A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes (ENLIGHTEN-2)

August 20, 2026 updated by: Eli Lilly and Company

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1035

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 317-615-4559
  • Email: LillyTrials@Lilly.com

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1419AHN
        • Not yet recruiting
        • Asociacion de Beneficencia Hospital Sirio Libanes
        • Contact:
          • Phone Number: 541145740870
        • Principal Investigator:
          • Gustavo Frechtel
      • Buenos Aires, Argentina, C1128AAF
        • Not yet recruiting
        • Mautalen Salud e investigación
        • Contact:
          • Phone Number: 541145143400
        • Principal Investigator:
          • Jose Fretes
      • Buenos Aires, Argentina, C1056ABI
        • Not yet recruiting
        • Centro de Investigaciones Metabólicas (CINME)
        • Principal Investigator:
          • Federico Perez Manghi
        • Contact:
          • Phone Number: 08003450697
      • Buenos Aires, Argentina, C1056ABH
        • Not yet recruiting
        • Investigaciones Medicas Imoba Srl
        • Principal Investigator:
          • Silvia Orio
        • Contact:
          • Phone Number: 541160884234
      • Buenos Aires, Argentina, C1023AAB
        • Not yet recruiting
        • STAT Research S.A.
        • Principal Investigator:
          • Lucas Gutnisky
        • Contact:
          • Phone Number: (54 11) 48166733
      • Buenos Aires, Argentina, C1425AGC
        • Not yet recruiting
        • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
        • Contact:
          • Phone Number: 5401148019001
        • Principal Investigator:
          • Evelyn Blanc
      • CABA, Argentina, 1204
        • Not yet recruiting
        • Instituto Centenario
        • Principal Investigator:
          • SUSANA SALZBERG
        • Contact:
          • Phone Number: 5491121559419
      • Córdoba, Argentina, 5000
        • Not yet recruiting
        • Centro Diabetológico Dr. Waitman
        • Principal Investigator:
          • Silvana Ernestina Solis
        • Contact:
          • Phone Number: 54 9 351 4245162
      • Granadero Baigorria, Argentina, 2152
        • Not yet recruiting
        • Centro de Investigaciones Clínicas Baigorria
        • Principal Investigator:
          • Maximiliano Sicer
        • Contact:
          • Phone Number: 54 9 3413 34-8021
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • Instituto Médico Catamarca IMEC
        • Contact:
          • Phone Number: 3416176661
        • Principal Investigator:
          • Natacha Maldonado
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • Fundacion Estudios Clinicos
        • Contact:
          • Phone Number: 543412384171
        • Principal Investigator:
          • María Schiavoni
  • China
      • Beijing, China, 100034
        • Recruiting
        • Peking University People's Hospital
        • Contact:
          • Phone Number: 13910978815
        • Principal Investigator:
          • Linong Ji
      • Beijing, China, 101200
        • Recruiting
        • Beijing Pinggu District Hospital
        • Contact:
          • Phone Number: 13911080328
        • Principal Investigator:
          • yufeng li
      • Beijing, China, 100000
        • Recruiting
        • Luhe Hospital
        • Principal Investigator:
          • Dong Zhao
      • Chengdu, China, 610072
        • Recruiting
        • Sichuan Provincial People's Hospital
        • Principal Investigator:
          • Limin Tian
      • Chongqing, China, 400010
        • Recruiting
        • The Second Affiliated Hospital Chongqing Medical University
        • Principal Investigator:
          • Dongfang Liu
        • Contact:
          • Phone Number: 13594028475
      • Guangzhou, China, 510280
        • Recruiting
        • Zhujiang Hospital
        • Principal Investigator:
          • Jia Sun
      • Hefei, China, 230011
        • Recruiting
        • The Second People's Hospital of Hefei
        • Principal Investigator:
          • Jun Ye
        • Contact:
          • Phone Number: 86-13956099720
      • Jinan, China, 250013
        • Recruiting
        • Jinan Central Hospital
        • Principal Investigator:
          • Nianrong Mi
      • Luoyang Shi, China, 471023
        • Recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Principal Investigator:
          • Hongwei Jiang
        • Contact:
          • Phone Number: 13653880139
      • Nanchang, China, 330038
        • Recruiting
        • Jiangxi Provincial People's Hospital
        • Principal Investigator:
          • Zongyou Cheng
        • Contact:
          • Phone Number: 13767035719
      • Nanjing, China, 210011
        • Recruiting
        • The Second Affiliated Hospital of Nanjing Medical University
        • Principal Investigator:
          • Yibing Lu
        • Contact:
          • Phone Number: 18951762960
      • Nanjing, China, 210006
        • Recruiting
        • Nanjing First Hospital
        • Principal Investigator:
          • Qian Li
      • Nanjing, China, 210008
        • Recruiting
        • Jiangsu Province Official Hospital
        • Principal Investigator:
          • Wei Tang
      • Shanghai, China, 201800
        • Recruiting
        • Jiading District Central Hospital
        • Principal Investigator:
          • Lixia Suo
      • Tianjin, China, 300211
        • Recruiting
        • The Second Hospital Of Tianjin Medical University
        • Principal Investigator:
          • Yu Chen
      • Zigong, China, 643000
        • Recruiting
        • Zigong First People's Hospital
        • Principal Investigator:
          • Jian Li
  • Czechia
      • Krnov, Czechia, 79401
        • Active, not recruiting
        • MUDr. Tomas Edelsberger
      • Ostrava, Czechia, 702 00
        • Active, not recruiting
        • MUDr. Miroslav Koliba s.r.o.
      • Prague, Czechia, 110 00
        • Active, not recruiting
        • MUDr. Jana Parkanyiova
      • Prague, Czechia, 11000
        • Active, not recruiting
        • Diabet2 s.r.o., diabetologicka a interni ambulance
  • Germany
      • Berlin, Germany, 13187
        • Active, not recruiting
        • Diabetespraxis Dr. Braun
      • Bünde, Germany, 32257
        • Active, not recruiting
        • Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
      • Essen, Germany, 45136
        • Active, not recruiting
        • InnoDiab Forschung GmbH
      • Hamburg, Germany, 21109
        • Active, not recruiting
        • Diabetes Zentrum Wilhelmsburg
      • Münster, Germany, 48145
        • Active, not recruiting
        • Institut für Diabetesforschung GmbH Münster
      • Münster, Germany, 48153
        • Active, not recruiting
        • Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage
      • Oldenburg, Germany, 23758
        • Active, not recruiting
        • RED-Institut GmbH
  • India
      • Bangalore, India, 560092
        • Suspended
        • Life Care Hospital and Research Centre
      • Belgavi, India, 590019
        • Suspended
        • Belagavi Institute of Medical Sciences - Belagavi
      • Lucknow, India, 226010
        • Suspended
        • Dr. Ram Manohar Lohia Institute of Medical Sciences
      • Nagpur, India, 441108
        • Suspended
        • All India Institute of Medical Sciences (AIIMS) - Nagpur
      • Pune, India, 411057
        • Suspended
        • Lifepoint Multispeciality Hospital
      • Ulhasnagar, India, 421004
        • Suspended
        • Ashirwad Hospital and Research Centre
  • Japan
      • Chigasaki, Japan, 253-0044
        • Recruiting
        • Hayashi Diabetes Internal Medicine Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tsutomu Hayashi
      • Chūōku, Japan, 103-0027
        • Recruiting
        • Tokyo-Eki Center-building Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Arihiro Kiyosue
      • Kamakura, Japan, 247-0055
        • Recruiting
        • Shonan Takai Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kuninobu Takai
      • Kasuya-gun, Japan, 811-2310
        • Recruiting
        • Oishi Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yayoi Oishi
      • Kawaguchi, Japan, 332-0015
        • Recruiting
        • OHAMA Diabetes Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Toshihiko Ohama
      • Kita-ku, Japan, 114-0001
        • Recruiting
        • Higashijujo Sakai Diabetes Internal Medicine Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Koji Sakai
      • Mihama-ku,Chiba City, Japan, 261-0004
        • Recruiting
        • Tokuyama Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takahiko Tokuyama
      • Naha, Japan, 900-0015
        • Recruiting
        • Shinkenko Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yoshiki Shiohira
      • Oyama, Japan, 323-0022
        • Recruiting
        • Oyama East Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kunihiro Suzuki
      • Setagaya-ku, Japan, 155-0031
        • Recruiting
        • Shimokitazawa Tomo Clinic
        • Principal Investigator:
          • Tomofumi Murakami
        • Contact:
          • Phone Number: 81120023812
      • Sōka, Japan, 340-0015
        • Recruiting
        • Soka Sugiura Internal Medicine Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tatsushi Sugiura
      • Tsuchiura, Japan, 300-0012
        • Recruiting
        • Tsuchiura Medical & Health Care Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Natsuki Imoto
      • Tsuchiura, Japan, 300-0062
        • Recruiting
        • Tsuchiura Beryl Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kota Yamada
      • Ushiku, Japan, 300-1207
        • Recruiting
        • Nagase Diabetes Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Terumasa Nagase
      • Yokohama, Japan, 232-0064
        • Recruiting
        • Yokohama Minoru Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Chino Nakamura
  • Mexico
      • Guadalajara, Mexico, 44670
        • Not yet recruiting
        • Unidad de Investigación Clínica y Atención Médica HEPA S.C.
        • Contact:
          • Phone Number: 523336422886
        • Principal Investigator:
          • Marisol Herrera Marmolejo
      • Guadalajara, Mexico, 44260
        • Not yet recruiting
        • Centro de Investigacion Medica de Occidente, S.C.
        • Contact:
          • Phone Number: 523312044280
        • Principal Investigator:
          • Emilia Pelayo Orozco
      • Guadalajara, Mexico, 44600
        • Not yet recruiting
        • Instituto Jalisciense de Investigacion en Diabetes y Obesidad
        • Principal Investigator:
          • Guillermo Gonzalez Galvez
        • Contact:
          • Phone Number: +523336153477
      • Monterrey, Mexico, 64060
        • Not yet recruiting
        • Cardiolink Clin Trials
        • Contact:
          • Phone Number: 8140401554
        • Principal Investigator:
          • Elías Alberto García Cantú
      • Mérida, Mexico, 97070
        • Not yet recruiting
        • Medical Care and Research SA de CV
        • Contact:
          • Phone Number: 9992211846
        • Principal Investigator:
          • José Cetina Canto
  • Poland
      • Bialystok, Poland, 15445
        • Recruiting
        • Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
        • Contact:
          • Phone Number: 48856520318
        • Principal Investigator:
          • Grazyna Laszewska
      • Bydgoszcz, Poland, 85-163
        • Recruiting
        • Centrum Medyczne Neuromed
        • Contact:
          • Phone Number: 48696268565
        • Principal Investigator:
          • Beata Lisewska
      • Elblag, Poland, 82-300
        • Recruiting
        • Ambulatorium sp. z o.o.
        • Contact:
          • Phone Number: 48608202021
        • Principal Investigator:
          • Anna Bazela-Ostromecka
      • Krakow, Poland, 31-261
        • Recruiting
        • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
        • Contact:
          • Phone Number: 48126237122
        • Principal Investigator:
          • Joanna Mirocka
      • Lodz, Poland, 90-338
        • Recruiting
        • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
        • Contact:
          • Phone Number: 607536360
        • Principal Investigator:
          • Malgorzata Jozefowska
      • Lublin, Poland, 20-718
        • Recruiting
        • Ekamed
        • Principal Investigator:
          • Ewa Skokowska
        • Contact:
          • Phone Number: 48603787884
      • Ruda Śląska, Poland, 41-709
        • Recruiting
        • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
        • Contact:
          • Phone Number: 48728814934
        • Principal Investigator:
          • Henryk Rudzki
      • Zabrze, Poland, 41-800
        • Recruiting
        • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
        • Principal Investigator:
          • Janusz Gumprecht
        • Contact:
          • Phone Number: 48 32 271 25 11
  • Puerto Rico
      • Caguas, Puerto Rico, 00725
        • Recruiting
        • Centro de Endocrinologia y Nutricion
        • Contact:
          • Phone Number: 7877467057
        • Principal Investigator:
          • Juan Otero-Martinez
      • Dorado, Puerto Rico, 00646
        • Recruiting
        • Dorado Medical Complex
        • Principal Investigator:
          • Luis Pagan-Cardona
        • Contact:
          • Phone Number: 787-278-1576
  • Slovakia
      • Bratislava, Slovakia, 83101
        • Recruiting
        • Diacrin s.r.o.
        • Contact:
          • Phone Number: 00421908956445
        • Principal Investigator:
          • Eva Zakovicova
      • Malacky, Slovakia, 901 01
        • Recruiting
        • MediVet s.r.o.
        • Contact:
          • Phone Number: 00421905565208
        • Principal Investigator:
          • Eva Pavleova
      • Nové Zámky, Slovakia, 940 02
        • Recruiting
        • FUNKYSTUFF s.r.o.
        • Principal Investigator:
          • Miriam Teplanova
        • Contact:
          • Phone Number: 421 35 6420 746
      • Námestovo, Slovakia, 02901
        • Recruiting
        • B-Medical, s.r.o.
        • Principal Investigator:
          • Maria Balekova
        • Contact:
          • Phone Number: 421948014007
      • Púchov, Slovakia, 020 01
        • Recruiting
        • DIA-MED CENTRUM s.r.o.
        • Contact:
          • Phone Number: 421423810145
        • Principal Investigator:
          • Ludmila Kubincova
      • Sabinov, Slovakia, 083 01
        • Recruiting
        • MEDI-DIA s.r.o.
        • Contact:
          • Phone Number: 421907230520
        • Principal Investigator:
          • Martina Merciakova
  • South Korea
      • Ansan-si, South Korea, 15355
        • Recruiting
        • Korea University Ansan Hospital
        • Contact:
          • Phone Number: 82314124274
        • Principal Investigator:
          • NANHEE KIM
      • Guri-si, South Korea, 11923
        • Recruiting
        • Hanyang University Guri Hospital
        • Principal Investigator:
          • Chang Beom Lee
      • Gwangju, South Korea, 61453
        • Recruiting
        • Chosun university hospital
        • Principal Investigator:
          • Sang Yong Kim
      • Seongnam, South Korea, 13620
        • Recruiting
        • Seoul National University Bundang Hospital
        • Principal Investigator:
          • Soo Lim
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System
        • Principal Investigator:
          • Byung Wan Lee
  • Spain
      • Alzira, Spain, 46600
        • Active, not recruiting
        • Hospital Universitario de La Ribera
      • Barcelona, Spain, 08036
        • Active, not recruiting
        • Hospital Clinic de Barcelona
      • Barcelona, Spain, 08035
        • Active, not recruiting
        • Hospital Universitari Vall d'Hebron
      • Madrid, Spain, 28006
        • Active, not recruiting
        • Complejo Hospitalario Ruber Juan Bravo
      • Málaga, Spain, 29010
        • Active, not recruiting
        • Hospital Universitario Virgen de la Victoria
      • Málaga, Spain, 29009
        • Active, not recruiting
        • H.R.U Málaga - Hospital Civil
      • Santiago de Compostela, Spain, 15702
        • Active, not recruiting
        • Centro Médico Compostela
      • Seville, Spain, 41013
        • Active, not recruiting
        • Hospital Universitario Virgen del Rocío
      • Seville, Spain, 41950
        • Active, not recruiting
        • Vithas Hospital Sevilla
  • Taiwan
      • Kaohsiung City, Taiwan, 807
        • Recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Tsung-Hsien Lin
        • Contact:
          • Phone Number: 886-7-3121101 ext 7741
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Principal Investigator:
          • Jung-Fu Chen
        • Contact:
          • Phone Number: +886912159389
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chih-Yuan Wang
        • Contact:
          • Phone Number: 0223123456
      • Taipei, Taiwan, 11217
        • Recruiting
        • Taipei Veterans General Hospital
        • Contact:
          • Phone Number: 886228757516
        • Principal Investigator:
          • Chii-Min Hwu
      • Taoyuan, Taiwan, 333
        • Recruiting
        • Chang Gung Medical Foundation-Linkou Branch
        • Principal Investigator:
          • Chia-Hung Lin
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35209
        • Recruiting
        • Birmingham Clinical Research
        • Principal Investigator:
          • Nova Law
        • Contact:
          • Phone Number: 205-870-4343
      • Cullman, Alabama, United States, 35055
        • Recruiting
        • Cullman Clinical Trials
        • Principal Investigator:
          • Randall Quinn
        • Contact:
          • Phone Number: 256-708-2826
    • Arizona
      • Tucson, Arizona, United States, 85712
        • Recruiting
        • Tucson Clinical Research Institute
        • Principal Investigator:
          • Girish Karamchandani
    • California
      • Canoga Park, California, United States, 91304
        • Recruiting
        • San Fernando Valley Health Institute
        • Principal Investigator:
          • Jeffrey London
        • Contact:
          • Phone Number: 818-222-6868
      • Escondido, California, United States, 92025
        • Recruiting
        • AMCR Institute
        • Contact:
          • Phone Number: 760-466-1520
        • Principal Investigator:
          • Jenine Stone
      • Greenbrae, California, United States, 94904
        • Recruiting
        • NorCal Medical Research, Inc
        • Contact:
          • Phone Number: 415-461-1585
        • Principal Investigator:
          • Linda Gaudiani
      • Long Beach, California, United States, 90815
        • Recruiting
        • Ark Clinical Research
        • Principal Investigator:
          • Martha Navarro
      • Los Alamitos, California, United States, 90720
        • Recruiting
        • Pacific Clinical Studies
        • Principal Investigator:
          • Etsegenet Ayele
        • Contact:
          • Phone Number: 562-598-0600 ext 205
      • Los Angeles, California, United States, 90056
        • Recruiting
        • Inglewood Clinical
        • Principal Investigator:
          • Maricor Grio
        • Contact:
          • Phone Number: 310-693-5000
      • Santa Clarita, California, United States, 91321
        • Recruiting
        • Care Access - Santa Clarita
        • Principal Investigator:
          • Sina Tebi
        • Contact:
          • Phone Number: 661-371-7272
      • Spring Valley, California, United States, 91978
        • Recruiting
        • Encompass Clinical Research
        • Contact:
          • Phone Number: 619-660-9068
        • Principal Investigator:
          • Hanid Audish
      • Walnut Creek, California, United States, 94598
        • Recruiting
        • Diablo Clinical Research, Inc.
        • Contact:
          • Phone Number: 925-930-7267
        • Principal Investigator:
          • Bonnie Kimmel
    • Colorado
      • Aurora, Colorado, United States, 80012
        • Recruiting
        • Care Access - Aurora
        • Principal Investigator:
          • Mauricio Waintrub
        • Contact:
          • Phone Number: 720-368-4865
    • Connecticut
      • Bridgeport, Connecticut, United States, 06606
        • Recruiting
        • New England Research Associates, LLC
        • Contact:
          • Phone Number: 203-374-9816
        • Principal Investigator:
          • Ilja Hulinsky
      • Hamden, Connecticut, United States, 06517
        • Recruiting
        • CMR of Greater New Haven, LLC
        • Principal Investigator:
          • Jillian Reid
    • Florida
      • Daytona Beach, Florida, United States, 32117
        • Recruiting
        • Arrow Clinical Trials
        • Principal Investigator:
          • David Billmeier
        • Contact:
          • Phone Number: 386-278-8000
      • Delray Beach, Florida, United States, 33484
        • Recruiting
        • Care Access - Delray Beach
        • Principal Investigator:
          • Sudhir Bansal
        • Contact:
          • Phone Number: 401-773-7855
      • Fleming Island, Florida, United States, 32003
        • Recruiting
        • Fleming Island Center for Clinical Research
        • Principal Investigator:
          • Jennifer Sidey
        • Contact:
          • Phone Number: 904-621-0390
      • Inverness, Florida, United States, 34452
        • Recruiting
        • Nature Coast Clinical Research - Inverness
        • Principal Investigator:
          • Paul Hellstern
        • Contact:
          • Phone Number: 352-341-2100
      • Jacksonville, Florida, United States, 32216
        • Recruiting
        • Jacksonville Center for Clinical Research
        • Contact:
          • Phone Number: 904-730-0101
        • Principal Investigator:
          • Jeffry Jacqmein
      • Miami, Florida, United States, 33165
        • Recruiting
        • New Horizon Research Center
        • Principal Investigator:
          • Lazaro Nunez
        • Contact:
          • Phone Number: 305-226-3933
      • Miami, Florida, United States, 33138
        • Recruiting
        • Flourish Research Acquisition, LLC dba Flourish Research - North Miami
        • Principal Investigator:
          • Rimsky Denis
        • Contact:
          • Phone Number: 786-772-0411
      • Mt. Dora, Florida, United States, 32757
        • Recruiting
        • Adult Medicine of Lake County, Inc.
        • Principal Investigator:
          • Shirley Nagel
        • Contact:
          • Phone Number: 352-383-8222
      • Pembroke Pines, Florida, United States, 33027
        • Recruiting
        • American Research Centers of Florida
        • Principal Investigator:
          • Luis del Prado Rodriguez
        • Contact:
          • Phone Number: 954-237-3799
      • Winter Park, Florida, United States, 32789
        • Recruiting
        • Clinical Site Partners, LLC dba Flourish Research
        • Contact:
          • Phone Number: 407-740-8078
        • Principal Investigator:
          • Monica Aggarwal
    • Georgia
      • Dunwoody, Georgia, United States, 30338
        • Recruiting
        • Teak Research Consults - Dunwoody
        • Contact:
          • Phone Number: 470-403-4755
        • Principal Investigator:
          • Aakar Thaker
      • Lawrenceville, Georgia, United States, 30043
        • Recruiting
        • Teak Research Consults
        • Principal Investigator:
          • Kamar Alabi
      • Macon, Georgia, United States, 31210
        • Recruiting
        • The Jones Center Clinical Research
        • Principal Investigator:
          • Susan Garcia Castillo
    • Hawaii
      • Honolulu, Hawaii, United States, 96817
        • Recruiting
        • Pacific Diabetes & Endocrine Center
        • Contact:
          • Phone Number: 808-526-0303
        • Principal Investigator:
          • ALAN PARSA
    • Illinois
      • Skokie, Illinois, United States, 60077
        • Recruiting
        • NorthShore University Health System
        • Contact:
          • Phone Number: 847-663-8540
        • Principal Investigator:
          • Liana Billings
    • Indiana
      • Indianapolis, Indiana, United States, 46254
        • Recruiting
        • DM Clinical Research - Indianapolis
        • Principal Investigator:
          • Brandon Essink
        • Contact:
          • Phone Number: 463-271-3050
    • Louisiana
      • Metairie, Louisiana, United States, 70006
        • Recruiting
        • Clinical Trials Management, LLC d/b/a Flourish Research
        • Contact:
          • Phone Number: 504-455-1310
        • Principal Investigator:
          • David Dulitz
      • Monroe, Louisiana, United States, 71201
        • Recruiting
        • IMA Clinical Research Monroe - Armand
        • Principal Investigator:
          • Clinton Guillory
    • Maryland
      • Columbia, Maryland, United States, 21045
        • Recruiting
        • Centennial Medical Group
        • Contact:
          • Phone Number: 410-730-3399
        • Principal Investigator:
          • Rajiv Dua
    • Massachusetts
      • New Bedford, Massachusetts, United States, 02740
        • Recruiting
        • Lucida Clinical Trials
        • Principal Investigator:
          • David Shih
        • Contact:
          • Phone Number: 508-720-2015
    • Missouri
      • Chesterfield, Missouri, United States, 63005
        • Recruiting
        • Clinical Research Professionals
        • Contact:
          • Phone Number: 636-220-1200
        • Principal Investigator:
          • Timothy Jennings
      • Springfield, Missouri, United States, 65807
        • Recruiting
        • Clinvest Headlands Llc
        • Contact:
          • Phone Number: 417-883-7889
        • Principal Investigator:
          • Cory Bethmann
    • New Jersey
      • Eatontown, New Jersey, United States, 07724
        • Recruiting
        • Hypertension & Nephrology Association
        • Principal Investigator:
          • spiros Arbes
      • Warren Township, New Jersey, United States, 07059
        • Recruiting
        • IMA Clinical Research Warren
        • Principal Investigator:
          • Nancy Phillips
    • New Mexico
      • Albuquerque, New Mexico, United States, 87102
        • Recruiting
        • Albuquerque Clinical Trials, Inc.
        • Contact:
          • Phone Number: 505-224-7407
        • Principal Investigator:
          • Satkirin Khalsa
    • New York
      • Long Island City, New York, United States, 11106
        • Recruiting
        • NYC Research INC
        • Principal Investigator:
          • Anastasios Manessis
        • Contact:
          • Phone Number: 516-574-9232
    • North Carolina
      • Greensboro, North Carolina, United States, 27408
        • Recruiting
        • PharmQuest Life Sciences, LLC
        • Principal Investigator:
          • Alexander Murray
        • Contact:
          • Phone Number: 336-574-8020
      • Morehead City, North Carolina, United States, 28557
        • Recruiting
        • West Clinical Research
        • Principal Investigator:
          • Patrick Morgante
        • Contact:
          • Phone Number: 252-515-0050
      • Wilmington, North Carolina, United States, 28403
        • Recruiting
        • Trial Management Associates - Wilmington - Floral Parkway
        • Principal Investigator:
          • William Jones
    • North Dakota
      • Fargo, North Dakota, United States, 58104
        • Recruiting
        • Lillestol Research
        • Principal Investigator:
          • Michael Lillestol
        • Contact:
          • Phone Number: 701-232-7705
    • Ohio
      • Lima, Ohio, United States, 45805
        • Recruiting
        • Care Access - Lima
        • Principal Investigator:
          • Jimmy Alele
    • Oregon
      • Portland, Oregon, United States, 97210
        • Recruiting
        • Summit Headlands
        • Principal Investigator:
          • Andre Barkhuizen
    • Pennsylvania
      • Pittsburgh, Pennsylvania, United States, 15243
        • Recruiting
        • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
        • Contact:
          • Phone Number: 412-942-0023
        • Principal Investigator:
          • Daniel Austin
      • Uniontown, Pennsylvania, United States, 15401
        • Recruiting
        • Preferred Primary Care Physicians
        • Contact:
          • Phone Number: 724-438-1479
        • Principal Investigator:
          • Richard Cook II
    • South Carolina
      • Mt. Pleasant, South Carolina, United States, 29464
        • Recruiting
        • Accellacare - Mt Pleasant
        • Contact:
          • Phone Number: 843-849-1880
        • Principal Investigator:
          • Richard Mills
    • Texas
      • Austin, Texas, United States, 78745
        • Recruiting
        • IMA Clinical Research Austin
        • Principal Investigator:
          • Yu-Mei Liu
      • Corpus Christi, Texas, United States, 78414
        • Recruiting
        • Private Practice - Dr. Osvaldo A. Brusco
        • Contact:
          • Phone Number: 361-885-0448
        • Principal Investigator:
          • Osvaldo Brusco
      • Dallas, Texas, United States, 75230
        • Recruiting
        • Velocity Clinical Research, Dallas
        • Principal Investigator:
          • Dan Lender
      • Fort Worth, Texas, United States, 76132
        • Recruiting
        • Diabetes and Thyroid Center of Ft. Worth
        • Contact:
          • Phone Number: 817-263-0007
        • Principal Investigator:
          • Anjanette Tan
      • Houston, Texas, United States, 77040
        • Recruiting
        • Juno Research
        • Contact:
          • Phone Number: 713-779-5494
        • Principal Investigator:
          • Damaris Vega
      • Mesquite, Texas, United States, 75149
        • Recruiting
        • Southern Endocrinology Associates
        • Contact:
          • Phone Number: 214-693-0904
        • Principal Investigator:
          • Sumana Gangi
      • Plano, Texas, United States, 75093
        • Recruiting
        • Research Your Health
        • Principal Investigator:
          • Michele Reynolds
        • Contact:
          • Phone Number: 9729991155 x103
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • IMA Clinical Research San Antonio
        • Contact:
          • Phone Number: 210-692-7157
        • Principal Investigator:
          • Priscilla Thomas
    • Utah
      • Ogden, Utah, United States, 84404
        • Recruiting
        • Ogden Clinic - Canyon View
        • Contact:
          • Phone Number: 385-271-0684
        • Principal Investigator:
          • Stephen Bruce
      • Sandy City, Utah, United States, 84093
        • Recruiting
        • Diabetes & Endocrine Treatment Specialists
        • Principal Investigator:
          • Timothy Graham
        • Contact:
          • Phone Number: 801-816-1010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have type 2 diabetes
  • Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
  • Have a BMI ≥ 27 kg/m2
  • Have a stable body weight (<5% body weight change) for 90 days prior to screening

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes

  • Have taken any of the following antihyperglycemic medications within 90 days before screening:

    • amylin analogs
    • glucagon-like peptide-1 (GLP-1) receptor agonists
    • glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
    • insulin

  • Have had within 90 days prior to screening:

    • heart attack
    • stroke
    • coronary artery revascularization
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Participants will receive placebo SC
Drug: Placebo
Administered SC
Experimental: Eloralintide Dose 1
Participants will receive eloralintide subcutaneously (SC)
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 2
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 3
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 4
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percent Change from Baseline in Body Weight
Time Frame: Baseline, Week 64
Baseline, Week 64

Secondary Outcome Measures

Outcome Measure
Time Frame
Percent Change from Baseline in Total Body Fat Mass
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Waist Circumference
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Hemoglobin A1c (HbA1c)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change in Baseline in Triglycerides
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Body Mass Index (BMI)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in High Sensitivity C-Reactive Protein (hsCRP)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in Fasting Insulin
Time Frame: Baseline, Week 64
Baseline, Week 64
Change in Medication Use
Time Frame: Baseline through Week 64
Baseline through Week 64
Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Short Form-36 (SF-36 v2) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in EQ-5D-5L Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Control of Eating Questionnaire (CoEQ) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight
Time Frame: Baseline, Week 64
Baseline, Week 64
Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)
Time Frame: Baseline through Week 64
Baseline through Week 64
PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)
Time Frame: Baseline through Week 64
Baseline through Week 64

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 15, 2025

Primary Completion (Estimated)

January 1, 2028

Study Completion (Estimated)

February 1, 2028

Study Registration Dates

First Submitted

December 5, 2025

First Submitted That Met QC Criteria

December 5, 2025

First Posted (Actual)

December 15, 2025

Study Record Updates

Last Update Posted (Actual)

August 21, 2026

Last Update Submitted That Met QC Criteria

August 20, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27741
  • 2025 (U.S. NIH Grant/Contract: Faculty of Social Sciences Scientific Grant at the University of Gdańsk)
  • J3R-MC-YDAF (Other Identifier: Eli Lilly and Company)
  • 2025-523658-15-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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