Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury

Weaning Outcomes in Patients With Acute Brain Injury Based on CDIC

Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.

Study Overview

• Status: Withdrawn
• Conditions: Mechanical Ventilation; Acute Brain Injuries

• Study Type: Observational

Contacts and Locations

Study Locations

• China
  • Jiangsu
    • Nanjing, Jiangsu, China, 210009
      • Department of Critical Care Medicine, Zhongda Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients with ABI including traumatic brain injury (TBI), non-traumatic intracranial hemorrhage (ICH), subarachnoid aneurysmal hemorrhage (SAH), acute ischemic stroke (AIS), and central nervous system infection were eligible to this study, if they were ≥ 18 years old and underwent IMV for at least 24 hours

Description

Inclusion Criteria:

• Patients with ABI
• ≥ 18 years old
• underwent IMV for at least 24 hours

Exclusion Criteria:

• already tracheostomized
• concurrent of cervical spinal cord injury
• pregnant or lactation
• withdraw of life-sustaining treatment within the first 24 hours of ICU admission

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Classified by weaning outcomes

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
weaning outcome	The primary endpoint was the weaning outcome according to the modified WIND classification	day 90

Collaborators and Investigators

• Sponsor: Southeast University, China

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2018
• Primary Completion (Actual): December 31, 2025
• Study Completion (Estimated): March 1, 2026

Study Registration Dates

• First Submitted: March 22, 2026
• First Submitted That Met QC Criteria: March 22, 2026
• First Posted (Actual): March 27, 2026

Study Record Updates

• Last Update Posted (Actual): June 8, 2026
• Last Update Submitted That Met QC Criteria: June 4, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Wounds and Injuries; Craniocerebral Trauma; Trauma, Nervous System; Brain Injuries
• Other Study ID Numbers: Retro WEAN ABI

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No