Study on the Microbial Environment of Non-small Cell Lung Cancer Based on Mycogenomics and Its Clinical Relevance

August 21, 2026 updated by: youlinghou, 958th Army Hospital of the Chinese People's Liberation Army
This study aims to uncover the characteristics of the fungal flora in non-small cell lung cancer, and to investigate the relationship between pulmonary fungi and the various pathological subtypes, stages, clinical features of non-small cell lung cancer, as well as patient prognosis. It seeks to provide new perspectives for a comprehensive understanding of non-small cell lung cancer, as well as new approaches for its early diagnosis and prognosis assessment.

Study Overview

Status

Recruiting

Conditions

Detailed Description

This project intends to study the structural characteristics and clinical relevance of fungal microbiota in lung tissue of patients with non-small cell lung cancer. The project plans to collect 500 lung tissue samples from patients undergoing lung cancer surgery, build an ecological map of non-small cell lung cancer fungi through high-throughput sequencing, and simultaneously carry out traditional fungi culture to obtain culturable strain resources, so as to build a resource bank of non-small cell lung cancer fungi. By integrating clinicopathological information and follow-up data, using bioinformatics and statistical methods, key landmark fungi were screened, and the correlation between fungal community structure and different pathological subtypes, stages and clinical characteristics of non-small cell lung cancer was analyzed.

This project intends to study the structural characteristics and clinical relevance of fungal microbiota in lung tissue of patients with non-small cell lung cancer. The project plans to collect 500 lung tissue samples from patients undergoing lung cancer surgery, build an ecological map of non-small cell lung cancer fungi through high-throughput sequencing, and simultaneously carry out traditional fungi culture to obtain culturable strain resources, so as to build a resource bank of non-small cell lung cancer fungi. By integrating clinicopathological information and follow-up data, using bioinformatics and statistical methods, key landmark fungi were screened, and the correlation between fungal community structure and different pathological subtypes, stages and clinical characteristics of non-small cell lung cancer was analyzed.

Study Type

Observational

Enrollment (Estimated)

10

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Liangjiang New
      • Chongqing, Liangjiang New, China, 400020
        • Recruiting
        • 958th Army Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The research object is the patients who are newly diagnosed as "non-small cell lung cancer" and intend to undergo surgical resection

Description

Inclusion Criteria:

Non-small cell lung cancer was diagnosed by biopsy before operation, frozen pathology during operation or paraffin section after operation; The patients were 30 to 80 years old; No chemotherapy, radiotherapy, targeted therapy or immunotherapy were given before operation;

Exclusion Criteria:

Patients who do not meet the inclusion criteria; Combined with primary malignant tumor of other systems or recurrence of lung cancer, combined with immunodeficiency disease; Acute exacerbation of chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis with infection, tuberculosis and pneumoconiosis; recent use of antifungal drugs; Basic clinical information (such as pathological type, clinical stage and treatment plan) cannot be obtained;

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Lung cancer group
The samples included in this group were lung cancer tissues.
Normal lung tissue group
The samples included in this group were normal lung tissues.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
the fungal microbial environment
Time Frame: baseline, pre-surgery
Different fungal microbial environments were observed in different parts of lung tissue.
baseline, pre-surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

958th Army Hospital of the Chinese People's Liberation Army

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2026

Primary Completion (Estimated)

January 30, 2028

Study Completion (Estimated)

August 1, 2028

Study Registration Dates

First Submitted

August 1, 2026

First Submitted That Met QC Criteria

August 21, 2026

First Posted (Actual)

August 25, 2026

Study Record Updates

Last Update Posted (Actual)

August 25, 2026

Last Update Submitted That Met QC Criteria

August 21, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • microbial environment

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Study Data/Documents

  1. Study Protocol
    Information identifier: The project has been put on re
    Information comments: The project has been put on record in China medical research filing system.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe