Evaluation of an Instructional Video About Medication Management During Admission and Medication Adherence for Kidney Transplantation and in the Outpatient Clinic in a Dutch University Hospital. (MediT)

The goal of this RCT is to evaluate the effect of the instructional video on improving patient compliance and reducing medication errors. The study will include adult kidney transplant recipients (18 years or older) at Erasmus MC who have undergone a kidney transplantation starting January 2026.

The main questions it aims to answer:

The primary aim of this study is to assess whether our developed video instruction, compared with the traditional verbal instruction, both of which are given shortly before training during admission, reduces the number of medication errors in kidney transplant patients.

The study will also examine the correlation between patient characteristics (such as age, comorbidities, and language proficiency) and medication errors. Additionally, patient-reported medication errors will be measured through a questionnaire completed during follow-up visits at the outpatient clinic, which is part of standard care.

The instructional video will be evaluated by a short questionnaire.

Study Overview

• Status: Not yet recruiting
• Conditions: Medication Adherence; Kidney Transplant; Adult; Instruction Videos
• Intervention / Treatment: Other: Instructional video about medication administration

• Study Type: Interventional
• Enrollment (Estimated): 308
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Myrthe van der Zanden, MSc, Drs; Phone Number: +31650094899; Email: m.vanderzanden@erasmusmc.nl

Study Locations

• Netherlands
  • Rotterdam, Netherlands, 3015GD
    • Erasmus Medical Center
    • Contact: Myrthe van der Zanden, MSc, Drs.; Phone Number: +31650094899; Email: m.vanderzanden@erasmusmc.nl

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• The patient is able to take the medication independently or with the help of someone else (professionals not included).
• After admission, the patient is discharged to their own home or home of friend/relative.
• The patient had a follow up at the outpatient clinic in the Erasmus Medical Center for at least one year after transplantation.
• The patient is able to read the medication list or an illiteracy-friendly medication list.

Exclusion Criteria:

• Patients under 18 years of age
• Patients who got discharged with a medication dispenser
• Refusal to participate in the study.
• Cognitive impairments that hinder participation.
• Patients and/or family who can not understand (language barrier) the instructional video.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Verbal instruction; Patients receive the verbal instruction about medication training from the nurses.
Experimental: Video instruction; Patients receive the instruction video about medication training from the nurses.	Other: Instructional video about medication administration; Self developed instructional video for a Dutch university hospital, for Dutch kidney transplant patients. Instructional video is about medication administration during admission.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence and type of medication errors during admission	The primary outcome of this study will be the incidence (number of medication errors) and type of medication errors ( 1)Medication preparation omitted, 2) Incorrect dosage, 3) Incorrect administration at the scheduled time, 4), Medication discontinued inappropriately, 5)Error not documented by the nurse) during admission, evaluated through direct observation by healthcare providers. These errors will be documented and reported via patient portals by nurses.	During admission

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Patient characteristics	Age (in years), gender (male/female/nonbinair), country of origin, language proficiency, number of previous organ transplantations, donor type of the kidney transplant (DCD, DBD, Living), and renal replacement therapy (HD/PD/Pre-emptive).	During admission
Evaluation of the instructional video	Structured questionnaire with the following questions: Was the instructional video clear and easy to understand? (open answer); Did you find the instructional video easy to follow? (open answer); Do you have any suggestions for improvements? (open answer)	At the end of admission
BAASIS	Participants will complete a patient-reported questionnaire (BAASIS) every three months during the first year after transplantation. The questionnaire consists of five yes/no questions related to medication errors occurring in the home setting. The questions will ask whether the participant has: Forgotten to take their medication, (yes/no); Taken the wrong dose of medication, (yes/no); Taken medication at the wrong time, (yes/no); Mixed up medications, (yes/no); Not taken their medication due to confusion or difficulty. (yes/no) The goal is to evaluate whether there is a reduction in home-reported medication errors for those who receive a different medication management training method in the hospital.	During the first year follow up at the out patient clinic after kidney transplantation in the Erasmus MC

Collaborators and Investigators

• Sponsor: Erasmus Medical Center
• Investigators: Study Chair: Jacqueline van de Wetering, MD, Dr., Erasmus Medical Center

Study record dates

Study Major Dates

• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): May 31, 2027
• Study Completion (Estimated): December 31, 2027

Study Registration Dates

• First Submitted: March 12, 2026
• First Submitted That Met QC Criteria: May 11, 2026
• First Posted (Actual): May 18, 2026

Study Record Updates

• Last Update Posted (Actual): May 18, 2026
• Last Update Submitted That Met QC Criteria: May 11, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Behavior; Treatment Adherence and Compliance; Health Behavior; Patient Compliance; Patient Acceptance of Health Care; Medication Adherence
• Other Study ID Numbers: 14372

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No