Thyroid Dysfunction in Elderly (Thyroid dysfun)

May 19, 2026 updated by: Marwa Abd Ellatif Ahmed Mohamed, Assiut University

Thyroid Dysfunction and it's Association With Comorbidities and Polypharmacy Among Older Adults in a Tertiary Care Hospital, Assiut_Egypt

Thyroid dysfunction in elderly

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

Thyroid dysfunction is a common endocrine disorder among older adults, with prevalence increasing due to age-related physiological changes and the high burden of chronic diseases (1).

It is estimated that 20-30% of individuals aged 60 years and above have some form of thyroid dysfunction, particularly hypothyroidism (2).

Aging affects thyroid hormone secretion, metabolism, and tissue responsiveness, which may alter thyroid function tests even in the absence of overt disease (3).

In elderly patients, thyroid disorders often present with nonspecific or atypical manifestations such as fatigue, cognitive decline, and weight changes, leading to underdiagnosis (4).

Subclinical thyroid dysfunction is also highly prevalent and frequently detected incidentally (5).

Older adults commonly suffer from multiple comorbidities involving different organ systems, which complicates both clinical presentation and interpretation of thyroid function tests (6).

Thyroid dysfunction has been associated with adverse outcomes, including cardiovascular disease, atrial fibrillation, and increased mortality (7).

Polypharmacy is highly prevalent in this population, with many patients receiving five or more medications concurrently (8).

Several drugs can interfere with thyroid function or its laboratory assessment (9).

Despite the clinical importance of this issue, limited data are available in our locality regarding the combined effect of comorbidities and polypharmacy on thyroid function in older adults. Therefore, this study aims to investigate this association.

Study Type

Observational

Enrollment (Estimated)

187

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.

Description

inclusion criteria: Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.

exclusion criteria: patients previously diagnosed with thyroid dysfunction or currently receiving thyroid related treatment, patients with a history of thyroid malignancy, or with end stage organ failure

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
prevalence of thyroid dysfunction in older adult patients
Time Frame: at baseline
prevalence of thyroid dysfunction in older adult patients in Assiut university hospitals geriatric patients
at baseline
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
Time Frame: at baseline
assess association between comorbidities and polypharmacy on thyroid function among older adult patients
at baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Investigators

  • Study Director: Soheir Mostafa Kasim, Professor, Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 1, 2026

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

November 30, 2027

Study Registration Dates

First Submitted

May 19, 2026

First Submitted That Met QC Criteria

May 19, 2026

First Posted (Actual)

May 26, 2026

Study Record Updates

Last Update Posted (Actual)

May 26, 2026

Last Update Submitted That Met QC Criteria

May 19, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Thyroid Dysfunction in Elderly

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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