Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease (ZENITH)

May 12, 2026 updated by: Alnylam Pharmaceuticals

ZENITH: A Phase 3 Global, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Zilebesiran in Addition to Standard of Care in Reducing Major Adverse Cardiovascular Events in Adult Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

11000

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Clinical Trial Information Line
Phone Number: 1-877-ALNYLAM
Email: clinicaltrials@alnylam.com

Study Contact Backup

Name: Clinical Trial Information Line
Phone Number: 1-877-256-9526
Email: clinicaltrials@alnylam.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1012AAR
    - Recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1060ABN
    - Recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1128AAF
    - Recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1205EYG
    - Recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1405BCH
    - Recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1425AGC
    - Not yet recruiting
    - Clinical Trial Site
  - Buenos Aires, Argentina, C1430CKE
    - Not yet recruiting
    - Clinical Trial Site
  - Córdoba, Argentina, X5000AAW
    - Recruiting
    - Clinical Trial Site
  - Córdoba, Argentina, X5003DCE
    - Not yet recruiting
    - Clinical Trial Site
  - Córdoba, Argentina, X5006CBI
    - Recruiting
    - Clinical Trial Site
  - Córdoba, Argentina, X5006ICG
    - Not yet recruiting
    - Clinical Trial Site
  - Córdoba, Argentina, X5016KET
    - Recruiting
    - Clinical Trial Site
  - Formosa, Argentina, P3600KGC
    - Not yet recruiting
    - Clinical Trial Site
  - Rosario, Argentina, S2000DEJ
    - Not yet recruiting
    - Clinical Trial Site
  - Rosario, Argentina, S2000DTP
    - Recruiting
    - Clinical Trial Site
Australia
- - Auchenflower, Australia, 4066
    - Not yet recruiting
    - Clinical Trial Site
  - Brookvale, Australia, 2100
    - Recruiting
    - Clinical Trial Site
  - Castle Hill, Australia, 2154
    - Recruiting
    - Clinical Trial Site
  - Clayton, Australia, 3168
    - Not yet recruiting
    - Clinical Trial Site
  - Concord, Australia, 2139
    - Not yet recruiting
    - Clinical Trial Site
  - Gosford, Australia, 2250
    - Recruiting
    - Clinical Trial Site
  - Kogarah, Australia, 2217
    - Not yet recruiting
    - Clinical Trial Site
  - Leabrook, Australia, 5068
    - Not yet recruiting
    - Clinical Trial Site
  - Merewether, Australia, 2291
    - Not yet recruiting
    - Clinical Trial Site
  - Milton, Australia, 4064
    - Not yet recruiting
    - Clinical Trial Site
  - Sippy Downs, Australia, 4556
    - Recruiting
    - Clinical Trial Site
  - Southport, Australia, 4217
    - Recruiting
    - Clinical Trial Site
  - Tarragindi, Australia, 4121
    - Not yet recruiting
    - Clinical Trial Site
  - Waitara, Australia, 2077
    - Recruiting
    - Clinical Trial Site
Austria
- - Braunau am Inn, Austria, 5280
    - Recruiting
    - Clinical Trial Site
  - Graz, Austria, 8036
    - Recruiting
    - Clinical Trial Site
  - Saint Stefan Ob Stainz, Austria, 8511
    - Recruiting
    - Clinical Trial Site
  - Vienna, Austria, 1060
    - Recruiting
    - Clinical Trial Site
  - Vienna, Austria, 1190
    - Recruiting
    - Clinical Trial Site
  - Vienna, Austria, 1210
    - Not yet recruiting
    - Clinical Trial Site
Belgium
- - Aalst, Belgium, 9300
    - Not yet recruiting
    - Clinical Trial Site
  - Bonheiden, Belgium, 2820
    - Not yet recruiting
    - Clinical Trial Site
  - Brasschaat, Belgium, 2930
    - Not yet recruiting
    - Clinical Trial Site
  - Brussels, Belgium, 1000
    - Not yet recruiting
    - Clinical Trial Site
  - Erpent, Belgium, 5101
    - Not yet recruiting
    - Clinical Trial Site
  - Genk, Belgium, 3600
    - Not yet recruiting
    - Clinical Trial Site
  - Ghent, Belgium, 9000
    - Not yet recruiting
    - Clinical Trial Site
  - Hasselt, Belgium, 3500
    - Not yet recruiting
    - Clinical Trial Site
  - Huy, Belgium, 4500
    - Not yet recruiting
    - Clinical Trial Site
  - Ieper, Belgium, 8900
    - Not yet recruiting
    - Clinical Trial Site
  - Kortrijk, Belgium, 8500
    - Recruiting
    - Clinical Trial Site
  - Leuven, Belgium, 3000
    - Recruiting
    - Clinical Trial Site
  - Liège, Belgium, 4000
    - Recruiting
    - Clinical Trial Site
  - Ronse, Belgium, 9600
    - Not yet recruiting
    - Clinical Trial Site
  - Yvoir, Belgium, 5530
    - Not yet recruiting
    - Clinical Trial Site
Brazil
- - Aracaju, Brazil, 49055-210
    - Not yet recruiting
    - Clinical Trial Site
  - Belo Horizonte, Brazil, 30150-320
    - Not yet recruiting
    - Clinical Trial Site
  - Curitiba, Brazil, 80030-480
    - Not yet recruiting
    - Clinical Trial Site
  - Fortaleza, Brazil, 60160-230
    - Not yet recruiting
    - Clinical Trial Site
  - Fortaleza, Brazil, 60430-350
    - Not yet recruiting
    - Clinical Trial Site
  - Joinville, Brazil, 89227-680
    - Not yet recruiting
    - Clinical Trial Site
  - Porto Alegre, Brazil, 90430-001
    - Not yet recruiting
    - Clinical Trial Site
  - Porto Alegre, Brazil, 90560-032
    - Not yet recruiting
    - Clinical Trial Site
  - Porto Alegre, Brazil, 90610-000
    - Not yet recruiting
    - Clinical Trial Site
  - Rio de Janeiro, Brazil, 20241-180
    - Recruiting
    - Clinical Trial Site
  - Salvador, Brazil, 40301-155
    - Recruiting
    - Clinical Trial Site
  - São José do Rio Preto, Brazil, 15090-000
    - Recruiting
    - Clinical Trial Site
  - São José dos Campos, Brazil, 12243-280
    - Not yet recruiting
    - Clinical Trial Site
  - São Paulo, Brazil, 01228-000
    - Not yet recruiting
    - Clinical Trial Site
Bulgaria
- - Blagoevgrad, Bulgaria, 2700
    - Not yet recruiting
    - Clinical Trial Site
  - Burgas, Bulgaria, 8000
    - Recruiting
    - Clinical Trial Site
  - Burgas, Bulgaria, 8008
    - Recruiting
    - Clinical Trial Site
  - Burgas, Bulgaria, 8000
    - Not yet recruiting
    - Clinical Trial Site
  - Dimitrovgrad, Bulgaria, 6400
    - Recruiting
    - Clinical Trial Site
  - Haskovo, Bulgaria, 6300
    - Not yet recruiting
    - Clinical Trial Site
  - Pleven, Bulgaria, 5800
    - Recruiting
    - Clinical Trial Site
  - Rousse, Bulgaria, 7003
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1510
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1431
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1680
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1000
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1404
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1700
    - Not yet recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1756
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1574
    - Recruiting
    - Clinical Trial Site
  - Sofia, Bulgaria, 1582
    - Not yet recruiting
    - Clinical Trial Site
  - Stara Zagora, Bulgaria, 6000
    - Recruiting
    - Clinical Trial Site
  - Veliko Tarnovo, Bulgaria, 5006
    - Recruiting
    - Clinical Trial Site
Canada
- - Brampton, Canada, L6Z 4N5
    - Recruiting
    - Clinical Trial Site
  - Brampton, Canada, L6S 0C6
    - Not yet recruiting
    - Clinical Trial Site
  - Burlington, Canada, L7M 1K9
    - Not yet recruiting
    - Clinical Trial Site
  - Cambridge, Canada, N1R 7R1
    - Not yet recruiting
    - Clinical Trial Site
  - Chicoutimi, Canada, G7H 7K9
    - Not yet recruiting
    - Clinical Trial Site
  - Etobicoke, Canada, M9R 4E1
    - Recruiting
    - Clinical Trial Site
  - Greater Sudbury, Canada, P3C 1S8
    - Not yet recruiting
    - Clinical Trial Site
  - Laval, Canada, H7T 2P5
    - Recruiting
    - Clinical Trial Site
  - London, Canada, N6A 5W9
    - Not yet recruiting
    - Clinical Trial Site
  - Longueuil, Canada, J4H 4B9
    - Recruiting
    - Clinical Trial Site
  - Lévis, Canada, G6W 0M5
    - Recruiting
    - Clinical Trial Site
  - Mirabel, Canada, J7J 2K8
    - Recruiting
    - Clinical Trial Site
  - Mississauga, Canada, L5K 2L3
    - Recruiting
    - Clinical Trial Site
  - Moncton, Canada, E1G 5C4
    - Recruiting
    - Clinical Trial Site
  - Montreal, Canada, H1M 1B1
    - Not yet recruiting
    - Clinical Trial Site
  - Montreal, Canada, H1M 1L3
    - Not yet recruiting
    - Clinical Trial Site
  - Peterborough, Canada, K9J 0B2
    - Not yet recruiting
    - Clinical Trial Site
  - Québec, Canada, G1R 2J6
    - Recruiting
    - Clinical Trial Site
  - Sarnia, Canada, N7T 4X3
    - Not yet recruiting
    - Clinical Trial Site
  - Scarborough, Canada, M1B 4Z8
    - Recruiting
    - Clinical Trial Site
  - Scarborough, Canada, M1B 5N1
    - Not yet recruiting
    - Clinical Trial Site
  - Sherbrooke, Canada, 8193462887
    - Recruiting
    - Clinical Trial Site
  - Sydney, Canada, B1S 0K1
    - Recruiting
    - Clinical Trial Site
  - Toronto, Canada, M6N 1B5
    - Recruiting
    - Clinical Trial Site
  - Trois-Rivières, Canada, G9A 4P3
    - Not yet recruiting
    - Clinical Trial Site
Chile
- - Independencia, Chile, 8380000
    - Recruiting
    - Clinical Trial Site
  - Santiago, Chile, 7500588
    - Recruiting
    - Clinical Trial Site
  - Santiago, Chile, 7500739
    - Not yet recruiting
    - Clinical Trial Site
  - Santiago, Chile, 7770086
    - Recruiting
    - Clinical Trial Site
  - Santiago, Chile, 8900085
    - Recruiting
    - Clinical Trial Site
  - Valdivia, Chile, 5110683
    - Recruiting
    - Clinical Trial Site
China
- - Luoyang, China, 471002
    - Not yet recruiting
    - Clinical Trial Site
  - Shanghai, China, 200032
    - Not yet recruiting
    - Clinical Trial Site
Czechia
- - Brno, Czechia, 612 00
    - Not yet recruiting
    - Clinical Trial Site
  - Brno, Czechia, 602 00
    - Recruiting
    - Clinical Trial Site
  - Bílina, Czechia, 418 01
    - Not yet recruiting
    - Clinical Trial Site
  - Chlumec nad Cidlinou, Czechia, 503 51
    - Recruiting
    - Clinical Trial Site
  - Hodonín, Czechia, 695 01
    - Not yet recruiting
    - Clinical Trial Site
  - Krnov, Czechia, 794 01
    - Recruiting
    - Clinical Trial Site
  - Mariánské Lázně, Czechia, 353 01
    - Recruiting
    - Clinical Trial Site
  - Olomouc, Czechia, 779 00
    - Recruiting
    - Clinical Trial Site
  - Ostrava, Czechia, 702 00
    - Recruiting
    - Clinical Trial Site
  - Ostrava, Czechia, 708-52
    - Recruiting
    - Clinical Trial Site
  - Ostrava, Czechia, 700 30
    - Recruiting
    - Clinical Trial Site
  - Pardubice, Czechia, 532 03
    - Recruiting
    - Clinical Trial Site
  - Prague, Czechia, 101 00
    - Not yet recruiting
    - Clinical Trial Site
  - Prague, Czechia, 120 00
    - Recruiting
    - Clinical Trial Site
  - Prague, Czechia, 140 59
    - Not yet recruiting
    - Clinical Trial Site
  - Příbram, Czechia, 261 01
    - Recruiting
    - Clinical Trial Site
  - Slaný, Czechia, 274 01
    - Recruiting
    - Clinical Trial Site
  - Zlín, Czechia, 760 01
    - Recruiting
    - Clinical Trial Site
Denmark
- - København S, Denmark, 02300
    - Not yet recruiting
    - Clinical Trial Site
France
- - Auxerre, France, 89000
    - Recruiting
    - Clinical Trial Site
  - Bobigny, France, 93000
    - Not yet recruiting
    - Clinical Trial Site
  - Nîmes, France, 30900
    - Not yet recruiting
    - Clinical Trial Site
  - Paris, France, 75010
    - Not yet recruiting
    - Clinical Trial Site
  - Pau, France, 64046
    - Not yet recruiting
    - Clinical Trial Site
  - Poitiers, France, 86000
    - Not yet recruiting
    - Clinical Trial Site
  - Saint-Herblain, France, 44093
    - Not yet recruiting
    - Clinical Trial Site
  - Valenciennes, France, 59300
    - Not yet recruiting
    - Clinical Trial Site
Germany
- - Ahaus, Germany, 48683
    - Not yet recruiting
    - Clinical Trial Site
  - Altenburg, Germany, 04600
    - Recruiting
    - Clinical Trial Site
  - Bad Homburg, Germany, 61348
    - Recruiting
    - Clinical Trial Site
  - Berlin, Germany, 10789
    - Recruiting
    - Clinical Trial Site
  - Berlin, Germany, 13347
    - Recruiting
    - Clinical Trial Site
  - Berlin, Germany, 10629
    - Recruiting
    - Clinical Trial Site
  - Berlin, Germany, 12203
    - Not yet recruiting
    - Clinical Trial Site
  - Bremen, Germany, 28277
    - Not yet recruiting
    - Clinical Trial Site
  - Cologne, Germany, 51069
    - Recruiting
    - Clinical Trial Site
  - Dortmund, Germany, 44137
    - Recruiting
    - Clinical Trial Site
  - Dresden, Germany, 01099
    - Recruiting
    - Clinical Trial Site
  - Elsterwerda, Germany, 04910
    - Recruiting
    - Clinical Trial Site
  - Essen, Germany, 45355
    - Not yet recruiting
    - Clinical Trial Site
  - Frankfurt am Main, Germany, 60590
    - Not yet recruiting
    - Clinical Trial Site
  - Hamburg, Germany, 22763
    - Not yet recruiting
    - Clinical Trial Site
  - Jerichow, Germany, 39319
    - Not yet recruiting
    - Clinical Trial Site
  - Kaiserslautern, Germany, 67655
    - Not yet recruiting
    - Clinical Trial Site
  - Langen, Germany, 63225
    - Not yet recruiting
    - Clinical Trial Site
  - Leipzig, Germany, 04289
    - Not yet recruiting
    - Clinical Trial Site
  - Mühldorf, Germany, 84453
    - Recruiting
    - Clinical Trial Site
  - Offenbach, Germany, 63065
    - Recruiting
    - Clinical Trial Site
  - Papenburg, Germany, 26871
    - Recruiting
    - Clinical Trial Site
  - Pirna, Germany, 01796
    - Recruiting
    - Clinical Trial Site
  - Stuhr, Germany, 28816
    - Recruiting
    - Clinical Trial Site
  - Villingen-Schwenningen, Germany, 78052
    - Not yet recruiting
    - Clinical Trial Site
  - Wermsdorf, Germany, 04779
    - Not yet recruiting
    - Clinical Trial Site
  - Zwenkau, Germany, 04442
    - Not yet recruiting
    - Clinical Trial Site
Greece
- - Ampelokipoi, Greece, 115 26
    - Not yet recruiting
    - Clinical Trial Site
  - Athens, Greece, 115 27
    - Recruiting
    - Clinical Trial Site
  - Athens, Greece, 115 27
    - Not yet recruiting
    - Clinical Trial Site
  - Athens, Greece, 115 21
    - Recruiting
    - Clinical Trial Site
  - Chios, Greece, 82131
    - Recruiting
    - Clinical Trial Site
  - Heraklion, Greece, 714 09
    - Not yet recruiting
    - Clinical Trial Site
  - Heraklion, Greece, 715 00
    - Not yet recruiting
    - Clinical Trial Site
  - Ioannina, Greece, 454 45
    - Recruiting
    - Clinical Trial Site
  - Kalyftaki-N. Kifissia, Greece, 145 64
    - Not yet recruiting
    - Clinical Trial Site
  - Kifissia, Greece, 145 61
    - Recruiting
    - Clinical Trial Site
  - Larissa, Greece, 411 10
    - Not yet recruiting
    - Clinical Trial Site
  - Marousi, Greece, 151 23
    - Not yet recruiting
    - Clinical Trial Site
  - N. Efkapria-Pavlos Melas, Greece, 564 03
    - Recruiting
    - Clinical Trial Site
  - Nea Ionia, Greece, 142 33
    - Not yet recruiting
    - Clinical Trial Site
  - Nikaia, Greece, 184 54
    - Recruiting
    - Clinical Trial Site
  - Pylaia, Greece, 570 01
    - Not yet recruiting
    - Clinical Trial Site
  - Pátrai, Greece, 265 04
    - Recruiting
    - Clinical Trial Site
  - Thessaloniki, Greece, 546 42
    - Recruiting
    - Clinical Trial Site
  - Thessaloniki, Greece, 546 36
    - Not yet recruiting
    - Clinical Trial Site
  - Thessaloniki, Greece, 546 42
    - Not yet recruiting
    - Clinical Trial Site
  - Voula, Greece, 166 73
    - Recruiting
    - Clinical Trial Site
Hungary
- - Baja, Hungary, 6500
    - Recruiting
    - Clinical Trial Site
  - Balatonfüred, Hungary, 8230
    - Recruiting
    - Clinical Trial Site
  - Budapest, Hungary, 1033
    - Not yet recruiting
    - Clinical Trial Site
  - Békéscsaba, Hungary, 5600
    - Recruiting
    - Clinical Trial Site
  - Gyöngyös, Hungary, 3200
    - Not yet recruiting
    - Clinical Trial Site
  - Hódmezovásárhely, Hungary, 6800
    - Not yet recruiting
    - Clinical Trial Site
  - Nyíregyháza, Hungary, 4400
    - Recruiting
    - Clinical Trial Site
  - Nyíregyháza, Hungary, 4405
    - Not yet recruiting
    - Clinical Trial Site
  - Orosháza, Hungary, 5905
    - Not yet recruiting
    - Clinical Trial Site
  - Szeged, Hungary, 6724
    - Not yet recruiting
    - Clinical Trial Site
  - Zalaegerszeg, Hungary, 8900
    - Not yet recruiting
    - Clinical Trial Site
Italy
- - Ancona, Italy, 60129
    - Recruiting
    - Clinical Trial Site
  - L’Aquila, Italy, 67100
    - Not yet recruiting
    - Clinical Trial Site
  - Messina, Italy, 98125
    - Not yet recruiting
    - Clinical Trial Site
  - Naples, Italy, 80131
    - Recruiting
    - Clinical Trial Site
  - Novara, Italy, 28100
    - Not yet recruiting
    - Clinical Trial Site
  - Palermo, Italy, 90127
    - Recruiting
    - Clinical Trial Site
  - Pisa, Italy, 56124
    - Not yet recruiting
    - Clinical Trial Site
  - Pozzilli, Italy, 86077
    - Not yet recruiting
    - Clinical Trial Site
  - San Benedetto del Tronto, Italy, 63074
    - Not yet recruiting
    - Clinical Trial Site
  - Terni, Italy, 5100
    - Not yet recruiting
    - Clinical Trial Site
Japan
- - Bunkyō City, Japan, 113-8603
    - Not yet recruiting
    - Clinical Trial Site
  - Chikushino-shi, Japan, 818-0058
    - Recruiting
    - Clinical Trial Site
  - Chūōku, Japan, 103-0027
    - Recruiting
    - Clinical Trial Site
  - Chūōku, Japan, 810-0066
    - Recruiting
    - Clinical Trial Site
  - Chūōku, Japan, 104-0044
    - Recruiting
    - Clinical Trial Site
  - Fukuoka, Japan, 812-8582
    - Not yet recruiting
    - Clinical Trial Site
  - Fukuoka, Japan, 814-0180
    - Recruiting
    - Clinical Trial Site
  - Hachioji-Shi, Japan, 192-0918
    - Not yet recruiting
    - Clinical Trial Site
  - Hachiōji, Japan, 193-0811
    - Recruiting
    - Clinical Trial Site
  - Hakodate-Shi, Japan, 041-0821
    - Not yet recruiting
    - Clinical Trial Site
  - Hakodate-Shi, Japan, 040-8611
    - Not yet recruiting
    - Clinical Trial Site
  - Himeji, Japan, 670-8560
    - Recruiting
    - Clinical Trial Site
  - Izumi, Japan, 594-0073
    - Recruiting
    - Clinical Trial Site
  - Kasuga, Japan, 816-0864
    - Recruiting
    - Clinical Trial Site
  - Kita-ku, Japan, 530-0052
    - Recruiting
    - Clinical Trial Site
  - Kusatsu, Japan, 525-8585
    - Recruiting
    - Clinical Trial Site
  - Minamiku, Japan, 861-4193
    - Not yet recruiting
    - Clinical Trial Site
  - Minato, Japan, 108-0073
    - Recruiting
    - Clinical Trial Site
  - Nagaoka-Shi, Japan, 940-8621
    - Recruiting
    - Clinical Trial Site
  - Nagasaki, Japan, 850-0842
    - Recruiting
    - Clinical Trial Site
  - Okayama, Japan, 700-0804
    - Recruiting
    - Clinical Trial Site
  - Osaka, Japan, 530-0012
    - Not yet recruiting
    - Clinical Trial Site
  - Osaka, Japan, 558-8558
    - Recruiting
    - Clinical Trial Site
  - Osaka, Japan, 530-0005
    - Recruiting
    - Clinical Trial Site
  - Osaka, Japan, 532-0025
    - Recruiting
    - Clinical Trial Site
  - Saku, Japan, 385-0051
    - Not yet recruiting
    - Clinical Trial Site
  - Sakura-Shi, Japan, 285-0841
    - Not yet recruiting
    - Clinical Trial Site
  - Sapporo, Japan, 003-0026
    - Not yet recruiting
    - Clinical Trial Site
  - Sapporo, Japan, 062-8618
    - Recruiting
    - Clinical Trial Site
  - Sendai, Japan, 983-0039
    - Recruiting
    - Clinical Trial Site
  - Shimotsuke-shi, Japan, 329-0498
    - Not yet recruiting
    - Clinical Trial Site
  - Shinagawa-Ku, Japan, 140-8522
    - Recruiting
    - Clinical Trial Site
  - Shinjuku-ku, Japan, 162-8666
    - Not yet recruiting
    - Clinical Trial Site
  - Suita, Japan, 565-0871
    - Not yet recruiting
    - Clinical Trial Site
  - Tamanashi, Japan, 865-0016
    - Recruiting
    - Clinical Trial Site
  - Yokohama, Japan, 236-0004
    - Not yet recruiting
    - Clinical Trial Site
  - Yokosuka, Japan, 239-8567
    - Recruiting
    - Clinical Trial Site
  - Ōta-ku, Japan, 144-0051
    - Not yet recruiting
    - Clinical Trial Site
Netherlands
- - 's-Hertogenbosch, Netherlands, 5223 GZ
    - Recruiting
    - Clinical Trial Site
  - Amersfoort, Netherlands, 3813 TZ
    - Recruiting
    - Clinical Trial Site
  - Ede, Netherlands, 6716 RP
    - Not yet recruiting
    - Clinical Trial Site
  - Goes, Netherlands, 4462 RA
    - Not yet recruiting
    - Clinical Trial Site
  - Hoogeveen, Netherlands, 7909 AA
    - Not yet recruiting
    - Clinical Trial Site
  - Hoorn, Netherlands, 1624 NP
    - Not yet recruiting
    - Clinical Trial Site
  - Utrecht, Netherlands, 3584 CX
    - Not yet recruiting
    - Clinical Trial Site
New Zealand
- - Auckland, New Zealand, 1023
    - Not yet recruiting
    - Clinical Trial Site
  - Christchurch, New Zealand, 8011
    - Not yet recruiting
    - Clinical Trial Site
  - Ebdentown, New Zealand, 5018
    - Recruiting
    - Clinical Trial Site
  - Hamilton, New Zealand, 3243
    - Recruiting
    - Clinical Trial Site
  - Silverdale, New Zealand, 0932
    - Recruiting
    - Clinical Trial Site
  - Takapuna, New Zealand, 0620
    - Not yet recruiting
    - Clinical Trial Site
  - Wellington, New Zealand, 6021
    - Not yet recruiting
    - Clinical Trial Site
Poland
- - Bydgoszcz, Poland, 85-092
    - Recruiting
    - Clinical Trial Site
  - Bydgoszcz, Poland, 85-605
    - Recruiting
    - Clinical Trial Site
  - Chrzanów, Poland, 32-500
    - Recruiting
    - Clinical Trial Site
  - Częstochowa, Poland, 42-202
    - Recruiting
    - Clinical Trial Site
  - Dębica, Poland, 39-200
    - Recruiting
    - Clinical Trial Site
  - Gdansk, Poland, 80-262
    - Recruiting
    - Clinical Trial Site
  - Gdansk, Poland, 80-382
    - Recruiting
    - Clinical Trial Site
  - Gdynia, Poland, 81-157
    - Recruiting
    - Clinical Trial Site
  - Giżycko, Poland, 11-500
    - Recruiting
    - Clinical Trial Site
  - Jaksice, Poland, 88-181
    - Not yet recruiting
    - Clinical Trial Site
  - Katowice, Poland, 40-040
    - Recruiting
    - Clinical Trial Site
  - Katowice, Poland, 40-156
    - Recruiting
    - Clinical Trial Site
  - Katowice, Poland, 40-555
    - Not yet recruiting
    - Clinical Trial Site
  - Katowice, Poland, 40-648
    - Recruiting
    - Clinical Trial Site
  - Katowice, Poland, 40-760
    - Not yet recruiting
    - Clinical Trial Site
  - Krakow, Poland, 31-501
    - Recruiting
    - Clinical Trial Site
  - Krakow, Poland, 31-721
    - Recruiting
    - Clinical Trial Site
  - Kędzierzyn-Koźle, Poland, 47-200
    - Not yet recruiting
    - Clinical Trial Site
  - Lodz, Poland, 90-127
    - Recruiting
    - Clinical Trial Site
  - Lodz, Poland, 90-302
    - Recruiting
    - Clinical Trial Site
  - Lodz, Poland, 91-363
    - Recruiting
    - Clinical Trial Site
  - Lublin, Poland, 20-068
    - Recruiting
    - Clinical Trial Site
  - Lublin, Poland, 20-412
    - Recruiting
    - Clinical Trial Site
  - Myszków, Poland, 42-300
    - Recruiting
    - Clinical Trial Site
  - Olsztyn, Poland, 10-165
    - Recruiting
    - Clinical Trial Site
  - Ostrowiec Świętokrzyski, Poland, 27-400
    - Recruiting
    - Clinical Trial Site
  - Piotrkow Trybunalski, Poland, 97-300
    - Recruiting
    - Clinical Trial Site
  - Poznan, Poland, 60-111
    - Recruiting
    - Clinical Trial Site
  - Ruda Śląska, Poland, 41-710
    - Recruiting
    - Clinical Trial Site
  - Rybnik, Poland, 44-203
    - Not yet recruiting
    - Clinical Trial Site
  - Rzeszów, Poland, 35-055
    - Not yet recruiting
    - Clinical Trial Site
  - Siedlce, Poland, 08-110
    - Recruiting
    - Clinical Trial Site
  - Skierniewice, Poland, 96-100
    - Not yet recruiting
    - Clinical Trial Site
  - Sopot, Poland, 81-717
    - Recruiting
    - Clinical Trial Site
  - Staszów, Poland, 28-200
    - Recruiting
    - Clinical Trial Site
  - Tarnów, Poland, 33-100
    - Not yet recruiting
    - Clinical Trial Site
  - Torun, Poland, 87-100
    - Not yet recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 01-249
    - Recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 02-677
    - Not yet recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 02-696
    - Recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 02-758
    - Recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 02-097
    - Not yet recruiting
    - Clinical Trial Site
  - Warsaw, Poland, 02-672
    - Recruiting
    - Clinical Trial Site
  - Wroclaw, Poland, 53-034
    - Not yet recruiting
    - Clinical Trial Site
  - Zamość, Poland, 22-400
    - Recruiting
    - Clinical Trial Site
  - Świdnik, Poland, 21-040
    - Recruiting
    - Clinical Trial Site
Portugal
- - Baixa Da Banheira, Portugal, 2835-127
    - Recruiting
    - Clinical Trial Site
  - Carnaxide, Portugal, 2790-134
    - Not yet recruiting
    - Clinical Trial Site
  - Coimbra, Portugal, 3004-561
    - Not yet recruiting
    - Clinical Trial Site
  - Coimbra, Portugal, 3000-150
    - Recruiting
    - Clinical Trial Site
  - Creixomil, Portugal, 4835-044
    - Not yet recruiting
    - Clinical Trial Site
  - Leiria, Portugal, 2400-110
    - Recruiting
    - Clinical Trial Site
  - Lisbon, Portugal, 1500-048
    - Recruiting
    - Clinical Trial Site
  - Loures, Portugal, 2674-514
    - Recruiting
    - Clinical Trial Site
  - Ponte de Lima, Portugal, 4990-029
    - Recruiting
    - Clinical Trial Site
  - Riachos, Portugal, 2350-325
    - Recruiting
    - Clinical Trial Site
  - Santa Maria da Feira, Portugal, 4520-211
    - Not yet recruiting
    - Clinical Trial Site
  - Senhora da Hora, Portugal, 4464-513
    - Recruiting
    - Clinical Trial Site
Romania
- - Baia Mare, Romania, 430124
    - Recruiting
    - Clinical Trial Site
  - Baia Mare, Romania, 430222
    - Recruiting
    - Clinical Trial Site
  - Brasov, Romania, 500091
    - Not yet recruiting
    - Clinical Trial Site
  - Brasov, Romania, 500283
    - Not yet recruiting
    - Clinical Trial Site
  - Bucharest, Romania, 021875
    - Recruiting
    - Clinical Trial Site
  - Bucharest, Romania, 022328
    - Recruiting
    - Clinical Trial Site
  - Iași, Romania, 700503
    - Not yet recruiting
    - Clinical Trial Site
  - Iași, Romania, 700547
    - Not yet recruiting
    - Clinical Trial Site
  - Oradea, Romania, 410469
    - Recruiting
    - Clinical Trial Site
  - Ploieşti, Romania, 100342
    - Recruiting
    - Clinical Trial Site
  - Satu Mare, Romania, 440192
    - Not yet recruiting
    - Clinical Trial Site
  - Sibiu, Romania, 550371
    - Not yet recruiting
    - Clinical Trial Site
  - Timișoara, Romania, 300362
    - Recruiting
    - Clinical Trial Site
  - Timișoara, Romania, 300024
    - Not yet recruiting
    - Clinical Trial Site
  - Târgu Mureş, Romania, 540136
    - Recruiting
    - Clinical Trial Site
Serbia
- - Belgrade, Serbia, 11000
    - Not yet recruiting
    - Clinical Trial Site
  - Zaječar, Serbia, 19000
    - Not yet recruiting
    - Clinical Trial Site
Slovakia
- - Bardejov, Slovakia, 085 01
    - Recruiting
    - Clinical Trial Site
  - Bratislava, Slovakia, 831 03
    - Recruiting
    - Clinical Trial Site
  - Bratislava, Slovakia, 833 05
    - Not yet recruiting
    - Clinical Trial Site
  - Bratislava, Slovakia, 841 03
    - Recruiting
    - Clinical Trial Site
  - Brezno, Slovakia, 977 01
    - Recruiting
    - Clinical Trial Site
  - Ilava, Slovakia, 019 01
    - Recruiting
    - Clinical Trial Site
  - Košice, Slovakia, 040 01
    - Recruiting
    - Clinical Trial Site
  - Košice, Slovakia, 040 22
    - Recruiting
    - Clinical Trial Site
  - Lučenec, Slovakia, 984 01
    - Not yet recruiting
    - Clinical Trial Site
  - Moldava nad Bodvou, Slovakia, 045 01
    - Recruiting
    - Clinical Trial Site
  - Nitra, Slovakia, 949 01
    - Recruiting
    - Clinical Trial Site
  - Nitra, Slovakia, 949 01
    - Not yet recruiting
    - Clinical Trial Site
  - Prešov, Slovakia, 080 01
    - Recruiting
    - Clinical Trial Site
  - Stará Turá, Slovakia, 916 01
    - Recruiting
    - Clinical Trial Site
  - Vinica, Slovakia, 991 28
    - Not yet recruiting
    - Clinical Trial Site
South Africa
- - Belville, South Africa, 7530
    - Recruiting
    - Clinical Trial Site
  - Bloemfontein, South Africa, 9301
    - Not yet recruiting
    - Clinical Trial Site
  - Bloemfontein, South Africa, 9321
    - Recruiting
    - Clinical Trial Site
  - Cape Town, South Africa, 7130
    - Recruiting
    - Clinical Trial Site
  - Cape Town, South Africa, 7500
    - Recruiting
    - Clinical Trial Site
  - Cape Town, South Africa, 7646
    - Recruiting
    - Clinical Trial Site
  - Chatsworth, South Africa, 4084
    - Recruiting
    - Clinical Trial Site
  - City of Johannesburg, South Africa, 1820
    - Recruiting
    - Clinical Trial Site
  - Durban, South Africa, 4001
    - Recruiting
    - Clinical Trial Site
  - Durban, South Africa, 4170
    - Recruiting
    - Clinical Trial Site
  - Durban, South Africa, 4091
    - Not yet recruiting
    - Clinical Trial Site
  - Durban, South Africa, 4320
    - Not yet recruiting
    - Clinical Trial Site
  - Ekurhuleni, South Africa, 1459
    - Recruiting
    - Clinical Trial Site
  - Ekurhuleni, South Africa, 1466
    - Recruiting
    - Clinical Trial Site
  - Ekurhuleni, South Africa, 1619
    - Recruiting
    - Clinical Trial Site
  - Gauteng, South Africa, 0157
    - Recruiting
    - Clinical Trial Site
  - Johannesburg, South Africa, 1818
    - Recruiting
    - Clinical Trial Site
  - Johannesburg, South Africa, 2157
    - Not yet recruiting
    - Clinical Trial Site
  - Johannesburg, South Africa, 2192
    - Recruiting
    - Clinical Trial Site
  - Johannesburg, South Africa, 2196
    - Recruiting
    - Clinical Trial Site
  - KwaDukuza, South Africa, 4449
    - Recruiting
    - Clinical Trial Site
  - KwaZulu - Natal, South Africa, 4449
    - Recruiting
    - Clinical Trial Site
  - Mogale City, South Africa, 1739
    - Recruiting
    - Clinical Trial Site
  - Mossel Bay, South Africa, 6506
    - Recruiting
    - Clinical Trial Site
  - Nelson Mandela Bay, South Africa, 6001
    - Recruiting
    - Clinical Trial Site
  - Plettenberg Bay, South Africa, 6600
    - Recruiting
    - Clinical Trial Site
  - Pretoria, South Africa, 0002
    - Recruiting
    - Clinical Trial Site
  - Pretoria, South Africa, 0183
    - Recruiting
    - Clinical Trial Site
  - Pretoria, South Africa, 0186
    - Recruiting
    - Clinical Trial Site
  - Worcester, South Africa, 6850
    - Recruiting
    - Clinical Trial Site
South Korea
- - Anyang-si, South Korea, 14068
    - Not yet recruiting
    - Clinical Trial Site
  - Busan, South Korea, 47392
    - Not yet recruiting
    - Clinical Trial Site
  - Changwon-si, South Korea, 51472
    - Not yet recruiting
    - Clinical Trial Site
  - Cheongju-si, South Korea, 28644
    - Not yet recruiting
    - Clinical Trial Site
  - Daejeon, South Korea, 35015
    - Not yet recruiting
    - Clinical Trial Site
  - Goyang-si, South Korea, 10326
    - Not yet recruiting
    - Clinical Trial Site
  - Gwangju, South Korea, 61453
    - Not yet recruiting
    - Clinical Trial Site
  - Gwangmyeong, South Korea, 14353
    - Not yet recruiting
    - Clinical Trial Site
  - Jeonju, South Korea, 54907
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 02841
    - Recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 02053
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 02447
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 04763
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 05278
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 05368
    - Not yet recruiting
    - Clinical Trial Site
  - Seoul, South Korea, 07804
    - Not yet recruiting
    - Clinical Trial Site
  - Wŏnju, South Korea, 26426
    - Recruiting
    - Clinical Trial Site
Spain
- - Alcalá de Henares, Spain, 28880
    - Not yet recruiting
    - Clinical Trial Site
  - Antequera, Spain, 29200
    - Recruiting
    - Clinical Trial Site
  - Badajoz, Spain, 06006
    - Recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 08035
    - Recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 08036
    - Recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 08025
    - Recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 08023
    - Recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 28002
    - Not yet recruiting
    - Clinical Trial Site
  - Barcelona, Spain, 08025
    - Not yet recruiting
    - Clinical Trial Site
  - Burjassot, Spain, 46100
    - Recruiting
    - Clinical Trial Site
  - Cadiz, Spain, 11650
    - Recruiting
    - Clinical Trial Site
  - Centelles, Spain, 08540
    - Recruiting
    - Clinical Trial Site
  - Córdoba, Spain, 14004
    - Recruiting
    - Clinical Trial Site
  - El Palmar, Spain, 30120
    - Not yet recruiting
    - Clinical Trial Site
  - Figueres, Spain, 17600
    - Not yet recruiting
    - Clinical Trial Site
  - Huelva, Spain, 21080
    - Recruiting
    - Clinical Trial Site
  - L'Hospitalet de Llobregat, Spain, 8907
    - Not yet recruiting
    - Clinical Trial Site
  - Lugo, Spain, 27003
    - Not yet recruiting
    - Clinical Trial Site
  - Madrid, Spain, 28003
    - Recruiting
    - Clinical Trial Site
  - Madrid, Spain, 28040
    - Recruiting
    - Clinical Trial Site
  - Madrid, Spain, 28040
    - Not yet recruiting
    - Clinical Trial Site
  - Madrid, Spain, 28041
    - Not yet recruiting
    - Clinical Trial Site
  - Marbella, Spain, 29603
    - Recruiting
    - Clinical Trial Site
  - Pamplona, Spain, 31008
    - Recruiting
    - Clinical Trial Site
  - Peralada, Spain, 17491
    - Recruiting
    - Clinical Trial Site
  - San Sebastián de los Reyes, Spain, 28702
    - Not yet recruiting
    - Clinical Trial Site
  - Santiago de Compostela, Spain, 15706
    - Recruiting
    - Clinical Trial Site
  - Santiago de Compostela, Spain, 15702
    - Not yet recruiting
    - Clinical Trial Site
  - Segovia, Spain, 40002
    - Not yet recruiting
    - Clinical Trial Site
  - Seville, Spain, 41003
    - Not yet recruiting
    - Clinical Trial Site
  - Seville, Spain, 41950
    - Recruiting
    - Clinical Trial Site
  - Torrejón de Ardoz, Spain, 28850
    - Not yet recruiting
    - Clinical Trial Site
  - Valencia, Spain, 46010
    - Recruiting
    - Clinical Trial Site
  - Valencia, Spain, 46015
    - Not yet recruiting
    - Clinical Trial Site
  - Valladolid, Spain, 47012
    - Not yet recruiting
    - Clinical Trial Site
  - Vigo, Spain, 36213
    - Recruiting
    - Clinical Trial Site
Sweden
- - Stockholm, Sweden, 117 27
    - Recruiting
    - Clinical Trial Site
Taiwan
- - Kaohsiung City, Taiwan, 82445
    - Not yet recruiting
    - Clinical Trial Site
  - New Taipei City, Taiwan, 235041
    - Not yet recruiting
    - Clinical Trial Site
  - Taipei, Taiwan, 10002
    - Recruiting
    - Clinical Trial Site
  - Taipei, Taiwan, 104
    - Not yet recruiting
    - Clinical Trial Site
  - Taipei, Taiwan, 106
    - Not yet recruiting
    - Clinical Trial Site
  - Taipei, Taiwan, 114202
    - Not yet recruiting
    - Clinical Trial Site
Turkey (Türkiye)
- - Istanbul, Turkey (Türkiye), 34093
    - Not yet recruiting
    - Clinical Trial Site
  - Izmir, Turkey (Türkiye), 35330
    - Not yet recruiting
    - Clinical Trial Site
  - Sivas, Turkey (Türkiye), 58140
    - Not yet recruiting
    - Clinical Trial Site
United Kingdom
- - Ashburton, United Kingdom, TQ13 7AP
    - Recruiting
    - Clinical Trial Site
  - Belfast, United Kingdom, BT2 8BG
    - Recruiting
    - Clinical Trial Site
  - Bellshill, United Kingdom, ML4 3NJ
    - Recruiting
    - Clinical Trial Site
  - Birmingham, United Kingdom, B15 2SQ
    - Recruiting
    - Clinical Trial Site
  - Birmingham, United Kingdom, B21 9RY
    - Recruiting
    - Clinical Trial Site
  - Bristol, United Kingdom, BS2 8HW
    - Recruiting
    - Clinical Trial Site
  - Bristol, United Kingdom, BS37 4AX
    - Recruiting
    - Clinical Trial Site
  - Bury St Edmunds, United Kingdom, IP33 2QZ
    - Recruiting
    - Clinical Trial Site
  - Cambridge, United Kingdom, CB2 0QQ
    - Not yet recruiting
    - Clinical Trial Site
  - Cardiff, United Kingdom, CF15 9SS
    - Recruiting
    - Clinical Trial Site
  - Cardiff, United Kingdom, CF5 4AD
    - Recruiting
    - Clinical Trial Site
  - Chichester, United Kingdom, PO19 6SE
    - Recruiting
    - Clinical Trial Site
  - Corby, United Kingdom, NN17 2UR
    - Recruiting
    - Clinical Trial Site
  - Darlington, United Kingdom, DL3 6HX
    - Recruiting
    - Clinical Trial Site
  - Dorchester, United Kingdom, DT1 2JY
    - Not yet recruiting
    - Clinical Trial Site
  - Ely, United Kingdom, CB7 5JD
    - Recruiting
    - Clinical Trial Site
  - Fowey, United Kingdom, PL23 1DT
    - Recruiting
    - Clinical Trial Site
  - Glasgow, United Kingdom, G20 7BE
    - Recruiting
    - Clinical Trial Site
  - Heston, United Kingdom, TW5 9ER
    - Recruiting
    - Clinical Trial Site
  - Honiton, United Kingdom, EX14 2NY
    - Recruiting
    - Clinical Trial Site
  - Ilford, United Kingdom, IG1 4HP
    - Recruiting
    - Clinical Trial Site
  - Isleworth, United Kingdom, TW7 6AF
    - Not yet recruiting
    - Clinical Trial Site
  - Leeds, United Kingdom, LS26 9AA
    - Recruiting
    - Clinical Trial Site
  - Liskeard, United Kingdom, PL14 3XA
    - Recruiting
    - Clinical Trial Site
  - Liverpool, United Kingdom, L24 7RB
    - Recruiting
    - Clinical Trial Site
  - Liverpool, United Kingdom, L9 7AL
    - Not yet recruiting
    - Clinical Trial Site
  - London, United Kingdom, EC1A 7BE
    - Recruiting
    - Clinical Trial Site
  - London, United Kingdom, SE6 4LF
    - Recruiting
    - Clinical Trial Site
  - Luton, United Kingdom, LU4 0DZ
    - Not yet recruiting
    - Clinical Trial Site
  - Manchester, United Kingdom, M27 8FF
    - Recruiting
    - Clinical Trial Site
  - Metropolitan Borough of Wirral, United Kingdom, CH62 6EE
    - Recruiting
    - Clinical Trial Site
  - Middlesbrough, United Kingdom, TS5 6HA
    - Recruiting
    - Clinical Trial Site
  - Milton Keynes, United Kingdom, MK15 0DU
    - Recruiting
    - Clinical Trial Site
  - Newquay, United Kingdom, TR7 1RU
    - Recruiting
    - Clinical Trial Site
  - Northallerton, United Kingdom, DL7 8AW
    - Recruiting
    - Clinical Trial Site
  - Penzance, United Kingdom, TR18 3DX
    - Recruiting
    - Clinical Trial Site
  - Plymouth, United Kingdom, PL5 3JB
    - Recruiting
    - Clinical Trial Site
  - Plympton, United Kingdom, PL7 1AD
    - Not yet recruiting
    - Clinical Trial Site
  - Poole, United Kingdom, BH16 5PW
    - Recruiting
    - Clinical Trial Site
  - Redhill, United Kingdom, RH1 5RH
    - Recruiting
    - Clinical Trial Site
  - Sale, United Kingdom, M33 4BR
    - Recruiting
    - Clinical Trial Site
  - Swansea, United Kingdom, SA2 8QA
    - Recruiting
    - Clinical Trial Site
  - Swindon, United Kingdom, SN3 6BB
    - Not yet recruiting
    - Clinical Trial Site
  - Teeside, United Kingdom, TS19 8PE
    - Recruiting
    - Clinical Trial Site
  - Thetford, United Kingdom, IP24 1JD
    - Recruiting
    - Clinical Trial Site
  - Torpoint, United Kingdom, PL11 2TB
    - Recruiting
    - Clinical Trial Site
  - Wolverhampton, United Kingdom, WV9 5HB
    - Recruiting
    - Clinical Trial Site
  - York, United Kingdom, YO24 2RQ
    - Recruiting
    - Clinical Trial Site
United States
- Alabama
  - Birmingham, Alabama, United States, 35211
    - Recruiting
    - Clinical Trial Site
  - Birmingham, Alabama, United States, 35205
    - Not yet recruiting
    - Clinical Trial Site
  - Fairhope, Alabama, United States, 36532
    - Recruiting
    - Clinical Trial Site
  - Foley, Alabama, United States, 36535
    - Recruiting
    - Clinical Trial Site
  - Huntsville, Alabama, United States, 35805
    - Recruiting
    - Clinical Trial Site
  - Huntsville, Alabama, United States, 35801
    - Not yet recruiting
    - Clinical Trial Site
  - Sheffield, Alabama, United States, 35660
    - Recruiting
    - Clinical Trial Site
- Arizona
  - Chandler, Arizona, United States, 85224
    - Recruiting
    - Clinical Trial Site
  - Gilbert, Arizona, United States, 85296
    - Recruiting
    - Clinical Trial Site
  - Glendale, Arizona, United States, 85308
    - Not yet recruiting
    - Clinical Trial Site
  - Mesa, Arizona, United States, 85213
    - Not yet recruiting
    - Clinical Trial Site
  - Phoenix, Arizona, United States, 85020
    - Recruiting
    - Clinical Trial Site
  - Phoenix, Arizona, United States, 85015
    - Recruiting
    - Clinical Trial Site
  - Sun City West, Arizona, United States, 85375
    - Recruiting
    - Clinical Trial Site
  - Tempe, Arizona, United States, 85283
    - Not yet recruiting
    - Clinical Trial Site
  - Tucson, Arizona, United States, 85741
    - Recruiting
    - Clinical Trial Site
  - Tucson, Arizona, United States, 85715
    - Recruiting
    - Clinical Trial Site
  - Yuma, Arizona, United States, 85364
    - Recruiting
    - Clinical Trial Site
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Recruiting
    - Clinical Trial Site
  - Little Rock, Arkansas, United States, 72204
    - Recruiting
    - Clinical Trial Site
- California
  - Beverly Hills, California, United States, 90211
    - Recruiting
    - Clinical Trial Site
  - Chula Vista, California, United States, 91910
    - Recruiting
    - Clinical Trial Site
  - Covina, California, United States, 91723
    - Recruiting
    - Clinical Trial Site
  - Escondido, California, United States, 92025
    - Recruiting
    - Clinical Trial Site
  - Glendale, California, United States, 91206
    - Recruiting
    - Clinical Trial Site
  - Huntington Beach, California, United States, 92648
    - Not yet recruiting
    - Clinical Trial Site
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - Clinical Trial Site
  - Lancaster, California, United States, 93534
    - Recruiting
    - Clinical Trial Site
  - Long Beach, California, United States, 90815
    - Recruiting
    - Clinical Trial Site
  - Lynwood, California, United States, 90262
    - Recruiting
    - Clinical Trial Site
  - Newhall, California, United States, 91321
    - Recruiting
    - Clinical Trial Site
  - Northridge, California, United States, 91325
    - Recruiting
    - Clinical Trial Site
  - Pasadena, California, United States, 91105
    - Recruiting
    - Clinical Trial Site
  - San Diego, California, United States, 92111
    - Recruiting
    - Clinical Trial Site
  - San Dimas, California, United States, 91773
    - Recruiting
    - Clinical Trial Site
  - San Ramon, California, United States, 94583
    - Not yet recruiting
    - Clinical Trial Site
  - Tarzana, California, United States, 91356
    - Recruiting
    - Clinical Trial Site
  - Toluca Lake, California, United States, 91602
    - Recruiting
    - Clinical Trial Site
  - Torrance, California, United States, 90502
    - Not yet recruiting
    - Clinical Trial Site
  - Tustin, California, United States, 92780
    - Recruiting
    - Clinical Trial Site
  - Vista, California, United States, 92081
    - Recruiting
    - Clinical Trial Site
  - Walnut Creek, California, United States, 94598
    - Recruiting
    - Clinical Trial Site
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Recruiting
    - Clinical Trial Site
  - Waterbury, Connecticut, United States, 06708
    - Not yet recruiting
    - Clinical Trial Site
- Florida
  - Boca Raton, Florida, United States, 33434
    - Recruiting
    - Clinical Trial Site
  - Brandon, Florida, United States, 33511
    - Recruiting
    - Clinical Trial Site
  - Fleming Island, Florida, United States, 32003
    - Recruiting
    - Clinical Trial Site
  - Fort Lauderdale, Florida, United States, 33308
    - Recruiting
    - Clinical Trial Site
  - Hialeah, Florida, United States, 33012
    - Recruiting
    - Clinical Trial Site
  - Hollywood, Florida, United States, 33024
    - Recruiting
    - Clinical Trial Site
  - Homestead, Florida, United States, 33030
    - Recruiting
    - Clinical Trial Site
  - Jacksonville, Florida, United States, 32216
    - Recruiting
    - Clinical Trial Site
  - Jacksonville, Florida, United States, 32205
    - Recruiting
    - Clinical Trial Site
  - Jensen Beach, Florida, United States, 34957
    - Recruiting
    - Clinical Trial Site
  - Leesburg, Florida, United States, 34748
    - Recruiting
    - Clinical Trial Site
  - Melbourne, Florida, United States, 32934
    - Recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33135
    - Recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33186
    - Recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33155
    - Recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33126
    - Not yet recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33134
    - Recruiting
    - Clinical Trial Site
  - Miami, Florida, United States, 33169
    - Not yet recruiting
    - Clinical Trial Site
  - Orlando, Florida, United States, 32825
    - Recruiting
    - Clinical Trial Site
  - Palm Springs, Florida, United States, 33406
    - Recruiting
    - Clinical Trial Site
  - Tampa, Florida, United States, 33615
    - Recruiting
    - Clinical Trial Site
  - Wellington, Florida, United States, 33449
    - Recruiting
    - Clinical Trial Site
  - Winter Park, Florida, United States, 32789
    - Not yet recruiting
    - Clinical Trial Site
- Georgia
  - Atlanta, Georgia, United States, 30342
    - Recruiting
    - Clinical Trial Site
  - Brunswick, Georgia, United States, 31520
    - Recruiting
    - Clinical Trial Site
  - Columbus, Georgia, United States, 31904
    - Recruiting
    - Clinical Trial Site
  - Columbus, Georgia, United States, 31901
    - Recruiting
    - Clinical Trial Site
  - Conyers, Georgia, United States, 30012
    - Recruiting
    - Clinical Trial Site
  - Conyers, Georgia, United States, 30094
    - Recruiting
    - Clinical Trial Site
  - Fayetteville, Georgia, United States, 30214
    - Recruiting
    - Clinical Trial Site
  - Hinesville, Georgia, United States, 31313
    - Not yet recruiting
    - Clinical Trial Site
  - Johns Creek, Georgia, United States, 30024
    - Recruiting
    - Clinical Trial Site
  - Lawrenceville, Georgia, United States, 30044
    - Recruiting
    - Clinical Trial Site
  - Macon, Georgia, United States, 31201
    - Recruiting
    - Clinical Trial Site
  - Stonecrest, Georgia, United States, 30038
    - Not yet recruiting
    - Clinical Trial Site
  - Suwanee, Georgia, United States, 30024
    - Not yet recruiting
    - Clinical Trial Site
  - Thomasville, Georgia, United States, 31792
    - Not yet recruiting
    - Clinical Trial Site
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Not yet recruiting
    - Clinical Trial Site
  - Chicago, Illinois, United States, 60611
    - Not yet recruiting
    - Clinical Trial Site
  - Chicago, Illinois, United States, 60640
    - Recruiting
    - Clinical Trial Site
  - Hazel Crest, Illinois, United States, 60429
    - Recruiting
    - Clinical Trial Site
  - Oak Brook, Illinois, United States, 60523
    - Recruiting
    - Clinical Trial Site
  - Orland Park, Illinois, United States, 60462
    - Recruiting
    - Clinical Trial Site
  - Springfield, Illinois, United States, 62701
    - Recruiting
    - Clinical Trial Site
  - Tinley Park, Illinois, United States, 60477
    - Recruiting
    - Clinical Trial Site
- Indiana
  - Avon, Indiana, United States, 46123
    - Recruiting
    - Clinical Trial Site
  - Carmel, Indiana, United States, 46290
    - Not yet recruiting
    - Clinical Trial Site
  - Evansville, Indiana, United States, 47714
    - Recruiting
    - Clinical Trial Site
  - Evansville, Indiana, United States, 47715
    - Recruiting
    - Clinical Trial Site
  - Franklin, Indiana, United States, 46131
    - Not yet recruiting
    - Clinical Trial Site
  - Greenfield, Indiana, United States, 46140
    - Recruiting
    - Clinical Trial Site
  - South Bend, Indiana, United States, 46617
    - Recruiting
    - Clinical Trial Site
  - Valparaiso, Indiana, United States, 46383
    - Recruiting
    - Clinical Trial Site
- Kansas
  - Hutchinson, Kansas, United States, 67502
    - Recruiting
    - Clinical Trial Site
  - Topeka, Kansas, United States, 66606
    - Recruiting
    - Clinical Trial Site
  - Wichita, Kansas, United States, 67214
    - Recruiting
    - Clinical Trial Site
  - Wichita, Kansas, United States, 67218
    - Recruiting
    - Clinical Trial Site
- Kentucky
  - Bowling Green, Kentucky, United States, 42101
    - Recruiting
    - Clinical Trial Site
  - Lexington, Kentucky, United States, 40503
    - Recruiting
    - Clinical Trial Site
  - Versailles, Kentucky, United States, 40383
    - Recruiting
    - Clinical Trial Site
- Louisiana
  - Hammond, Louisiana, United States, 70403
    - Recruiting
    - Clinical Trial Site
  - Lafayette, Louisiana, United States, 70503
    - Recruiting
    - Clinical Trial Site
  - New Orleans, Louisiana, United States, 70112
    - Not yet recruiting
    - Clinical Trial Site
  - Opelousas, Louisiana, United States, 70570
    - Recruiting
    - Clinical Trial Site
  - Shreveport, Louisiana, United States, 71105
    - Recruiting
    - Clinical Trial Site
  - Slidell, Louisiana, United States, 70458
    - Not yet recruiting
    - Clinical Trial Site
  - Zachary, Louisiana, United States, 70791
    - Recruiting
    - Clinical Trial Site
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Recruiting
    - Clinical Trial Site
  - Baltimore, Maryland, United States, 21215
    - Not yet recruiting
    - Clinical Trial Site
  - Beltsville, Maryland, United States, 20705
    - Recruiting
    - Clinical Trial Site
  - Bowie, Maryland, United States, 20715
    - Recruiting
    - Clinical Trial Site
  - Lanham, Maryland, United States, 20706
    - Recruiting
    - Clinical Trial Site
  - Rockville, Maryland, United States, 20850
    - Recruiting
    - Clinical Trial Site
- Michigan
  - Flint, Michigan, United States, 48504
    - Recruiting
    - Clinical Trial Site
  - Petoskey, Michigan, United States, 49770
    - Not yet recruiting
    - Clinical Trial Site
  - Shelby, Michigan, United States, 48315
    - Recruiting
    - Clinical Trial Site
  - Southfield, Michigan, United States, 48075
    - Recruiting
    - Clinical Trial Site
  - Troy, Michigan, United States, 48085
    - Recruiting
    - Clinical Trial Site
  - Troy, Michigan, United States, 48098
    - Recruiting
    - Clinical Trial Site
- Minnesota
  - Richfield, Minnesota, United States, 55423
    - Recruiting
    - Clinical Trial Site
  - Saint Cloud, Minnesota, United States, 56303
    - Not yet recruiting
    - Clinical Trial Site
- Mississippi
  - Jackson, Mississippi, United States, 39216
    - Recruiting
    - Clinical Trial Site
  - Olive Branch, Mississippi, United States, 38654
    - Recruiting
    - Clinical Trial Site
  - Port Gibson, Mississippi, United States, 39150
    - Recruiting
    - Clinical Trial Site
  - Ridgeland, Mississippi, United States, 39157
    - Recruiting
    - Clinical Trial Site
  - Tupelo, Mississippi, United States, 38801
    - Not yet recruiting
    - Clinical Trial Site
- Missouri
  - Kansas City, Missouri, United States, 64108
    - Not yet recruiting
    - Clinical Trial Site
  - Kansas City, Missouri, United States, 64111
    - Recruiting
    - Clinical Trial Site
  - Kansas City, Missouri, United States, 64151
    - Recruiting
    - Clinical Trial Site
  - St Louis, Missouri, United States, 63141
    - Not yet recruiting
    - Clinical Trial Site
  - St Louis, Missouri, United States, 63136
    - Recruiting
    - Clinical Trial Site
- Nebraska
  - Fremont, Nebraska, United States, 68025
    - Recruiting
    - Clinical Trial Site
  - Omaha, Nebraska, United States, 68114
    - Not yet recruiting
    - Clinical Trial Site
- Nevada
  - Las Vegas, Nevada, United States, 89121
    - Recruiting
    - Clinical Trial Site
  - Las Vegas, Nevada, United States, 89102
    - Not yet recruiting
    - Clinical Trial Site
  - Las Vegas, Nevada, United States, 89148
    - Recruiting
    - Clinical Trial Site
- New Hampshire
  - Portsmouth, New Hampshire, United States, 03801
    - Not yet recruiting
    - Clinical Trial Site
- New Jersey
  - Brick, New Jersey, United States, 08724
    - Recruiting
    - Clinical Trial Site
  - Bridgewater, New Jersey, United States, 08807
    - Recruiting
    - Clinical Trial Site
  - Flemington, New Jersey, United States, 08822
    - Recruiting
    - Clinical Trial Site
- New Mexico
  - Albuquerque, New Mexico, United States, 87106
    - Recruiting
    - Clinical Trial Site
- New York
  - New Windsor, New York, United States, 12553
    - Recruiting
    - Clinical Trial Site
  - North Massapequa, New York, United States, 11758
    - Recruiting
    - Clinical Trial Site
  - Poughkeepsie, New York, United States, 12601
    - Not yet recruiting
    - Clinical Trial Site
  - Riverhead, New York, United States, 11901
    - Recruiting
    - Clinical Trial Site
  - Rosedale, New York, United States, 11422
    - Recruiting
    - Clinical Trial Site
  - Saratoga Springs, New York, United States, 12866
    - Not yet recruiting
    - Clinical Trial Site
  - The Bronx, New York, United States, 10461
    - Recruiting
    - Clinical Trial Site
  - West Seneca, New York, United States, 14224
    - Recruiting
    - Clinical Trial Site
  - Westfield, New York, United States, 14787
    - Recruiting
    - Clinical Trial Site
- North Carolina
  - Durham, North Carolina, United States, 27704
    - Recruiting
    - Clinical Trial Site
  - Greenville, North Carolina, United States, 27834
    - Recruiting
    - Clinical Trial Site
  - High Point, North Carolina, United States, 27260
    - Recruiting
    - Clinical Trial Site
  - Jacksonville, North Carolina, United States, 28546
    - Recruiting
    - Clinical Trial Site
  - Kings Mountain, North Carolina, United States, 28086
    - Recruiting
    - Clinical Trial Site
  - Monroe, North Carolina, United States, 28112
    - Recruiting
    - Clinical Trial Site
  - Statesville, North Carolina, United States, 28625
    - Recruiting
    - Clinical Trial Site
- North Dakota
  - Fargo, North Dakota, United States, 58104
    - Recruiting
    - Clinical Trial Site
- Ohio
  - Beavercreek, Ohio, United States, 45431
    - Recruiting
    - Clinical Trial Site
  - Cincinnati, Ohio, United States, 45219
    - Recruiting
    - Clinical Trial Site
  - Cincinnati, Ohio, United States, 45212
    - Recruiting
    - Clinical Trial Site
  - Columbus, Ohio, United States, 43213
    - Recruiting
    - Clinical Trial Site
  - Dayton, Ohio, United States, 45409
    - Recruiting
    - Clinical Trial Site
  - Dayton, Ohio, United States, 45429
    - Not yet recruiting
    - Clinical Trial Site
  - Lima, Ohio, United States, 45801
    - Recruiting
    - Clinical Trial Site
  - Maumee, Ohio, United States, 43537
    - Recruiting
    - Clinical Trial Site
  - Moraine, Ohio, United States, 45439
    - Recruiting
    - Clinical Trial Site
- Oklahoma
  - Edmond, Oklahoma, United States, 73013
    - Not yet recruiting
    - Clinical Trial Site
  - Moore, Oklahoma, United States, 73160
    - Recruiting
    - Clinical Trial Site
  - Norman, Oklahoma, United States, 73069
    - Recruiting
    - Clinical Trial Site
  - Oklahoma City, Oklahoma, United States, 73120
    - Recruiting
    - Clinical Trial Site
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17701
    - Recruiting
    - Clinical Trial Site
  - Horsham, Pennsylvania, United States, 19044
    - Recruiting
    - Clinical Trial Site
  - Linwood, Pennsylvania, United States, 19061
    - Recruiting
    - Clinical Trial Site
  - Media, Pennsylvania, United States, 19063
    - Recruiting
    - Clinical Trial Site
  - Uniontown, Pennsylvania, United States, 15401
    - Recruiting
    - Clinical Trial Site
- South Carolina
  - Columbia, South Carolina, United States, 29205
    - Recruiting
    - Clinical Trial Site
  - Greenville, South Carolina, United States, 29607
    - Recruiting
    - Clinical Trial Site
  - Greer, South Carolina, United States, 29650
    - Recruiting
    - Clinical Trial Site
- South Dakota
  - Sioux Falls, South Dakota, United States, 57104
    - Not yet recruiting
    - Clinical Trial Site
- Tennessee
  - Chattanooga, Tennessee, United States, 37404
    - Not yet recruiting
    - Clinical Trial Site
  - Chattanooga, Tennessee, United States, 37412
    - Recruiting
    - Clinical Trial Site
  - Knoxville, Tennessee, United States, 37909
    - Recruiting
    - Clinical Trial Site
  - Knoxville, Tennessee, United States, 37923
    - Recruiting
    - Clinical Trial Site
- Texas
  - Allen, Texas, United States, 75013
    - Recruiting
    - Clinical Trial Site
  - Amarillo, Texas, United States, 79124
    - Recruiting
    - Clinical Trial Site
  - Amarillo, Texas, United States, 79106
    - Recruiting
    - Clinical Trial Site
  - Arlington, Texas, United States, 76012
    - Recruiting
    - Clinical Trial Site
  - Arlington, Texas, United States, 76015
    - Not yet recruiting
    - Clinical Trial Site
  - Austin, Texas, United States, 78735
    - Recruiting
    - Clinical Trial Site
  - Austin, Texas, United States, 78759
    - Recruiting
    - Clinical Trial Site
  - Beaumont, Texas, United States, 77702
    - Recruiting
    - Clinical Trial Site
  - Carrollton, Texas, United States, 75006
    - Recruiting
    - Clinical Trial Site
  - Dallas, Texas, United States, 75246
    - Not yet recruiting
    - Clinical Trial Site
  - Dallas, Texas, United States, 75226
    - Not yet recruiting
    - Clinical Trial Site
  - Dallas, Texas, United States, 75235
    - Not yet recruiting
    - Clinical Trial Site
  - Duncanville, Texas, United States, 75137
    - Recruiting
    - Clinical Trial Site
  - El Paso, Texas, United States, 79905
    - Not yet recruiting
    - Clinical Trial Site
  - Euless, Texas, United States, 76040
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77024
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77002
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77036
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77025
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77061
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77043
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77070
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77095
    - Recruiting
    - Clinical Trial Site
  - Houston, Texas, United States, 77429
    - Recruiting
    - Clinical Trial Site
  - Humble, Texas, United States, 77338
    - Recruiting
    - Clinical Trial Site
  - Katy, Texas, United States, 77450
    - Recruiting
    - Clinical Trial Site
  - Kingwood, Texas, United States, 77339
    - Not yet recruiting
    - Clinical Trial Site
  - Laredo, Texas, United States, 78041
    - Recruiting
    - Clinical Trial Site
  - McAllen, Texas, United States, 78503
    - Recruiting
    - Clinical Trial Site
  - McKinney, Texas, United States, 75071
    - Recruiting
    - Clinical Trial Site
  - McKinney, Texas, United States, 75069
    - Not yet recruiting
    - Clinical Trial Site
  - Mesquite, Texas, United States, 75149
    - Recruiting
    - Clinical Trial Site
  - Missouri City, Texas, United States, 77459
    - Recruiting
    - Clinical Trial Site
  - Paris, Texas, United States, 75462
    - Recruiting
    - Clinical Trial Site
  - Pasadena, Texas, United States, 77504
    - Recruiting
    - Clinical Trial Site
  - Plano, Texas, United States, 75024
    - Recruiting
    - Clinical Trial Site
  - Port Arthur, Texas, United States, 77642
    - Recruiting
    - Clinical Trial Site
  - San Antonio, Texas, United States, 78229
    - Recruiting
    - Clinical Trial Site
  - San Antonio, Texas, United States, 78258
    - Recruiting
    - Clinical Trial Site
  - San Antonio, Texas, United States, 78220
    - Recruiting
    - Clinical Trial Site
  - San Antonio, Texas, United States, 78231
    - Recruiting
    - Clinical Trial Site
  - Sherman, Texas, United States, 75092
    - Recruiting
    - Clinical Trial Site
  - Sugar Land, Texas, United States, 77479
    - Recruiting
    - Clinical Trial Site
  - Tomball, Texas, United States, 77375
    - Recruiting
    - Clinical Trial Site
  - Waco, Texas, United States, 76712
    - Recruiting
    - Clinical Trial Site
- Utah
  - Bountiful, Utah, United States, 84025
    - Recruiting
    - Clinical Trial Site
  - Bountiful, Utah, United States, 84010
    - Recruiting
    - Clinical Trial Site
  - Layton, Utah, United States, 84041
    - Recruiting
    - Clinical Trial Site
- Virginia
  - Arlington, Virginia, United States, 22205
    - Recruiting
    - Clinical Trial Site
  - Danville, Virginia, United States, 24541
    - Recruiting
    - Clinical Trial Site
  - Falls Church, Virginia, United States, 22042
    - Recruiting
    - Clinical Trial Site
  - Manassas, Virginia, United States, 20109
    - Recruiting
    - Clinical Trial Site
  - Newport News, Virginia, United States, 23606
    - Recruiting
    - Clinical Trial Site
  - Norfolk, Virginia, United States, 23502
    - Recruiting
    - Clinical Trial Site
  - Richmond, Virginia, United States, 23219
    - Recruiting
    - Clinical Trial Site
  - Suffolk, Virginia, United States, 23435
    - Recruiting
    - Clinical Trial Site
  - Winchester, Virginia, United States, 22601
    - Recruiting
    - Clinical Trial Site
- Washington
  - Bellevue, Washington, United States, 98007
    - Recruiting
    - Clinical Trial Site
- Wisconsin
  - Kenosha, Wisconsin, United States, 53144
    - Recruiting
    - Clinical Trial Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Is 18 years or older for patients with established cardiovascular disease (CVD)
Is 55 years or older for patients with high risk for CVD
Has established CVD (defined as coronary, cerebrovascular, or peripheral artery disease) or high risk for CVD
Has treated hypertension on stable therapy with at least 2 standard of care antihypertensive medications, one of which must be a thiazide, thiazide-like, or loop diuretic

Exclusion Criteria:

Has known history of secondary hypertension
Has symptomatic orthostatic hypotension
Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3×upper limit of normal (ULN)
Has total serum bilirubin >1.5×ULN
Has international normalized ratio (INR) >1.5
Has serum potassium >4.8 mEq/L
Has estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m^2

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Zilebesiran 300 mg Participants will be administered 300 mg zilebesiran subcutaneously (SC) once every 6 months as add-on therapy to their standard of care antihypertensive medications.	Drug: Zilebesiran Zilebesiran will be administered SC Other Names: ALN-AGT01
Placebo Comparator: Placebo Participants will be administered placebo SC once every 6 months as add-on therapy to their standard of care antihypertensive medications.	Drug: Placebo Placebo will be administered SC

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Time to First Occurrence of a Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, or Heart Failure (HF) Event (Hospitalization for HF or Urgent HF Visit) Time Frame: Up to approximately 5 years	Up to approximately 5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Change from Baseline in Mean Seated Office Systolic Blood Pressure (SBP) at Month 6 Time Frame: Baseline and Month 6	Baseline and Month 6
Time to First Occurrence of a Composite Endpoint of CV Death, Nonfatal MI, or Nonfatal Stroke Time Frame: Up to approximately 5 years	Up to approximately 5 years
Composite Endpoint of CV Death and Total (First and Subsequent) HF Events (Hospitalization for HF or Urgent HF Visit) Time Frame: Up to approximately 5 years	Up to approximately 5 years
Time to First Occurrence of Composite Endpoint of CV death, Nonfatal MI, Nonfatal Stroke, or Coronary Revascularization Time Frame: Up to approximately 5 years	Up to approximately 5 years
Time to All-cause Death Time Frame: Up to approximately 5 years	Up to approximately 5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Alnylam Pharmaceuticals

Collaborators

Hoffmann-La Roche

Investigators

Study Director: Medical Director, Alnylam Pharmaceuticals

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 22, 2025

Primary Completion (Estimated)

September 30, 2030

Study Completion (Estimated)

September 30, 2030

Study Registration Dates

First Submitted

September 12, 2025

First Submitted That Met QC Criteria

September 12, 2025

First Posted (Actual)

September 18, 2025

Study Record Updates

Last Update Posted (Actual)

May 14, 2026

Last Update Submitted That Met QC Criteria

May 12, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

ALN-AGT01-008
2025-522960-34-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Phase 2-4 trials:

Access to anonymized individual participant data that support these results is made available 12 months after study completion and not less than 12 months after the product and indication have been approved in the US and/or the EU.

Access to data may be declined where there is likelihood a patient could be identified or other feasibility issue, where there is a potential conflict of interest, a planned business activities or an actual or potential competitive risk. Data will be provided contingent upon the approval of a research proposal and the execution of a data sharing agreement. Timeframes for data access may vary and can take up to 6 months or more.

Requests for access to data can be submitted via the website www.vivli.org. Questions can also be directed to datasharing@alnylam.com.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Time Frame

Secondary Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Hypertension

Clinical Trials on Placebo

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Sponsors and Collaborators

Medical Conditions

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Conditions

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Dietary Supplements

Sponsor/Collaborators

Locations