LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction

May 6, 2026 updated by: Hesham Nabil Ali Al-Qamhawy

Effectiveness of Piezocision Versus Low-level Laser Therapy During Orthodontic Canine Retraction: A Comparative Controlled Clinical Study

This comparative controlled clinical study aims to evaluate and compare the effectiveness of piezocision and low-level laser therapy (LLLT) as adjunctive interventions to accelerate orthodontic canine retraction. Participants will be randomly assigned to one of three groups: piezocision, LLLT, or a control group (no adjunctive procedure). The study will assess the impact of these interventions on the rate of tooth movement, the type of tooth movement, and patient experience.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Cairo Governorate
      • Cairo, Cairo Governorate, Egypt
        • Recruiting
        • Outpatient Clinics of the Department of Orthodontics, Faculty of Dental Medicine, Boys, Cairo, Al-Azhar University.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age range 18-25 years.
  • Patients with crowding or protrusion requiring at least bilateral maxillary first premolar extraction followed by symmetrical canine retraction.
  • Full set of permanent dentition (third molar not considered).
  • Patients with good oral hygiene.

Exclusion Criteria:

  • Previous orthodontic treatment.
  • Patients taking medications or suffering from systemic conditions that can affect orthodontic tooth movement.
  • Active periodontal diseases and/or untreated carious lesions.
  • Congenital orofacial deformities.

Discontinuation criteria:

  • Multiple missing appointments.
  • Poor oral hygiene.
  • Multiple broken appliances to the extent that interferes with obtaining the treatment objectives.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Control group
Experimental: Low-level laser therapy group
Procedure: Low Level Laser Therapy
On both right and left sides, LLLT will be performed at the beginning of canine retraction, after 3, 7, 14 days, and then every 14 days for a total four-month period.
Other Names:
  • LLLT
Experimental: Piezocision group
Procedure: Piezocision
On both right and left sides, a minimally invasive flapless piezocision procedure will be performed each month from the beginning of the canine retraction for a total four-month period.
Other Names:
  • Piezosurgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Rate of canine retraction
Time Frame: Four months from the beginning of maxillary canine retraction.
The rate of distal movement of the maxillary canine measured in millimeters per month (mm/month).
Four months from the beginning of maxillary canine retraction.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Maxillary canine rotation and tipping.
Time Frame: Four months from the beginning of maxillary canine retraction.
Measured in degrees
Four months from the beginning of maxillary canine retraction.
Maxillary first molar mesial movement
Time Frame: Four months from the beginning of maxillary canine retraction.
Maxillary first molar mesial movement (measured in mm)
Four months from the beginning of maxillary canine retraction.
Maxillary first molar rotatiob
Time Frame: Four months from the beginning of maxillary canine retraction.
(measured in degrees).
Four months from the beginning of maxillary canine retraction.
Patient-Reported Pain Intensity
Time Frame: Four months from the beginning of maxillary canine retraction.
Pain intensity will be measured using a 10-centimeter Visual Analogue Scale (VAS). The scale ranges from 0 to 10, where 0 represents "no pain" and 10 represents "the worst possible pain" . Therefore, higher scores indicate a worse outcome (greater pain intensity).
Four months from the beginning of maxillary canine retraction.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hesham Nabil Ali Al-Qamhawy

Collaborators

Al-Azhar University

Investigators

  • Study Chair: Farouk A Hussein, Professor, Professor in Orthodontics; Faculty of Dental Medicine, Boys, Cairo; Al-Azhar University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2026

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

June 1, 2027

Study Registration Dates

First Submitted

March 3, 2026

First Submitted That Met QC Criteria

March 10, 2026

First Posted (Actual)

March 12, 2026

Study Record Updates

Last Update Posted (Actual)

May 11, 2026

Last Update Submitted That Met QC Criteria

May 6, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1440/1511

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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