A Two-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Part B) Ovarian Cancer (FRAmework-01)

May 26, 2026 updated by: Eli Lilly and Company

FRAmework-01: A Two-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) Versus Chemotherapy or Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer, and Sofetabart Mipitecan Plus Bevacizumab Versus Platinum-Based Chemotherapy Plus Bevacizumab in Platinum-Sensitive Ovarian Cancer.

This is a clinical study that has two parts. It is testing a potential new medicine called Sofetabart Mipitecan (LY4170156) for people with certain types of ovarian, peritoneal, and fallopian tube cancers. Part A looks at participants whose cancer no longer responds to platinum-based treatments (a type of chemotherapy). Part B looks at participants whose cancer still responds to platinum-based treatments. The researchers want to find out if Sofetabart Mipitecan works better than the usual treatments that doctors use now and to better understand how safe it is. Each participant's time in the study will depend on how they respond to the treatment.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1080

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Trial questions or participation questions 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Locations

  • Australia
      • Ballarat Central, Australia, 3350
        • Not yet recruiting
        • Ballarat Health Services
        • Contact:
          • Phone Number: 0353206500
        • Principal Investigator:
          • LeeNa Teo
      • Camperdown, Australia, 2050
        • Not yet recruiting
        • Chris O'Brien Lifehouse
        • Principal Investigator:
          • Michelle Harrison
        • Contact:
          • Phone Number: +61 2 8514 0149
      • Launceston, Australia, 7250
        • Not yet recruiting
        • Launceston General Hospital
        • Contact:
          • Phone Number: +61 3 6777 6777
        • Principal Investigator:
          • Jeremy Power
      • Malvern, Australia, 3144
        • Not yet recruiting
        • Cabrini Hospital - Malvern
        • Contact:
          • Phone Number: 1300300977
        • Principal Investigator:
          • Gary Richardson
      • Randwick, Australia, 2031
        • Not yet recruiting
        • Prince of Wales Hospital
        • Principal Investigator:
          • Yeh Chen Lee
      • Shepparton, Australia, 3630
        • Not yet recruiting
        • Goulburn Valley Health
        • Principal Investigator:
          • Arvind Sahu
        • Contact:
          • Phone Number: +61 3 5832 2322
      • Southport, Australia, 4215
        • Not yet recruiting
        • Gold Coast University Hospital
        • Contact:
          • Phone Number: (07) 5687 0633
        • Principal Investigator:
          • Sean Hill
      • St Leonards, Australia, 2065
        • Not yet recruiting
        • Royal North Shore Hospital
        • Principal Investigator:
          • Connie Diakos
      • Townsville, Australia, 4814
        • Not yet recruiting
        • The Townsville Hospital
        • Contact:
          • Phone Number: 61744331111
        • Principal Investigator:
          • Joanne Tan
      • Traralgon, Australia, 3844
        • Not yet recruiting
        • Latrobe Regional Health
        • Principal Investigator:
          • Bhavini Shah
  • Austria
      • Graz, Austria, 8036
        • Not yet recruiting
        • Medizinische Universität Graz
        • Principal Investigator:
          • Vassiliki Kolovetsiou Kreiner
      • Innsbruck, Austria, 6020
        • Not yet recruiting
        • Medizinische Universitaet Innsbruck
        • Principal Investigator:
          • Irina Tsibulak
      • Vienna, Austria, 1090
        • Not yet recruiting
        • Universitaetsklinikum Allgemeines Krankenhaus Wien
        • Principal Investigator:
          • Stephan Polterauer
        • Contact:
          • Phone Number: 004314040061030
  • Belgium
      • Anderlecht, Belgium, 1070
        • Not yet recruiting
        • Institut Jules Bordet
        • Contact:
          • Phone Number: 3225413279
        • Principal Investigator:
          • Laura Polastro
      • Bruges, Belgium, 8000
        • Not yet recruiting
        • AZ Sint-Jan Brugge-Oostende AV
        • Contact:
          • Phone Number: 3250452806
        • Principal Investigator:
          • Eveline De Cuypere
      • Edegem, Belgium, 2650
        • Not yet recruiting
        • Antwerp University Hospital
        • Contact:
          • Phone Number: +32 3 821 41 60
        • Principal Investigator:
          • Laure-Anne Teuwen
      • Ghent, Belgium, 9000
        • Not yet recruiting
        • AZ Maria Middelares
        • Principal Investigator:
          • Christof Vulsteke
        • Contact:
          • Phone Number: 3292469500
      • Leuven, Belgium, 3000
        • Not yet recruiting
        • UZ Leuven
        • Principal Investigator:
          • Els Van Nieuwenhuysen
        • Contact:
          • Phone Number: 016344634
  • Brazil
      • Belo Horizonte, Brazil, 30180-060
        • Not yet recruiting
        • Oncocentro de Minas Gerais
        • Principal Investigator:
          • Angelica Rodrigues
      • Belém, Brazil, 66063-495
        • Not yet recruiting
        • CPAM - Centro de Pesquisas da Amazônia
        • Contact:
          • Phone Number: 5591999809897
        • Principal Investigator:
          • Bruno Fernandes
      • Florianópolis, Brazil, 88020-210
        • Not yet recruiting
        • CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina
        • Contact:
          • Phone Number: 4833804828
        • Principal Investigator:
          • Maria Eduarda Meyer
      • Lago Sul, Brazil, 71635580
        • Not yet recruiting
        • Hospital Brasilia
        • Principal Investigator:
          • Romualdo Barroso-Sousa
      • Rio de Janeiro, Brazil, 22250-905
        • Not yet recruiting
        • Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
        • Principal Investigator:
          • Gustavo Bretas
      • Rio de Janeiro, Brazil, 22271-110
        • Not yet recruiting
        • Instituto D'Or Pesquisa e Ensino
        • Principal Investigator:
          • Eduardo Paulino
      • Salvador, Brazil, 41950-640
        • Not yet recruiting
        • Clinica Amo - Rio Vermelho
        • Principal Investigator:
          • Aknar Calabrich
        • Contact:
          • Phone Number: 557130218735
      • São Caetano do Sul, Brazil, 09541-270
        • Not yet recruiting
        • Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
        • Principal Investigator:
          • Patricia Santi
        • Contact:
          • Phone Number: 551149935491
  • Canada
      • Calgary, Canada, T2N 5G2
        • Not yet recruiting
        • Arthur J.E. Child Comprehensive Cancer Centre
        • Principal Investigator:
          • Prafull Ghatage
        • Contact:
          • Phone Number: 4025213721
      • Hamilton, Canada, L8V5C2
        • Not yet recruiting
        • Hamilton Health Sciences-Juravinski Cancer Centre
        • Principal Investigator:
          • Nidhi Kumar Tyagi
      • Montreal, Canada, H3T 1E2
        • Not yet recruiting
        • Jewish General Hospital
        • Principal Investigator:
          • Kim Ma
      • Sherbrooke, Canada, J1H 5N4
        • Not yet recruiting
        • Centre intégré universitaire de santé et de services sociaux de l'Estrie Centre Hospitalier Universitaire -T
        • Principal Investigator:
          • Paul Bessette
        • Contact:
          • Phone Number: 8193461110 x 12890
      • Surrey, Canada, V3V 0E8
        • Not yet recruiting
        • BC Cancer Surrey
        • Principal Investigator:
          • Aalok Kumar
        • Contact:
          • Phone Number: 604-587-4314
      • Toronto, Canada, M5G 2M9
        • Not yet recruiting
        • Princess Margaret Cancer Centre
        • Principal Investigator:
          • Amit Oza
      • Toronto, Canada, M4N 3M5
        • Not yet recruiting
        • Sunnybrook Research Institute
        • Contact:
          • Phone Number: 4164805000x4026
        • Principal Investigator:
          • Lilian Gien
  • China
      • Beijing, China, 100142
        • Not yet recruiting
        • Beijing Cancer Hospital
        • Principal Investigator:
          • Yunong Gao
      • Beijing, China, 100032
        • Not yet recruiting
        • Peking University First Hospital
        • Principal Investigator:
          • Jun Hu
      • Changchun, China, 130021
        • Not yet recruiting
        • The First Hospital of Jilin University
        • Principal Investigator:
          • Songling Zhang
      • Changde, China, 415003
        • Not yet recruiting
        • The First People's Hospital of Changde City
        • Principal Investigator:
          • Tao Wu
      • Changsha, China, 410008
        • Not yet recruiting
        • Xiangya Hospital Central South University
        • Principal Investigator:
          • Yu Zhang
      • Chengdu, China, 610072
        • Not yet recruiting
        • Sichuan Provincial People's Hospital
        • Principal Investigator:
          • honglin hu
      • Fuzhou, China, 350014
        • Not yet recruiting
        • Fujian Cancer Hospital
        • Principal Investigator:
          • An Lin
      • Guangzhou, China, 510280
        • Recruiting
        • Zhujiang Hospital
        • Principal Investigator:
          • Xuefeng Wang
      • Guangzhou, China, 510120
        • Not yet recruiting
        • Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
        • Principal Investigator:
          • Qunxian Rao
      • Guangzhou, China, 511400
        • Not yet recruiting
        • Sun Yat-Sen University Cancer Centre
        • Principal Investigator:
          • Jundong Li
      • Hangzhou, China, 310022
        • Not yet recruiting
        • Zhejiang Cancer Hospital
        • Principal Investigator:
          • Jianqing Zhu
      • Jinan, China, 250117
        • Not yet recruiting
        • Shandong Cancer Hospital
        • Principal Investigator:
          • Liang Chen
      • Lanzhou, China, 730050
        • Not yet recruiting
        • Gansu Provincial Maternity and Child Care Hospital
        • Principal Investigator:
          • Chongli Guan
      • Luoyang, China, 471023
        • Not yet recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Contact:
          • Phone Number: 15225067070
        • Principal Investigator:
          • Dongmei Fan
      • Nanjing, China, 210029
        • Not yet recruiting
        • Jiangsu Province Hospital
        • Principal Investigator:
          • Wenjun Cheng
      • Nanjing, China, 210000
        • Not yet recruiting
        • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
        • Principal Investigator:
          • Huaijun Zhou
      • Nanning, China, 530021
        • Not yet recruiting
        • Guangxi Medical University Affiliated Tumor Hospital
        • Principal Investigator:
          • He Wang
      • Shanghai, China, 200032
        • Recruiting
        • Fudan University Shanghai Cancer Center
        • Principal Investigator:
          • Xiaohua Wu
        • Contact:
          • Phone Number: 8613601772486
      • Shanghai, China, 200011; 200090
        • Not yet recruiting
        • Obstetrics & Gynecology Hospital of Fudan University
        • Principal Investigator:
          • Yisheng Wang
      • Shantou, China, 515031
        • Not yet recruiting
        • Cancer Hospital of Shantou University Medical College
        • Principal Investigator:
          • Li Zhou
      • Shenzhen, China, 518036
        • Not yet recruiting
        • Peking University Shenzhen Hospital
        • Principal Investigator:
          • Changzhong Li
      • Tianjin, China, 300060
        • Not yet recruiting
        • Tianjin Medical University Cancer Institute & Hospital
        • Principal Investigator:
          • Ke Wang
      • Wuhan, China, 430030
        • Not yet recruiting
        • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
        • Contact:
          • Phone Number: 18627906399
        • Principal Investigator:
          • Changyu Wang
      • Wuhan, China, 430022
        • Not yet recruiting
        • Wuhan Union Hospital
        • Principal Investigator:
          • Guiling Li
  • Czechia
      • Brno, Czechia, 602 00
        • Not yet recruiting
        • Fakultni Nemocnice Brno
        • Contact:
          • Phone Number: +420 532 238 276
        • Principal Investigator:
          • Marketa Bednarikova
      • Nový Jiín, Czechia, 741 01
        • Not yet recruiting
        • Nemocnice AGEL Nový Jičín a.s.
        • Principal Investigator:
          • Vojtech Tlusty
      • Olomouc, Czechia, 779 00
        • Not yet recruiting
        • Fakultni nemocnice Olomouc
        • Contact:
          • Phone Number: 420588444295
        • Principal Investigator:
          • Bohuslav Melichar
      • Prague, Czechia, 12808
        • Not yet recruiting
        • Vseobecna fakultni nemocnice v Praze
        • Principal Investigator:
          • David Cibula
        • Contact:
          • Phone Number: +420224967451
      • Zlín, Czechia, 762 75
        • Not yet recruiting
        • Nemocnice Tomase Bati ve Zline
        • Principal Investigator:
          • Marketa Pospiskova
        • Contact:
          • Phone Number: +420577552344
  • Denmark
      • Copenhagen, Denmark, 2100
        • Not yet recruiting
        • Rigshospitalet
        • Principal Investigator:
          • Trine Noettrup
      • Vejle, Denmark, 7100
        • Not yet recruiting
        • Vejle Sygehus
        • Contact:
          • Phone Number: +45 79406815
        • Principal Investigator:
          • Caroline Thomsen
  • France
      • Angers, France, 49055
        • Not yet recruiting
        • Institut de Cancérologie de l'Ouest
        • Principal Investigator:
          • Paule Augereau
      • Bayonne, France, 64109
        • Not yet recruiting
        • Centre Hospitalier de La Cote Basque
        • Principal Investigator:
          • Thomas Grellety
        • Contact:
          • Phone Number: 33559443762
      • Bordeaux, France, 33076
        • Not yet recruiting
        • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
        • Principal Investigator:
          • Coriolan Lebreton
      • Brest, France, 29609
        • Not yet recruiting
        • CHRU de Brest
        • Principal Investigator:
          • Laura Deiana
      • Lille, France, 59020
        • Not yet recruiting
        • Centre Oscar Lambret
        • Principal Investigator:
          • Mathilde Saint-Ghislain
      • Limoges, France, 87042
        • Not yet recruiting
        • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
        • Principal Investigator:
          • Elise Deluche
        • Contact:
          • Phone Number: 0555056396
      • Lyon Cedex08, France, 69373
        • Not yet recruiting
        • Centre Leon Berard
        • Principal Investigator:
          • Isabelle-Laure Ray-Coquard
      • Montpellier, France, 34298
        • Not yet recruiting
        • Institut régional du Cancer Montpellier
        • Contact:
          • Phone Number: 334 67 61 24 19
        • Principal Investigator:
          • Stanislas QUESADA
      • Paris, France, 75020
        • Not yet recruiting
        • Groupe Hospitalier Diaconesses Croix Saint Simon
        • Contact:
          • Phone Number: 33144741013
        • Principal Investigator:
          • Antoine Angelergues
      • Paris, France, 75014
        • Not yet recruiting
        • Hopitaux Universitaires Paris Centre-Hopital Cochin
        • Principal Investigator:
          • Jerome Alexandre
      • Strasbourg, France, 67098
        • Not yet recruiting
        • CHU Strasbourg-Hautepierre
        • Principal Investigator:
          • Lauriane EBERST
  • Germany
      • Aachen, Germany, 52074
        • Not yet recruiting
        • Universitätsklinikum Aachen
        • Contact:
          • Phone Number: 00492418088400
        • Principal Investigator:
          • Elmar Stickeler
      • Berlin, Germany, 13353
        • Not yet recruiting
        • Charité Campus Virchow-Klinikum
        • Contact:
          • Phone Number: +4930450664469
        • Principal Investigator:
          • Elena Braicu
      • Bonn, Germany, 53127
        • Not yet recruiting
        • Universitätsklinikum Bonn
        • Contact:
          • Phone Number: 00492418088400
        • Principal Investigator:
          • Elmar Stickeler
      • Cologne, Germany, 50937
        • Not yet recruiting
        • Universitaetsklinikum Koeln
        • Contact:
          • Phone Number: 00492418088400
        • Principal Investigator:
          • Elmar Stickeler
      • Dresden, Germany, 01307
        • Not yet recruiting
        • Universitaetsklinikum Carl Gustav Carus Dresden
        • Principal Investigator:
          • Pauline Wimberger
        • Contact:
          • Phone Number: 00493514586728
      • Düsseldorf, Germany, 40225
        • Not yet recruiting
        • Universitaetsklinikum Duesseldorf
        • Contact:
          • Phone Number: 00492418088400
        • Principal Investigator:
          • Elmar Stickeler
      • Erlangen, Germany, 91054
        • Not yet recruiting
        • Universitaetsklinikum Erlangen
        • Principal Investigator:
          • Peter Fasching
        • Contact:
          • Phone Number: +4991318533572
      • Essen, Germany, 45136
        • Not yet recruiting
        • Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung
        • Principal Investigator:
          • Sabrina Kaiser
      • Kiel, Germany, 24105
        • Not yet recruiting
        • Universitaetsklinikum Schleswig-Holstein Campus Kiel
        • Contact:
          • Phone Number: +4943150021686
        • Principal Investigator:
          • Marion van Mackelenbergh
      • Ulm, Germany, 89075
        • Not yet recruiting
        • Universitaetsklinikum Ulm
        • Principal Investigator:
          • Sabine Heublein
  • Greece
      • Athens, Greece, 115 28
        • Not yet recruiting
        • Alexandra Hospital
        • Contact:
          • Phone Number: 302132162845
        • Principal Investigator:
          • Michalis Liontos
      • Athens, Greece, 115 28
        • Not yet recruiting
        • Aretaieio Hospital
        • Principal Investigator:
          • FLORA ZAGOURI
        • Contact:
          • Phone Number: 306946462998
      • Kalamata, Greece, 241 00
        • Not yet recruiting
        • General Hospital of Kalamata
        • Principal Investigator:
          • SOFIA STAMATOPOULOU
      • Nea Kifissia, Greece, 145 64
        • Not yet recruiting
        • General Oncology Hospital of Kifissia "Agioi Anargiroi"
        • Contact:
          • Phone Number: 00306973386584
        • Principal Investigator:
          • Roubini Zakopoulou
  • Hungary
      • Budapest, Hungary, 1122
        • Not yet recruiting
        • Orszagos Onkologiai Intezet
        • Contact:
          • Phone Number: 36309313155
        • Principal Investigator:
          • Andrea Bagameri
      • Debrecen, Hungary, 4032
        • Not yet recruiting
        • Debreceni Egyetem Klinikai Kozpont
        • Principal Investigator:
          • Robert Poka
      • Győr, Hungary, 9024
        • Not yet recruiting
        • Petz Aladar Egyetemi Oktato Korhaz
        • Principal Investigator:
          • Kofi Agyemang-Prempeh
  • Ireland
      • Cork, Ireland, T12 DC4A
        • Not yet recruiting
        • Cork University Hospital
        • Principal Investigator:
          • Dearbhaile Collins
        • Contact:
          • Phone Number: 0867969569
      • Dublin, Ireland, D04 T6F4
        • Not yet recruiting
        • St. Vincent'S University Hospital
        • Principal Investigator:
          • Lynda McSorley
      • Dublin, Ireland, D08 E9P6
        • Not yet recruiting
        • St. James's Hospital
        • Principal Investigator:
          • Karen Cadoo
  • Italy
      • Bologna, Italy, 40138
        • Not yet recruiting
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
        • Principal Investigator:
          • Claudio Zamagni
      • Catania, Italy, 95126
        • Not yet recruiting
        • Ospedale Cannizzaro
        • Contact:
          • Phone Number: 390957262708
        • Principal Investigator:
          • Giuseppa Scandurra
      • Lecce, Italy, 73100
        • Not yet recruiting
        • Ospedale Vito Fazzi
        • Principal Investigator:
          • Ugo De Giorgi
        • Contact:
          • Phone Number: 0039 0832661807
      • Lucca, Italy, 55100
        • Not yet recruiting
        • Azienda USL 2 Lucca
        • Principal Investigator:
          • Editta Baldini
        • Contact:
          • Phone Number: 39 0583 449545
      • Milan, Italy, 20133
        • Not yet recruiting
        • Fondazione IRCCS Istituto Nazionale dei Tumori
        • Principal Investigator:
          • Monika Ducceschi
      • Milan, Italy, 20141
        • Not yet recruiting
        • Istituto Europeo di Oncologia IRCCS
        • Principal Investigator:
          • Nicoletta Colombo
        • Contact:
          • Phone Number: 390257489543
      • Milan, Italy, 20159
        • Not yet recruiting
        • Ospedale Humanitas San Pio X
        • Principal Investigator:
          • Domenica Lorusso
      • Modena, Italy, 41125
        • Not yet recruiting
        • Azienda Ospedaliero Universitaria
        • Principal Investigator:
          • Cinzia Baldessari
      • Naples, Italy, 80131
        • Not yet recruiting
        • Istituto Nazionale Tumori IRCCS Fondazione Pascale
        • Principal Investigator:
          • Sabrina Cecere
      • Prato, Italy, 59100
        • Not yet recruiting
        • Nuovo Ospedale di Prato-S.Stefano
        • Principal Investigator:
          • Elena Zafarana
        • Contact:
          • Phone Number: 0574802520
      • Ravenna, Italy, 48121
        • Not yet recruiting
        • Ospedale Santa Maria delle Croci
        • Principal Investigator:
          • CLAUDIA CASANOVA
      • Roma, Italy, 00168
        • Not yet recruiting
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
        • Principal Investigator:
          • Anna Fagotti
  • Japan
      • Akashi, Japan, 673-8558
        • Not yet recruiting
        • Hyogo Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Koji Matsumoto
      • Chūōku, Japan, 104-0045
        • Not yet recruiting
        • National Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kan Yonemori
      • Fukuoka, Japan, 811-1395
        • Not yet recruiting
        • National Hospital Organization Kyushu Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kazuya Ariyoshi
      • Hidaka, Japan, 350-1298
        • Recruiting
        • Saitama Medical University International Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kosei Hasegawa
      • Kagoshima, Japan, 890-8520
        • Not yet recruiting
        • Kagoshima University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shinichi Togami
      • Kashiwa, Japan, 277-8577
        • Not yet recruiting
        • National Cancer Center Hospital East
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kenichi Harano
      • Kōtoku, Japan, 135-8550
        • Not yet recruiting
        • The Cancer Institute Hospital of JFCR
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Mayu Yunokawa
      • Nagoya, Japan, 466-8560
        • Not yet recruiting
        • Nagoya University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroaki Kajiyama
      • Niigata, Japan, 951-8566
        • Recruiting
        • Niigata Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Akira Kikuchi
      • Okayama, Japan, 700-8558
        • Recruiting
        • Okayama University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shoji Nagao
      • Otashi, Japan, 373-8550
        • Not yet recruiting
        • Gunma Prefectural Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Soichi Yamashita
      • Sapporo, Japan, 060-8648
        • Not yet recruiting
        • Hokkaido University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hidemichi Watari
      • Sendai, Japan, 980-8574
        • Recruiting
        • Tohoku University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Muneaki Shimada
      • Shiwa-gun Yahaba-cho, Japan, 028-3695
        • Not yet recruiting
        • Iwate Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tsukasa Baba
      • Suita, Japan, 565-0871
        • Recruiting
        • The University of Osaka Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kodama Michiko
      • Tsu, Japan, 514-8507
        • Not yet recruiting
        • Mie University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Eiji Kondo
      • Tōon, Japan, 791-0295
        • Not yet recruiting
        • Ehime University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tomoka Usami
  • Mexico
      • Chihuahua City, Mexico, 31207
        • Not yet recruiting
        • Scientia Investigacion Clinica S.C.
        • Contact:
          • Phone Number: 6146883416
        • Principal Investigator:
          • Enrique Zamudio Lozoya
      • Mexico City, Mexico, 11819
        • Not yet recruiting
        • Higiea Oncologia
        • Contact:
          • Phone Number: 525552731712
        • Principal Investigator:
          • Manuel Magallanes Maciel
      • Mexico City, Mexico, 03100
        • Not yet recruiting
        • Health Pharma Professional Research S.A. de C.V:
        • Principal Investigator:
          • Denisse Añorve Bailon
      • Mexico City, Mexico, 14080
        • Not yet recruiting
        • INCAN
        • Principal Investigator:
          • Claudia Cano Blanco
      • Puebla City, Mexico, 72424
        • Not yet recruiting
        • Unidad Médica Onco-hematológica
        • Principal Investigator:
          • Eduardo Tellez Bernal
        • Contact:
          • Phone Number: 52 2229478020
      • Tijuana, Mexico, 22010
        • Not yet recruiting
        • Hospital Angeles
        • Contact:
          • Phone Number: 6646351845
        • Principal Investigator:
          • Jennifer Vanessa Ramirez Puente
  • Netherlands
      • Groningen, Netherlands, 9713 GZ
        • Not yet recruiting
        • University Medical Center Groningen
        • Contact:
          • Phone Number: +31 6 55256014
        • Principal Investigator:
          • A.K.L. Reyners
      • Rotterdam, Netherlands, 3015 GD
        • Not yet recruiting
        • Erasmus Medisch Centrum
        • Contact:
          • Phone Number: 0107034897
        • Principal Investigator:
          • Ingrid Boere
  • Norway
      • Oslo, Norway, 0379
        • Not yet recruiting
        • Oslo universitetssykehus, Radiumhospitalet
        • Principal Investigator:
          • Kristina Lindemann
      • Stavanger, Norway, 4011
        • Not yet recruiting
        • Stavanger Universitetssykehus
        • Principal Investigator:
          • Elisabeth Nilsen
  • Poland
      • Bialystok, Poland, 15-276
        • Not yet recruiting
        • Uniwersytecki Szpital Kliniczny W Białymstoku
        • Principal Investigator:
          • Pawel Knapp
      • Gdansk, Poland, 80-214
        • Not yet recruiting
        • Uniwersyteckie Centrum Kliniczne
        • Principal Investigator:
          • Dagmara Klasa-Mazurkiewicz
      • Krakow, Poland, 31-501
        • Not yet recruiting
        • SP ZOZ Szpital Uniwersytecki w Krakowie
        • Principal Investigator:
          • Piotr Wysocki
      • Poznan, Poland, 61-866
        • Not yet recruiting
        • Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie
        • Principal Investigator:
          • Bartosz Urbanski
      • Siedlce, Poland, 08-110
        • Not yet recruiting
        • Mazowiecki Szpital Wojewódzki w Siedlcach
        • Principal Investigator:
          • Lubomir Bodnar
  • Romania
      • Bucharest, Romania, 013975
        • Not yet recruiting
        • Sc Mnt Healthcare Europe Srl
        • Principal Investigator:
          • Bogdan Georgescu
      • Bucharest, Romania, 013812
        • Not yet recruiting
        • SC Memorial Healthcare International SRL
        • Contact:
          • Phone Number: 40721298677
        • Principal Investigator:
          • Ingrid Iordan
      • Iași, Romania, 700483
        • Not yet recruiting
        • Institutul Regional de Oncologie
        • Contact:
          • Phone Number: 0753671616
        • Principal Investigator:
          • GEORGIANA FLORENTA
      • Timișoara, Romania, 300166
        • Not yet recruiting
        • S C Oncocenter Oncologie Clinica S R L
        • Contact:
          • Phone Number: 0040745146020
        • Principal Investigator:
          • Roxana Scheusan
  • South Korea
      • Daegu, South Korea, 42601
        • Not yet recruiting
        • Keimyung University Dongsan Hospital
        • Principal Investigator:
          • So Jin Shin
      • Goyang-si, South Korea, 10408
        • Not yet recruiting
        • National Cancer Center
        • Principal Investigator:
          • Myong Cheol Lim
      • Seongnam, South Korea, 13620
        • Not yet recruiting
        • Seoul National University Bundang Hospital
        • Principal Investigator:
          • Kidong Kim
      • Seoul, South Korea, 03080
        • Not yet recruiting
        • Seoul National University Hospital
        • Principal Investigator:
          • Jae-Weon Kim
      • Seoul, South Korea, 03722
        • Not yet recruiting
        • Severance Hospital, Yonsei University Health System
        • Principal Investigator:
          • Jung-Yun Lee
      • Seoul, South Korea, 05505
        • Not yet recruiting
        • Asan Medical Center
        • Principal Investigator:
          • Dae Yeon Kim
      • Seoul, South Korea, 06351
        • Not yet recruiting
        • Samsung Medical Center
        • Principal Investigator:
          • Chel Hun Choi
      • Suwon, South Korea, 16499
        • Not yet recruiting
        • Ajou University Hospital
        • Principal Investigator:
          • Suk Joon Chang
        • Contact:
          • Phone Number: +82-31-219-5251
  • Spain
      • Barcelona, Spain, 08028
        • Not yet recruiting
        • Hospital Universitari Dexeus
        • Contact:
          • Phone Number: 34935460139
        • Principal Investigator:
          • Alejandro Martínez Bueno
      • Castellon, Spain, 12002
        • Not yet recruiting
        • Hospital Provincial Centre de Castelló
        • Principal Investigator:
          • Nuria Ruiz Miravet
      • Granada, Spain, 18012
        • Not yet recruiting
        • Hospital Universitario Virgen Nieves
        • Contact:
          • Phone Number: +34 675304319
        • Principal Investigator:
          • Fernando Galvez Montosa
      • Madrid, Spain, 28050
        • Not yet recruiting
        • Hospital Universitario HM Sanchinarro
        • Contact:
          • Phone Number: 917567800
        • Principal Investigator:
          • Arantzazu Barquin Garcia
      • Málaga, Spain, 29010
        • Not yet recruiting
        • Hospital Universitario Virgen de la Victoria
        • Principal Investigator:
          • Marcos Iglesias Campos
      • San Sebastián de los Reyes, Spain, 28702
        • Not yet recruiting
        • Hospital Universitario Infanta Sofía
        • Contact:
          • Phone Number: 636443385
        • Principal Investigator:
          • María Merino
      • Santiago de Compostela, Spain, 15706
        • Not yet recruiting
        • CHUS - Hospital Clinico Universitario
        • Principal Investigator:
          • Juan Cueva Bañuelos
      • Toledo, Spain, 45007
        • Not yet recruiting
        • Hospital Universitario de Toledo
        • Principal Investigator:
          • María del Carmen Esteban Esteban
  • Switzerland
      • Baden, Switzerland, 5404
        • Not yet recruiting
        • Kantonsspital Baden
        • Contact:
          • Phone Number: 0792739807
        • Principal Investigator:
          • Martin Heubner
      • Bellinzona, Switzerland, 6500
        • Not yet recruiting
        • Ospedale Regionale Bellinzona e Valli
        • Principal Investigator:
          • Esteban Ciliberti
      • Chur, Switzerland, 7000
        • Not yet recruiting
        • Kantonsspital Graubünden
        • Principal Investigator:
          • Ursula Hasler-Strub
      • Geneva, Switzerland, 1211
        • Not yet recruiting
        • Hopitaux Universitaires de Geneve (HUG)
        • Principal Investigator:
          • intidhar labidi-galy
  • Taiwan
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Not yet recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Principal Investigator:
          • Hao Lin
        • Contact:
          • Phone Number: ( 0)07-7317123-8914
      • Taichung, Taiwan, 404332
        • Not yet recruiting
        • China Medical University Hospital
        • Contact:
          • Phone Number: 886-422052121 ext 2063
        • Principal Investigator:
          • Lian-Shung Yeh
      • Taichung, Taiwan, 407
        • Not yet recruiting
        • Taichung Veterans General Hospital
        • Principal Investigator:
          • Chien-Hsing Lu
      • Tainan, Taiwan, 704
        • Not yet recruiting
        • National Cheng Kung University Hospital
        • Principal Investigator:
          • Yu-Fang Huang
      • Taipei, Taiwan, 11217
        • Not yet recruiting
        • Taipei Veterans General Hospital
        • Principal Investigator:
          • Peng-Hui Wang
      • Taipei, Taiwan, 10002
        • Not yet recruiting
        • National Taiwan University Hospital
        • Contact:
          • Phone Number: 0223123456
        • Principal Investigator:
          • Lin-Hung Wei
      • Taipei, Taiwan, 10449
        • Not yet recruiting
        • Mackay Memorial Hospital
        • Principal Investigator:
          • Chih-Long Chang
      • Taoyuan, Taiwan, 333
        • Not yet recruiting
        • Chang Gung Medical Foundation-Linkou Branch
        • Principal Investigator:
          • WEI CHUN CHEN
  • United Kingdom
      • Bath, United Kingdom, BA1 3NG
        • Not yet recruiting
        • Royal United Hospitals NHS Foundation Trust
        • Principal Investigator:
          • Rebecca Bowen
      • Leeds, United Kingdom, LS9 7TF
        • Not yet recruiting
        • St James's University Hospital
        • Principal Investigator:
          • David Jackson
        • Contact:
          • Phone Number: 0113 2068336
      • London, United Kingdom, SM2 5PT
        • Not yet recruiting
        • Royal Marsden Hospital (Sutton)
        • Principal Investigator:
          • Susana Banerjee
        • Contact:
          • Phone Number: 442086613979
      • London, United Kingdom, SW3 6JJ
        • Not yet recruiting
        • Royal Marsden Hospital (Chelsea)
        • Principal Investigator:
          • Susana Banerjee
        • Contact:
          • Phone Number: 442086613979
      • Manchester, United Kingdom, M20 4BX
        • Recruiting
        • The Christie NHS Foundation Trust
        • Principal Investigator:
          • Andrew Clamp
        • Contact:
          • Phone Number: +44 161 446 3391
      • Torquay, United Kingdom, TQ2 7AA
        • Not yet recruiting
        • Torbay Hospital
        • Contact:
          • Phone Number: 01803655393
        • Principal Investigator:
          • Nangi Lo
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35233
        • Not yet recruiting
        • University of Alabama at Birmingham
        • Principal Investigator:
          • Rebecca Arend
        • Contact:
          • Phone Number: 2059344986
    • Arizona
      • Phoenix, Arizona, United States, 85016
        • Not yet recruiting
        • HonorHealth
        • Principal Investigator:
          • Lyndsay Willmott
    • California
      • Burbank, California, United States, 91505
        • Not yet recruiting
        • Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center
        • Principal Investigator:
          • Diana Pearre
        • Contact:
          • Phone Number: 8187484726
      • Duarte, California, United States, 91010
        • Not yet recruiting
        • City of Hope, Duarte
        • Principal Investigator:
          • Mihae Song
      • La Jolla, California, United States, 92093
        • Not yet recruiting
        • Moores Cancer Center
        • Principal Investigator:
          • Ramez Eskander
      • Los Angeles, California, United States, 90095
        • Not yet recruiting
        • UCLA Hematology/Oncology - Westwood (Building 100)
        • Principal Investigator:
          • Ritu Salani
        • Contact:
          • Phone Number: 310-794-3639
      • Palo Alto, California, United States, 94305
        • Not yet recruiting
        • Stanford Women's Cancer Center
        • Principal Investigator:
          • Kristin Bixel
      • San Diego, California, United States, 92120
        • Not yet recruiting
        • Kaiser Permanente Zion Medical Center
        • Principal Investigator:
          • Devansu Tewari
        • Contact:
          • Phone Number: 7143936482
      • Santa Barbara, California, United States, 93105
        • Recruiting
        • Sansum Clinic
        • Principal Investigator:
          • Eric Bank
      • Vallejo, California, United States, 94589
        • Not yet recruiting
        • Kaiser Permanente
        • Principal Investigator:
          • Juraj Kavecansky
        • Contact:
          • Phone Number: 925-295-4030
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Not yet recruiting
        • Anschutz Cancer Pavilion
        • Principal Investigator:
          • Lindsay Brubaker
      • Denver, Colorado, United States, 80210
        • Not yet recruiting
        • AdventHealth Medical Group - Porter
        • Principal Investigator:
          • Neil Phippen
    • Connecticut
      • Farmington, Connecticut, United States, 06030-8010
        • Not yet recruiting
        • UConn Health
        • Contact:
          • Phone Number: 860-679-2100
        • Principal Investigator:
          • Jennifer Jorgensen
    • Florida
      • Fort Lauderdale, Florida, United States, 33316
        • Not yet recruiting
        • Broward Health Medical Center
        • Principal Investigator:
          • Scott Jordan
      • Fort Myers, Florida, United States, 33901
        • Not yet recruiting
        • Florida Cancer Specialist- South
        • Principal Investigator:
          • Elizabeth Guancial
      • Jacksonville, Florida, United States, 32207
        • Recruiting
        • Baptist MD Anderson Cancer Center
        • Principal Investigator:
          • Lauren Hand
        • Contact:
          • Phone Number: 904.202.7300
      • Miami, Florida, United States, 33136
        • Not yet recruiting
        • University of Miami Hospital and Clinics, Sylvester Cancer Center
        • Principal Investigator:
          • Abdulrahman Sinno
      • Miami Beach, Florida, United States, 33140
        • Not yet recruiting
        • Mount Sinai Comprehensive Cancer Center
        • Principal Investigator:
          • Brian Slomovitz
        • Contact:
          • Phone Number: 954-355-4345
      • Orlando, Florida, United States, 32803
        • Not yet recruiting
        • AdventHealth Orlando
        • Principal Investigator:
          • Robert Holloway
        • Contact:
          • Phone Number: 4076228774
      • Tampa, Florida, United States, 33612
        • Not yet recruiting
        • Moffitt Cancer Center
        • Principal Investigator:
          • Hye Sook Chon
      • West Palm Beach, Florida, United States, 33401
        • Not yet recruiting
        • Florida Cancer Specialist- East
        • Principal Investigator:
          • Bradley Monk
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Not yet recruiting
        • Winship Cancer Institute, Emory University
        • Principal Investigator:
          • Beryl Manning-Geist
      • Savannah, Georgia, United States, 31405
        • Not yet recruiting
        • Nancy N. & J.C. Lewis Cancer and Research Pavillion
        • Principal Investigator:
          • Sarah Gill
    • Hawaii
      • Honolulu, Hawaii, United States, 96826
        • Not yet recruiting
        • Kapiolani Medical Center for Women and Children
        • Principal Investigator:
          • Michael Carney
    • Illinois
      • Arlington Heights, Illinois, United States, 60005
        • Recruiting
        • Illinois Cancer Specialists
        • Principal Investigator:
          • Urszula Sobol
        • Contact:
          • Phone Number: 847-259-4482
      • Chicago, Illinois, United States, 60612
        • Not yet recruiting
        • Rush University Medical Center
        • Principal Investigator:
          • Alexander Cohen
      • Chicago, Illinois, United States, 60611
        • Not yet recruiting
        • Northwestern Memorial Hospital
        • Principal Investigator:
          • Emma Barber
      • Chicago, Illinois, United States, 60637
        • Not yet recruiting
        • The University of Chicago Medicine
        • Principal Investigator:
          • Katherine Kurnit
      • Peoria, Illinois, United States, 61637
        • Not yet recruiting
        • OSF Saint Fracis Medical Center
        • Principal Investigator:
          • Michelle Rowland
    • Indiana
      • Indianapolis, Indiana, United States, 46237
        • Not yet recruiting
        • Franciscan Health
        • Principal Investigator:
          • Nibal Saad
    • Kentucky
      • Lexington, Kentucky, United States, 40503
        • Not yet recruiting
        • Baptist Health Lexington
        • Principal Investigator:
          • Hope Cottrill
        • Contact:
          • Phone Number: 8592785671
      • Louisville, Kentucky, United States, 40207
        • Not yet recruiting
        • Norton Women's and Children's Hospital
        • Principal Investigator:
          • Monica Vetter
    • Louisiana
      • New Orleans, Louisiana, United States, 70121
        • Not yet recruiting
        • Ochsner Clinic Foundation
        • Contact:
          • Phone Number: 504-842-3910
        • Principal Investigator:
          • Katrina Wade
      • Shreveport, Louisiana, United States, 71103
        • Recruiting
        • Trials 365
        • Principal Investigator:
          • Destin Black
    • Maine
      • Scarborough, Maine, United States, 04074
        • Not yet recruiting
        • Maine Medical Center - Scarborough Campus
        • Principal Investigator:
          • Leslie Bradford
    • Maryland
      • Baltimore, Maryland, United States, 21215
        • Recruiting
        • Sinai Hospital of Baltimore
        • Principal Investigator:
          • Pallavi Kumar
        • Contact:
          • Phone Number: 4106019083
      • Baltimore, Maryland, United States, 21204
        • Not yet recruiting
        • Greater Baltimore Medical Center
        • Principal Investigator:
          • Fong Liu
    • Massachusetts
      • Worcester, Massachusetts, United States, 01605
        • Not yet recruiting
        • University of Massachusetts Chan Medical School
        • Contact:
          • Phone Number: 508-334-1160
        • Principal Investigator:
          • Susan Zweizig
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Not yet recruiting
        • Karmanos Cancer Institute
        • Principal Investigator:
          • Robert Morris
      • Kalamazoo, Michigan, United States, 49007
        • Recruiting
        • West Michigan Cancer Center
        • Contact:
          • Phone Number: 269-382-2500
        • Principal Investigator:
          • Anna Hoekstra
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Not yet recruiting
        • Mayo Clinic in Rochester, Minnesota
        • Principal Investigator:
          • Saravut Weroha
    • Missouri
      • Columbia, Missouri, United States, 65212
        • Not yet recruiting
        • University of Missouri Hospital
        • Contact:
          • Phone Number: 573-882-7440
        • Principal Investigator:
          • Mark Hunter
      • Kansas City, Missouri, United States, 64132
        • Not yet recruiting
        • HCA Midwest Kansas City, MidAmerica Division, Inc.
        • Principal Investigator:
          • Alaa Elbendary
        • Contact:
          • Phone Number: 3143748491
      • Springfield, Missouri, United States, 65802
        • Not yet recruiting
        • Cox Medical Center North
        • Contact:
          • Phone Number: 417-875-3065
        • Principal Investigator:
          • Ashley Valenzuela
    • Nevada
      • Reno, Nevada, United States, 89511
        • Recruiting
        • The Center of Hope
        • Principal Investigator:
          • Peter Lim
        • Contact:
          • Phone Number: 775-327-4673
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03756
        • Not yet recruiting
        • Dartmouth-Hitchcock Medical Center
        • Principal Investigator:
          • Michael Pearl
    • New Mexico
      • Albuquerque, New Mexico, United States, 87109
        • Not yet recruiting
        • Optimum Clinical Research Group
        • Principal Investigator:
          • Karen Finkelstein
    • New York
      • Buffalo, New York, United States, 14263
        • Not yet recruiting
        • Roswell Park Cancer Institute
        • Principal Investigator:
          • Emese Zsiros
      • Lake Success, New York, United States, 11042
        • Not yet recruiting
        • Northwell Health/ RJ Zuckerberg Cancer Center
        • Principal Investigator:
          • Veena John
      • Mineola, New York, United States, 11501
        • Recruiting
        • Perlmutter Cancer Center at NYU Langone Hospital - Long Island
        • Principal Investigator:
          • Bhavana Pothuri
        • Contact:
          • Phone Number: 212-731-6455
      • New York, New York, United States, 10065
        • Recruiting
        • Memorial Sloan Kettering Cancer Center
        • Principal Investigator:
          • Roisin OCearbhaill
        • Contact:
          • Phone Number: 6468884227
      • New York, New York, United States, 10029
        • Not yet recruiting
        • Icahn School of Medicine at Mount Sinai
        • Principal Investigator:
          • Stephanie Blank
        • Contact:
          • Phone Number: 2126046059
      • New York, New York, United States, 10016
        • Recruiting
        • Laura and Isaac Perlmutter Cancer Center
        • Principal Investigator:
          • Bhavana Pothuri
        • Contact:
          • Phone Number: 212-731-6455
    • North Carolina
      • Durham, North Carolina, United States, 27710
        • Not yet recruiting
        • Duke Cancer Institute
        • Principal Investigator:
          • Angeles Secord
        • Contact:
          • Phone Number: 9196843765
    • Ohio
      • Centerville, Ohio, United States, 45459
        • Recruiting
        • Miami Valley Hospital South
        • Principal Investigator:
          • Michael Guy
        • Contact:
          • Phone Number: 937-438-7819
      • Cincinnati, Ohio, United States, 45219
        • Not yet recruiting
        • University of Cincinnati Medical Center
        • Principal Investigator:
          • Thomas Herzog
      • Cincinnati, Ohio, United States, 45242
        • Recruiting
        • Oncology Hematology Care Inc
        • Principal Investigator:
          • Ajit Gubbi
        • Contact:
          • Phone Number: 513-751-2273 x22401
      • Cleveland, Ohio, United States, 44195
        • Not yet recruiting
        • Cleveland Clinic
        • Principal Investigator:
          • Kevin Elias
        • Contact:
          • Phone Number: 216 444-6601
      • Cleveland, Ohio, United States, 44106
        • Not yet recruiting
        • University Hospitals Cleveland Medical Center
        • Principal Investigator:
          • Sarah Lynam
        • Contact:
          • Phone Number: 2168443954
      • Columbus, Ohio, United States, 43219
        • Recruiting
        • The Mark H Zangmeister Center
        • Principal Investigator:
          • Emily Whitman
      • Columbus, Ohio, United States, 43210
        • Not yet recruiting
        • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
        • Principal Investigator:
          • David O'Malley
      • Sylvania, Ohio, United States, 43560
        • Not yet recruiting
        • ProMedica Flower Hospital
        • Principal Investigator:
          • Anjalika Gandhi
    • Oregon
      • Eugene, Oregon, United States, 97401
        • Recruiting
        • USO - Oncology Associates of Oregon, P. C.
        • Principal Investigator:
          • Charles Anderson
      • Portland, Oregon, United States, 97239
        • Not yet recruiting
        • Oregon Health and Science University
        • Principal Investigator:
          • Elizabeth Munro
        • Contact:
          • Phone Number: 503-494-7999
      • Portland, Oregon, United States, 97213
        • Not yet recruiting
        • Providence Portland Medical Center
        • Principal Investigator:
          • Christopher Darus
      • Portland, Oregon, United States, 97227
        • Recruiting
        • Kaiser Permanente Interstate Medical Office Central
        • Principal Investigator:
          • Sandeep Mashru
        • Contact:
          • Phone Number: 5032493315
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19104
        • Not yet recruiting
        • University of Pennsylvania Hospital
        • Principal Investigator:
          • Lainie Martin
      • Philadelphia, Pennsylvania, United States, 19107
        • Not yet recruiting
        • Jefferson Health Honickman Center
        • Principal Investigator:
          • Mitchell Edelson
        • Contact:
          • Phone Number: 12154816069
      • Willow Grove, Pennsylvania, United States, 19090
        • Not yet recruiting
        • Asplundh Cancer Pavilion
        • Principal Investigator:
          • Mitchell Edelson
        • Contact:
          • Phone Number: 12154816069
    • Rhode Island
      • Providence, Rhode Island, United States, 02905
        • Not yet recruiting
        • Women & Infants Hospital
        • Principal Investigator:
          • Elizabeth Lokich
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Not yet recruiting
        • Medical University of South Carolina
        • Principal Investigator:
          • Brian Orr
    • Tennessee
      • Nashville, Tennessee, United States, 37232
        • Not yet recruiting
        • Vanderbilt University Medical Center
        • Principal Investigator:
          • Alaina Brown
    • Texas
      • Austin, Texas, United States, 78731
        • Recruiting
        • USO-Texas Oncology-Central/South Texas
        • Principal Investigator:
          • Lynne Knowles
      • Dallas, Texas, United States, 75390
        • Not yet recruiting
        • UT Southwestern Medical Center
        • Contact:
          • Phone Number: 214-64803026
        • Principal Investigator:
          • Jayanthi Lea
      • The Woodlands, Texas, United States, 77380
        • Recruiting
        • US Oncology
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
      • The Woodlands, Texas, United States, 77380
        • Not yet recruiting
        • US Oncology
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
      • Webster, Texas, United States, 77598-4420
        • Recruiting
        • USO - Texas Oncology Gulf Coast
        • Contact:
          • Phone Number: 281-332-7505
        • Principal Investigator:
          • Terri Pustilnik
    • Utah
      • Salt Lake City, Utah, United States, 84112
        • Not yet recruiting
        • Huntsman Cancer Institute
        • Principal Investigator:
          • Theresa Werner
        • Contact:
          • Phone Number: 8012135750
    • Washington
      • Edmonds, Washington, United States, 98026
        • Not yet recruiting
        • Swedish Cancer Institute - Edmonds
        • Principal Investigator:
          • Kristin Taylor
      • Seattle, Washington, United States, 98104
        • Not yet recruiting
        • Swedish Medical Center
        • Principal Investigator:
          • Kristin Taylor
      • Seattle, Washington, United States, 98109
        • Not yet recruiting
        • Fred Hutchinson Cancer Center
        • Principal Investigator:
          • John Liao
    • Wisconsin
      • Madison, Wisconsin, United States, 53792
        • Not yet recruiting
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Principal Investigator:
          • Janelle Sobecki

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Part A and B:

  • Have histologically confirmed high-grade serous or high-grade endometrioid ovarian, primary peritoneal, or fallopian tube cancer.
  • Have confirmed availability of tumor tissue block or slides
  • Have radiographic progression on or after most recent line of systemic anticancer therapy
  • Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
  • Have measurable disease per RECIST v1.1

Part A:

  • Have platinum-resistant disease, defined as radiographic progression less than or equal to (≤)6 months of the last administration of platinum therapy.
  • Have previously received greater than or equal to (≥)1 but ≤3 prior lines of systemic cytotoxic therapy. Up to 4 lines of prior therapy is allowed if one of those lines is mirvetuximab soravtansine.
  • Have received prior bevacizumab treatment, unless documented contraindication or intolerance.
  • Have received treatment with a poly(ADP-ribose) polymerase inhibitor (PARPi) if known to have a somatic or germline breast cancer gene (BRCA) mutation, if clinically indicated, unless documented contraindication or intolerance.

Part B:

  • Have relapsed after first-line platinum-based chemotherapy and have platinum-sensitive disease defined as radiographic progression greater than (>)6 months of their last administration of platinum therapy
  • Have previously received ≥1 but ≤2 prior lines of systemic cytotoxic chemotherapy
  • Have previously received a PARPi, per local product label, with progression on, or within 6 months of completion of PARPi treatment.

Exclusion Criteria:

Part A and B:

- Have received prior antibody-drug conjugate (ADC) with a topoisomerase inhibitor payload.

Part A:

- Have primary platinum-refractory disease, defined as disease that progressed ≤3 months since the last dose of first-line platinum-containing chemotherapy.

Part B:

- Have clinically significant proteinuria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Part A: Chemotherapy or Mirvetuximab Soravtansine (MIRV)
Investigator's Choice of Chemotherapy or MIRV given IV.
Drug: Paclitaxel
Administered IV
Drug: Gemcitabine
Administered IV
Drug: Topotecan
Administered IV
Drug: MIRV
Administered IV
Drug: Pegylated liposomal doxorubicin (PLD)
Administered IV
Experimental: Part B: LY4170156 plus Bevacizumab
Administered IV.
Drug: Bevacizumab
Administered IV
Drug: Sofetabart Mipitecan
Administered IV
Other Names:
  • LY4170156
Active Comparator: Part B: Platinum-based Doublet Chemotherapy plus Bevacizumab
Investigator's choice of platinum doublet chemotherapy IV followed by bevacizumab IV.
Drug: Paclitaxel
Administered IV
Drug: Carboplatin
Administered IV
Drug: Gemcitabine
Administered IV
Drug: Bevacizumab
Administered IV
Drug: Pegylated liposomal doxorubicin (PLD)
Administered IV
Experimental: Part A: Sofetabart Mipitecan
Administered intravenously (IV).
Drug: Sofetabart Mipitecan
Administered IV
Other Names:
  • LY4170156

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Progression-free Survival (PFS)
Time Frame: Randomization to radiographic progression or death from any cause (up to 70 months)
PFS per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Investigator
Randomization to radiographic progression or death from any cause (up to 70 months)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Overall Survival (OS)
Time Frame: Randomization to date of death from any cause (up to 70 months)
Randomization to date of death from any cause (up to 70 months)
PFS
Time Frame: Randomization to radiographic progression or death from any cause (up to 70 months)
PFS by blinded independent central review (BICR)
Randomization to radiographic progression or death from any cause (up to 70 months)
Overall Response Rate (ORR): Proportion of Participants who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR)
Time Frame: Randomization to disease progression or death (up to 70 months)
ORR per RECIST v1.1
Randomization to disease progression or death (up to 70 months)
Duration of Response (DOR)
Time Frame: Date of first documented CR or PR to date of radiographic progression or death from any cause (up to 70 months)
DOR per RECIST v1.1
Date of first documented CR or PR to date of radiographic progression or death from any cause (up to 70 months)
Disease Control Rate (DCR): Proportion of Participants who Achieve a BOR of CR, PR, or Stable Disease (SD)
Time Frame: Randomization to disease progression or death from any cause (up to 70 months)
DCR per RECIST v1.1
Randomization to disease progression or death from any cause (up to 70 months)
PFS2
Time Frame: Randomization to disease progression on next line of treatment or death from any cause (up to 70 months)
Randomization to disease progression on next line of treatment or death from any cause (up to 70 months)
Proportion of Participants with Response of Cancer Antigen-125 (CA-125) per Gynecologic Cancer Intergroup Criteria (GCIG)
Time Frame: Randomization to 30 days post treatment discontinuation
Per GCIG
Randomization to 30 days post treatment discontinuation
Percentage of Assessments with High Side-effect Bother, as measured by Functional Assessment of Cancer Therapy - General Item 5 (FACT GP5)
Time Frame: Randomization to 30 days post treatment discontinuation
FACT-GP5 is a single-item, patient-reported instrument for assessing overall treatment side-effect burden. High side effect bother is defined as a score of 3 or 4 on a 5-point Likert scale. Higher scores represent higher symptom burden.
Randomization to 30 days post treatment discontinuation
Change from Baseline in Abdominal/GI Symptoms, as measured by the European Organization for Research and Treatment of Cancer Ovarian Cancer Module (EORTC OV28)
Time Frame: Randomization to 30 days post treatment discontinuation
The EORTC OV28 consists of 28 items covering 3 functional scales and 5 symptom scales. The Abdominal/GI symptom scale ranges from 0 to 100. Higher scores indicate worse symptoms.
Randomization to 30 days post treatment discontinuation
Change from Baseline in Overall Health-related Quality of Life (HRQoL), as measured by the EORTC QLQ-C30 Global Health Status/Quality of Life Subscale
Time Frame: Randomization to 30 days post treatment discontinuation
The EORTC QLQ-C30 is a 30-question patient-reported instrument used to assess multidimensional HRQoL in cancer patients. Overall HRQoL is measured by the EORTC QLQ-30 Global Health Status/Quality of Life Subscale (two items). Response options range from 0 - 100. Higher score represents better overall HRQoL.
Randomization to 30 days post treatment discontinuation
Pharmacokinetics (PK): Minimum Blood Plasma Concentration (Cmin) of LY4170156
Time Frame: Randomization through end of treatment (up to 70 months)]
Randomization through end of treatment (up to 70 months)]
Time to Initiation of First Subsequent Systemic Anticancer Therapy or Death (TNTD)
Time Frame: Randomization to initiation of subsequent systemic anticancer or death from any cause (up to 70 months)
Randomization to initiation of subsequent systemic anticancer or death from any cause (up to 70 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Collaborators

GOG Foundation
European Network of Gynaecological Oncological Trial Groups (ENGOT)
Asia-Pacific Gynecologic Oncology Trials Group

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 22, 2025

Primary Completion (Estimated)

April 1, 2028

Study Completion (Estimated)

August 1, 2031

Study Registration Dates

First Submitted

October 7, 2025

First Submitted That Met QC Criteria

October 7, 2025

First Posted (Actual)

October 9, 2025

Study Record Updates

Last Update Posted (Actual)

May 27, 2026

Last Update Submitted That Met QC Criteria

May 26, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27727
  • J5E-MC-JZXB (Other Identifier: Eli Lilly and Company)
  • GOG-3133 (Other Identifier: Gynecologic Oncology Group)
  • ENGOT-ov97/GINECO-NOGGO (Other Identifier: European Network of Gyneaecological Oncological Trial Groups)
  • APGOT-OV17 (Other Identifier: Asia-Pacific Gynecologic Oncology Trials Group)
  • 2025-522255-25-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal should be approved by an independent review panel and researchers should sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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