LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)

May 20, 2026 updated by: Eli Lilly and Company

A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)

The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally.

The study will last up to approximately 108 weeks, excluding screening.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1431

Phase

  • Phase 2

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 1-317-615-4559
  • Email: LillyTrials@Lilly.com

Study Contact Backup

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1128AAF
        • Not yet recruiting
        • Mautalen Salud e Investigación
        • Principal Investigator:
          • Emiliano Tron
        • Contact:
          • Phone Number: +541145143408
      • Buenos Aires, Argentina, C1023AAB
        • Not yet recruiting
        • Stat Research S.A.
        • Contact:
          • Phone Number: 54111550120614
        • Principal Investigator:
          • Maria Linares
      • Buenos Aires, Argentina, C1425BGC
        • Not yet recruiting
        • GEDYT
        • Contact:
          • Phone Number: 54 11 5288 6107
        • Principal Investigator:
          • Silvina Goncalves
      • Quilmes, Argentina, 1878
        • Not yet recruiting
        • CER medical Institute
        • Principal Investigator:
          • EDGARDO DANIEL GIMENEZ
      • Rosario, Argentina, 2002
        • Not yet recruiting
        • Hospital Provincial del Centenario
        • Contact:
          • Phone Number: 5493415329980
        • Principal Investigator:
          • JOAQUIN MONTERO
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • INECO Neurociencias Oroño
        • Principal Investigator:
          • Sebastian Ferretti
        • Contact:
          • Phone Number: +54 9 3416 18-5727
      • San Isidro, Argentina, 1642
        • Not yet recruiting
        • Instituto Médico de Alta Complejidad San Isidro Sa
        • Principal Investigator:
          • EDGARDO SMECUOL
      • San Miguel de Tucumán, Argentina, 4000
        • Not yet recruiting
        • C.I.C.E. 9 de Julio
        • Contact:
          • Phone Number: 5493816299018
        • Principal Investigator:
          • Abel Novillo
  • Brazil
      • Campinas, Brazil, 13092-133
        • Not yet recruiting
        • Loema Instituto de Pesquisa Clinica
        • Principal Investigator:
          • Joaquim Simoes Neto
        • Contact:
          • Phone Number: 19 3252-5611
      • Caxias do Sul, Brazil, 95070-560
        • Not yet recruiting
        • Fundação Universidade de Caxias do Sul (FUCS)
        • Principal Investigator:
          • Eduardo Brambilla
      • Curitiba, Brazil
        • Not yet recruiting
        • HNSG
        • Contact:
          • Phone Number: +55 41 99968-0290
        • Principal Investigator:
          • HEDA MARIA AMARANTE
      • Fortaleza, Brazil, 60140-025
        • Not yet recruiting
        • Centro de Oncologia Leonardo Da Vinci - ATO Terapias
        • Principal Investigator:
          • Caio Freire
      • Porto Alegre, Brazil, 90160-092
        • Not yet recruiting
        • Hospital Ernesto Dornelles
        • Principal Investigator:
          • Cristina Flores
        • Contact:
          • Phone Number: +5551999624012
      • Salvador, Brazil, 41920-900
        • Not yet recruiting
        • Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
        • Contact:
          • Phone Number: 55 71 2108-5600
        • Principal Investigator:
          • Raymundo Parana
      • Santos, Brazil, 11075-900
        • Not yet recruiting
        • Irmandade da Santa Casa da Misericórdia de Santos
        • Contact:
          • Phone Number: +5513997113072
        • Principal Investigator:
          • Jose Eduardo Vasconcelos Fernandes
      • São Paulo, Brazil, 04543-011
        • Not yet recruiting
        • Clínica Hepatogastro JK
        • Principal Investigator:
          • Rodrigo Andrey Rocco
        • Contact:
          • Phone Number: 5511999158070
      • São Paulo, Brazil, 01236030
        • Not yet recruiting
        • Br Trials - Ensaios Clínicos e Consultoria
        • Principal Investigator:
          • Roberto da Silva
      • Tajaí, Brazil, 88301-220
        • Not yet recruiting
        • BRA - Clínica Médica e Terapia Assistida
        • Principal Investigator:
          • Munique Kurtz de Mello
  • Canada
      • Greater Sudbury, Canada, P3E 5J1
        • Not yet recruiting
        • Health Sciences North
        • Principal Investigator:
          • Anas Eddin
      • Halifax, Canada, B3H 2Y9
        • Not yet recruiting
        • QEII Health Sciences Centre - Victoria General Site
        • Principal Investigator:
          • Jennifer Jones
      • London, Canada, N6K 1M6
        • Not yet recruiting
        • London Digestive Disease Institute
        • Principal Investigator:
          • Vipul Jairath
  • China
      • Binzhou, China, 256603
        • Not yet recruiting
        • Binzhou Medical University Hospital
        • Principal Investigator:
          • Chengxia Liu
      • Changzhou, China, 213000
        • Not yet recruiting
        • Changzhou Second People's Hospital
        • Principal Investigator:
          • Wenjia LIU
      • Chengdu, China, 610072
        • Not yet recruiting
        • Sichuan Provincial People's Hospital
        • Contact:
          • Phone Number: 18981838298
        • Principal Investigator:
          • Xue Yang
      • Chongqing, China, 401147
        • Not yet recruiting
        • Chongqing General Hospital
        • Principal Investigator:
          • Hong Guo
        • Contact:
          • Phone Number: 86-13508389768
      • Foshan, China, 528041
        • Not yet recruiting
        • The First People's Hospital of Foshan
        • Principal Investigator:
          • Zhaotao Li
      • Guangzhou, China, 510655
        • Not yet recruiting
        • The Sixth Affiliated Hospital of Sun Yat-Sen University
        • Principal Investigator:
          • Xiang Gao
      • Harbin, China, 150036
        • Not yet recruiting
        • Heilongjiang Provincial Hospital
        • Principal Investigator:
          • Xiaomei Sun
      • Hefei, China, 230022
        • Not yet recruiting
        • The First Affiliated Hospital of Anhui Medical University
        • Principal Investigator:
          • Juan Wu
      • Huizhou, China, 516001
        • Not yet recruiting
        • Huizhou Central People's Hospital
        • Principal Investigator:
          • Huixin Chen
      • Kunming, China, 650032
        • Not yet recruiting
        • First Affiliated Hospital of Kunming Medical University
        • Principal Investigator:
          • Jiarong Miao
      • Liaocheng, China, 252000
        • Not yet recruiting
        • Liaocheng People's Hospital
        • Principal Investigator:
          • Cuicui Lang
      • Meihekou, China, 135000
        • Not yet recruiting
        • Meihekou Central Hospital
        • Principal Investigator:
          • Zhongwei Pan
      • Qingdao, China, 266003
        • Not yet recruiting
        • The Affiliated Hospital Of Qingdao University
        • Principal Investigator:
          • Xueli Ding
      • Shanghai, China, 201318
        • Not yet recruiting
        • Shanghai Pudong New District Zhoupu Hospital
        • Principal Investigator:
          • Zhihua Ran
      • Shanghai, China, 200072
        • Not yet recruiting
        • Shanghai Tenth People's Hospital
        • Principal Investigator:
          • Xiaolei Wang
      • Shaoguan, China, 512026
        • Not yet recruiting
        • Yuebei People's Hospital Guangdong
        • Principal Investigator:
          • Manran Zhu
      • Shenzhen, China, 518036
        • Not yet recruiting
        • Peking University Shenzhen Hospital
        • Principal Investigator:
          • Wenke Chen
      • Suzhou, China, 215006
        • Not yet recruiting
        • The First Affiliated Hospital of Soochow University
        • Principal Investigator:
          • Weichang Chen
      • Taian, China, 271000
        • Not yet recruiting
        • Taian City Central Hospital
        • Principal Investigator:
          • Haipeng Yuan
        • Contact:
          • Phone Number: 13375387610
      • Wuhan, China, 430022
        • Not yet recruiting
        • Wuhan Union Hospital
        • Principal Investigator:
          • Xiaohua Hou
      • Wuhan, China, 430060
        • Not yet recruiting
        • Renmin Hospital of Wuhan University
        • Principal Investigator:
          • Ping An
      • Zunyi, China, 563003
        • Not yet recruiting
        • Zunyi Medical College - No.1 Affiliated Hospital
        • Principal Investigator:
          • Murong Liu
  • Colombia
      • Barranquilla, Colombia, 080020
        • Not yet recruiting
        • Clinica de la Costa S.A.S.
        • Principal Investigator:
          • Leonardo Brochado
      • Bogotá, Colombia
        • Not yet recruiting
        • Hospital Universitario San Ignacio
        • Principal Investigator:
          • Ana Leguizamo
      • Bogotá, Colombia, 110111
        • Not yet recruiting
        • Fundacion Santa Fe de Bogota
        • Contact:
          • Phone Number: 3212108418
        • Principal Investigator:
          • GUSTAVO REYES
      • Bogotá, Colombia, 111411
        • Not yet recruiting
        • Hospital Universitario Mayor Méderi
        • Principal Investigator:
          • Carlos Figueroa
      • Medellín, Colombia, 050034
        • Not yet recruiting
        • Hospital Pablo Tobón Uribe
        • Principal Investigator:
          • Jhon Carvajal Gutierrez
  • Croatia
      • Osijek, Croatia, 31000
        • Not yet recruiting
        • Poliklinika Borzan
        • Principal Investigator:
          • Vladimir Borzan
      • Rijeka, Croatia, 51000
        • Not yet recruiting
        • Poliklinika MEDICO - Rijeka
        • Principal Investigator:
          • Boris Brozovic
      • Split, Croatia, 21000
        • Not yet recruiting
        • Klinicki bolnicki centar Split
        • Principal Investigator:
          • Zeljko Puljiz
      • Zagreb, Croatia, 10000
        • Not yet recruiting
        • Poliklinika Solmed
        • Principal Investigator:
          • Dejan Bakula
      • Zagreb, Croatia, 10000
        • Not yet recruiting
        • Klinicki bolnicki centar Zagreb
        • Principal Investigator:
          • Zeljko Krznaric
  • Czechia
      • Hradec Králové, Czechia, 500 12
        • Not yet recruiting
        • Hepato-Gastroenterologie HK
        • Principal Investigator:
          • Miroslava Volfova
      • Pardubice, Czechia, 532 03
        • Not yet recruiting
        • Nemocnice Pardubického kraje
        • Principal Investigator:
          • Petr Vyhnalek
        • Contact:
          • Phone Number: +420466014229
      • Prague, Czechia, 19000
        • Not yet recruiting
        • ISCARE klinické centrum
        • Principal Investigator:
          • Milan Lukas
        • Contact:
          • Phone Number: +420 725 505 279
      • Prague, Czechia, 140 00
        • Not yet recruiting
        • Clinoxus
        • Principal Investigator:
          • Petr Hrabak
      • Prague, Czechia, 140 00
        • Not yet recruiting
        • MEDICON
        • Contact:
          • Phone Number: +420 222 501 720
        • Principal Investigator:
          • David Kamenar
      • Slaný, Czechia, 274 01
        • Not yet recruiting
        • Nemocnice Slany
        • Principal Investigator:
          • Martin Peterka
        • Contact:
          • Phone Number: + 420 606 661 523
      • Sternberk, Czechia, 785 01
        • Not yet recruiting
        • Nemocnice AGEL Šternberk
        • Contact:
          • Phone Number: +420582315464
        • Principal Investigator:
          • Jaroslav Macecek
      • Uherské Hradiště, Czechia, 686 01
        • Not yet recruiting
        • Clinical Trials Service s.r.o.
        • Principal Investigator:
          • Vladimir Cech
      • Vsetín, Czechia, 755 01
        • Not yet recruiting
        • Gastro-nell
        • Contact:
          • Phone Number: +420 775 316 692
        • Principal Investigator:
          • Vladimir Vaculin
  • France
      • Neuilly-sur-Seine, France, 92200
        • Not yet recruiting
        • Centres Médico Chirurgicaux - Clinique Ambroise Paré
        • Principal Investigator:
          • Xavier Treton
        • Contact:
          • Phone Number: 01 41 43 05 73
      • Pessac, France, 33600
        • Not yet recruiting
        • CHU Bordeaux Haut-Leveque
        • Principal Investigator:
          • Pauline RIVIERE
      • Pierre-Bénite, France, 69310
        • Not yet recruiting
        • Centre Hospitalier Lyon Sud
        • Principal Investigator:
          • Gilles BOSCHETTI
      • Toulouse, France, 31059
        • Not yet recruiting
        • CHU Rangueil
        • Principal Investigator:
          • cyrielle Gilletta
  • Greece
      • Athens, Greece, 106 76
        • Not yet recruiting
        • Evangelismos General Hospital of Athens
        • Principal Investigator:
          • NIKOLAOS VIAZIS
      • Athens, Greece, 115 27
        • Not yet recruiting
        • Thoracic General Hospital of Athens "I Sotiria"
        • Principal Investigator:
          • Giorgos Bamias
        • Contact:
          • Phone Number: +306976062713
      • Heraklion, Greece, 711 10
        • Not yet recruiting
        • University General Hospital of Heraklion
        • Principal Investigator:
          • Ioannis Koutroubakis
        • Contact:
          • Phone Number: 2810392037
      • Thessaloniki, Greece, 54642
        • Not yet recruiting
        • Ippokrateio General Hospital of Thessaloniki
        • Principal Investigator:
          • OLGA GIOULEME
  • Hungary
      • Budapest, Hungary, 1036
        • Not yet recruiting
        • Óbudai Egészségügyi Centrum
        • Principal Investigator:
          • Tamás Toth
        • Contact:
          • Phone Number: 06309399575
      • Budapest, Hungary, 1083
        • Not yet recruiting
        • Semmelweis University
        • Principal Investigator:
          • Akos Ilias
      • Gyöngyös, Hungary, 3200
        • Not yet recruiting
        • Clinexpert Gyöngyös
        • Principal Investigator:
          • Gyula Horvat
        • Contact:
          • Phone Number: +36209650290
      • Tatabánya, Hungary, 2800
        • Not yet recruiting
        • Komarom-Esztergom Varmegyei Szent Borbala Korhaz
        • Principal Investigator:
          • András Káfony
        • Contact:
          • Phone Number: 36309578269
  • India
      • Allahābād, India, 211002
        • Not yet recruiting
        • Motilal Nehru Medical College Hospital
        • Principal Investigator:
          • Sandeep Prajapati
      • Belagavi, India, 590010
        • Not yet recruiting
        • KLES Dr. Prabhakar Kore Hospital & M.R.C
        • Principal Investigator:
          • Santosh Hajare
      • Belgavi, India, 590019
        • Not yet recruiting
        • Belagavi Institute of Medical Sciences - Belagavi
        • Principal Investigator:
          • Ganesh Koppad
      • Dehradun, India, 248008
        • Not yet recruiting
        • Graphic Era Institute of Medical Sciences and Hospital
        • Principal Investigator:
          • Sachin Dev Munjal
      • Hyderabad, India, 500004
        • Not yet recruiting
        • Mahavir Hospital & Research Centre - Hyderabad
        • Principal Investigator:
          • Rupender Prasad
      • Jaipur, India, 302001
        • Not yet recruiting
        • SR Kalla Memorial Gastro & General Hospital
        • Principal Investigator:
          • Mukesh Kalla
        • Contact:
          • Phone Number: 0141-4039432
      • Kochi, India, 682040
        • Not yet recruiting
        • Lakeshore Hospital
        • Contact:
          • Phone Number: 04842154754
        • Principal Investigator:
          • Abraham Koshy
      • Lucknow, India, 226010
        • Not yet recruiting
        • Dr. Ram Manohar Lohia Institute of Medical Sciences
        • Principal Investigator:
          • Piyush Upadhyay
      • Mumbai, India, 400008
        • Not yet recruiting
        • Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
        • Principal Investigator:
          • Shubham Jain
      • Nagpur, India, 440010
        • Not yet recruiting
        • Midas Multispeciality Hospital Pvt.Ltd.
        • Principal Investigator:
          • Shrikant Mukewar
      • Nagpur, India, 441108
        • Not yet recruiting
        • All India Institute of Medical Sciences (AIIMS) - Nagpur
        • Contact:
          • Phone Number: 8475000331
        • Principal Investigator:
          • Rutwik Loya
      • New Delhi, India, 110029
        • Not yet recruiting
        • All India Institute of Medical Sciences
        • Principal Investigator:
          • Vineet Ahuja
        • Contact:
          • Phone Number: 09867932836
      • Noida, India, 201306
        • Not yet recruiting
        • Yatharth Super Speciality Hospital - Noida Extension
        • Principal Investigator:
          • Rakesh Kumar Jagdish
      • Pune, India, 411057
        • Not yet recruiting
        • Lifepoint Multispeciality Hospital
        • Principal Investigator:
          • Amol Dahale
      • Pune, India, 411027
        • Not yet recruiting
        • Gastrohub Hospital
        • Principal Investigator:
          • Mahesh Mahadik
      • Udaipur, India, 313001
        • Not yet recruiting
        • Pacific Medical College & Hospital
        • Principal Investigator:
          • Ashish Mehta
  • Israel
      • Ashdod, Israel, 7747629
        • Not yet recruiting
        • Assuta Ashdod Medical Center
        • Principal Investigator:
          • Adi Lahat-Zok
        • Contact:
          • Phone Number: +9720723398277
      • Ashkelon, Israel, 7830604
        • Not yet recruiting
        • Barzilai Medical Center
        • Contact:
          • Phone Number: +97286745244
        • Principal Investigator:
          • Ofer Ben-Bassat
      • Haifa, Israel, 3109601
        • Not yet recruiting
        • Rambam Health Care Campus
        • Contact:
          • Phone Number: 972-4-7772850
        • Principal Investigator:
          • Roni Weisshof
      • Jerusalem, Israel, 9362410
        • Not yet recruiting
        • Clalit Health Services - Lev Talpiot Clinic
        • Principal Investigator:
          • Nadav Ilani
        • Contact:
          • Phone Number: +97225457100
      • Kfar Saba, Israel, 4428164
        • Not yet recruiting
        • Meir Medical Center
        • Principal Investigator:
          • Michal Openhaim
        • Contact:
          • Phone Number: +97297471017
      • Ẕerifin, Israel, 7033001
        • Not yet recruiting
        • Yitzhak Shamir Medical Center
        • Contact:
          • Phone Number: 9728779720
        • Principal Investigator:
          • Leore Mendel
  • Italy
      • Milan, Italy, 20132
        • Not yet recruiting
        • Ospedale San Raffaele
        • Principal Investigator:
          • Silvio Danese
      • Milan, Italy, 20097
        • Not yet recruiting
        • IRCCS Policlinico San Donato
        • Principal Investigator:
          • Vito Annese
        • Contact:
          • Phone Number: 39 0252774951
      • Rho, Italy, 20017
        • Not yet recruiting
        • Ospedale di Circolo
        • Principal Investigator:
          • Simone Saibeni
        • Contact:
          • Phone Number: 02 99430.3264
      • Rome, Italy, 00152
        • Not yet recruiting
        • Azienda Ospedaliera San Camillo Forlanini
        • Principal Investigator:
          • Rita Monterubbianesi
      • Rome, Italy, 00133
        • Not yet recruiting
        • Fondazione Policlinico Tor Vergata
        • Principal Investigator:
          • Irene Marafini
      • Rome, Italy, 00186
        • Not yet recruiting
        • Ospedale Isola Tiberina - Gemelli Isola
        • Contact:
          • Phone Number: +390668370271
        • Principal Investigator:
          • Daniela Pugliese
      • Rozzano, Italy, 20089
        • Not yet recruiting
        • Humanitas
        • Principal Investigator:
          • Alessandro Armuzzi
        • Contact:
          • Phone Number: 0282243263
  • Japan
      • Asahikawa, Japan, 078-8510
        • Not yet recruiting
        • Asahikawa Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Mikihiro Fujiya
      • Bunkyō City, Japan, 113-8431
        • Not yet recruiting
        • Juntendo University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Dai Ishikawa
      • Fujiidera, Japan, 583-0027
        • Not yet recruiting
        • Sai Gastroenterology/Proctology Clinic
        • Principal Investigator:
          • Souken Sai
        • Contact:
          • Phone Number: 81120023812
      • Fukuoka, Japan, 814-0180
        • Not yet recruiting
        • Fukuoka University Hospital
        • Principal Investigator:
          • Fumihito Hirai
        • Contact:
          • Phone Number: 81120023812
      • Hirosaki, Japan, 036-8545
        • Not yet recruiting
        • National Hospital Organization Hirosaki General Medical Center
        • Principal Investigator:
          • Yoh Ishiguro
        • Contact:
          • Phone Number: 81120023812
      • Kagoshima, Japan, 892-0846
        • Not yet recruiting
        • Sameshima Hospital
        • Principal Investigator:
          • nobuaki nishimata
        • Contact:
          • Phone Number: 81120023812
      • Kashiwa, Japan, 273-0011
        • Not yet recruiting
        • Tsujinaka Hospital - Kashiwanoha
        • Principal Investigator:
          • Ken Takeuchi
        • Contact:
          • Phone Number: 81120023812
      • Mitaka, Japan, 181-8611
        • Not yet recruiting
        • Kyorin University Hospital
        • Principal Investigator:
          • TADAKAZU HISAMATSU
        • Contact:
          • Phone Number: 81120023812
      • Niigata, Japan, 950-1104
        • Not yet recruiting
        • Saiseikai Niigata Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Junji Yokoyama
      • Nishinomiya, Japan, 663-8501
        • Not yet recruiting
        • Hyogo Medical University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Shinichiro Shinzaki
      • Okayama, Japan, 700-8558
        • Not yet recruiting
        • Okayama University Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Toshihiro Inokuchi
      • Saitama, Japan, 336-0963
        • Not yet recruiting
        • Tokitokai Tokito Clinic Coloproctology Center
        • Principal Investigator:
          • Satoki Tokito
        • Contact:
          • Phone Number: 81120023812
      • Sapporo, Japan, 065-0033
        • Not yet recruiting
        • Sapporo Higashi Tokushukai Hospital
        • Principal Investigator:
          • Atsuo Maemoto
        • Contact:
          • Phone Number: 81120023812
      • Suita, Japan, 565-0871
        • Not yet recruiting
        • The University of Osaka Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Takeo Yoshihara
      • Tokyo, Japan, 169-0073
        • Not yet recruiting
        • Tokyo Yamate Medical Center
        • Principal Investigator:
          • Masayuki Fukata
        • Contact:
          • Phone Number: 81120023812
  • Latvia
      • Liepāja, Latvia, LV-3414
        • Not yet recruiting
        • Liepjas reionl slimnca
        • Principal Investigator:
          • Linda Erne
        • Contact:
          • Phone Number: 29526821
      • Riga, Latvia, LV-1002
        • Not yet recruiting
        • Pauls Stradins Clinical Univeristy Hospital
        • Principal Investigator:
          • Aldis Pukitis
      • Riga, Latvia, LV-1035
        • Not yet recruiting
        • VCA poliklīnika Aura
        • Principal Investigator:
          • Aleksejs Derovs
  • Lithuania
      • Kaunas, Lithuania, LT-50161
        • Not yet recruiting
        • Hospital of Lithuanian University of Health Sciences Kauno Klinikos
        • Principal Investigator:
          • Gediminas Kiudelis
      • Klaipėda, Lithuania, 92288
        • Not yet recruiting
        • Klaipeda university hospital
        • Principal Investigator:
          • Aiste Puriene
      • Klaipėda, Lithuania, 93200
        • Not yet recruiting
        • Viesoji Istaiga Klaipedos Miesto Poliklinika
        • Principal Investigator:
          • Giedrius Simulionis
        • Contact:
          • Phone Number: +37046345968
  • Mexico
      • Chihuahua City, Mexico, 31207
        • Not yet recruiting
        • Scientia Investigacion Clinica S.C.
        • Principal Investigator:
          • CHRISTIAN NAVARRO GERRARD
      • Ciudad de Tijuana, Mexico, 22105
        • Not yet recruiting
        • Scientia Investigacion Clinica Tj
        • Principal Investigator:
          • Luis Lopez
      • Guadalajara, Mexico, 44650
        • Not yet recruiting
        • Clinica de Investigacion en Reumatologia y Obesidad S. C.
        • Principal Investigator:
          • Hector Martinez Torres
      • Guadalajara, Mexico, 44670
        • Not yet recruiting
        • Private Practice - Dr. Adriana Sánchez
        • Principal Investigator:
          • Aranzazu Perez
      • Irapuato, Mexico, 36520
        • Not yet recruiting
        • PROACTIVE CR MEXICO SA de CV
        • Principal Investigator:
          • Andrés Mendoza Sanchez
      • Mexico City, Mexico, 04100
        • Not yet recruiting
        • Centro de Investigación Clinica Chapultepec
        • Principal Investigator:
          • Elda Rodriguez Negrete
      • Mexico City, Mexico, 14080
        • Not yet recruiting
        • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
        • Principal Investigator:
          • JESUS YAMAMOTO-FURUSHO
      • Mexico City, Mexico, 03330
        • Not yet recruiting
        • Centro de Investigación y Gastroenterología - S.C.
        • Contact:
          • Phone Number: 5510546591
        • Principal Investigator:
          • Alma Ladron de Guevara Cetina
      • Mexico City, Mexico, 07760
        • Not yet recruiting
        • Hospital Juarez de Mexico
        • Principal Investigator:
          • Eumir Juarez-Valdes
      • Mexico City, Mexico, 06100
        • Not yet recruiting
        • Keystone Clinical Trials
        • Principal Investigator:
          • Karina Olvera
      • Monterrey, Mexico, 66220
        • Not yet recruiting
        • Servicios de Oncología Médica Integral - Monterrey
        • Principal Investigator:
          • Manuel Martinez Vazquez
      • Querétaro, Mexico, 76088
        • Not yet recruiting
        • Centro de Investigación Clinica Chapultepec
        • Principal Investigator:
          • Raul Chavez Ayala
  • Poland
      • Chorzów, Poland, 41-500
        • Not yet recruiting
        • M2M Med
        • Contact:
          • Phone Number: +48 518 424 470
        • Principal Investigator:
          • Magdalena Wloch-Targonska
      • Katowice, Poland, 40-600
        • Not yet recruiting
        • Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero
        • Principal Investigator:
          • Marek Olakowski
      • Kielce, Poland, 25-355
        • Not yet recruiting
        • Polimedica PTG Kielce
        • Principal Investigator:
          • Dariusz Solowiej
      • Krakow, Poland, 31-228
        • Not yet recruiting
        • Oslomed Centrum Medyczne
        • Principal Investigator:
          • Anna Drozdz
      • Lodz, Poland, 90-302
        • Not yet recruiting
        • Santa Familia PTG Lodz
        • Principal Investigator:
          • Aleksandra Sobolewska-Wlodarczyk
      • Poznan, Poland, 60-324
        • Not yet recruiting
        • Twoja Przychodnia PCM
        • Contact:
          • Phone Number: +48 724 444 299
        • Principal Investigator:
          • Ewa Furmanowska-Ladorska
      • Siedlce, Poland, 08-110
        • Not yet recruiting
        • ETG Siedlce
        • Principal Investigator:
          • Anna Lewandowska
      • Szczecin, Poland, 71-434
        • Not yet recruiting
        • Twoja Przychodnia SCM
        • Principal Investigator:
          • Beata Gawdis-Wojnarska
        • Contact:
          • Phone Number: 48 91 433 29 19
      • Szczecin, Poland, 71-685
        • Not yet recruiting
        • Sonomed Sp. z o. o.
        • Principal Investigator:
          • Anna Wiechowska-Kozlowska
      • Warsaw, Poland, 04-501
        • Not yet recruiting
        • Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
        • Principal Investigator:
          • Jaroslaw Kierkus
        • Contact:
          • Phone Number: 500111648
      • Warsaw, Poland, 00-710
        • Not yet recruiting
        • Clinical Best Solutions
        • Principal Investigator:
          • Michal Lawinski
      • Zamość, Poland, 22-400
        • Not yet recruiting
        • ETG Zamosc
        • Principal Investigator:
          • Katarzyna Wojcik
        • Contact:
          • Phone Number: 48606930022
  • Portugal
      • Braga, Portugal, 4710-243
        • Not yet recruiting
        • 2Ca Braga
        • Principal Investigator:
          • Bruno Arroja
      • Lisbon, Portugal, 1500-650
        • Not yet recruiting
        • Hospital da Luz Lisboa
        • Principal Investigator:
          • Lidia Ramos
      • Lisbon, Portugal, 1649-035
        • Not yet recruiting
        • Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria
        • Principal Investigator:
          • Samuel Fernandes
      • Santa Maria da Feira, Portugal, 4520-211
        • Not yet recruiting
        • Unidade Local de Saúde Entre o Douro e Voga
        • Contact:
          • Phone Number: 351256379733
        • Principal Investigator:
          • Rute Cerqueira
  • Puerto Rico
      • San Juan, Puerto Rico, 00909
        • Not yet recruiting
        • Pan American Center for Oncology Trials - Ciudadela
        • Contact:
          • Phone Number: 787-407-3333
        • Principal Investigator:
          • Juan Marques Lespier
      • San Juan, Puerto Rico, 00935
        • Not yet recruiting
        • Adult University Hospital
        • Contact:
          • Phone Number: 787-7540101x5420
        • Principal Investigator:
          • Esther Torres
  • Serbia
      • Belgrade, Serbia, 11000
        • Not yet recruiting
        • MSB General Hospital
        • Principal Investigator:
          • Dragan Tomic
      • Leskovac, Serbia, 16000
        • Not yet recruiting
        • Leskovac General Hospital
        • Principal Investigator:
          • Tomislav Tasic
      • Sremska Mitrovica, Serbia, 22000
        • Not yet recruiting
        • Sremska Mitrovica Health Centre
        • Principal Investigator:
          • RADOVAN ZEC
      • Zrenjanin, Serbia, 23000
        • Not yet recruiting
        • General Hospital "Djordje Joanovic"
        • Principal Investigator:
          • Tatjana Latinovic Radakovic
  • Slovakia
      • Bratislava, Slovakia, 81109
        • Not yet recruiting
        • Cliniq s.r.o.
        • Principal Investigator:
          • Tibor Hlavaty
        • Contact:
          • Phone Number: +421917752297
      • Bratislava, Slovakia, 821 01
        • Not yet recruiting
        • Gastroentero s.r.o.
        • Contact:
          • Phone Number: +421907798994
        • Principal Investigator:
          • Vladimir Klinovsky
      • Prešov, Slovakia, 080 01
        • Not yet recruiting
        • GASTRO I., s.r.o.
        • Principal Investigator:
          • Bohus Bunganic
        • Contact:
          • Phone Number: +421903607349
      • Rimavská Sobota, Slovakia, 979 01
        • Not yet recruiting
        • Vseobecna nemocnica Rimavska Sobota
        • Principal Investigator:
          • Jan Zachar
        • Contact:
          • Phone Number: +421 905 218 417
      • Šahy, Slovakia, 936 01
        • Not yet recruiting
        • Accout Center
        • Principal Investigator:
          • Frantisek Horvath
        • Contact:
          • Phone Number: +421 918 477 281
  • South Africa
      • Bloemfontein, South Africa, 9301
        • Not yet recruiting
        • Iatros International
        • Principal Investigator:
          • Wayne Simmonds
      • Cape Town, South Africa, 7500
        • Not yet recruiting
        • Mediclinic Panorama
        • Contact:
          • Phone Number: +27219300923
        • Principal Investigator:
          • Maarten Prins
      • Cape Town, South Africa, 7700
        • Not yet recruiting
        • Spoke Research
        • Contact:
          • Phone Number: +27832844682
        • Principal Investigator:
          • Malgorzata George
      • Johannesburg, South Africa, 1821
        • Not yet recruiting
        • Lenasia Clinical Trial Centre - Johannesburg
        • Principal Investigator:
          • Nazeer Chopdat
      • Kempton Park, South Africa, 1619
        • Not yet recruiting
        • Clinresco Centres
        • Principal Investigator:
          • Jennifer Rosa
  • South Korea
      • Busan, South Korea, 50612
        • Not yet recruiting
        • Pusan National University Yangsan Hospital
        • Principal Investigator:
          • Su Bum Park
      • Busan, South Korea, 49201
        • Not yet recruiting
        • Dong-A University Hospital
        • Principal Investigator:
          • Jonghun Lee
      • Daegu, South Korea, 41944
        • Not yet recruiting
        • Kyungpook National University Hospital
        • Principal Investigator:
          • Eunsoo Kim
      • Daejeon, South Korea, 34943
        • Not yet recruiting
        • The Catholic University of Korea, Daejeon St. Mary's Hospital
        • Principal Investigator:
          • Sang-Bum Kang
        • Contact:
          • Phone Number: 82422209501
      • Gwangju, South Korea, 61453
        • Not yet recruiting
        • Chosun university hospital
        • Principal Investigator:
          • Jun Lee
      • Gyeongsan-si, South Korea, 42415
        • Not yet recruiting
        • Yeungnam Univeristy Medical Center
        • Principal Investigator:
          • BYUNGIK JANG
        • Contact:
          • Phone Number: 82-53-620-3830
      • Pusan, South Korea, 48108
        • Not yet recruiting
        • Inje University Haeundae Paik Hospital
        • Principal Investigator:
          • Tae Oh Kim
        • Contact:
          • Phone Number: 82-51-797-0220
      • Seoul, South Korea, 03312
        • Not yet recruiting
        • The Catholic University of Korea, Eunpyeong St. Mary's Hospital
        • Principal Investigator:
          • Sung Hoon Jung
      • Seoul, South Korea, 03080
        • Not yet recruiting
        • Seoul National University Hospital
        • Principal Investigator:
          • Seongjoon Koh
        • Contact:
          • Phone Number: 027408112
      • Seoul, South Korea, 03722
        • Not yet recruiting
        • Severance Hospital, Yonsei University Health System
        • Principal Investigator:
          • Jae Hee Cheon
      • Seoul, South Korea, 03181
        • Not yet recruiting
        • Kangbuk Samsung Hospital
        • Principal Investigator:
          • Dong Il Park
      • Seoul, South Korea, 06351
        • Not yet recruiting
        • Samsung Medical Center
        • Principal Investigator:
          • YoungHo Kim
      • Seoul, South Korea, 02447
        • Not yet recruiting
        • Kyung Hee University Hospital
        • Principal Investigator:
          • Chang Kyun Lee
      • Wŏnju, South Korea, 26426
        • Not yet recruiting
        • Wonju Severance Christian Hospital
        • Principal Investigator:
          • Hyun Soo Kim
  • Taiwan
      • Changhua, Taiwan, 50006
        • Not yet recruiting
        • Changhua Christian Hospital
        • Principal Investigator:
          • Hsu-Heng Yen
      • Kaohsiung City, Taiwan, 807
        • Not yet recruiting
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Principal Investigator:
          • Deng-Chyang Wu
      • Taichung, Taiwan, 404332
        • Not yet recruiting
        • China Medical University Hospital
        • Principal Investigator:
          • Jen-Wei Chou
      • Taipei, Taiwan, 10002
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Shu-Chen Wei
      • Taipei, Taiwan, 114
        • Not yet recruiting
        • Tri-Service General Hospital
        • Principal Investigator:
          • Tien-Yu Huang
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01250
        • Not yet recruiting
        • Bakent University, Adana Clinic & Research Ctr.
        • Contact:
          • Phone Number: +905325467187
        • Principal Investigator:
          • Birol Ozer
      • Ankara, Turkey (Türkiye), 06230
        • Not yet recruiting
        • Hacettepe Universite Hastaneleri
        • Principal Investigator:
          • Muhammed Durak
      • Antalya, Turkey (Türkiye), 07100
        • Not yet recruiting
        • Antalya Egitim ve Arastırma Hastanesi
        • Principal Investigator:
          • Ayhan Hilmi Cekin
      • Bornova, Turkey (Türkiye), 35100
        • Not yet recruiting
        • Ege Universitesi Hastanesi
        • Principal Investigator:
          • Nalan Unal
        • Contact:
          • Phone Number: +90 505 782 38 08
      • Hatay, Turkey (Türkiye), 31030
        • Not yet recruiting
        • Mustafa Kemal Universitesi
        • Principal Investigator:
          • Mehmet Demir
      • Istanbul, Turkey (Türkiye), 34093
        • Not yet recruiting
        • Bezmialem Vakf Üniversitesi
        • Principal Investigator:
          • Metin Basaranoglu
      • Mersin, Turkey (Türkiye), 33110
        • Not yet recruiting
        • Mersin University
        • Principal Investigator:
          • Engin Altintas
        • Contact:
          • Phone Number: 905326145276
      • İzmit, Turkey (Türkiye), 41380
        • Not yet recruiting
        • Kocaeli University Medical Faculty Hospital
        • Principal Investigator:
          • Ali Duman
  • Ukraine
      • Chernivtsi, Ukraine, 58000
        • Not yet recruiting
        • Chernivtsi Regional Clinical Hospital
        • Contact:
          • Phone Number: +380503741659
        • Principal Investigator:
          • Oleksandr Fediv
      • Kiev, Ukraine, 04050
        • Not yet recruiting
        • Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
        • Principal Investigator:
          • Oksana Gerasymenko
        • Contact:
          • Phone Number: +380979132763
      • Kyiv, Ukraine, 04210
        • Not yet recruiting
        • Center of Family Medicine Plus
        • Principal Investigator:
          • Liudmyla Chupryna
        • Contact:
          • Phone Number: +380972094524
      • Kyiv, Ukraine, 02002
        • Not yet recruiting
        • Edelweiss Medics
        • Contact:
          • Phone Number: +380445949200
        • Principal Investigator:
          • Oleksandra Bilotkach
      • Kyiv, Ukraine, 02091
        • Not yet recruiting
        • Medical Center Ok!Clinic+
        • Principal Investigator:
          • Nataliia Tsarynna
        • Contact:
          • Phone Number: +380937694807
      • Kyiv, Ukraine, 03037
        • Not yet recruiting
        • Medbud Clinic
        • Contact:
          • Phone Number: 380445947078
        • Principal Investigator:
          • Dmytro Donets
      • Kyiv, Ukraine, 04106
        • Not yet recruiting
        • Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"
        • Principal Investigator:
          • Svitlana Danyliuk
        • Contact:
          • Phone Number: +380506381700
      • Lviv, Ukraine, 79019
        • Not yet recruiting
        • Progastro Clinic
        • Principal Investigator:
          • Olha Ivanishyn
        • Contact:
          • Phone Number: 0933825853
      • Uzhhorod, Ukraine, 88018
        • Not yet recruiting
        • Transcarpathian Regional Hospital im.Andriya Novak
        • Principal Investigator:
          • Yaroslava Rishko
        • Contact:
          • Phone Number: +380997279631
      • Vinnytsia, Ukraine, 21029
        • Not yet recruiting
        • Communal Non-Commercial Enterprise "Vinnytsia City Clinical Hospital #1"
        • Principal Investigator:
          • Nataliia Pentiuk
        • Contact:
          • Phone Number: +380676222307
  • United States
    • Arizona
      • Phoenix, Arizona, United States, 85008
        • Not yet recruiting
        • Valleywise Health Medical Center
        • Contact:
          • Phone Number: 602-344-5194
        • Principal Investigator:
          • Indu Srinivasan
      • Scottsdale, Arizona, United States, 85258
        • Not yet recruiting
        • One of a Kind Clinical Research Center
        • Principal Investigator:
          • Florin Gaidici
        • Contact:
          • Phone Number: 602-820-6906
    • California
      • Anaheim, California, United States, 92805
        • Recruiting
        • Clinnova Research
        • Principal Investigator:
          • Amit Bhanvadia
      • Folsom, California, United States, 95630
        • Recruiting
        • GMC Clinical Research
        • Principal Investigator:
          • Nazir Rahim
      • Temple City, California, United States, 91780
        • Not yet recruiting
        • Om Research LLC
        • Contact:
          • Phone Number: 661-388-2239
        • Principal Investigator:
          • Ken Nguyen
      • Victorville, California, United States, 92395
        • Not yet recruiting
        • Om Research LLC
        • Contact:
          • Phone Number: 661-388-2239
        • Principal Investigator:
          • Nikhil Gupta
    • Colorado
      • Colorado Springs, Colorado, United States, 80907
        • Recruiting
        • Peak Gastroenterology Associates
        • Principal Investigator:
          • Bhaktasharan Patel
        • Contact:
          • Phone Number: 719-310-6719
      • Denver, Colorado, United States, 80218
        • Not yet recruiting
        • Advanced Research Institute - Denver
        • Contact:
          • Phone Number: 303-353-2660
        • Principal Investigator:
          • Joshua Steinberg
      • Lakewood, Colorado, United States, 80228
        • Recruiting
        • Rocky Mountain Gastroenterology Associates - Lakewood
        • Principal Investigator:
          • Rajesh Jain
    • Connecticut
      • Hamden, Connecticut, United States, 06518
        • Not yet recruiting
        • Medical Research Center of Connecticut
        • Principal Investigator:
          • Paul Feuerstadt
    • Florida
      • Daytona Beach, Florida, United States, 32114
        • Not yet recruiting
        • K2 Medical Research - Daytona Beach
        • Principal Investigator:
          • Esteban Olivera
      • Kissimmee, Florida, United States, 34741
        • Recruiting
        • Clinical Research of Osceola
        • Principal Investigator:
          • Basher Atiquzzaman
        • Contact:
          • Phone Number: 407-954-4016
      • Lakewood Rch, Florida, United States, 34211
        • Recruiting
        • Florida Research Institute
        • Contact:
          • Phone Number: 941-727-7772
        • Principal Investigator:
          • Manuel Rodriguez
      • Orlando, Florida, United States, 32803
        • Not yet recruiting
        • AdventHealth Orlando
        • Principal Investigator:
          • Jennifer Seminerio Diehl
        • Contact:
          • Phone Number: 407-303-9921
    • Idaho
      • Boise, Idaho, United States, 83706
        • Not yet recruiting
        • Treasure Valley Medical Research
        • Principal Investigator:
          • Neetu Talreja
        • Contact:
          • Phone Number: 208-813-6505
      • Idaho Falls, Idaho, United States, 83404
        • Not yet recruiting
        • Grand Teton Research Group
        • Contact:
          • Phone Number: 208-528-4256
        • Principal Investigator:
          • Todd Williams
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Not yet recruiting
        • Northwestern University
        • Principal Investigator:
          • Keith Summa
        • Contact:
          • Phone Number: 312-695-4077
      • Chicago, Illinois, United States, 60612
        • Not yet recruiting
        • Rush University Medical Center
        • Principal Investigator:
          • Atsushi Sakuraba
      • Des Plaines, Illinois, United States, 60016
        • Recruiting
        • Midwest Digestive Health & Nutrition
        • Contact:
          • Phone Number: 312-767-3244
        • Principal Investigator:
          • Amar Naik
      • Springfield, Illinois, United States, 62702
        • Recruiting
        • Springfield Clinic - First
        • Contact:
          • Phone Number: 217-528-7541
        • Principal Investigator:
          • Rajan Kochar
    • Indiana
      • New Albany, Indiana, United States, 47150
        • Recruiting
        • Gastroenterology Health Partners
        • Contact:
          • Phone Number: 812-206-1702
        • Principal Investigator:
          • Jonathan Obert
    • Kentucky
      • Louisville, Kentucky, United States, 40218
        • Recruiting
        • Gastroenterology Health Partners
        • Principal Investigator:
          • Michael Krease
        • Contact:
          • Phone Number: 502-888-1988
    • Michigan
      • Wyoming, Michigan, United States, 49519
        • Recruiting
        • Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
        • Principal Investigator:
          • Allan Coates
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Not yet recruiting
        • Mayo Clinic in Rochester, Minnesota
        • Principal Investigator:
          • Amanda Johnson
    • Missouri
      • St Louis, Missouri, United States, 63123
        • Not yet recruiting
        • KAD Clinical Research
        • Principal Investigator:
          • Adrian Di Bisceglie
        • Contact:
          • Phone Number: 314-254-3168
    • Nevada
      • Las Vegas, Nevada, United States, 89128
        • Recruiting
        • Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive
        • Principal Investigator:
          • Michael Zimmerman
    • New Jersey
      • Moorestown, New Jersey, United States, 08057
        • Not yet recruiting
        • Virtua Health & Wellness Center - Moorestown
        • Principal Investigator:
          • Sanket Patel
      • New Brunswick, New Jersey, United States, 08901
        • Not yet recruiting
        • Saint Peter's University Hospital
        • Principal Investigator:
          • Arkady Broder
    • New York
      • Stony Brook, New York, United States, 11794
        • Not yet recruiting
        • Stony Brook University
        • Principal Investigator:
          • Lasha Gogokhia
    • North Carolina
      • Greenville, North Carolina, United States, 27834
        • Recruiting
        • Carolina Digestive Diseases and Endoscopy Center
        • Contact:
          • Phone Number: 252-758-8181
        • Principal Investigator:
          • Phillip Goldstein
      • Wilmington, North Carolina, United States, 28401
        • Recruiting
        • Wilmington Health, PLLC
        • Principal Investigator:
          • Ashok Shiani
    • Ohio
      • Hilliard, Ohio, United States, 43026
        • Not yet recruiting
        • Ohio State University
        • Principal Investigator:
          • Jacob Skeans
      • Springboro, Ohio, United States, 45066
        • Not yet recruiting
        • DSI Research - Springboro
        • Principal Investigator:
          • Anjali Morey
      • Westlake, Ohio, United States, 44145
        • Not yet recruiting
        • Gastro Intestinal Research Institute of Northern Ohio, LLC
        • Contact:
          • Phone Number: 440-250-7630
        • Principal Investigator:
          • Mohamed Naem
    • Oregon
      • Portland, Oregon, United States, 97220
        • Not yet recruiting
        • The Oregon Clinic
        • Principal Investigator:
          • Phillip Kiyasu
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Not yet recruiting
        • Medical University of South Carolina
        • Contact:
          • Phone Number: 843-792-3710
        • Principal Investigator:
          • Erin Forster
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57105
        • Not yet recruiting
        • Sanford USD Medical Center
        • Principal Investigator:
          • Ahmed Kurdi
    • Texas
      • Fort Worth, Texas, United States, 76104
        • Recruiting
        • GI Alliance - Fort Worth
        • Principal Investigator:
          • Kumar Gutta
        • Contact:
          • Phone Number: 817-612-5575
      • Garland, Texas, United States, 75044
        • Recruiting
        • GI Alliance - Garland
        • Principal Investigator:
          • Harry Sarles
        • Contact:
          • Phone Number: 972-265-8201
      • Houston, Texas, United States, 77090
        • Recruiting
        • Integrity Advanced Therapeutics
        • Principal Investigator:
          • Howard Hamat
        • Contact:
          • Phone Number: 281-453-2005
      • Mansfield, Texas, United States, 76063
        • Recruiting
        • GI Alliance: Mansfield
        • Principal Investigator:
          • MOUSTAFA YOUSSEF
        • Contact:
          • Phone Number: 817-417-9664
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • Southern Star Research Institute
        • Contact:
          • Phone Number: 210-581-2812
        • Principal Investigator:
          • Jeff Bullock
      • San Marcos, Texas, United States, 78666
        • Recruiting
        • GI Alliance - San Marcos
        • Principal Investigator:
          • Thomas Kepczyk
        • Contact:
          • Phone Number: 512-878-1100
      • Tyler, Texas, United States, 75701
        • Not yet recruiting
        • Tyler Research Institute
        • Principal Investigator:
          • George Duvall
        • Contact:
          • Phone Number: 903-630-6211
    • Virginia
      • Norfolk, Virginia, United States, 23502
        • Recruiting
        • Eximia Research-VA, LLC
        • Principal Investigator:
          • John Smith
    • Washington
      • Seattle, Washington, United States, 98104
        • Not yet recruiting
        • Swedish Medical Center
        • Principal Investigator:
          • Jason Harper
      • Spokane, Washington, United States, 99202
        • Not yet recruiting
        • Principle Research Solutions
        • Principal Investigator:
          • Harold Preiksaitis
        • Contact:
          • Phone Number: 590-474-1107
      • Spokane, Washington, United States, 99208
        • Not yet recruiting
        • Providence Sacred Heart Medical Center & Children's Hospital
        • Contact:
          • Phone Number: 509-489-2600
        • Principal Investigator:
          • Eashen Liu
      • Tacoma, Washington, United States, 98405
        • Recruiting
        • Washington Gastroenterology - Tacoma
        • Principal Investigator:
          • William Holderman
        • Contact:
          • Phone Number: 253-272-5127

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have had an established diagnosis of ulcerative colitis (UC) for ≥3 months prior to randomization, which includes endoscopic evidence of UC
  • Have moderately to severely active UC defined by a Modified Mayo Score (mMS) of 5 to 9 with an Endoscopic Score (ES)≥2 confirmed by central reader and rectal bleeding (RB)≥1
  • Have evidence of UC extending proximal to the rectum
  • Have documented evidence of having had a surveillance colonoscopy within 1 year, or according to local guidelines, to evaluate for polyps, dysplasia, or malignancy, prior to randomization, if the participant has a history of UC symptoms for more than 8 years
  • Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators). Participants with inadequate response to vedolizumab are excluded
  • Must meet contraception requirements

Exclusion Criteria:

  • Have a current diagnosis of

    • Crohn's disease
    • Inflammatory Bowel Disease (IBD unclassified) (formerly known as indeterminate colitis), or
    • primary sclerosing cholangitis
  • Have an inherited immunodeficiency syndrome or known monogenic cause of UC-like colonic inflammation
  • Have had or will need bowel resection or intestinal or intra-abdominal surgery
  • Have evidence of toxic megacolon, intra-abdominal abscess, or stricture or stenosis within small bowel or colon that cannot be traversed by a colonoscope or that are symptomatic
  • Have any prior or current evidence of cancer gastrointestinal (GI) tract, or specified lesions with increased risk of GI malignancies
  • Have a diagnosis or history of malignant disease within 5 years prior to randomization

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: LY4268989 Study Dose 1
LY4268989 administered orally
Drug: LY4268989
Administered orally
Other Names:
  • MORF-057
  • zotemtegrast
Experimental: LY4268989 Study Dose 2
LY4268989 administered orally
Drug: LY4268989
Administered orally
Other Names:
  • MORF-057
  • zotemtegrast
Placebo Comparator: Placebo Study Dose
Placebo administered orally
Drug: Placebo
Administered orally

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percentage of Participants Who Achieve Clinical Remission with Modified Mayo Score (mMS)
Time Frame: Week 10
Week 10
Percentage of Participants Who Achieve Clinical Remission with mMS Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Time Frame: Week 52
Week 52

Secondary Outcome Measures

Outcome Measure
Time Frame
Percentage of Participants Who Achieve Clinical Response with mMS
Time Frame: Week 10
Week 10
Percentage of Participants Who Achieve Clinical Response with mMS Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Time Frame: Week 10 Up to Week 52
Week 10 Up to Week 52
Percentage of Participants Who Achieve Symptomatic Response
Time Frame: Baseline Up to Week 8
Baseline Up to Week 8
Percentage of Participants Who Achieve Symptomatic Response Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Time Frame: Week 10 Up to Week 52
Week 10 Up to Week 52
Pharmacokinetics (PK): Plasma Concentrations of LY4268989
Time Frame: Baseline Up to Approximately Week 52
Baseline Up to Approximately Week 52
Percentage of Participants Who Achieve Clinical Remission Among Participants Who Achieved Clinical Remission with LY4268989 at Week 10
Time Frame: Week 52
Week 52

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 26, 2026

Primary Completion (Estimated)

June 1, 2030

Study Completion (Estimated)

July 1, 2031

Study Registration Dates

First Submitted

February 6, 2026

First Submitted That Met QC Criteria

February 11, 2026

First Posted (Actual)

February 17, 2026

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 20, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27589
  • J6E-MC-KWAM (Other Identifier: Eli Lilly and Company)
  • EU Trial (CTIS) Number (Other Identifier: 2025-524404-29-00)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and European Union (EU), whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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