A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

June 1, 2026 updated by: Mirati Therapeutics Inc.

A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

630

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: First line of the email MUST contain NCT # and Site #.

Study Contact Backup

  • Name: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
  • Phone Number: 855-907-3286
  • Email: Clinical.Trials@bms.com

Study Locations

  • Argentina
    • Buenos Aires
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
        • Recruiting
        • Instituto Alexander Fleming
        • Contact:
          • Claudio Martin, Site 0575
          • Phone Number: 5491166936669
      • Ciudad de Buenos Aires, Buenos Aires, Argentina, C1012AAR
        • Recruiting
        • IDIM - Instituto de Investigaciones Metabólicas
        • Contact:
          • Mara Rapaccioli, Site 0570
          • Phone Number: 1124870006
      • Pilar, Buenos Aires, Argentina, 1629
        • Recruiting
        • Hospital Universitario Austral
        • Contact:
          • Nicolas Minatta, Site 0584
          • Phone Number: 5491138018573
    • Buenos Aires F.D.
      • ABB, Buenos Aires F.D., Argentina, C1199ABB
        • Recruiting
        • Hospital Italiano de Buenos Aires
        • Contact:
          • Lorena Lupinacci, Site 0576
          • Phone Number: 5411495902008159
      • Buenos Aires, Buenos Aires F.D., Argentina, C1417DTB
        • Withdrawn
        • Local Institution - 0571
      • CABA, Buenos Aires F.D., Argentina, C1430EGF
        • Recruiting
        • Clinica Adventista Belgrano
        • Contact:
          • Aldo Perfetti, Site 0573
          • Phone Number: 5491132682903
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, 2000
        • Recruiting
        • Sanatorio Plaza
        • Contact:
          • Miriam Raimondo, Site 0595
          • Phone Number: +549341644-8821
  • Australia
    • Australian Capital Territory
      • Canberra, Australian Capital Territory, Australia, 2605
        • Recruiting
        • Canberra Hospital
        • Contact:
          • Geoffrey Peters, Site 0126
          • Phone Number: 610251242220
    • New South Wales
      • North Tamworth, New South Wales, Australia, 2340
        • Recruiting
        • Tamworth Hospital
        • Contact:
          • Sunil Rai, Site 0212
          • Phone Number: 0267677760
      • Orange, New South Wales, Australia, 2800
        • Recruiting
        • Orange Hospital
        • Contact:
          • Robert Zielinski, Site 0128
          • Phone Number: 61263693380
    • Queensland
      • Brisbane, Queensland, Australia, 4102
        • Recruiting
        • Princess Alexandra Hospital
        • Contact:
          • Kenneth O'Byrne, Site 0127
          • Phone Number: 0731766505
    • South Australia
      • Elizabeth Vale, South Australia, Australia, 5112
        • Recruiting
        • Lyell McEwin Hospital
        • Contact:
          • Dainik Patel, Site 0129
          • Phone Number: 0433217127
    • Victoria
      • Frankston, Victoria, Australia, 3199
        • Recruiting
        • Frankston Hospital
        • Contact:
          • Emma Beardsley, Site 0122
          • Phone Number: 61397847777
      • Melbourne, Victoria, Australia, 3076
        • Recruiting
        • Northern Hospital
        • Contact:
          • Vishal Boolell, Site 0121
          • Phone Number: 0434 479 184
      • Traralgon, Victoria, Australia, 3844
        • Recruiting
        • Latrobe Regional Health
        • Contact:
          • Evangeline Samuel, Site 0160
          • Phone Number: 03 5173 8000
    • Western Australia
      • Joondalup, Western Australia, Australia, 6027
        • Recruiting
        • Joondalup Health Campus
        • Contact:
          • Arman Hasani, Site 0229
          • Phone Number: 61863889681
  • Austria
      • Linz, Austria, 4021
        • Recruiting
        • Kepler Universitätsklinikum
        • Contact:
          • David Lang, Site 0530
          • Phone Number: 4373278066910
      • Vienna, Austria, 1090
        • Recruiting
        • Medizinische Universitat Wien
        • Contact:
          • Thorsten Fuereder, Site 0533
          • Phone Number: 4314040044450
      • Vienna, Austria, 1210
        • Not yet recruiting
        • Local Institution - 0673
        • Contact:
          • Site 0673
    • Styria
      • Graz, Styria, Austria, 8036
        • Recruiting
        • Medizinische Universität Graz
        • Contact:
          • Gudrun Absenger, Site 0539
          • Phone Number: 4331638581318
    • Upper Austria
      • Wels, Upper Austria, Austria, 4600
        • Recruiting
        • Klinikum Wels-Grieskirchen GmbH
        • Contact:
          • Christian Trockenbacher, Site 0532
          • Phone Number: 4372424152382
  • Belgium
      • Liège, Belgium, 4000
        • Recruiting
        • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
        • Contact:
          • Anne Sibille, Site 0109
          • Phone Number: 003243237400
    • Bruxelles-Capitale, Région de
      • Brussels, Bruxelles-Capitale, Région de, Belgium, 1090
        • Recruiting
        • UZ Brussel
        • Contact:
          • Lore Decoster, Site 0114
          • Phone Number: 3224775457
      • Brussels, Bruxelles-Capitale, Région de, Belgium, 1200
        • Recruiting
        • Cliniques Universitaires Saint-Luc
        • Contact:
          • Frank Nana Aboubakar, Site 0113
          • Phone Number: 3227648519
    • Limburg
      • Hasselt, Limburg, Belgium, 3500
        • Recruiting
        • Jessa Ziekenhuis
        • Contact:
          • Kristof Cuppens, Site 0215
          • Phone Number: +32472565987
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, Belgium, 9000
        • Recruiting
        • AZ Maria Middelares
        • Contact:
          • Paul Germonpre, Site 0216
          • Phone Number: 3292468400
    • Vlaams-Brabant
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Recruiting
        • UZ Leuven
        • Contact:
          • christophe Dooms, Site 0107
          • Phone Number: 003216340961
  • Brazil
      • Rio de Janeiro, Brazil, 20230-130
        • Recruiting
        • Instituto Nacional de Cancer - INCa
        • Contact:
          • Luiz Henrique Araujo, Site 0236
          • Phone Number: 552132076585
      • São Paulo, Brazil, 01246-000
        • Recruiting
        • Icesp - Instituto Do Câncer Do Estado de São Paulo
        • Contact:
          • Milena Perez Mak, Site 0258
          • Phone Number: 551138932632
    • Espírito Santo
      • Vitória, Espírito Santo, Brazil, 29055450
        • Recruiting
        • CEDOES
        • Contact:
          • Mauricio Pereira, Site 0242
          • Phone Number: +5521998795727
    • Estado de Bahia
      • Salvador, Estado de Bahia, Brazil, 40170-110
        • Recruiting
        • Nucleo de Oncologia da Bahia
        • Contact:
          • Filipe Visani, Site 0257
          • Phone Number: +5571983140522
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30110-022
        • Recruiting
        • Cetus Oncologia - Unidade Belo Horizonte
        • Contact:
          • Elisa Ramos, Site 0244
          • Phone Number: 5531998619660
    • Rio Grande do Sul
      • Ijuí, Rio Grande do Sul, Brazil, 98700-000
        • Recruiting
        • ONCOSITE - Centro de Pesquisa Clinica em Oncologia
        • Contact:
          • Fabio Franke, Site 0235
          • Phone Number: +5555991592101
      • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
        • Recruiting
        • Hospital São Lucas da PUCRS
        • Contact:
          • Ana Caroline Gelatti, Site 0233
          • Phone Number: (51)3320-3039
      • Santa Cruz do Sul, Rio Grande do Sul, Brazil, 96830-180
        • Recruiting
        • Instituto de Oncologia Saint Gallen
        • Contact:
          • Bianca Correa Tabajara Weiss, Site 0238
          • Phone Number: 5551991898942
    • Rondônia
      • Porto Velho, Rondônia, Brazil, 76834-899
        • Recruiting
        • Hospital de Amor Amazônia
        • Contact:
          • Jéssica Câmara, Site 0243
          • Phone Number: 38999986193
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazil, 89010-340
        • Recruiting
        • Clinica de Oncologia Reichow
        • Contact:
          • Sandro Reichow, Site 0237
          • Phone Number: 5547996670458
      • Itajaí, Santa Catarina, Brazil, 88301-220
        • Recruiting
        • Clinica de Neoplasias Litoral
        • Contact:
          • Giuliano Borges, Site 0245
          • Phone Number: 5547984046243
    • São Paulo
      • Barretos, São Paulo, Brazil, 14784400
        • Recruiting
        • Fundacao Pio Xii - Hospital De Cancer De Barretos
        • Contact:
          • Gustavo Dix Junqueira Pinto, Site 0240
          • Phone Number: 551733216637
      • São Carlos, São Paulo, Brazil, 13561-130
        • Recruiting
        • Advanze Pesquisa
        • Contact:
          • Luiz Agenor Gazzi, Site 0241
          • Phone Number: 551633711320
      • São José do Rio Preto, São Paulo, Brazil, 15090-000
        • Recruiting
        • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
        • Contact:
          • JOÃO SOLER, Site 0239
          • Phone Number: 551732015054
      • São Paulo, São Paulo, Brazil, 01509-010
        • Recruiting
        • A. C. Camargo Cancer Center
        • Contact:
          • Vladmir Cordeiro de Lima, Site 0254
          • Phone Number: +5511976470332
  • Bulgaria
      • Rousse, Bulgaria, 7002
        • Recruiting
        • Complex Oncology Center - Ruse EOOD
        • Contact:
          • Nikolay Nikolaev, Site 0627
          • Phone Number: 0887098616
      • Stara Zagora, Bulgaria, 6000
        • Recruiting
        • Trakia Hospital
        • Contact:
          • Rumyana Ilieva, Site 0635
          • Phone Number: 00359888431354
    • Pazardzhik
      • Panagyurishte, Pazardzhik, Bulgaria, 4500
        • Recruiting
        • MBAL Uni Hospital
        • Contact:
          • Rossitza Krasteva, Site 0629
          • Phone Number: +359888938571
    • Sofia (stolitsa)
      • Sofia, Sofia (stolitsa), Bulgaria, 1632
        • Recruiting
        • Multiprofile Hospital for Active Treatment Serdika EOOD
        • Contact:
          • Krassimir Koynov, Site 0628
          • Phone Number: 359888223107
  • Canada
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Not yet recruiting
        • Local Institution - 0074
        • Contact:
          • Site 0074
    • Quebec
      • Montreal, Quebec, Canada, H3T 1M5
        • Not yet recruiting
        • Local Institution - 0559
        • Contact:
          • Site 0559
  • Chile
    • Santiago Metropolitan
      • Recoleta, Santiago Metropolitan, Chile, 8420391
        • Recruiting
        • Bradfordhill
        • Contact:
          • Carlos Rojas, Site 0574
          • Phone Number: +56998744662
      • Santiago, Santiago Metropolitan, Chile, 7500921
        • Recruiting
        • FALP
        • Contact:
          • Christian Caglevic, Site 0577
          • Phone Number: 56224457254
  • China
    • Anhui
      • Bengbu, Anhui, China, 233017
        • Recruiting
        • The First Afflilated Hospital of Bengbu Medical College
        • Contact:
          • Chengling Zhao, Site 0482
          • Phone Number: +8618105527755
      • Hefei, Anhui, China, 230001
        • Recruiting
        • Anhui Provincial Hospital
        • Contact:
          • Junqiang Zhang, Site 0475
          • Phone Number: 8618955142161
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer Hospital
        • Contact:
          • Jian Fang, Site 0355
          • Phone Number: 861088196479
      • Beijing, Beijing Municipality, China, 100730
        • Recruiting
        • Beijing Peking Union Medical College Hospital
        • Contact:
          • mengzhao wang, Site 0491
          • Phone Number: 13911235467
      • Beijing, Beijing Municipality, China, 101149
        • Recruiting
        • Beijing Chest Hospital,Capital Medical University
        • Contact:
          • Zhe Liu, Site 0397
          • Phone Number: 010-8909303
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400030
        • Recruiting
        • Chongqing University Cancer Hospital
        • Contact:
          • Dan Yang, Site 0490
          • Phone Number: +8613983895620
    • Fujian
      • Fuzhou Fujian, Fujian, China, 350001
        • Recruiting
        • Fujian Medical University Union Hospital
        • Contact:
          • Xiaoyan Lin, Site 0362
          • Phone Number: 8613950482366
      • Xiamen, Fujian, China, 361003
        • Recruiting
        • The First Affiliated Hospital of Xiamen University
        • Contact:
          • Feng Ye, Site 0383
          • Phone Number: 8613860458889
    • Guangdong
      • Guangzhou, Guangdong, China, 510140
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University
        • Contact:
          • Chengzhi Zhou, Site 0625
          • Phone Number: 13560351176
      • Guangzhou, Guangdong, China
        • Recruiting
        • The First Affiliated Hospital, Sun Yat-sen University
        • Contact:
          • Kejing Tang, Site 0469
          • Phone Number: 8613802946566
      • Shantou, Guangdong, China, 515041
        • Recruiting
        • Cancer Hospital of Shantou University Medical College
        • Contact:
          • Wen Lin, Site 0356
          • Phone Number: 13612388011
      • Shenzhen, Guangdong, China, 518020
        • Recruiting
        • ShenZhen People's Hospital
        • Contact:
          • Di Wu, Site 0352
          • Phone Number: 8613662589160
      • Shenzhen, Guangdong, China
        • Recruiting
        • Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
        • Contact:
          • Jianhua Chang, Site 0461
          • Phone Number: 8618017312689
    • Guangxi
      • Nanning, Guangxi, China, 530021
        • Recruiting
        • Guangxi Medical University Affiliated Tumor Hospital
        • Contact:
          • Aiping Zeng, Site 0464
          • Phone Number: 13367816089
    • Hebei
      • Shijiazhuang, Hebei, China, 050035
        • Recruiting
        • Fourth Hospital of Hebei Medical University
        • Contact:
          • Ping Wang, Site 0472
          • Phone Number: 13931130696
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150081
        • Recruiting
        • Harbin medical university cancer hospital
        • Contact:
          • Yan Yu, Site 0465
          • Phone Number: 13904505825
    • Henan
      • Nanyang, Henan, China, 473009
        • Recruiting
        • Nanyang City Center Hospital
        • Contact:
          • Lixin Wan, Site 0626
          • Phone Number: +8613838708656
      • Xinxiang, Henan, China, 453100
        • Recruiting
        • The First Affiliated Hospital of Xinxiang Medical University
        • Contact:
          • Yinghua Ji, Site 0494
          • Phone Number: 8613663030446
    • Hubei
      • Wuhan, Hubei, China, 430030
        • Recruiting
        • Tongji Hospital Tongji Medical,Science & Technology
        • Contact:
          • Qian Chu, Site 0373
          • Phone Number: 8613212760751
    • Hunan
      • Changsha, Hunan, China, 410013
        • Recruiting
        • Hunan Cancer hospital
        • Contact:
          • Lin Wu, Site 0398
          • Phone Number: 8613170419973
    • Jiangsu
      • Nanjing, Jiangsu, China, 210000
        • Recruiting
        • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
        • Contact:
          • Lifeng Wang, Site 0371
          • Phone Number: 13951699955
      • Suzhou, Jiangsu, China, 215006
        • Recruiting
        • The First Affiliated Hospital of Soochow University
        • Contact:
          • Chuanyong Mu, Site 0382
          • Phone Number: 18912615299
      • Yangzhou, Jiangsu, China, 225001
        • Recruiting
        • Northern Jiangsu People's Hospital
        • Contact:
          • Buhai Wang, Site 0378
          • Phone Number: 8613813194298
    • Jiangxi
      • Nanchang, Jiangxi, China, 330006
        • Recruiting
        • The Second Affiliated Hospital of Nanchang University
        • Contact:
          • Anwen Liu, Site 0467
          • Phone Number: 8613767120022
    • Jilin
      • Changchun, Jilin, China, 130021
        • Recruiting
        • The First Hospital of Jilin University
        • Contact:
          • Kewei Ma, Site 0483
          • Phone Number: 8613756060506
    • Liaoning
      • Shenyang, Liaoning, China, 110004
        • Recruiting
        • Shengjing Hospital Of China Medical University
        • Contact:
          • Xiaoye Zhang, Site 0479
          • Phone Number: 18940259600
      • Shenyang, Liaoning, China, 110001
        • Recruiting
        • The First Hospital of China Medical University
        • Contact:
          • Bo Jin, Site 0473
          • Phone Number: 13604923020
      • Shenyang, Liaoning, China, 110042
        • Recruiting
        • Liaoning Cancer Hospital
        • Contact:
          • Rui Ma, Site 0493
          • Phone Number: 13304006343
    • Shandong
      • Jinan, Shandong, China, 250117
        • Recruiting
        • Shandong Cancer Hospital
        • Contact:
          • Haiyong Wang, Site 0474
          • Phone Number: 15665878316
      • Linyi, Shandong, China, 276001
        • Recruiting
        • Linyi Cancer Hospital
        • Contact:
          • Jianhua Shi, Site 0359
          • Phone Number: +8615963998868
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200030
        • Recruiting
        • Shanghai Chest Hospital
        • Contact:
          • Hua Zhong, Site 0470
          • Phone Number: 13818200560
      • Shanghai, Shanghai Municipality, China, 200032
        • Withdrawn
        • Local Institution - 0381
      • Shanghai, Shanghai Municipality, China, 200120
        • Recruiting
        • Shanghai East Hospital
        • Contact:
          • Caicun Zhou, Site 0354
          • Phone Number: 8613301825532
    • Shanxi
      • Taiyuan, Shanxi, China, 030000
        • Recruiting
        • Shanxi Cancer Hospital
        • Contact:
          • Jianchun Duan, Site 0353
          • Phone Number: 86+13811259820
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • West China Hospital, Sichuan University
        • Contact:
          • Yongsheng Wang, Site 0384
          • Phone Number: 8618980602258
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • Sichuan Cancer Hospital
        • Contact:
          • Wenxiu Yao, Site 0667
          • Phone Number: 18908178836
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300052
        • Recruiting
        • Tianjin Medical University General Hospital
        • Contact:
          • Diansheng Zhong, Site 0460
          • Phone Number: 13821377353
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital
        • Contact:
          • Yun Fan, Site 0463
          • Phone Number: 8657188122188
      • Hangzhou, Zhejiang, China, 310003
        • Recruiting
        • The First Affiliated Hospital, Zhejiang University School of Medicine
        • Contact:
          • Yihong Shen, Site 0462
          • Phone Number: 13958106605
      • Hangzhou, Zhejiang, China, 310016
        • Recruiting
        • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
        • Contact:
          • Yong Fang, Site 0492
          • Phone Number: 8613588491264
      • Taizhou, Zhejiang, China, 317000
        • Recruiting
        • Taizhou Hospital of Zhejiang Province
        • Contact:
          • Dongqing LV, Site 0374
          • Phone Number: 13867622009
  • Colombia
      • Medellín, Colombia
        • Recruiting
        • Clinica Medellin S.A
        • Contact:
          • Andres Yepes, Site 0580
          • Phone Number: 573002608134
    • Antioquia
      • Rionegro, Antioquia, Colombia, 054040
        • Recruiting
        • Clinica Somer
        • Contact:
          • Camilo Vallejo, Site 0171
          • Phone Number: +573116349000
    • Atlántico
      • Puerto Colombia, Atlántico, Colombia, 81001
        • Withdrawn
        • Local Institution - 0191
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 110131
        • Withdrawn
        • Local Institution - 0189
    • COR
      • Montería, COR, Colombia, 230002
        • Recruiting
        • Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S
        • Contact:
          • José Lobatón Ramirez, Site 0167
          • Phone Number: 47854344
    • Cesar Department
      • Valledupar, Cesar Department, Colombia, 200001
        • Recruiting
        • Sociedad De Oncología y Hematología Del Cesar SAS
        • Contact:
          • Raimundo Manneh, Site 0253
          • Phone Number: 573157411877
    • Cundinamarca
      • Bogota, Cundinamarca, Colombia, 111151
        • Not yet recruiting
        • Local Institution - 0671
        • Contact:
          • Site 0671
    • Santander Department
      • Floridablanca, Santander Department, Colombia, 681004
        • Recruiting
        • Fundacion Cardiovascular de Colombia
        • Contact:
          • Martha Alarcon, Site 0170
          • Phone Number: 3187148911
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Recruiting
        • Fundación Valle del Lili
        • Contact:
          • Alvaro Osorio Franco, Site 0173
          • Phone Number: 573012895296
  • Croatia
      • Osijek, Croatia, 31000
        • Recruiting
        • Klinicki bolnicki centar Osijek
        • Contact:
          • Ivana Canjko, Site 0567
          • Phone Number: 385917223985
      • Zagreb, Croatia, 10000
        • Not yet recruiting
        • Local Institution - 0585
        • Contact:
          • Site 0585
    • Dubrovnik-Neretva County
      • Dubrovnik, Dubrovnik-Neretva County, Croatia, 20000
        • Recruiting
        • Opća bolnica Dubrovnik
        • Contact:
          • Tihana Boraska Jelavic, Site 0619
          • Phone Number: +385913458470
    • Primorje-Gorski Kotar County
      • Rijeka, Primorje-Gorski Kotar County, Croatia, 51000
        • Recruiting
        • Poliklinika MEDICO - Rijeka
        • Contact:
          • Dragan Trivanovic, Site 0664
          • Phone Number: 38598335797
    • Split-Dalmatia County
      • Split, Split-Dalmatia County, Croatia, 21000
        • Recruiting
        • Klinicki bolnicki centar Split
        • Contact:
          • Suzana Mladinov, Site 0639
          • Phone Number: +38521556434
  • France
      • Boulogne-Billancourt, France, 92100
        • Recruiting
        • Hôpital Ambroise Paré
        • Contact:
          • Etienne Giroux-Leprieur, Site 0513
      • Clermont-Ferrand, France, 63000
        • Recruiting
        • Chu Gabriel Montpied
        • Contact:
          • Patrick MERLE, Site 0134
          • Phone Number: 0473751649
      • Limoges, France, 87042
        • Recruiting
        • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
        • Contact:
          • Thomas Egenod, Site 0604
          • Phone Number: 33555056892
      • Marseille, France, 13915
        • Recruiting
        • Assistance Publique Hôpitaux de Marseille - Hôpital Nord
        • Contact:
          • Laurent Greillier, Site 0164
          • Phone Number: 33491324400
      • Paris, France, 75679
        • Recruiting
        • Hopitaux Universitaires Paris Centre-Hopital Cochin
        • Contact:
          • Marie Wislez, Site 0158
          • Phone Number: 33158413091
      • Paris, France, 75248
        • Withdrawn
        • Local Institution - 0133
      • Saint-Herblain, France, 44800
        • Recruiting
        • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
        • Contact:
          • Elvire Pons-Tostivint, Site 0139
          • Phone Number: +33676133810
    • Alsace
      • Mulhouse, Alsace, France, 68100
        • Withdrawn
        • Local Institution - 0159
    • Calvados
      • Caen, Calvados, France, 14076
        • Recruiting
        • Centre François Baclesse
        • Contact:
          • Hubert CURCIO, Site 0296
          • Phone Number: 0231455050
    • Côte-d'Or
      • Dijon, Côte-d'Or, France, 21079
        • Recruiting
        • Centre Georges François Leclerc
        • Contact:
          • Coureche Kaderbhai, Site 0605
          • Phone Number: 33380737504
    • Finistère
      • Brest, Finistère, France, 29200
        • Recruiting
        • CHRU de Brest
        • Contact:
          • Margaux Geier, Site 0512
          • Phone Number: 33298223333
    • Hérault
      • Montpellier, Hérault, France, 34298
        • Recruiting
        • Institut régional du Cancer Montpellier
        • Contact:
          • Xavier Quantin, Site 0558
          • Phone Number: 33467614533
    • Isère
      • La Tronche, Isère, France, 38700
        • Recruiting
        • Chu Grenoble Alpes
        • Contact:
          • Denis Moro-Sibilot, Site 0220
          • Phone Number: 33476765467
    • Maine-et-Loire
      • Angers, Maine-et-Loire, France, 49933
        • Recruiting
        • Centre Hospitalier Universitaire d'Angers
        • Contact:
          • Youssef Oulkhouir, Site 0560
          • Phone Number: 33231064676
    • Meurthe-et-Moselle
      • Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France, 54511
        • Recruiting
        • Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
        • Contact:
          • Bertrand Mennecier, Site 0589
          • Phone Number: 33383154653
    • Provence-Alpes-Côte d'Azur Region
      • Marseille, Provence-Alpes-Côte d'Azur Region, France, 13273
        • Recruiting
        • Institut Paoli-Calmettes
        • Contact:
          • Anne Madroszyk, Site 0636
          • Phone Number: 33491223789
    • Somme
      • Amiens, Somme, France, 80054
        • Recruiting
        • CHU d'Amiens-Picardie - Hôpital Sud
        • Contact:
          • Claire Poulet, Site 0552
          • Phone Number: 0322087990
    • Val-de-Marne
      • Villejuif, Val-de-Marne, France, 94800
        • Recruiting
        • Gustave Roussy
        • Contact:
          • Fabrice Barlesi, Site 0213
          • Phone Number: 33142114211
  • Germany
      • Berlin, Germany, 13125
        • Recruiting
        • Evangelische Lungenklinik Berlin
        • Contact:
          • Christian Grohe, Site 0537
          • Phone Number: +493094802112
      • Berlin, Germany, 12351
        • Recruiting
        • Vivantes Klinikum Neukölln
        • Contact:
          • Maike De Wit, Site 0526
          • Phone Number: 0000000000
      • Halle, Germany, 06110
        • Withdrawn
        • Local Institution - 0675
      • Hemer, Germany, 58675
        • Recruiting
        • Lungenklinik Hemer
        • Contact:
          • Karsten Schulmann, Site 0528
          • Phone Number: 02372-9082560
      • Stuttgart, Germany, 70174
        • Recruiting
        • Klinikum Stuttgart - Katharinenhospital
        • Contact:
          • Cornelia Kropf-Sanchen, Site 0517
          • Phone Number: +4973150045230
      • Würzburg, Germany, 97080
        • Recruiting
        • Universitaetsklinikum Wuerzburg
        • Contact:
          • Horst Hummel, Site 0525
          • Phone Number: 004993120140916
    • Baden-Wurttemberg
      • Esslingen am Neckar, Baden-Wurttemberg, Germany, 73730
        • Recruiting
        • Klinikum Esslingen
        • Contact:
          • Martin Faehling, Site 0534
          • Phone Number: +4971131032402
      • Ulm, Baden-Wurttemberg, Germany, 89081
        • Recruiting
        • Bundeswehrkrankenhaus Ulm
        • Contact:
          • Matthias Mueller, Site 0670
          • Phone Number: +490731171031253
    • Bavaria
      • München, Bavaria, Germany, 81377
        • Recruiting
        • Klinikum der Ludwig-Maximilians-Universitaet Muenchen
        • Contact:
          • Amanda Tufman, Site 0557
          • Phone Number: 4989440057545
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60389
        • Recruiting
        • Centrum fur Hamatologie und Onkologie Bethanien
        • Contact:
          • Oliver Waidmann, Site 0518
          • Phone Number: 06956005626
      • Giessen, Hesse, Germany, 35392
        • Recruiting
        • UKGM Gießen/Marburg
        • Contact:
          • Thomas Wehler, Site 0535
          • Phone Number: 0049064198558544
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30161
        • Recruiting
        • Praxis Onkologie am Raschplatz
        • Contact:
          • Eyck von der Heyde, Site 0520
          • Phone Number: 0177-6506614
      • Oldenburg, Lower Saxony, Germany, 26121
        • Recruiting
        • Pius Hospital Oldenburg
        • Contact:
          • Frank Griesinger, Site 0527
          • Phone Number: 494412291611
    • North Rhine-Westphalia
      • Cologne, North Rhine-Westphalia, Germany, 51109
        • Recruiting
        • Klinikum Köln-Merheim
        • Contact:
          • Carolin Groß-Ophoff-Müller, Site 0523
          • Phone Number: +49221890713962
      • Herne, North Rhine-Westphalia, Germany, 44651
        • Recruiting
        • Evangelisches Krankenhaus Herne - Eickel
        • Contact:
          • Daniel Christoph, Site 0603
          • Phone Number: +49232349892793
    • Saxony-Anhalt
      • Halle, Saxony-Anhalt, Germany, 06120
        • Recruiting
        • Universitatsklinikum Halle
        • Contact:
          • Stephan Eisenmann, Site 0522
          • Phone Number: +4903455591429
    • Schleswig-Holstein
      • Flensburg, Schleswig-Holstein, Germany, 24939
        • Recruiting
        • Malteser Krankenhaus St. Franziskus-Hospital
        • Contact:
          • Nicolai Faber, Site 0521
          • Phone Number: 04618162782
    • Thuringia
      • Gera, Thuringia, Germany, 07548
        • Recruiting
        • SRH Wald-Klinikum Gera GmbH
        • Contact:
          • Dagmar Täuscher, Site 0524
          • Phone Number: 493658287758
      • Jena, Thuringia, Germany, 07747
        • Recruiting
        • Universitatsklinikum Jena
        • Contact:
          • Jakob Hammersen, Site 0551
          • Phone Number: 4936419396622
  • Greece
    • Attikí
      • Athens, Attikí, Greece, 115 26
        • Recruiting
        • Errikos Dunant Hospital Center
        • Contact:
          • IOANNIS MOUNTZIOS, Site 0608
          • Phone Number: +306983519989
      • Athens, Attikí, Greece, 115 27
        • Recruiting
        • Thoracic General Hospital of Athens "I Sotiria"
        • Contact:
          • Konstantinos Syrigos, Site 0612
          • Phone Number: +302107700220
    • Thessalía
      • Larissa, Thessalía, Greece, 41110
        • Recruiting
        • University General Hospital of Larissa
        • Contact:
          • Athanasios Kotsakis, Site 0609
          • Phone Number: 302413502124
  • Hong Kong
      • Hksar, Hong Kong
        • Recruiting
        • Queen Mary Hospital
        • Contact:
          • Chung Man James Ho, Site 0379
          • Phone Number: 85222554999
  • Hungary
      • Budapest, Hungary, 1083
        • Recruiting
        • Semmelweis Egyetem
        • Contact:
          • Veronika Muller, Site 0151
          • Phone Number: 36208259181
      • Budapest, Hungary, 1121
        • Recruiting
        • Orszagos Koranyi Pulmonologiai Intezet
        • Contact:
          • Gyula Ostoros, Site 0140
          • Phone Number: 3613913213
      • Győr, Hungary, 9024
        • Recruiting
        • Petz Aladar Egyetemi Oktato Korhaz
        • Contact:
          • Zsuzsanna Szalai, Site 0601
          • Phone Number: +36309758356
    • Heves County
      • Gyöngyös - Mátraháza, Heves County, Hungary, 3233
        • Recruiting
        • Matrai Gyogyintezet
        • Contact:
          • Istvan Albert, Site 0144
          • Phone Number: 36202708215
    • Komárom-Esztergom
      • Tatabánya, Komárom-Esztergom, Hungary, 2800
        • Withdrawn
        • Local Institution - 0157
    • Veszprém megye
      • Farkasgyepű, Veszprém megye, Hungary, 8582
        • Recruiting
        • Farkasgyepui Tudogyogyintezet
        • Contact:
          • Zsolt Kiraly, Site 0143
          • Phone Number: 36209264476
  • India
      • Hyderabad, India, 500034
        • Recruiting
        • Basavatarakam Indo American Cancer Hospital & Research Institute
        • Contact:
          • Senthil Rajappa, Site 0661
          • Phone Number: 9849213102
    • Andhra Pradesh
      • Visakhapatnam, Andhra Pradesh, India, 530040
        • Recruiting
        • Apollo Hospitals - Visakhapatnam - Health City
        • Contact:
          • Rakesh Reddy Boya, Site 0222
          • Phone Number: 555-555-55
    • Gujarat
      • Ahmedabad, Gujarat, India, 380060
        • Recruiting
        • Marengo Cims Hospital
        • Contact:
          • Bhavesh Parekh, Site 0230
          • Phone Number: 9825034353
      • Ahmedabad, Gujarat, India, 380054
        • Recruiting
        • Hemato Oncology Clinic
        • Contact:
          • Chirag Desai, Site 0136
          • Phone Number: 919824047561
    • Kerala
      • Thiruvananthapuram, Kerala, India, 695011
        • Not yet recruiting
        • Local Institution - 0155
        • Contact:
          • Site 0155
    • Maharashtra
      • Mumbai, Maharashtra, India, 400012
        • Not yet recruiting
        • Local Institution - 0154
        • Contact:
          • Site 0154
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110085
        • Recruiting
        • Rajiv Gandhi Cancer Institute and Research Centre
        • Contact:
          • Ullas Batra, Site 0135
          • Phone Number: 919711080001
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Not yet recruiting
        • Local Institution - 0312
        • Contact:
          • Site 0312
      • New Delhi, National Capital Territory of Delhi, India, 110029
        • Not yet recruiting
        • Local Institution - 0511
        • Contact:
          • Site 0511
    • Odisha
      • Bhubaneswar, Odisha, India, 751003
        • Recruiting
        • Institute of Medical Sciences and Sum Hospital
        • Contact:
          • Lalatendu Moharana, Site 0226
          • Phone Number: 9538752579
    • Tamil Nadu
      • Madurai, Tamil Nadu, India, 625107
        • Recruiting
        • Meenakshi Mission Hospital and Research Centre
        • Contact:
          • Saju SV, Site 0224
          • Phone Number: 8891810070
    • Telangana
      • Hyderabad, Telangana, India, 500084
        • Recruiting
        • Yashoda Hospitals - Hitech City
        • Contact:
          • Naidu Norman Bethune, Site 0663
          • Phone Number: 9989489877
    • Uttar Pradesh
      • Varanasi, Uttar Pradesh, India, 221005
        • Not yet recruiting
        • Local Institution - 0153
        • Contact:
          • Site 0153
    • West Bengal
      • Howrah, West Bengal, India, 711103
        • Recruiting
        • Narayana Superspecialty Hospital
        • Contact:
          • Chandrakanth MV, Site 0161
          • Phone Number: 7738519198
      • Kolkata, West Bengal, India, 700094
        • Recruiting
        • Netaji Subhas Chandra Bose Cancer Hospital
        • Contact:
          • Rajiv Jena, Site 0221
          • Phone Number: 86177756659
  • Ireland
      • Cork, Ireland, T12 E8YV
        • Recruiting
        • Cork University Hospital
        • Contact:
          • Sinéad Noonan, Site 0102
          • Phone Number: +353879680182
      • Dublin, Ireland, D08 E9P6
        • Recruiting
        • St. James's Hospital
        • Contact:
          • Sinead Cuffe, Site 0101
          • Phone Number: 35314103756
      • Dublin, Ireland, D9
        • Recruiting
        • Beaumont Hospital, Dublin
        • Contact:
          • Jarushka Naidoo, Site 0106
          • Phone Number: 01-8092010
      • Dublin, Ireland, D18 AK68
        • Recruiting
        • UCD School of Medicine Beacon Hospital
        • Contact:
          • Lisa Prior, Site 0100
          • Phone Number: +35312935666
      • Dublin, Ireland, D07 WKW8
        • Recruiting
        • Mater Private Hospital - Dublin
        • Contact:
          • Jane Sui, Site 0476
          • Phone Number: +353(1)8034831
  • Israel
    • Central District
      • Petah Tikva, Central District, Israel, 4941492
        • Recruiting
        • Rabin Medical Center
        • Contact:
          • Ofer Rotem, Site 0597
          • Phone Number: 9729378146
      • Ramat Gan, Central District, Israel, 5265601
        • Recruiting
        • Sheba Medical Center
        • Contact:
          • Jair Bar, Site 0596
          • Phone Number: 97235307096
      • Ẕerifin, Central District, Israel, 70300
        • Recruiting
        • Yitzhak Shamir Medical Center
        • Contact:
          • Carmell Fink, Site 0600
          • Phone Number: +97289779713
    • Jerusalem
      • Jerusalem, Jerusalem, Israel, 9112001
        • Recruiting
        • Hadassah Medical Center
        • Contact:
          • Hovav Nechushtan, Site 0544
          • Phone Number: 97226777836
    • Ḥeifā
      • Haifa, Ḥeifā, Israel, 3436212
        • Recruiting
        • Carmel Hospital
        • Contact:
          • Ilit Turgeman, Site 0613
          • Phone Number: 04-8844420
  • Italy
      • Genova, Italy, 16132
        • Recruiting
        • Ospedale San Martino
        • Contact:
          • Carlo Genova, Site 0588
          • Phone Number: 393397231066
      • Padova, Italy, 35128
        • Recruiting
        • Istituto Oncologico Veneto IRCCS
        • Contact:
          • Valentina Guarneri, Site 0073
          • Phone Number: 00390498215931
      • Parma, Italy, 43126
        • Recruiting
        • Azienda Ospedaliero Universitaria di Parma
        • Contact:
          • Marcello Tiseo, Site 0156
          • Phone Number: 390521702682
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione IRCCS Policlinico San Matteo
        • Contact:
          • Francesco Agustoni, Site 0543
          • Phone Number: 0382503938
      • Varese, Italy, 21100
        • Not yet recruiting
        • Local Institution - 0556
        • Contact:
          • Site 0556
    • Apulia
      • Bari, Apulia, Italy, 70124
        • Recruiting
        • Instituto Tumori Giovanni Paolo II
        • Contact:
          • Domenico Galetta, Site 0071
          • Phone Number: 390805555442
    • Emilia-Romagna
      • Meldola, Emilia-Romagna, Italy, 47014
        • Recruiting
        • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
        • Contact:
          • Angelo Delmonte, Site 0067
          • Phone Number: +393487469100
    • Napoli
      • Naples, Napoli, Italy, 80131
        • Recruiting
        • A.O.R.N. Ospedale dei Colli - Monaldi V.
        • Contact:
          • Danilo Rocco, Site 0066
          • Phone Number: 390817064300
    • Piedmont
      • Orbassano, Piedmont, Italy, 10043
        • Recruiting
        • Azienda Ospedaliero-Universitaria San Luigi Gonzaga
        • Contact:
          • Silvia Novello, Site 0070
          • Phone Number: 390119026322
    • Roma
      • Rome, Roma, Italy, 00144
        • Recruiting
        • Istituto Nazionale Tumori Regina Elena
        • Contact:
          • Federico Capuzzo, Site 0068
          • Phone Number: +390516225126
    • Tuscany
      • Florence, Tuscany, Italy, 50134
        • Recruiting
        • Azienda Ospedaliera Universitaria Careggi
        • Contact:
          • Lorenzo Antonuzzo, Site 0069
          • Phone Number: 00390557947298
  • Japan
      • Akashi, Japan, 6738558
        • Withdrawn
        • Local Institution - 0307
      • Aomori, Japan, 030-8553
        • Recruiting
        • Aomori Prefectural Central Hospital
        • Contact:
          • Takeshi Morimoto, Site 0346
          • Phone Number: 017-726-8111
      • Fukuoka, Japan, 812-8582
        • Recruiting
        • Kyushu University Hospital
        • Contact:
          • Isamu Okamoto, Site 0310
          • Phone Number: +81926425378
      • Fukushima, Japan, 960-1295
        • Withdrawn
        • Local Institution - 0367
      • Kumamoto, Japan, 861-4193
        • Withdrawn
        • Local Institution - 0308
      • Nagasaki, Japan, 852-8501
        • Recruiting
        • Nagasaki University Hospital
        • Contact:
          • Takemoto Shinnosuke, Site 0687
          • Phone Number: 8195-819-7273
      • Osaka, Japan, 541-8567
        • Recruiting
        • Osaka International Cancer Institute
        • Contact:
          • Motohiro Tamiya, Site 0309
          • Phone Number: +81-6-6945-1181
      • Osaka, Japan, 534-0021
        • Recruiting
        • Osaka City General Hospital
        • Contact:
          • Haruko Daga, Site 0297
          • Phone Number: 81669293269
    • Aichi-ken
      • Nagoya, Aichi-ken, Japan, 457-8510
        • Not yet recruiting
        • Local Institution - 0607
        • Contact:
          • Site 0607
      • Nagoya, Aichi-ken, Japan, 460-0001
        • Not yet recruiting
        • Local Institution - 0305
        • Contact:
          • Site 0305
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 0608648
        • Recruiting
        • Hokkaido University Hospital
        • Contact:
          • Jun Sakakibara, Site 0298
          • Phone Number: +81-11-716-1161
    • Ishikawa-ken
      • Kanazawa, Ishikawa-ken, Japan, 920-8641
        • Withdrawn
        • Local Institution - 0304
    • Kanagawa
      • Sagamihara, Kanagawa, Japan, 252-0375
        • Recruiting
        • Kitasato University Hospital
        • Contact:
          • Katsuhiko Naoki, Site 0302
          • Phone Number: +81-80-5057-3533
      • Yokohama, Kanagawa, Japan, 221-0855
        • Withdrawn
        • Local Institution - 0369
    • Miyagi
      • Sendai, Miyagi, Japan, 9810914
        • Recruiting
        • Sendai Kousei Hospital
        • Contact:
          • Shunichi Sugawara, Site 0301
          • Phone Number: 81227288000
    • Nara
      • Kashihara, Nara, Japan, 634-0813
        • Withdrawn
        • Local Institution - 0306
    • Okayama-ken
      • Kurashiki, Okayama-ken, Japan, 710-8602
        • Withdrawn
        • Local Institution - 0368
    • Osaka
      • Hirakata, Osaka, Japan, 573-1191
        • Not yet recruiting
        • Local Institution - 0642
        • Contact:
          • Site 0642
    • Saitama
      • Hidaka, Saitama, Japan, 350-1298
        • Recruiting
        • Saitama Medical University International Medical Center
        • Contact:
          • Hiroshi Kagamu, Site 0303
          • Phone Number: 819014217189
      • Ina-machi, Saitama, Japan, 362-0806
        • Withdrawn
        • Local Institution - 0300
    • Shizuoka
      • Hamamatsu, Shizuoka, Japan, 431-3192
        • Recruiting
        • Hamamatsu University Hospital
        • Contact:
          • Naoki Inui, Site 0606
          • Phone Number: 81534352356
    • Tochigi
      • Shimotsuga, Tochigi, Japan, 321-0293
        • Withdrawn
        • Local Institution - 0299
    • Tokyo
      • Bunkyo Ku, Tokyo, Japan, 113-8677
        • Recruiting
        • Tokyo Metropolitan Komagome Hospital
        • Contact:
          • Yukio Hosomi, Site 0674
          • Phone Number: 81338232101
    • Toyama
      • Toyoma, Toyama, Japan, 930-0194
        • Recruiting
        • Toyama University Hospital
        • Contact:
          • Ryuji Hayashi, Site 0343
          • Phone Number: +81763437808
    • Yamaguchi
      • Iwakuni, Yamaguchi, Japan, 740-8510
        • Withdrawn
        • Local Institution - 0542
  • Mexico
      • Chihuahua City, Mexico, 31217
        • Withdrawn
        • Local Institution - 0175
      • Puebla City, Mexico, 72424
        • Recruiting
        • Unidad Médica Onco-hematológica
        • Contact:
          • MIRIAM ESCAMILLA, Site 0181
          • Phone Number: +522222154940
      • Puebla City, Mexico, 72530
        • Withdrawn
        • Local Institution - 0638
      • Veracruz, Mexico, 91900
        • Not yet recruiting
        • Local Institution - 0180
        • Contact:
          • Site 0180
    • Coahuila
      • Saltillo, Coahuila, Mexico, 25279
        • Recruiting
        • Centro de Infusion E Investigacion Oncologia de Saltillo S.C.
        • Contact:
          • Eva Willars, Site 0583
          • Phone Number: 8446887477
    • DIF
      • Mexico City, DIF, Mexico, 11510
        • Recruiting
        • Gefarma (Atrys)
        • Contact:
          • Patricia Sánchez Valencia, Site 0176
          • Phone Number: 5514743371
    • Hidalgo
      • Pachuca, Hidalgo, Mexico, 42000
        • Recruiting
        • Grupo Ollin Care
        • Contact:
          • Juan Salinas Garcia, Site 0579
          • Phone Number: 7711996481
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44280
        • Recruiting
        • Hospital Civil Fray Antonio Alcalde
        • Contact:
          • Juan Vazquez Limon, Site 0178
          • Phone Number: 523316063096
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64040
        • Recruiting
        • Axis Heilsa S. de R.L. de C.V.
        • Contact:
          • Jorge Rodriguez Olivo, Site 0591
          • Phone Number: 8115545104
  • Netherlands
    • Limburg
      • Maastricht, Limburg, Netherlands, 6229 HX
        • Recruiting
        • Maastricht UMC+
        • Contact:
          • Lizza Hendriks, Site 0615
          • Phone Number: 31433875051
    • North Holland
      • Amsterdam, North Holland, Netherlands, 1066 CX
        • Recruiting
        • Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
        • Contact:
          • willemijn Theelen, Site 0594
          • Phone Number: 06-xxxxxxxx
  • Poland
      • Bydgoszcz, Poland, 85796
        • Recruiting
        • Centrum Onkologii im. Prof. Franciszka Lukaszczyka
        • Contact:
          • Bogdan Zurawski, Site 0076
          • Phone Number: 48501446778
      • Katowice, Poland, 40-519
        • Recruiting
        • Pratia Onkologia Katowice
        • Contact:
          • Agata Kachel-Flis, Site 0078
          • Phone Number: +48501714019
      • Prabuty, Poland, 82-550
        • Recruiting
        • Szpital Specjalistyczny w Prabutach Spolka z o.o.
        • Contact:
          • Anna Lowczak, Site 0077
          • Phone Number: +48503022396
    • Greater Poland Voivodeship
      • Poznan, Greater Poland Voivodeship, Poland, 60-693
        • Recruiting
        • Med-Polonia Sp. z o. o.
        • Contact:
          • Rodryg Ramlau, Site 0209
          • Phone Number: 48618549040
    • Lesser Poland Voivodeship
      • Gorlice, Lesser Poland Voivodeship, Poland, 38-300
        • Recruiting
        • Szpital Specjalistyczny im. Henryka Klimontowicza
        • Contact:
          • Łukasz Pierzchała, Site 0206
          • Phone Number: +48501455396
      • Krakow, Lesser Poland Voivodeship, Poland, 30-727
        • Recruiting
        • Pratia MCM Krakow
        • Contact:
          • Anna Drosik Kwasniewska, Site 0079
          • Phone Number: 48505169040
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 53-439
        • Recruiting
        • Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii
        • Contact:
          • Krzysztof Rogoziewicz, Site 0205
          • Phone Number: 48693997463
    • Lublin Voivodeship
      • Lublin, Lublin Voivodeship, Poland, 20-090
        • Recruiting
        • Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie
        • Contact:
          • Izabela Chmielewska, Site 0080
          • Phone Number: +504051512
  • Portugal
      • Coimbra, Portugal, 3000-075
        • Recruiting
        • Instituto Portugês de Oncologia de Coimbra Francisco Gentil
        • Contact:
          • Sara Povoa, Site 0510
      • Porto, Portugal, 4099-001
        • Recruiting
        • Centro Hospitalar do Porto - Hospital de Santo António
        • Contact:
          • Antonio Araujo, Site 0553
          • Phone Number: 351222077500x1729
    • Lisbon District
      • Lisbon, Lisbon District, Portugal, 1099-023
        • Recruiting
        • Instituto Portugues De Oncologia De Lisboa Francisco Gentil
        • Contact:
          • Telma Sequeira, Site 0509
          • Phone Number: 914000669
  • Romania
      • Cluj-Napoca, Romania, 400015
        • Recruiting
        • Institutul Oncologic Cluj
        • Contact:
          • Cristina Cebotaru, Site 0270
          • Phone Number: 40745976913
      • Constanța, Romania, 900591
        • Recruiting
        • Affidea Constanța
        • Contact:
          • MONICA LAZAR, Site 0590
          • Phone Number: 0744654976
      • Iași, Romania, 700106
        • Recruiting
        • S.C. Centrul de Oncologie Euroclinic S.R.L.
        • Contact:
          • Constantin Volovat, Site 0266
          • Phone Number: 40746110096
      • Iași, Romania, 700483
        • Recruiting
        • Institutul Regional de Oncologie
        • Contact:
          • Dana Clement, Site 0260
          • Phone Number: 40744692062
      • Ploieşti, Romania, 100337
        • Recruiting
        • Spitalul Municipal Schuller Ploiești
        • Contact:
          • Nita Amedeia, Site 0269
          • Phone Number: +40728121201
    • Bucharest
      • Bucharest, Bucharest, Romania, 013812
        • Recruiting
        • SC Memorial Healthcare International SRL
        • Contact:
          • Ingrid Iordan, Site 0272
          • Phone Number: 40721298677
      • Bucharest, Bucharest, Romania, 022338
        • Recruiting
        • Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
        • Contact:
          • Aurelia Alexandru, Site 0261
          • Phone Number: 40723289606
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400015
        • Recruiting
        • Cardiomed SRL Cluj-Napoca
        • Contact:
          • Calin Cainap, Site 0276
          • Phone Number: 0040724543672
      • Florești, Cluj, Romania, 407280
        • Recruiting
        • SC Radiotherapy Center Cluj SRL
        • Contact:
          • Andrei Ungureanu, Site 0268
          • Phone Number: 40742206212
    • Constanța County
      • Ovidiu, Constanța County, Romania, 905900
        • Recruiting
        • Ovidius Clinical Hospital OCH
        • Contact:
          • Laura Mazilu, Site 0275
          • Phone Number: +40724877013
    • Dolj
      • Craiova, Dolj, Romania, 200542
        • Recruiting
        • Centrul de Oncologie "Sfântul Nectarie"
        • Contact:
          • Michael Schenker, Site 0271
          • Phone Number: 40727774974
    • Timiș County
      • Timișoara, Timiș County, Romania, 300239
        • Recruiting
        • Cabinet Medical Oncomed
        • Contact:
          • Daniela Sirbu, Site 0592
          • Phone Number: 40744571617
  • Saudi Arabia
      • Riyadh, Saudi Arabia, 11426
        • Not yet recruiting
        • Local Institution - 0602
        • Contact:
          • Site 0602
      • Riyadh, Saudi Arabia, 12713
        • Recruiting
        • King Faisal Specialist Hospital and Research Center
        • Contact:
          • Hamed Alhusaini, Site 0562
          • Phone Number: +9664647272-49769
    • Makkah Al Mukarramah
      • Jeddah, Makkah Al Mukarramah, Saudi Arabia, 23433
        • Not yet recruiting
        • Local Institution - 0614
        • Contact:
          • Site 0614
  • South Korea
    • Chungcheongbuk-do [Chungbuk]
      • Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea, 28644
        • Recruiting
        • Chungbuk National University Hospital
        • Contact:
          • Ki Hyeong Lee, Site 0163
          • Phone Number: 82432696015
    • Incheon-gwangyeoksi [Incheon]
      • Namdong-gu, Incheon-gwangyeoksi [Incheon], South Korea, 21565
        • Recruiting
        • Gachon University Gil Medical Center
        • Contact:
          • Eun Kyung Cho, Site 0227
          • Phone Number: 82324603383
    • Kyǒngsangnam-do
      • Yangsan, Kyǒngsangnam-do, South Korea, 50612
        • Recruiting
        • Pusan National University Yangsan Hospital
        • Contact:
          • Seong Hoon Yoon, Site 0211
          • Phone Number: 82-10-2870-9389
    • Pusan-Kwangyǒkshi
      • Busan, Pusan-Kwangyǒkshi, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital
        • Contact:
          • Jung Seop Eom, Site 0186
          • Phone Number: +82512407889
    • Seoul-teukbyeolsi [Seoul]
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Contact:
          • Min Hee Hong, Site 0165
          • Phone Number: 821071541554
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 05030
        • Recruiting
        • Konkuk University Medical Center
        • Contact:
          • Kyeyoung Lee, Site 0228
          • Phone Number: +821088963916
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 08308
        • Recruiting
        • Korea University Guro Hospital
        • Contact:
          • Sung Yong Lee, Site 0146
          • Phone Number: 821022179216
      • Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 06591
        • Completed
        • Local Institution - 0248
  • Spain
      • Madrid, Spain, 28040
        • Recruiting
        • Hospital Clinico San Carlos
        • Contact:
          • Carlos Aguado de la Rosa, Site 0504
          • Phone Number: +34913307552
      • Málaga, Spain, 29011
        • Recruiting
        • H.R.U Málaga - Hospital General
        • Contact:
          • Manuel Cobo-Dols, Site 0502
          • Phone Number: 00349422033350000
      • Seville, Spain, 41013
        • Recruiting
        • Hospital Universitario Virgen del Rocio
        • Contact:
          • Miriam Alonso Garcia, Site 0507
          • Phone Number: 34955013068
      • Valencia, Spain, 46026
        • Withdrawn
        • Local Institution - 0495
    • A Coruña [La Coruña]
      • A Coruña, A Coruña [La Coruña], Spain, 15006
        • Recruiting
        • CHUAC-Hospital Teresa Herrera
        • Contact:
          • Maria Garcia Campelo, Site 0499
          • Phone Number: 34981178353
      • Santiago de Compostela, A Coruña [La Coruña], Spain, 15706
        • Recruiting
        • CHUS - Hospital Clinico Universitario
        • Contact:
          • Jorge Garcia Gonzalez, Site 0506
          • Phone Number: 34981950511
    • Barcelona [Barcelona]
      • Barcelona, Barcelona [Barcelona], Spain, 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebron
        • Contact:
          • Enriqueta Felip Font, Site 0501
          • Phone Number: 34932746077
      • Hospitalet, Barcelona [Barcelona], Spain, 08907
        • Withdrawn
        • Local Institution - 0497
    • Catalunya [Cataluña]
      • Barcelona, Catalunya [Cataluña], Spain, 08036
        • Withdrawn
        • Local Institution - 0505
    • Illes Balears [Islas Baleares]
      • Palma, Illes Balears [Islas Baleares], Spain, 07198
        • Recruiting
        • Hospital Son Llàtzer
        • Contact:
          • Juan Coves Sarto, Site 0508
          • Phone Number: 348712020001629
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, Spain, 28034
        • Recruiting
        • Hospital Universitario Ramon y Cajal
        • Contact:
          • Maria Eugenia Olmedo Garcia, Site 0503
          • Phone Number: 34913368263
      • Madrid, Madrid, Comunidad de, Spain, 28041
        • Recruiting
        • Hospital Universitario 12 de Octubre
        • Contact:
          • Luis Paz-Ares Rodriguez, Site 0496
          • Phone Number: 0034913908922
      • Madrid, Madrid, Comunidad de, Spain, 28009
        • Recruiting
        • Hospital General Universitario Gregorio Marañon
        • Contact:
          • Antonio Calles Blanco, Site 0500
          • Phone Number: +34915868115
      • Majadahonda, Madrid, Comunidad de, Spain, 28222
        • Recruiting
        • Hospital Universitario Puerta de Hierro Majadahonda
        • Contact:
          • Mariano Provencio Pulla, Site 0498
          • Phone Number: 34911917759
    • Pontevedra [Pontevedra]
      • Pontevedra, Pontevedra [Pontevedra], Spain, 36312
        • Recruiting
        • CHUVI- Hospital Alvaro Cunqueiro
        • Contact:
          • Martin Lazaro Quintela, Site 0669
          • Phone Number: 34986825801
    • València
      • Valencia, València, Spain, 46015
        • Recruiting
        • Hospital Arnau de Vilanova
        • Contact:
          • Jose Garcia Sanchez, Site 0640
          • Phone Number: +34963987700
  • Switzerland
      • Münsterlingen, Switzerland, 8596
        • Recruiting
        • Kantonsspital Münsterlingen - Spital Thurgau AG
        • Contact:
          • Ioannis Metaxas, Site 0536
          • Phone Number: +41581447850
  • Taiwan
      • New Taipei City, Taiwan, 235
        • Recruiting
        • Taipei Medical University Shuang Ho Hospital
        • Contact:
          • Kang-Yun Lee, Site 0337
          • Phone Number: 8862224900882714
      • Tainan, Taiwan, 704
        • Recruiting
        • National Cheng Kung University Hospital
        • Contact:
          • Chun-Hui Lee, Site 0335
          • Phone Number: 886-912777918
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
        • Contact:
          • Jin-Yuan Shih, Site 0331
          • Phone Number: 88622312345662905
    • Tainan
      • Tainan, Tainan, Taiwan, 73657
        • Recruiting
        • Chi Mei Hospital - Liouying Branch
        • Contact:
          • Sheng-Yen Hsiao, Site 0341
          • Phone Number: 88666226999
    • Taipei
      • Taipei City, Taipei, Taiwan, 114
        • Recruiting
        • Tri-Service General Hospital
        • Contact:
          • Chen-Liang Tsai, Site 0631
          • Phone Number: 886287923311
  • Thailand
    • Bangkok
      • Bangkok, Bangkok, Thailand, 10330
        • Recruiting
        • Chulalongkorn University
        • Contact:
          • Virote Sriuranpong, Site 0563
          • Phone Number: 6622564533
    • Changwat Khon Kaen
      • Muang, Changwat Khon Kaen, Thailand, 40002
        • Recruiting
        • Faculty of Medicine - Khon Kaen University
        • Contact:
          • Aumkhae Sookprasert, Site 0565
          • Phone Number: 66840292822
    • Changwat Songkhla
      • Hat Yai, Changwat Songkhla, Thailand, 90110
        • Recruiting
        • Songklanagarind Hospital
        • Contact:
          • Patrapim Sunpaweravong, Site 0564
          • Phone Number: 6674451469
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01250
        • Not yet recruiting
        • Local Institution - 0197
        • Contact:
          • Site 0197
      • Ankara, Turkey (Türkiye), 06620
        • Recruiting
        • Ankara University Health Practice and Research Hospitals
        • Contact:
          • Yuksel Urun, Site 0194
          • Phone Number: 05337483275
      • Ankara, Turkey (Türkiye), 06800
        • Recruiting
        • Ankara Bilkent Sehir Hastanesi
        • Contact:
          • Mehmet Ali Nahit Sendur, Site 0198
          • Phone Number: 905555306271
      • Ankara, Turkey (Türkiye), 06230
        • Recruiting
        • Hacettepe Universite Hastaneleri
        • Contact:
          • Mustafa Erman, Site 0201
          • Phone Number: +905334318506
      • Istanbul, Turkey (Türkiye), 34722
        • Recruiting
        • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
        • Contact:
          • Mahmut Gumus, Site 0549
          • Phone Number: 00905063509061
      • Istanbul, Turkey (Türkiye), 34180
        • Not yet recruiting
        • Local Institution - 0550
        • Contact:
          • Site 0550
      • Izmir, Turkey (Türkiye), 35100
        • Not yet recruiting
        • Local Institution - 0200
        • Contact:
          • Site 0200
    • İzmir
      • Izmir, Karsiyaka, İzmir, Turkey (Türkiye), 009035575
        • Not yet recruiting
        • Local Institution - 0199
        • Contact:
          • Site 0199
  • United Kingdom
      • Birmingham, United Kingdom, B9 5SS
        • Recruiting
        • Heartlands Hospital
        • Contact:
          • Shobhit Baijal, Site 0092
          • Phone Number: +(44)01214247456
      • Guildford, United Kingdom, GU2 7XX
        • Withdrawn
        • Local Institution - 0545
      • Guildford, United Kingdom, GU2 7XX
        • Recruiting
        • The Royal Surrey County Hospital
        • Contact:
          • Ajay Mehta, Site 0090
          • Phone Number: 441483571122
      • Manchester, United Kingdom, M20 4BX
        • Withdrawn
        • Local Institution - 0093
    • London, City of
      • London, London, City of, United Kingdom, NW1 2PG
        • Recruiting
        • University College London Hospital
        • Contact:
          • Siow Lee, Site 0088
          • Phone Number: 442034479091
      • London, London, City of, United Kingdom, SE1 9RT
        • Recruiting
        • Guy's & St Thomas' NHS Foundation Trust
        • Contact:
          • Alexandros Georgiou, Site 0091
          • Phone Number: 00442071882006
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35294
        • Not yet recruiting
        • Local Institution - 0347
        • Contact:
          • Site 0347
    • Arkansas
      • Springdale, Arkansas, United States, 72762
        • Not yet recruiting
        • Local Institution - 0686
        • Contact:
          • Site 0686
    • California
      • Fullerton, California, United States, 92835
        • Not yet recruiting
        • Local Institution - 0581
        • Contact:
          • Site 0581
      • Loma Linda, California, United States, 92354
        • Not yet recruiting
        • Local Institution - 0682
        • Contact:
          • Site 0682
      • Long Beach, California, United States, 90805
        • Recruiting
        • Helios Clinical Research
        • Contact:
          • Omkar Marathe, Site 0202
          • Phone Number: 562-693-4477
    • Colorado
      • Denver, Colorado, United States, 80206
        • Not yet recruiting
        • Local Institution - 0442
        • Contact:
          • Site 0442
    • Delaware
      • Newark, Delaware, United States, 19713
        • Not yet recruiting
        • Local Institution - 0701
        • Contact:
          • Site 0701
    • Florida
      • Clearwater, Florida, United States, 33756
        • Not yet recruiting
        • Local Institution - 0694
        • Contact:
          • Site 0694
      • Jacksonville, Florida, United States, 32256
        • Recruiting
        • Cancer Specialists of North Florida
        • Contact:
          • Laura Lourdes, Site 0052
          • Phone Number: 904-538-4488
      • Miami, Florida, United States, 33176
        • Not yet recruiting
        • Local Institution - 0696
        • Contact:
          • Site 0696
      • Ocala, Florida, United States, 34474
        • Not yet recruiting
        • Local Institution - 0680
        • Contact:
          • Site 0680
      • Orange City, Florida, United States, 32763
        • Recruiting
        • Mid Florida Hematology and Oncology Center
        • Contact:
          • Santosh Nair, Site 0679
          • Phone Number: 407-353-1915
      • Palm Bay, Florida, United States, 32901
        • Recruiting
        • Cancer Care Centers of Brevard, Inc.
        • Contact:
          • venkat pavan kancharla, Site 0621
          • Phone Number: 111-111-1111
      • Plantation, Florida, United States, 33322
        • Recruiting
        • Florida Clinical Trials Group.
        • Contact:
          • Harshad Amin, Site 0365
          • Phone Number: 561-447-0614
      • St. Petersburg, Florida, United States, 33705
        • Not yet recruiting
        • Local Institution - 0695
        • Contact:
          • Site 0695
      • Tamarac, Florida, United States, 33321
        • Recruiting
        • Florida Clinical Trials Group.
        • Contact:
          • Chintan Gandhi, Site 0377
          • Phone Number: 561-447-0614
      • Tampa, Florida, United States, 33612
        • Not yet recruiting
        • Local Institution - 0647
        • Contact:
          • Site 0647
      • Tampa, Florida, United States, 33612
        • Not yet recruiting
        • Local Institution - 0699
        • Contact:
          • Site 0699
    • Georgia
      • Marietta, Georgia, United States, 30060
        • Recruiting
        • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
        • Contact:
          • Walid Shaib, Site 0031
          • Phone Number: 770-281-5124
    • Illinois
      • Arlington Heights, Illinois, United States, 60005
        • Recruiting
        • Illinois Cancer Specialists
        • Contact:
          • David Hakimian, Site 0665
          • Phone Number: 847-827-9060
      • Chicago, Illinois, United States, 60612
        • Not yet recruiting
        • Local Institution - 0676
        • Contact:
          • Site 0676
      • Springfield, Illinois, United States, 62703
        • Not yet recruiting
        • Local Institution - 0683
        • Contact:
          • Site 0683
    • Indiana
      • Dyer, Indiana, United States, 46311
        • Not yet recruiting
        • Local Institution - 0454
        • Contact:
          • Site 0454
      • Fort Wayne, Indiana, United States, 46845
        • Not yet recruiting
        • Local Institution - 0684
        • Contact:
          • Site 0684
      • Munster, Indiana, United States, 46321
        • Withdrawn
        • Local Institution - 0423
    • Iowa
      • Cedar Rapids, Iowa, United States, 52403
        • Recruiting
        • Mercy Medical Center
        • Contact:
          • Ann Stroh, Site 0691
    • Kentucky
      • Edgewood, Kentucky, United States, 41017
        • Not yet recruiting
        • Local Institution - 0366
        • Contact:
          • Site 0366
      • Louisville, Kentucky, United States, 40202
        • Not yet recruiting
        • Local Institution - 0566
        • Contact:
          • Site 0566
      • Owensboro, Kentucky, United States, 42303
        • Not yet recruiting
        • Local Institution - 0693
        • Contact:
          • Site 0693
      • Paducah, Kentucky, United States, 42003
        • Not yet recruiting
        • Local Institution - 0698
        • Contact:
          • Site 0698
    • Louisiana
      • Shreveport, Louisiana, United States, 71103
        • Not yet recruiting
        • Local Institution - 0644
        • Contact:
          • Site 0644
    • Maryland
      • Annapolis, Maryland, United States, 21401
        • Not yet recruiting
        • Local Institution - 0702
        • Contact:
          • Site 0702
      • Columbia, Maryland, United States, 21044
        • Recruiting
        • Maryland Oncology Hematology - Columbia
        • Contact:
          • Mohit Narang, Site 0385
          • Phone Number: 817-837-8660
    • Massachusetts
      • Boston, Massachusetts, United States, 02215
        • Not yet recruiting
        • Local Institution - 0019
        • Contact:
          • Site 0019
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Not yet recruiting
        • Local Institution - 0293
        • Contact:
          • Site 0293
    • Missouri
      • Fenton, Missouri, United States, 63026
        • Not yet recruiting
        • Local Institution - 0685
        • Contact:
          • Site 0685
    • New York
      • Cooperstown, New York, United States, 13326
        • Not yet recruiting
        • Local Institution - 0678
        • Contact:
          • Site 0678
      • Rochester, New York, United States, 14642
        • Not yet recruiting
        • Local Institution - 0689
        • Contact:
          • Site 0689
      • Schenectady, New York, United States, 12308
        • Recruiting
        • Ellis Hospital
        • Contact:
          • Tallat Mahmood, Site 0634
          • Phone Number: 517-331-4405
      • White Plains, New York, United States, 10601
        • Not yet recruiting
        • Local Institution - 0618
        • Contact:
          • Site 0618
    • North Carolina
      • Asheville, North Carolina, United States, 28806
        • Not yet recruiting
        • Local Institution - 0624
        • Contact:
          • Site 0624
      • Salisbury, North Carolina, United States, 28144
        • Not yet recruiting
        • Local Institution - 0672
        • Contact:
          • Site 0672
    • Pennsylvania
      • Easton, Pennsylvania, United States, 18045
        • Not yet recruiting
        • Local Institution - 0688
        • Contact:
          • Site 0688
      • Hershey, Pennsylvania, United States, 17033
        • Not yet recruiting
        • Local Institution - 0376
        • Contact:
          • Site 0376
      • York, Pennsylvania, United States, 17403
        • Recruiting
        • WellSpan Oncology Research
        • Contact:
          • Ikechukwu Akunyili, Site 0657
          • Phone Number: 717-339-2560
    • South Carolina
      • Greenville, South Carolina, United States, 29607
        • Not yet recruiting
        • Local Institution - 0658
        • Contact:
          • Site 0658
      • Greenville, South Carolina, United States, 29605
        • Withdrawn
        • Local Institution - 0681
    • Tennessee
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • SCRI Oncology Partners
        • Contact:
          • David Spigel, Site 0020
          • Phone Number: 615-320-5090
      • Nashville, Tennessee, United States, 37212
        • Not yet recruiting
        • Local Institution - 0697
        • Contact:
          • Site 0697
    • Texas
      • Dallas, Texas, United States, 75246
        • Not yet recruiting
        • Local Institution - 0034
        • Contact:
          • Site 0034
      • Galveston, Texas, United States, 77555
        • Not yet recruiting
        • Local Institution - 0692
        • Contact:
          • Site 0692
      • Laredo, Texas, United States, 78041
        • Not yet recruiting
        • Local Institution - 0652
        • Contact:
          • Site 0652
      • San Antonio, Texas, United States, 78217
        • Recruiting
        • Texas Oncology - San Antonio
        • Contact:
          • Krishna Alluri, Site 0622
          • Phone Number: 210-656-7177
      • Tyler, Texas, United States, 75702
        • Not yet recruiting
        • Local Institution - 0700
        • Contact:
          • Site 0700

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor sample and/or circulating tumor deoxyribonucleic acid (ctDNA).
  • Locally advanced or metastatic disease.
  • Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion.
  • No prior systemic anti-cancer therapy given for advanced or metastatic disease.
  • Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection).
  • Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter.
  • Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx.

Exclusion Criteria:

  • Participants with an active autoimmune or inflammatory disease requiring systemic treatment within 2 years.
  • Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment that are ongoing or with risk of recurrence.
  • Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities.
  • Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry.
  • Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting.
  • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Drug: Placebo
Specified dose on specified days
Drug: Carboplatin
Specified dose on specified days
Drug: Cisplatin
Specified dose on specified days
Drug: Pemetrexed
Specified dose on specified days
Drug: Pembrolizumab
Specified dose on specified days
Other Names:
  • KEYTRUDA®
Experimental: Adagrasib
Drug: Carboplatin
Specified dose on specified days
Drug: Cisplatin
Specified dose on specified days
Drug: Pemetrexed
Specified dose on specified days
Drug: Pembrolizumab
Specified dose on specified days
Other Names:
  • KEYTRUDA®
Drug: Adagrasib
Specified dose on specified days
Other Names:
  • BMS-986503; KRAZATI®

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Overall Survival (OS)
Time Frame: Up to 7 years
Up to 7 years
Progression Free Survival (PFS) as Assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Blinded Independent Central Review (BICR)
Time Frame: Up to 7 years
Up to 7 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Overall Response (OR) as Assessed per RECIST v1.1 by BICR
Time Frame: Up to 7 years
Up to 7 years
Duration of Response (DOR) as Assessed per RECIST 1.1 by BICR
Time Frame: Up to 7 years
Up to 7 years
PFS as Assessed per RECIST v1.1 by Investigator
Time Frame: Up to 7 years
Up to 7 years
Number of Participants With Adverse Events (AEs)
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Number of Participants With Serious Adverse Events (SAEs)
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Number of Participants With AEs Leading to Dose Interruption
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Number of Participants With AEs Leading to Dose Reduction
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Number of Participants With AEs Leading to Treatment Discontinuation
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Number of Deaths
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose
Time to Definitive Deterioration by Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ) Total Score
Time Frame: Up to 7 years
Up to 7 years
Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30) Scale/item Score
Time Frame: Up to 90 days from last dose
Up to 90 days from last dose

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mirati Therapeutics Inc.

Investigators

  • Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 24, 2025

Primary Completion (Estimated)

September 7, 2029

Study Completion (Estimated)

April 30, 2032

Study Registration Dates

First Submitted

March 7, 2025

First Submitted That Met QC Criteria

March 7, 2025

First Posted (Actual)

March 13, 2025

Study Record Updates

Last Update Posted (Actual)

June 2, 2026

Last Update Submitted That Met QC Criteria

June 1, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CA239-0004
  • CA2390004 (Other Identifier: Mirati Therapeutics Protocol ID)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

IPD Sharing Time Frame

See Plan Description

IPD Sharing Access Criteria

See Plan Description

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Carcinoma, Non-Small-Cell Lung

Clinical Trials on Placebo

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Djibouti

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe