Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)

May 20, 2026 updated by: Amgen

A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)

This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

5056

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Amgen Call Center
Phone Number: 866-572-6436
Email: medinfo@amgen.com

Study Locations

Argentina
- - Córdoba, Argentina, X5003DCE
    - Recruiting
    - Instituto Médico DAMIC
  - Rosario, Argentina, S2000DSR
    - Recruiting
    - INECO Neurociencias Oronio
  - Santa Fe, Argentina, S3000FWO
    - Recruiting
    - Centro de Investigaciones Clínicas del Litoral
  - Santa Fe, Argentina, S3000EOZ
    - Recruiting
    - Hospital Dr Jose Maria Cullen
  - Zárate, Argentina, 2800
    - Recruiting
    - Instituto de Investigaciones Clínicas Zarate
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1407GTN
    - Recruiting
    - Cemedic Centro de Especialidades Medicas
  - CABA, Buenos Aires, Argentina, C1425AGC
    - Recruiting
    - Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
  - CABA, Buenos Aires, Argentina, C1056ABI
    - Recruiting
    - Centro de Investigaciones Metabolicas Cinme
  - CABA, Buenos Aires, Argentina, 1178
    - Recruiting
    - Imoba Investigaciones medicas
  - CABA, Buenos Aires, Argentina, C1426ABP
    - Recruiting
    - Fundacion Respirar - Consultorios Medicos Dr Doreski
  - CABA, Buenos Aires, Argentina, C1431FWO
    - Recruiting
    - Cemic - Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1061AAT
    - Recruiting
    - Ciprec Centro de Investigacion y Prevencion Cardiovascular
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1425
    - Recruiting
    - Cardiologia Palermo
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1128AAF
    - Recruiting
    - Mautalen Salud e Investigacion Expertia SA-Osteo
  - Morón, Buenos Aires, Argentina, B1708EPE
    - Recruiting
    - Ciad - Consultorio Integral de Atencion al Diabetico
  - Ramos Meija, Buenos Aires, Argentina, B1704ETD
    - Recruiting
    - DIM Clinica Privada
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, 2900
    - Recruiting
    - Go Centro Medico San Nicolás
  - San Nicolás de los Arroyos, Buenos Aires, Argentina, B2900DMH
    - Recruiting
    - Instituto de Investigaciones Clinicas de San Nicolas
- Córdoba Province
  - Villa María, Córdoba Province, Argentina, 5900
    - Recruiting
    - Clinica Fusavim Privada SRL
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, S2000CVD
    - Recruiting
    - Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
  - Rosario, Santa Fe Province, Argentina, S2000PBJ
    - Recruiting
    - Instituto CAICI - Centro de Asistencia e Investigacion Clinica Integral
- Tucumán Province
  - San Miguel de Tucumán, Tucumán Province, Argentina, T4000ICL
    - Recruiting
    - Investigaciones Clinicas Tucuman
  - San Miguel de Tucumán, Tucumán Province, Argentina, 4000
    - Recruiting
    - Centro Modelo de Cardiologia
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Recruiting
    - Canberra Hospital
- New South Wales
  - Liverpool, New South Wales, Australia, 2170
    - Recruiting
    - Sydney Cardiometabolic Centre
  - St Leonards, New South Wales, Australia, 2065
    - Recruiting
    - Royal North Shore Hospital
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Recruiting
    - Advara HeartCare Wesley
  - Birtinya, Queensland, Australia, 4575
    - Recruiting
    - Sunshine Coast University Hospital
  - Herston, Queensland, Australia, 4029
    - Recruiting
    - Royal Brisbane and Womens Hospital
  - Milton, Queensland, Australia, 4064
    - Recruiting
    - Core Research Group Pty Ltd
  - Southport, Queensland, Australia, 4215
    - Recruiting
    - Gold Coast Hospital and Health Service
  - Woolloongabba, Queensland, Australia, 4102
    - Terminated
    - Dr Heart Pty Ltd
- South Australia
  - Bedford Park, South Australia, Australia, 5042
    - Recruiting
    - Flinders Medical Centre
  - Leabrook, South Australia, Australia, 5068
    - Recruiting
    - Advara HeartCare Leabrook
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Recruiting
    - Victorian Heart Hospital
  - Melbourne, Victoria, Australia, 3004
    - Recruiting
    - The Alfred Hospital
  - Mulgrave, Victoria, Australia, 3170
    - Recruiting
    - Advara HeartCare Mulgrave
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - Recruiting
    - Advara HeartCare Joondalup
  - Murdoch, Western Australia, Australia, 6150
    - Recruiting
    - Fiona Stanley Hospital
Austria
- - Braunau am Inn, Austria, 5280
    - Recruiting
    - Krankenhaus Sankt Josef Braunau
  - Graz, Austria, 8036
    - Recruiting
    - Medizinische Universitaet Graz
  - Graz, Austria, 8020
    - Recruiting
    - Pro Kompetenzzentrum fuer Gesundheit
  - Klagenfurt, Austria, 9020
    - Recruiting
    - Klinikum Klagenfurt am Woerthersee
  - Linz, Austria, 4020
    - Recruiting
    - Ordensklinikum Linz Elisabethinen
  - Salzburg, Austria, 5020
    - Recruiting
    - Landeskrankenhaus Salzburg
  - Sankt Pölten, Austria, 3100
    - Recruiting
    - Universitaetsklinikum Sankt Poelten
  - Sankt Pölten, Austria, 3100
    - Recruiting
    - Imed Sankt Poelten
  - Vienna, Austria, 1210
    - Recruiting
    - Krankenhaus Nord - Klinik Floridsdorf
  - Vienna, Austria, 1090
    - Recruiting
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1190
    - Recruiting
    - Ordinationszentrum imedneunzehn privat
  - Vienna, Austria, 1180
    - Recruiting
    - Herz Zentrum Waehring
Belgium
- - Aalst, Belgium, 9300
    - Recruiting
    - Azorg Campus Aalst - Moorselbaan
  - Brussels, Belgium, 1090
    - Recruiting
    - Universitair Ziekenhuis Brussel
  - Dendermonde, Belgium, 9200
    - Recruiting
    - Algemeen Ziekenhuis Sint Blasius
  - Genk, Belgium, 3600
    - Recruiting
    - Ziekenhuis Oost-Limburg - Campus Sint-Jan
  - Ghent, Belgium, 9000
    - Recruiting
    - Universitair Ziekenhuis Gent
  - Ghent, Belgium, 9000
    - Recruiting
    - Algemeen Ziekenhuis Maria Middelares
  - Hasselt, Belgium, 3500
    - Recruiting
    - Jessa Ziekenhuis - Campus Virga Jesse
  - Herentals, Belgium, 2200
    - Recruiting
    - AZ Herentals
  - Kortrijk, Belgium, 8500
    - Recruiting
    - Algemeen Ziekenhuis Groeninge - Campus Kennedylaan
  - Leuven, Belgium, 3000
    - Recruiting
    - Universitair Ziekenhuis Leuven - Campus Gasthuisberg
  - Liège, Belgium, 4000
    - Recruiting
    - Centre Hospitalier Regional De La Citadelle
  - Liège, Belgium, 4000
    - Recruiting
    - Clinique Centre Hospitalier Chrétien MontLégia
  - Roeselare, Belgium, 8800
    - Recruiting
    - AZ Delta Campus Rumbeke
  - Turnhout, Belgium, 2300
    - Recruiting
    - Algemeen Ziekenhuis Turnhout
  - Yvoir, Belgium, 5530
    - Recruiting
    - Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne
Brazil
- - Rio de Janeiro, Brazil, 20241-180
    - Recruiting
    - IBPCLIN Instituto Brasil de Pesquisa Clinica
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29055-450
    - Recruiting
    - Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
- Goiás
  - Goiânia, Goiás, Brazil, 74605-020
    - Recruiting
    - Hospital Das Clinicas Da Universidade Federal De Goias
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - Recruiting
    - Ccih - Consultoria em Controle de Infecção Hospitalar
  - Belo Horizonte, Minas Gerais, Brazil, 31110-580
    - Recruiting
    - Cardresearch Cardiologia Assistencial de Pesquisa
- Paraná
  - Curitiba, Paraná, Brazil, 80730-150
    - Recruiting
    - Núcleo de Pesquisa Clinica
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90410-000
    - Recruiting
    - Hospital de Clinicas de Porto Alegre
  - Porto Alegre, Rio Grande do Sul, Brazil, 91350-280
    - Recruiting
    - Fz Pesquisa e Servicos em Cardiologia Clinica Ltda
- Sergipe
  - Aracaju, Sergipe, Brazil, 49055-530
    - Recruiting
    - jmf Clinica do Coracao ltda
- São Paulo
  - Campinas, São Paulo, Brazil, 13060-080
    - Recruiting
    - Instituto de Pesquisa Clinica de Campinas - Ipecc
  - Campinas, São Paulo, Brazil, 13092-133
    - Recruiting
    - Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema
  - Marília, São Paulo, Brazil, 17515-000
    - Recruiting
    - Instituto do Coracao de Marília
  - Ribeirão Preto, São Paulo, Brazil, 14026-900
    - Recruiting
    - Clinicor Clinica Cardiologica
  - Santo André, São Paulo, Brazil, 09090-790
    - Recruiting
    - Praxis Pesquisa Medica
  - Santo André, São Paulo, Brazil, 09080-110
    - Recruiting
    - Pesquisare Saude Ltda
  - São José do Rio Preto, São Paulo, Brazil, 15090-000
    - Recruiting
    - Hospital de Base de Sao Jose do Rio Preto
  - São Paulo, São Paulo, Brazil, 05403-900
    - Recruiting
    - Instituto do Coracao do Hospital das Clinicas da Faculdade de medicina da Universidade de Sao Paulo
  - Tatuí, São Paulo, Brazil, 18270-170
    - Recruiting
    - Instituto de Molestias Cardiovasculares de Tatui
Bulgaria
- - Burgas, Bulgaria, 8000
    - Recruiting
    - Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
  - Haskovo, Bulgaria, 6300
    - Recruiting
    - Multiprofile Hospital for Active Treatment - Haskovo AD
  - Plovdiv, Bulgaria, 4001
    - Recruiting
    - University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
  - Plovdiv, Bulgaria, 4002
    - Recruiting
    - Medical Center Futuremeds EOOD
  - Sofia, Bulgaria, 1510
    - Recruiting
    - Medical Center Hera EOOD
  - Sofia, Bulgaria, 1309
    - Recruiting
    - Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD
  - Sofia, Bulgaria, 1431
    - Recruiting
    - Diagnostic-Consultative Center Alexandrovska EOOD
  - Sofia, Bulgaria, 1233
    - Recruiting
    - National Multiprofile Transport Hospital Tzar Boris III
  - Sofia, Bulgaria, 1233
    - Recruiting
    - Multiprofile Hospital for Active Treatment Knyaginya Klementina - Sofia EAD
  - Sofia, Bulgaria, 1618
    - Recruiting
    - Diagnostic-Consultative Center XX-Sofia EOOD
  - Sofia, Bulgaria, 1680
    - Recruiting
    - Diagnostic-Consultative Center Convex OOD
  - Veliko Tarnovo, Bulgaria, 5000
    - Recruiting
    - Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
  - Yambol, Bulgaria, 8600
    - Recruiting
    - Specialised Hospital for Active Cardiology Treatment EAD
Canada
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - Recruiting
    - St Boniface Hospital
  - Winnipeg, Manitoba, Canada, R3L 1Z5
    - Recruiting
    - Cardio 1
- Ontario
  - Brampton, Ontario, Canada, L6Z 4N5
    - Recruiting
    - Brampton Clinical Trials
  - Cambridge, Ontario, Canada, N1R 6V6
    - Recruiting
    - Cambridge Cardiac Care Centre
  - Cambridge, Ontario, Canada, N1R 7R1
    - Recruiting
    - Saul Vizel Professional Medicine Corporation - Vizel Cardiac Research
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Recruiting
    - Partners in Advanced Cardiac Evaluation
  - North York, Ontario, Canada, M6B 3H7
    - Recruiting
    - North York Diagnostic and Cardiac Centre
  - Peterborough, Ontario, Canada, K9J 0B2
    - Recruiting
    - Kawartha Cardiology Clinical Trials
  - Sarnia, Ontario, Canada, N7T 4P5
    - Recruiting
    - CardioQuest Research Centre
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Recruiting
    - Heart Health Institute Research Incorporated
  - Stoney Creek, Ontario, Canada, L8J 3W2
    - Recruiting
    - KMH Cardiology Centres Incorporated Hamilton
  - Thunder Bay, Ontario, Canada, P7B 5N3
    - Recruiting
    - Curans Heart Center
  - Toronto, Ontario, Canada, M6G 1M2
    - Recruiting
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M5S 1B2
    - Recruiting
    - Womens College Hospital
  - Winchester, Ontario, Canada, K0C 2K0
    - Recruiting
    - Winchester District Memorial Hospital
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Recruiting
    - Ecogene-21
  - Montreal, Quebec, Canada, H1T 1C8
    - Recruiting
    - Montreal Heart Institute
  - Sherbrooke, Quebec, Canada, J1E 0N8
    - Recruiting
    - Diex Recherche Sherbrooke Est
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Recruiting
    - Diex Recherche Trois Rivieres
Chile
- - Santiago, Chile, 8320000
    - Recruiting
    - Biocinetic servicios medicos limitada
  - Santiago, Chile, 8330034
    - Recruiting
    - Pontificia Universidad Catolica de Chile
  - Valdivia, Chile, 5110683
    - Recruiting
    - Clinical Research Chile SpA
- Cautín
  - Temuco, Cautín, Chile, 4781156
    - Recruiting
    - Centro de Investigacion Clinica del Sur
  - Temuco, Cautín, Chile, 4813299
    - Recruiting
    - Centro de Estudios Cardiologicos y Medicina Interna CECMI
- Concepción
  - Talcahuano, Concepción, Chile, 4270918
    - Recruiting
    - Hospital Las Higueras
- Santiago Metropolitan
  - Independencia, Santiago Metropolitan, Chile
    - Recruiting
    - Fundacion Innovacion Cardiovascular Clinica Ensenada
  - Providencia, Santiago Metropolitan, Chile, 7500587
    - Recruiting
    - Enroll Spa
- Valparaiso
  - Viña del Mar, Valparaiso, Chile, 2520598
    - Recruiting
    - Oncocentro Apys
  - Viña del Mar, Valparaiso, Chile, 2520997
    - Recruiting
    - Cinvec Estudios Clinicos quinta region Limitada
China
- - Shanghai, China, 200120
    - Recruiting
    - Shanghai East Hospital
- Anhui
  - Hefei, Anhui, China, 230601
    - Recruiting
    - The Second Hospital of Anhui Medical University
- Beijing Municipality
  - Beijing, Beijing Municipality, China, 100191
    - Recruiting
    - Peking University Third Hospital
  - Beijing, Beijing Municipality, China, 100050
    - Recruiting
    - Beijing Friendship Hospital, Capital Medical University
  - Beijing, Beijing Municipality, China, 100037
    - Recruiting
    - Fuwai Hospital Chinese Academy of Medical Sciences
  - Beijing, Beijing Municipality, China, 100020
    - Recruiting
    - Beijing Hospital
- Guangdong
  - Guangzhou, Guangdong, China, 519041
    - Recruiting
    - Guangdong Provincial Peoples Hospital
- Hainan
  - Haikou, Hainan, China, 570311
    - Recruiting
    - The Affiliated Hospital of Inner Mongolia Medical University
- Hebei
  - Qinhuangdao, Hebei, China, 066099
    - Recruiting
    - First Hospital of Qinhuangdao
  - Shijiazhuang, Hebei, China, 050000
    - Recruiting
    - The Second Hospital of Hebei Medical University
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - Recruiting
    - The First Affiliated Hospital of Harbin Medical University
- Henan
  - Kaifeng, Henan, China, 475000
    - Recruiting
    - Huaihe Hospital of Henan University
  - Luoyang, Henan, China, 471002
    - Recruiting
    - Luoyang Third Peoples Hospital
  - Zhengzhou, Henan, China, 450052
    - Recruiting
    - The First Affiliated Hospital of Zhengzhou University
- Hubei
  - Wuhan, Hubei, China, 430033
    - Recruiting
    - The Third Peoples Hospital of Hubei Province
- Hunan
  - Changsha, Hunan, China, 410013
    - Recruiting
    - The Third Xiangya Hospital of Central South University
  - Changsha, Hunan, China, 410011
    - Recruiting
    - The Second Xiangya Hospital of Central South University
  - Changsha, Hunan, China, 410015
    - Recruiting
    - The Third Hospital of Changsha
  - Hengyang, Hunan, China, 421001
    - Recruiting
    - Hebei General Hospital
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 014010
    - Recruiting
    - First Affiliated Hospital of Baotou Hospital, Inner
  - Chifeng, Inner Mongolia, China, 024050
    - Recruiting
    - Affiliated Hospital of Chifeng University
- Jiangsu
  - Changzhou, Jiangsu, China, 210300
    - Recruiting
    - The First Peoples Hospital of Changzhou
  - Nanjing, Jiangsu, China, 210011
    - Recruiting
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, Jiangsu, China, 211000
    - Recruiting
    - Zhongda Hospital Southeast University
  - Wuxi, Jiangsu, China, 214023
    - Recruiting
    - Wuxi Peoples Hospital
- Jiangxi
  - Nanchang, Jiangxi, China, 330006
    - Recruiting
    - The First Affiliated Hospital of Nanchang University
  - Pingxiang, Jiangxi, China, 337000
    - Recruiting
    - Pingxiang Peoples Hospital
- Jilin
  - Changchun, Jilin, China, 130021
    - Recruiting
    - The First Bethune Hospital of Jilin University
  - Changchun, Jilin, China, 130041
    - Recruiting
    - The Second Hospital of Jilin University
  - Changchun, Jilin, China, 130021
    - Recruiting
    - Jilin Province Peoples Hospital
  - Changchun, Jilin, China, 130033
    - Recruiting
    - China Japan Union Hospital of Jilin University
  - Siping, Jilin, China, 136000
    - Recruiting
    - Siping City Center Peoples Hospital
- Liaoning
  - Shenyang, Liaoning, China, 110016
    - Recruiting
    - The Peoples Hospital of Liaoning Province
  - Shenyang, Liaoning, China, 110002
    - Recruiting
    - Zhongshan Hospital Affiliated to Dalian University
- Shaanxi
  - Xi'an, Shaanxi, China, 710068
    - Recruiting
    - Shaanxi Provincial Peoples Hospital
  - Xi'an, Shaanxi, China, 710077
    - Recruiting
    - The First Affiliated Hospital of Xi An Medical University
- Shandong
  - Jinan, Shandong, China, 250012
    - Recruiting
    - Qilu Hospital of Shandong University
  - Jinan, Shandong, China, 250013
    - Recruiting
    - Jinan Central Hospital
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, China, 200080
    - Recruiting
    - Shanghai General Hospital
- Shanxi
  - Taiyuan, Shanxi, China, 030001
    - Recruiting
    - First Hospital of Shanxi Medical University
  - Taiyuan, Shanxi, China, 030024
    - Recruiting
    - Shanxi Cardiovascular Hospital
  - Xi’an, Shanxi, China, 710061
    - Recruiting
    - The First Affiliated Hospital of Xi An Jiao Tong University
  - Yuncheng, Shanxi, China, 044000
    - Recruiting
    - Yuncheng Central Hospital
- Sichuan
  - Chengdu, Sichuan, China, 611130
    - Recruiting
    - Chengdu Fifth Peoples Hospital
  - Chongqing, Sichuan, China, 400010
    - Recruiting
    - The Second Affiliated Hospital of Chongqing Medical University
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300121
    - Recruiting
    - Tianjin Peoples Hospital
  - Tianjin, Tianjin Municipality, China, 300457
    - Recruiting
    - TEDA International Cardiovascular Hospital
- Zhejiang
  - Hangzhou, Zhejiang, China, 310003
    - Recruiting
    - The First Affiliated Hospital Zhejiang University School of Medicine
  - Hangzhou, Zhejiang, China, 310016
    - Recruiting
    - Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
  - Lishui, Zhejiang, China, 323000
    - Recruiting
    - Lishui Central Hospital
Czechia
- - Brandýs nad Labem, Czechia, 250 01
    - Recruiting
    - Medicus Services sro
  - Brno, Czechia, 625 00
    - Recruiting
    - Fakultní nemocnice Brno
  - Brno, Czechia, 602 00
    - Recruiting
    - MUDr Libor Nechvatal sro
  - Brno, Czechia, 603 00
    - Recruiting
    - MUDr Karel Kamenik sro
  - Brno, Czechia, 636 00
    - Recruiting
    - Vojenska nemocnice Brno
  - Broumov, Czechia, 550 01
    - Recruiting
    - Edumed sro
  - Bruntál, Czechia, 792 01
    - Recruiting
    - CorMedico sro
  - Havirov - Mesto, Czechia, 736 01
    - Recruiting
    - Dika centrum sro
  - Holešov, Czechia, 769 01
    - Recruiting
    - Kardio Holesov sro
  - Hradec Králové, Czechia, 500 02
    - Recruiting
    - Edumed sro
  - Jaroměř, Czechia, 551 01
    - Recruiting
    - Edumed sro
  - Liberec, Czechia, 460 01
    - Recruiting
    - Kardiologie - Liberec sro
  - Mělník, Czechia, 276 01
    - Recruiting
    - Cevni ambulance Melnik
  - Náchod, Czechia, 547 01
    - Recruiting
    - Edumed sro
  - Olomouc, Czechia, 779 00
    - Recruiting
    - PreventaMed sro
  - Ostrava, Czechia, 702 00
    - Recruiting
    - CCR Ostrava sro
  - Ostrava, Czechia, 702 00
    - Recruiting
    - MUDr Miroslav Koliba sro
  - Pardubice, Czechia, 532 03
    - Recruiting
    - Nemocnice Pardubickeho kraje as
  - Pardubice, Czechia, 530 02
    - Recruiting
    - Pratia Pardubice as
  - Prague, Czechia, 140 21
    - Recruiting
    - Institut klinicke a experimentalni mediciny
  - Prague, Czechia, 110 00
    - Recruiting
    - Kardiologie Vinohrady sro
  - Prague, Czechia, 101 00
    - Recruiting
    - Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci
  - Prague, Czechia, 110 00
    - Recruiting
    - Avicena - kardiologie, interna sro
  - Prague, Czechia, 120 00
    - Recruiting
    - Kardiologie Vinohrady sro
  - Praha 5 - Smichov, Czechia, 150 00
    - Recruiting
    - Kardiologicke centrum MUDr Janky Skrobakove sro
  - Prostějov, Czechia, 796 01
    - Recruiting
    - MUDr Jarmila Otrubova
  - Přerov, Czechia, 750 02
    - Recruiting
    - Kardio Vaclavik sro
  - Slaný, Czechia, 274 01
    - Recruiting
    - Nemocnice Slany
  - Trutnov, Czechia, 541 01
    - Recruiting
    - Kardiologicka ambulance MUDr Ferkl, sro
  - Uherské Hradiště, Czechia, 686 01
    - Recruiting
    - Clinical Trials Service sro
  - Uherské Hradiště, Czechia, 686 01
    - Recruiting
    - Ansaldo sro
  - Ústí nad Labem, Czechia, 400 01
    - Recruiting
    - Kardiologie - Usti nad Labem sro
  - Ústí nad Labem, Czechia, 400 01
    - Recruiting
    - Kardiologicka Ambulance MUDr Michaela Cervinkova, sro
Denmark
- - Aarhus N, Denmark, 8200
    - Completed
    - Aarhus Universitetshospital
  - Esbjerg, Denmark, 6700
    - Recruiting
    - Esbjerg sygehus Syddansk universitetshospital
  - Frederiksberg, Denmark, 2000
    - Recruiting
    - Frederiksberg/Bispebjerg Hospitaler
  - Herlev, Denmark, 2730
    - Recruiting
    - Herlev and Gentofte Hospital
  - Herning, Denmark, 7400
    - Recruiting
    - Regionshospitalet Gødstrup
  - Hvidovre, Denmark, 2650
    - Recruiting
    - Hvidovre Hospital
  - Roskilde, Denmark, 4000
    - Recruiting
    - Sjaellands Universitetshospital, Roskilde
Finland
- - Helsinki, Finland, 00180
    - Recruiting
    - Terveystalo Ruoholahti
  - Helsinki, Finland, 000290
    - Recruiting
    - Helsinki university hospital
  - Jyväskylä, Finland, 40100
    - Recruiting
    - Terveystalo Jyvaskyla
  - Turku, Finland, 20520
    - Recruiting
    - Turku University Hospital Tyks
France
- - Amiens, France, 80054
    - Recruiting
    - Centre Hospitalier Universitaire Amiens Picardie - Site Sud
  - Bron, France, 69677
    - Recruiting
    - Hospices Civils de Lyon Groupement Hospitalier Est - Hopital Louis Pradel
  - Béziers, France, 34525
    - Recruiting
    - Centre Hospitalier de Beziers
  - Dijon, France, 21000
    - Recruiting
    - Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
  - Lille, France, 59000
    - Recruiting
    - Hôpital Privé Le Bois
  - Lille, France, 59037
    - Recruiting
    - Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
  - Montpellier, France, 34090
    - Recruiting
    - Centre Hospitalier Universitaire de Montpellier - Hôpital Arnaud de Villeneuve
  - Nantes, France, 44277
    - Recruiting
    - Hopital prive du Confluent
  - Nice, France, 06000
    - Recruiting
    - Centre Hospitalier Universitaire de Nice - Hopital Pasteur
  - Paris, France, 75012
    - Recruiting
    - Hôpital Saint Antoine
  - Paris, France, 75013
    - Recruiting
    - Hopital Pitie-Salpetriere
  - Paris, France, 75877
    - Recruiting
    - Hopital Bichat Claude Bernard
  - Toulon, France, 83056
    - Recruiting
    - Centre Hospitalier Intercommunal Toulon-La Seyne-sur-Mer - Hopital Sainte Musse
  - Toulouse, France, 31059
    - Recruiting
    - Centre Hospitalier Universitaire de Toulouse - Hôpital Rangueil
  - Tourcoing, France, 59208
    - Recruiting
    - Centre Hospitalier de Tourcoing - Hopital Guy Chatiliez
  - Tours, France, 37044
    - Recruiting
    - Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
Germany
- - Bad Berka, Germany, 99437
    - Recruiting
    - Zentralklinik Bad Berka GmbH
  - Bad Neustadt an der Saale, Germany, 97616
    - Recruiting
    - Rhoehn Klinik Campus Bad Neustadt
  - Bad Segeberg, Germany, 23795
    - Recruiting
    - Segeberger Kliniken GmbH
  - Berlin, Germany, 13353
    - Recruiting
    - Charite - Universitaetsmedizin Berlin, Campus Virchow
  - Berlin, Germany, 12203
    - Recruiting
    - Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
  - Berlin, Germany, 12157
    - Recruiting
    - policum Berlin Friedenau
  - Bonn, Germany, 53127
    - Recruiting
    - Universitaetsklinikum Bonn
  - Detmold, Germany, 32756
    - Recruiting
    - Klinikum Lippe
  - Dresden, Germany, 01307
    - Recruiting
    - Universitaetsklinikum Dresden
  - Dresden, Germany, 01099
    - Recruiting
    - Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden-Neustadt Betriebsgesellschaft
  - Düsseldorf, Germany, 40225
    - Recruiting
    - Universitaetsklinikum Duesseldorf
  - Frankfurt am Main, Germany, 60596
    - Recruiting
    - ClinPhenomics CVC GmbH
  - Frankfurt am Main, Germany, 60596
    - Recruiting
    - Universitaetsklinikum Frankfurt
  - Fulda, Germany, 36037
    - Recruiting
    - Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
  - Hamburg, Germany, 22041
    - Recruiting
    - Cardiologicum Hamburg GbR
  - Hamburg, Germany, 20251
    - Recruiting
    - Universitaetsklinikum Hamburg Eppendorf
  - Haßloch, Germany, 67454
    - Recruiting
    - Kardiologische Praxis
  - Heidelberg, Germany, 69120
    - Recruiting
    - Universitaetsklinikum Heidelberg
  - Homburg, Germany, 66421
    - Recruiting
    - Universitaetsklinikum des Saarlandes
  - Jena, Germany, 07747
    - Recruiting
    - Universitaetsklinikum Jena
  - Kaiserslautern, Germany, 67655
    - Recruiting
    - Kardiopraxis Schirmer
  - Leipzig, Germany, 04103
    - Recruiting
    - Universitaetsklinikum Leipzig
  - Mannheim, Germany, 68165
    - Recruiting
    - zero Praxen GbR
  - Minden, Germany, 32429
    - Recruiting
    - Johannes Wesling Klinikum Minden
  - München, Germany, 80809
    - Recruiting
    - Klinikum rechts der Isar der TUM
  - Offenbach, Germany, 63065
    - Recruiting
    - FutureMeds Offenbach
  - Papenburg, Germany, 26871
    - Recruiting
    - Kardiologische Gemeinschaftspraxis Papenburg
  - Regensburg, Germany, 93053
    - Recruiting
    - Universitaetsklinikum Regensburg
  - Siegen, Germany, 57072
    - Recruiting
    - Herz- und Gefaesszentrum Praxis Dr Overhoff Dr Kraemer
  - Ulm, Germany, 89077
    - Recruiting
    - Cardiologicum Herzklinik Ulm
  - Wermsdorf, Germany, 04779
    - Recruiting
    - Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie
Greece
- - Alexandroupoli, Greece, 68100
    - Recruiting
    - University Hospital of Alexandroupolis
  - Athens, Greece, 11521
    - Recruiting
    - Athens Naval Hospital
  - Athens, Greece, 11527
    - Recruiting
    - General Hospital of Athens Georgios Gennimatas
  - Athens, Greece, 11527
    - Recruiting
    - General Hospital of Athens Ippokrateio
  - Athens, Greece, 11528
    - Recruiting
    - Alexandra Hospital
  - Athens, Greece, 11527
    - Recruiting
    - General Hospital for Thoracic Diseases of Athens "Sotiria
  - Athens, Greece, 16673
    - Recruiting
    - General Hospital Asklipieio Voulas
  - Athens, Greece, 12462
    - Recruiting
    - University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
  - Chios, Greece, 82131
    - Recruiting
    - General Hospital of Chios "Skilitsion"
  - Larissa, Greece, 41110
    - Recruiting
    - University Hospital of Larissa
  - Marousi, Greece, 15123
    - Recruiting
    - Hygeia Hospital
  - Nea Ionia, Greece, 14233
    - Recruiting
    - General Hospital Of Nea Ionia Konstantopouleio Patision
  - Piraeus, Greece, 18536
    - Recruiting
    - Tzaneio General Hospital
  - Thessaloniki, Greece, 54636
    - Recruiting
    - Ahepa University Hospital
Hong Kong
- - Hong Kong, Hong Kong
    - Recruiting
    - Queen Mary Hospital, The University of Hong Kong
  - Shatin, New Territories, Hong Kong
    - Recruiting
    - Prince of Wales Hospital, Chinese University of Hong Kong
Hungary
- - Budapest, Hungary, 1106
    - Recruiting
    - Bajcsy-Zsilinszky Kórház és Rendelőintézet
  - Budapest, Hungary, 1021
    - Recruiting
    - Budapesti Szent Ferenc Korhaz
  - Budapest, Hungary, 1122
    - Recruiting
    - Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika
  - Budapest, Hungary, 1134
    - Recruiting
    - Eszak-Pesti Centrum Korhaz - Honvedkorhaz
  - Budapest, Hungary, 1145
    - Recruiting
    - Budapesti Uzsoki Utcai Kórház
  - Budapest, Hungary, 1148
    - Recruiting
    - Zugloi Egeszsegugyi Szolgalat
  - Budapest, Hungary, 1066
    - Recruiting
    - Geomedical Orvosi Kft
  - Debrecen, Hungary, 4032
    - Recruiting
    - Debreceni Egyetem Klinikai Kozpont
  - Gyöngyös, Hungary, 3200
    - Recruiting
    - Gyongyosi Bugat Pal Korhaz
  - Győr, Hungary, 9024
    - Recruiting
    - Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
  - Kecskemét, Hungary, 6000
    - Recruiting
    - Bács-Kiskun Vármegyei Oktatókórház
  - Keszthely, Hungary, 8360
    - Recruiting
    - Keszthelyi Korhaz
  - Kistarcsa, Hungary, 2143
    - Recruiting
    - Kistarcsai Flor Ferenc Korhaz
  - Komárom, Hungary, 2921
    - Recruiting
    - Komáromi Selye János Kórház
  - Nyíregyháza, Hungary, 4400
    - Recruiting
    - Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
  - Orosháza, Hungary, 5900
    - Recruiting
    - Oroshazi Dr Laszlo Elek Korhaz es Rendelointezet
  - Pécs, Hungary, 7623
    - Recruiting
    - Coromed-Smo Kft
  - Pécs, Hungary, 7635
    - Recruiting
    - DaVinci Maganklinika
  - Szeged, Hungary, 6725
    - Recruiting
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
  - Szekszárd, Hungary, 7100
    - Recruiting
    - Tolna Varmegyei Balassa Janos Korhaz
  - Szentes, Hungary, 6600
    - Recruiting
    - Szegedi Tudomanyegyetem SZGYA Klinikai Kozpont Dr Bugyi Istvan Szentesi Multidiszciplinaris Centrum
  - Szolnok, Hungary, 5000
    - Recruiting
    - Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Rendelőintézet
  - Szombathely, Hungary, 9700
    - Recruiting
    - Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
  - Székesfehérvár, Hungary, 8000
    - Recruiting
    - Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
  - Zalaegerszeg, Hungary, 8900
    - Recruiting
    - Zala Varmegyei Szent Rafael Korhaz
Italy
- - Bari, Italy, 70124
    - Recruiting
    - Azienda Ospedaliero Universitaria Consorziale Policlinico
  - Bergamo, Italy, 24127
    - Recruiting
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
  - Brescia, Italy, 25123
    - Recruiting
    - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
  - Cortona AR, Italy, 52044
    - Recruiting
    - Azienda Unita Sanitaria Locale Toscana sud est Ospedale S. Margherita
  - Foggia, Italy, 71122
    - Recruiting
    - Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
  - Forlì, Italy, 47121
    - Recruiting
    - Azienda Unita Sanitaria Locale Romagna
  - Milan, Italy, 20132
    - Recruiting
    - Irccs Ospedale San Raffaele
  - Milan, Italy, 20138
    - Recruiting
    - IRCCS Centro Cardiologico Monzino
  - Naples, Italy, 80131
    - Recruiting
    - Azienda Ospedaliera Universitaria Federico II
  - Naples, Italy, 80131
    - Recruiting
    - Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi
  - Pavia, Italy, 27100
    - Recruiting
    - Fondazione IRCCS Policlinico San Matteo
  - Rimini, Italy, 47923
    - Recruiting
    - Azienda Unita Sanitaria Locale Romagna
  - Rivoli, Italy, 10098
    - Recruiting
    - ASL TO3 Ospedale di Rivoli
  - Roma, Italy, 00128
    - Recruiting
    - Fondazione Policlinico Universitario Campus Bio-Medico
  - Sassari, Italy, 07100
    - Recruiting
    - Azienda Ospedaliero Universitaria di Sassari
Japan
- Aichi-ken
  - Toyoake-shi, Aichi-ken, Japan, 470-1192
    - Recruiting
    - Fujita Health University Hospital
- Fukuoka
  - Fukuoka, Fukuoka, Japan, 814-0180
    - Recruiting
    - Fukuoka University Hospital
- Hokkaido
  - Sapporo, Hokkaido, Japan, 063-0826
    - Recruiting
    - Miyanosawa Clinic of Internal Medicine and Cardiology
- Hyōgo
  - Takarazuka-shi, Hyōgo, Japan, 665-0873
    - Recruiting
    - Higashi Takarazuka Satoh Hospital
- Ishikawa-ken
  - Kanazawa, Ishikawa-ken, Japan, 920-8530
    - Recruiting
    - Ishikawa Prefectural Central Hospital
- Kagawa-ken
  - Takamatsu, Kagawa-ken, Japan, 760-0017
    - Recruiting
    - Takamatsu Red Cross Hospital
- Kagoshima-ken
  - Kagoshima, Kagoshima-ken, Japan, 892-0822
    - Recruiting
    - Tenyoukai Central Clinic
- Kanagawa
  - Sagamihara-shi, Kanagawa, Japan, 252-5188
    - Recruiting
    - Sagamihara Kyodo Hospital
- Kumamoto
  - Kumamoto, Kumamoto, Japan, 860-8518
    - Recruiting
    - Kumamoto Kinoh Hospital
- Kyoto
  - Kyoto, Kyoto, Japan, 607-8062
    - Recruiting
    - Rakuwakai Otowa Hospital
- Nagano
  - Kitaazumi-gun, Nagano, Japan, 399-8695
    - Recruiting
    - North Alps Medical Center Azumi Hospital
- Niigata
  - Niigata, Niigata, Japan, 951-8520
    - Recruiting
    - Niigata University Medical and Dental Hospital
- Oita Prefecture
  - Ōita, Oita Prefecture, Japan, 870-0033
    - Recruiting
    - Oita Red Cross Hospital
- Shizuoka
  - Fujinomiya-shi, Shizuoka, Japan, 418-0076
    - Recruiting
    - Fujinomiya City General Hospital
  - Hamamatsu, Shizuoka, Japan, 434-8533
    - Recruiting
    - Japanese Red Cross Hamamatsu Hospital
- Tokyo
  - Hachioji-shi, Tokyo, Japan, 192-0918
    - Recruiting
    - Medical Corporation Kenshinkai Minamino Cardiovascular Hospital
  - Higashiyamato-shi, Tokyo, Japan, 207-0014
    - Recruiting
    - Affiliated Central Clinic of Higashiyamato Hospital
  - Shinagawa-ku, Tokyo, Japan, 140-8522
    - Recruiting
    - Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai
  - Suginami-ku, Tokyo, Japan, 168-0065
    - Recruiting
    - NewHeart Watanabe Institute
- Tottori
  - Yonago-shi, Tottori, Japan, 683-8605
    - Recruiting
    - Sanin Rosai Hospital
Mexico
- - Aguascalientes, Mexico, 20230
    - Recruiting
    - Hospital Cardiologica Aguascalientes
- Mexico City
  - Mexico City, Mexico City, Mexico, 03650
    - Recruiting
    - Soluciones Terapeuticas Medico Quirurgicas
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64060
    - Recruiting
    - Cardiolink Clin Trials
- Querétaro
  - Juriquilla, Querétaro, Mexico, 76230
    - Recruiting
    - Health Pharma Queretaro SA de CV
  - Querétaro City, Querétaro, Mexico, 76000
    - Recruiting
    - Centro de Estudios Clinicos de Queretaro
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Recruiting
    - Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
Netherlands
- - Amsterdam, Netherlands, 1081 HV
    - Recruiting
    - Amsterdam Universitair Medisch Centrum
  - Arnhem, Netherlands, 6815 AD
    - Recruiting
    - Rijnstate Ziekenhuis
  - Breda, Netherlands, 4818 CK
    - Recruiting
    - Amphia Ziekenhuis
  - Delft, Netherlands, 2625 AD
    - Recruiting
    - Reinier de Graaf Gasthuis
  - Deventer, Netherlands, 7416 SE
    - Recruiting
    - Deventer Ziekenhuis
  - Dordrecht, Netherlands, 3318 AT
    - Recruiting
    - Albert Schweitzer Ziekenhuis, Locatie Dordwijk
  - Eindhoven, Netherlands, 5623 EJ
    - Recruiting
    - Catharina Ziekenhuis
  - Emmen, Netherlands, 7824 AA
    - Recruiting
    - Treant Zorggroep, locatie Scheper ziekenhuis Emmen
  - Enschede, Netherlands, 7512 KZ
    - Recruiting
    - Medisch Spectrum Twente
  - Groningen, Netherlands, 9713 GZ
    - Recruiting
    - Universitair Medisch Centrum Groningen
  - Heerlen, Netherlands, 6419 PC
    - Recruiting
    - Zuyderland Medisch Centrum
  - Leeuwarden, Netherlands, 8934 AD
    - Recruiting
    - Frisius Medisch Centrum, locatie Leeuwarden
  - Rotterdam, Netherlands, 3083 AN
    - Recruiting
    - Ikazia Ziekenhuis
  - Sneek, Netherlands, 8601 ZR
    - Recruiting
    - D and A Research and Genetics
  - The Hague, Netherlands, 2545 AA
    - Recruiting
    - Haga Ziekenhuis
  - Zaandam, Netherlands, 1502 DV
    - Recruiting
    - Zaans Medisch Centrum
Poland
- - Bialystok, Poland, 15-704
    - Recruiting
    - Marek Dariusz Klimkiewicz Klimed Marek Klimkiewicz
  - Bydgoszcz, Poland, 85-605
    - Recruiting
    - Centrum medyczne intercore sp zoo
  - Chrzanów, Poland, 32-500
    - Recruiting
    - American Heart of Poland Spolka Akcyjna
  - Elblag, Poland, 82-300
    - Recruiting
    - Centrum Badan Klinicznych Agnieszka Mital
  - Gdansk, Poland, 80-214
    - Recruiting
    - Uniwersyteckie Centrum Kliniczne
  - Gdynia, Poland, 81-423
    - Recruiting
    - Pawel Miekus, NZOZ Sopockie Centrum Badan Kardiologicznych ProCordis Pawel Miekus
  - Giżycko, Poland, 11-500
    - Recruiting
    - Niepubliczny Zaklad Opieki Zdrowotnej Medica Jerzy Cygler
  - Katowice, Poland, 40-648
    - Recruiting
    - Pro Familia Altera Sp zoo
  - Krakow, Poland, 31-501
    - Recruiting
    - Futuremeds spolka z ograniczona odpowiedzialnoscia
  - Lodz, Poland, 91-363
    - Recruiting
    - Futuremeds spolka z ograniczona odpowiedzialnoscia
  - Lodz, Poland, 90-549
    - Recruiting
    - SPZOZ Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
  - Lublin, Poland, 20-044
    - Recruiting
    - CenterMed Spzoo Centermed Lublin
  - Miechów, Poland, 32-200
    - Recruiting
    - Szpital Swietej Anny w Miechowie
  - Olsztyn, Poland, 10-165
    - Recruiting
    - Futuremeds spolka z ograniczona odpowiedzialnoscia
  - Oświęcim, Poland, 32-600
    - Recruiting
    - Medicome Spolka z Ograniczona Odpowiedzialnoscia
  - Rzeszów, Poland, 35-055
    - Recruiting
    - Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa
  - Skierniewice, Poland, 96-100
    - Recruiting
    - Velocity Skierniewice Spolka z Ograniczona Odpowiedzialnoscia
  - Torun, Poland, 87-100
    - Recruiting
    - Praktyka Lekarska Lidia Pawlowicz
  - Tychy, Poland, 43-100
    - Recruiting
    - American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
  - Warsaw, Poland, 02-507
    - Recruiting
    - Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
  - Warsaw, Poland, 02-758
    - Recruiting
    - Gabinet Lekarski Maciej Karcz
  - Warsaw, Poland, 01-018
    - Recruiting
    - Oha-Med Sp zoo
  - Wroclaw, Poland, 50-556
    - Recruiting
    - Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu
  - Wroclaw, Poland, 53-673
    - Recruiting
    - Futuremeds spolka z ograniczona odpowiedzialnoscia
  - Żarów, Poland, 58-130
    - Recruiting
    - Halina Serafin NZOZ Centrum Medyczne "Serafin-Med"
Portugal
- - Almada, Portugal, 2801-951
    - Recruiting
    - Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta
  - Coimbra, Portugal, 3000-075
    - Recruiting
    - Unidade Local de Saude de Coimbra, EPE
  - Guimarães, Portugal, 4835-044
    - Recruiting
    - Unidade Local de Saúde do Alto Ave, EPE
  - Lisbon, Portugal, 1649-035
    - Recruiting
    - Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
  - Lisbon, Portugal, 1449-005
    - Recruiting
    - Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier
  - Matosinhos Municipality, Portugal, 4464-513
    - Recruiting
    - Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
  - Porto, Portugal, 4200-319
    - Recruiting
    - Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
Romania
- - Baia Mare, Romania, 430124
    - Recruiting
    - Cardioplus Center SRL
  - Baia Mare, Romania, 430222
    - Recruiting
    - cmi Cardiologie - Dr Pop Calin
  - Brasov, Romania, 500283
    - Recruiting
    - Centrul Medical de Diagnostic si Tratament Ambulator NEOMED
  - Brasov, Romania, 500102
    - Recruiting
    - Thera Card SRL
  - Bucharest, Romania, 050098
    - Recruiting
    - Spitalul Universitar de Urgenta Bucuresti
  - Buzău, Romania, 120133
    - Recruiting
    - Matcord Biomedica Buzau
  - Iași, Romania, 700544
    - Recruiting
    - Consultmed SRL
  - Piteşti, Romania, 110438
    - Recruiting
    - Sal Med Srl
  - Timișoara, Romania, 300079
    - Recruiting
    - Spitalul Clinic Municipal de Urgenta Timisoara
  - Târgu Mureş, Romania, 540136
    - Recruiting
    - Spitalul Clinic Judetean de Urgenta Targu Mures
  - Târgu Mureş, Romania, 540143
    - Recruiting
    - Cabinet Medical Individual Dr Podoleanu Cristian
Slovakia
- - Bardejov, Slovakia, 085 01
    - Recruiting
    - Alian, sro
  - Bardejov, Slovakia, 085 01
    - Recruiting
    - HeartCare sro
  - Bratislava, Slovakia, 833 48
    - Recruiting
    - Narodny ustav srdcovych a cievnych chorob, as
  - Bratislava, Slovakia, 841 04
    - Recruiting
    - Novate sro
  - Dolný Kubín, Slovakia, 026 01
    - Recruiting
    - Kardiomedina sro
  - Kežmarok, Slovakia, 060 01
    - Recruiting
    - Nemocnica Dr Vojtecha Alexandra v Kezmarku no
  - Košice, Slovakia, 040 22
    - Recruiting
    - Cardio D and R, sro Kosice
  - Košice, Slovakia, 040 01
    - Recruiting
    - Medical group Kosice sro
  - Levoča, Slovakia, 054 01
    - Recruiting
    - KardioLEV sro
  - Lučenec, Slovakia, 984 01
    - Recruiting
    - Kardio 1 sro
  - Malacky, Slovakia, 901 22
    - Recruiting
    - Nemocnicna as
  - Nové Zámky, Slovakia, 940 01
    - Recruiting
    - Kardiomed NZ, sro
  - Nové Zámky, Slovakia, 940 02
    - Recruiting
    - KaCH, sro
  - Námestovo, Slovakia, 029 01
    - Recruiting
    - Oralek, sro
  - Poprad, Slovakia, 058 45
    - Recruiting
    - Nemocnica Poprad, as
  - Prešov, Slovakia, 080 01
    - Recruiting
    - Intermedis sro
  - Prešov, Slovakia, 080 01
    - Recruiting
    - Medispol, sro
  - Svidník, Slovakia, 089 01
    - Recruiting
    - Interna SK, sro
  - Žilina, Slovakia, 010 01
    - Recruiting
    - Pentes, sro
South Korea
- - Seongnam-si, Gyeonggi-do, South Korea, 13620
    - Recruiting
    - Seoul National University Bundang Hospital
  - Seoul, South Korea, 03080
    - Recruiting
    - Seoul National University Hospital
  - Seoul, South Korea, 03722
    - Recruiting
    - Severance Hospital Yonsei University Health System
  - Wonju-si, Gangwon-do, South Korea, 26426
    - Recruiting
    - Yonsei University Wonju Severance Christian Hospital
Spain
- - Madrid, Spain, 28041
    - Recruiting
    - Hospital Universitario 12 de Octubre
  - Madrid, Spain, 28046
    - Recruiting
    - Hospital Universitario La Paz
  - Madrid, Spain, 28040
    - Recruiting
    - Hospital Clinico San Carlos
  - Salamanca, Spain, 37007
    - Recruiting
    - Hospital Clinico Universitario de Salamanca
- Andalusia
  - Córdoba, Andalusia, Spain, 14004
    - Recruiting
    - Hospital Universitario Reina Sofia
  - Málaga, Andalusia, Spain, 29010
    - Recruiting
    - Hospital Clinico Universitario Virgen de La Victoria
- Canary Islands
  - Las Palmas de Gran Canaria, Canary Islands, Spain, 35010
    - Recruiting
    - Hospital Universitario de Gran Canaria Doctor Negrin
- Catalonia
  - Badalona, Catalonia, Spain, 08916
    - Recruiting
    - Hospital Universitari Germans Trias i Pujol
  - Barcelona, Catalonia, Spain, 08035
    - Recruiting
    - Hospital Universitari Vall d Hebron
  - Barcelona, Catalonia, Spain, 08036
    - Recruiting
    - Hospital Clinic i Provincial de Barcelona
  - L'Hospitalet de Llobregat, Catalonia, Spain, 08907
    - Recruiting
    - Hospital Universitari de Bellvitge
  - Lleida, Catalonia, Spain, 25198
    - Recruiting
    - Hospital Universitario Arnau de Vilanova Lleida
- Galicia
  - A Coruña, Galicia, Spain, 15006
    - Recruiting
    - Complexo Hospitalario Universitario A Coruña
- Madrid
  - Majadahonda, Madrid, Spain, 28222
    - Recruiting
    - Hospital Universitario Puerta de Hierro Majadahonda
- Murcia
  - El Palmar, Murcia, Spain, 30120
    - Recruiting
    - Hospital Universitario Virgen de La Arrixaca
- Valencia
  - Denia, Valencia, Spain, 03700
    - Recruiting
    - Hospital Marina Salud de Denia
  - Valencia, Valencia, Spain, 46010
    - Recruiting
    - Hospital Clinico Universitario de Valencia
  - Valencia, Valencia, Spain, 46026
    - Recruiting
    - Hospital Universitari i Politècnic La Fe
  - Valencia, Valencia, Spain, 46026
    - Recruiting
    - Hospital Vithas Valencia Turia
Sweden
- - Falun, Sweden, 791 82
    - Recruiting
    - Falu Lasarett
  - Gothenburg, Sweden, 405 45
    - Recruiting
    - Carlanderska sjukhuset
  - Helsingborg, Sweden, 251 87
    - Recruiting
    - Helsingborgs lasarett
  - Lund, Sweden, 222 21
    - Recruiting
    - Clemenstorgets Hjartmottagning
  - Norrköping, Sweden, 601 82
    - Recruiting
    - Vrinnevisjukhuset i Norrkoeping
  - Solna, Sweden, 171 76
    - Recruiting
    - Karolinska Universitetssjukhuset Solna
  - Stockholm, Sweden, 182 88
    - Recruiting
    - Danderyds Sjukhus
  - Stockholm, Sweden, 112 19
    - Recruiting
    - Capio Saint Gorans Hospital
Switzerland
- - Basel, Switzerland, 4031
    - Recruiting
    - Universitaetsspital Basel
  - Bern, Switzerland, 3010
    - Recruiting
    - Inselspital Bern
  - Geneva, Switzerland, 1211
    - Recruiting
    - Hopitaux universitaires de Geneve
  - Lausanne, Switzerland, 1011
    - Recruiting
    - Centre Hospitalier Universitaire Vaudois
  - Lugano, Switzerland, 6900
    - Recruiting
    - Istituto Cardiocentro Ticino
  - Sankt Gallen, Switzerland, 9007
    - Recruiting
    - Kantonsspital Sankt Gallen
Taiwan
- - Kaohsiung City, Taiwan, 80756
    - Recruiting
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - Taichung, Taiwan, 40447
    - Recruiting
    - China Medical University Hospital
  - Tainan, Taiwan, 70403
    - Recruiting
    - National Cheng Kung University Hospital
  - Taipei, Taiwan, 10002
    - Recruiting
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Recruiting
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 11031
    - Recruiting
    - Taipei Medical University Hospital
Turkey (Türkiye)
- - Afyonkarahisar, Turkey (Türkiye), 03218
    - Recruiting
    - Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi
  - Ankara, Turkey (Türkiye), 06800
    - Recruiting
    - Ankara Bilkent Sehir Hastanesi
  - Istanbul, Turkey (Türkiye), 34214
    - Recruiting
    - Bagcilar Medipol Mega Universite Hastanesi
  - Istanbul, Turkey (Türkiye), 34722
    - Recruiting
    - Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
  - Istanbul, Turkey (Türkiye), 34096
    - Recruiting
    - Istanbul Universitesi Cerrahpasa Tip Fakultesi
  - Istanbul, Turkey (Türkiye), 34307
    - Recruiting
    - Mehmet Akif Ersoy Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi
  - Istanbul, Turkey (Türkiye), 34668
    - Recruiting
    - Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi
  - Izmir, Turkey (Türkiye), 35340
    - Recruiting
    - Dokuz Eylul Universitesi Tip Fakültesi Hastanesi
  - Kayseri, Turkey (Türkiye), 38039
    - Recruiting
    - Erciyes Universitesi Tip Fakultesi Hastanesi
  - Kocaeli, Turkey (Türkiye), 41380
    - Recruiting
    - Kocaeli Universitesi Tip Fakultesi Hastanesi
  - Konya, Turkey (Türkiye)
    - Recruiting
    - Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi
  - Çorum, Turkey (Türkiye), 19040
    - Recruiting
    - Hitit Universitesi Erol Olcok Egitim ve Arastirma Hastanesi
United Kingdom
- - Airdrie, United Kingdom, ML6 0JS
    - Recruiting
    - University Hospital Monklands
  - Ashington, United Kingdom, NE63 9JJ
    - Recruiting
    - North Tyneside General Hospital
  - Bournemouth, United Kingdom, BH7 7DW
    - Recruiting
    - Royal Bournemouth Hospital
  - Bridgend, United Kingdom, CF31 1RQ
    - Recruiting
    - Princess of Wales Hospital
  - Bristol, United Kingdom, BS10 5NB
    - Recruiting
    - Southmead Hospital
  - Chichester, United Kingdom, PO19 6SE
    - Recruiting
    - St Richards Hospital
  - Dundee, United Kingdom, DD1 9SY
    - Recruiting
    - Ninewells Hospital and Medicine School
  - Exeter, United Kingdom, EX2 5DW
    - Recruiting
    - Royal Devon and Exeter Hospital
  - Glasgow, United Kingdom, G31 2ER
    - Recruiting
    - Glasgow Royal Infirmary
  - High Wycombe, United Kingdom, HP11 2TT
    - Recruiting
    - Wycombe Hospital
  - Inverness, United Kingdom, IV2 3UJ
    - Recruiting
    - Highlands Clinical Research Facility, Raigmore Hospital
  - Kilmarnock, United Kingdom, KA2 0BE
    - Recruiting
    - University Hospital Crosshouse
  - Leicester, United Kingdom, LE3 9QP
    - Recruiting
    - Glenfield Hospital
  - London, United Kingdom, NW1 2BU
    - Recruiting
    - University College London Hospital
  - Manchester, United Kingdom, M13 9WL
    - Recruiting
    - Manchester Royal Infirmary
  - Newcastle upon Tyne, United Kingdom, NE7 7DN
    - Recruiting
    - Newcastle NIHR Commercial Research Delivery Centre
  - Wakefield, United Kingdom, WF1 4DG
    - Recruiting
    - Pinderfields Hospital
United States
- Alabama
  - Birmingham, Alabama, United States, 35205
    - Recruiting
    - University of Alabama at Birmingham
  - Dothan, Alabama, United States, 36305
    - Recruiting
    - SEC Clinical Research
  - Fairhope, Alabama, United States, 36532
    - Recruiting
    - Eastern Shore Research Institute
  - Huntsville, Alabama, United States, 35801-4317
    - Recruiting
    - Heart Center Research Llc
- Arizona
  - Phoenix, Arizona, United States, 85044
    - Recruiting
    - Medical Advancement Centers of Arizona
  - Phoenix, Arizona, United States, 85006
    - Recruiting
    - Honorhealth
  - Tucson, Arizona, United States, 85704
    - Recruiting
    - Pima Heart and Vascular Clinical Research
  - Yuma, Arizona, United States, 85365
    - Recruiting
    - Yuma Clinical Trials
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Recruiting
    - Arkansas Cardiology
- California
  - Beverly Hills, California, United States, 90211
    - Recruiting
    - National Heart Institute
  - Covina, California, United States, 91723
    - Recruiting
    - Valley Clinical Trials, LLC dba Flourish Research
  - Huntington Beach, California, United States, 92648
    - Recruiting
    - National Institute of Clinical Research
  - Inglewood, California, United States, 90301
    - Recruiting
    - 310 Clinical Research
  - Newport Beach, California, United States, 92663
    - Recruiting
    - Radin Cardiovascular Medical Group
  - Northridge, California, United States, 91325
    - Recruiting
    - Valley Clinical Trials
  - Orange, California, United States, 92868
    - Recruiting
    - University of California Irvine
  - Pomona, California, United States, 91767
    - Recruiting
    - Empire Clinical Research
  - San Diego, California, United States, 92123
    - Recruiting
    - San Diego Cardiac Center
  - Santa Rosa, California, United States, 95405
    - Recruiting
    - NorthBay Clinical Research LLC
  - Stockton, California, United States, 95204
    - Recruiting
    - Manshadi Heart Institute
- Connecticut
  - Stamford, Connecticut, United States, 06905
    - Recruiting
    - Cardiology Associates of Fairfield County PC
- Florida
  - Altamonte Springs, Florida, United States, 32714
    - Recruiting
    - Orlando Heart and Vascular Institute
  - Aventura, Florida, United States, 33180
    - Recruiting
    - D and H Tamarac Research Center
  - Boca Raton, Florida, United States, 33434
    - Recruiting
    - Excel Medical Clinical Trials
  - Bradenton, Florida, United States, 34209
    - Recruiting
    - Cardiovascular and Vein Center of Florida
  - Coral Gables, Florida, United States, 33134
    - Recruiting
    - Millennium Medical Research
  - Hialeah, Florida, United States, 33013
    - Recruiting
    - Elite Cardiac Research Center LLC
  - Hollywood, Florida, United States, 33024
    - Recruiting
    - Encore Medical Research LLC
  - Inverness, Florida, United States, 34452
    - Recruiting
    - Nature Coast Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - Jacksonville Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - East Coast Institute for Research
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - First Coast Cardiovascular Institute PA
  - Largo, Florida, United States, 33777
    - Recruiting
    - Clearwater Cardiovascular Consultants
  - Ocala, Florida, United States, 34471
    - Recruiting
    - Ocala Cardiovascular Research
  - Orlando, Florida, United States, 32806
    - Recruiting
    - Orlando Health Heart Institute
  - Ormond Beach, Florida, United States, 32174
    - Recruiting
    - Ormond Beach Clinical Research
  - Pembroke Pines, Florida, United States, 33024
    - Recruiting
    - Broward Research Center
  - Pensacola, Florida, United States, 32504
    - Recruiting
    - Ascension Sacred Heart
  - Sarasota, Florida, United States, 34239
    - Recruiting
    - Cardiovascular Center Of Sarasota
  - Wellington, Florida, United States, 33449
    - Recruiting
    - Cardiology Partners Clinical Research Institute
  - Winter Park, Florida, United States, 32792
    - Recruiting
    - Guardian Research Organization LLC
- Georgia
  - Peachtree City, Georgia, United States, 30269
    - Recruiting
    - Privia Medical Group Georgia LLC
- Idaho
  - Meridian, Idaho, United States, 83642
    - Recruiting
    - High Desert Heart and Vascular
- Illinois
  - Hazel Crest, Illinois, United States, 60429
    - Recruiting
    - Chicago Medical Research LLC
- Indiana
  - Elkhart, Indiana, United States, 46514
    - Recruiting
    - Midwest Cardiovascular Research and Education Foundation
  - Indianapolis, Indiana, United States, 46260
    - Recruiting
    - Ascension Medical Group
  - Munster, Indiana, United States, 46321
    - Recruiting
    - Cardiovascular Research of Northwest Indiana LLC
  - Richmond, Indiana, United States, 47374
    - Recruiting
    - Reid Physician Associates
- Kansas
  - Kansas City, Kansas, United States, 66160
    - Recruiting
    - University of Kansas Medical Center
  - Lenexa, Kansas, United States, 66219
    - Recruiting
    - Johnson County Clintrials
  - Wichita, Kansas, United States, 67214
    - Recruiting
    - Kansas Nephrology Research Institute LLC
- Kentucky
  - Lexington, Kentucky, United States, 40503
    - Recruiting
    - The Research Group of Lexington LLC
- Louisiana
  - Baton Rouge, Louisiana, United States, 70808
    - Recruiting
    - Our Lady of the Lake Medical Center
  - Covington, Louisiana, United States, 70433
    - Recruiting
    - Louisiana Heart Center - Hammond
  - Hammond, Louisiana, United States, 70403
    - Recruiting
    - Heart Clinic of Hammond
  - Mandeville, Louisiana, United States, 70448
    - Recruiting
    - Northshore Heart and Vascular LLC
- Maryland
  - Baltimore, Maryland, United States, 21287
    - Recruiting
    - Johns Hopkins University
  - Baltimore, Maryland, United States, 21229
    - Recruiting
    - Ascension Saint Agnes Heart Care
  - Beltsville, Maryland, United States, 20705
    - Recruiting
    - Metropolitan Cardiovascular Consultants Llc
  - Bowie, Maryland, United States, 20715
    - Recruiting
    - Flourish Bowie
- Michigan
  - Grand Rapids, Michigan, United States, 49546
    - Recruiting
    - Healthy Heart Cardiology
  - Rochester Hills, Michigan, United States, 48307
    - Recruiting
    - Advanced Cardiology Associates
- Minnesota
  - Maplewood, Minnesota, United States, 55109
    - Recruiting
    - Fairview Health Services M Health Fairview St Johns Hospital
  - Minneapolis, Minnesota, United States, 55455
    - Recruiting
    - University of Minnesota
- Missouri
  - Kansas City, Missouri, United States, 64111
    - Recruiting
    - Saint Luke's Hospital of Kansas City
- Montana
  - Kalispell, Montana, United States, 59901
    - Recruiting
    - Kalispell Regional Medical Center
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Recruiting
    - Bryan Heart
- New Jersey
  - Bridgewater, New Jersey, United States, 08807
    - Recruiting
    - Advanced Heart Care LLC
  - Marlton, New Jersey, United States, 08053
    - Recruiting
    - Virtua Health Incorporated
  - Newark, New Jersey, United States, 07102
    - Recruiting
    - Saint Michaels Medical Center
  - Somerset, New Jersey, United States, 08873
    - Recruiting
    - CardioMetabolic Collaborative Clinic
- New York
  - Albany, New York, United States, 12211
    - Recruiting
    - Capital Cardiology Associates
  - New York, New York, United States, 10019
    - Recruiting
    - Icahn School of Medicine at Mount Sinai
  - Poughkeepsie, New York, United States, 12601
    - Recruiting
    - Hudson Valley Cardiovascular Practice PC
  - Staten Island, New York, United States, 10310
    - Recruiting
    - Richmond University Medical Center
- North Carolina
  - Durham, North Carolina, United States, 27719
    - Recruiting
    - Duke University Health System
  - Wilmington, North Carolina, United States, 28401
    - Recruiting
    - Accellacare of Wilmington
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73135
    - Recruiting
    - South Oklahoma Heart Research
- Pennsylvania
  - Horsham, Pennsylvania, United States, 19044
    - Recruiting
    - Abington Medical Specialists
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Recruiting
    - Monument Health Clinical Research
- Tennessee
  - Jackson, Tennessee, United States, 38301
    - Recruiting
    - Apex Research Foundation, LLC
  - Jackson, Tennessee, United States, 38305
    - Recruiting
    - The Jackson Clinic PA
  - Oak Ridge, Tennessee, United States, 37830
    - Recruiting
    - Parkway Cardiology Associates
  - Powell, Tennessee, United States, 37849
    - Recruiting
    - Cardiovascular Research of Knoxville North Knoxville Medical Center
  - Tullahoma, Tennessee, United States, 37388
    - Recruiting
    - Tennessee Center For Clinical Trials
- Texas
  - Amarillo, Texas, United States, 79106
    - Recruiting
    - PharmaTex Research, LLC
  - Austin, Texas, United States, 78705
    - Recruiting
    - Austin Heart
  - Conroe, Texas, United States, 77384
    - Recruiting
    - Javara Research
  - Duncanville, Texas, United States, 75137
    - Recruiting
    - Dallas Heart and Vascular Consultants
  - El Paso, Texas, United States, 79905
    - Recruiting
    - David Turbay, MD
  - Houston, Texas, United States, 77043
    - Recruiting
    - Biopharma Informatic, LLC
  - Houston, Texas, United States, 77002
    - Recruiting
    - East Texas Cardiology PA
  - Houston, Texas, United States, 77084
    - Recruiting
    - Biopharma Informatic
  - Houston, Texas, United States, 77025
    - Recruiting
    - Biopharma Informatic
  - Humble, Texas, United States, 77338
    - Recruiting
    - Vital Heart and Vein
  - McKinney, Texas, United States, 75071
    - Recruiting
    - Texas Institute of Cardiology
  - McKinney, Texas, United States, 75069
    - Recruiting
    - North Dallas Research Associates
  - Sherman, Texas, United States, 75092
    - Recruiting
    - Sherman Clinical Research
  - Tomball, Texas, United States, 77375
    - Recruiting
    - Northwest Houston Clinical Research PLLC
- Virginia
  - Arlington, Virginia, United States, 22205
    - Recruiting
    - Conquest Research, LLC
  - Falls Church, Virginia, United States, 22042
    - Recruiting
    - Virginia Heart
  - Manassas, Virginia, United States, 20109
    - Recruiting
    - Carient Heart and Vascular
  - Roanoke, Virginia, United States, 24014
    - Recruiting
    - Roanoke Heart Institute PLC
  - Salem, Virginia, United States, 24153
    - Recruiting
    - Salem VA Medical Center
- Washington
  - Puyallup, Washington, United States, 98372
    - Recruiting
    - Pulse Heart Institute
- Wisconsin
  - Milwaukee, Wisconsin, United States, 53215
    - Recruiting
    - Advocate Aurora Saint Lukes Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Age ≥ 18 years at the time of informed consent.
BMI ≥ 30.0 kg/m^2 at the time of randomization.
HF diagnosed for at least 30 days with New York Heart Association (NYHA) Class II-IV at the time of informed consent.
Managed with HF standard of care therapies.
Left ventricular ejection fraction (LVEF) of > 40% within 12 months from the beginning of screening.
Elevated NT-proBNP.
Participants must have at least one of the following:
1. Structural heart disease within 12 months prior to screening OR
2. Documented hospitalization with a primary diagnosis of decompensated HF which required IV loop diuretic treatment > 30 days and < 12 months prior to randomization OR
3. Evidence of elevated filling pressures within 12 months before randomization.

Exclusion Criteria:

History of any of the following within 60 days prior to or during screening: Type I (spontaneous) MI, valvular replacement or repair, coronary revascularization, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke.
HF due to: hypertrophic cardiomyopathy, infiltrative cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, arrhythmogenic right ventricular or left ventricular cardiomyopathy/dysplasia, uncorrected primary valvular heart disease, clinically significant congenital heart disease.
Any lifetime history of LVEF ≤ 40%.
Hospitalized with acute decompensated HF at the time of or during the screening period.
Type 1 diabetes mellitus, or any type of diabetes with the exception of T2DM or history of gestational diabetes.
For participants with a prior diagnosis of T2DM (including those diagnosed during screening):
1. HbA1c > 10.0% (86 mmol/mol) at screening
2. Uncontrolled diabetes requiring immediate therapy
3. History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization
4. One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness
5. History or presence of either proliferative diabetic retinopathy, or diabetic maculopathy, or severe non-proliferative diabetic retinopathy; or currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema.
SBP ≥ 180 mmHg during the screening period, or on three or more blood pressure-lowering drugs with a SBP > 160 mmHg during the screening period.
History of chronic pancreatitis or acute pancreatitis in the 180 days before screening or during the screening period.
Any personal lifetime history of, or family history(first-degree relative[s]) of medullary thyroid carcinoma or MEN-2.
eGFR < 20 mL/min/1.73 m^2 (CKD-EPI creatinine (Cr)-cystatin C equation) or receiving dialysis at screening.
Calcitonin ≥ 50 ng/L (pg/mL) at screening.
Acute or chronic hepatitis.
Any of the following psychiatric history:
1. History of unstable major depressive disorder or other severe psychiatric disorder within 2 years prior to screening or during the screening period
2. Lifetime history of suicide attempt
3. History of non-suicidal self-injury within 5 years prior to screening or during the screening period.
History of any other condition that, in the opinion of the investigator, may preclude the participant from following the protocol and completing the trial.
Use of any glucagon-like peptide 1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) agonists or antagonists, or amylin analogs within 90 days prior to or during the screening period or planned use during the conduct of the trial.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Participants will receive placebo SC	Drug: Placebo Placebo will be administered SC.
Experimental: Maridebart Cafraglutide Participants will receive maridebart cafraglutide subcutaneously (SC)	Drug: Maridebart cafraglutide Maridebart cafraglutide will be administered SC. Other Names: AMG 133 MariTide

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events Time Frame: Up to approximately 35 months	Heart Failure events include: hospitalization for HF or urgent HF visits.	Up to approximately 35 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change From Baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score (CSS) for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Change from Baseline in the KCCQ Total Symptom Score (TSS) for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Total Number of HF Events Including First and Recurrent HF Events Time Frame: Up to approximately 35 months		Up to approximately 35 months
Time to First Event of a Composite Nephropathy Endpoint Time Frame: Up to approximately 35 months	The composite nephropathy endpoint consists of: persistent macroalbuminuria, persistent ≥ 40% reduction in estimated glomerular filtration rate (eGFR), onset of persistent eGFR < 15 mL/min/1.73 m^2, initiation of chronic renal replacement therapy (dialysis or transplantation), CV or renal death.	Up to approximately 35 months
Change in eGFR Slope (Total) Time Frame: Baseline up to approximately 35 months		Baseline up to approximately 35 months
Change in eGFR Slope (Chronic) Time Frame: From 4 months up to approximately 35 months		From 4 months up to approximately 35 months
Time to Onset of Type 2 Diabetes Mellitus (T2DM) in Participants with Prediabetes Time Frame: Up to approximately 35 months		Up to approximately 35 months
Time to the First HF Event Time Frame: Up to approximately 35 months		Up to approximately 35 months
Change from Baseline in the Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) Time Frame: Baseline and Week 72		Baseline and Week 72
Change from Baseline in the Waist Circumference (cm) Time Frame: Baseline and Week 72		Baseline and Week 72
Change from Baseline in the Urine Albumin-to-creatinine Ratio (uACR) Time Frame: Baseline and Week 72		Baseline and Week 72
Change from Baseline in the Hemoglobin A1c (HbA1c [%, mmol/mol]) in Participants with T2DM Time Frame: Baseline and Week 72		Baseline and Week 72
Percent Change from Baseline in the High-sensitivity C Reactive Protein (hs-CRP) Time Frame: Baseline and Week 72		Baseline and Week 72
Percent Change from Baseline in the Body Weight (kg) Time Frame: Baseline and Week 72		Baseline and Week 72
Percent Change from Baseline in Total Cholesterol Time Frame: Baseline and Week 72		Baseline and Week 72
Percent Change from Baseline in Non-high-density Lipoprotein Cholesterol (non-HDL-C) Time Frame: Baseline and Week 72		Baseline and Week 72
Percent Change from Baseline in Low-density Lipoprotein Cholesterol (LDL-C), HDL-C, Triglycerides (TG), Very Low-density Lipoprotein Cholesterol (VLDL-C) Time Frame: Baseline and Week 72		Baseline and Week 72
Total All-cause Hospitalizations (First and Recurrent Time to Event) Time Frame: Up to approximately 35 months		Up to approximately 35 months
Number of Participants Achieving ≥ 5-point Change in KCCQ-CSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Number of Participants Achieving ≥ 10-point Change in KCCQ-CSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Number of Participants Achieving an Anchor-based Change in KCCQ-CSS Score From Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The Patient Global Impression of Severity (PGI-S) and Patient Global Impression of Change (PGI-C) can be used as anchors to estimate within-patient change in the KCCQ-CSS score.	Baseline and Week 48
Number of Participants Achieving ≥ 5-point Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Number of Participants Achieving ≥ 10-point Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life.	Baseline and Week 48
Number of Participants Achieving an Anchor-based Change in KCCQ-TSS Score from Baseline for Participants with Baseline KCCQ-CSS Score ≤ 80 Time Frame: Baseline and Week 48	The KCCQ is a 23-item disease-specific measure for participants with HF, measuring the participant's perception of their health status. The KCCQ-TSS assesses symptom frequency and burden, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The KCCQ-CSS assesses symptoms and physical limitations, ranging from 0 to 100, with higher scores indicating better functioning and quality of life. The PGI-S and PGI-C can be used as anchors to estimate within-patient change in the KCCQ-CSS score.	Baseline and Week 48
Time to All-cause Death Time Frame: Up to approximately 35 months		Up to approximately 35 months
Time to CV Death Time Frame: Up to Approximately 35 Months		Up to Approximately 35 Months
Number of Participants with Treatment-emergent Adverse Events and Serious Adverse Events Time Frame: Up to approximately 35 months		Up to approximately 35 months
Plasma Concentration of Maridebart Cafraglutide Time Frame: Week 72		Week 72
Change from Baseline in N-terminal Pro B Type Natriuretic Peptide (NT-proBNP) Time Frame: Baseline and Week 72		Baseline and Week 72
Time to New Onset of Atrial Fibrillation (AF) or Atrial Flutter (AFL) in Participants Without a History of AF or AFL at Baseline Time Frame: Baseline and up to approximately 35 months		Baseline and up to approximately 35 months
Time to First Occurrence of a Composite Endpoint Consisting of: Myocardial Infarction (MI), Ischemic Stroke, CV Death (Major Adverse Cardiac Events [MACE]), or HF Events Time Frame: Up to approximately 35 months		Up to approximately 35 months
Change from Baseline in Body Mass Index (BMI) (kg/m^2) Time Frame: Baseline and Week 72		Baseline and Week 72

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Amgen

Investigators

Study Director: MD, Amgen

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

AmgenTrials clinical trials website

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 25, 2025

Primary Completion (Estimated)

June 30, 2028

Study Completion (Estimated)

September 29, 2030

Study Registration Dates

First Submitted

June 16, 2025

First Submitted That Met QC Criteria

June 16, 2025

First Posted (Actual)

June 25, 2025

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 20, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

20230227

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

IPD Sharing Time Frame

Data sharing requests relating to this trial will be considered beginning 18 months after the trial has ended and either 1) the product and indication have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this trial.

IPD Sharing Access Criteria

Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen trial/trials in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors. If not approved, a Data Sharing Independent Review Panel will arbitrate and make the final decision. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
ICF
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

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Clinical Trials on Placebo

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