A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity (HF-POLARIS)

April 28, 2026 updated by: Novo Nordisk A/S

Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

5610

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Novo Nordisk
Phone Number: (+1) 866-867-7178
Email: clinicaltrials@novonordisk.com

Study Locations

Argentina
- - Buenos Aires, Argentina, C1426ABP
    - Fundación Respirar
  - Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
  - Buenos Aires, Argentina, C1221ADC
    - Cardiología Hospital J. M. Ramos Mejia
  - CABA, Argentina, C1430CKE
    - Glenny Corp. S.A
  - CABA, Argentina, C1060ABA
    - CEDIC Centro de Investigación Clínica
  - Capital Federal, Argentina, C1056ABI
    - Centro de Investigaciones Metabólicas
  - Córdoba, Argentina, 5000
    - Instituto de Investigaciones Clinicas Cordoba
  - Córdoba, Argentina, 5000
    - Clínica Privada Vélez Sarsfield
  - Córdoba, Argentina, X5006
    - Centro Medico Luquez
  - Esperanza, Santa Fe, Argentina, S3080BQV
    - Sanatorio Esperanza
  - La Plata, Buenos Aires, Argentina, B1904
    - Centro Medico Capital
  - Rosario, Argentina, S2000PBJ
    - CAICI
  - Salta, Argentina, 4400
    - Centro Cardiovascular Salta
  - San Miguel de Tucumán, Argentina, T4000IAP
    - Instituto de Investigaciones de Patologías Respiratorias
  - San Miguel de Tucumán, Argentina, T4000
    - CMC Cardiología Sociedad Simple
  - San Nicolás, Argentina, B2900
    - Instituto de Investigaciones Clinicas San Nicolas
  - Santa Fe, Argentina, 3000
    - Centro de Investigaciones Clínicas del Litoral
  - Santa Fe, Argentina, S3000FSO
    - CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
  - Santa Fe, Argentina, S2152BOF
    - Centro de Investigaciones Clinica Baigorria
  - Santa Rosa, La Pampa, Argentina, L6304BWE
    - MIT Medicina, Investigación y tratamiento
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1440CFD
    - CEMEDIC
  - City of Buenos Aires, Buenos Aires, Argentina, C1425
    - Cardiologia Palermo
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1129ABO
    - CardiaMet
  - Lanús Este, Buenos Aires, Argentina, B1824KAJ
    - Centro Médico CIMEL
  - Pilar, Buenos Aires, Argentina, 1663
    - Hospital Universitario Austral - Instituto de Cardiologia
- Mendoza Province
  - Godoy Cruz, Mendoza, Mendoza Province, Argentina, 5501
    - Hospital Español de Mendoza
- Santa Fe Province
  - Rosario, Santa Fe Province, Argentina, S2000CUD
    - Instituto de Investigaciones Clinicas Rosario
  - Rosario, Santa Fe Province, Argentina, 2000
    - INECO Neurociencias Oroño
  - Rosario, Santa Fe Province, Argentina, 2000
    - Instituto Especialidades de la Salud Rosario
Australia
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australia, 2605
    - Canberra Hospital
- New South Wales
  - Liverpool, New South Wales, Australia, 2170
    - Sydney Cardiometabolic Centre
- Queensland
  - Brisbane, Queensland, Australia, 4032
    - The Prince Charles Hospital
  - Chelmer, Queensland, Australia, 4068
    - Heart of Australia
  - Ipswich, Queensland, Australia, 4305
    - Life Clinical Research
  - Milton, Queensland, Australia, 4064
    - Core Research Group
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Nightingale Research
  - Bedford Park, South Australia, Australia, 5042
    - Flinders Medical Centre
  - Elizabeth Vale, South Australia, Australia, 5112
    - Lyell McEwin Hospital
  - Leabrook, South Australia, Australia, 5068
    - Advara HeartCare Leabrook
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Royal Hobart Hospital - Cardiology Department
- Victoria
  - Frankston, Victoria, Australia, 3199
    - Nightingale Research Victoria
  - Geelong, Victoria, Australia, 3220
    - Adrian Costa Clinical Trials Centre
  - Hoppers Crossing, Victoria, Australia, 3029
    - HeartWest Cardiology - Hoppers Crossing
  - Mulgrave, Victoria, Australia, 3170
    - Advara HeartCare Mulgrave
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - Advara HeartCare Joondalup
Brazil
- - Aracaju, Brazil, 49055-530
    - jmf Clinica do Coracao ltda
  - Goiânia/GO, Brazil, 74605-020
    - Hospital de Clínicas da Universidade Federal de Goiânia
  - Marília/SP, Brazil, 17515-000
    - ICM - Instituto do Coracao de Marilia
  - Sao Jose Rio Preto, Brazil, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
  - São Paulo, Brazil, 01327-001
    - Hospital Alemao Oswaldo Cruz
- Acre
  - Rio Branco, Acre, Brazil, 69915-030
    - Centro de Pesquisa Silvestre Santé
- Alagoa
  - Maceió, Alagoa, Brazil, 57051-500
    - Centro de Pesquisas Clínicas Dr. Marco Mota LTDA
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-320
    - CCIH-Consultoria em Controle de Infecção Hospitalar Ltda
  - Uberlândia, Minas Gerais, Brazil, 38400-500
    - Eurolatino Medical Research Center
- Pernambuco
  - Recife, Pernambuco, Brazil, 50720-110
    - IAPES Pesquisa Clínica - Rede AME Saúde
- Rio Grande do Sul
  - Porto Alegre, Rio Grande do Sul, Brazil, 90410000
    - Hospital de Clinicas de Porto Alegre
- Santa Catarina
  - Blumenau, Santa Catarina, Brazil, 89020-430
    - AngioCor Blumenau
- São Paulo
  - Bragança Paulista, São Paulo, Brazil, 12916-542
    - Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
  - Campinas, São Paulo, Brazil, 13060-080
    - Instituto de Pesquisa Clinica de Campinas
  - Campinas, São Paulo, Brazil, 13060-803
    - PUCCAMP - Hospital e Maternidade Celso Pierro
  - Campinas, São Paulo, Brazil, 13.087-567
    - Synvia Laboratorios E Toxicologia Ltda
  - Ribeirão Preto, São Paulo, Brazil, 14026-900
    - CAPED - Centro Avançado de Pesquisa, Estudos e Diagnósticos
  - São Caetano Do Sul / SP, São Paulo, Brazil, 09521-160
    - Universidade Municipal de São Caetano do Sul (USCS)
  - São José dos Campos, São Paulo, Brazil, 12230-001
    - CIPES - Centro Internacional de Pesquisa Clínica LTDA
  - São Paulo, São Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clínica Ltda
  - São Paulo, São Paulo, Brazil, 05403-000
    - Instituto do Coracao - HCFMUSP
  - São Paulo, São Paulo, Brazil, 04012-909
    - Instituto Dante Pazzanese de Cardiologia
  - São Paulo, São Paulo, Brazil, 04004-030
    - Associacao Beneficente Siria - HCOR
  - Tatuí, São Paulo, Brazil, 18270-170
    - Instituto de Moléstias Cardiovasculares de Tatuí Ltda
Bulgaria
- - Burgas, Bulgaria, 8000
    - Medical center Medconsult Burgas OOD
  - Burgas, Bulgaria, 8000
    - MHAT Heart and Brain EAD - Burgas, Cardiology
  - Dimitrovgrad, Bulgaria, 6400
    - MC Diamedical - 2013 OOD, Dimitrovgrad
  - Dobrich, Bulgaria, 9300
    - MHAT - Dobrich AD, Cardiology
  - Gotse Delchev, Bulgaria, 2900
    - MHAT - Ivan Skenderov EOOD
  - Kozloduy, Bulgaria, 3320
    - Medical centre Zdrave 1 OOD
  - Lom, Bulgaria, 3600
    - DCC 1 - Lom EOOD
  - Montana, Bulgaria, 3400
    - MHAT - City Clinic - Sveti Georgi EOOD
  - Pleven, Bulgaria, 5800
    - Medical center Medconsult Pleven OOD
  - Pleven, Bulgaria, 5800
    - UMHAT - Dr. Georgi Stranski EAD
  - Pleven, Bulgaria, 5804
    - MHAT Heart and Brain EAD - Pleven, Cardiology
  - Pleven, Bulgaria, 5800
    - AIPSCMC - Dr. Nikolay Iliev EOOD
  - Plovdiv, Bulgaria, 4002
    - UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
  - Plovdiv, Bulgaria, 4004
    - AIPSMCIDC - Dr. Georgi Nedyalkov EOOD
  - Sofia, Bulgaria, 1680
    - DCC Convex EOOD
  - Sofia, Bulgaria, 1680
    - Medical center Kalimat EOOD
  - Sofia, Bulgaria, 1431
    - DCC Aleksandrovska EOOD
  - Sofia, Bulgaria, 1527
    - Medical center ISUL - Tsaritsa Yoanna EOOD
  - Sofia, Bulgaria, 1404
    - MHAT Sveta Sofia EOOD
  - Sofia, Bulgaria, 1797
    - UMHAT Sofiamed EAD
  - Sofia, Bulgaria, 1618
    - MC Diamedical - 2013 OOD, Sofia
  - Sofia, Bulgaria, 1415
    - Acibadem City Clinic UMHAT EOOD, Cardiology
  - Sofia, Bulgaria, 1510
    - MC Hera EOOD - Sofia
  - Sofia, Bulgaria, 1000
    - OCIPSMCC - Dr. Aleksandar Nosikov
  - Sofia, Bulgaria, 1142
    - Medical Center Cardiohelp EOOD, Cardiology Consulting room
  - Sofia, Bulgaria, 1431
    - UMHAT Aleksandrovska EAD, Clinic of Cardiology
  - Sofia, Bulgaria, 1606
    - UMHATEM N.I. Pirogov EAD, Cardiology department
  - Sofia, Bulgaria, 4000
    - UMHAT - EUROHOSPITAL PLOVDIV OOD, Department of Internal Diseases
  - Stara Zagora, Bulgaria, 6000
    - MBAL Trakia EOOD
  - Stara Zagora, Bulgaria, 6001
    - Medical Center Nov Rehabilitatsionen center EOOD
  - Varna, Bulgaria, 9010
    - UMHAT Sveta Marina EAD, Second Clinic of Cardiology
  - Varna, Bulgaria, 9009
    - SHATC - Cardiolife OOD - Varna
  - Veliko Tarnovo, Bulgaria, 5006
    - MC Nevromedics EOOD, Cardiology
  - Veliko Tarnovo, Bulgaria, 5006
    - Medical Center Medica Plus Ltd.
Canada
- - Québec, Canada, G1V 4G5
    - Institut universitaire de cardiologie
  - Québec, Canada, G1R2J6
    - CHU de Quebec-Uni Laval-Hotel
- Alberta
  - Calgary, Alberta, Canada, T2N 4Z6
    - University of Calgary
- British Columbia
  - Vancouver, British Columbia, Canada, V6Z1Y6
    - St Pauls Hospital
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - St. Boniface Hospital
- New Brunswick
  - Moncton, New Brunswick, Canada, E1G 1A7
    - G.A. Research Associates Ltd.
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Nova Scotia Health
- Ontario
  - Burlington, Ontario, Canada, L8P 2N4
    - Circulate Cardiac and Vascular Centre
  - Courtice, Ontario, Canada, L1E 2J5
    - Med Trust Research, Inc.
  - Hamilton, Ontario, Canada, L8L 0A9
    - Curnew Medicine Professional Corporation
  - Hamilton, Ontario, Canada, L8W 3K5
    - Cardio Health Clinical Trials
  - Kingston, Ontario, Canada, K7L 2V7
    - Kingston General Hospital
  - North York, Ontario, Canada, M6B 3H7
    - North York Diagn & Cardiac Ctr
  - Oakville, Ontario, Canada, L6M 0L8
    - Halton Healthcare
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Scarborough Village, Ontario, Canada, M1B 5N1
    - Corcare Cardiovascular Research
  - Toronto, Ontario, Canada, M6G 1M2
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M5S 1B1
    - Women's College Hospital
  - Toronto, Ontario, Canada, M6N1B5
    - St. Joseph's Heath Centre
  - Waterloo, Ontario, Canada, N2T 0C1
    - CPS Research
  - Winchester, Ontario, Canada, K0C 2K0
    - Winchester Dist Memorial Hosp
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 5H6
    - CIUSSS du Saguenay-Lac-St-Jean
  - Montreal, Quebec, Canada, H2X 0C1
    - CHUM-Hosp de Univ Montreal
  - Rimouski, Quebec, Canada, G5L5T1
    - CISSS BAS ST-LAURENT, HOPITAL regional DE RIMOUSKI
  - Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
    - C.I.C. Joliette
  - Sherbrooke, Quebec, Canada, J1E 0N8
    - Diex Recherche Sherbrooke
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Diex Recherche Trois-Rivieres
China
- Guangdong
  - Guangzhou, Guangdong, China, 510080
    - Guangdong Provincial People's Hospital-Cardiovascular
  - Guangzhou, Guangdong, China, 510630
    - The First Affiliated Hospital of Jinan University-Cardiovascular
- Hebei
  - Shijiazhuang, Hebei, China, 050023
    - The First Hospital of Hebei Medical University-Cardiovascular
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - The First Affiliated Hospital of Harbin Medical University-Cardiovascular
- Hunan
  - Changsha, Hunan, China, 410004
    - Changsha Central Hospital-Cardiovascular Medicine
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 014040
    - Baotou City Central Hospital-Cardiology
- Jiangsu
  - Changzhou, Jiangsu, China, 213003
    - Changzhou No.2 People's Hospital-Cardiology
  - Changzhou, Jiangsu, China, 213004
    - The First People's Hospital of Changzhou-Cardiology
  - Nanjing, Jiangsu, China, 211100
    - Nanjing Jiangning Hospital-Cardiovascular
  - Suzhou, Jiangsu, China, 215006
    - The First Affiliated Hospital of Soochow University-Cardiology
  - Xuzhou, Jiangsu, China, 221002
    - The Affiliated Hospital of Xuzhou Medical University-Cardiology
- Jilin
  - Changchun, Jilin, China, 130033
    - China-Japan Union Hospital of Jilin University-Cardiology
  - Siping, Jilin, China, 136000
    - Siping Central People's Hospital-Cardiology
- Liaoning
  - Shenyang, Liaoning, China, 110016
    - The People's Hospital of Liaoning Province-Cardiology
- Shaanxi
  - Xi'an, Shaanxi, China, 710068
    - Shaanxi Provincial People's Hospital-Cardiology
- Shandong
  - Jinan, Shandong, China, 250013
    - Jinan Central Hospital-Cardiovascular
  - Jining, Shandong, China, 272029
    - The Affiliated Hospital of Jining Medical University-Cardiology
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, China, 200032
    - Zhongshan Hospital, Fudan University-Cardiology
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, China, 300121
    - Tianjin People's Hospital-Cardiology
- Wuhan
  - Wuhan, Wuhan, China, 430000
    - The Third People's Hospital of Hubei Province (Qiaokou Campus)-Cardiology
Czechia
- - Benešov, Czechia, 256 01
    - Innera s.r.o.
  - Brandýs nad Labem, Czechia, 250 01
    - Medicus Services s.r.o.
  - Brno, Czechia, 625 00
    - Fakultní nemocnice Brno
  - Brno, Czechia, 612 00
    - Kardiologicka ambulance Brno s.r.o.
  - Brno, Czechia, 602 00
    - Kardiologie MUDr. Libor Nechvátal s.r.o.
  - Brno, Czechia, 602 00
    - Fakultni nemocnice u sv. Anny v Brne
  - Brno, Czechia, 602 0
    - CC LIFE s.r.o.
  - Brno - Sever, Czechia, 638 00
    - Kardio Elbl s.r.o.
  - Broumov, Czechia, 550 01
    - Edumed s.r.o.
  - Dolní Břežany, Czechia, 25241
    - Aesculap Ambulance s.r.o.
  - Jihlava, Czechia, 586 33
    - Nemocnice Jihlava, p.o.
  - Mladá Boleslav, Czechia, 293 01
    - Klinika Dr. Pírka s.r.o.
  - Náchod, Czechia, 547 01
    - Edumed s.r.o.
  - Olomouc, Czechia, 779 00
    - Fakultni nemocnice Olomouc
  - Prague, Czechia, 140 00
    - Institut klinicke a experimentalni mediciny
  - Prague, Czechia, 10100
    - Kardiologie a Angiologie Praha s.r.o.
  - Prague, Czechia, 130 00
    - Pratia Prague, s.r.o
  - Zlín, Czechia, 76001
    - Cardio Research s.r.o.
  - Ústí nad Labem, Czechia, 400 01
    - Kardiologie - Ústí nad Labem s.r.o.
  - Česká Třebová, Czechia, 560 02
    - SPIMED, s.r.o.
Denmark
- - Aabenraa, Denmark, 6200
    - Sygehus Sønderjylland, Aabenraa - Afdeling for Hjertesygdomme
  - Frederiksberg, Denmark, 2000
    - Frederiksberg Hospital - Hjertemedicinsk afdeling Y
  - Herlev, Denmark, 2730
    - Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1
  - Hjørring, Denmark, 9800
    - Regionshospital Nordjylland, Hjørring - Afdelingen for hjerte- og hormonsygdomme
  - Holbæk, Denmark, 4300
    - Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
  - Hvidovre, Denmark, 2650
    - Hvidovre Hospital Hjertemedicinsk
  - København Ø, Denmark, 2100
    - Rigshospitalet - Kardiologisk Forskningsenhed
  - Svendborg, Denmark, 5700
    - Svendborg Sygehus - Kardiologisk
  - Viborg, Denmark, 8800
    - Viborg Sygehus
France
- - Bayonne, France, 64100
    - CCECB _Cabinet de Cardiologie ALDAPA
  - Bordeaux, France, 33074
    - Clinique Saint Augustin
  - Brest, France, 29200
    - CHRU BREST - HOPITAL DE LA CAVALE BLANCHE_Service de cardiologie
  - Cholet, France, 49300
    - CENTRE HOSPITALIER DE CHOLET_Service de Cardiologie
  - La Rochelle, France, 17019
    - CH LA ROCHELLE - Service de Cardiologie
  - Le Chesnay, France, 78150
    - CENTRE HOSPITALIER DE VERSAILLES-HOPITAL ANDRE MIGNOT_Service de Cardiologie
  - Le Coudray, France, 28630
    - LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service de Cardiologie
  - Le Kremlin-Bicêtre, France, 94270
    - APHP - HOPITAL BICETRE_Service de Cardiologie
  - Montpellier, France, 34000
    - CLINIQUE DU MILLENAIRE_Service de Cardiologie Interventionelle
  - Nîmes, France, 30000
    - CHU NIMES - HOPITAL CAREMEAU_Service de Cardiologie
  - Pierre-Bénite, France, 69310
    - HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition
  - Saint-Herblain, France, 44800
    - CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition
  - Toulon, France, 83100
    - CHI TOULON - HOPITAL SAINTE MUSSE_Service de Cardiologie
  - Tours, France, 37044
    - CHRU TOURS - HOPITAL TROUSSEAU - Service de Cardiologie
  - Vandœuvre-lès-Nancy, France, 54500
    - CHRU NANCY - HOPITAL BRABOIS_Service de Cardiologie
Germany
- - Aachen, Germany, 52074
    - Uniklinik Aachen - Med. Klinik I
  - Bad Friedrichshall, Germany, 74177
    - SLK-Klinken Heilbronn - Klinikum am Plattenwald Bad Friedrichshall
  - Bad Oeynhausen, Germany, 32545
    - Herz- und Diabeteszentrum NRW - Bad Oeynhausen
  - Berlin, Germany, 13597
    - Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR
  - Berlin, Germany, 13353
    - Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)
  - Berlin, Germany, 10559
    - Kardiologie im Spreebogen
  - Berlin, Germany, 12157
    - Policum Berlin Studien GmbH - Friedenau
  - Berlin, Germany, 13405
    - KARDIA - Dr. Hashemi
  - Bochum, Germany, 44791
    - Kath. Klinikum Bochum gGmbH - St. Josef-Hospital Kardiologie
  - Coburg, Germany, 96450
    - Sana Kliniken Oberfranken Coburg GmbH - II. Med. Klinik, Kardiologie
  - Cologne, Germany, 50678
    - Augustinerinnen KHs - Cellitinnen KH Köln
  - Cologne, Germany, 51065
    - Praxis für Innere Medizin, Kardiologie, Pneumologie - Köln
  - Dresden, Germany, 01307
    - Uniklinik TU Dresden - Herzzentrum Dresden GmbH
  - Dresden, Germany, 01277
    - Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
  - Dresden, Germany, 01099
    - Facharztzentrum Dresden Betriebsgesellschaft mbH
  - Elsterwerda, Germany, 04910
    - Zentrum fuer Klinische Studien Suedbrandenburg GmbH
  - Erfurt, Germany, 99097
    - Kath. Hospitalvereinigung Thüringen gGmbH - KKH St. Johann Nepomuk - Innere Med. II
  - Essen, Germany, 45355
    - Gemeinschaftspraxis Faghih-Friedrichs-Zühlke
  - Essen, Germany, 45355
    - Medizentrum Essen-Borbeck
  - Frankfurt, Germany, 60389
    - MVZ CCB Frankfurt und Main-Taunus GbR
  - Frankfurt am Main, Germany, 60596
    - Universitätsklinikum Frankfurt aM - Kardiologie
  - Freiburg im Breisgau, Germany, 79106
    - Universitätsklinikum Freiburg - Medical Center
  - Fulda, Germany, 36037
    - MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien
  - Hamburg, Germany, 22041
    - cardiologicum Hamburg - Studienzentrum
  - Kaiserslautern, Germany, 67655
    - Kardiopraxis Schirmer
  - Kamp-Lintfort, Germany, 47475
    - Praxis Joachim Heisters
  - Kiel, Germany, 24105
    - Uniklinik Schleswig-Holstein - Med. Klinik III Kardiologie und Internist. Intensivmedizin
  - Langen, Germany, 63225
    - Asklepios Klinik Langen - Medizinische Klinik I
  - Ludwigshafen am Rhein, Germany, 67071
    - Kardiologische Praxis Ludwigshafen
  - Mainz, Germany, 55131
    - Marienhaus Klinikum Mainz GmbH - Innere Medizin I
  - Mainz, Germany, 55116
    - Gesundheitscentrum Mainz (Regner / Schmitt)
  - Markkleeberg, Germany, 04416
    - Praxis Dr. med. Jens Taggeselle
  - Münster, Germany, 48149
    - Universitätsklinikum Münster - Klinik für Kardiologie I
  - Neuruppin, Germany, 16816
    - Ruppiner Kliniken - Universitätsklinikum Ruppin-Brandenburg
  - Osnabrück, Germany, 49074
    - Niels-Stensen-Kliniken Marienhospital Osnabrück - Klinik für Innere Medizin, Kardiologie und Intensivmedizin
  - Papenburg, Germany, 26871
    - Kardiologische Gemeinschaftspraxis Papenburg
  - Rostock, Germany, 18059
    - CardioConsil GmbH
  - Rotenburg A. D. Fulda, Germany, 36199
    - Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg GmbH - Zentrum für Klinische Forschung
  - Stuhr, Germany, 28816
    - Gemeinschaftspraxis Melcherstätte - Dr. L. Pohlmeier, T. Drescher
  - Stuttgart, Germany, 70376
    - Robert-Bosch-Krankenhaus Stuttgart - Behandlungsexzellenz Bosch Health Campus
  - Traunstein, Germany, 83278
    - Kliniken Südostbayern AG - Klinikum Traunstein
  - Villingen-Schwenningen, Germany, 78052
    - Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH
  - Wermsdorf, Germany, 04779
    - Al-Zoebi
  - Weyhe, Germany, 28844
    - Herz-Lungen-Zentrum Weyhe-Leeste
  - Witten, Germany, 58455
    - Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
  - Würzburg, Germany, 97078
    - Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz
Greece
- - Ampelokipoi/Athens, Greece, 11522
    - General Hospital of Athens "Elpis" - Cardiology Department
  - Athens, Greece, 11528
    - Alexandra General Hospital, Therapeutic Clinic
  - Athens, Greece, 14233
    - Konstantopouleio G.H. of Athens, "Agia Olga"
  - Athens, Greece, 15123
    - "Hygeia" General Hospital of Athens
  - Athens, Greece, 11527
    - Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
  - Athens, Greece, 115 25
    - 251 Air Force General Hospital - Department of Endocrinology & Diabetes
  - Athens, Greece, 11527
    - 'G. Gennimatas' General Hospital of Athens - Cardiology Department
  - Athens, Greece, 151 25
    - Athens Medical Center S.A (Iatriko Athinon) - Cardiology Clinic
  - Athens, Greece, 151 27
    - Sismanogleio General Hospital - Amalia Fleming Hospital, Cardiology Department
  - Athens, Greece, 15562
    - Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic
  - Athens/Voula, Greece, 16673
    - Asklepieion General Hospital - Cardiology Clinic
  - Chaidari, Athens, Greece, 12462
    - U.G.H of Athens "Attikon"
  - Chalcis, Greece, 34100
    - General Hospital of Chalkida - Cardiology department
  - Chios, Greece, 82100
    - General Hospital of Chios "Skilitsio" - Cardiology Clinic
  - Goudi/Athens, Greece, 115 27
    - General Hospital of Athens "Laiko"
  - Heraklion, Greece, 71409
    - General Hospital Venizeleio-Pananeio - Cardiology department
  - Kalamata, Greece, 24100
    - General Hospital of Kalamata - Cardiology Department
  - Larissa, Greece, 410 00
    - Iaso Thessalia General Clinic Private Obstetrics S.A. - Cardiology Clinic
  - Larissa/Thessaly, Greece, 41110
    - Univ Gen Hospital Larisa, Cardiology Medicine Clinic
  - Peristeri, Greece, 121 31
    - Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
  - Thessaloniki, Greece, 54636
    - "AHEPA" University General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54642
    - 'Ippokrateio' General Hospital of Thessaloniki
  - Thessaloniki, Greece, 54636
    - AHEPA General University Hospital
  - Thessaloniki, Greece, 57010
    - General Hospital of Thessaloniki "G.Papanikolaou"
  - Thessaloniki, Greece, 546 39
    - Athens Medical Center S.A., European Interbalkan Medical Center - Department of Internal Medicine
India
- - New Delhi, India, 110060
    - Sir Ganga Ram Hospital
  - New Delhi, India, 110029
    - All India Institute of Medical Sciences (AIIMS)
  - New Delhi, India, 110065
    - National Heart Institute,India
  - Pune, India, 411028.
    - WMF's Villoo Poonawalla Memorial Hospital
- Andhra Pradesh
  - Guntur, Andhra Pradesh, India, 522001
    - Endolife Specialty Hospitals
  - Vijaywada, Andhra Pradesh, India, 520008
    - Government Siddhartha Medical College & Government General Hospital, Vijayawada
- Chhattisgarh
  - Raipur, Chhattisgarh, India, 492007
    - SMC Heart Institute and IVF Research Centre
- Gujarat
  - Vadodara, Gujarat, India, 390022
    - Rhythm Heart Institute
- Haryana
  - Gurgaon, Haryana, India, 122001
    - Medanta - The Medicity Multi-Speciality Hospital, Gurugram
  - Gurugram, Haryana, India, 122003
    - Fortis Memorial Research Institute _Gurgaon
- Karnataka
  - Bangalore, Karnataka, India, 560092
    - Life Care Hospital and Research Centre
  - Belagavi, Karnataka, India, 590010
    - KLES Dr. Prabhakar Kore Hospital & Medical Research Centre
  - Hubbali, Karnataka, India, 580022
    - Karnataka Medical College and Research Institute
  - Mysuru, Karnataka, India, 570004
    - JSS Hospital, Mysore
- Kerala
  - Kochi, Kerala, India, 682027
    - Aster Medcity
  - Kochi, Kerala, India, 682041
    - Amrita Institute of Medical Sciences
  - Kochi, Kerala, India, 682018
    - Lisie Hospital
- Madhya Pradesh
  - Indore, Madhya Pradesh, India, 452007
    - Mohak Bariatrics and Robotics
- Maharashtra
  - Karad, Maharashtra, India, 415539
    - Krishna Vishwa Vidyapeeth
  - Mumbai, Maharashtra, India, 400012
    - Seth GS Medical College & KEM Hospital
  - Nagpur, Maharashtra, India, 440010
    - Arneja Heart & Multispeciality Hospital
  - Nagpur, Maharashtra, India, 441108
    - All India Institute of Medical Sciences (AIIMS), Nagpur
  - Nagpur, Maharashtra, India, 440033
    - Sengupta Hospital and Research Institute
  - Nagpur, Maharashtra, India, 440012
    - Crescent Hospital And Heart Centre
  - Nagpur, Maharashtra, India, 440019
    - Nkpsims & Rc , Lata Mangeshkar Hospital , Hingna
  - Nashik, Maharashtra, India, 422005
    - Vijan Hospital & Research Centre
  - Pune, Maharashtra, India, 411004
    - Deenanath Mangeshkar Hospital & Research Centre
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, India, 110002
    - G B Pant Institute of Postgraduate Medical Education and Research
  - New Delhi, National Capital Territory of Delhi, India, 110062
    - Batra Hospital and Medical Research Center
- New Delhi
  - New Dehli, New Delhi, India, 110029
    - VMMC & Safdarjung Hospital
- Odisha
  - Bhubaneswar, Odisha, India, 751019
    - All India Institute of Medical Sciences (AIIMS), Bhubaneswar
- Punjab
  - Ludhiana, Punjab, India, 141001
    - Dayanand Medical College & Hospital
  - Mohali, Punjab, India, 160062
    - Fortis Hospital, Mohali
- Tamil Nadu
  - Chennai, Tamil Nadu, India, 600116
    - Sri Ramachandra Medical Centre
  - Coimbatore, Tamil Nadu, India, 641018
    - KG Hospital and PG Medical Institute & Research Centre
- Telangana
  - Hyderabad, Telangana, India, 500012
    - Osmania General Hospital
  - Hyderabad, Telangana, India, 500055
    - Malla Reddy Narayana Multispeciality Hospital
- Uttar Pradesh
  - Aligarh, Uttar Pradesh, India, 202002
    - Jawaharlal Nehru Medical College and Hospital
  - Kanpur, Uttar Pradesh, India, 208002
    - Lps Institute of Cardiology, Gsvm Medical College
  - Lucknow, Uttar Pradesh, India, 226014
    - Sanjay Gandhi Postgraduate Institute of Medical Sciences
  - Lucknow, Uttar Pradesh, India, 226003
    - King George's Medical University (KGMU)
  - Varanasi, Uttar Pradesh, India, 221010
    - Galaxy Life Care Services Pvt. Ltd
- Uttarakhand
  - Dehradun, Uttarakhand, India, 248001
    - Shri Mahant Indiresh Hospital
  - Udham Singh Nagar, Uttarakhand, India, 263153
    - The Medicity Super Speciality Hospital,
- West Bengal
  - Durgapur, West Bengal, India, 713216
    - HealthWorld Hospitals
Israel
- - Afula, Israel, 1834111
    - Haemek MC - Research Unit of Internal Medicine C
  - Ashdod, Israel, 7747629
    - Assuta Ashdod - The Institute of Cardiology
  - Beer Yaakov, Israel, 7033001
    - Shamir MC - Pediatric and Adolescents Endocrinology unit
  - Beersheba, Israel, 84101
    - Soroka MC - Department of Cardiology
  - Hadera, Israel, 3810101
    - Hillel Yaffe MC - Cardiology Department
  - Haifa, Israel, 3109601
    - Rambam MC - Heart Failure Unit
  - Haifa, Israel, 3525428
    - Bnai Zion MC - Department of Cardiology
  - Holon, Israel, 5840511
    - Clalit HMO Holon - Heart Institute
  - Jerusalem, Israel, 91120
    - Hadassah Ein Karam MC - Cardio Department
  - Safed, Israel, 13100
    - Ziv MC - Cardiology Department
Italy
- - Sassari, Italy, 7100
    - AOU Sassari - UOC Cardiologica Clinica ed Interventistica
- Abruzzo
  - Chieti, Abruzzo, Italy, 66100
    - Ospedale SS. Annunziata di Chieti - U.O. Clinica medica Medicina generale 1
- Calabria
  - Cosenza, Calabria, Italy, 87100
    - Ospedale Santissima Annunziata - Dipartimento Cardio Toraco Vascolare
- Campania
  - Naples, Campania, Italy, 80131
    - AOU Federico II Di Napoli - DAI di Medicina Interna e della Complessità Clinica
- Emilia-Romagna
  - Bentivoglio, Emilia-Romagna, Italy, 40010
    - Ospedale di Bentivoglio - UOC Cardiologia
  - Bologna, Emilia-Romagna, Italy, 40138
    - IRCCS Sant'Orsola Malpighi - Dip. Malattie Cardio-Toraco-Vascolare
  - Bologna, Emilia-Romagna, Italy, 40139
    - Ospedale Bellaria Carlo Alberto Pizzardi - UO Cardiologia e Unità coronarica
  - Ferrara, Emilia-Romagna, Italy, 44124
    - Arcispedale Sant'Anna (Cona) - Dipartimento Interaziendale Cardio-toraco-vascolare
  - Reggio Emilia, Emilia-Romagna, Italy, 42123
    - Arcispedale S. Maria Nuova - U.O.C. Cardiologia
- Friuli Venezia Giulia
  - Udine, Friuli Venezia Giulia, Italy, 33100
    - Ospedale S. Maria della Misericordia - Clinica Medica Udine
- Lazio
  - Latina, Lazio, Italy, 04100
    - ICOT Istituto Marco Pasquali - UOC Cardiologia
  - Rome, Lazio, Italy, 00128
    - Pol. Uni. Campus Biomedico - UOC Cardiologia
  - Rome, Lazio, Italy, 00133
    - Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOC Cardiologia
  - Rome, Lazio, Italy, 00163
    - IRCCS San Raffaele - Dipartimento area Cardiorespiratoria
  - Rome, Lazio, Italy, 00168
    - Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Scienze Cardiovascolari
  - Rome, Lazio, Italy, 00189
    - Azienda Ospedaliero - Universitaria Sant'Andrea - UOC Medicina interna
- Liguria
  - Genoa, Liguria, Italy, 16132
    - IRCCS Ospedale Policlinico San Martino - U.O. Clinica di Malattie dell'Apparato Cardiovascolare e UTIC
- Lombardy
  - Bergamo, Lombardy, Italy, 24127
    - ASST Papa Giovanni XXIII - Cardiologia 1
  - Brescia, Lombardy, Italy, 25123
    - Spedali Civili Brescia - U.O. Medicina Generale 2
  - Cremona, Lombardy, Italy, 26100
    - Ospedale Cremona - U.O. Cardiologia
  - Milan, Lombardy, Italy, 20132
    - Ospedale San Raffaele S.r.l. - Unità Clinica Anestesia, Rianimazione e Terapia Intensiva Cardio-Toraco-Vascolare
  - Pavia, Lombardy, Italy, 27100
    - IRCCS Policlinico San Matteo - S.C. Cardiologia
  - San Donato Milanese, Lombardy, Italy, 20097
    - Policlinico San Donato di Milano S.p.A - UO Cardiologia Universitaria Perioperatoria e Riabilitativa
  - Varese, Lombardy, Italy, 21100
    - ASSL Sette Laghi - Ospedale Galmarini di Tradate
- Milano
  - Rozzano, Milano, Italy, 20089
    - IRCCS Humanitas - UOC Cardiologia
- Sicily
  - Messina, Sicily, Italy, 98124
    - DAI Scienze Mediche - UOC Medicina Interna Angiologia e Malattie Aterosclerotiche
  - Palermo, Sicily, Italy, 90127
    - Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - U.O. Cardiologia
- Tuscany
  - Grosseto, Tuscany, Italy, 58100
    - Ospedale Misericordia Grosseto - UOC Cardiologia
  - Pisa, Tuscany, Italy, 56126
    - Azienda Ospedaliero Universitaria Pisana - U.O. Medicina 1
  - Siena, Tuscany, Italy, 53100
    - Azienda Ospedaliero-Universitaria Senese - Dipartimento Cardio-toraco-vascolare
- Umbria
  - Perugia, Umbria, Italy, 06129
    - AOU Perugia - Santa Maria della Misericordia - S. C. Medicina Interna
- Veneto
  - Padova, Veneto, Italy, 35128
    - Azienda Ospedaliera Padova - UOC Clinica Medica 3
  - Treviso, Veneto, Italy, 31100
    - Ospedale Ca' Foncello - U.O.C. Medicina Generale 1
Japan
- - Bunkyo-ku, Tokyo, Japan, 113-8603
    - NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine
  - Chiba-shi,Chiba, Japan, 260-8606
    - National Hospital Organization Chiba Medical Center_Cardiovascular Medicine
  - Chikushino-shi, Fukuoka, Japan, 818-8516
    - Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
  - Fuchu-shi,Tokyo, Japan, 183-0003
    - SAKAKIBARA HEART INSTITUTE_Cardiology
  - Fukuoka-shi, Fukuoka, Japan, 811-0213
    - Fukuoka Wajiro Hospital_Cardiology
  - Higashiosaka-shi, Osaka, Japan, 578-8588
    - Higashiosaka City Medical Center_Cardiovascular Medicine
  - Himeji-shi, Hyogo, Japan, 670-8560
    - Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
  - Ibaraki, Japan, 300-0028
    - Tsuchiura Kyodo General Hospital_Internal Medicine
  - Ibaraki, Japan, 311-3193
    - National Hospital Organization Mito Medical Center_Cardiovascular medicine
  - Kanagawa, Japan, 232-0024
    - Yokohama City University Medical Center_Cardiovascular Center
  - Kasugai-shi, Aichi, Japan, 486-8510
    - Kasugai Municipal Hospital_Cardiovascular Medicine
  - Kofu-shi, Yamanashi, Japan, 400-8506
    - Yamanashi Prefectural Central Hospital_Cardiology
  - Kyoto-shi, Kyoto, Japan, 612-8555
    - National Hospital Organization Kyoto Medical Center_Cardiology
  - Matsumoto-shi, Nagano, Japan, 390-8621
    - Shinshu University Hospital__Department of Cardiology
  - Miura-gun, Kanagawa, Japan, 240-0116
    - Hayama Heart Center_Cardiology
  - Nagasaki, Japan, 850-8555
    - Nagasaki Harbor Medical Center_Cardiovascular medicine
  - Osaka, Japan, 558-8558
    - Osaka General Medical Center_Cardiology
  - Osaka-Shi, Osaka, Japan, 545-8586
    - Osaka Metropolitan University Hospital_Cardiovascular Medicine
  - Ota-shi, Gunma, Japan, 373-8585
    - Ota Memorial Hospital_Cardiology
  - Sapporo-shi, Hokkaido, Japan, 006-0852
    - Mita Clinic of Internal Medicine and Cardiology_Cardiology
  - Shinjuku-ku, Tokyo, Japan, 162-8655
    - National Center for Global Health and Medicine_Cardiology
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital_Cardiovascular Medicine
  - Tokyo, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic_Internal Medicine
  - Wakayama-shi, Wakayama, Japan, 640-8558
    - Japanese Red Cross Wakayama Medical Center_Department of Cardiology
  - Yokohama-shi，Kanagawa, Japan, 236-0004
    - Yokohama City University Hospital_Cardiovascular Medicine
- Ehime
  - Uwajima-shi, Ehime, Japan, 798-8510
    - Uwajima City Hospital_Cardiology
Malaysia
- - Kangar, Perlis, Malaysia, 01000
    - Hospital Tuanku Fauziah
  - Kuala Lumpur, Malaysia, 50586
    - Hospital Kuala Lumpur
  - Kuala Lumpur, Malaysia, 50400
    - National Heart Institute
- Johor
  - Johor Bahru, Johor, Malaysia, 80100
    - Hospital Sultanah Aminah
  - Muar town, Johor, Malaysia, 84000
    - Hospital Pakar Sultanah Fatimah
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Hospital Sultanah Bahiyah
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia
- Kuala Lumpur
  - Cheras, Kuala Lumpur, Malaysia, 56000
    - Hospital Canselor Tuanku Muhriz UKM
  - Kuala Lumpur, Kuala Lumpur, Malaysia, 50470
    - Cardiac Vascular Sentral Kuala Lumpur
  - Lembah Pantai, Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
- Pahang
  - Kuantan, Pahang, Malaysia, 25100
    - Hospital Tengku Ampuan Afzan
- Perak
  - Taiping, Perak, Malaysia, 34000
    - Hospital Taiping
- Sarawak
  - Kuching, Sarawak, Malaysia, 93586
    - Sarawak General Hospital
  - Miri, Sarawak, Malaysia, 98000
    - Hospital Miri
- Selangor
  - Kajang, Selangor, Malaysia, 43000
    - Hospital Serdang
  - Sungai Buloh, Selangor, Malaysia, 47000
    - University Technology MARA (UiTM) - Sg Buloh
Mexico
- - Chihuahua City, Mexico, 31203
    - Centro de Investigación Integral MEDIVEST
  - San Luis Potosí City, Mexico, 44340
    - Centro de Atención e Investigación Cardiovascular del Potosi (CICAP)
- Chihuahua
  - Col. Zona Comercial Plaza Del Sol, Chihuahua, Mexico, 31207
    - Scientia Investigación Clínica S. C.
- Coahuila
  - Torreón, Coahuila, Mexico, 27000
    - CIMAB SA de CV
- Guanajuato
  - León, Guanajuato, Mexico, 37530
    - Instituto Cardiovascular de León S.C.
- Hidalgo
  - Actopan, Hidalgo, Mexico, 42500
    - Centro de Atención al Diabético Actopan (CAD)
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44657
    - Consultorio Privado Dr Gabriel Arturo Ramos
  - Guadalajara, Jalisco, Mexico, 44670
    - Consultorio Privado Dr. Francisco Padilla
- Mexico City
  - Col Roma Norte, Mexico City, Mexico, 06700
    - Clinstile S.A. de C.V.
  - Cuauhtémoc, Mexico City, Mexico, 06720
    - Hospital General de México (HGM)
  - Tlalpan, Mexico City, Mexico, 14050
    - Consultorio Dr. Eduardo Chuquiure
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Hospital Universitario Dr. José Eleuterio González_Monterrey
  - Monterrey, Nuevo León, Mexico, 64040
    - Internal Medicine Clin Trials
  - Monterrey, Nuevo León, Mexico, 66278
    - Hospital Zambrano Hellion TecSalud
  - San Nicolás de los Garza, Nuevo León, Mexico, 66465
    - Centro de Investigación y Control Metabólico S. C.
- Oaxaca
  - Oaxaca City, Oaxaca, Mexico, 68000
    - Oaxaca Site Management Organization (OSMO)
- Querétaro
  - Querétaro City, Querétaro, Mexico, 76100
    - Panamerican Clinical Research Mexico S. A de C.V
- Tamaulipas
  - Ciudad Madero, Tamaulipas, Mexico, 89450
    - SIYODE S.A. de C.V. Unimeden
- Veracruz
  - Xalapa, Veracruz, Mexico, 91193
    - Consultorio 1020 Hospital Angeles Xalapa
- Yucatán
  - Mérida, Yucatán, Mexico, 97070
    - Medical Care and Research S. A de C.V
Netherlands
- - 's-Hertogenbosch, Netherlands, 5223 GZ
    - Jeroen Bosch Zkh
  - Amsterdam, Netherlands, 1105 AZ
    - AmsterdamUMC AMC
  - Beverwijk, Netherlands, 1942 LE
    - Rode Kruis Zkh Beverwijk - Cardiologie
  - Breda, Netherlands, 4818 CK
    - Amphia Ziekenhuis
  - Dirksland, Netherlands, 3247 BW
    - Van Weel-Bethesda Zkh - Cardiologie
  - Ede, Netherlands, 6716 RP
    - Gelderse Vallei - Cardiologie
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Zkh Eindhoven - Cardiologie
  - Gouda, Netherlands, 2803HH
    - Groene Hart Zkh Gouda - Cardiologie
  - Groningen, Netherlands, 9713 GZ
    - UMC Groningen - Cardiologie
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Gasthuis Haarlem
  - Heerlen, Netherlands, 6419 PC
    - Zuyderland ziekenhuis - Cardiologie
  - Helmond, Netherlands, 5707 HA
    - Elkerliek Ziekenhuis - Cardiologie
  - Leiderdorp, Netherlands, 2353 GA
    - Alrijne Leiderdorp - Cardiologie
  - Nieuwegein, Netherlands, 3435 CM
    - St. Antonius Zkh Nieuwegein - Cardiologie
  - Roosendaal, Netherlands, 4708 AE
    - Bravis Zkh Roosendaal
  - Rotterdam, Netherlands, 3045 PM
    - Franciscus Gasthuis en Vlietland
  - Rotterdam, Netherlands, 3079 DZ
    - Maasstad Ziekenhuis - Cardiologie
  - Utrecht, Netherlands, 3582 KE
    - Diakonessenhuis Utrecht - Cardiologie
  - Veldhoven, Netherlands, 5504 DB
    - Maxima MC Veldhoven - Cardiologie
  - Venlo, Netherlands, 5912 BL
    - VieCuri - Cardiologie
Poland
- - Bialystok, Poland, 15-276
    - Uniwersytecki Szpital Kliniczny w Bialymstoku
  - Bydgoszcz, Poland, 85-231
    - Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.
  - Bydgoszcz, Poland, 85-092
    - Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk
  - Dąbrowa Górnicza, Poland, 41-300
    - American Heart of Poland S.A.
  - Elblag, Poland, 82-300
    - NZOZ "Twoje Zdrowie EL" Sp. z o.o.
  - Gdynia, Poland, 81-519
    - Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej
  - Grodzisk Mazowiecki, Poland, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
  - Katowice, Poland, 40-648
    - Pro Familia Altera Sp. z o.o.
  - Katowice, Poland, 40-156
    - Clinical Medical Research Sp. z o.o.
  - Katowice, Poland, 40-600
    - Gyncentrum Sp. z o. o.
  - Komorniki, Poland, 62-052
    - Centrum Medyczne Komorniki Sp. z o.o.
  - Krakow, Poland, 31-271
    - UniCardia & UniMedica & UniEstetica
  - Krakow, Poland, 31-826
    - Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
  - Krosno, Poland, 38-400
    - Intercard Spolka z ograniczona odpowiedzialnoscia
  - Kędzierzyn-Koźle, Poland, 47-200
    - American Heart of Poland S.A.
  - Lodz, Poland, 91-002
    - NZOZ SALUSMED Jan Zbigniew Peruga PPHU SALUS
  - Lodz, Poland, 93-513
    - Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika
  - Lowicz, Poland, 99-400
    - Centrum Medyczne Ogrodowa Sp. z o.o.
  - Lublin, Poland, 20-090
    - Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
  - Lublin, Poland, 20-068
    - Michal Tomaszewski Indywidualna Praktyka Lekarska
  - Olsztyn, Poland, 10-165
    - FutureMeds Sp. z o.o.
  - Ostrów Wielkopolski, Poland, 63-400
    - Jantar Sp. z o.o.
  - Przemyśl, Poland, 37-700
    - Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
  - Rzeszów, Poland, 35-111
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie
  - Staszów, Poland, 28-200
    - Velocity Nova Sp. z o.o.
  - Szczecin, Poland, 71-500
    - Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
  - Tarnów, Poland, 33-100
    - Metabolica Sp. z o.o.
  - Warsaw, Poland, 04-628
    - Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
  - Warsaw, Poland, 02-679
    - Medon Clinical Research Sp. z o.o.
  - Wroclaw, Poland, 50-556
    - Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
  - Wroclaw, Poland, 50-981
    - 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
  - Włocławek, Poland, 87-800
    - Kardio Life - Tomasz Borkowski
  - Zabrze, Poland, 41-800
    - Slaskie Centrum Chorob Serca W Zabrzu
  - Zamość, Poland, 22-400
    - Velocity Nova Sp. z o.o.
  - Świnoujście, Poland, 72-600
    - Balticmed Świnoujście Sp. z o. o.
  - Żyrardów, Poland, 96-300
    - Prywatna Praktyka Lekarska Anna Chudoba
- Greater Poland Voivodeship
  - Leszno, Greater Poland Voivodeship, Poland, 64-100
    - Serce Sp. z o.o.
- Lesser Poland Voivodeship
  - Chrzanów, Lesser Poland Voivodeship, Poland, 32-500
    - Centrum Medyczne MBB-MED Marta Blach-Burek
  - Tarnów, Lesser Poland Voivodeship, Poland, 33-100
    - Specjalistyczny Szpital im. E. Szczeklika w Tarnowie
- Lublin Voivodeship
  - Lublin, Lublin Voivodeship, Poland, 20-718
    - Ekamed Sp. z o.o.
- Masovian Voivodeship
  - Płock, Masovian Voivodeship, Poland, 09-407
    - Cbk Med Clinic Sp. z o.o.
- Pomeranian Voivodeship
  - Gdynia, Pomeranian Voivodeship, Poland, 81-157
    - Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
- Silesian Voivodeship
  - Ustroń, Silesian Voivodeship, Poland, 43-450
    - American Heart of Poland S.A.
- West Pomeranian Voivodeship
  - Szczecin, West Pomeranian Voivodeship, Poland, 71-526
    - Osrodek Badan Klinicznych LabMed Sp. z o.o.
- Łódź Voivodeship
  - Lodz, Łódź Voivodeship, Poland, 90-549
    - Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
Puerto Rico
- - San Juan, Puerto Rico, 00918
    - Torre De Plaza Las Americas
South Africa
- - Polokwane, South Africa, 0699
    - Dr Mabowe Makhomisane's Rooms
- Eastern Cape
  - East London, Eastern Cape, South Africa, 5201
    - Synergy Biomed Research Institute
- Free State
  - Bloemfontein, Free State, South Africa, 9301
    - Iatros International
- Gauteng
  - Benoni, Gauteng, South Africa, 1501
    - East Rand Physicians
  - Johannesburg, Gauteng, South Africa, 2193
    - Wits Clinical Research
  - Johannesburg, Gauteng, South Africa, 2013
    - Wits Bara Clinical Trial Site
  - Johannesburg, Gauteng, South Africa, 2157
    - Tickerdoc Research (Pty) LTD
  - Kempton Park, Gauteng, South Africa, 1619
    - Clinresco Centres (Pty) Ltd
  - Midrand, Gauteng, South Africa, 1685
    - Shop#1 Health Emporium
  - Pretoria, Gauteng, South Africa, 0183
    - Jongaie Research
  - Pretoria, Gauteng, South Africa, 0186
    - Clinical Trial Systems (CTC)
  - Pretoria, Gauteng, South Africa, 0157
    - Raslouw Private Hospital
- KwaZulu-Natal
  - Durban, KwaZulu-Natal, South Africa, 4450
    - Dr Pillay's Rooms
  - Durban, KwaZulu-Natal, South Africa, 4001
    - Synapta Clinical Research Centre
  - KwaDukuza, KwaZulu-Natal, South Africa, 4449
    - Clinical Research Institute of South Africa
  - Pietermaritzburg, KwaZulu-Natal, South Africa, 3200
    - Meditrial Clinical Research Centre
- Western Cape
  - Cape Town, Western Cape, South Africa, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, South Africa, 7500
    - Tread Research (Pty)Ltd
  - Cape Town, Western Cape, South Africa, 7560
    - Bella Vita Clinical Research
  - Cape Town, Western Cape, South Africa, 7935
    - Cardiac Clinical Research Unit, University of Cape Town
  - Cape Town, Western Cape, South Africa, 7530
    - InnoMed Clinical Trial Centre
  - Cape Town, Western Cape, South Africa, 7130
    - Helderberg Research Institute
  - Mossel Bay, Western Cape, South Africa, 6500
    - Dr Hendrik Snyman's Practice
  - Somerset West, Western Cape, South Africa, 7130
    - Clinical Trials Network Helderberg
South Korea
- - Daegu, South Korea, 42601
    - Keimyung University Dongsan Hospital
  - Daejeon, South Korea, 35015
    - Chungnam National University Hospital
  - Gangwon-do, South Korea, 26426
    - WonJu Severance Christian Hospital
  - Gwangju, South Korea, 61469
    - Chonnam National University Hospital
  - Incheon, South Korea, 21565
    - Gachon University Gil Medical Center
  - Incheon, South Korea, 22332
    - Inha University Hospital_Cardiology
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05505
    - Asan Medical Center
  - Seoul, South Korea, 06351
    - Samsung Medical Center
  - Seoul, South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 06591
    - The Catholic University of Korea, Seoul St. Mary's Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 08308
    - Korea University Guro Hospital
  - Seoul, South Korea, 04763
    - Hanyang University Seoul Hospital
  - Seoul, South Korea, 06273
    - Gangnam Severance Hospital_Cardiology
  - Suwon, South Korea, 16499
    - Ajou University Hospital
- Gyeonggi-do
  - Anyang-si, Gyeonggi-do, South Korea, 14068
    - Hallym University Sacred Heart Hospital_Cardiology
  - Seongnam-si, Gyeonggi-do, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Uijeongbu-si, Gyeonggi-do, South Korea, 11765
    - The Catholic University of Korea, Uijeongbu ST. Mary's Hospital_Cardiology
- Gyeongsangnam-do
  - Yangsan, Gyeongsangnam-do, South Korea, 50612
    - Pusan National University Yangsan Hospital
Spain
- - A Coruña, Spain, 15006
    - Complejo Hospitalario Universitario A Coruna
  - A Coruña, Spain, 15006
    - Instituto Medico Quirurgico San Rafael
  - Alcorcón, Spain, 28922
    - H. Fundación Alcorcón_Cardiología
  - Antequera, Spain, 29200
    - Hosp. Comarcal de Antequera_Medicina Interna
  - Badalona, Spain, 08916
    - Hospital Germans Trias i Pujol
  - Barcelona, Spain, 08035
    - Hospital Vall d'Hebron
  - Barcelona, Spain, 08041
    - Hospital de la Santa Creu i Sant Pau
  - Bilbao, Spain, 48013
    - Hospital de Basurto
  - El Palmar, Spain, 30120
    - Hospital Univ. Virgen de la Arrixaca
  - Girona, Spain, 17007
    - Hospital Univ. de Gerona Doctor Josep Trueta
  - Granada, Spain, 18014
    - Hospital Universitario Virgen de las Nieves
  - Jaén, Spain, 23007
    - Hosp. Univ. de Jaén_Cardiología
  - Las Palmas de Gran Canaria, Spain, 35010
    - Hosp. U Gran Canaria Dr. Negrín_Cardiologia
  - Lugo, Spain, 27003
    - Hospital Universitario Lucus Augusti
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Madrid, Spain, 28041
    - Hospital 12 de Octubre
  - Madrid, Spain, 28003
    - Hospital Univ. La Luz_Cardiología
  - Madrid, Spain, 28034
    - Hospital Ramón.y Cajal_Med. Interna
  - Majadahonda, Spain, 28222
    - Hospital Universitario Puerta de Hierro Majadahonda
  - Sanlúcar de Barrameda, Spain, 11540
    - H Virgen del Camino_Sanlúcar_Medicina Interna
  - Seville, Spain, 41013
    - Hospital Universitario Virgen del Rocio
  - Seville, Spain, 41014
    - Hospital Universitario Virgen de Valme
  - Valencia, Spain, 46010
    - Hospital Clinico Universitario de Valencia
  - Villamartín, Spain, 11650
    - Hosp. Virgen de las Montañas_Medicina Interna
- Catalonia
  - L'Hospitalet de Llobregat, Catalonia, Spain, 08906
    - Hospital de Sant Joan Despí
- Valencia
  - Valencia, Valencia, Spain, 46026
    - Hospital Universitario y Politécnico La Fe
Taiwan
- - Kaohsiung City, Taiwan, 83301
    - Chang Gung Memorial Hospital - Kaohsiung Branch
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital_Dept of Internal medicine
  - Taipei, Taiwan, 110
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 104
    - Taipei Mackay Memorial Hospital
  - Taoyuan, Taiwan, 333
    - Chang Gung Memorial Hospital, Linkou
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01060
    - Adana Şehir Eğitim ve Araştırma Hastanesi
  - Adapazarı/Sakarya, Turkey (Türkiye), 54100
    - Sakarya Eğitim ve Araştırma Hastanesi- Dahiliye
  - Afyonkarahisar, Turkey (Türkiye), 03200
    - Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
  - Altınordu/Ordu, Turkey (Türkiye), 52200
    - Ordu Üniversitesi Eğitim ve Araştırma Hastanesi- Kardiyoloji
  - Ankara, Turkey (Türkiye), 06800
    - Ankara Bilkent Şehir Hastanesi-Dahiliye
  - Ankara, Turkey (Türkiye), 06800
    - Ankara Bilkent Şehir Hastanesi-Kardiyoloji
  - Antalya, Turkey (Türkiye), 07059
    - Akdeniz Üniversitesi Hastanesi-Kardiyoloji
  - Bayraklı/İzmir, Turkey (Türkiye), 35540
    - İzmir Şehir Hastanesi- Kardiyoloji
  - Bursa, Turkey (Türkiye), 16310
    - Bursa Yüksek İhtisas Eğitim ve Araştırma Merkezi-Kardiyoloji
  - Eskişehir, Turkey (Türkiye), 26080
    - Eskişehir Şehir Hastanesi- Kardiyoloji
  - Eskişehir, Turkey (Türkiye), 26040
    - Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
  - Istanbul, Turkey (Türkiye), 34098
    - İstanbul Üniversitesi-Cerrahpaşa Tıp Fakültesi Kardiyoloji Enstitüsü
  - Istanbul, Turkey (Türkiye), 34668
    - Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
  - Istanbul, Turkey (Türkiye), 34303
    - Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH
  - Istanbul, Turkey (Türkiye), 34854
    - Marmara Üniversitesi Pendik EAH- Kardiyoloji
  - Izmir, Turkey (Türkiye), 35340
    - Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
  - Izmir, Turkey (Türkiye), 35360
    - İzmir Atatürk Eğitim Ve Araştırma Hastanesi- Kardiyoloji
  - Kayseri, Turkey (Türkiye), 38039
    - Erciyes Üniversitesi Hastanesi- Kardiyoloji
  - Kayseri, Turkey (Türkiye), 38080
    - Kayseri Şehir Hastanesi-Kardiyoloji
  - Keçiören/Ankara, Turkey (Türkiye), 06010
    - Gülhane Eğitim ve Araştırma Hastanesi- Kardiyoloji
  - Kocaeli, Turkey (Türkiye), 41380
    - Kocaeli Üniversitesi Hastanesi- Kardiyoloji
  - Kütahya, Turkey (Türkiye), 43100
    - Kütahya Şehir Hastanesi-Kardiyoloji
  - Malatya, Turkey (Türkiye), 44280
    - İnönü Üniversitesi Turgut Özal Tıp Merkezi - Kardiyoloji
  - Merkez/elaziğ, Turkey (Türkiye), 23119
    - Fırat Üniversitesi Hastanesi- Kardiyoloji
  - Mersin, Turkey (Türkiye), 33343
    - Mersin Üniversitesi Hastanesi- Kardiyoloji
  - Muratpasa/ Antalya, Turkey (Türkiye), 07100
    - Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji
  - Samsun, Turkey (Türkiye), 55090
    - Samsun Eğitim ve Araştırma Hastanesi-Kardiyoloji
  - Yenimahalle/Ankara, Turkey (Türkiye), 06170
    - Ankara Etlik Şehir Hastanesi- Kardiyoloji
  - Yuregir/Adana, Turkey (Türkiye), 01060
    - Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye
  - Çanakkale/Türkiye, Turkey (Türkiye), 17020
    - Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi- Kardiyoloji
United Kingdom
- - Barnet, United Kingdom, EN5 3DJ
    - Barnet Hospital - Cardiology Department
  - Belfast, United Kingdom, BT16 1RH
    - Ulster Hospital
  - Bridgend, United Kingdom, CF31 1RQ
    - Princess of Wales Hospital
  - Bristol, United Kingdom, BS10 5NB
    - Southmead Hospital - Cardiology Research
  - Chesterfield, United Kingdom, S44 5BL
    - Chesterfield Royal Hospital
  - Coventry, United Kingdom, CV2 2DX
    - University Hospital Coventry - Cardiology Research PRI Suite
  - Craigavon, United Kingdom, BT63 5QQ
    - Craigavon Area Hospital_Cardiovascular Research Unit
  - Dundee, United Kingdom, DD1 9SY
    - Ninewells Hospital
  - Eastbourne, United Kingdom, BN21 2UD
    - Eastbourne Distirct General Hospital - Cardiology
  - Harrow, United Kingdom, HA1 3UJ
    - Northwick Park Hospital - Cardiac Research Dept
  - Inverness, United Kingdom, IV2 3JH
    - Raigmore Hospital
  - Kirkcaldy, United Kingdom, KY2 5AH
    - Victoria Hospital
  - Leicester, United Kingdom, LE3 9QP
    - Glenfield Hospital - Cardiovascular Research
  - Lincoln, United Kingdom, LN2 5QY
    - Lincoln County Hospital
  - Liverpool, United Kingdom, L9 7AL
    - Aintree University Hospital
  - London, United Kingdom, EC1A 7BE
    - St Bartholomew's Hospital
  - London, United Kingdom, TW7 6AF
    - West Middlesex University Hospital
  - London, United Kingdom, SE5 9RS
    - Kings College Hospital - Cardiology
  - Middlesbrough, United Kingdom, TS4 3BW
    - The James Cook University Hospital - Cardiology
  - Newcastle upon Tyne, United Kingdom, NE1 4LP
    - Royal Victoria Infirmary
  - North Shields, United Kingdom, NE29 8NH
    - North Tyneside General Hospital
  - Oldham, United Kingdom, OL1 2JH
    - The Royal Oldham Hospital
  - Plymouth, United Kingdom, PL6 8DH
    - Derriford Hospital
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Sunderland, United Kingdom, SR4 7TP
    - Sunderland Royal Hospital
  - Taunton, United Kingdom, TA1 5DA
    - Musgrove Park Hospital - Cardiology
  - Wakefield, United Kingdom, WF1 4DG
    - Pinderfields Hospital - Clinical Research & Innovation
  - Worcester, United Kingdom, WR5 1DD
    - Worcestershire Royal Hospital_Cardiology
- Cornwall
  - Truro, Cornwall, United Kingdom, TR1 3LJ
    - Royal Cornwall Hospital (Treliske)
- Denbighshire
  - Rhyl, Denbighshire, United Kingdom, LL18 5UJ
    - Glan Clwyd Hospital - North Wales Cardiac Centre
- Devon
  - Torquay, Devon, United Kingdom, TQ2 7AA
    - Torbay Hospital
- Dorset
  - Dorchester, Dorset, United Kingdom, DT1 2NQ
    - Dorset County Hospital
- Lanarkshire
  - Airdrie, Lanarkshire, United Kingdom, ML6 0JS
    - University Hospital Monklands - Cardiology Research
- London
  - Tooting, London, United Kingdom, SW17 0RE
    - St George's Hospital - Cardiology
- Norfolk
  - Norwich, Norfolk, United Kingdom, NR4 7UY
    - Norfolk and Norwich University Hospital - Clinical Research Facility
- Warwickshire
  - Nuneaton, Warwickshire, United Kingdom, CV10 7DJ
    - George Eliot Hospital
- West Sussex
  - Chichester, West Sussex, United Kingdom, PO19 6SE
    - St. Richard's Hospital_Cardiology
United States
- Alabama
  - Alexander City, Alabama, United States, 35010
    - Advanced Cardiovascular, LLC
  - Birmingham, Alabama, United States, 35233
    - Univ of Alabama Birmingham
  - Fairhope, Alabama, United States, 36532
    - Eastern Shore Rsrch Inst, LLC
  - Mobile, Alabama, United States, 36608
    - Mobile Heart USA Health Cardiology Clinic
- Arizona
  - Gilbert, Arizona, United States, 85297
    - Mercy Gilbert Medical Center
  - Glendale, Arizona, United States, 85304
    - Sun City Clinical Research
  - Phoenix, Arizona, United States, 85006
    - Honor Health
  - Phoenix, Arizona, United States, 85016
    - Arizona Research Center
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Health Group
- California
  - Alhambra, California, United States, 91801
    - InvivoCure -2
  - Beverly Hills, California, United States, 90210
    - Cardio Research of S. Cal
  - Beverly Hills, California, United States, 90211
    - Westside Medical Associates Los Angeles
  - Chula Vista, California, United States, 91910
    - Scripps Hospital
  - Concord, California, United States, 94520
    - John Muir Physicians Network
  - Covina, California, United States, 91723
    - Valley Clinical Trials
  - Fremont, California, United States, 94538
    - Mission Cardiovascular Research Institute
  - Granada Hills, California, United States, 91344
    - Amicis Research Center
  - Huntington Beach, California, United States, 92648-1717
    - California Heart Specialist
  - Irvine, California, United States, 92612
    - Joe C.Wen & Fam CTR for Adv Care
  - La Jolla, California, United States, 92037
    - Scripps Memorial Hospital La Jolla
  - La Jolla, California, United States, 92037
    - UCSD NAFLD Research Center
  - Long Beach, California, United States, 90813
    - Cardio Innovation & Resch Ctr
  - Los Alamitos, California, United States, 90720
    - Pacific Clinical Studies
  - Los Angeles, California, United States, 90073
    - VAGrtrLosAngelesHlthcareSystem
  - Northridge, California, United States, 91324
    - Amicis Research Center
  - Northridge, California, United States, 91325
    - Valley Clinical Trials
  - Northridge, California, United States, 91324
    - JPJ Research
  - Palm Springs, California, United States, 92262
    - Desert Oasis Healthcare
  - Pomona, California, United States, 91767
    - Empire Clin. Research
  - San Diego, California, United States, 92117
    - G&J Research
  - San Diego, California, United States, 92161
    - San Diego Veterans Affairs
  - San Francisco, California, United States, 94118
    - Kaiser Permanente Northern California
  - San Francisco, California, United States, 94121
    - San Francisco V.A. Medical Center
  - Santa Maria, California, United States, 93454
    - Fomat Medical Research
  - Santa Rosa, California, United States, 95405
    - NorthBay Clinical Research
  - South Gate, California, United States, 90280
    - JPJ Research
  - Stockton, California, United States, 95204
    - St. Joseph's Medical Center
  - Tarzana, California, United States, 91356
    - Valiance Clinical Research
  - Thousand Oaks, California, United States, 91360
    - Care Access Research
  - Van Nuys, California, United States, 91405
    - InvivoCure
  - Vista, California, United States, 92081
    - Blue Coast Research Center
  - West Hills, California, United States, 91307
    - Interventional Cardiology Medical Group
- Colorado
  - Aurora, Colorado, United States, 80045
    - VA Eastern Colorado Health Care System
  - Aurora, Colorado, United States, 80045
    - Univ of Colorado at Denver
  - Denver, Colorado, United States, 80218
    - Intermountain Heart & Vascular
  - Golden, Colorado, United States, 80401
    - Colorado Heart and Vascular PC
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20037
    - The GW Medical Faculty Associates
- Florida
  - Clearwater, Florida, United States, 33756
    - BayCare Health System
  - Coral Gables, Florida, United States, 33134
    - Broward Research Ctr.
  - Crystal River, Florida, United States, 34429
    - Nature Coast Clinical Research
  - Daytona Beach, Florida, United States, 32117
    - Arrow Clinical Trials
  - Florida City, Florida, United States, 33034
    - Inpatient Research Clinic LLC
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Ctr For Clin Res
  - Maitland, Florida, United States, 32751
    - K2 Medical Research
  - Miami, Florida, United States, 33126
    - Total Research Group LLC
  - Miami, Florida, United States, 33169
    - Future Life Clinical Trials
  - Miami, Florida, United States, 33133-4223
    - Infinite Clinical Research
  - Miami Beach, Florida, United States, 33140
    - Broward Research Ctr.
  - Miami Lakes, Florida, United States, 33014
    - Inpatient Research Clinic LLC
  - New Port Richey, Florida, United States, 34652
    - Suncoast Clinical Research, Inc.
  - Ocala, Florida, United States, 34471
    - Ocala Cardiovascular Research
  - Orlando, Florida, United States, 32807
    - Cardiovascular Institute of Orlando
  - Ormond Beach, Florida, United States, 32174
    - Ormond Beach Clinical Research
  - Pembroke Pines, Florida, United States, 33029-1406
    - DBC Research - Pembroke Pines
  - Pensacola, Florida, United States, 32503
    - SEC Clinical Research
  - Safety Harbor, Florida, United States, 34695
    - Clearwater Cardiovascular Consultants
  - Sarasota, Florida, United States, 34239
    - Intercoastal Medical Group
  - Tampa, Florida, United States, 33614
    - Tampa Cardiovascular Interventions and Research
  - Tampa, Florida, United States, 33614
    - St Joseph's Hospital Foundation
  - Virginia Gardens, Florida, United States, 33166
    - Hope Research Network
  - Winter Park, Florida, United States, 32792
    - Guardian Research Org LLC
- Georgia
  - Acworth, Georgia, United States, 30101
    - American Clinical Trials, LLC
  - Atlanta, Georgia, United States, 30342
    - Atlanta Center for Clinical Research_Atlanta
  - Conyers, Georgia, United States, 30094
    - Hope Clin Res & Wellness
  - Conyers, Georgia, United States, 30012
    - East Atlanta Cardiology
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Medical Ctr
  - Johns Creek, Georgia, United States, 30024
    - NSC Research, Inc
  - Peachtree, Georgia, United States, 30269
    - Peachtree Cardiology
  - Thomasville, Georgia, United States, 31792
    - Cardiovascular Consultants of South Georgia
  - Tucker, Georgia, United States, 30084
    - Atlanta Heart Specialists, LLC
- Hawaii
  - Honolulu, Hawaii, United States, 96813
    - The Queen's Medical Center
- Idaho
  - Meridian, Idaho, United States, 83642
    - St. Luke's Idaho Cardiology Associates
  - Meridian, Idaho, United States, 83642
    - High Desert Heart and Vascular PLLC
- Illinois
  - Chicago, Illinois, United States, 60621
    - Eagle Clinical Research
  - Chicago, Illinois, United States, 60607
    - Chicago Clinical Research Institute Inc
  - Chicago, Illinois, United States, 60612
    - Univer Of Illinois at Chicago
  - Hazel Crest, Illinois, United States, 60429
    - Chicago Medical Research LLC
  - Orland Park, Illinois, United States, 60462
    - Chicago Medical Research LLC
  - Peoria, Illinois, United States, 61606
    - UnityPoint Health-Diabetes Care Center
- Indiana
  - Hammond, Indiana, United States, 46324
    - Asha Clinical Rsch-Munster, LLC
  - Indianapolis, Indiana, United States, 46202
    - Indiana University Health Methodist Hosptial
- Iowa
  - Davenport, Iowa, United States, 52801
    - Midwest Cardiovascu Rsrch Foundation
  - Iowa City, Iowa, United States, 52242
    - University of Iowa
- Kansas
  - Wichita, Kansas, United States, 67226
    - West Houston Area Clinical Trial Consultants
- Kentucky
  - Lexington, Kentucky, United States, 40503
    - The Research Group of Lexington LLC
  - Louisville, Kentucky, United States, 40202
    - UofL Health Care Outpatient
  - Owensboro, Kentucky, United States, 42303
    - Owensboro Medical Practice OMP
- Louisiana
  - Bossier City, Louisiana, United States, 71111
    - Grace Research, LLC
  - Eunice, Louisiana, United States, 70535
    - Horizon Research Group of Opelousas, LLC
  - Houma, Louisiana, United States, 70360-4413
    - Cardiovascular Institute of the South
  - Opelousas, Louisiana, United States, 70570
    - Cardiovascular Institute of the South
  - Shreveport, Louisiana, United States, 71105
    - Grace Research, LLC_Shreveport
- Maine
  - Scarborough, Maine, United States, 04074
    - Maine Medical Center Bramhall
- Maryland
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Ca
  - Baltimore, Maryland, United States, 21229
    - Mercy Medical Center, GI Research
  - Ft. Washington, Maryland, United States, 20744
    - Anderson Medical Group
  - Rockville, Maryland, United States, 20850
    - Adventist HealthCare Shady Grove Medical Center
- Michigan
  - Bloomfield Hills, Michigan, United States, 48304
    - Cardio and Vascular Assoc-CAVA
  - Grand Rapids, Michigan, United States, 49525
    - Corewell Health
  - Lansing, Michigan, United States, 48912
    - University of Michigan
  - Southfield, Michigan, United States, 48075
    - Henry Ford Health System
  - Ypsilanti, Michigan, United States, 48197
    - Trinity Health Michigan Heart
- Mississippi
  - Diamondhead, Mississippi, United States, 39525
    - Hawthorne Health
  - Jackson, Mississippi, United States, 39216
    - Univ of Mississippi Med Center
- Missouri
  - Kansas City, Missouri, United States, 64111
    - Clinical Research Consultants, JCCT Co
  - St Louis, Missouri, United States, 63110
    - Washington University
  - St Louis, Missouri, United States, 63128
    - Amicis Centers of Clinical Research
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Bryan Heart
  - Lincoln, Nebraska, United States, 68510
    - Velocity Clinical Research Lincoln
- Nevada
  - Las Vegas, Nevada, United States, 89128
    - Palm Research Center Inc-Vegas
  - Las Vegas, Nevada, United States, 89102
    - UMC of Southern Nevada
- New Jersey
  - Elmer, New Jersey, United States, 08318
    - Cardiovascular Associates of the Delaware Valley
  - Hackettstown, New Jersey, United States, 07840
    - Advanced Cardiology LLC - Hackettstown
  - Haddon Heights, New Jersey, United States, 08035
    - The Heart House Haddon Heights
  - Paramus, New Jersey, United States, 07652
    - The Valley Hospital Paramus
  - Sewell, New Jersey, United States, 08080
    - Cardiovascular Associates of the Delaware Valley
  - Somerset, New Jersey, United States, 08873
    - Cardio Metabolic Institute
- New York
  - Albany, New York, United States, 12211
    - Capital Cardiology Associates_Albany
  - Brooklyn, New York, United States, 11221
    - Clindove Research
  - New York, New York, United States, 10016
    - NYU Langone Health
  - New York, New York, United States, 10032
    - Columbia University Medical Center_New York
  - New York, New York, United States, 10001
    - NYU Langone Med Assoc Chelsea
  - New York, New York, United States, 10029
    - Mount Sinai Hosp at NYC
  - Rochester, New York, United States, 14642
    - University of Rochester
  - Rosedale, New York, United States, 11422
    - Laurelton Heart Specialist PC
  - Valhalla, New York, United States, 10595
    - Westchester Medical Center
- North Carolina
  - Apex, North Carolina, United States, 27502
    - Peak Clinical Trials
  - Concord, North Carolina, United States, 28025
    - Hawthorne Health NC
  - Greenville, North Carolina, United States, 27834
    - Physicians East Endocrinology
  - Lenoir, North Carolina, United States, 28645
    - Cross River Cardiology PLLC
  - Raleigh, North Carolina, United States, 27610
    - WakeMed_Cardiology
  - Statesville, North Carolina, United States, 29625
    - PHC Accelacare
  - Wilmington, North Carolina, United States, 28401
    - Accellacare Wilmington
- Ohio
  - Canton, Ohio, United States, 44710
    - Aultman Hospital
  - Cincinnati, Ohio, United States, 45219
    - Lindner Center,Christ Hospital
  - Cleveland, Ohio, United States, 44106
    - Louis Stokes Clvlnd VA Med Ctr
  - Dayton, Ohio, United States, 45439
    - Providence Health Partners Ctr
  - Marion, Ohio, United States, 43302
    - K&R Research LLC
  - Maumee, Ohio, United States, 43537
    - Advanced Medical Research
  - Vandalia, Ohio, United States, 45377
    - STAT Research Ohio
- Oregon
  - Portland, Oregon, United States, 97239-3011
    - Oregon Health & Science University
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Penn State Hlth Holy Spirit Med Ctr
  - Chambersburg, Pennsylvania, United States, 17201
    - Chambersburg Hospital
  - Doylestown, Pennsylvania, United States, 18901
    - Doylestown Heath cardiology
  - Lancaster, Pennsylvania, United States, 17603
    - Penn Med. Lancaster Gen Hospital
  - Philadelphia, Pennsylvania, United States, 19107
    - Thomas Jefferson University
- South Carolina
  - Charleston, South Carolina, United States, 29412
    - Med. Uni. of SC Ashley River T
  - Fort Mill, South Carolina, United States, 29707
    - Piedmont Research Partners, LLC
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Monument Health Clinical Rsrch
- Tennessee
  - Greeneville, Tennessee, United States, 37745
    - Balad Hlth Sys-Welmont CardCVA
  - Jackson, Tennessee, United States, 38305
    - The Jackson Clinic, PA
- Texas
  - Amarillo, Texas, United States, 79106
    - PharmaTex Research, LLC
  - Austin, Texas, United States, 78705
    - Austin Heart
  - Conroe, Texas, United States, 77384
    - Javara Inc. / Privia Medical Group Gulf Coast PLLC
  - Corpus Christi, Texas, United States, 78404
    - South Texas Clinical Research
  - Dallas, Texas, United States, 75204
    - Renal Disease Research Institute
  - Dallas, Texas, United States, 75231
    - Texas Health Heart and Vascular Specialists
  - Dallas, Texas, United States, 75235
    - Southwest Family Medicine_Dallas
  - Dallas, Texas, United States, 75390
    - UTD SW Medical Center-Dallas
  - Denison, Texas, United States, 75020
    - Texama Medical Center
  - Duncanville, Texas, United States, 75137
    - Dallas Heart and Vascular
  - El Paso, Texas, United States, 79905
    - David Turbay, MD, PLLC
  - El Paso, Texas, United States, 79902
    - Proactive El Paso LLC
  - Forney, Texas, United States, 75126
    - Care United Research, LLC
  - Fort Worth, Texas, United States, 76104
    - Baylor Scott & White Health
  - Houston, Texas, United States, 77002
    - East Texas Cardiology PA
  - Houston, Texas, United States, 77024
    - Victorium Clinical Research
  - Houston, Texas, United States, 77070
    - Card Specialists of Willowbrook
  - Houston, Texas, United States, 77025
    - Main Heart Clinic
  - McAllen, Texas, United States, 78503
    - Biopharma Informatic, LLC
  - McKinney, Texas, United States, 75071
    - North Texas Research Associates
  - Plano, Texas, United States, 75093
    - Baylor Scott & White Res Inst
  - Round Rock, Texas, United States, 78665
    - Baylor Scott & White Health
  - San Antonio, Texas, United States, 78229
    - Flourish Research
  - San Antonio, Texas, United States, 78207
    - University Hospital
  - San Marcos, Texas, United States, 78666
    - Austin Heart
  - Sherman, Texas, United States, 75092
    - Medrasa Clinical Research
  - Sherman, Texas, United States, 75090
    - Sherman Clinical Research
  - Temple, Texas, United States, 76508
    - Baylor Scott & White Health
- Utah
  - Murray, Utah, United States, 84107
    - Intermountain Medical Center
- Virginia
  - Arlington, Virginia, United States, 22205
    - Conquest Research
  - Manassas, Virginia, United States, 20109
    - Carient Heart and Vascular
  - Newport News, Virginia, United States, 23606
    - TPMG Clinical Research
  - Norfolk, Virginia, United States, 23507
    - Sentara Health Research Center
  - Richmond, Virginia, United States, 23298
    - Virginia Commonwealth University
  - Winchester, Virginia, United States, 22601-3834
    - Selma Medical Associates
- Washington
  - Seattle, Washington, United States, 98122
    - Swedish Medical Center_Seattle
  - Tacoma, Washington, United States, 98405
    - CHI Franciscan Research Center
- West Virginia
  - Morgantown, West Virginia, United States, 26506
    - WVU Medicine
- Wisconsin
  - Marshfield, Wisconsin, United States, 54449
    - Marshfield Clinic
  - Milwaukee, Wisconsin, United States, 53215
    - Aurora St. Luke's Medi Ctr
  - Wausau, Wisconsin, United States, 54401
    - Cardio Research & Education Foundation

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Body Mass Index (BMI) greater than or equal to (>=) 30 kilograms per square metre (kg/m^2) at screening.
Diagnosis of HF with New York Heart Association (NYHA) class II-IV and in stable condition at screening, at the discretion of the investigator.

For participants with Type 2 Diabetes (T2D) at screening:

- Diagnosed with T2D >= 30 days before screening.

Exclusion Criteria:

MI, stroke, unstable angina pectoris or worsening HF leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization.
HF due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, Chagas cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, or uncorrected primary valve disease of moderate or severe degree.
Severe pulmonary disease including primary pulmonary hypertension, chronic pulmonary embolism, or severe chronic obstructive pulmonary disease (COPD) defined as:
requiring home oxygen; or - ongoing oral corticosteroid therapy; or - hospital for COPD Exacerbation within 12 months prior to screening.
Any other condition judged by the investigator to be the cause of HF symptoms (e.g., anaemia, hypothyroidism).

Glycaemia-related:

History of type 1 diabetes.
Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or who, at the time of screening, are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
Glycated haemoglobin (HbA1c) greater than (>) 10 percent (%) (86 [millimoles per mole] mmol/mol) as measured by local or central laboratory at screening.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: NNC0487-0111 Participants will receive NNC0487-0111 subcutaneously (s.c.) in a dose escalating manner once weekly.	Drug: NNC0487-0111 NNC0487-011 will be administered subcutaneously.
Placebo Comparator: Placebo Participants will receive placebo matched to NNC0487-011 s.c. once weekly.	Drug: Placebo Placebo will be administered subcutaneously.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of a composite Heart Failure (HF) endpoint consisting of cardiovascular (CV) death Time Frame: From baseline (week 0) to 165 weeks	Measured in days.	From baseline (week 0) to 165 weeks
Time to first occurrence of a composite HF endpoint consisting of HF hospitalisation or urgent HF visit Time Frame: From baseline (week 0) to 165 weeks	Measured in days.	From baseline (week 0) to 165 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of a composite HF and Major Adverse Cardiovascular Events (MACE) end-point consisting of: CV death, HF hospitalisation or urgent HF visit, Nonfatal Myocardial Infraction (MI), Nonfatal stroke Time Frame: From baseline (week 0) to 165 weeks	Measured in days.	From baseline (week 0) to 165 weeks
Change in Clinical Summary Score of the Kansas City Cardiomyopathy Questionnaire (KCCQ-CSS) for participants with baseline KCCQ-CSS score less than (<) 80 points Time Frame: From baseline (week 0) to week 52	Measured as score on scale. KCCQ measures Health-Related Quality of Life (HRQOL). Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms and greater disease-specific HRQoL.	From baseline (week 0) to week 52
Change in estimated Glomerular Filtration Rate (eGFR) (creatinine and cystatin C-based Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] 2021) for participants with baseline eGFR< 60 millilitre per minute per 1.73 square metre (mL/min/1.73 m^2) Time Frame: From baseline (week 0) to week 78	Measured as mL/min/1.73 m^2.	From baseline (week 0) to week 78
Time to all-cause death Time Frame: From baseline (week 0) to 165 weeks	Measured in days.	From baseline (week 0) to 165 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Novo Nordisk A/S

Investigators

Study Director: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

May 11, 2026

Primary Completion (Estimated)

July 23, 2029

Study Completion (Estimated)

August 15, 2029

Study Registration Dates

First Submitted

April 28, 2026

First Submitted That Met QC Criteria

April 28, 2026

First Posted (Actual)

May 5, 2026

Study Record Updates

Last Update Posted (Actual)

May 5, 2026

Last Update Submitted That Met QC Criteria

April 28, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

NN9490-8266
U1111-1328-2701 (Other Identifier: World Health Organization (WHO))
2025-523717-29 (Other Identifier: European Medical Agency (EMA))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Study record dates

Study Major Dates

Study Start (Estimated)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Heart Failure

Clinical Trials on Placebo

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