A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin (ENLIGHTEN-6)

May 20, 2026 updated by: Eli Lilly and Company

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy.

Participation in the study will last about 80 weeks.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

900

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 317-615-4559
  • Email: LillyTrials@Lilly.com

Study Locations

  • Australia
      • Botany, Australia, 2019
        • Not yet recruiting
        • Emeritus Research
        • Principal Investigator:
          • Paul Bird
      • Box Hill, Australia, 3128
        • Not yet recruiting
        • Box Hill Hospital
        • Principal Investigator:
          • Ming Li Yee
      • Brisbane, Australia, 4029
        • Not yet recruiting
        • Royal Brisbane and Women's Hospital
        • Principal Investigator:
          • Donald McLeod
        • Contact:
          • Phone Number: +61736468111
      • Camberwell, Australia, 3124
        • Not yet recruiting
        • Emeritus Research
        • Principal Investigator:
          • Sam Francis
      • Geelong, Australia, 3220
        • Not yet recruiting
        • Barwon Health
        • Principal Investigator:
          • Kay Hau (Aaron) Choy
      • Heidelberg West, Australia, 3081
        • Not yet recruiting
        • Austin Health - Repatriation Hospital
        • Contact:
          • Phone Number: 0394962160
        • Principal Investigator:
          • Elif Ekinci
      • Merewether, Australia, 2291
        • Not yet recruiting
        • Aim Research
        • Principal Investigator:
          • Claire Morbey
        • Contact:
          • Phone Number: +61 2 4963 2323
      • Oaklands Park, Australia, 5046
        • Not yet recruiting
        • Southern Adelaide Diabetes & Endocrine Services
        • Principal Investigator:
          • Jui Ho
        • Contact:
          • Phone Number: 0874258693
      • St Leonards, Australia, 2065
        • Not yet recruiting
        • Royal North Shore Hospital
        • Principal Investigator:
          • Sarah Glastras
      • Waitara, Australia, 2077
        • Not yet recruiting
        • Innovate Clinical Research
        • Principal Investigator:
          • Rachel Graham
  • Belgium
      • Bonheiden, Belgium, 2820
        • Not yet recruiting
        • Imelda General Hospital
        • Contact:
          • Phone Number: 003215505164
        • Principal Investigator:
          • Chris Vercammen
      • Brussels, Belgium, 1070
        • Not yet recruiting
        • Université Libre de Bruxelles - Hôpital Erasme
        • Principal Investigator:
          • Laurent Crenier
      • Genk, Belgium, 3600
        • Not yet recruiting
        • Ziekenhuis Oost-Limburg, Campus St.-Jan
        • Principal Investigator:
          • David Verhaert
        • Contact:
          • Phone Number: 3289807250
      • Ieper, Belgium, 8900
        • Not yet recruiting
        • Jan Yperman Ziekenhuis
        • Contact:
          • Phone Number: +3257357270
        • Principal Investigator:
          • An Nollet
      • Kortrijk, Belgium, 8500
        • Not yet recruiting
        • AZ Groeninge Campus Kennedylaan
        • Principal Investigator:
          • Gerd Vanhaverbeke
        • Contact:
          • Phone Number: 003256633180
      • Leuven, Belgium, 3000
        • Not yet recruiting
        • UZ Leuven
        • Contact:
          • Phone Number: 3216346994
        • Principal Investigator:
          • Roman Vangoitsenhoven
      • Mechelen, Belgium, 2800
        • Not yet recruiting
        • AZ Sint-Maarten
        • Contact:
          • Phone Number: +3215892042
        • Principal Investigator:
          • Michel Vandenbroucke
      • Mechelen, Belgium, 2800
        • Not yet recruiting
        • Meclinas
        • Contact:
          • Phone Number: 003215792797
        • Principal Investigator:
          • Julie Casaer
      • Ostend, Belgium, 8400
        • Not yet recruiting
        • Az Damiaan vzw
        • Contact:
          • Phone Number: 059414160
        • Principal Investigator:
          • Marianne Kerrebrouck
  • Brazil
      • Curitiba, Brazil, 80045170
        • Not yet recruiting
        • Quanta Diagnóstico e Terapia
        • Contact:
          • Phone Number: 5541999736442
        • Principal Investigator:
          • Rosangela Rea
      • Curitiba, Brazil, 80810-040
        • Not yet recruiting
        • Centro de Diabetes Curitiba
        • Contact:
          • Phone Number: 554130231252
        • Principal Investigator:
          • LUCIANA PECHMANN
      • Fortaleza, Brazil, 60430-350
        • Not yet recruiting
        • Private Practice - Dr.Miguel N. Hissa
        • Principal Investigator:
          • Miguel Hissa
        • Contact:
          • Phone Number: 55 85 3214.6530
      • São Paulo, Brazil, 01228-200
        • Not yet recruiting
        • CPCLIN
        • Principal Investigator:
          • Denise Franco
        • Contact:
          • Phone Number: 551126303777
      • São Paulo, Brazil, 01409-901
        • Not yet recruiting
        • Hospital 9 De Julho
        • Contact:
          • Phone Number: 551131479432
        • Principal Investigator:
          • Layana Sandes Fraga
      • Vitória, Brazil, 29055450
        • Not yet recruiting
        • CEDOES
        • Contact:
          • Phone Number: 55 27 99933-3330
        • Principal Investigator:
          • Queulla Santos
      • Votuporanga, Brazil, 15500-269
        • Not yet recruiting
        • Integral Pesquisa e Ensino
        • Principal Investigator:
          • GRACIELLY PANTANO
        • Contact:
          • Phone Number: 55017997472217
  • China
      • Beijing, China, 100000
        • Not yet recruiting
        • Luhe Hospital
        • Principal Investigator:
          • Dong Zhao
      • Changchun, China, 130021
        • Not yet recruiting
        • The First Hospital of Jilin University
        • Contact:
          • Phone Number: 15843081103
        • Principal Investigator:
          • Guixia Wang
      • Changchun, China, 130041
        • Not yet recruiting
        • The Second Hospital of Jilin University
        • Principal Investigator:
          • Hanqing Cai
      • Changsha, China, 410011
        • Not yet recruiting
        • The Second Xiangya Hospital of Central South University
        • Principal Investigator:
          • Xia Li
      • Chengdu, China, 610041
        • Not yet recruiting
        • West China Hospital Sichuan University
        • Contact:
          • Phone Number: 18980601658
        • Principal Investigator:
          • zhenmei an
      • Chengdu, China, 610072
        • Not yet recruiting
        • Sichuan Provincial People's Hospital
        • Principal Investigator:
          • Limin Tian
      • Chongqing, China, 400000
        • Not yet recruiting
        • 2nd Affiliated Hospital Chongqing Medical Universi
        • Principal Investigator:
          • Dongfang Liu
        • Contact:
          • Phone Number: 13594028475
      • Guangzhou, China, 510280
        • Not yet recruiting
        • Zhujiang Hospital
        • Principal Investigator:
          • Jia Sun
      • Guiyang, China, 550004
        • Not yet recruiting
        • The Affiliated Hospital of Guizhou Medical University
        • Principal Investigator:
          • Miao Zhang
      • Hefei, China, 230011
        • Not yet recruiting
        • The Second People's hospital of Hefei
        • Principal Investigator:
          • Jun Ye
        • Contact:
          • Phone Number: 86-13956099720
      • Huzhou, China, 313000
        • Not yet recruiting
        • Huzhou Central Hospital
        • Principal Investigator:
          • Shunbin Li
      • Luoyang Shi, China, 471023
        • Not yet recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Principal Investigator:
          • Hongwei Jiang
        • Contact:
          • Phone Number: 13653880139
      • Luzhou, China, 646000
        • Not yet recruiting
        • Affiliated Hospital of Luzhou Medical College
        • Principal Investigator:
          • Qin Wan
      • Nanchang, China, 330006
        • Not yet recruiting
        • Jiangxi Provincial People's Hospital
        • Principal Investigator:
          • Zongyou Cheng
        • Contact:
          • Phone Number: 13767035719
      • Nanjing, China, 210009
        • Not yet recruiting
        • Zhongda Hospital Southeast University
        • Principal Investigator:
          • Ling Li
      • Nanjing, China, 210006
        • Not yet recruiting
        • Nanjing First Hospital
        • Principal Investigator:
          • Jianhua Ma
        • Contact:
          • Phone Number: 18951670116
      • Nanjing, China, 210011
        • Not yet recruiting
        • The Second Affiliated Hospital of Nanjing Medical University
        • Principal Investigator:
          • Yibing Lu
        • Contact:
          • Phone Number: 18951762960
      • Ningbo, China, 315010
        • Not yet recruiting
        • Ningbo First Hospital
        • Contact:
          • Phone Number: 13757426626
        • Principal Investigator:
          • Li Li
      • Shanghai, China, 200032
        • Not yet recruiting
        • Zhongshan Hospital,Fudan University
        • Principal Investigator:
          • Xiaoying Li
        • Contact:
          • Phone Number: 13651913857
      • Wuhan, China, 430014
        • Not yet recruiting
        • The Central Hospital of Wuhan
        • Principal Investigator:
          • Zhongjing Wang
  • Czechia
      • Holešov, Czechia, 769 01
        • Not yet recruiting
        • Diahaza s.r.o.
        • Principal Investigator:
          • Jitka Hasalova Zapletalova
        • Contact:
          • Phone Number: 420573399559
      • Prague, Czechia, 14900
        • Not yet recruiting
        • Milan Kvapil s.r.o., Diabetologicka ambulance
        • Contact:
          • Phone Number: 420272917011
        • Principal Investigator:
          • Frantisek Loos
      • Prague, Czechia, 18100
        • Not yet recruiting
        • ResTrial s.r.o.
        • Contact:
          • Phone Number: 420257211886
        • Principal Investigator:
          • Emilia Malicherova
  • India
      • Allahābād, India, 211002
        • Not yet recruiting
        • Motilal Nehru Medical College Hospital
        • Principal Investigator:
          • JITENDRA SHUKLA
      • Bangalore, India, 560092
        • Not yet recruiting
        • Life Care Hospital and Research Centre
        • Contact:
          • Phone Number: 918023631055
        • Principal Investigator:
          • Sreenivasa Murthy
      • Chennai, India, 600086
        • Not yet recruiting
        • Madras Diabetes Research Foundation
        • Contact:
          • Phone Number: 9840134505
        • Principal Investigator:
          • VISWANATHAN MOHAN
      • Hyderabad, India, 500082
        • Not yet recruiting
        • Nizam's Institute of Medical Sciences
        • Contact:
          • Phone Number: 04023489000
        • Principal Investigator:
          • Beatrice Anne
      • Jaipur, India, 302020
        • Not yet recruiting
        • Eternal Heart Care Center and Research Institute
        • Principal Investigator:
          • Jugal Gupta
      • Kanpur, India, 208011
        • Not yet recruiting
        • Atmaram Child Care
        • Principal Investigator:
          • Manish Singh
      • Kolhāpur, India, 416001
        • Not yet recruiting
        • Shree Mahalaxmi DIATONE Institute
        • Principal Investigator:
          • Rajesh Deshmane
      • Mumbai, India, 400058
        • Not yet recruiting
        • BSES MG Hospital
        • Principal Investigator:
          • MANOJ CHAWLA
        • Contact:
          • Phone Number: 9820002333
      • Mysore, India, 570001
        • Not yet recruiting
        • Mysore Medical College
        • Principal Investigator:
          • Praveen Kumar N S
      • Nagpur, India, 441108
        • Not yet recruiting
        • All India Institute of Medical Sciences (AIIMS) - Nagpur
        • Contact:
          • Phone Number: 9930805548
        • Principal Investigator:
          • Udit Narang
      • Nashik, India, 422002
        • Not yet recruiting
        • Supe Heart & Diabetes Hospital and Research Centre
        • Principal Investigator:
          • Pravin Supe
      • Surat, India, 395002
        • Not yet recruiting
        • Nirmal Hospital Pvt Ltd.
        • Contact:
          • Phone Number: 9825144453
        • Principal Investigator:
          • Piyush Desai
  • Israel
      • Afula, Israel, 1834111
        • Not yet recruiting
        • Emek Medical Center
        • Contact:
          • Phone Number: 97246495139
        • Principal Investigator:
          • Lee Goldstein
      • Atlit, Israel, 3032301
        • Not yet recruiting
        • Clalit Health Services - Atlit
        • Principal Investigator:
          • Elie Haddad
        • Contact:
          • Phone Number: 04-9842020
      • Beersheba, Israel, 8410101
        • Not yet recruiting
        • Soroka Medical Center
        • Principal Investigator:
          • Idit Liberty
        • Contact:
          • Phone Number: 972-8-6403896
      • Hadera, Israel, 3810101
        • Not yet recruiting
        • Hillel Yaffe Medical Center
        • Principal Investigator:
          • Irit Hochberg
        • Contact:
          • Phone Number: 04-7744931
      • Haifa, Israel, 3109601
        • Not yet recruiting
        • Rambam Health Care Campus
        • Principal Investigator:
          • Sagit Zolotov
        • Contact:
          • Phone Number: 972-4-7771606
      • Holon, Israel, 5810001
        • Not yet recruiting
        • Edith Wolfson Medical Center
        • Principal Investigator:
          • Orit Twito
        • Contact:
          • Phone Number: 972-35028392
      • Jerusalem, Israel, 9112001
        • Not yet recruiting
        • Hadassah Medical Center
        • Principal Investigator:
          • Genya Aharon Hananel
        • Contact:
          • Phone Number: 97226776927
      • Kfar Saba, Israel, 4428164
        • Not yet recruiting
        • Meir Medical Center
        • Principal Investigator:
          • Victor Vishlitzky
        • Contact:
          • Phone Number: 972-97472559
      • Kiryat Motzkin, Israel, 2642435
        • Not yet recruiting
        • Maccabi health care services - Qiryat Motzkin
        • Contact:
          • Phone Number: +97248781555
        • Principal Investigator:
          • Afif Nakhleh
      • Netanya, Israel, 4244914
        • Not yet recruiting
        • Laniado Hospital
        • Contact:
          • Phone Number: +97298362745
        • Principal Investigator:
          • Orit Barenholz-Goultschin
      • Petah Tikva, Israel, 4941492
        • Not yet recruiting
        • Rabin Medical Center
        • Principal Investigator:
          • Idit Dotan
        • Contact:
          • Phone Number: +97239377183
      • Petah Tikva, Israel, 4937211
        • Not yet recruiting
        • Rabin Medical Center - Hasharon Campus
        • Principal Investigator:
          • Dror Dicker
        • Contact:
          • Phone Number: 972-3-9372429
      • Ramat Gan, Israel, 5262100
        • Not yet recruiting
        • Sheba Medical Center
        • Contact:
          • Phone Number: 97235302021
        • Principal Investigator:
          • Gabriella Segal Lieberman
      • Rehovot, Israel, 7610001
        • Not yet recruiting
        • Kaplan Medical Center
        • Principal Investigator:
          • Viviana Ostrovsky
        • Contact:
          • Phone Number: 9729441895
      • Sakhnin, Israel, 3081000
        • Not yet recruiting
        • Clalit Health Services - Sakhnin Community Clinic
        • Contact:
          • Phone Number: 97246745729
        • Principal Investigator:
          • Mahmud Darawsha
      • Tel Aviv, Israel, 6423906
        • Not yet recruiting
        • Sourasky Medical Center
        • Contact:
          • Phone Number: 97236973415
        • Principal Investigator:
          • Yael Sofer
      • Tel Aviv, Israel, 51549
        • Not yet recruiting
        • Diabetes Medical Center
        • Principal Investigator:
          • Maya Ish Shalom
        • Contact:
          • Phone Number: 97236900333
  • Japan
      • Chūōku, Japan, 103-0002
        • Recruiting
        • The Institute of Medical Science, Asahi Life Foundation
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yukiko Onishi
      • Izumisano, Japan, 598-8577
        • Not yet recruiting
        • Rinku General Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tomoko Otsuki
      • Kawasaki, Japan, 211-8510
        • Not yet recruiting
        • Kanto Rosai Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yoshio Nagai
      • Kisarazu, Japan, 292-8535
        • Not yet recruiting
        • Kimitsu Chuo Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Ryoichi Ishibashi
      • Kure, Japan, 737-0023
        • Not yet recruiting
        • Kure Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Mitsunobu Kubota
      • Kyoto, Japan, 601-1495
        • Not yet recruiting
        • Takeda General Hospital - Kyoto
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • KIminori Hosoda
      • Matsuyama, Japan, 7900034
        • Recruiting
        • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Tetsuji Niiya
      • Osaka, Japan, 553-0003
        • Not yet recruiting
        • Kansai Electric Power Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yoshiyuki Hamamoto
      • Sapporo, Japan, 060-0062
        • Not yet recruiting
        • Manda Memorial Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Masahiko Kato
      • Shimonoseki, Japan, 750-0061
        • Not yet recruiting
        • Shimonoseki Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kaoru Noda
      • Wakayama, Japan, 640-8558
        • Not yet recruiting
        • Japanese Red Cross Society - Wakayama Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shizuka Kaneko
  • Mexico
      • Chihuahua City, Mexico, 31110
        • Not yet recruiting
        • Medical Center Metas
        • Principal Investigator:
          • Luis Nevarez
        • Contact:
          • Phone Number: 52 614 423 5956
      • Guadalajara, Mexico, 44670
        • Not yet recruiting
        • Private Practice - Dr. Arechavaleta Granell Maria del Rosario
        • Principal Investigator:
          • Maria Arechavaleta Granell
        • Contact:
          • Phone Number: 523336165410 400
      • Huixquilucan, Mexico, 52763
        • Not yet recruiting
        • Invecordis S.C.
        • Principal Investigator:
          • Luisa Villanueva-Rodríguez
        • Contact:
          • Phone Number: 52 55 9185 9959
      • Mexicali, Mexico, 21200
        • Not yet recruiting
        • Centro de Investigacion en Artritis y Osteoporosis SC
        • Principal Investigator:
          • Francisco Lopez Maldonado
        • Contact:
          • Phone Number: 686 5534121
      • Monterrey, Mexico, 64020
        • Not yet recruiting
        • CEINV Salud
        • Principal Investigator:
          • Jose Gerardo González González
        • Contact:
          • Phone Number: 52 8141916867
      • Monterrey, Mexico, 64610
        • Not yet recruiting
        • Clínica García Flores SC
        • Contact:
          • Phone Number: 528113578379
        • Principal Investigator:
          • Pedro García Hernández
  • Puerto Rico
      • Bayamón, Puerto Rico, 00959
        • Recruiting
        • Advanced Clinical Research, LLC
        • Contact:
          • Phone Number: 7872696590
        • Principal Investigator:
          • Angel Comulada-Rivera
      • Guaynabo, Puerto Rico, 00968
        • Recruiting
        • Isis Clinical Research Center
        • Contact:
          • Phone Number: 7874045252
        • Principal Investigator:
          • Paola Mansilla-Letelier
  • Romania
      • Brasov, Romania, 500283
        • Not yet recruiting
        • C.M.D.T.A. Neomed
        • Contact:
          • Phone Number: 0040762249010
        • Principal Investigator:
          • Liliana Marin
      • Brasov, Romania, 500097
        • Not yet recruiting
        • Mariodiab Clinic
        • Principal Investigator:
          • Brindusa Cofaru
        • Contact:
          • Phone Number: 40721203324
      • Bucharest, Romania, 013764
        • Not yet recruiting
        • Centrul Medical NutriLife
        • Principal Investigator:
          • Marlena Pascu
        • Contact:
          • Phone Number: 0040212323445
      • Bucharest, Romania, 010627
        • Not yet recruiting
        • Geea Medical Easy Diet
        • Principal Investigator:
          • Georgeta Vacaru
        • Contact:
          • Phone Number: 40314288633
      • Mangalia, Romania, 905500
        • Not yet recruiting
        • Gama Diamed
        • Contact:
          • Phone Number: 0040241740581
        • Principal Investigator:
          • Amalia Thury-Burileanu
      • Oradea, Romania, 410147
        • Not yet recruiting
        • Diabdana
        • Principal Investigator:
          • Dana Cosma
        • Contact:
          • Phone Number: 004 0722 480 224
      • Satu Mare, Romania, 440055
        • Not yet recruiting
        • Clinica Korall
        • Principal Investigator:
          • Adriana Filimon
        • Contact:
          • Phone Number: 40746013882
      • Targoviste, Romania, 130168
        • Not yet recruiting
        • Rinart Diab SRL
        • Principal Investigator:
          • Anca Nicoara
        • Contact:
          • Phone Number: 0040724372432
      • Timișoara, Romania, 300288
        • Not yet recruiting
        • Cabinet Medical Dr.Geru
        • Contact:
          • Phone Number: 0723377127
        • Principal Investigator:
          • Polina Geru
      • Târgu Mureş, Romania, 540098
        • Not yet recruiting
        • SC Dentosim Queen SRL - Centrul Medical Diamed
        • Principal Investigator:
          • Daniela Ciomos
        • Contact:
          • Phone Number: 0040745641194
  • Spain
      • A Coruña, Spain, 15006
        • Recruiting
        • Hospital San Rafael - La Coruña
        • Contact:
          • Phone Number: 655624017
        • Principal Investigator:
          • Alfonso Soto Gonzalez
      • Almería, Spain, 04009
        • Recruiting
        • Centro Periférico de Especialidades Bola Azul
        • Contact:
          • Phone Number: 0034678510067
        • Principal Investigator:
          • Pedro Mezquita-Raya
      • Barcelona, Spain, 08035
        • Not yet recruiting
        • Hospital Universitari Vall d'Hebron
        • Contact:
          • Phone Number: 34697817352
        • Principal Investigator:
          • ANDREEA CIUDIN
      • Ferrol, Spain, 15402
        • Recruiting
        • Instituto Gallego de Cirugía Ocular
        • Principal Investigator:
          • Alma Maria Prieto tenreiro
      • Palma de Mallorca, Spain, 07014
        • Recruiting
        • Clínica Juaneda
        • Principal Investigator:
          • Santiago Tofe Povedano
        • Contact:
          • Phone Number: 34 871 205256
      • Pozuelo de Alarcón, Spain, 28223
        • Recruiting
        • Hospital Universitario Quironsalud Madrid
        • Principal Investigator:
          • Esteban Jodar Gimeno
        • Contact:
          • Phone Number: 34914522000
      • Santander, Spain, 39008
        • Recruiting
        • Hospital Universitario Marques de Valdecilla
        • Contact:
          • Phone Number: 34639659866
        • Principal Investigator:
          • Luis Vazquez Salvi
      • Seville, Spain, 41010
        • Not yet recruiting
        • Hospital Quiron Infanta Luisa
        • Contact:
          • Phone Number: 670502836
        • Principal Investigator:
          • MARGARITA RIVAS FERNANDEZ
      • Seville, Spain, 41003
        • Recruiting
        • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
        • Principal Investigator:
          • Alberto Aliaga Verdugo
        • Contact:
          • Phone Number: + 34 954709183
      • Seville, Spain, 41950
        • Recruiting
        • Vithas Hospital Sevilla
        • Contact:
          • Phone Number: 658011529
        • Principal Investigator:
          • Cristobal Morales Portillo
  • Taiwan
      • Chiayi City, Taiwan, 600
        • Not yet recruiting
        • Chiayi Christian Hospital
        • Principal Investigator:
          • Chu-Kuang Chou
        • Contact:
          • Phone Number: 886-5-2765041
      • Kaohsiung City, Taiwan, 807
        • Not yet recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Tsung-Hsien Lin
        • Contact:
          • Phone Number: 886-7-3121101 ext 7741
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Not yet recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Principal Investigator:
          • Jung-Fu Chen
        • Contact:
          • Phone Number: +886912159389
      • Taichung, Taiwan, 404332
        • Not yet recruiting
        • China Medical University Hospital
        • Contact:
          • Phone Number: 886923832500
        • Principal Investigator:
          • Wen-Yuan Lin
      • Tainan, Taiwan, 704
        • Not yet recruiting
        • National Cheng Kung University Hospital
        • Principal Investigator:
          • Yi-Ching Yang
        • Contact:
          • Phone Number: 886 62353535 ext 3985
      • Taipei, Taiwan, 11217
        • Not yet recruiting
        • Taipei Veterans General Hospital
        • Contact:
          • Phone Number: 886228757516
        • Principal Investigator:
          • Chii-Min Hwu
      • Taipei, Taiwan, 10002
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chih-Yuan Wang
        • Contact:
          • Phone Number: 0223123456
      • Taipei, Taiwan, 110
        • Not yet recruiting
        • Taipei Medical University Hospital
        • Principal Investigator:
          • Chun-Yao Huang
        • Contact:
          • Phone Number: 886-2-2737-2181 ext 8481
      • Taoyuan, Taiwan, 333
        • Not yet recruiting
        • Chang Gung Medical Foundation-Linkou Branch
        • Principal Investigator:
          • Chia-Hung Lin
  • United States
    • Alabama
      • Birmingham, Alabama, United States, 35209
        • Recruiting
        • Birmingham Clinical Research
        • Principal Investigator:
          • Nova Law
        • Contact:
          • Phone Number: 205-870-4343
    • Arizona
      • Phoenix, Arizona, United States, 85016
        • Recruiting
        • RIO Clinical Trials - Phoenix
        • Principal Investigator:
          • Kenneth Steil
        • Contact:
          • Phone Number: 480-966-7882
      • Scottsdale, Arizona, United States, 85260
        • Recruiting
        • Headlands Research - Scottsdale
        • Contact:
          • Phone Number: 480-725-8708
        • Principal Investigator:
          • Benjamin Clark
      • Tucson, Arizona, United States, 85741
        • Recruiting
        • Novak Clinical Research - Tucson - North La Cholla Boulevard
        • Principal Investigator:
          • Thili Kulatilake
    • California
      • Irvine, California, United States, 92614
        • Recruiting
        • Irvine Clinical Research
        • Contact:
          • Phone Number: 949-753-1663
        • Principal Investigator:
          • Elly Lee
      • La Jolla, California, United States, 92037
        • Recruiting
        • Scripps Whittier Diabetes Institute
        • Contact:
          • Phone Number: 858-824-5352
        • Principal Investigator:
          • Athena Philis-Tsimikas
      • Rolling Hills Estates, California, United States, 90274
        • Recruiting
        • Peninsula Research Associates
        • Contact:
          • Phone Number: 310-265-1623
        • Principal Investigator:
          • Lawrence Sher
      • Sacramento, California, United States, 95831
        • Recruiting
        • Care Access - Sacramento
        • Principal Investigator:
          • Francisco Garcia
        • Contact:
          • Phone Number: 925-734-2331
      • San Diego, California, United States, 92123
        • Recruiting
        • Artemis Institute for Clinical Research
        • Contact:
          • Phone Number: 858-278-3647
        • Principal Investigator:
          • Stacey Layle
      • Santa Ana, California, United States, 92701
        • Recruiting
        • Southern California Clinical Research
        • Contact:
          • Phone Number: 714-474-2173
        • Principal Investigator:
          • Wayne Ho
      • Tustin, California, United States, 92780
        • Recruiting
        • University Clinical Investigators, Inc.
        • Contact:
          • Phone Number: 714-734-7944
        • Principal Investigator:
          • Joanna Van
    • Connecticut
      • Bridgeport, Connecticut, United States, 06606
        • Recruiting
        • New England Research Associates, LLC
        • Contact:
          • Phone Number: 203-374-9816
        • Principal Investigator:
          • Ilja Hulinsky
      • New Haven, Connecticut, United States, 06519
        • Recruiting
        • Yale University School of Medicine
        • Contact:
          • Phone Number: 203-785-7421
        • Principal Investigator:
          • Ania Jastreboff
      • Waterbury, Connecticut, United States, 06708
        • Recruiting
        • Chase Medical Research, LLC
        • Contact:
          • Phone Number: 203-419-4420
        • Principal Investigator:
          • Joseph Soufer
    • Florida
      • Atlantis, Florida, United States, 33462
        • Recruiting
        • JEM Research Institute
        • Principal Investigator:
          • David Halpert
        • Contact:
          • Phone Number: 561-968-2933
      • Doral, Florida, United States, 33172
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Abid Chaudhry
      • Fleming Island, Florida, United States, 32003
        • Recruiting
        • Northeast Research Institute (NERI)
        • Contact:
          • Phone Number: 904-541-8225
        • Principal Investigator:
          • Senan Sultan
      • Jacksonville, Florida, United States, 32216
        • Recruiting
        • Jacksonville Center for Clinical Research
        • Contact:
          • Phone Number: 904-730-0101
        • Principal Investigator:
          • Alpa Patel
      • Miami, Florida, United States, 33165
        • Recruiting
        • New Horizon Research Center
        • Principal Investigator:
          • Lazaro Nunez
        • Contact:
          • Phone Number: 305-226-3933
      • Saint Augustine, Florida, United States, 32086
        • Recruiting
        • St Johns Center for Clinical Research
        • Principal Investigator:
          • Ameeth Vedre
        • Contact:
          • Phone Number: 904-209-0043
      • West Palm Beach, Florida, United States, 33401
        • Recruiting
        • Metabolic Research Institute, Inc.
        • Principal Investigator:
          • Barry Horowitz, MD
        • Contact:
          • Phone Number: 561-802-3060
    • Georgia
      • Dunwoody, Georgia, United States, 30338
        • Recruiting
        • Teak Research Consults - Dunwoody
        • Contact:
          • Phone Number: 470-403-4755
        • Principal Investigator:
          • Aakar Thaker
      • Gainesville, Georgia, United States, 30501
        • Recruiting
        • Center for Advanced Research & Education
        • Principal Investigator:
          • Angela Ritter
        • Contact:
          • Phone Number: 770-534-5154
    • Idaho
      • Idaho Falls, Idaho, United States, 83404
        • Recruiting
        • Family First Medical Center
        • Contact:
          • Phone Number: 208-552-7700
        • Principal Investigator:
          • Flint Packer
    • Illinois
      • Chicago, Illinois, United States, 60640
        • Recruiting
        • Great Lakes Clinical Trials - Ravenswood
        • Principal Investigator:
          • Rupal Trivedi
        • Contact:
          • Phone Number: 773-275-3500 Ext 126
    • Iowa
      • West Des Moines, Iowa, United States, 50266
        • Recruiting
        • Iowa Diabetes and Endocrinology Research Center
        • Contact:
          • Phone Number: 515-329-6800
        • Principal Investigator:
          • Robert Burr
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Recruiting
        • Cotton O'Neil Diabetes & Endocrinology
        • Principal Investigator:
          • susan brian
        • Contact:
          • Phone Number: 785-354-9591
    • Kentucky
      • Lexington, Kentucky, United States, 40509
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Mark Adams
        • Contact:
          • Phone Number: 859-264-8999
    • Louisiana
      • Monroe, Louisiana, United States, 71201
        • Recruiting
        • IMA Clinical Research Monroe - Armand
        • Principal Investigator:
          • Clinton Guillory
    • Maryland
      • Columbia, Maryland, United States, 21045
        • Recruiting
        • Centennial Medical Group
        • Contact:
          • Phone Number: 410-730-3399
        • Principal Investigator:
          • Rajiv Dua
    • Massachusetts
      • Boston, Massachusetts, United States, 02115
        • Not yet recruiting
        • Brigham and Women's Hospital Diabetes Program
        • Principal Investigator:
          • Vanita Aroda
        • Contact:
          • Phone Number: 617-732-4245
      • Waltham, Massachusetts, United States, 02451
        • Not yet recruiting
        • MedVadis Research Corporation
        • Contact:
          • Phone Number: 617-744-1310
        • Principal Investigator:
          • David DiBenedetto
    • Michigan
      • Southfield, Michigan, United States, 48075
        • Recruiting
        • Great Lakes Research Institute
        • Principal Investigator:
          • Derrick Williamson
        • Contact:
          • Phone Number: 248-864-5242
      • Troy, Michigan, United States, 48098
        • Recruiting
        • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
        • Contact:
          • Phone Number: 248-312-0025
        • Principal Investigator:
          • Neil Fraser
    • Missouri
      • Chesterfield, Missouri, United States, 63005
        • Recruiting
        • Clinical Research Professionals
        • Contact:
          • Phone Number: 636-220-1200
        • Principal Investigator:
          • Timothy Jennings
    • New York
      • New York, New York, United States, 10016
        • Recruiting
        • NYU Langone Health
        • Contact:
          • Phone Number: 212-263-3166
        • Principal Investigator:
          • Holly Lofton
      • New York, New York, United States, 10021
        • Recruiting
        • Weill Cornell Medical College
        • Contact:
          • Phone Number: 646-962-2111
        • Principal Investigator:
          • Louis Aronne
      • New York, New York, United States, 10036
        • Recruiting
        • Ima Clinical Research Manhattan
        • Principal Investigator:
          • Eli Shalenberg
    • North Carolina
      • Chapel Hill, North Carolina, United States, 27514
        • Recruiting
        • University of North Carolina Medical Center
        • Contact:
          • Phone Number: 984-974-3004
        • Principal Investigator:
          • Klara Klein
      • Greensboro, North Carolina, United States, 27405
        • Recruiting
        • Medication Management
        • Contact:
          • Phone Number: 336-763-6968
        • Principal Investigator:
          • James Franklin
      • Morehead City, North Carolina, United States, 28557
        • Recruiting
        • Carteret Medical Group
        • Contact:
          • Phone Number: 252-499-8623
        • Principal Investigator:
          • Mary Lawrence
      • Wilmington, North Carolina, United States, 28401
        • Recruiting
        • Accellacare - Wilmington - 1917 Tradd Court
        • Principal Investigator:
          • John Parker
        • Contact:
          • Phone Number: 910-799-5500
    • Ohio
      • Lima, Ohio, United States, 45805
        • Recruiting
        • Care Access - Lima
        • Principal Investigator:
          • Jimmy Alele
    • Pennsylvania
      • Pittsburgh, Pennsylvania, United States, 15236
        • Recruiting
        • Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)
        • Contact:
          • Phone Number: 412-650-6155
        • Principal Investigator:
          • Bryce Palchick
    • Texas
      • Dallas, Texas, United States, 75390
        • Recruiting
        • UT Southwestern Medical Center
        • Principal Investigator:
          • Amy Shah
      • Houston, Texas, United States, 77040
        • Recruiting
        • Juno Research
        • Contact:
          • Phone Number: 713-779-5494
        • Principal Investigator:
          • Damaris Vega
      • Missouri City, Texas, United States, 77459
        • Recruiting
        • Synergy Groups Medical LLC - Missouri City
        • Principal Investigator:
          • Deirdre McMullen
        • Contact:
          • Phone Number: 832-532-4210
      • San Antonio, Texas, United States, 78240
        • Recruiting
        • Endeavor Clinical Trials
        • Principal Investigator:
          • Nitendra Agarwal
        • Contact:
          • Phone Number: 518-428-6859
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • IMA Clinical Research San Antonio
        • Contact:
          • Phone Number: 210-692-7157
        • Principal Investigator:
          • Priscilla Thomas
      • Shavano Park, Texas, United States, 78231
        • Recruiting
        • Consano Clinical Research, LLC
        • Contact:
          • Phone Number: 210-545-4900
        • Principal Investigator:
          • Michelle Welch
      • Weslaco, Texas, United States, 78596
        • Recruiting
        • Texas Valley Clinical Research
        • Principal Investigator:
          • Eduardo Luna
        • Contact:
          • Phone Number: 956-431-8090
      • Wylie, Texas, United States, 75098
        • Recruiting
        • Medrasa Clinical Research
        • Contact:
          • Phone Number: 469-449-3645
        • Principal Investigator:
          • Tanvir Ahmad

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Are on stable incretin therapy at screening

  • With persistent obesity or overweight defined as:

    • ≥30 kg/m2 OR

    • ≥27 kg/m2 with at least one existing obesity related complication at screening:

      • hypertension
      • dyslipidemia
      • obstructive sleep apnea
      • cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
      • type 2 diabetes
  • Have a stable body weight (<5% body weight change) at screening

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes

  • Have taken any of the following antihyperglycemic medications within 90 days before screening:

    • dipeptidyl peptidase-4 (DPP-4) inhibitors
    • amylin analogs
    • insulin

  • Have had within 90 days prior to screening:

    • heart attack
    • stroke
    • coronary artery revascularization
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo
Participants will receive placebo SC
Drug: Placebo
Administered SC
Experimental: Eloralintide Dose 1
Participants will receive eloralintide subcutaneously (SC)
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 2
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 3
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Experimental: Eloralintide Dose 4
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percent Change from Baseline in Body Weight
Time Frame: Baseline, Week 64
Baseline, Week 64

Secondary Outcome Measures

Outcome Measure
Time Frame
Change from Baseline in Waist Circumference
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change in Baseline in Triglycerides
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Systolic Blood Pressure
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Body Mass Index (BMI)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in High Sensitivity C-Reactive Protein (hsCRP)
Time Frame: Baseline, Week 64
Baseline, Week 64
Percent Change from Baseline in Fasting Insulin
Time Frame: Baseline, Week 64
Baseline, Week 64
Change in Medication Use
Time Frame: Baseline through Week 64
Baseline through Week 64
Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Short Form-36 (SF-36 v2) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in EQ-5D-5L Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Change from Baseline in Control of Eating Questionnaire (CoEQ) Score
Time Frame: Baseline, Week 64
Baseline, Week 64
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight
Time Frame: Baseline, Week 64
Baseline, Week 64
Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)
Time Frame: Baseline through Week 64
Baseline through Week 64
PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)
Time Frame: Baseline through Week 64
Baseline through Week 64
Change from Baseline in Fasting Glucose in Participants with Type 2 Diabetes at Baseline
Time Frame: Baseline, Week 64
Baseline, Week 64

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 10, 2026

Primary Completion (Estimated)

June 1, 2028

Study Completion (Estimated)

July 1, 2028

Study Registration Dates

First Submitted

January 30, 2026

First Submitted That Met QC Criteria

January 30, 2026

First Posted (Actual)

February 6, 2026

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 20, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27743
  • J3R-MC-YDAL (Other Identifier: Eli Lilly and Company)
  • 2025-523659-73-00 (Ctis)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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