A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract (FORAGER-2)

June 2, 2026 updated by: Eli Lilly and Company

FORAGER-2: A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined With Enfortumab Vedotin and Pembrolizumab in Adults With Untreated Locally Advanced or Metastatic Urothelial Carcinoma With an FGFR3 Genetic Alteration

The purpose of this study is to test a new medicine, vepugratinib, in comparison with placebo, to see if it is safe and can help people with a bladder cancer that is advanced or has spread.

Vepugratinib or placebo will be administered in combination with enfortumab vedotin and pembrolizumab.

Study participation could last up to approximately 6 years.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

450

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Contact Backup

Study Locations

  • Australia
      • Box Hill, Australia, 3128
        • Recruiting
        • Box Hill Hospital
        • Principal Investigator:
          • Iris Tung
      • Brisbane, Australia, 4101
        • Recruiting
        • Mater Misericordiae Limited
        • Principal Investigator:
          • Niara Oliveira
      • Campbelltown, Australia, 2560
        • Not yet recruiting
        • GenesisCare - Campbelltown
        • Principal Investigator:
          • Felicia Roncolato
      • Heidelberg, Australia, 3084
        • Not yet recruiting
        • Austin Health
        • Principal Investigator:
          • Andrew Weickhardt
        • Contact:
          • Phone Number: +61420381848
      • Macquarie University, Australia, 2109
        • Recruiting
        • Macquarie University
        • Principal Investigator:
          • Alison Zhang
        • Contact:
          • Phone Number: 0402856430
      • Perth, Australia, 6009
        • Not yet recruiting
        • Sir Charles Gairdner Hospital
        • Principal Investigator:
          • Rajiv Shinde
      • Randwick, Australia, 2031
        • Recruiting
        • Prince of Wales Hospital
        • Principal Investigator:
          • Elizabeth Hovey
      • St Albans, Australia, 3021
        • Recruiting
        • Western Health-Sunshine & Footscray Hospitals
        • Principal Investigator:
          • Shirley Wong
        • Contact:
          • Phone Number: 412139261
      • Waratah, Australia, 2298
        • Not yet recruiting
        • Calvary Mater Newcastle
        • Principal Investigator:
          • Lucy Corke
  • Brazil
      • Barretos, Brazil, 14784400
        • Not yet recruiting
        • Fundação Pio XII - Hospital de Câncer de Barretos
        • Principal Investigator:
          • Rodrigo Ferreira
      • Belo Horizonte, Brazil, 30180-060
        • Not yet recruiting
        • Oncocentro de Minas Gerais
        • Principal Investigator:
          • Flavio Cárcano
      • Belo Horizonte, Brazil, 30380-472
        • Not yet recruiting
        • Hospital Mario Penna
        • Principal Investigator:
          • Graziella Martins
      • Belém, Brazil, 66063-495
        • Not yet recruiting
        • CPAM - Centro de Pesquisas da Amazônia
        • Contact:
          • Phone Number: 5591999809897
        • Principal Investigator:
          • Bruno Fernandes
      • Bento Gonçalves, Brazil, 95700-084
        • Not yet recruiting
        • Hospital Tacchini
        • Principal Investigator:
          • ANDRE REIRIZ
      • Curitiba, Brazil, 80810050
        • Not yet recruiting
        • Centro Integrado de Oncologia de Curitiba
        • Contact:
          • Phone Number: 554130242421
        • Principal Investigator:
          • Karina Vianna
      • Curitiba, Brazil, 82305-100
        • Not yet recruiting
        • IOP Pesquisa
        • Principal Investigator:
          • Ronald Kool
      • João Pessoa, Brazil, 58030-080
        • Not yet recruiting
        • Centro Paraibano De Oncologia - Oncoclínicas
        • Principal Investigator:
          • Juliana Fagundes
      • Londrina, Brazil, 86015-520
        • Not yet recruiting
        • Hospital de Cancer de Londrina
        • Contact:
          • Phone Number: +55 43 3379-2771
        • Principal Investigator:
          • Mariana Kiara
      • Natal, Brazil, 59062-000
        • Not yet recruiting
        • Liga Norte Riograndense Contra o Câncer
        • Contact:
          • Phone Number: +5584991425228
        • Principal Investigator:
          • Andrea Gomes
      • Porto Alegre, Brazil, 91350-200
        • Not yet recruiting
        • Hospital Nossa Senhora da Conceição
        • Contact:
          • Phone Number: +55 51 35160954
        • Principal Investigator:
          • Gustavo Alves
      • Porto Alegre, Brazil, 90110-270
        • Not yet recruiting
        • Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
        • Contact:
          • Phone Number: 5133072943
        • Principal Investigator:
          • Alan Azambuja
      • Porto Alegre, Brazil, 90610-000
        • Not yet recruiting
        • Hospital São Lucas da PUCRS
        • Contact:
          • Phone Number: 999345922
        • Principal Investigator:
          • Mahira Rosa
      • Rio de Janeiro, Brazil, 20231-050
        • Not yet recruiting
        • Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
        • Principal Investigator:
          • pedro domingues
      • Rio de Janeiro, Brazil, 22271-110
        • Not yet recruiting
        • Instituto D'Or Pesquisa e Ensino
        • Principal Investigator:
          • Daniel Herchenhorn
      • Salvador, Brazil, 40170-110
        • Not yet recruiting
        • Nucleo de Oncologia da Bahia
        • Contact:
          • Phone Number: 557140097085
        • Principal Investigator:
          • Andre Lima
      • Salvador, Brazil, 41950-640
        • Not yet recruiting
        • Clinica Amo - Rio Vermelho
        • Contact:
          • Phone Number: 557130218735
        • Principal Investigator:
          • Augusto Mota
      • Santa Cruz do Sul, Brazil, 96830-180
        • Not yet recruiting
        • Instituto de Oncologia Saint Gallen
        • Contact:
          • Phone Number: 5551991898942
        • Principal Investigator:
          • Bianca Correa Tabajara Weiss
      • São Caetano do Sul, Brazil, 09541-270
        • Not yet recruiting
        • Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
        • Principal Investigator:
          • Suelen Martins
      • São Paulo, Brazil, 01327-001
        • Not yet recruiting
        • Hospital Alemao Oswaldo Cruz
        • Principal Investigator:
          • Ariel Kann
        • Contact:
          • Phone Number: 1135490665
      • São Paulo, Brazil, 01246-000
        • Not yet recruiting
        • Icesp - Instituto Do Câncer Do Estado de São Paulo
        • Principal Investigator:
          • Jose Mauricio Mota
        • Contact:
          • Phone Number: 55 11 3893-2709
      • São Paulo, Brazil, 01452-000
        • Not yet recruiting
        • Centro Paulista de Oncologia Clínica
        • Contact:
          • Phone Number: (17) 981090074
        • Principal Investigator:
          • Denis Leonardo Fontes Jardim
      • São Paulo, Brazil, 01321-001
        • Not yet recruiting
        • Hospital BP
        • Principal Investigator:
          • Fabio Schutz
      • São Paulo, Brazil, 04014-002
        • Not yet recruiting
        • IBCC - Núcleo de Pesquisa e Ensino
        • Contact:
          • Phone Number: 551144500360
        • Principal Investigator:
          • Felipe José Cruz
      • São Paulo, Brazil, 01209-000
        • Not yet recruiting
        • Instituto do Cancer Arnaldo Vieira de Carvalho
        • Contact:
          • Phone Number: +5511956598420
        • Principal Investigator:
          • Patricia Marubayashi
  • Canada
      • Calgary, Canada, T2N 5G2
        • Not yet recruiting
        • Arthur J.E. Child Comprehensive Cancer Centre
        • Principal Investigator:
          • Nimira Alimohamed
      • Hamilton, Canada, L8V5C2
        • Not yet recruiting
        • Hamilton Health Sciences-Juravinski Cancer Centre
        • Principal Investigator:
          • Arani Sathiyapalan
      • Québec, Canada, G1J 1Z4
        • Not yet recruiting
        • Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
        • Principal Investigator:
          • Antoine Morin Coulombe
      • Vancouver, Canada, V5Z 4E6
        • Not yet recruiting
        • BC Cancer Vancouver
        • Principal Investigator:
          • Bernhard Eigl
  • China
      • Beijing, China, 100142
        • Recruiting
        • Beijing Cancer Hospital
        • Principal Investigator:
          • Jun Guo
      • Beijing, China, 100034
        • Recruiting
        • Peking University First Hospital
        • Principal Investigator:
          • Zhisong He
        • Contact:
          • Phone Number: 010-64008229
      • Beijing, China, 100091
        • Recruiting
        • Peking University Third Hospital
        • Principal Investigator:
          • Shudong Zhang
      • Beijing, China, 102200
        • Recruiting
        • Beijing GoBroad Hospital
        • Principal Investigator:
          • Chuanliang Cui
      • Changchun, China, 100012
        • Recruiting
        • The First Hospital of Jilin University
        • Principal Investigator:
          • Ziling Liu
      • Changsha, China, 410013
        • Recruiting
        • Hunan Cancer Hospital
        • Principal Investigator:
          • Shusuan Jiang
      • Changsha, China, 410008
        • Recruiting
        • Xiangya Hospital Central South University
        • Principal Investigator:
          • minfeng chen
        • Contact:
          • Phone Number: 0731-84327918
      • Chengdu, China, 610066
        • Recruiting
        • West China Hospital, Sichuan University
        • Principal Investigator:
          • Peng Zhang
      • Chongqing, China, 400030
        • Recruiting
        • Chongqing University Cancer Hospital
        • Principal Investigator:
          • Fang Yuan
      • Chongqing, China, 400016
        • Recruiting
        • The First Affiliated Hospital of Chongqing Medical University
        • Principal Investigator:
          • Weiyang He
        • Contact:
          • Phone Number: 023-89012012
      • Guangzhou, China, 510120
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University
        • Principal Investigator:
          • Yongda Liu
        • Contact:
          • Phone Number: 13719007083
      • Guangzhou, China, 510280
        • Recruiting
        • Zhujiang Hospital
        • Principal Investigator:
          • Manming Cao
      • Guangzhou, China, 511400
        • Recruiting
        • Sun Yat-Sen University Cancer Centre
        • Principal Investigator:
          • Yanxia Shi
        • Contact:
          • Phone Number: 020-87343864
      • Hangzhou, China, 310014
        • Recruiting
        • ZheJiang Provincial People's Hospital
        • Principal Investigator:
          • xiaolong Qi
        • Contact:
          • Phone Number: 15158885167
      • Hangzhou, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital
        • Principal Investigator:
          • Jinchao Chen
      • Hangzhou, China, 310016
        • Recruiting
        • Sir Run Run Shaw Hospital
        • Principal Investigator:
          • Da Li
      • Harbin, China, 150081
        • Recruiting
        • Harbin Medical University Cancer Hospital
        • Principal Investigator:
          • Hui Chen
        • Contact:
          • Phone Number: 0451-86298104
      • Nanjing, China, 210000
        • Recruiting
        • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
        • Principal Investigator:
          • Hongqian Guo
      • Nanning, China, 530200
        • Recruiting
        • Guangxi Medical University Affiliated Tumor Hospital
        • Contact:
          • Phone Number: 15877183968
        • Principal Investigator:
          • Yong Tang
      • Ningbo, China, 315010
        • Recruiting
        • Ningbo First Hospital
        • Contact:
          • Phone Number: 15958800971
        • Principal Investigator:
          • Qi Ma
      • Shanghai, China, 200072
        • Recruiting
        • Shanghai Tenth People's Hospital
        • Principal Investigator:
          • Xudong Yao
        • Contact:
          • Phone Number: 021-66301719
      • Shanghai, China, 200040
        • Recruiting
        • Huashan Hospital, Fudan University
        • Principal Investigator:
          • Haowen Jiang
      • Shanghai, China, 200000
        • Recruiting
        • Renji Hospital Shanghai Jiao Tong University School of Medicine
        • Principal Investigator:
          • Wei Xue
        • Contact:
          • Phone Number: 862168383543
      • Tianjin, China, 300211
        • Recruiting
        • The Second Hospital Of Tianjin Medical University
        • Principal Investigator:
          • Hailong Hu
      • Wuhan, China, 430030
        • Recruiting
        • Tongji Hospital Tongji Medical,Science & Technology
        • Principal Investigator:
          • Shaogang Wang
        • Contact:
          • Phone Number: 027-83363434
  • Czechia
      • Brno, Czechia, 656 53
        • Not yet recruiting
        • Masarykuv onkologicky ustav
        • Contact:
          • Phone Number: 420 543 132 216
        • Principal Investigator:
          • Alexandr Poprach
      • Hradec Králové, Czechia, 500 05
        • Not yet recruiting
        • Fakultni nemocnice Hradec Kralove
        • Contact:
          • Phone Number: 420495832176
        • Principal Investigator:
          • Jindrich Kopecky
      • Olomouc, Czechia, 779 00
        • Not yet recruiting
        • Fakultni nemocnice Olomouc
        • Contact:
          • Phone Number: +420 588 444 717
        • Principal Investigator:
          • Hana Studentova
      • Prague, Czechia, 10034
        • Not yet recruiting
        • Fakultni nemocnice Kralovske Vinohrady
        • Contact:
          • Phone Number: 420267162837
        • Principal Investigator:
          • Jan Dvorak
      • Prague, Czechia, 14059
        • Not yet recruiting
        • Fakultni Thomayerova nemocnice
        • Principal Investigator:
          • Michaela Matouskova
        • Contact:
          • Phone Number: 420 728177828
      • Prague, Czechia, 150 06
        • Not yet recruiting
        • Fakultni nemocnice Motol
        • Contact:
          • Phone Number: 420734236410
        • Principal Investigator:
          • Tomas Buchler
  • Denmark
      • Aalborg, Denmark, 9000
        • Not yet recruiting
        • Aalborg Universitetshospital, Syd
        • Principal Investigator:
          • Andreas Carus
        • Contact:
          • Phone Number: 004597661410
      • Aarhus, Denmark, 8200
        • Not yet recruiting
        • Aarhus Universitetshospital, Skejby
        • Principal Investigator:
          • Mads Agerbaek
      • Copenhagen, Denmark, 2730
        • Not yet recruiting
        • Herlev and Gentofte Hospital
        • Contact:
          • Phone Number: 4538681079
        • Principal Investigator:
          • Line Dohn
      • Copenhagen, Denmark, 2100
        • Not yet recruiting
        • Rigshospitalet
        • Contact:
          • Phone Number: 4535458403
        • Principal Investigator:
          • Helle Pappot
      • Næstved, Denmark, 4700
        • Not yet recruiting
        • Næstved Sygehus
        • Principal Investigator:
          • Anne Sørensen
  • France
      • Angers, France, 49055
        • Not yet recruiting
        • Institut de Cancérologie de l'Ouest
        • Principal Investigator:
          • Sophie Abadie-Lacourtoisie
        • Contact:
          • Phone Number: 33241352700
      • Bordeaux, France, 33075
        • Not yet recruiting
        • CHU de Bordeaux Hop St ANDRE
        • Contact:
          • Phone Number: +33556794708
        • Principal Investigator:
          • Marine Gross-Goupil
      • Bordeaux, France, 33076
        • Not yet recruiting
        • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
        • Principal Investigator:
          • Diego Teyssonneau
      • Brest, France, 29609
        • Not yet recruiting
        • CHRU de Brest
        • Principal Investigator:
          • Benjamin Auberger
      • Caen, France, 14076
        • Not yet recruiting
        • Centre Francois Baclesse
        • Principal Investigator:
          • Florence Joly-Lobbedez
      • Lille, France, 59020
        • Not yet recruiting
        • Centre Oscar Lambret
        • Contact:
          • Phone Number: 0033 (0)320009757
        • Principal Investigator:
          • Yaovi AMELA
      • Lyon Cedex08, France, 69373
        • Not yet recruiting
        • Centre Leon Berard
        • Principal Investigator:
          • Aude Flechon
        • Contact:
          • Phone Number: 33478782643
      • Marseille, France, 13273
        • Not yet recruiting
        • Institut Paoli-Calmettes
        • Principal Investigator:
          • Gwenaelle Gravis
      • Nîmes, France, 30029
        • Not yet recruiting
        • Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carém -T
        • Principal Investigator:
          • Leticia Aptecar
      • Pierre-Bénite, France, 69310
        • Not yet recruiting
        • Centre Hospitalier Lyon Sud
        • Principal Investigator:
          • Denis Maillet
        • Contact:
          • Phone Number: 33478864324
      • Toulouse, France, 31059
        • Not yet recruiting
        • Oncopole Claudius Regaud
        • Principal Investigator:
          • Damien POUESSEL
      • Villejuif, France, 94800
        • Not yet recruiting
        • Gustave Roussy
        • Principal Investigator:
          • Yohann Loriot
        • Contact:
          • Phone Number: 33142115276
  • Germany
      • Bad Saarow, Germany, 15526
        • Not yet recruiting
        • Helios Klinikum Bad Saarow
        • Contact:
          • Phone Number: 0049 33631 73466
        • Principal Investigator:
          • Tobias Klatte
      • Bielefeld, Germany, 33611
        • Not yet recruiting
        • Evangelisches Krankenhaus Bielefeld - Johannesstift
        • Principal Investigator:
          • Florian Weissinger
        • Contact:
          • Phone Number: 052177275750
      • Bonn, Germany, 53113
        • Not yet recruiting
        • Johanniter-Krankenhaus
        • Contact:
          • Phone Number: 00492285432168
        • Principal Investigator:
          • Carsten Ohlmann
      • Cologne, Germany, 50968
        • Not yet recruiting
        • Studienzentrum Bayenthal Urologische Partnerschaft Köln
        • Contact:
          • Phone Number: 0049221362025
        • Principal Investigator:
          • Jorg Klier
      • Dresden, Germany, 01307
        • Not yet recruiting
        • Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
        • Principal Investigator:
          • Severine Banek
        • Contact:
          • Phone Number: 00493514584425
      • Duisburg, Germany, 47169
        • Not yet recruiting
        • Urologicum Duisburg Fachärztesozietät - Walsum
        • Principal Investigator:
          • Eva Hellmis
        • Contact:
          • Phone Number: +49 203 5003040
      • Düsseldorf, Germany, 40225
        • Not yet recruiting
        • Universitaetsklinikum Duesseldorf
        • Contact:
          • Phone Number: 492118119353
        • Principal Investigator:
          • Guenter Niegisch
      • Erlangen, Germany, 91054
        • Not yet recruiting
        • Universitaetsklinikum Erlangen
        • Contact:
          • Phone Number: +49 (0)9131 8223122
        • Principal Investigator:
          • Peter Goebell
      • Essen, Germany, 45122
        • Not yet recruiting
        • Universitaetsklinikum Essen
        • Principal Investigator:
          • Viktor Gruenwald
        • Contact:
          • Phone Number: +492017232637
      • Frankfurt, Germany, 60488
        • Not yet recruiting
        • Krankenhaus Nordwest GmbH
        • Contact:
          • Phone Number: 496976013917
        • Principal Investigator:
          • Inga Peters
      • Freiburg im Breisgau, Germany, 79106
        • Not yet recruiting
        • Universitaetsklinikum Freiburg
        • Principal Investigator:
          • Markus Grabbert
      • Greifswald, Germany, 17489
        • Not yet recruiting
        • Universitätsmedizin Greifswald
        • Contact:
          • Phone Number: 00493834865985
        • Principal Investigator:
          • Cindy Roennau
      • Hamburg, Germany, 20246
        • Not yet recruiting
        • Universitaetsklinikum Hamburg-Eppendorf
        • Principal Investigator:
          • Gunhild Von Amsberg
        • Contact:
          • Phone Number: 040-7410-57673
      • Heidelberg, Germany, 69120
        • Not yet recruiting
        • NCT
        • Contact:
          • Phone Number: +4962215634619
        • Principal Investigator:
          • Maximilian Jenzer
      • Koblenz, Germany, 56068
        • Not yet recruiting
        • InVO Institut für Versorgungsforschung in der Onkologie
        • Principal Investigator:
          • Christoph Lutz
        • Contact:
          • Phone Number: +49261921569325
      • Lübeck, Germany, 23538
        • Not yet recruiting
        • Universitätsklinikum Schleswig-Holstein
        • Principal Investigator:
          • Axel Merseburger
        • Contact:
          • Phone Number: 045150043691
      • Munich, Germany, 81675
        • Not yet recruiting
        • Klinikum rechts der Isar der Technischen Universität München
        • Contact:
          • Phone Number: 498941402522
        • Principal Investigator:
          • Margitta Retz
      • Münster, Germany, 48149
        • Not yet recruiting
        • Universitätsklinikum Münster - Albert Schweitzer Campus
        • Principal Investigator:
          • Martin Boegemann
      • Nuremberg, Germany, 90419
        • Not yet recruiting
        • Klinikum Nurnberg Nord
        • Contact:
          • Phone Number: + 49 911 398 3085
        • Principal Investigator:
          • Marinela Augustin
      • Nürtingen, Germany, 72622
        • Not yet recruiting
        • Studienpraxis Urologie
        • Principal Investigator:
          • Tilman Todenhöfer
        • Contact:
          • Phone Number: 4915201622246
      • Rostock, Germany, 18057
        • Not yet recruiting
        • Universitatsmedizin Rostock
        • Contact:
          • Phone Number: +49 381 494 7801
        • Principal Investigator:
          • Angelika Borkowetz
      • Tübingen, Germany, 72076
        • Not yet recruiting
        • Universitaetsklinikum Tuebingen
        • Contact:
          • Phone Number: 07071 29-87235
        • Principal Investigator:
          • Steffen Rausch
      • Ulm, Germany, 89081
        • Not yet recruiting
        • Universitaetsklinikum Ulm
        • Contact:
          • Phone Number: 4973150058036
        • Principal Investigator:
          • Friedemann Zengerling
      • Würzburg, Germany, 97080
        • Not yet recruiting
        • Universitaetsklinikum Wuerzburg
        • Principal Investigator:
          • Anna Seitz
  • Hungary
      • Budapest, Hungary, 1082
        • Not yet recruiting
        • Semmelweis Egyetem
        • Principal Investigator:
          • Peter Nyirady
      • Budapest, Hungary, 1122
        • Not yet recruiting
        • Országos Onkológiai Intézet
        • Contact:
          • Phone Number: 3612248600
        • Principal Investigator:
          • Lajos Geczi
      • Debrecen, Hungary, 4032
        • Not yet recruiting
        • Debreceni Egyetem Klinikai Kozpont
        • Contact:
          • Phone Number: 3652255840
        • Principal Investigator:
          • Peter Arkosy
      • Nyíregyháza, Hungary, 4400
        • Not yet recruiting
        • Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz
        • Principal Investigator:
          • Ágnes Wéber
        • Contact:
          • Phone Number: 003642599700 EXT 2334
      • Szeged, Hungary, 6725
        • Not yet recruiting
        • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
        • Principal Investigator:
          • Aniko Maraz
  • Italy
      • Bari, Italy, 70124
        • Not yet recruiting
        • Instituto Tumori Giovanni Paolo II
        • Contact:
          • Phone Number: +39 0805555391
        • Principal Investigator:
          • Marica Gentile
      • Milan, Italy, 20132
        • Not yet recruiting
        • Ospedale San Raffaele
        • Principal Investigator:
          • Andrea Necchi
        • Contact:
          • Phone Number: +390226435789
      • Milan, Italy, 20133
        • Not yet recruiting
        • Fondazione IRCCS Istituto Nazionale dei Tumori
        • Contact:
          • Phone Number: 0390223903028
        • Principal Investigator:
          • Giuseppe Procopio
      • Naples, Italy, 80131
        • Not yet recruiting
        • Azienda Ospedaliera Universitaria Federico II
        • Contact:
          • Phone Number: +393404166268
        • Principal Investigator:
          • Luigi Formisano
      • Padova, Italy, 35128
        • Not yet recruiting
        • Istituto Oncologico Veneto IRCCS
        • Principal Investigator:
          • Marco Maruzzo
        • Contact:
          • Phone Number: +390423732137
      • Pisa, Italy, 56126
        • Not yet recruiting
        • Azienda Ospedaliera Universitaria Pisana
        • Principal Investigator:
          • Luca Galli
      • Roma, Italy, 00168
        • Not yet recruiting
        • Fondazione Policlinico Universitario Agostino Gemelli
        • Contact:
          • Phone Number: 390630154838
        • Principal Investigator:
          • Roberto Iacovelli
      • Rome, Italy, 00144
        • Not yet recruiting
        • Istituto Nazionale Tumori Regina Elena
        • Principal Investigator:
          • Fabio Calabro
  • Japan
      • Chūōku, Japan, 104-0045
        • Recruiting
        • National Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tatsunori Shimoi
      • Fukuoka, Japan, 812-8582
        • Recruiting
        • Kyushu University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takashi Matsumoto
      • Hirosaki, Japan, 036-8563
        • Recruiting
        • Hirosaki University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shingo Hatakeyama
      • Kanazawa, Japan, 920-8641
        • Recruiting
        • Kanazawa University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiroshi Yaegashi
      • Kashiwa, Japan, 277-8577
        • Not yet recruiting
        • National Cancer Center Hospital East
        • Principal Investigator:
          • Nobuaki Matsubara
        • Contact:
          • Phone Number: 81120023812
      • Kawasaki, Japan, 216-8511
        • Recruiting
        • St. Marianna University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Eiji Kikuchi
      • Kita-ku, Japan, 761-0701
        • Recruiting
        • Kagawa University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Rikiya Taoka
      • Kobe, Japan, 650-0047
        • Recruiting
        • Kobe City Medical Center General Hospital
        • Principal Investigator:
          • Toshinari Yamasaki
        • Contact:
          • Phone Number: 81120023812
      • Kyoto, Japan, 606-8507
        • Recruiting
        • Kyoto University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Akihiro Hamada
      • Kōtoku, Japan, 135-8550
        • Recruiting
        • The Cancer Institute Hospital of JFCR
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yuji Miura
      • Matsuyama, Japan, 791-0280
        • Recruiting
        • National Hospital Organization Shikoku Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Katsuyoshi Hashine
      • Nagoya, Japan, 464-8681
        • Recruiting
        • Aichi Cancer Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hiromichi Ebi
      • Niigata, Japan, 951-8520
        • Recruiting
        • Niigata University Medical & Dental Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tsutomu Anraku
      • Osaka, Japan, 541-8567
        • Not yet recruiting
        • Osaka International Cancer Institute
        • Principal Investigator:
          • Masashi Nakayama
        • Contact:
          • Phone Number: 81120023812
      • Otashi, Japan, 373-8550
        • Recruiting
        • Gunma Prefectural Cancer Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Masaru Hasumi
      • Sapporo, Japan, 060-8648
        • Recruiting
        • Hokkaido University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Haruka Miyata
      • Sendai, Japan, 980-8574
        • Recruiting
        • Tohoku University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takuma Sato
      • Shiwa-gun Yahaba-cho, Japan, 028-3695
        • Recruiting
        • Iwate Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Wataru Obara
      • Tokushima, Japan, 770-8503
        • Recruiting
        • Tokushima University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • junya furukawa
      • Tsukuba, Japan, 305-8576
        • Recruiting
        • Tsukuba University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yoshiyuki Nagumo
  • Netherlands
      • Amsterdam, Netherlands, 1081 HV
        • Not yet recruiting
        • Amsterdam Umc, Locatie Vumc
        • Contact:
          • Phone Number: +31(0)20-4444321
        • Principal Investigator:
          • Jens Voortman
      • Breda, Netherlands, 4818 CK
        • Not yet recruiting
        • Amphia Ziekenhuis, locatie Breda Molengracht
        • Contact:
          • Phone Number: +31 76 595 5146
        • Principal Investigator:
          • Hans Westgeest
      • Nijmegen, Netherlands, 6525 GA
        • Not yet recruiting
        • Radboudumc
        • Contact:
          • Phone Number: +31 (0)24 3610353
        • Principal Investigator:
          • Mira Franken
      • Rotterdam, Netherlands, 3015 GD
        • Not yet recruiting
        • Erasmus Medisch Centrum
        • Contact:
          • Phone Number: +31618842777
        • Principal Investigator:
          • Debbie Robbrecht
  • Poland
      • Bydgoszcz, Poland, 85-048
        • Not yet recruiting
        • IN VIVO
        • Contact:
          • Phone Number: 48888455614
        • Principal Investigator:
          • Anna Krause
      • Koszalin, Poland, 75-581
        • Not yet recruiting
        • Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie
        • Contact:
          • Phone Number: 48502204953
        • Principal Investigator:
          • Mariusz Kwiatkowski
      • Krakow, Poland, 30-727
        • Not yet recruiting
        • Pratia MCM Krakow
        • Contact:
          • Phone Number: 48 505 169 040
        • Principal Investigator:
          • Anna Drosik Kwasniewska
      • Skórzewo, Poland, 60-185
        • Not yet recruiting
        • AIDPORT Sp. z o.o.
        • Principal Investigator:
          • Piotr Tomczak
      • Sosnowiec, Poland, 41-208
        • Not yet recruiting
        • GYNCENTRUM Szpital
        • Principal Investigator:
          • Sylwia Szablowska-Siwik
      • Warsaw, Poland, 02-798
        • Not yet recruiting
        • Medical Concierge Centrum Medyczne
        • Principal Investigator:
          • Piotr Radziszewski
        • Contact:
          • Phone Number: 602300992
      • Warsaw, Poland, 02-786
        • Not yet recruiting
        • WSD MEDI
        • Principal Investigator:
          • Anna Wasko Grabowska
      • Warsaw, Poland, 01-748
        • Not yet recruiting
        • Luxmed Onkologia sp. z o. o.
        • Principal Investigator:
          • Pawel Morawski
      • Warsaw, Poland, 02-781
        • Not yet recruiting
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
        • Principal Investigator:
          • Pawel Wiechno
        • Contact:
          • Phone Number: 48225462433
      • Warsaw, Poland, 04-073
        • Not yet recruiting
        • Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ
        • Principal Investigator:
          • Iwona Skoneczna
        • Contact:
          • Phone Number: 48 22 5152 591
      • Warsaw, Poland, 04-141
        • Not yet recruiting
        • Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
        • Principal Investigator:
          • Szymon Borowiec
      • Wrocaw, Poland, 50-556
        • Not yet recruiting
        • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
        • Principal Investigator:
          • Anna Kolodziej
  • South Korea
      • Goyang-si, South Korea, 10408
        • Recruiting
        • National Cancer Center
        • Principal Investigator:
          • Ho Kyung Seo
      • Junggu, South Korea, 35015
        • Recruiting
        • Chungnam National University Hospital
        • Principal Investigator:
          • Hyo Jin Lee
      • Namdong-gu, South Korea, 21565
        • Recruiting
        • Gachon University Gil Medical Center
        • Principal Investigator:
          • Joo-Hwan Park
      • Seongnam, South Korea, 13620
        • Recruiting
        • Seoul National University Bundang Hospital
        • Contact:
          • Phone Number: 820317877842
        • Principal Investigator:
          • Eun Hee Jung
      • Seoul, South Korea, 05505
        • Recruiting
        • Asan Medical Center
        • Principal Investigator:
          • Inkeun Park
        • Contact:
          • Phone Number: 82-2-3010-3266
      • Seoul, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital
        • Principal Investigator:
          • Jeonghwan Youk
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Contact:
          • Phone Number: 82222288138
        • Principal Investigator:
          • Sang Joon Shin
      • Seoul, South Korea, 06351
        • Recruiting
        • Samsung Medical Center
        • Principal Investigator:
          • Se Hoon Park
        • Contact:
          • Phone Number: 82-2-3410-3459
      • Seoul, South Korea, 06591
        • Recruiting
        • The Catholic Univ. of Korea Seoul St. Mary's Hospital
        • Principal Investigator:
          • In-Ho Kim
        • Contact:
          • Phone Number: 82-10-9056-6116
      • Seoul, South Korea, 07985
        • Recruiting
        • Ewha Womans University Mokdong Hospital
        • Principal Investigator:
          • Jungmin Jo
  • Spain
      • Badajoz, Spain, 06006
        • Not yet recruiting
        • Hospital Infanta Cristina
        • Principal Investigator:
          • Marta Gonzalez Cordero
        • Contact:
          • Phone Number: 924218040
      • Badalona, Spain, 08916
        • Not yet recruiting
        • Institut Català d'Oncologia (ICO) - Badalona
        • Principal Investigator:
          • Juan Martin Liberal
        • Contact:
          • Phone Number: 0034677254583
      • Barakaldo, Spain, 48903
        • Not yet recruiting
        • OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
        • Principal Investigator:
          • Ricardo Fernández Rodríguez
      • Barcelona, Spain, 08036
        • Not yet recruiting
        • Hospital Clinic De Barcelona
        • Principal Investigator:
          • Oscar Reig Torras
        • Contact:
          • Phone Number: 34 932275402
      • Barcelona, Spain, 08041
        • Not yet recruiting
        • Hospital De La Santa Creu I Sant Pau
        • Principal Investigator:
          • Jose Pablo Maroto Rey
        • Contact:
          • Phone Number: 34935565638
      • Barcelona, Spain, 08035
        • Not yet recruiting
        • Hospital Universitari Vall d'Hebron
        • Principal Investigator:
          • Rafael Morales Barrera
        • Contact:
          • Phone Number: 932746000 x 4350
      • Córdoba, Spain, 14004
        • Not yet recruiting
        • Hospital Universitario Reina Sofia
        • Principal Investigator:
          • MARIA JOSE MENDEZ VIDAL
      • Elche, Spain, 03202
        • Not yet recruiting
        • Hospital General Universitario de Elche
        • Principal Investigator:
          • Federico Jose Vazquez Mazon
      • Girona, Spain, 17007
        • Not yet recruiting
        • Institut Català d'Oncologia (ICO) - Girona
        • Principal Investigator:
          • Nuria Sala Gonzalez
        • Contact:
          • Phone Number: 34972225834
      • Hospitalet, Spain, 08907
        • Not yet recruiting
        • Instituto Catalán de Oncología - Hospital Duran i Reynals
        • Contact:
          • Phone Number: +34 932603261
        • Principal Investigator:
          • Irene Ortiz Rubio
      • Las Palmas de Gran Canaria, Spain, 35016
        • Not yet recruiting
        • Hospital Insular de Gran Canaria
        • Principal Investigator:
          • Alfonso Gómez de Liaño Lista
      • Madrid, Spain, 28034
        • Not yet recruiting
        • Hospital Universitario Ramon y Cajal
        • Principal Investigator:
          • Pablo Gajate Borau
        • Contact:
          • Phone Number: (+34) 913368263
      • Madrid, Spain, 28006
        • Not yet recruiting
        • Hospital La Princesa
        • Contact:
          • Phone Number: +34915202200
        • Principal Investigator:
          • Patricia Toquero Diez
      • Madrid, Spain, 28046
        • Not yet recruiting
        • Hospital Universitario La Paz
        • Contact:
          • Phone Number: 917277516
        • Principal Investigator:
          • Alvaro Pinto Marin
      • Madrid, Spain, 28033
        • Not yet recruiting
        • MD Anderson Cancer Center
        • Principal Investigator:
          • Lucrecia Ruiz
      • Madrid, Spain, 28041
        • Not yet recruiting
        • Hospital Universitario 12 de Octubre
        • Principal Investigator:
          • Daniel Castellano Gauna
        • Contact:
          • Phone Number: 0034 91 390 83 39
      • Madrid, Spain, 28040
        • Not yet recruiting
        • Hospital Clínico San Carlos
        • Principal Investigator:
          • Javier Puente Vazquez
        • Contact:
          • Phone Number: 913307545
      • Madrid, Spain, 28009
        • Not yet recruiting
        • Hospital General Universitario Gregorio Marañon
        • Contact:
          • Phone Number: 34914265238
        • Principal Investigator:
          • Jose Arranz Arija
      • Málaga, Spain, 29011
        • Not yet recruiting
        • H.R.U Málaga - Hospital General
        • Principal Investigator:
          • Alvaro Montesa Pino
        • Contact:
          • Phone Number: 951308130
      • Pamplona, Spain, 31009
        • Not yet recruiting
        • Complejo Hospitalario de Navarra
        • Contact:
          • Phone Number: 8.00 - 15.00
        • Principal Investigator:
          • Nuria Lainez Milagro
      • Pozuelo de Alarcón, Spain, 28223
        • Not yet recruiting
        • Hospital Universitario Quironsalud Madrid
        • Principal Investigator:
          • ELENA ALMAGRO CASADO
        • Contact:
          • Phone Number: +34914521987
      • Reus, Spain, 43204
        • Not yet recruiting
        • Hospital Universitari Sant Joan de Reus
        • Principal Investigator:
          • Marc Grifoll Escoda
      • Santander, Spain, 39008
        • Not yet recruiting
        • Hospital Universitario Marqués de Valdecilla
        • Principal Investigator:
          • Ignacio Duran Martinez
        • Contact:
          • Phone Number: 607552230
      • Santiago de Compostela, Spain, 15706
        • Not yet recruiting
        • CHUS - Hospital Clinico Universitario
        • Principal Investigator:
          • Urbano Anido Herranz
        • Contact:
          • Phone Number: 34981950512
      • Seville, Spain, 41013
        • Not yet recruiting
        • Hospital Universitario Virgen del Rocio
        • Principal Investigator:
          • Begona Perez Valderrama
        • Contact:
          • Phone Number: 34955013068
      • Valencia, Spain, 46015
        • Not yet recruiting
        • Hospital Arnau de Vilanova
        • Contact:
          • Phone Number: 679370073
        • Principal Investigator:
          • Jose Garcia Sanchez
  • Taiwan
      • Kaohsiung City, Taiwan, 807
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Wen-Jeng Wu
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Not yet recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Contact:
          • Phone Number: 886-972919696
        • Principal Investigator:
          • Yu-Li Su
      • Taichung, Taiwan, 404332
        • Not yet recruiting
        • China Medical University Hospital
        • Principal Investigator:
          • Chao-Hsiang Chang
        • Contact:
          • Phone Number: +886422052121
      • Taichung, Taiwan, 407
        • Not yet recruiting
        • Taichung Veterans General Hospital
        • Principal Investigator:
          • Jian-Ri Li
      • Tainan, Taiwan, 704
        • Not yet recruiting
        • National Cheng Kung University Hospital
        • Contact:
          • Phone Number: 0980971870
        • Principal Investigator:
          • Wen-Pin Su
      • Tainan, Taiwan, 71004
        • Recruiting
        • Chi Mei Medical Center
        • Principal Investigator:
          • Nai-Wen Kang
      • Tainan, Taiwan, 73657
        • Recruiting
        • Chi Mei Hospital - Liouying Branch
        • Principal Investigator:
          • Yen-Hsun Chen
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Yu-Chieh Tsai
      • Taipei, Taiwan, 11217
        • Not yet recruiting
        • Taipei Veterans General Hospital
        • Principal Investigator:
          • Yi-Hsiu Huang
        • Contact:
          • Phone Number: 886228757519-323
      • Taipei, Taiwan, 106
        • Not yet recruiting
        • National Taiwan University Cancer Center (NTUCC)
        • Principal Investigator:
          • Ying-Chun Shen
      • Taoyuan, Taiwan, 333
        • Not yet recruiting
        • Chang Gung Medical Foundation-Linkou Branch
        • Principal Investigator:
          • See-Tong Pang
        • Contact:
          • Phone Number: 886-3-3281200
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01140
        • Not yet recruiting
        • Adana Medical Park Seyhan Hastanesi
        • Contact:
          • Phone Number: 905325005269
        • Principal Investigator:
          • Ali Besen
      • Adapazarı, Turkey (Türkiye), 54100
        • Not yet recruiting
        • Sakarya University School of Medicine
        • Principal Investigator:
          • Ilhan Hacibekiroglu
        • Contact:
          • Phone Number: +90 5054785576
      • Ankara, Turkey (Türkiye), 06800
        • Not yet recruiting
        • Ankara Bilkent Sehir Hastanesi
        • Contact:
          • Phone Number: 905555306271
        • Principal Investigator:
          • Mehmet Ali Nahit Sendur
      • Ankara, Turkey (Türkiye), 06100
        • Not yet recruiting
        • Ankara University Health Practice and Research Hospitals
        • Contact:
          • Phone Number: 00903125957321
        • Principal Investigator:
          • Yuksel Urun
      • Antalya, Turkey (Türkiye), 07100
        • Not yet recruiting
        • Antalya Egitim ve Arastırma Hastanesi
        • Contact:
          • Phone Number: 905336488217
        • Principal Investigator:
          • Derya KIVRAK SALIM
      • Diyarbakır, Turkey (Türkiye), 21200
        • Not yet recruiting
        • Dicle Üniversitesi
        • Principal Investigator:
          • Muhammet kaplan
        • Contact:
          • Phone Number: 90 5337677131
      • Edirne, Turkey (Türkiye), 22030
        • Not yet recruiting
        • Trakya University
        • Contact:
          • Phone Number: 90 5334364678
        • Principal Investigator:
          • Muhammet Hacioglu
      • Gaziantep, Turkey (Türkiye), 27310
        • Not yet recruiting
        • Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
        • Contact:
          • Phone Number: 05065118207
        • Principal Investigator:
          • tulay kus
      • Istanbul, Turkey (Türkiye), 34899
        • Not yet recruiting
        • Marmara Universitesi Pendik Egitim Arastirma Hastanesi
        • Contact:
          • Phone Number: 905433389339
        • Principal Investigator:
          • Murat Sari
      • Izmir, Turkey (Türkiye), 35360
        • Not yet recruiting
        • zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
        • Contact:
          • Phone Number: 905324078648
        • Principal Investigator:
          • Ahmet Alacacioglu
      • Kadıköy, Turkey (Türkiye), 34722
        • Not yet recruiting
        • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
        • Principal Investigator:
          • Mahmut Gumus
  • United Kingdom
      • Huddersfield, United Kingdom, HD3 3EA
        • Recruiting
        • Huddersfield Royal Infirmary
        • Principal Investigator:
          • Ursula Hofmann
      • London, United Kingdom, EC1A 7BE
        • Not yet recruiting
        • St Bartholomew's Hospital
        • Principal Investigator:
          • Thomas Powles
        • Contact:
          • Phone Number: 02078828494
      • London, United Kingdom, NW1 2PG
        • Not yet recruiting
        • University College London Hospital
        • Principal Investigator:
          • Ursula McGovern
      • London, United Kingdom, SM2 5PT
        • Recruiting
        • Royal Marsden Hospital (Sutton)
        • Principal Investigator:
          • Robert Huddart
        • Contact:
          • Phone Number: +44 (0) 2086613529
      • London, United Kingdom, SW3 6JJ
        • Recruiting
        • Royal Marsden Hospital (Chelsea)
        • Principal Investigator:
          • Robert Huddart
        • Contact:
          • Phone Number: +44 (0) 2086613529
      • Manchester, United Kingdom, M20 4BX
        • Recruiting
        • The Christie NHS Foundation Trust
        • Principal Investigator:
          • Yee Pei Song
        • Contact:
          • Phone Number: 01614468409
      • Sheffield, United Kingdom, S10 2SJ
        • Not yet recruiting
        • Weston Park Hospital
        • Principal Investigator:
          • Syed Hussain
  • United States
    • Alabama
      • Huntsville, Alabama, United States, 35805
        • Recruiting
        • Clearview Cancer Institute
        • Contact:
          • Phone Number: 256-705-4224
        • Principal Investigator:
          • Marshall Schreeder
    • Arizona
      • Tucson, Arizona, United States, 85719
        • Not yet recruiting
        • The University of Arizona Cancer Center - North Campus
        • Contact:
          • Phone Number: 520-626-4703
        • Principal Investigator:
          • Alejandro Recio Boiles
    • Arkansas
      • Little Rock, Arkansas, United States, 72205
        • Not yet recruiting
        • University of Arkansas for Medical Sciences
        • Principal Investigator:
          • Anuradha kunthur
    • California
      • Irvine, California, United States, 92612
        • Not yet recruiting
        • Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine
        • Principal Investigator:
          • Nataliya Mar
      • Los Angeles, California, United States, 90024
        • Not yet recruiting
        • TRIO-US (Translational Research in Oncology-US)
        • Principal Investigator:
          • Brenda Williams
      • Los Angeles, California, United States, 90404
        • Recruiting
        • UCLA Hematology/Oncology - Santa Monica
        • Principal Investigator:
          • Alexandra Drakaki
      • Orange, California, United States, 92868
        • Not yet recruiting
        • University of California, Irvine (UCI) Health - UC Irvine Medical Center
        • Principal Investigator:
          • Nataliya Mar
      • Sacramento, California, United States, 95817
        • Not yet recruiting
        • University of California Davis (UC Davis) Comprehensive Cancer Center
        • Principal Investigator:
          • Mamta Parikh
        • Contact:
          • Phone Number: 916-734-3772
      • San Francisco, California, United States, 94158
        • Recruiting
        • UCSF Medical Center at Mission Bay
        • Principal Investigator:
          • Vadim Koshkin
        • Contact:
          • Phone Number: 773-837-0783
      • Torrance, California, United States, 90505
        • Recruiting
        • Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN)
        • Contact:
          • Phone Number: 310-750-3300
        • Principal Investigator:
          • Hugo Hool
    • Colorado
      • Denver, Colorado, United States, 80210
        • Not yet recruiting
        • AdventHealth Medical Group - Porter
        • Principal Investigator:
          • Yousuf Gaffar
        • Contact:
          • Phone Number: 303-715-7030
      • Grand Junction, Colorado, United States, 81505
        • Recruiting
        • Colorado West Healthcare System - Grand Valley Oncology
        • Contact:
          • Phone Number: 970-644-4460
        • Principal Investigator:
          • Jonathan King
    • Connecticut
      • New Haven, Connecticut, United States, 06510
        • Not yet recruiting
        • Yale-New Haven Hospital
        • Principal Investigator:
          • Joseph Kim
        • Contact:
          • Phone Number: 203-200-4822
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20010
        • Not yet recruiting
        • MedStar Washington Hospital Center
        • Principal Investigator:
          • Nicholas Simon
    • Florida
      • Orlando, Florida, United States, 32804
        • Not yet recruiting
        • AdventHealth Orlando
        • Principal Investigator:
          • Guru Sonpavde
        • Contact:
          • Phone Number: 407-303-2024
    • Idaho
      • Boise, Idaho, United States, 83712
        • Not yet recruiting
        • St. Luke's Cancer Institute: Boise
        • Principal Investigator:
          • Peyman Haghighat
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Recruiting
        • University of Illinois at Chicago
        • Principal Investigator:
          • Karine Tawagi
      • Chicago, Illinois, United States, 60637
        • Not yet recruiting
        • University of Chicago Medical Center
        • Principal Investigator:
          • Randy Sweis
        • Contact:
          • Phone Number: 773-702-1152
    • Indiana
      • Fort Wayne, Indiana, United States, 46845
        • Recruiting
        • Parkview Research Center at Parkview Regional Medical Center
        • Principal Investigator:
          • Kushal Naha
      • Indianapolis, Indiana, United States, 46202
        • Recruiting
        • Indiana University Melvin and Bren Simon Cancer Center
        • Principal Investigator:
          • Tareq Salous
      • Indianapolis, Indiana, United States, 46237
        • Recruiting
        • Franciscan Health
        • Principal Investigator:
          • Patrick Heckman
    • Kentucky
      • Lexington, Kentucky, United States, 40536
        • Suspended
        • University of Kentucky Chandler Medical Center
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70809
        • Recruiting
        • Mary Bird Perkins Cancer Center
        • Principal Investigator:
          • Victor Lin
        • Contact:
          • Phone Number: 225-215-1185
      • Metairie, Louisiana, United States, 70002
        • Not yet recruiting
        • Mary Bird Perkins Cancer Center - Metairie
        • Principal Investigator:
          • Victor Lin
        • Contact:
          • Phone Number: 225-215-1185
      • New Orleans, Louisiana, United States, 70121
        • Not yet recruiting
        • Ochsner Clinic Foundation
        • Contact:
          • Phone Number: 504-842-3910
        • Principal Investigator:
          • Brian Halbert
    • Maryland
      • Baltimore, Maryland, United States, 21287
        • Recruiting
        • Johns Hopkins Hospital
        • Principal Investigator:
          • Jean Hoffman-Censits
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Not yet recruiting
        • Massachusetts General Hospital
        • Principal Investigator:
          • Xin Gao
        • Contact:
          • Phone Number: 617-724-4000
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Not yet recruiting
        • Karmanos Cancer Institute
        • Principal Investigator:
          • Yusra Shao
      • Detroit, Michigan, United States, 48202
        • Not yet recruiting
        • Brigitte Harris Cancer Pavilion
        • Principal Investigator:
          • Muhammad Shahid
    • Missouri
      • Springfield, Missouri, United States, 65807
        • Recruiting
        • Oncology Hematology Associates
        • Contact:
          • Phone Number: 417-882-4880
        • Principal Investigator:
          • Viran Holden
      • St Louis, Missouri, United States, 63108
        • Recruiting
        • Washington University School of Medicine
        • Principal Investigator:
          • Melissa Reimers
    • Nevada
      • Las Vegas, Nevada, United States, 89148
        • Recruiting
        • Comprehensive Cancer Centers of Nevada
        • Principal Investigator:
          • Ammar Yousif
    • New Jersey
      • East Brunswick, New Jersey, United States, 08816
        • Not yet recruiting
        • Astera Cancer Care
        • Contact:
          • Phone Number: 732-390-7750
        • Principal Investigator:
          • Phillip Reid
    • New York
      • New York, New York, United States, 10065
        • Recruiting
        • Memorial Sloan Kettering Cancer Center
        • Principal Investigator:
          • Gopakumar Iyer
        • Contact:
          • Phone Number: 646-888-4737
      • New York, New York, United States, 10032
        • Not yet recruiting
        • Columbia University Irving Medical Center
        • Principal Investigator:
          • Alexander Wei
      • New York, New York, United States, 10065
        • Not yet recruiting
        • Weill Cornell Medical College
        • Principal Investigator:
          • Rohit Jain
        • Contact:
          • Phone Number: 317-217-9178
      • Rochester, New York, United States, 14642
        • Not yet recruiting
        • Wilmot Cancer Institute
        • Contact:
          • Phone Number: 585-275-4823
        • Principal Investigator:
          • Brendan Guercio
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Not yet recruiting
        • Levine Cancer Institute
        • Principal Investigator:
          • Earle Burgess
        • Contact:
          • Phone Number: 980-442-6410
      • Charlotte, North Carolina, United States, 28207
        • Recruiting
        • Oncology Specialists of Charlotte
        • Principal Investigator:
          • Nasfat Shehadeh
    • Ohio
      • Cincinnati, Ohio, United States, 45219
        • Not yet recruiting
        • University of Cincinnati Medical Center
        • Principal Investigator:
          • Robert Franklin
      • Columbus, Ohio, United States, 43210
        • Not yet recruiting
        • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
        • Principal Investigator:
          • Peng Wang
    • Oregon
      • Portland, Oregon, United States, 97213
        • Recruiting
        • Providence Portland Medical Center
        • Principal Investigator:
          • Brendan Curti
      • Portland, Oregon, United States, 97225
        • Recruiting
        • Providence St. Vincent Medical Center
        • Principal Investigator:
          • Brendan Curti
      • Portland, Oregon, United States, 97239
        • Not yet recruiting
        • Oregon Health and Science University
        • Principal Investigator:
          • Ronald Ng
      • Portland, Oregon, United States, 97227
        • Recruiting
        • Kaiser Permanente Interstate Medical Office Central
        • Principal Investigator:
          • Sandeep Mashru
        • Contact:
          • Phone Number: 503-249-3315
    • Pennsylvania
      • Lancaster, Pennsylvania, United States, 17601
        • Not yet recruiting
        • Lancaster General Hospital - Ann B Barshinger Cancer Institute
        • Principal Investigator:
          • Matthew Brennan
      • Pittsburgh, Pennsylvania, United States, 15212
        • Not yet recruiting
        • AHN Allegheny General Hospital
        • Contact:
          • Phone Number: 412-325-5700
        • Principal Investigator:
          • Shifeng Mao
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57105
        • Recruiting
        • Avera Cancer Institute- Research
        • Principal Investigator:
          • Ryan Vaca
    • Tennessee
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • Tennessee Oncology
        • Principal Investigator:
          • Kathryn Beckermann
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • Sarah Cannon Research Institute
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
      • Nashville, Tennessee, United States, 37203
        • Recruiting
        • SCRI Oncology Partners
        • Principal Investigator:
          • Benjamin Garmezy
    • Texas
      • Austin, Texas, United States, 78731
        • Recruiting
        • USO-Texas Oncology-Central/South Texas
        • Principal Investigator:
          • Michael Lattanzi
      • Baytown, Texas, United States, 77521
        • Recruiting
        • World Research Link
        • Contact:
          • Phone Number: 833-832-8328
        • Principal Investigator:
          • Amir Rasheed
      • Dallas, Texas, United States, 75390
        • Recruiting
        • UT Southwestern Medical Center
        • Principal Investigator:
          • Tian Zhang
        • Contact:
          • Phone Number: 214-648-4180
      • Dallas, Texas, United States, 75235
        • Not yet recruiting
        • Parkland Health and Hospital System
        • Principal Investigator:
          • Tian Zhang
        • Contact:
          • Phone Number: 214-648-4180
      • Houston, Texas, United States, 77030-4009
        • Not yet recruiting
        • University of Texas MD Anderson Cancer Center
        • Principal Investigator:
          • Michael Glover
      • McAllen, Texas, United States, 78504
        • Recruiting
        • Nova Oncology
        • Contact:
          • Phone Number: 281-944-3610
        • Principal Investigator:
          • Raghad Muhsin Abdul Karim, MD
      • The Woodlands, Texas, United States, 77380
        • Recruiting
        • US Oncology Research Network
        • Principal Investigator:
          • SMO Sarah Cannon Research Inst.
      • Tyler, Texas, United States, 75702
        • Recruiting
        • USO - Texas Oncology - Northeast Texas
        • Principal Investigator:
          • Donald Richards
    • Virginia
      • Norfolk, Virginia, United States, 23502
        • Recruiting
        • USO - Virginia Oncology Associates
        • Principal Investigator:
          • Mark Fleming

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have histologically confirmed, unresectable locally advanced or metastatic urothelial cancer (mUC). Individuals with mixed histology other than small cell or neuroendocrine carcinoma are eligible if a urothelial component is present.
  • Have a qualifying fibroblast growth factor receptor 3 (FGFR3) genetic alteration determined via molecular testing from a tumor or blood sample obtained at or any time after diagnosis of advanced or metastatic urothelial cancer.
  • Have measurable disease by investigator assessment defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
  • Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
  • Have adequate laboratory parameters

Exclusion Criteria:

  • Have received prior systemic therapy for locally advanced or metastatic urothelial cancer (mUC).
  • Have any unresolved toxicities greater than Grade 1 Common Terminology Criteria for Adverse Events ([CTCAE] version 5.0) from prior neoadjuvant or adjuvant systemic therapy.
  • Have ongoing sensory or motor neuropathy of Grade 2 or higher
  • Have untreated or uncontrolled central nervous system (CNS) involvement or any history of leptomeningeal disease.
  • Current evidence corneal keratopathy or retinal disorder confirmed by ocular examination at screening.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Vepugratinib + EV + Pembrolizumab (Safety Lead In)
Vepugratinib administered orally with EV + pembrolizumab administered IV
Drug: Pembrolizumab
Administered by IV infusion
Drug: Vepugratinib
Administered orally
Drug: EV
Administered by IV infusion
Experimental: Vepugratinib + Enfortumab Vedotin (EV) + Pembrolizumab
Vepugratinib administered orally, and EV + pembrolizumab administered by intravenous (IV) infusion.
Drug: Pembrolizumab
Administered by IV infusion
Drug: Vepugratinib
Administered orally
Drug: EV
Administered by IV infusion
Placebo Comparator: Placebo + EV + Pembrolizumab
Placebo administered orally, and EV + pembrolizumab administered by IV infusion.
Drug: Pembrolizumab
Administered by IV infusion
Other: Placebo
Administered orally
Drug: EV
Administered by IV infusion

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of participants with treatment-related adverse events related to vepugratinib in combination with EV and pembrolizumab
Time Frame: From baseline up to 90 months
From baseline up to 90 months
Safety Lead-in: Overall Response Rate (ORR)
Time Frame: From baseline up to 90 months
ORR by Investigator Assessment.
From baseline up to 90 months
Progression-free Survival (PFS)
Time Frame: Baseline to Study Completion (estimated as 6 years)
PFS by blinded independent committee review (BICR).
Baseline to Study Completion (estimated as 6 years)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Safety Lead-in: Disease Control Rate (DCR)
Time Frame: From baseline up to the end of Cycle 2 (each Cycle is 21 days)
DCR by investigator assessment.
From baseline up to the end of Cycle 2 (each Cycle is 21 days)
Safety Lead-in: Time to Response (TTR)
Time Frame: From baseline up to 90 months
TTR by investigator assessment.
From baseline up to 90 months
Overall Survival (OS)
Time Frame: Baseline to Study Completion (estimated as 6 years)
Baseline to Study Completion (estimated as 6 years)
Objective Response Rate (ORR) by BICR
Time Frame: Baseline to Study Completion (estimated as 6 years)
Baseline to Study Completion (estimated as 6 years)
Duration of Response (DoR)
Time Frame: Baseline to Study Completion (estimated as 6 years)
DOR by BICR.
Baseline to Study Completion (estimated as 6 years)
Progression-free Survival (PFS)
Time Frame: Baseline to Study Completion (estimated as 6 years)
PFS by investigator assessment.
Baseline to Study Completion (estimated as 6 years)
Objective Response Rate (ORR)
Time Frame: Baseline to Study Completion (estimated as 6 years)
Percentage of Participants who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR)ORR by investigator assessment
Baseline to Study Completion (estimated as 6 years)
Duration of Response (DOR)
Time Frame: Baseline to Study Completion (estimated as 6 years)
DOR by investigator assessment.
Baseline to Study Completion (estimated as 6 years)
Progression-free Survival 2 (PFS2)
Time Frame: Baseline to Study Completion (estimated as 6 years)
PFS2 by investigator assessment.
Baseline to Study Completion (estimated as 6 years)
Plasma Concentrations of Vepugratinib
Time Frame: Cycle 1 Day 1 to Study completion (estimated as 90 months)
PK samples are to be drawn every odd cycle while participant on study.
Cycle 1 Day 1 to Study completion (estimated as 90 months)
Change from Baseline in Global Health Status/Quality of Life (QOL) and Physical Function Measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)
Time Frame: Baseline to Study Completion (estimated as 6 years)
The EORTC QLQ-C30 is a validated self-reported general cancer questionnaire consisting of 30 items with a recall of the past 7 days. Response options range from 1) "very poor" to 7) "excellent." Higher scores represent better overall HRQoL.
Baseline to Study Completion (estimated as 6 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 12, 2025

Primary Completion (Estimated)

October 1, 2029

Study Completion (Estimated)

May 1, 2033

Study Registration Dates

First Submitted

October 9, 2025

First Submitted That Met QC Criteria

October 16, 2025

First Posted (Actual)

October 20, 2025

Study Record Updates

Last Update Posted (Actual)

June 3, 2026

Last Update Submitted That Met QC Criteria

June 2, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27333
  • J4G-MC-JZVD (Other Identifier: Eli Lilly and Company)
  • 2025-522855-25-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal should be approved by an independent review panel and researchers should sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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