Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer (SUNRAY-02)

May 18, 2026 updated by: Eli Lilly and Company

A Phase 3, Multicenter, Double-Blind, Placebo-controlled Study Assessing the Efficacy and Safety of Olomorasib in Combination With Standard of Care Immunotherapy in Participants With Resected or Unresectable KRAS G12C-Mutant, Non-Small Cell Lung Cancer - SUNRAY-02

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

700

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Contact Backup

Study Locations

  • Australia
      • Auchenflower, Australia, 4066
        • Recruiting
        • Icon Cancer Centre Wesley
        • Principal Investigator:
          • Adam Stirling
      • Birtinya, Australia, 4575
        • Recruiting
        • Sunshine Coast University Hospital
        • Principal Investigator:
          • Bryan Chan
        • Contact:
          • Phone Number: 07 5202 0000
      • Heidelberg, Australia, 3084
        • Recruiting
        • Austin Health
        • Principal Investigator:
          • Sagun Parakh
      • Kurralta Park, Australia, 5037
        • Recruiting
        • ICON Cancer Centre - Kurralta Park
        • Principal Investigator:
          • Dainik Patel
        • Contact:
          • Phone Number: 882820833
      • North Tamworth, Australia, 2340
        • Recruiting
        • Tamworth Hospital
        • Principal Investigator:
          • Sunil Rai
      • Perth, Australia, 6009
        • Recruiting
        • Sir Charles Gairdner Hospital
        • Principal Investigator:
          • Samantha Bowyer
      • Shepparton, Australia, 3630
        • Recruiting
        • Goulburn Valley Health
        • Contact:
          • Phone Number: 61358323777
        • Principal Investigator:
          • Myron Klevansky
      • Traralgon, Australia, 3844
        • Recruiting
        • Latrobe Regional Health
        • Principal Investigator:
          • Nguyen Chau
  • Austria
      • Graz, Austria, 8036
        • Recruiting
        • Medizinische Universität Graz
        • Contact:
          • Phone Number: +43 316 38513028
        • Principal Investigator:
          • Gudrun Absenger
      • Linz, Austria, 4020
        • Recruiting
        • Ordensklinikum Linz GmbH Elisabethinen
        • Principal Investigator:
          • Michael Schumacher
      • Vienna, Austria, 1210
        • Recruiting
        • Klinik Floridsdorf
        • Principal Investigator:
          • Maximilian Hochmair
        • Contact:
          • Phone Number: 43 1 27700 2212
  • Belgium
      • Auderghem, Belgium, 1160
        • Recruiting
        • CHIREC - site delta
        • Principal Investigator:
          • Christophe Compère
        • Contact:
          • Phone Number: 0032 2 434 81 13
      • Edegem, Belgium, 2650
        • Recruiting
        • Antwerp University Hospital
        • Principal Investigator:
          • Jo Raskin
        • Contact:
          • Phone Number: 32 3 821 37 25
      • Leuven, Belgium, 3000
        • Recruiting
        • UZ Leuven
        • Principal Investigator:
          • christophe Dooms
        • Contact:
          • Phone Number: 32 16 34 68 02
      • Roeselare, Belgium, 8800
        • Recruiting
        • AZ Delta VZW
        • Principal Investigator:
          • Ingel Demedts
        • Contact:
          • Phone Number: 003251237207
  • Brazil
      • Barretos, Brazil, 14784400
        • Recruiting
        • Fundação Pio XII - Hospital de Câncer de Barretos
        • Contact:
          • Phone Number: 551733216637
        • Principal Investigator:
          • Dayana Mendes Ribeiro
      • Belo Horizonte, Brazil, 30180-060
        • Recruiting
        • Oncocentro de Minas Gerais
        • Principal Investigator:
          • Flavia Duarte
      • Belém, Brazil, 66063-495
        • Recruiting
        • CTO - Centro de Tratamento Oncológico
        • Contact:
          • Phone Number: 5591999809897
        • Principal Investigator:
          • Bruno Fernandes
      • Bento Gonçalves, Brazil, 95700-084
        • Recruiting
        • Hospital Tacchini
        • Principal Investigator:
          • ANDRE REIRIZ
      • Campinas, Brazil, 13060-803
        • Recruiting
        • Centro de Pesquisa Sao Lucas
        • Principal Investigator:
          • Andre Sasse
      • Fortaleza, Brazil, 60430235
        • Recruiting
        • Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
        • Contact:
          • Phone Number: 558532884576
        • Principal Investigator:
          • Fabio Chaves
      • Londrina, Brazil, 86015-520
        • Recruiting
        • Hospital de Cancer de Londrina
        • Contact:
          • Phone Number: 55 41 996379769
        • Principal Investigator:
          • Mariana Piovesana
      • Natal, Brazil, 59075-740
        • Recruiting
        • Liga Norte Riograndense Contra o Cancer
        • Principal Investigator:
          • Sulene Oliveira
        • Contact:
          • Phone Number: 55 84 40095595
      • Porto Alegre, Brazil, 90610-000
        • Recruiting
        • Hospital Sao Lucas Da Pucrs
        • Principal Investigator:
          • Ana Caroline Gelatti
      • Rio de Janeiro, Brazil, 22250-905
        • Recruiting
        • Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
        • Principal Investigator:
          • Tatiane Montella
      • Rio de Janeiro, Brazil, 22271-110
        • Recruiting
        • Instituto D'Or Pesquisa e Ensino
        • Principal Investigator:
          • Clarissa Serodio da Rocha Baldotto
      • São Paulo, Brazil, 04543-000
        • Recruiting
        • Instituto D'Or de Pesquisa e Ensino (IDOR)
        • Principal Investigator:
          • Milena Perez Mak
      • São Paulo, Brazil, 01246-000
        • Recruiting
        • ICESP - Instituto do Cancer do Estado de Sao Paulo
        • Principal Investigator:
          • Gilberto Castro
        • Contact:
          • Phone Number: 5511999685217
      • São Paulo, Brazil, 01452-000
        • Recruiting
        • Centro Paulista de Oncologia Clínica
        • Principal Investigator:
          • William Nassib William Junior
        • Contact:
          • Phone Number: 551135056616
      • São Paulo, Brazil, 01310-000
        • Recruiting
        • Hospital Santa Catarina - Paulista
        • Principal Investigator:
          • Gregorio Soares
      • São Paulo, Brazil, 01308-060
        • Recruiting
        • Hospital Sirio Libanes
        • Principal Investigator:
          • Guilherme Harada
  • Chile
      • Providencia, Chile, 7510254
        • Not yet recruiting
        • K2 Oncology
        • Contact:
          • Phone Number: 56 9 61157903
        • Principal Investigator:
          • pablo Rodriguez Monarca
      • Santiago, Chile, 7500921
        • Not yet recruiting
        • FALP
        • Principal Investigator:
          • Rodrigo Uribe
      • Santiago, Chile, 7560908
        • Not yet recruiting
        • Centro de Oncologia de Precision
        • Principal Investigator:
          • Pamela Salman
      • Santiago, Chile, 8420383
        • Not yet recruiting
        • Bradfordhill
        • Principal Investigator:
          • Carlos Rojas
  • China
      • Anyang, China, 455000
        • Recruiting
        • Anyang Cancer Hospital
        • Principal Investigator:
          • Yaowen Zhang
      • Beijing, China, 100142
        • Recruiting
        • Beijing Cancer Hospital
        • Principal Investigator:
          • Shi Yan
      • Beijing, China, 100029
        • Recruiting
        • China-Japan Friendship Hospital
        • Principal Investigator:
          • Guangying Zhu
        • Contact:
          • Phone Number: 13611108002
      • Beijing, China, 100021
        • Recruiting
        • Cancer Hospital Chinese Academy of Medical Science
        • Principal Investigator:
          • Nan Bi
      • Beijing, China, 100034
        • Recruiting
        • Peking University People's Hospital
        • Principal Investigator:
          • Fan Yang
      • Changchun, China, 132000
        • Recruiting
        • Jilin Cancer Hospital
        • Principal Investigator:
          • Haifeng Liu
      • Changsha, China, 410013
        • Recruiting
        • Hunan Cancer Hospital
        • Principal Investigator:
          • Lin Wu
      • Changsha, China, 410008
        • Recruiting
        • Xiangya Hospital Central South University
        • Principal Investigator:
          • Yang Gao
      • Chengdu, China, 610041
        • Recruiting
        • West China Hospital, Sichuan University
        • Principal Investigator:
          • Qinghua Zhou
      • Chengdu, China, 610041
        • Recruiting
        • Sichuan Cancer Hospital
        • Principal Investigator:
          • Wenxiu Yao
      • Chengdu, China, 610031
        • Recruiting
        • The Third People's Hospital of Chengdu (CDTPH)
        • Principal Investigator:
          • Zhumei Luo
      • Chongqing, China, 400072
        • Recruiting
        • The Second Affiliated Hospital Chongqing Medical University
        • Contact:
          • Phone Number: 13452414579
        • Principal Investigator:
          • Na Li
      • Foshan, China, 528041
        • Recruiting
        • The First People's Hospital of Foshan
        • Principal Investigator:
          • Weineng Feng
      • Guangzhou, China, 510120
        • Recruiting
        • Guangdong Provincial People's Hospital
        • Principal Investigator:
          • Wenzhao Zhong
      • Guangzhou, China
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University
        • Principal Investigator:
          • Jiancong Sun
      • Hangzhou, China, 310014
        • Recruiting
        • Zhejiang provincial people's hospital
        • Principal Investigator:
          • Liu Yang
      • Hangzhou, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital
        • Principal Investigator:
          • jian zeng
      • Hangzhou, China, 310052
        • Recruiting
        • The Second Affiliated Hospital of Zhejiang University School of Medicine
        • Principal Investigator:
          • Junqiang Fan
      • Harbin, China, 150081
        • Recruiting
        • Harbin Medical University Cancer Hospital
        • Contact:
          • Phone Number: 13904505825
        • Principal Investigator:
          • Yan Yu
      • Jinan, China, 250117
        • Recruiting
        • Shandong Cancer Hospital
        • Principal Investigator:
          • Linlin Wang
      • Jinan, China, 250013
        • Recruiting
        • Jinan Central Hospital
        • Principal Investigator:
          • Meili Sun
      • Linhai, China, 317000
        • Recruiting
        • Taizhou Hospital of Zhejiang Province
        • Principal Investigator:
          • Dongqing LV
      • Liuzhou, China, 545006
        • Recruiting
        • Liuzhou People's Hospital
        • Principal Investigator:
          • Xuejun Qin
      • Luoyang, China, 471003
        • Recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Principal Investigator:
          • Zhiye Zhang
      • Nanning, China, 530021
        • Recruiting
        • Guangxi Medical University Affiliated Tumor Hospital
        • Principal Investigator:
          • Jiangqiong Huang
      • Neijiang, China, 641000
        • Recruiting
        • The Second People's Hospital of Neijiang
        • Principal Investigator:
          • Yu Liu
      • Shanghai, China, 200032
        • Recruiting
        • Fudan University Shanghai Cancer Center
        • Principal Investigator:
          • MIN FAN
      • Shanghai, China, 200030
        • Recruiting
        • Shanghai Chest Hospital
        • Principal Investigator:
          • Hua Zhong
        • Contact:
          • Phone Number: 13818200560
      • Shantou, China, 515000
        • Recruiting
        • Cancer Hospital of Shantou University Medical College
        • Principal Investigator:
          • Fangcai Wu
      • Shenzhen, China, 518020
        • Recruiting
        • Shenzhen People's Hospital
        • Principal Investigator:
          • Lin Yang
      • Shenzhen, China, 518127
        • Recruiting
        • Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
        • Principal Investigator:
          • Jun Liang
      • Suzhou, China, 215006
        • Recruiting
        • The First Affiliated Hospital of Soochow University
        • Principal Investigator:
          • Chuanyong Mu
      • Tianjin, China, 300060
        • Recruiting
        • Tianjin Medical University Cancer Institute & Hospital
        • Principal Investigator:
          • Zhenfa Zhang
      • Tianjin, China
        • Recruiting
        • Tianjin Medical University Cancer Institute & Hospital
        • Principal Investigator:
          • Qingsong Pang
      • Wuhan, China, 430079
        • Recruiting
        • Hubei Cancer Hospital
        • Principal Investigator:
          • Guang Han
      • Wuhan, China, 430030
        • Recruiting
        • Tongji Hospital Tongji Medical,Science & Technology
        • Principal Investigator:
          • Qian Chu
      • Xi'an, China, 710061
        • Recruiting
        • The First Affiliated Hospital of Xi'an Jiaotong University
        • Principal Investigator:
          • Yu Yao
      • Zhongshan, China, 528403
        • Recruiting
        • Zhongshan Peoples Hospital
        • Principal Investigator:
          • Minying Li
      • Zhuzhou, China, 412007
        • Recruiting
        • Zhuzhou Central Hospital
        • Principal Investigator:
          • Yanchao Liang
  • Czechia
      • Ostrava, Czechia, 703 00
        • Recruiting
        • Nemocnice AGEL Ostrava - Vitkovice a.s.
        • Principal Investigator:
          • Jaromir Roubec
      • Prague, Czechia, 180 81
        • Recruiting
        • Fakultni Nemocnice Bulovka
        • Principal Investigator:
          • Jana Krejci
        • Contact:
          • Phone Number: 420607533688
  • France
      • Bron, France, 69677
        • Recruiting
        • Hospices Civils de Lyon - Hôpital Louis Pradel
        • Principal Investigator:
          • Michael Duruisseaux
      • La Tronche, France, 38700
        • Recruiting
        • Chu Grenoble Alpes
        • Principal Investigator:
          • Denis Moro-Sibilot
        • Contact:
          • Phone Number: 33476766453
      • Lyon Cedex08, France, 69373
        • Recruiting
        • Centre Leon Berard
        • Principal Investigator:
          • Maurice Perol
        • Contact:
          • Phone Number: 33426556761
      • Marseille, France, 13915
        • Recruiting
        • Assistance Publique Hôpitaux de Marseille - Hôpital Nord
        • Principal Investigator:
          • Pascale Tomasini
        • Contact:
          • Phone Number: +33491384644
      • Nice, France, 06189
        • Recruiting
        • Centre Antoine-Lacassagne
        • Principal Investigator:
          • Victoria ferrari
        • Contact:
          • Phone Number: 0492031324
      • Paris, France, 75014
        • Recruiting
        • Groupe hospitalier Paris saint Joseph
        • Principal Investigator:
          • Charles Naltet
      • Paris, France, 75015
        • Recruiting
        • Hôpital Europeen Georges Pompidou
        • Contact:
          • Phone Number: 00 33 1 56 09 34 74
        • Principal Investigator:
          • Elizabeth Fabre
      • Paris, France, 75248
        • Recruiting
        • Institut Curie
        • Principal Investigator:
          • nicolas girard
        • Contact:
          • Phone Number: 33624456290
      • Pessac, France, 33600
        • Recruiting
        • CHU Bordeaux Haut-Leveque
        • Principal Investigator:
          • MAEVA ZYSMAN
      • Poitiers, France, 86021
        • Not yet recruiting
        • Centre Hospitalier Universitaire de Poitiers
        • Principal Investigator:
          • Clotilde Deldycke
      • Reims, France, 51726
        • Recruiting
        • Institut Jean Godinot
        • Principal Investigator:
          • Amélie Lemoine
      • Rennes, France, 35033
        • Recruiting
        • Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
        • Principal Investigator:
          • Yannick Le Guen
      • Saint-Herblain, France, 44805
        • Not yet recruiting
        • Institut de Cancérologie de l'Ouest
        • Principal Investigator:
          • Ludovic Doucet
        • Contact:
          • Phone Number: 33240679899
      • Toulouse, France, 31059
        • Recruiting
        • CHU de Toulouse - Hopital Larrey
        • Principal Investigator:
          • Julien Mazieres
        • Contact:
          • Phone Number: 335677718
      • Vantoux, France, 57070
        • Recruiting
        • Hopital Robert Schuman
        • Principal Investigator:
          • Lucile ROUSSEL
      • Villejuif, France, 94800
        • Recruiting
        • Gustave Roussy
        • Principal Investigator:
          • Fabrice Barlesi
  • Germany
      • Berlin, Germany, 13125
        • Recruiting
        • Evangelische Lungenklinik Berlin
        • Principal Investigator:
          • Christian Grohe
      • Berlin, Germany, 13353
        • Not yet recruiting
        • Charité Campus Virchow-Klinikum
        • Principal Investigator:
          • Nikolaj Frost
        • Contact:
          • Phone Number: 004930450553044
      • Berlin, Germany, 13359
        • Recruiting
        • DRK Kliniken Berlin Mitte
        • Principal Investigator:
          • Bernd Schmidt
        • Contact:
          • Phone Number: +493030356297
      • Berlin, Germany, 10249
        • Recruiting
        • Vivantes Klinikum im Friedrichshain - Landsberger Allee
        • Principal Investigator:
          • Peter Thuss-Patience
        • Contact:
          • Phone Number: 49 151 53854841
      • Chemnitz, Germany, 09116
        • Recruiting
        • Klinikum Chemnitz
        • Principal Investigator:
          • Stefan Hammerschmidt
        • Contact:
          • Phone Number: 4937133343550
      • Cologne, Germany, 50677
        • Recruiting
        • MV-Zentrum für Onkologie und Hämatologie
        • Principal Investigator:
          • Jan-Phillip Weber
      • Donauwörth, Germany, 86609
        • Recruiting
        • Onkologiezentrum Donauwörth
        • Principal Investigator:
          • Bastian Fleischmann
        • Contact:
          • Phone Number: 49990629993911
      • Erfurt, Germany, 99089
        • Recruiting
        • Helios Klinikum Erfurt
        • Principal Investigator:
          • Eva-Maria Barkowsky
        • Contact:
          • Phone Number: 03617812586
      • Gauting, Germany, 82131
        • Recruiting
        • Asklepios Fachkliniken München-Gauting
        • Principal Investigator:
          • Niels Reinmuth
        • Contact:
          • Phone Number: 004989857914001
      • Georgsmarienhütte, Germany, 49124
        • Recruiting
        • Franziskus-Hospital Harderberg
        • Principal Investigator:
          • Petra Hoffknecht
      • Großhansdorf, Germany, 22927
        • Recruiting
        • LungenClinic Grosshansdorf
        • Principal Investigator:
          • Martin Reck
      • Halle, Germany, 06120
        • Recruiting
        • Krankenhaus Martha-Maria Halle-Dölau
        • Principal Investigator:
          • Miriam Moeller
      • Hamburg, Germany, 21075
        • Recruiting
        • Asklepios Klinik Harburg
        • Principal Investigator:
          • Claas Wesseler
      • Heidelberg, Germany, 69126
        • Not yet recruiting
        • Thoraxklinik-Heidelberg gGmbH
        • Principal Investigator:
          • Helge Bischoff
        • Contact:
          • Phone Number: 49 6221 3968304
      • Herne, Germany, 44651
        • Not yet recruiting
        • Evangelisches Krankenhaus Herne - Eickel
        • Principal Investigator:
          • Daniel Christoph
        • Contact:
          • Phone Number: +4920117424015
      • Leipzig, Germany, 04277
        • Recruiting
        • St. Elisabeth-Krankenhaus Leipzig
        • Contact:
          • Phone Number: + 49 34139597302
        • Principal Investigator:
          • Sylvia Gütz
      • Nuremberg, Germany, 90419
        • Recruiting
        • Klinikum Nürnberg Nord
        • Contact:
          • Phone Number: 0911398114963
        • Principal Investigator:
          • Markus Horneber
      • Stuttgart, Germany, 70376
        • Recruiting
        • Robert Bosch Krankenhaus GmbH
        • Principal Investigator:
          • Hans-Georg Kopp
        • Contact:
          • Phone Number: +4971181016266
      • Tübingen, Germany, 72076
        • Recruiting
        • Universitaetsklinikum Tuebingen
        • Contact:
          • Phone Number: 4970712982711
        • Principal Investigator:
          • Thorben Gross
  • Greece
      • Athens, Greece, 115 27
        • Not yet recruiting
        • Thoracic General Hospital of Athens "I Sotiria"
        • Principal Investigator:
          • Konstantinos Syrigos
        • Contact:
          • Phone Number: 302107700220
      • Athens, Greece, 115 22
        • Recruiting
        • Agios Savvas Regional Cancer Hospital
        • Principal Investigator:
          • ANASTASIOS GRIVAS
      • Athens, Greece, 115 26
        • Recruiting
        • Errikos Dunant Hospital Center
        • Principal Investigator:
          • Ioannis Mountzios
      • Heraklion, Greece, 715 00
        • Recruiting
        • University General Hospital of Heraklion
        • Contact:
          • Phone Number: 302810392438
        • Principal Investigator:
          • Sofia Agelaki
      • Larissa, Greece, 41110
        • Recruiting
        • University General Hospital of Larissa
        • Principal Investigator:
          • Athanasios Kotsakis
        • Contact:
          • Phone Number: 302413502785
      • Pátrai, Greece, 26504
        • Recruiting
        • University Hospital of Patras
        • Contact:
          • Phone Number: 302610999791
        • Principal Investigator:
          • Angelos Koutras
      • Thessaloniki, Greece, 570 01
        • Not yet recruiting
        • European Interbalkan Medical Center
        • Principal Investigator:
          • Sofia Baka
      • Thessaloniki, Greece, 552 36
        • Recruiting
        • Agios Loukas Clinic
        • Contact:
          • Phone Number: 2310390972
        • Principal Investigator:
          • Elena Fountzila
  • Hungary
      • Budapest, Hungary, 1122
        • Not yet recruiting
        • Országos Onkológiai Intézet
        • Principal Investigator:
          • Tunde Nagy
      • Budapest, Hungary, 1145
        • Recruiting
        • Budapesti Uzsoki Utcai Korhaz
        • Principal Investigator:
          • Csaba Mathe
        • Contact:
          • Phone Number: +3614673852
      • Farkasgyepű, Hungary, 8582
        • Recruiting
        • Farkasgyepui Tudogyogyintezet
        • Principal Investigator:
          • Zsolt Király
  • India
      • Ahmedabad, India, 380054
        • Recruiting
        • Hemato Oncology Clinic
        • Principal Investigator:
          • Chirag Desai
        • Contact:
          • Phone Number: 09824047561
      • Aurangabad, India, 431001
        • Recruiting
        • Galaxy Superspeciality Hospital
        • Principal Investigator:
          • Ketan Shirsath
      • Chennai, India, 600003
        • Recruiting
        • Rajiv Gandhi Government General Hospital
        • Principal Investigator:
          • Kannan Jayaraman
      • Mumbai, India, 400004
        • Recruiting
        • Sir H. N. Reliance Foundation Hospital and Research Centre
        • Contact:
          • Phone Number: +91 9619607339
        • Principal Investigator:
          • Sewanti Limaye
      • Namakkal, India, 637001
        • Recruiting
        • Thangam Cancer Center - Namakkal
        • Principal Investigator:
          • Bhavesh Poladia
      • Patna, India, 800020
        • Recruiting
        • Savera Cancer & Multi Speciality Hospital
        • Principal Investigator:
          • Avinash Pandey
        • Contact:
          • Phone Number: 9967673497
      • Pune, India, 411004
        • Recruiting
        • Deenanath Mangeshkar Hospital & Research Centre
        • Contact:
          • Phone Number: 91-20-4915-2434
        • Principal Investigator:
          • Chetan Deshmukh
      • Pune, India, 411007
        • Recruiting
        • Medipoint Hospitals Pvt. Ltd.
        • Principal Investigator:
          • Rahul Kulkarni
      • Thalassery, India, 670103
        • Recruiting
        • Malabar Cancer Centre - Thalassery
        • Contact:
          • Phone Number: 91 4902399250
        • Principal Investigator:
          • Nandini R
      • Thiruvananthapuram, India, 695011
        • Recruiting
        • Regional Cancer Centre - Thiruvananthapuram
        • Principal Investigator:
          • Anoop Manoharan
      • Udaipur, India, 313001
        • Recruiting
        • Pacific Medical College & Hospital
        • Principal Investigator:
          • Manoj Mahajan
      • Varanasi, India, 221002
        • Recruiting
        • Tata Memorial Centre - Homi Bhabha Cancer Hospital
        • Contact:
          • Phone Number: 8002583913
        • Principal Investigator:
          • Bipinesh Sansar
  • Israel
      • Haifa, Israel, 3109601
        • Recruiting
        • Rambam Health Care Campus
        • Contact:
          • Phone Number: 97247776700
        • Principal Investigator:
          • Alona Zer Kuch
      • Jerusalem, Israel, 9013102
        • Recruiting
        • Shaare Zedek Medical Center
        • Principal Investigator:
          • Nir Peled
        • Contact:
          • Phone Number: 97226555361
      • Kfar Saba, Israel, 4428164
        • Recruiting
        • Meir Medical Center
        • Contact:
          • Phone Number: 972-9-7472414
        • Principal Investigator:
          • Maya Gottfried
      • Ramat Gan, Israel, 5265601
        • Recruiting
        • Sheba Medical Center
        • Contact:
          • Phone Number: 97235307096
        • Principal Investigator:
          • Jair Bar
  • Italy
      • Bari, Italy, 70124
        • Recruiting
        • Instituto Tumori Giovanni Paolo II
        • Principal Investigator:
          • Domenico Galetta
        • Contact:
          • Phone Number: 39 080 5555442
      • Catania, Italy, 95123
        • Recruiting
        • Policlinico "G. Rodolico"
        • Principal Investigator:
          • HECTOR SOTO PARRA
        • Contact:
          • Phone Number: 390953781496
      • Genova, Italy, 16132
        • Recruiting
        • Ospedale San Martino
        • Principal Investigator:
          • Carlo Genova
        • Contact:
          • Phone Number: 0105558918
      • Meldola, Italy, 47014
        • Recruiting
        • Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori
        • Contact:
          • Phone Number: 390543739100
        • Principal Investigator:
          • Angelo Delmonte
      • Milan, Italy, 20162
        • Recruiting
        • ASST Grande Ospedale Metropolitano Niguarda
        • Principal Investigator:
          • Diego Signorelli
        • Contact:
          • Phone Number: 390264442291
      • Monza, Italy, 20900
        • Recruiting
        • Ospedale San Gerardo-ASST Monza
        • Principal Investigator:
          • Diego Cortinovis
        • Contact:
          • Phone Number: 390392336040
      • Naples, Italy, 80131
        • Recruiting
        • Azienda Ospedaliera dei Colli
        • Principal Investigator:
          • Danilo Rocco
        • Contact:
          • Phone Number: 393356489706
      • Orbassano, Italy, 10043
        • Recruiting
        • Azienda Sanitaria Ospedaliera S Luigi Gonzaga
        • Principal Investigator:
          • Silvia Novello
        • Contact:
          • Phone Number: 390119026233
      • Rome, Italy, 00144
        • Recruiting
        • Istituto Nazionale Tumori Regina Elena
        • Principal Investigator:
          • Lorenza Landi
      • Verona, Italy, 37126
        • Recruiting
        • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
        • Contact:
          • Phone Number: 3904518123515
        • Principal Investigator:
          • SARA PILOTTO
  • Japan
      • Bunkyō City, Japan, 113-8431
        • Recruiting
        • Juntendo University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takehito Shukuya
      • Bunkyō City, Japan, 113-8677
        • Recruiting
        • Tokyo Metropolitan Komagome Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kageaki Watanabe
      • Fukuoka, Japan, 812-8582
        • Recruiting
        • Kyushu University Hospital
        • Principal Investigator:
          • Isamu Okamoto
        • Contact:
          • Phone Number: 81120023812
      • Hidaka, Japan, 350-1298
        • Recruiting
        • Saitama Medical University International Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Atsuto Mouri
      • Himeji, Japan, 670-8520
        • Recruiting
        • Himeji Medical Center
        • Principal Investigator:
          • Tetsuji Kawamura
        • Contact:
          • Phone Number: 81120023812
      • Hirakata, Japan, 573-1191
        • Recruiting
        • Kansai Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takayasu Kurata
      • Kanazawa, Japan, 920-8641
        • Recruiting
        • Kanazawa University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shinji Takeuchi
      • Kashiwa, Japan, 277-8577
        • Recruiting
        • National Cancer Center Hospital East
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Keiju Aokage
      • Kyoto, Japan, 602-8566
        • Recruiting
        • University Hospital,Kyoto Prefectural University of Medicine
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tadaaki Yamada
      • Kōtō City, Japan, 135-8550
        • Recruiting
        • The Cancer Institute Hospital Of JFCR
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Ryo Ariyasu
      • Nagaizumi-cho,Sunto-gun, Japan, 411-8777
        • Recruiting
        • Shizuoka Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Akira Ono
      • Nagoya, Japan, 464-8681
        • Recruiting
        • Aichi Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yutaka Fujiwara
      • Natori, Japan, 981-1293
        • Recruiting
        • Miyagi Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tatsuro Fukuhara
      • Niigata, Japan, 951-8566
        • Recruiting
        • Niigata Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroshi Tanaka
      • Sakai, Japan, 590-0197
        • Recruiting
        • Kindai University Hospital- Osakasayama Campus
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hidetoshi Hayashi
      • Sakai, Japan, 591-8555
        • Recruiting
        • NHO Kinki Chuo Chest Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kyoichi Okishio
      • Sapporo, Japan, 060-8648
        • Recruiting
        • Hokkaido University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Jun Sakakibara
      • Wakayama, Japan, 641-8510
        • Recruiting
        • Wakayama Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yuhei Harutani
      • Yokohama, Japan, 236-0051
        • Recruiting
        • Kanagawa Cardiovascular and Respiratory Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Akimasa Sekine
      • Yokohama, Japan, 2418515
        • Recruiting
        • Kanagawa Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Seigo Katakura
      • Yonago, Japan, 683-8504
        • Recruiting
        • Tottori University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tomohiro Sakamoto
  • Netherlands
      • Amsterdam, Netherlands, 1081 HV
        • Recruiting
        • Amsterdam UMC, Locatie VUMC
        • Contact:
          • Phone Number: 31204444782
        • Principal Investigator:
          • I Bahce
      • Amsterdam, Netherlands, 1066 CX
        • Not yet recruiting
        • Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)
        • Contact:
          • Phone Number: 31205129111
        • Principal Investigator:
          • Adrianus de Langen
      • Breda, Netherlands, 4818 CK
        • Recruiting
        • Amphia Ziekenhuis, locatie Breda Molengracht
        • Contact:
          • Phone Number: 00310765953121
        • Principal Investigator:
          • Kornelis van der Leest
      • Harderwijk, Netherlands, 3844 DG
        • Recruiting
        • Ziekenhuis St. Jansdal
        • Principal Investigator:
          • L.N. Boom
        • Contact:
          • Phone Number: 0031 341 463504
      • Tilburg, Netherlands, 5022 GC
        • Recruiting
        • ETZ Elisabeth
        • Contact:
          • Phone Number: 31132213101
        • Principal Investigator:
          • Mart Schiefer
      • Utrecht, Netherlands, 3543 AZ
        • Recruiting
        • St. Antonius Ziekenhuis, locatie Utrecht
        • Contact:
          • Phone Number: 31883201410
        • Principal Investigator:
          • Lisanne Kastelijn
      • Zwolle, Netherlands, 8025 AB
        • Recruiting
        • Isala, locatie Zwolle
        • Contact:
          • Phone Number: 31886243254
        • Principal Investigator:
          • Peter Plomp
  • Norway
      • Arendal, Norway, 4838
        • Recruiting
        • Sorlandet Sykehus Arendal
        • Principal Investigator:
          • Karina Vintermyr
      • Bergen, Norway, 5021
        • Recruiting
        • Haukeland Universitetssjukehus
        • Contact:
          • Phone Number: 4755973245
        • Principal Investigator:
          • Oystein Flotten
      • Drammen, Norway, 3004
        • Recruiting
        • Drammen Sykehus, Vestre Viken HF
        • Principal Investigator:
          • Inger Johanne Eide
      • Gjøvik, Norway, 2819
        • Recruiting
        • Sykehuset Innlandet HF Gjøvik
        • Principal Investigator:
          • Daniel Heinrich
        • Contact:
          • Phone Number: 4791395554
      • Oslo, Norway, 0379
        • Recruiting
        • Oslo universitetssykehus, Radiumhospitalet
        • Contact:
          • Phone Number: 47 02770
        • Principal Investigator:
          • Vilde Haakensen
  • Poland
      • Kielce, Poland, 25-734
        • Recruiting
        • Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej
        • Principal Investigator:
          • Kinga Szydziak-Zwierzynska
        • Contact:
          • Phone Number: 48 41 3674809
      • Poznan, Poland, 60-569
        • Recruiting
        • Wielkopolskie Centrum Pulmonologii i Torakochirurgii
        • Principal Investigator:
          • Katarzyna Stencel
        • Contact:
          • Phone Number: 616654242
      • Szczecin, Poland, 70-419
        • Recruiting
        • One Day Med
        • Principal Investigator:
          • Piotr Serwatowski
        • Contact:
          • Phone Number: 48914427209
  • Portugal
      • Coimbra, Portugal, 3040
        • Recruiting
        • Centro Hospitalar e Universitario de Coimbra
        • Principal Investigator:
          • Ana Figueiredo
      • Lisbon, Portugal, 1500-650
        • Recruiting
        • Hospital da Luz Lisboa
        • Principal Investigator:
          • Joao Moreira Pinto
      • Porto, Portugal, 4200-072
        • Recruiting
        • Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
        • Principal Investigator:
          • Marta Soares
      • Porto, Portugal, 4100-180
        • Recruiting
        • Hospital CUF Porto
        • Contact:
          • Phone Number: 220039029
        • Principal Investigator:
          • Venceslau Hespanhol
  • Romania
      • Bucharest, Romania, 012292
        • Recruiting
        • Lotus-Med
        • Principal Investigator:
          • Ioana Luca
      • Bucharest, Romania, 013812
        • Recruiting
        • SC Memorial Healthcare International SRL
        • Contact:
          • Phone Number: 40721298677
        • Principal Investigator:
          • Ingrid Iordan
      • Cluj-Napoca, Romania, 400015
        • Recruiting
        • Institutul Oncologic
        • Principal Investigator:
          • Tudor Ciuleanu
      • Ovidiu, Romania, 905900
        • Recruiting
        • Ovidius Clinical Hospital OCH
        • Contact:
          • Phone Number: 0724877013
        • Principal Investigator:
          • Laura Mazilu
  • Slovakia
      • Banská Bystrica, Slovakia, 97517
        • Recruiting
        • Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
        • Contact:
          • Phone Number: 00421915831411
        • Principal Investigator:
          • Michal Urda
      • Bratislava, Slovakia, 821 01
        • Recruiting
        • Univerzitná nemocnica Bratislava - Nemocnica Ružinov
        • Contact:
          • Phone Number: 00421903752376
        • Principal Investigator:
          • Zuzana Svihelova Liskova
      • Košice, Slovakia, 041 91
        • Recruiting
        • Vychodoslovensky Onkologicky ustav a.s.
        • Contact:
          • Phone Number: 421556135429
        • Principal Investigator:
          • Jana Jankurova
  • South Korea
      • Bupyeong-gu, South Korea, 21431
        • Recruiting
        • The Catholic University of Korea, Incheon St. Mary's Hospital
        • Principal Investigator:
          • Ju Sang Kim
        • Contact:
          • Phone Number: 01092747783
      • Busan, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital
        • Principal Investigator:
          • Mi-Hyun Kim
      • Cheongju-si, South Korea, 28644
        • Recruiting
        • Chungbuk National University Hospital
        • Principal Investigator:
          • Ki Hyeong Lee
      • Daegu, South Korea, 42601
        • Recruiting
        • Keimyung University Dongsan Hospital
        • Principal Investigator:
          • Sun Hyo Park
        • Contact:
          • Phone Number: 01063522096
      • Deagu, South Korea, 41404
        • Recruiting
        • Kyungpook National University Chilgok Hospital
        • Principal Investigator:
          • Shin Yup Lee
      • Eunpyeong-gu, South Korea, 03312
        • Recruiting
        • The Catholic University of Korea, Eunpyeong St. Mary's Hospital
        • Contact:
          • Phone Number: 82-2-2030-4340
        • Principal Investigator:
          • Chang Dong Yeo
      • Gangnam-gu, South Korea, 06273
        • Recruiting
        • Gangnam Severance Hospital, Yonsei University Health System
        • Contact:
          • Phone Number: 821041821095
        • Principal Investigator:
          • Chi Young Kim
      • Goyang-si, South Korea, 10408
        • Recruiting
        • National Cancer Center
        • Contact:
          • Phone Number: 82319201154
        • Principal Investigator:
          • Ji-Youn Han
      • Hwasun-gun, South Korea, 58128
        • Recruiting
        • Chonnam National University Hwasun Hospital
        • Principal Investigator:
          • Young-Chul Kim
      • Nam-gu, South Korea, 42415
        • Recruiting
        • Yeungnam Univeristy Medical Center
        • Principal Investigator:
          • June Hong Ahn
      • Seongnam, South Korea, 13620
        • Recruiting
        • Seoul National University Bundang Hospital
        • Principal Investigator:
          • Se Hyun Kim
      • Seoul, South Korea, 05505
        • Recruiting
        • Asan Medical Center
        • Principal Investigator:
          • Chang Min Choi
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Principal Investigator:
          • Hye Ryun Kim
        • Contact:
          • Phone Number: 82222284190
      • Seoul, South Korea, 05030
        • Recruiting
        • Konkuk University Medical Center
        • Contact:
          • Phone Number: 01035438353
        • Principal Investigator:
          • In Ae Kim
      • Seoul, South Korea, 06351
        • Recruiting
        • Samsung Medical Center
        • Principal Investigator:
          • Se-Hoon Lee
      • Seoul, South Korea, 06591
        • Recruiting
        • The Catholic Univ. of Korea Seoul St. Mary's Hospital
        • Principal Investigator:
          • SookHee Hong
        • Contact:
          • Phone Number: 82222586045
      • Seoul, South Korea, 07345
        • Recruiting
        • The Catholic University of Korea, Yeouido St. Mary's Hospital
        • Principal Investigator:
          • Chankwon Park
      • Seoul, South Korea, 08308
        • Recruiting
        • Korea University Guro Hospital
        • Principal Investigator:
          • Sung Yong Lee
      • Suwon, South Korea, 16247
        • Recruiting
        • The Catholic University of Korea St. Vincent's Hospital
        • Principal Investigator:
          • Byoung Yong Shim
        • Contact:
          • Phone Number: 82-31-881-8906
      • Yangsan, South Korea, 50612
        • Recruiting
        • Pusan National University Yangsan Hospital
        • Principal Investigator:
          • Seong Hoon Yoon
  • Spain
      • Badajoz, Spain, 06006
        • Recruiting
        • Hospital Infanta Cristina
        • Principal Investigator:
          • Marta González Cordero
        • Contact:
          • Phone Number: 924218040
      • Barcelona, Spain, 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebrón
        • Principal Investigator:
          • Alex Martinez Marti
      • Barcelona, Spain, 08036
        • Recruiting
        • Hospital Clinic De Barcelona
        • Principal Investigator:
          • Laura Mezquita Perez
      • Barcelona, Spain, 08003
        • Recruiting
        • Parc de Salut Mar - Hospital del Mar
        • Principal Investigator:
          • Edurne Arriola Aperribay
        • Contact:
          • Phone Number: 34932483137
      • Hospitalet, Spain, 08907
        • Recruiting
        • Instituto Catalan de Oncologia - Hospital Duran I Reynals
        • Principal Investigator:
          • Ernest Nadal Alforja
        • Contact:
          • Phone Number: 932607744
      • Jerez de la Frontera, Spain, 11407
        • Recruiting
        • Hospital Jerez de la Frontera
        • Principal Investigator:
          • Jesus Corral Jaime
      • Las Palmas de Gran Canaria, Spain, 35016
        • Recruiting
        • Hospital Insular de Gran Canaria
        • Principal Investigator:
          • DELVYS RODRIGUEZ ABREU
        • Contact:
          • Phone Number: 34928441738
      • Madrid, Spain, 28034
        • Recruiting
        • Hospital Universitario Ramon y Cajal
        • Principal Investigator:
          • Pilar Garrido Lopez
        • Contact:
          • Phone Number: (+34) 913368263
      • Madrid, Spain, 28041
        • Recruiting
        • Hospital Universitario 12 De Octubre
        • Principal Investigator:
          • Luis Paz-Ares Rodriguez
        • Contact:
          • Phone Number: 0034913908000
      • Madrid, Spain, 28009
        • Recruiting
        • Hospital General Universitario Gregorio Marañón
        • Principal Investigator:
          • Antonio Calles Blanco
        • Contact:
          • Phone Number: +34915737985
      • Málaga, Spain, 29011
        • Recruiting
        • H.R.U Málaga - Hospital General
        • Contact:
          • Phone Number: 34951308130
        • Principal Investigator:
          • María Vanesa Gutierrez Calderon
      • Palma, Spain, 07120
        • Recruiting
        • Hospital Universitari Son Espases
        • Principal Investigator:
          • Aitor Azkarate Martinez
      • Pamplona, Spain, 31009
        • Recruiting
        • Complejo Hospitalario de Navarra
        • Principal Investigator:
          • Maite Martinez Aguillo
      • Pozuelo de Alarcón, Spain, 28223
        • Recruiting
        • Hospital Universitario Quirónsalud Madrid
        • Principal Investigator:
          • Belen Rubio Viqueira
        • Contact:
          • Phone Number: 34914521987
      • Santiago de Compostela, Spain, 15706
        • Recruiting
        • CHUS - Hospital Clinico Universitario
        • Contact:
          • Phone Number: 981950511
        • Principal Investigator:
          • Luis Leon Mateos
      • Seville, Spain, 41013
        • Recruiting
        • Hospital Universitario Virgen del Rocio
        • Contact:
          • Phone Number: 955013068
        • Principal Investigator:
          • Reyes Bernabe Caro
      • Valencia, Spain, 46010
        • Recruiting
        • Hospital Clinico de Valencia
        • Principal Investigator:
          • Amelia Insa Molla
        • Contact:
          • Phone Number: 961973500
      • Zaragoza, Spain, 50009
        • Recruiting
        • Hospital Clinico Universitario Lozano Blesa
        • Principal Investigator:
          • Dolores Isla Casado
        • Contact:
          • Phone Number: +34976765746
  • Sweden
      • Gothenburg, Sweden, 413 45
        • Recruiting
        • Sahlgrenska Universitetssjukhuset
        • Principal Investigator:
          • Kerstin Gunnarsson
  • Switzerland
      • Baden, Switzerland, 5404
        • Recruiting
        • Kantonsspital Baden
        • Principal Investigator:
          • Sacha Rothschild
      • Fribourg, Switzerland, 1708
        • Recruiting
        • HFR Fribourg - Hôpital Cantonal
        • Principal Investigator:
          • Alessandra Curioni-Fontecedro
        • Contact:
          • Phone Number: +41263062010
      • Locarno, Switzerland, 6600
        • Not yet recruiting
        • Kouros Moccia Oncologia
        • Principal Investigator:
          • Michail Kouros
  • Taiwan
      • Changhua County, Taiwan, 50006
        • Recruiting
        • Changhua Christian Hospital
        • Principal Investigator:
          • Sheng-Hao Lin
        • Contact:
          • Phone Number: +886-4-7238595 ext.3934
      • Chiayi City, Taiwan, 622
        • Recruiting
        • Buddhist Dalin Tzu Chi General Hospital
        • Principal Investigator:
          • Chun-Liang Lai
      • Douliu, Taiwan, 640
        • Recruiting
        • National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
        • Principal Investigator:
          • You-Yi Chen
      • Hualien City, Taiwan, 970
        • Recruiting
        • Hualien Tzu Chi Medical Center
        • Principal Investigator:
          • Chih-Bin Lin
      • Kaohsiung City, Taiwan, 807
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Jen-Yu Hung
        • Contact:
          • Phone Number: 88673121101-5651
      • Kaohsiung City, Taiwan, 82445
        • Recruiting
        • E-DA Hospital
        • Principal Investigator:
          • Yu-Feng Wei
        • Contact:
          • Phone Number: 0975106137
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Principal Investigator:
          • Chin-Chou Wang
        • Contact:
          • Phone Number: +886-7-7317123 ext. 8199
      • New Taipei City, Taiwan, 220
        • Recruiting
        • Far Eastern Memorial Hospital
        • Principal Investigator:
          • Cheng-Yu Chang
      • New Taipei City, Taiwan, 236
        • Recruiting
        • New Taipei Municipal TuCheng Hospital
        • Principal Investigator:
          • Chiao-En Wu
        • Contact:
          • Phone Number: 0975366098
      • Taichung, Taiwan, 402
        • Recruiting
        • Chung Shan Medical University Hospital
        • Principal Investigator:
          • Gee-Chen Chang
        • Contact:
          • Phone Number: 0424739595
      • Taichung, Taiwan, 407
        • Recruiting
        • Taichung Veterans General Hospital
        • Principal Investigator:
          • Tsung-Ying Yang
        • Contact:
          • Phone Number: 886-23592525(3259)
      • Tainan, Taiwan, 704
        • Recruiting
        • National Cheng Kung University Hospital
        • Principal Investigator:
          • Chien-Chung Lin
      • Tainan, Taiwan, 71004
        • Recruiting
        • Chi Mei Medical Center
        • Principal Investigator:
          • SHU FARN TEY
      • Tainan, Taiwan, 73657
        • Recruiting
        • Chi Mei Hospital - Liouying Branch
        • Principal Investigator:
          • Wen-Tsung Huang
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chia-Chi Lin
        • Contact:
          • Phone Number: 886-2-2312-3456
      • Taipei, Taiwan, 11217
        • Recruiting
        • Taipei Veterans General Hospital
        • Contact:
          • Phone Number: 88628712121
        • Principal Investigator:
          • Hsu-Ching Huang
      • Taipei, Taiwan, 106
        • Recruiting
        • National Taiwan University Cancer Center (NTUCC)
        • Principal Investigator:
          • Chih-Hsin Yang
        • Contact:
          • Phone Number: 886-2-23123456
      • Taoyuan, Taiwan, 333
        • Recruiting
        • Chang Gung Medical Foundation-Linkou Branch
        • Principal Investigator:
          • Cheng-Ta Yang
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01370
        • Recruiting
        • Adana City Hospital
        • Principal Investigator:
          • Timucin Cil
        • Contact:
          • Phone Number: 90538 609 92 02
      • Adana, Turkey (Türkiye), 01250
        • Recruiting
        • Baskent University Dr. Turgut Noyan Research and Training Center
        • Contact:
          • Phone Number: 905353067506
        • Principal Investigator:
          • Ozgur Ozyilkan
      • Adapazarı, Turkey (Türkiye), 54290
        • Recruiting
        • Sakarya University School of Medicine
        • Principal Investigator:
          • Ilhan Hacibekiroglu
        • Contact:
          • Phone Number: +90 5054785576
      • Ankara, Turkey (Türkiye), 06010
        • Recruiting
        • University of Health Sciences,Gulhane School of Medicine
        • Principal Investigator:
          • Ismail Erturk
      • Antalya, Turkey (Türkiye), 07100
        • Recruiting
        • Antalya Egitim ve Arastırma Hastanesi
        • Contact:
          • Phone Number: 905336488217
        • Principal Investigator:
          • Derya KIVRAK SALIM
      • Edirne, Turkey (Türkiye), 22030
        • Recruiting
        • Trakya University
        • Principal Investigator:
          • Bulent Erdogan
        • Contact:
          • Phone Number: 905052137335
      • Gaziantep, Turkey (Türkiye), 27310
        • Recruiting
        • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
        • Contact:
          • Phone Number: 05065118207
        • Principal Investigator:
          • Tulay Kus
      • Istanbul, Turkey (Türkiye), 34295
        • Recruiting
        • İ.A.Ü VM Medical Park Florya Hastanesi
        • Contact:
          • Phone Number: 905322480988
        • Principal Investigator:
          • Irfan Cicin
      • Izmir, Turkey (Türkiye), 35360
        • Recruiting
        • Izmir Ataturk Training and Research Hospital
        • Contact:
          • Phone Number: 905324078648
        • Principal Investigator:
          • Ahmet Alacacioglu
      • Pendik, Turkey (Türkiye), 34899
        • Recruiting
        • Marmara Universitesi Pendik Egitim Arastirma Hastanesi
        • Contact:
          • Phone Number: 905323233799
        • Principal Investigator:
          • Ibrahim Bayoglu
      • Samsun, Turkey (Türkiye), 55200
        • Recruiting
        • Samsun Medical Park Hastanesi
        • Principal Investigator:
          • Dilek Erdem
        • Contact:
          • Phone Number: +905364247616
  • United Kingdom
      • Birmingham, United Kingdom, B9 5SS
        • Recruiting
        • Heartlands Hospital
        • Principal Investigator:
          • Shobhit Baijal
      • East Sussex, United Kingdom, BN2 5BE
        • Recruiting
        • University Hospitals Sussex NHS Foundation Trust
        • Principal Investigator:
          • Kam Zaki
        • Contact:
          • Phone Number: 01273-696955 ext 64601
      • Huddersfield, United Kingdom, HD3 3EA
        • Recruiting
        • Huddersfield Royal Infirmary
        • Principal Investigator:
          • Emma Rathbone
      • London, United Kingdom, SM2 5PT
        • Recruiting
        • Royal Marsden Hospital (Sutton)
        • Principal Investigator:
          • Sanjaykumar Popat
      • London, United Kingdom, SW3 6JJ
        • Recruiting
        • Royal Marsden Hospital (Chelsea)
        • Principal Investigator:
          • Sanjaykumar Popat
      • Manchester, United Kingdom, M20 4BX
        • Recruiting
        • The Christie NHS Foundation Trust
        • Principal Investigator:
          • Colin Lindsay
      • Torquay, United Kingdom, TQ2 7AA
        • Recruiting
        • Torbay Hospital
        • Principal Investigator:
          • Louise Medley
  • United States
    • Alabama
      • Huntsville, Alabama, United States, 35805
        • Recruiting
        • Clearview Cancer Institute
        • Principal Investigator:
          • Jorge Diaz
      • Mobile, Alabama, United States, 36607
        • Suspended
        • Infirmary Cancer Care
    • Arizona
      • Tucson, Arizona, United States, 85719
        • Recruiting
        • The University of Arizona Cancer Center - North Campus
        • Principal Investigator:
          • Linda Garland
        • Contact:
          • Phone Number: 520-626-3434
    • Arkansas
      • Springdale, Arkansas, United States, 72762
        • Recruiting
        • Highlands Oncology Group
        • Principal Investigator:
          • Eric Schaefer
        • Contact:
          • Phone Number: 479-872-8130
    • California
      • Los Angeles, California, United States, 90404
        • Not yet recruiting
        • UCLA Hematology/Oncology - Santa Monica
        • Principal Investigator:
          • Jay Lee
        • Contact:
          • Phone Number: 310-794-7333
      • Oceanside, California, United States, 92056
        • Recruiting
        • Profound Research LLC
        • Principal Investigator:
          • Catherine Quinn
      • Orange, California, United States, 92868
        • Not yet recruiting
        • University of California, Irvine (UCI) Health - UC Irvine Medical Center
        • Principal Investigator:
          • Cathleen Park
      • Palo Alto, California, United States, 94304
        • Recruiting
        • Stanford Cancer Center
        • Contact:
          • Phone Number: 650-725-3081
        • Principal Investigator:
          • Joel Neal
      • San Diego, California, United States, 92108
        • Recruiting
        • Kaiser Permanente San Diego Mission Road
        • Principal Investigator:
          • Eric McGary
      • Walnut Creek, California, United States, 94598
        • Recruiting
        • BASS Cancer Center
        • Principal Investigator:
          • Jewel Johl
    • Connecticut
      • Hartford, Connecticut, United States, 06102
        • Recruiting
        • Hartford Hospital (HH)
        • Principal Investigator:
          • Wylie Hosmer
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20016
        • Not yet recruiting
        • Sibley Memorial Hospital
        • Principal Investigator:
          • Kristen Marrone
    • Florida
      • Boca Raton, Florida, United States, 33486
        • Recruiting
        • Boca Raton Regional Hospital
        • Principal Investigator:
          • Samuel Kareff
      • Fort Myers, Florida, United States, 33901
        • Recruiting
        • Florida Cancer Specialists - South
        • Principal Investigator:
          • Fadi Kayali
      • Jacksonville, Florida, United States, 32209
        • Recruiting
        • University of Florida - Jacksonville
        • Principal Investigator:
          • Pablo Santana
      • Miami, Florida, United States, 33176
        • Recruiting
        • Miami Cancer Institute at Baptist Health, Inc.
        • Principal Investigator:
          • Bruna Pellini
      • Ocala, Florida, United States, 34474
        • Not yet recruiting
        • Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala
        • Contact:
          • Phone Number: 352-732-4032
        • Principal Investigator:
          • Ketan Doshi
      • St. Petersburg, Florida, United States, 33709
        • Recruiting
        • Comprehensive Hematology Oncology
        • Principal Investigator:
          • Neeharika Makani
        • Contact:
          • Phone Number: 727-344-6569
      • St. Petersburg, Florida, United States, 33701-4553
        • Recruiting
        • Florida Cancer Specialists North
        • Principal Investigator:
          • Ernesto Bustinza-Linares
      • Tampa, Florida, United States, 33612
        • Recruiting
        • Moffitt Cancer Center
        • Contact:
          • Phone Number: 813-745-2677
        • Principal Investigator:
          • Jhanelle Gray
      • West Palm Beach, Florida, United States, 33401
        • Recruiting
        • Florida Cancer Specialists East
        • Principal Investigator:
          • Eric Michael Harris
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Not yet recruiting
        • Winship Cancer Institute
        • Principal Investigator:
          • Jennifer Carlisle
    • Illinois
      • Chicago, Illinois, United States, 60637
        • Recruiting
        • University of Chicago Medical Center
        • Principal Investigator:
          • Marina Garassino
        • Contact:
          • Phone Number: 773-834-5387
      • Chicago, Illinois, United States, 60612
        • Recruiting
        • University of Illinois at Chicago
        • Principal Investigator:
          • Frank Weinberg
      • Chicago, Illinois, United States, 60611
        • Not yet recruiting
        • Northwestern Memorial Hospital
        • Principal Investigator:
          • Bilal Anouti
      • North Chicago, Illinois, United States, 60064
        • Recruiting
        • Captain James A. Lovell Federal Health Care Center
        • Principal Investigator:
          • Mukta Pant-Purohit
      • Springfield, Illinois, United States, 62703
        • Recruiting
        • Springfield Clinic Main Campus
        • Principal Investigator:
          • Preet Singh
    • Indiana
      • Fort Wayne, Indiana, United States, 46845
        • Recruiting
        • Parkview Research Center at Parkview Regional Medical Center
        • Principal Investigator:
          • patricia Rich
      • Indianapolis, Indiana, United States, 46237
        • Recruiting
        • Franciscan Health
        • Principal Investigator:
          • Michael Eaton
        • Contact:
          • Phone Number: 317-528-5173
    • Kentucky
      • Lexington, Kentucky, United States, 40503
        • Recruiting
        • Baptist Health Lexington
        • Principal Investigator:
          • Firas Badin
      • Lexington, Kentucky, United States, 40509
        • Recruiting
        • Baptist Health Hamburg
        • Principal Investigator:
          • Firas Badin
      • Lexington, Kentucky, United States, 40509
        • Recruiting
        • CHI Saint Joseph Cancer Center - East
        • Principal Investigator:
          • Nicola Jabbour
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70809
        • Recruiting
        • Mary Bird Perkins Cancer Center
        • Principal Investigator:
          • Victor Lin
        • Contact:
          • Phone Number: 225-215-1185
      • Baton Rouge, Louisiana, United States, 70816
        • Recruiting
        • Ochsner Health Ochsner Cancer Center - Baton Rouge
        • Contact:
          • Phone Number: 504-842-3910
        • Principal Investigator:
          • Ralph Millett
      • New Orleans, Louisiana, United States, 70121
        • Recruiting
        • Ochsner Clinic Foundation
        • Contact:
          • Phone Number: 504-842-3910
        • Principal Investigator:
          • Ralph Millett
    • Maine
      • Westbrook, Maine, United States, 04092
        • Recruiting
        • New England Cancer Specialists
        • Contact:
          • Phone Number: 207-303-3300
        • Principal Investigator:
          • Christian Thomas
    • Maryland
      • Baltimore, Maryland, United States, 21224
        • Not yet recruiting
        • Johns Hopkins Bayview Medical Center
        • Principal Investigator:
          • Kristen Marrone
      • Baltimore, Maryland, United States, 21201
        • Recruiting
        • University of Maryland
        • Principal Investigator:
          • Samuel Rosner
      • Frederick, Maryland, United States, 21702
        • Not yet recruiting
        • James M Stockman Cancer Institute
        • Principal Investigator:
          • Changqing Xie
    • Massachusetts
      • Worcester, Massachusetts, United States, 01606
        • Recruiting
        • Reliant Medical Group
        • Contact:
          • Phone Number: 508-556-5400
        • Principal Investigator:
          • Bradley Switzer
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Not yet recruiting
        • Karmanos Cancer Institute
        • Principal Investigator:
          • Khalil Choucair
    • Missouri
      • St Louis, Missouri, United States, 63131
        • Recruiting
        • Missouri Baptist Medical Center
        • Principal Investigator:
          • Bryan Faller
    • New Jersey
      • Cherry Hill, New Jersey, United States, 08002
        • Recruiting
        • Jefferson Health - Cherry Hill
        • Principal Investigator:
          • Sarah Gordon
      • Sewell, New Jersey, United States, 08080
        • Recruiting
        • Sidney Kimmel Cancer Center - Washington Township
        • Principal Investigator:
          • Sarah Gordon
    • New York
      • New York, New York, United States, 10065
        • Recruiting
        • Memorial Sloan Kettering Cancer Center
        • Principal Investigator:
          • Jamie Chaft
        • Contact:
          • Phone Number: 646-608-3761
      • New York, New York, United States, 10032
        • Recruiting
        • Columbia University Irving Medical Center
        • Principal Investigator:
          • Benjamin Herzberg
        • Contact:
          • Phone Number: 212-305-3997
      • Northport, New York, United States, 11768
        • Not yet recruiting
        • Northport VA Medical Center
        • Contact:
          • Phone Number: 631-261-4400 x12581
        • Principal Investigator:
          • Harold Bien
    • Ohio
      • Canton, Ohio, United States, 44710
        • Not yet recruiting
        • Aultman Hospital
        • Contact:
          • Phone Number: 330-438-6333
        • Principal Investigator:
          • Raza Khan
      • Cleveland, Ohio, United States, 44195
        • Recruiting
        • Cleveland Clinic
        • Principal Investigator:
          • Lukas Delasos
      • Columbus, Ohio, United States, 43210
        • Not yet recruiting
        • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
        • Principal Investigator:
          • Timothy Burns
        • Contact:
          • Phone Number: 614-293-3300
    • Oregon
      • Portland, Oregon, United States, 97239
        • Recruiting
        • Oregon Health and Science University
        • Contact:
          • Phone Number: 971-262-9000
        • Principal Investigator:
          • naga praneeth raja
      • Portland, Oregon, United States, 97213
        • Recruiting
        • Providence Portland Medical Center
        • Principal Investigator:
          • Rachel Sanborn
      • Portland, Oregon, United States, 97225
        • Recruiting
        • Providence St. Vincent Medical Center
        • Principal Investigator:
          • Rachel Sanborn
      • Portland, Oregon, United States, 97227
        • Recruiting
        • Kaiser Permanente Interstate Medical Office Central
        • Principal Investigator:
          • Sandeep Mashru
        • Contact:
          • Phone Number: 503-249-3315
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19107
        • Recruiting
        • Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office
        • Principal Investigator:
          • Sarah Gordon
      • Philadelphia, Pennsylvania, United States, 19114
        • Recruiting
        • Jefferson Hospital Northeast
        • Principal Investigator:
          • Sarah Gordon
      • Pittsburgh, Pennsylvania, United States, 15212
        • Recruiting
        • AHN Allegheny General Hospital
        • Principal Investigator:
          • Ariel Lopez-Chavez
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Not yet recruiting
        • Medical University of South Carolina
        • Principal Investigator:
          • Mariam Alexander
      • West Columbia, South Carolina, United States, 29169
        • Recruiting
        • Lexington Medical Center
        • Principal Investigator:
          • Scott Graupner
        • Contact:
          • Phone Number: 803-794-7511
    • Tennessee
      • Chattanooga, Tennessee, United States, 37404
        • Recruiting
        • Tennessee Oncology Chattanooga
        • Principal Investigator:
          • Wade Iams
      • Knoxville, Tennessee, United States, 37920
        • Recruiting
        • University of Tennessee Medical Center
        • Contact:
          • Phone Number: 865-305-8780
        • Principal Investigator:
          • Ardy Davarifar
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • Tennessee Oncology
        • Principal Investigator:
          • Wade Iams
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • Sarah Cannon Research Institute
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • SCRI Oncology Partners
        • Principal Investigator:
          • Melissa Johnson
    • Texas
      • Fort Worth, Texas, United States, 76104
        • Recruiting
        • The Center for Cancer and Blood Disorders
        • Principal Investigator:
          • Ray Page
        • Contact:
          • Phone Number: 817-759-7000
      • Houston, Texas, United States, 77030
        • Recruiting
        • Houston Methodist Hospital
        • Contact:
          • Phone Number: 713-441-9948
        • Principal Investigator:
          • Jun Zhang
      • Houston, Texas, United States, 77030
        • Recruiting
        • University of Texas MD Anderson Cancer Center
        • Principal Investigator:
          • Marcelo Vailati Negrao
        • Contact:
          • Phone Number: 713-792-6363
      • San Antonio, Texas, United States, 78240
        • Recruiting
        • USO - Texas Oncology - San Antonio
        • Principal Investigator:
          • Krishna Alluri
      • Sugar Land, Texas, United States, 77479
        • Recruiting
        • USO - Texas Oncology Gulf Coast
        • Principal Investigator:
          • Caesar Tin-U
      • The Woodlands, Texas, United States, 77380
        • Recruiting
        • USO - US Oncology Research Network
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
    • Vermont
      • Burlington, Vermont, United States, 05405
        • Recruiting
        • The University of Vermont Medical Center Inc.
        • Principal Investigator:
          • Rohit Singh
    • Virginia
      • Charlottesville, Virginia, United States, 22903
        • Recruiting
        • University of Virginia Health System
        • Principal Investigator:
          • Ryan Gentzler
        • Contact:
          • Phone Number: 434-924-4251
      • Richmond, Virginia, United States, 23219
        • Recruiting
        • VCU Health Adult Outpatient Pavillion
        • Principal Investigator:
          • Renato Martins
        • Contact:
          • Phone Number: 804-828-7999
    • Washington
      • Edmonds, Washington, United States, 98026
        • Recruiting
        • Swedish Cancer Institute - Edmonds
        • Principal Investigator:
          • Perrin Romine
      • Seattle, Washington, United States, 98104
        • Recruiting
        • Swedish Medical Center
        • Principal Investigator:
          • Perrin Romine
      • Spokane Valley, Washington, United States, 99216
        • Recruiting
        • Cancer Care Northwest - Vercler
        • Principal Investigator:
          • Maury Blitman
      • Vancouver, Washington, United States, 98684
        • Recruiting
        • Northwest Cancer Specialists PC
        • Principal Investigator:
          • Anthony Van Ho
    • Wisconsin
      • Madison, Wisconsin, United States, 53792
        • Not yet recruiting
        • University Hospital and UW Health Clinics
        • Contact:
          • Phone Number: 608-261-1500
        • Principal Investigator:
          • Cheryl Czerlanis
      • Milwaukee, Wisconsin, United States, 53226
        • Recruiting
        • Medical College of Wisconsin
        • Principal Investigator:
          • Hui-Zi Chen

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Histological or cytological confirmation of NSCLC.

    • Part A

      1. Clinical Stage II-IIIB (N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
      2. Pathologic Stage II-IIIB (N2) NSCLC treated with initial upfront resection.
    • Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy.
  • Must have disease with evidence of KRAS G12C mutation.
  • Must have known programmed death-ligand 1 (PD-L1) expression
  • Must have an ECOG performance status of 0 or 1.
  • Able to swallow oral medication.
  • Must have adequate laboratory parameters.
  • Contraceptive use should be consistent with local regulations for those participating in clinical studies.

  • Women of childbearing potential must

    • Have a negative pregnancy test.
    • Not be breastfeeding during treatment

Exclusion Criteria:

  • Have known changes in the EGFR or ALK genes.
  • Have another type of cancer that is progressing or required active treatment within the past 2 years before screening.
  • Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
  • Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Part A: Placebo + Pembrolizumab
Participants will receive placebo administered orally in combination with pembrolizumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Drug: Placebo
Administered orally.
Drug: Pembrolizumab
Administered intravenously (IV).
Placebo Comparator: Part B: Placebo + Durvalumab
Participants will receive placebo administered orally in combination with durvalumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Drug: Placebo
Administered orally.
Drug: Durvalumab
Administered IV.
Experimental: Part A: Olomorasib + Pembrolizumab
Participants will receive olomorasib administered orally in combination with pembrolizumab intravenously (IV) for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Drug: Olomorasib
Administered orally.
Other Names:
  • LY3537982
Drug: Pembrolizumab
Administered intravenously (IV).
Experimental: Part B: Olomorasib + Durvalumab
Participants will receive olomorasib administered orally in combination with durvalumab administered IV for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Drug: Olomorasib
Administered orally.
Other Names:
  • LY3537982
Drug: Durvalumab
Administered IV.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Part A: Disease-Free Survival (DFS) by Investigator Assessment
Time Frame: Randomization to disease recurrence or death from any cause (Estimated as approximately 48 months).
DFS by Investigator Assessment
Randomization to disease recurrence or death from any cause (Estimated as approximately 48 months).
Part B: Progression-Free Survival (PFS)
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
PFS per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by blinded independent central review (BICR)
Randomization to disease progression or death from any cause (Estimated as approximately 3 years).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Part A & B: Overall Survival (OS)
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 5 years).
OS
Randomization to disease progression or death from any cause (Estimated as approximately 5 years).
Part A & B: Change from baseline in health-related quality of life (HRQoL), measured by European Organization for Research & Treatment of CancerQualityofLifeQuestionnaire-Core 30 (EORTC QLQ-C30)
Time Frame: Randomization through end of treatment (Estimated as approximately 3 years).
Change from baseline in HRQoL, measured by the EORTC QLQ-C30
Randomization through end of treatment (Estimated as approximately 3 years).
Part B: Progression-Free Survival 2 (PFS2) by investigator assessment
Time Frame: Randomization to disease progression on next line of treatment or death from any cause (Estimated as approximately 3 years).]
PFS2 by investigator assessment
Randomization to disease progression on next line of treatment or death from any cause (Estimated as approximately 3 years).]
Part B: Changes in Non-Small Cell Lung Cancer (NSCLC)-related symptoms, measured by the NSCLC-Symptom Assessment Questionnaire (SAQ)
Time Frame: Randomization through end of treatment (Estimated as approximately 3 years).
Changes in NSCLC-related symptoms, measured by the NSCLC-SAQ
Randomization through end of treatment (Estimated as approximately 3 years).
Part B: Time to worsening of NSCLC-related symptoms, as measured by NSCLC-SAQ
Time Frame: Randomization through end of treatment (Estimated as approximately 3 years).
Time to worsening of NSCLC-related symptoms, as measured by NSCLC-SAQ
Randomization through end of treatment (Estimated as approximately 3 years).
Part B: Changes in patient-reported pulmonary symptoms of cough, chest pain, and dyspnea, measured by NSCLC-SAQ
Time Frame: Randomization through end of treatment (Estimated as approximately 3 years).
Changes in patient-reported pulmonary symptoms of cough, chest pain, and dyspnea, measured by NSCLC-SAQ
Randomization through end of treatment (Estimated as approximately 3 years).
Part B: PFS
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years)
PFS per RECIST v1.1 by Investigator
Randomization to disease progression or death from any cause (Estimated as approximately 3 years)
Part B: Objective Response Rate (ORR) per RECIST 1.1 by BICR and Investigator
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
ORR per RECIST 1.1 by BICR
Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
Part B: Duration of Response (DOR) per RECIST 1.1 by BICR and Investigator
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
DOR per RECIST 1.1 by BICR
Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
Part B: Disease Control Rate (DCR) per RECIST 1.1 by BICR and Investigator
Time Frame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
DCR per RECIST 1.1 by BICR
Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
Part B: Time to Response (TTR) per RECIST 1.1 by BICR and Investigator
Time Frame: Randomization until the date that measurement criteria for CR or PR (whichever is first recorded) are first met (Estimated as approximately 3 years).
TTR per RECIST 1.1 by BICR
Randomization until the date that measurement criteria for CR or PR (whichever is first recorded) are first met (Estimated as approximately 3 years).

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Collaborators

AstraZeneca

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 27, 2025

Primary Completion (Estimated)

May 1, 2029

Study Completion (Estimated)

February 1, 2032

Study Registration Dates

First Submitted

March 18, 2025

First Submitted That Met QC Criteria

March 21, 2025

First Posted (Actual)

March 24, 2025

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 18, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 18763
  • 2024-512302-25-00 (Ctis)
  • J3M-MC-JZQH (Other Identifier: Eli Lilly and Company)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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