Outcomes for Patients Who Preserved Their Fertility as Part of Cancer Treatment at the Center for the Study and Preservation of Eggs and Sperm: MaPreservFerti (MaPreservFerti)

May 15, 2026 updated by: Hospices Civils de Lyon

Outcomes for Patients Who Preserved Their Fertility as Part of Cancer Treatment at the Center for the Study and Preservation of Eggs and Sperm (CECOS) in Lyon Between 2010 and 2024: an Assessment of Male Parenthood. MaPreservFerti

Improvements in diagnostic methods and cancer treatments have led to a steady increase in survival rates. The 5-year survival rate for men diagnosed with cancer between the ages of 15 and 39 has exceeded 81%. As a result, quality of life-and in particular, addressing the issue of parenthood-has become essential.

Cancer treatments-surgery, radiation therapy, and chemotherapy-can significantly impair fertility. They may cause sexual dysfunction (anejaculation, anerection), androgen deficiency, or permanent impairment of spermatogenesis. Yet the desire for parenthood ranks among the top three life goals of patients newly diagnosed with cancer, and 50% of patients wish to have a child in the future. Preserving male fertility is therefore a crucial issue.

Before puberty, this can be done by taking a testicular tissue sample, although this is still considered experimental. After puberty, a sample taken from ejaculate allows for the storage of sperm straws.

Thus, when a couple wishes to conceive, following a potential reassessment of spermatogenesis if it is impaired, Assisted Reproductive Technology (ART) can be performed with or without the frozen sperm.

According to the literature, the sperm is typically used within 10 years of fertility preservation. Little data has been collected regarding whether men with a history of cancer conceive naturally or not. It is therefore important to gather this information regarding fatherhood, particularly whether men with a history of cancer have used ART or not, and whether frozen sperm was used or not, based on the results of the follow-up semen analysis performed after treatment.

Primary objective To describe fertility-whether spontaneous or following assisted reproductive technology (ART)-with or without the use of preserved gametes, among patients who underwent fertility preservation for cancer treatment at the CECOS in Lyon between 2010 and 2024.

Secondary objective:

To assess the population of men who preserved their fertility prior to cancer treatment at the Center for the Study and Preservation of Eggs and Sperm (CECOS) in Lyon between 2010 and 2024, specifically:

  • The number and clinical and epidemiological characteristics of the patients.
  • Describe post-cancer fertility
  • Understand CECOS's care protocols to improve the patient care pathway.
  • Describe the psychological difficulties at the time of collection that prevented the procedure and thus the preservation of fertility.
  • Determine the fate of preserved straws that were not used

Methodology:

  • Retrospective analysis of data from the CECOS in Lyon between 2010 and 2024.
  • Information collected from the database: patient age, indication, type of fertility preservation performed (testicular tissue or ejaculate)
  • Subsequently, a paper and electronic questionnaire was sent to these same patients to collect data on their fertility following fertility preservation.
  • Information collected via the questionnaires: marital status, place of residence, paternity prior to cancer, type of cancer, treatment received, achievement of pregnancy after cancer and method (spontaneous pregnancy, reuse of straws at the center, or ART at another center), donation of gametes to research, or destruction if unused.

The CECOS in Lyon is an integral part of the Department of Reproductive Medicine and Biology at the Hopsices Civils de Lyon.

Population studied: This study focuses on patients with a history of cancer who underwent gonadotoxic treatment and preserved their fertility at the CECOS in Lyon between 2010 and 2024

Inclusion criteria:

This study will include patients who:

  • were between the ages of 18 and 60 at the time of fertility preservation
  • underwent fertility preservation at the CECOS in Lyon between January 1, 2010, and December 31, 2024.
  • underwent fertility preservation in the context of cancer treatment
  • who have indicated their consent to participate in the study by completing the questionnaire

Exclusion criteria:

  • Persons deprived of their liberty by a judicial or administrative decision
  • Persons receiving psychiatric care
  • Persons admitted to a health or social care facility for purposes other than research
  • Adults subject to a legal protection measure (guardianship, conservatorship)

Procedure:

An information sheet will be sent to patients regarding the analysis of their medical data collected during their care, along with a questionnaire (see attached questionnaire) for the collection of prospective data. The materials will be sent either by mail (with a stamped envelope for free return shipping as part of the study) or electronically via a dedicated and secure CECOS email address for email responses.

Number of subjects : 950 Study duration : 1 year

Study location : Center for the Study and Preservation of Eggs and Sperm (CECOS)

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

950

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
    • France
      • Bron, France, France, 69500
        • CECOS, Hôpital Femme Mère Enfant
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients who undergone fertility preservation after gonadotoxic cancer treatments in the Lyon CECOS between 2010 and 2024.

Description

Inclusion Criteria:

  • were between the ages of 18 and 60 at the time of fertility preservation
  • Underwent fertility preservation at the CECOS in Lyon between January 1, 2010, and December 31, 2024.
  • underwent fertility preservation in the context of cancer treatment
  • who have indicated their consent to participate in the study by completing the questionnaire

Exclusion Criteria:

  • Persons deprived of their liberty by a judicial or administrative decision
  • Persons receiving psychiatric care
  • Persons admitted to a health or social care facility for purposes other than research
  • Adults subject to a legal protection measure (guardianship, conservatorship)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Targeted patients

Patients who undergone fertility preservation after gonadotoxic cancer treatments in the Lyon CECOS between 2010 and 2024 will receive a self-assessment form.

After completing it they will return it to the center for analysis
Other: Patient self-assessment form
The self-assessment form will be sent only once. Patients will return it through a pre-stamped envelope joined to the form

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The fertility of patients who underwent fertility preservation for cancer treatment at the CECOS in Lyon between 2010 and 2024.
Time Frame: Day 1

It will be assessed based on the percentage of patients whose partners had a positive pregnancy test:

  • either spontaneously after 12 months of unprotected intercourse

  • or following Assisted Reproductive Technology (ART):

    • with the use of cryopreserved gametes
    • without the use of cryopreserved gametes, as a follow-up semen analysis allowed for the use of non-frozen gametes
    • with the use of donor sperm.
Day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospices Civils de Lyon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

June 1, 2027

Study Registration Dates

First Submitted

May 15, 2026

First Submitted That Met QC Criteria

May 15, 2026

First Posted (Actual)

May 22, 2026

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 15, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 69HCL25_0974
  • 2025-A02363-46 (Other Identifier: ID-RCB)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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