Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

September 1, 2026 updated by: Second Affiliated Hospital of Soochow University
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • China
      • Deyang, China
        • Not yet recruiting
        • Deyang People's Hospital
        • Contact:
          • Ping Zhang
          • Phone Number: +8615883850268
      • Huzhou, China
        • Not yet recruiting
        • Changxing people' s hospital
        • Contact:
          • Donghui Li
          • Phone Number: +8615067223301
      • Nantong, China
        • Not yet recruiting
        • Affiliated Hospital of Nantong University
        • Contact:
          • Xiaosu Gu
          • Phone Number: 13962998759
      • Xuzhou, China
        • Not yet recruiting
        • The Affiliated Hospital of Xuzhou Medical University
        • Contact:
    • Jiangsu
      • Changshu, Jiangsu, China, 215500
        • Recruiting
        • Changshu Hospital Affiliated to Nanjing University of Chinese Medicine
        • Contact:
      • Huai'an, Jiangsu, China, 223001
        • Not yet recruiting
        • The Second People's Hospital of Huai'an
        • Contact:
      • Kunshan, Jiangsu, China, 215300
        • Not yet recruiting
        • The First People's Hospial of Kunshan
        • Contact:
          • Qing, Tang
          • Phone Number: +8618862390859
      • Nanjing, Jiangsu, China, 210000
        • Not yet recruiting
        • Jiangsu Province Official Hospital
        • Contact:
      • Nantong, Jiangsu, China, 226000
        • Not yet recruiting
        • The Second Affiliated Hospital of Nantong University
        • Contact:
          • Jia Li
          • Phone Number: +8613813605009
      • Suqian, Jiangsu, China, 223800
        • Recruiting
        • Jiangsu Province (Suqian) Hospital
        • Contact:
          • Dan Li
          • Phone Number: +8613776468080
      • Suzhou, Jiangsu, China, 215000
        • Recruiting
        • The Second Affiliated Hospital of Soochow University
        • Principal Investigator:
          • Chunfeng Liu
        • Contact:
      • Suzhou, Jiangsu, China, 215000
        • Recruiting
        • The Forth Affiliated Hospital of Soochow University
        • Contact:
      • Xuzhou, Jiangsu, China, 221000
        • Not yet recruiting
        • The Second Affiliated Hospital of Xuzhou Medical University
        • Contact:
      • Yancheng, Jiangsu, China, 224000
        • Recruiting
        • Yancheng Third People's Hospital
        • Contact:
          • Haihua Sun
          • Phone Number: +8615295370576
      • Yangzhou, Jiangsu, China, 225000
        • Not yet recruiting
        • Affiliated Hospital of Yangzhou University
        • Contact:
      • Zhangjiagang, Jiangsu, China, 215600
        • Not yet recruiting
        • Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine Hospital
        • Contact:
      • Zhenjiang, Jiangsu, China, 212000
        • Recruiting
        • The Forth People's Hospital of Zhenjiang
        • Contact:
          • Jinjun Qian
          • Phone Number: +8615358595730
    • Shandong
      • Yantai, Shandong, China, 264000
        • Not yet recruiting
        • Yantai Yuhuangding Hospital
        • Contact:
    • Sichuan
      • Mianyang, Sichuan, China, 621000
        • Not yet recruiting
        • Mianyang 404 Hospital
        • Contact:
    • Zhejiang
      • Jiaxing, Zhejiang, China, 314000
        • Not yet recruiting
        • Jiaxing Second Hospital
        • Contact:
          • Yanping Wang
          • Phone Number: +8613486331646

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients diagnosed with multiple system atrophy (MSA) , dementia with Lewy bodies (DLB) , progressive supranuclear palsy (PSP) , or corticobasal degeneration (CBD) according to Chinese/international consensus diagnostic criteria . Follow-up period : 3 years , with clinical phenotypes and/or biomarkers assessed every 6 months .

Description

Inclusion Criteria:

  1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) .
  2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) .
  3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years .
  4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).

Exclusion Criteria:

  1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure .
  2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Atypical parkinsonian syndromes
Other: We did not apply any interventions; only observational research was conducted.
We did not apply any interventions; only observational research was conducted.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Natural disease progression of various atypical parkinsonian syndromes
Time Frame: up to 36 months
To observe the differences in the natural disease progression of various atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rates of motor and non-motor symptoms and the patterns of imaging evolution. The preliminary study design involves a follow-up period of 3 years, with assessments of clinical phenotypes and/or biomarker changes every 6 months.
up to 36 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Affiliated Hospital of Soochow University

Investigators

  • Study Chair: Chunfeng Liu, Second Affiliated Hospital of Soochow University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 12, 2025

Primary Completion (Estimated)

August 31, 2030

Study Completion (Estimated)

August 31, 2030

Study Registration Dates

First Submitted

November 20, 2025

First Submitted That Met QC Criteria

September 1, 2026

First Posted (Actual)

September 8, 2026

Study Record Updates

Last Update Posted (Actual)

September 8, 2026

Last Update Submitted That Met QC Criteria

September 1, 2026

Last Verified

September 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • JD-LK2025118-I01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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