Pennington Generation Cohort

The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes.

Study Overview

• Status: Recruiting
• Conditions: Obesity Prevention

Detailed Description

Pennington Biomedical's Greaux Healthy initiative partners with communities to grow healthier generations by expanding the access and reach of Pennington Biomedical's evidence-based practices for the prevention and treatment of childhood obesity. As part of Greaux Healthy, the Pennington Generation Cohort will help evaluate the impact of the program. A sample of up to 1,500 children and adolescents and their families will be recruited from throughout Louisiana. An initial physical exam will establish a baseline for each family with respect to lifestyle behaviors, genetics, and body size/composition. This longitudinal cohort will also assess the association between participation in several childhood obesity prevention and treatment programs and subsequent obesity and related health outcomes. Members of the longitudinal cohort will be followed in the future through clinical visits, questionnaires, and through optional linkages to electronic medical records and administrative databases such as the National Death Index, Social Security Death Master File, and health registry data.

• Study Type: Observational
• Enrollment (Estimated): 3000

Contacts and Locations

• Study Contact: Name: Peter T Katzmarzyk, PhD; Phone Number: 225-763-2536; Email: Peter.katzmarzyk@pbrc.edu
• Study Contact Backup: Name: Kara Denstel, PhD; Phone Number: 763-2614; Email: kara.denstel@pbrc.edu

Study Locations

• United States
  • Louisiana
    • Baton Rouge, Louisiana, United States, 70808
      • Recruiting
      • Pennington Biomedical Research Center
      • Contact: Peter T Katzmarzyk, PhD; Phone Number: 225-763-2536; Email: Peter.katzmarzyk@pbrc.edu
      • Contact: Peter T Katzmarzyk, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Adults of child-bearing age who are planning to become pregnant, expectant parents, as well as children, adolescents, and young adults and their nuclear family members will be recruited.

Description

Inclusion Criteria:

• Children, adolescents, and young adults (birth through age 24 years) and their nuclear family members* and adults age 25+ who are expectant parents or are trying to conceive
• Self-reported resident of Louisiana
• Ability to understand instructions and complete all study procedures
• Able to provide informed consent (adults aged over 18 years)
• Able to provide assent (children 9 to 17 years)
• Able to communicate (oral and written) in English

Exclusion Criteria:

• Discretion of the Medical Monitor or Principal Investigator

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Obesity	The development of obesity, defined using BMI z-scores during childhood, and BMI during adulthood.	From enrollment up to 20 years of follow-up.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Weight change	Change in body weight.	From enrollment up to 20 years of follow-up.
Mortality	Data from the Pennington Generation Prospective Cohort will be prospectively linked to the National Death Index for the ascertainment of mortality.	From enrollment up to 20 years of follow-up..
Cancer incidence	Data from the Pennington Generation Prospective Cohort will be prospectively linked to the Louisiana Tumor Registry for the ascertainment of incident cancer.	From enrollment up to 20 years of follow-up..

Collaborators and Investigators

• Sponsor: Pennington Biomedical Research Center
• Investigators: Principal Investigator: Peter T Katzmarzyk, PhD, Pennington Biomedical Research Center

Study record dates

Study Major Dates

• Study Start (Actual): February 24, 2025
• Primary Completion (Estimated): February 24, 2045
• Study Completion (Estimated): February 24, 2045

Study Registration Dates

• First Submitted: February 19, 2025
• First Submitted That Met QC Criteria: February 24, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: March 13, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: physical activity; obesity; nutrition; diet; families
• Additional Relevant MeSH Terms: Nutrition Disorders; Overnutrition; Body Weight; Overweight; Obesity
• Other Study ID Numbers: 2024-036

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: A de-identified individual-level dataset will be made available to researchers making a reasonable request to the principal investigator.
• IPD Sharing Time Frame: Data will be made available 1 year after publication of the primary outcomes manuscript.
• IPD Sharing Access Criteria: Upon reasonable request to the principal investigator and in alignment with the goals of the IRB-approved protocol.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No