Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery

Incremental Prognostic Value of Frailty Beyond the Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery: A Prospective Cohort Study

Hip fractures are serious injuries that occur mostly in older adults. Many people experience health problems or may die in the months after surgery. Doctors try to identify patients who have a higher risk of poor outcomes as early as possible.

Doctors often use the Nottingham Hip Fracture Score (NHFS) to estimate the risk of death after hip fracture surgery. This score uses information such as age and other health conditions. However, it does not fully reflect how physically vulnerable a person may be.

Another important concept is frailty. Frailty describes how strong or weak a person's overall health and physical reserve are. In this study, frailty will be measured using the Clinical Frailty Scale (CFS). This scale evaluates a person's level of independence and physical function before the fracture.

The purpose of this study is to determine whether measuring frailty can improve the prediction of death after hip fracture surgery.

Older adults with hip fractures who undergo surgery will be invited to participate in the study. Researchers plan to include about 200 participants or all eligible patients enrolled within one year, whichever occurs first. Health information that is already collected during routine hospital care will be recorded. Frailty will be assessed when participants are admitted to the hospital.

Participants will be followed for 30 days and 90 days after surgery to determine survival status. Researchers will review hospital records and may contact participants or their relatives by phone if needed.

The results of this study may help doctors better identify patients at higher risk and improve care planning after hip fracture surgery.

Study Overview

• Status: Recruiting
• Conditions: Frailty; Hip Fracture; Proximal Femur Fracture
• Intervention / Treatment: Other: No Intervention: Observational Cohort

Detailed Description

Hip fractures in older adults are associated with substantial morbidity, loss of independence, and high early mortality. Identifying patients at increased risk of poor outcomes is therefore an important part of perioperative care and treatment planning. Several clinical tools have been developed to estimate short-term mortality following hip fracture surgery. Among these, the Nottingham Hip Fracture Score (NHFS) is widely used and has been validated in multiple patient cohorts.

The NHFS is calculated using routinely available clinical variables such as age, comorbid conditions, and laboratory values. Although this score performs reasonably well in predicting short-term mortality, it mainly reflects comorbidity burden and demographic factors. It does not directly measure the patient's physiological reserve or overall vulnerability to stress.

Frailty has gained increasing attention as an important determinant of surgical outcomes in older adults. Frailty represents a state of reduced physiological reserve that limits the ability to recover from acute health events such as trauma or surgery. The Clinical Frailty Scale (CFS) is a practical bedside tool that classifies frailty based on functional status and the level of independence prior to illness or injury. Because it can be applied quickly in routine clinical settings, it has been used in various studies evaluating outcomes in geriatric populations.

Despite growing interest in frailty assessment, its added value when combined with established hip fracture risk scores remains uncertain. In particular, there is limited prospective evidence examining whether frailty assessment improves mortality prediction beyond existing tools such as the NHFS.

This prospective observational cohort study will collect standardized clinical data from older adults undergoing surgical treatment for proximal femoral fractures. Frailty will be assessed at hospital admission using the Clinical Frailty Scale based on the participant's functional status before the fracture. The Nottingham Hip Fracture Score will be calculated from routinely recorded clinical variables.

The analysis will examine the relationship between NHFS, frailty status, and short-term mortality following surgery. Predictive models including NHFS alone will be compared with models that incorporate both NHFS and frailty status in order to determine whether frailty provides additional prognostic information.

Understanding whether frailty assessment improves risk prediction may help clinicians identify vulnerable patients earlier and support more individualized perioperative management in older adults with hip fractures.

• Study Type: Observational
• Enrollment (Estimated): 200

Contacts and Locations

• Study Contact: Name: Eşref SELÇUK Asst Prof, MD; Phone Number: +905356319974; Email: trkesref@hotmail.com

Study Locations

• Turkey (Türkiye)
  • Edirne, Turkey (Türkiye)
    • Recruiting
    • Trakya University
    • Contact: Eşref Selçuk Asst Prof Selçuk, MD; Phone Number: +905356319974

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Older adults admitted with proximal femoral fractures who undergo surgical treatment at Trakya University Hospital.

Description

Inclusion Criteria:

• Age 60 years or older
• Admission for acute proximal femoral fracture (femoral neck, intertrochanteric, or subtrochanteric fracture)
• Surgical treatment for hip fracture
• Ability to obtain clinical data required for NHFS and frailty assessment

Exclusion Criteria:

• Pathological fractures
• Periprosthetic fractures
• Hip fractures resulting from high-energy trauma or polytrauma
• Non-operative treatment
• Second hip fracture occurring in the same patient during the study period

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Hip Fracture Surgery Cohort; Older adults aged 60 years or older who undergo surgical treatment for proximal femoral fractures. Frailty will be assessed using the Clinical Frailty Scale and mortality outcomes will be evaluated at 30 and 90 days after surgery.	Other: No Intervention: Observational Cohort; no intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
90 Day All Cause Mortality	All cause mortality occurring within 90 days after hip fracture surgery.	90 days after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
30 Day All Cause Mortality	All cause mortality occurring within 30 days after hip fracture surgery.	30 days after surgery
Postoperative complications		90 days after surgery
Length of hospital stay		From hospital admission to hospital discharge (up to 30 days)

Collaborators and Investigators

• Sponsor: Trakya University

Publications and helpful links

General Publications

• Maxwell MJ, Moran CG, Moppett IK. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. Br J Anaesth. 2008 Oct;101(4):511-7. doi: 10.1093/bja/aen236. Epub 2008 Aug 21.
• Narula S,Lawless A,D'Alessandro P,Jones CW,Yates P,Seymour H
• Kennedy MJ,Penfold RS,Donaldson L,Hall AJ,Davison MJ,MacLullich AMJ,Walmsley P,Clement ND,Clarke JV

Study record dates

Study Major Dates

• Study Start (Actual): March 15, 2026
• Primary Completion (Estimated): March 15, 2027
• Study Completion (Estimated): March 15, 2027

Study Registration Dates

• First Submitted: March 11, 2026
• First Submitted That Met QC Criteria: March 16, 2026
• First Posted (Actual): March 18, 2026

Study Record Updates

• Last Update Posted (Actual): March 31, 2026
• Last Update Submitted That Met QC Criteria: March 25, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: Frailty; Mortality prediction; Hip fracture; Proximal femur fracture; Geriatric fracture
• Additional Relevant MeSH Terms: Wounds and Injuries; Pathologic Processes; Leg Injuries; Fractures, Bone; Femoral Fractures; Hip Injuries; Pathological Conditions, Signs and Symptoms; Femoral Neck Fractures; Frailty; Hip Fractures; Proximal Femoral Fractures
• Other Study ID Numbers: TÜTF-GOBAEK 2026/81

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No