arkansas, United States, 72758
    - Highlands Oncology
  - Springdale, Arkansas, United States, 72762
    - Highlands Oncology Group
- California
  - Anaheim, California, United States, 92805
    - Providence Medical Foundation
  - Auburn, California, United States, 95602
    - Sutter Auburn Faith Hospital
  - Berkeley, California, United States, 94704
    - Sutter Health Alta Bates
  - Beverly Hills, California, United States, 90211
    - Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)
  - Beverly Hills, California, United States, 90211
    - Cedars-Sinai Cancer Beverly Hills
  - Cameron Park, California, United States, 95682
    - Marshall Cancer Center
  - Chico, California, United States, 95926
    - Enloe Medical Center
  - Chico, California, United States, 95926
    - Enloe Regional Cancer Center
  - Duarte, California, United States, 91010
    - City of Hope Investigational Drug Service (IDS)
  - Duarte, California, United States, 91010
    - City of Hope(City of Hope National Medical Center,City of Hope Medical Center)
  - Fremont, California, United States, 94538
    - UCSF Washington Hospital Cancer Center/ Washington Hospital Healthcare System
  - Fresno, California, United States, 93710
    - Premier Cancer Care and Infusion Center - Fresno - North Thesta Street
  - Fullerton, California, United States, 92835
    - Providence Medical Foundation
  - Fullerton, California, United States, 92835
    - Providence St. Jude Medical Center
  - Huntington Beach, California, United States, 92648
    - City of Hope - Seacliff
  - Irvine, California, United States, 92618
    - City of Hope at Irvine Lennar
  - Irvine, California, United States, 92618
    - Hoag Hospital Irvine
  - Irvine, California, United States, 92618
    - Hoag Health Center Irvine
  - Irvine, California, United States, 92618
    - City of Hope Investigational Drug Service (IDS)
  - Lancaster, California, United States, 93534
    - City of Hope-Antelope Valley
  - Long Beach, California, United States, 90813
    - City of Hope at Long Beach Elm
  - Los Alamitos, California, United States, 90720
    - Cancer and Blood Research Center, LLC
  - Los Alamitos, California, United States, 90720
    - Cancer and Blood Specialty Clinic / Cancer and Blood Research Center, LLC
  - Los Angeles, California, United States, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, United States, 90033
    - USC/Norris Comprehensive Cancer Center
  - Los Angeles, California, United States, 90033
    - Keck Hospital of USC
  - Los Angeles, California, United States, 90095
    - UCLA Department of Medicine - Hematology/Oncology
  - Los Angeles, California, United States, 90033
    - Norris Healthcare Center 3 (HC3)
  - Los Angeles, California, United States, 90033
    - Los Angeles General Medical Center
  - Los Angeles, California, United States, 90048
    - Cedars-Sinai Cancer at Cedars-Sinai Medical Center (drug treatment and dispensing location)
  - Los Angeles, California, United States, 90064
    - Ellison Medical Institute
  - Newport Beach, California, United States, 92663
    - Hoag Memorial Hospital Presbyterian
  - Newport Beach, California, United States, 92663
    - USC Norris Oncology/Hematology - Newport Beach
  - Newport Beach, California, United States, 92663
    - Keck Medicine of USC Norris Oncology/Hematology - Newport Beach Treatment Center
  - Palo Alto, California, United States, 94304
    - Stanford Cancer Center
  - Palo Alto, California, United States, 94304
    - Stanford Women's Cancer Center
  - Palo Alto, California, United States, 94304
    - Clinical and Translational Research Unit (CTRU)
  - Palo Alto, California, United States, 94301
    - Sutter Health Palo Alto
  - Pasadena, California, United States, 91105
    - Keck Medical Center of USC Pasadena
  - Placerville, California, United States, 95667
    - Marshall Hospital
  - Porter Ranch, California, United States, 91326
    - UCLA Hematology/Oncology - Porter Ranch
  - Roseville, California, United States, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, United States, 95817
    - University of California Davis Medical Center
  - Sacramento, California, United States, 95817
    - University of California Davis (UC Davis) Comprehensive Cancer Center
  - Sacramento, California, United States, 95816
    - Sutter Health - Sutter Institute for Medical Research
  - San Francisco, California, United States, 94158
    - University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center
  - San Luis Obispo, California, United States, 93401
    - UCLA Hematology/Oncology - San Luis Obispo
  - Santa Monica, California, United States, 90404
    - UCLA Hematology/Oncology - Santa Monica
  - Santa Monica, California, United States, 90404
    - UCLA Hematology/Oncology - Parkside
  - Santa Monica, California, United States, 90404
    - Providence Saint John's Health Center
  - Santa Monica, California, United States, 90403
    - Tower Saint John's Imaging
  - South Pasadena, California, United States, 91030
    - City of Hope-South Pasadena
  - Stanford, California, United States, 94305
    - Stanford Health Care, Investigational Drug Service
  - Sunnyvale, California, United States, 94086
    - Sutter Health Sunnyvale
  - Tarzana, California, United States, 91356
    - Cedars-Sinai Cancer Tarzana
  - Torrance, California, United States, 90505
    - Cancer and Blood Specialty Clinic
  - Torrance, California, United States, 90505
    - Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer
  - Truckee, California, United States, 96161
    - Tahoe Forest Cancer Center
  - Upland, California, United States, 91786
    - City of Hope - Upland
  - West Hills, California, United States, 91307
    - Wellness Oncology Hematology
  - West Hollywood, California, United States, 90048
    - Breast Health Services Building
  - Westlake Village, California, United States, 91361
    - UCLA Hematology/Oncology - Westlake
- Colorado
  - Denver, Colorado, United States, 80204
    - Denver Health and Hospital Authority
  - Golden, Colorado, United States, 80401
    - Lutheran Hospital - Cancer Centers of Colorado
  - Golden, Colorado, United States, 80401
    - Intermountain Health Lutheran Hospital
  - Grand Junction, Colorado, United States, 81501
    - Cancer Centers of Colorado St. Mary's Regional Hospital
  - Grand Junction, Colorado, United States, 81501
    - Intermountain Health Saint Mary's Regional Hospital
  - Grand Junction, Colorado, United States, 81505
    - Intermountain Health
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20010
    - MedStar Washington Hospital Center
- Florida
  - Altamonte Springs, Florida, United States, 32701
    - AdventHealth Altamonte Infusion Center
  - Altamonte Springs, Florida, United States, 32701
    - AdventHealth Medical Group Altamonte
  - Altamonte Springs, Florida, United States, 32701
    - AdventHealth Altamonte Springs
  - Boca Raton, Florida, United States, 33486
    - Boca Raton Regional Hospital
  - Jacksonville, Florida, United States, 32207
    - Baptist Md Anderson Cancer Center
  - Orlando, Florida, United States, 32803
    - AdventHealth Orlando
  - Orlando, Florida, United States, 32804
    - AdventHealth Orlando Infusion Center
  - Orlando, Florida, United States, 32804
    - AdventHealth Medical Group Orlando
- Georgia
  - Savannah, Georgia, United States, 31405
    - Summit Cancer Care, PC
- Idaho
  - Boise, Idaho, United States, 83712
    - St. Luke's Regional Medical Center
  - Boise, Idaho, United States, 83712
    - St. Luke's Cancer Institute: Boise
  - Fruitland, Idaho, United States, 83619
    - St. Luke's Cancer Institute-Fruitland
  - Meridian, Idaho, United States, 83642
    - St. Luke's Cancer Institute-Meridian
  - Meridian, Idaho, United States, 83642
    - St. Lukes Meridian Medical Center
  - Nampa, Idaho, United States, 83687
    - St. Luke's Cancer Institute-Nampa
- Illinois
  - Calumet City, Illinois, United States, 60409
    - Ingalls Family Care Center
  - Chicago, Illinois, United States, 60612
    - University of Illinois at Chicago
  - Chicago, Illinois, United States, 60637
    - University of Chicago Medical Center
  - Chicago, Illinois, United States, 60637
    - University of Chicago Medical Center, CCD
  - Chicago, Illinois, United States, 60612
    - University of Illinois Hospital and Health Sciences System
  - Chicago, Illinois, United States, 60611
    - UChicago Medicine - River East
  - Elmhurst, Illinois, United States, 60126
    - Endeavor Health Cancer Institute at Swedish Hospital, Nancy W. Knowles Cancer Center
  - Evanston, Illinois, United States, 60201
    - Endeavor Health
  - Evanston, Illinois, United States, 60202
    - Prime Saint Francis-Infusion Services Evanston
  - Flossmoor, Illinois, United States, 60422
    - UChicago Medicine at Ingalls - Flossmoor
  - Harvey, Illinois, United States, 60426
    - UChicago Medicine Ingalls Memorial
  - Hinsdale, Illinois, United States, 60521
    - Hope and Healing Cancer Services
  - Naperville, Illinois, United States, 60540
    - Endeavor Health Cancer Institute at Swedish Hospital
  - New Lenox, Illinois, United States, 60451
    - University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
  - New Lenox, Illinois, United States, 60451
    - Hope and Healing Cancer Services
  - Orland Park, Illinois, United States, 60462
    - The University of Chicago Medicine Center for Advanced Care Orland Park.
  - Shiloh, Illinois, United States, 62269
    - Siteman Cancer Center - Shiloh
  - Shiloh, Illinois, United States, 62269
    - Memorial Hospital
  - Skokie, Illinois, United States, 60077
    - Orchard Healthcare Research Inc.
  - Skokie, Illinois, United States, 60077
    - Prime Saint Francis-Infusion Services Skokie
  - Tinley Park, Illinois, United States, 60477
    - UChicago Medicine at Ingalls - Tinley Park
- Indiana
  - Crown Point, Indiana, United States, 46307
    - UChicago Medicine - Northwest Indiana
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Velocity Clinical Research
  - Baltimore, Maryland, United States, 21202
    - Mercy Medical Center - Baltimore
  - Columbia, Maryland, United States, 21044
    - MedStar Health Research Institute, Inc
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, United States, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, United States, 02115
    - Brigham and Women's Hospital
  - Newton, Massachusetts, United States, 02459
    - Dana-Farber Cancer Institute - Chestnut Hill
- Minnesota
  - Coon Rapids, Minnesota, United States, 55433
    - Allina Health Cancer Institute - Mercy Hospital
  - Minneapolis, Minnesota, United States, 55407
    - Allina Health Cancer Institute - Abbott Northwestern Hospital
  - Plymouth, Minnesota, United States, 55441
    - Allina Health Cancer Institute - WestHealth
  - Saint Paul, Minnesota, United States, 55102
    - Allina Health Cancer Institute - United Hospital
  - Shakopee, Minnesota, United States, 55379
    - St. Francis Cancer Center
- Missouri
  - City of Saint Peters, Missouri, United States, 63376
    - Siteman Cancer Center - St Peters
  - Creve Coeur, Missouri, United States, 63141
    - Siteman Cancer Center - West County
  - Florissant, Missouri, United States, 63031
    - Siteman Cancer Center - North County
  - Kansas City, Missouri, United States, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, United States, 64111
    - Saint Luke's Cancer Institute
  - St Louis, Missouri, United States, 63110
    - Barnes-Jewish Hospital
  - St Louis, Missouri, United States, 63110
    - Washington University School of Medicine - Siteman Cancer Center
  - St Louis, Missouri, United States, 63129
    - Siteman Cancer Center - South County
  - St Louis, Missouri, United States, 63108
    - Siteman Cancer Center
- Montana
  - Bozeman, Montana, United States, 59715
    - Bozeman Health Deaconess Hospital
- Nevada
  - Reno, Nevada, United States, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, United States, 89521
    - Renown South Meadows Medical Center
  - Reno, Nevada, United States, 89502
    - Renown Health Medical Oncology
  - Reno, Nevada, United States, 89502
    - Renown Office of Clinical Research
  - Reno, Nevada, United States, 89521
    - Renown Health Conrad Breast Center
- New Jersey
  - Livingston, New Jersey, United States, 07039
    - Cooperman Barnabas Medical Center
  - New Brunswick, New Jersey, United States, 08901
    - Rutgers Cancer Institute
  - New Brunswick, New Jersey, United States, 08901
    - Jack & Sheryl Morris Cancer Center
  - Somerville, New Jersey, United States, 08876
    - Robert Wood Johnson University Hospital Somerset
- New York
  - Brooklyn, New York, United States, 11220
    - NYU Langone Health - Brooklyn
  - Brooklyn, New York, United States, 11220
    - Perlmutter Cancer Center - Sunset Park
  - Mineola, New York, United States, 11501
    - Perlmutter Cancer Center at NYU Langone Hospital - Long Island
  - Mineola, New York, United States, 11501
    - Perlmutter Cancer Center at NYU Winthrop Hospital Infusion Center
  - New York, New York, United States, 10016
    - Laura and Isaac Perlmutter Cancer Center
  - New York, New York, United States, 10016
    - NYU Langone Medical Center - Tisch Hospital
  - Rochester, New York, United States, 14642
    - University of Rochester Medical Center
  - Rochester, New York, United States, 14642
    - University of Rochester Cancer Center Pharmacy
  - Stony Brook, New York, United States, 11794
    - Stony Brook University
- North Carolina
  - Chapel Hill, North Carolina, United States, 27514
    - University of North Carolina Medical Center
  - Hillsborough, North Carolina, United States, 27278
    - University of North Carolina Hospitals at Hillsborough
- Ohio
  - Cincinnati, Ohio, United States, 45237
    - Bon Secours Mercy Health, Inc
  - Columbus, Ohio, United States, 43210
    - Ohio State University Hospital
  - Columbus, Ohio, United States, 43210
    - The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C
  - Columbus, Ohio, United States, 43212
    - Stefanie Spielman Comprehensive Breast Cancer
- Oregon
  - Albany, Oregon, United States, 97321
    - Oncology Associates of Oregon, P.C.
  - Eugene, Oregon, United States, 97401
    - Oncology Associates of Oregon, P.C.
  - Portland, Oregon, United States, 97213
    - Providence Cancer Institute Franz Clinic
  - Portland, Oregon, United States, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, United States, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, United States, 97225
    - Providence Oncology and Hematology Care Clinic - Westside
  - Portland, Oregon, United States, 97213
    - Providence Portland Medical Center Investigational Drug Services
  - Portland, Oregon, United States, 97225
    - Providence Investigational Drug Service - Westside
  - Springfield, Oregon, United States, 97477
    - Oncology Associates of Oregon, P.C.
- Texas
  - Arlington, Texas, United States, 76012
    - Texas Oncology - DFW
  - Arlington, Texas, United States, 76014
    - Texas Oncology - DFW
  - Bedford, Texas, United States, 76022
    - Texas Oncology - DFW
  - Dallas, Texas, United States, 75246
    - Texas Oncology - DFW
  - Dallas, Texas, United States, 75231
    - Texas Oncology - DFW
  - Dallas, Texas, United States, 75203
    - Texas Oncology - DFW
  - Dallas, Texas, United States, 75230
    - Texas Oncology - DFW
  - Dallas, Texas, United States, 75237
    - Texas Oncology - DFW
  - Fort Worth, Texas, United States, 76104
    - Texas Oncology - DFW
  - Grapevine, Texas, United States, 76051
    - Texas Oncology - DFW
  - Irving, Texas, United States, 75063
    - US Oncology Investigational Products Center
  - Irving, Texas, United States, 75063
    - US Oncology Investigational Product Center (IPC)
  - Irving, Texas, United States, 75063
    - US Oncology lnvestigational Products Center (IPC)
  - Plano, Texas, United States, 75075
    - Texas Oncology - DFW
  - Plano, Texas, United States, 75093
    - Texas Oncology - DFW
  - Round Rock, Texas, United States, 78665
    - Baylor Scott & White Medical Center - Round Rock
  - Tyler, Texas, United States, 75701
    - The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center
  - Tyler, Texas, United States, 75708
    - The University of Texas Health Science Center at Tyler on behalf of UT Health East Texas HOPE Cancer
- Utah
  - Bountiful, Utah, United States, 84010
    - Utah Cancer Specialists
  - Layton, Utah, United States, 84041
    - Utah Cancer Specialists
  - Murray, Utah, United States, 84107
    - Utah Cancer Specialists
  - Ogden, Utah, United States, 84405
    - Utah Cancer Specialists
  - Orem, Utah, United States, 84057
    - Utah Cancer Specialists
  - Pleasant Grove, Utah, United States, 84062
    - Utah Cancer Specialists
  - Provo, Utah, United States, 84604
    - Utah Cancer Specialists
  - Salt Lake City, Utah, United States, 84106
    - Utah Cancer Specialists
  - Salt Lake City, Utah, United States, 84102
    - Utah Cancer Specialists
  - West Jordan, Utah, United States, 84088
    - Utah Cancer Specialists
  - West Valley City, Utah, United States, 84119
    - Utah Cancer Specialists
- Virginia
  - Fairfax, Virginia, United States, 22031
    - Virginia Cancer Specialists, PC
  - Manassas, Virginia, United States, 20110
    - Virginia Cancer Specialists, PC
  - Mechanicsville, Virginia, United States, 23116
    - Bon Secours Cancer Institute at Memorial Regional
  - Midlothian, Virginia, United States, 23114
    - Bon Secours St. Francis Medical Center
  - Reston, Virginia, United States, 20190
    - Virginia Cancer Specialists, PC
  - Richmond, Virginia, United States, 23226
    - Bon Secours Cancer Institute at St. Mary's
- Wisconsin
  - Madison, Wisconsin, United States, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Madison, Wisconsin, United States, 53718
    - University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Histological confirmation of breast cancer with evidence of locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent.
Documented estrogen receptor (ER) and/or progesterone receptor (PR)-positive tumor
Documented HER2-negative tumor
Previously untreated with any systemic anticancer therapy for their locally advanced or metastatic disease.
Measurable disease or non-measurable bone only disease as defined by RECIST version 1.1

Exclusion Criteria:

In visceral crisis at risk of immediately life-threatening complications in the short term.
Current or past history of central nervous system metastases.
Have received prior (neo)adjuvant endocrine therapy (ET) and had recurrence during or within 12 months after the last dose of ET.
Have received prior (neo)adjuvant CDK4/6i and had recurrence during or within 12 months after the last dose of CDK4/6i.
Inadequate renal function, hepatic dysfunction, or hematologic abnormalities.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Arm A PF-07220060 tablet taken by mouth plus Letrozole tablet taken by mouth	Drug: PF-07220060 CDK4 inhibitor Drug: letrozole endocrine therapy
Active Comparator: Arm B Investigator's Choice of CDK4/6 inhibitor (tablet/capsule) taken by mouth with letrozole tablet taken by mouth	Drug: letrozole endocrine therapy Drug: abemaciclib CDK4/6 inhibitor Drug: palbociclib CDK4/6 inhibitor Drug: ribociclib CDK4/6 inhibitor

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Progression Free Survival (PFS) by BICR Time Frame: From the date of randomization until disease progression or death due to any cause (up to approximately 4 years)	Time from the date of randomization to the date of the first documentation of objective progressive disease as determined by blinded independent central review (BICR) per RECIST v1.1, or death due to any cause, whichever occurs first	From the date of randomization until disease progression or death due to any cause (up to approximately 4 years)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall Survival (OS) Time Frame: From the date of randomization until death due to any cause (up to approximately 13 years).	Time from the date of randomization to the date of death due to any cause	From the date of randomization until death due to any cause (up to approximately 13 years).
Progression Free Survival (PFS) by Investigator Time Frame: From the date of randomization until disease progression or death due to any cause (up to approximately 4 years)	Time from the date of randomization to the date of the first documentation of objective progressive disease as determined by investigator per RECIST v1.1, or death due to any cause, whichever occurs first	From the date of randomization until disease progression or death due to any cause (up to approximately 4 years)
OR by BICR and by investigator Time Frame: From randomization to progression or death whichever occurs first (up to approximately 4 years)	Time from randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death whichever occurs first	From randomization to progression or death whichever occurs first (up to approximately 4 years)
Duration of Response (DoR) by BICR and by investigator Time Frame: From the date of CR or PR until objective progressive disease, or death (up to approximately 4 years)	Time from the date of CR or PR to the first documentation of objective progressive disease, or death due to any cause, whichever occurs first	From the date of CR or PR until objective progressive disease, or death (up to approximately 4 years)
Incidence of treatment emergent treatment related adverse events (AE) Time Frame: Duration of the study approximately up to 13 years.	Incidence and severity of AEs graded according to the NCI CTCAE v5.0	Duration of the study approximately up to 13 years.
Incidence of treatment emergent treatment related serious adverse events Time Frame: Duration of the study approximately up to 13 years.	Incidence and severity of AEs graded according to NCI CTCAE v5.0	Duration of the study approximately up to 13 years.
Estimated mean change from baseline in EORTC QLQ C30 Time Frame: Baseline to end of treatment (up to approximately 4 years)		Baseline to end of treatment (up to approximately 4 years)
Estimated mean change from baseline in BPI-SF Time Frame: Baseline to end of treatment (up to approximately 4 years)		Baseline to end of treatment (up to approximately 4 years)
Estimated mean change from baseline in EQ-5D-5L Time Frame: Baseline to end of treatment (up to approximately 4 years)		Baseline to end of treatment (up to approximately 4 years)
Estimated mean change from baseline in EORTC Breast Cancer Module (BR42) Time Frame: Baseline to end of treatment (up to approximately 4 years)		Baseline to end of treatment (up to approximately 4 years)
Mean change from baseline of ctDNA Time Frame: Baseline to end of treatment (up to approximately 4 years)		Baseline to end of treatment (up to approximately 4 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pfizer

Investigators

Study Director: Pfizer CT.gov Call Center, Pfizer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

To obtain contact information for a study center near you, click here.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 6, 2025

Primary Completion (Estimated)

January 2, 2029

Study Completion (Estimated)

December 29, 2037

Study Registration Dates

First Submitted

December 11, 2024

First Submitted That Met QC Criteria

January 3, 2025

First Posted (Actual)

January 7, 2025

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 18, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

C4391024
2024-512925-95-00 (Registry Identifier: CTIS (EU))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Breast Cancer

Clinical Trials on PF-07220060

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