Relationship Between Magnesium Depletion Score and Extraction Socket Healing

November 20, 2025 updated by: Saglik Bilimleri Universitesi

Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction

The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH).

SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.

Study Overview

Status

Completed

Conditions

Detailed Description

The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves "the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone." Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.

Study Type

Observational

Enrollment (Actual)

111

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Sultanbeyli
      • Istanbul, Sultanbeyli, Turkey (Türkiye), 34920
        • Sağlık Bilimleri Üniversitesi Tacirler Eğitim Vakfı Sultanbeyli Ağız ve Diş Sağlığı Hastanesi

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Systemically healthy adult participants from both sexes, who were scheduled to undergo surgical extraction of lower impacted third molars, with a physical status classified as ASA I according to the American Society of Anesthesiologists (ASA).

Description

Inclusion Criteria:

  • Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.

Exclusion Criteria:

  • Refusal to consent
  • Presence of chronic diseases
  • Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
  • Prior radiotherapy in the head and neck area
  • Pregnancy
  • Inability to self-evaluate, and inability to communicate verbally or in writing.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Participants aged between 18-75 from both sexes
Systemically healthy participants, aged between 18-75 from both sexes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Magnesium depletion score (MDS)
Time Frame: 6 weeks

The MDS is calculated by aggregating four factors:

  1. Diuretic use: Current use of diuretics is assigned 1 point.
  2. PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point.

  3. Kidney function:

    • If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned.
    • If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned.

The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors.
6 weeks
Assessment of Wound healing (WH)
Time Frame: 6 weeks

Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling.

The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing.
6 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Post-operative pain
Time Frame: 3 days
Post-operative pain will be assessed using the Visual Analog Scale (VAS). Patients will be asked to rate their pain on a scale from 0 to 10, where 0 indicates no pain and 10 represents the worst imaginable pain.
3 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Saglik Bilimleri Universitesi

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 10, 2025

Primary Completion (Actual)

October 22, 2025

Study Completion (Actual)

October 22, 2025

Study Registration Dates

First Submitted

February 4, 2025

First Submitted That Met QC Criteria

March 17, 2025

First Posted (Actual)

March 24, 2025

Study Record Updates

Last Update Posted (Actual)

November 24, 2025

Last Update Submitted That Met QC Criteria

November 20, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 24/738

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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