Detection of Microplastics in Patients With Periodontitis (micropl_perio)

November 16, 2025 updated by: Hady Haririan, Sigmund Freud PrivatUniversitat

Detection of Microplastics in Patients With Periodontitis - a Cross-sectional Study

Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Patients with periodontitis, stage 3 or 4, with a full mouth probing score at the Department of Periodontology, Dental Clinics, Sigmund Freud University, Vienna, Austria

Description

Inclusion Criteria:

  • Adults aged 18 and over
  • Gender: Female / male / diverse

  • Patients

    • who have been diagnosed with stage III and IV periodontitis.
    • who have not yet started periodontal treatment.
    • who still have at least 20 teeth. Providing written consent to participate in the study.

Exclusion Criteria:

  • Patients

    • who have already been treated for periodontitis
    • who have already undergone/begun periodontitis treatment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
patients with periodontitis, stage 3 or 4
Status assessment with supragingival cleaning Sample collection with sterile universal curette (steel) from the bottom of the pockets of the 4 deepest gum pockets (ST >= 5mm) pooled in ultrapure water

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Microplastics
Time Frame: one year
number of patients with periodontitis with microplastics in periodontal pockets, quantification of microplastic particles in periodontal pockets, qualitative analysis of microplastic
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sigmund Freud PrivatUniversitat

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 1, 2026

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2028

Study Registration Dates

First Submitted

November 13, 2025

First Submitted That Met QC Criteria

November 13, 2025

First Posted (Estimated)

November 17, 2025

Study Record Updates

Last Update Posted (Actual)

November 19, 2025

Last Update Submitted That Met QC Criteria

November 16, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 17538733
  • SFU (Other Grant/Funding Number: SFU)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

microplastic findings

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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