Post-Extraction Wound Healing in Elderly

August 27, 2026 updated by: University of Nebraska
Patients presenting to the UNMC College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and WF will be collected and at 3 months a second xray will be taken.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

72

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • United States
    • Nebraska
      • Lincoln, Nebraska, United States, 68583
        • University of Nebraska Medical Center College of Dentistry
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Study population will be made of patients at the UNMC College of Dentistry requiring posterior extraction, aged 65-80.

Description

Inclusion Criteria:

  • needs posterior tooth extracted
  • no systemic conditions or meds affecting wound healing
  • non-smoker

Exclusion Criteria:

  • systemic conditions or meds known to affect wound healing
  • smokers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
IL1B
Time Frame: Baseline
Measurement of IL1B in GCF, WF
Baseline

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Bone Density
Time Frame: 3 months
Change in bone density post-extraction
3 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Nebraska

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • Dignam P, Elshafey M, Jeganathan A, Foo M, Park JS, Ratnaweera M. Prevalence and Factors Influencing Post-Operative Complications following Tooth Extraction: A Narrative Review. Int J Dent. 2024;2024:7712829. Epub 20240509. doi: 10.1155/2024/7712829. PubMed PMID: 38756385; PMCID: PMC11098612. 2. Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12(12). Epub 20221219. doi: 10.3390/life12122142. PubMed PMID: 36556508; PMCID: PMC9784880. 3. Martin P, Pardo-Pastor C, Jenkins RG, Rosenblatt J. Imperfect wound healing sets the stage for chronic diseases. Science. 2024;386(6726):eadp2974. Epub 20241206. doi: 10.1126/science.adp2974. PubMed PMID: 39636982. 4. Amler MH. Age factor in human alveolar bone repair. J Oral Implantol. 1993;19(2):138-42. PubMed PMID: 8246300. 5. Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018;97(13):1424-30. Epub 20180803. doi: 10.1177/0022034518792567. PubMed PMID: 30075090; PMCID: PMC6854267. 6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering (Basel). 2023;10(10). Epub 20230929. doi: 10.3390/bioengineering10101145. PubMed PMID: 37892875; PMCID: PMC10604628. 7. Sims NA. Influences of the IL-6 cytokine family on bone structure and function. Cytokine. 2021;146:155655. Epub 20210728. doi: 10.1016/j.cyto.2021.155655. PubMed PMID: 34332274. 8. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. Epub 20200623. doi: 10.1055/s-0040-1712718. PubMed PMID: 32575137; PMCID: PMC7440949. 9. Razavi P, Rezaee SA, Akhondian S, Asgari N, Fatemi K, Mohajertehran F. Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

November 1, 2026

Primary Completion (Estimated)

November 1, 2028

Study Completion (Estimated)

November 1, 2030

Study Registration Dates

First Submitted

August 27, 2026

First Submitted That Met QC Criteria

August 27, 2026

First Posted (Actual)

September 1, 2026

Study Record Updates

Last Update Posted (Actual)

September 1, 2026

Last Update Submitted That Met QC Criteria

August 27, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 0672-26-EP

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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