Search clinical trials for: C1-R212

Total 251 results

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Alvogen Korea

Withdrawn

Clinical Trial to Evaluate the Efficacy and Safety of DP-R212

Hypertension | Hypercholesterolemia
University Hospital, Toulouse

Completed

Combined Deep Brain Stimulation in Parkinson's Disease (SCP-FOG)

Parkinson Disease

France
Shire

Completed

A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE

Hereditary Angioedema

United States
Dong-A ST Co., Ltd.

Completed

Clinical Trial of DA-5212 in Patients with Functional Dyspepsia

Functional Dyspepsia

Korea, Republic of
Novo Nordisk A/S

Completed

A Study Investigating the Safety and Performance of DV3395, a New Concept Device for the Delivery of Medicine.

Healthy Volunteers, Medical Device

Netherlands
CSL Behring
Parexel

Completed

A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route

Hereditary Angioedema Types I and II

United States, Germany
Merck Sharp & Dohme LLC

Withdrawn

A Lot-to-Lot Consistency Study to Evaluate Safety, Tolerability, and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Healthy Adults (V212-014)

Herpes Zoster
Shire

Completed

A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection

Graft Rejection

United States, Germany
CSL Behring

Terminated

Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients

Antibody-mediated Rejection

United States, Spain, France, Netherlands, United Kingdom, Belgium, Germany
CSL Behring
Chiltern International Inc.

Completed

Patient Registry Study of Berinert® in Normal Clinical Practice

Includes: Hereditary Angioedema

United States, Denmark, Germany, Switzerland
Prothya Biosolutions

Completed

C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) Angioedema

Angioedema

Netherlands
Takeda
CRO Axelys Santé DZ

Recruiting

A Study to Learn About the C1-Inhibitor Function as Diagnosis for Hereditary Angioedema (AHAE)

Hereditary Angioedema (HAE)

Algeria
IMMUNOe Research Centers

Completed

A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions

CVI - Common Variable Immunodeficiency

United States
Prothya Biosolutions

Completed

C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) Angioedema

Angioedema

Netherlands
CSL Behring

Completed

A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Germany, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
NYU Langone Health
CSL Behring

Completed

C1-Inhibitor (INH) for Refractory Antibody Mediated Renal Allograft Rejection

Antibody Mediated Rejection of Kidney Transplant

United States
Rothman Institute Orthopaedics

Unknown

Randomized, Controlled Trial of Posterior C1-2 Fusion Versus Bracing Alone for Treatment of Type II Odontoid Process Fractures in the Elderly

Odontoid Fracture

United States
IRCCS San Raffaele

Not yet recruiting

ON-treatment Single-cell Analysis for the Identification of Early Tumor Response Biomarkers on Prospective Collected Serial Tumor Biopsies in Triple Negative Breast Cancer Patient During Standard Neoadjuvant Chemo-immunotherapy (ONSET)

Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Italy
Sohag University

Completed

Surgical Outcome of Type II Odontoid Fracture, Harms Technique

Tramatic Odontoid Fracture

Egypt
Octapharma

Recruiting

Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks

Acute Hereditary Angio Edema

Ukraine, United States, Mexico, Bulgaria, Serbia, Armenia, Montenegro, Turkey (Türkiye), Albania, Argentina, Peru, Romania
CSL Behring

Completed

A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
Nemours Children's Clinic
Children's Mercy Hospital Kansas City

Recruiting

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families (R2D2)

Type 1 Diabetes

United States
Hadassah Medical Organization

Completed

Longitudinal Follow-up After C1 Implant Stabilization Values

Jaw, Edentulous, Partially

Israel
Institut du Cancer de Montpellier - Val d'Aurelle

Not yet recruiting

Analysis of Circulating Tumor Markers in Blood - ALCINA 5 (ALCINA 5)

Cancer | Lung Cancer, Non-Small Cell

France
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 3)

Hereditary Angioedema

United States
Gunkang Pharmaceuticals, Inc

Completed

Clinical Study to Evaluate the Efficacy and Safety of GNS-212-E in Bowel Preparation for Colonoscopy (GNS-212-E)

Colonoscopy | Bowel Preparation

Korea, Republic of
Johann Wolfgang Goethe University Hospital
CSL Behring; University of Milan; PharmaPart; Clinical trial center Rhine-Main; ZKI... and other collaborators

Completed

Berinert P Study of Subcutaneous Versus Intravenous Administration (PASSION)

Hereditary Angioedema

Germany
Stanley Jordan, MD
CSL Behring

Completed

Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection

Kidney Transplantation

United States
CSL Behring

Completed

C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)

Hereditary Angioedema

United States, Canada
Radboud University Medical Center

Completed

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia (VECTOR)

Inflammation | Endotoxemia | Multi Organ Dysfunction Syndrome

Netherlands
Cedars-Sinai Medical Center

Completed

C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI (C1INHDGF)

End Stage Renal Disease | Ischemic Reperfusion Injury | Kidney Failure | Delayed Graft Function

United States
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 2)

Hereditary Angioedema

United States
Shire

Completed

Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects

Hereditary Angioedema

United States
Michael Levy
ViroPharma

Completed

C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation

Neuromyelitis Optica

United States
Shire

Completed

C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

United States
Shire

Completed

Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects

Hereditary Angioedema (HAE)

United States
UMC Utrecht
Prothya Biosolutions

Terminated

Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture (CAESAR)

Sepsis | Inflammation | Trauma | Multiple Organ Dysfunction Syndrome

Netherlands
Shire

Completed

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

Hereditary Angioedema (HAE)

Spain, Israel, United States, Hungary, Germany, Canada, Romania
Shire

Completed

C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

United States
AO GENERIUM

Withdrawn

Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema

Hereditary Angioedema

Russian Federation
Cedars-Sinai Medical Center
OneLegacy Foundation

Completed

Berinert (C1INH) vs Placebo for DGF/IRI

Chronic Kidney Diseases | End Stage Renal Disease

United States
University Hospital, Basel, Switzerland
Pharming Technologies B.V.; Clinical Trial Unit, University Hospital Basel,...

Completed

Recombinant Human C1 Esterase Inhibitor in the Prevention of Contrast-induced Nephropathy in High-risk Subjects (PROTECT)

Acute Kidney Injury

Switzerland
Thomas Jefferson University

Completed

AMBU Bag Manual Ventilation vs. Transport Ventilator Mechanical Ventilation for Transport

Mechanical Ventilation | Point of Care Ultrasound | Oxygenation | Manual Ventilation | Cardiac Function Disturbance Postoperative

United States
Haaglanden Medical Centre
Takeda; Leiden University Medical Center

Recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) (CIAO@SAH)

Subarachnoid Hemorrhage, Aneurysmal

Netherlands
National Institute of Allergy and Infectious Diseases...

Completed

Phase 1 Study of the Safety, Reactogenicity, and Immunogenicity of AMA1-C1/ISA 720: Blood Stage Vaccine for Plasmodium Falciparum

Malaria

Australia
Mithra Pharmaceuticals

Completed

Safety and Efficacy Study of Antiviral Local Application to Treat High Grade Cervical Intraepithelial Lesions (CIN2/3) (Colvir-PhaseII)

Cervix Intraepithelial Neoplasia | Uterine Cervical Neoplasia

Belgium
Orion Corporation, Orion Pharma

Recruiting

A Phase 1/2, First-in-Human Study On ODM-212 In Subjects With Selected Advanced Solid Tumours (TEADES)

Solid Tumours

United States, Finland, France, United Kingdom, Spain, Switzerland
Shire
Halozyme Therapeutics

Completed

A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase

Hereditary Angioedema

United States
Shire

Completed

Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks

Hereditary Angioedema (HAE)

United States, Germany, Spain, Sweden
Prothya Biosolutions

Completed

Kinetics, Efficacy and Safety of C1-Esteraseremmer-N

Hereditary Angioedema Type I | Angioneurotic Edema

Netherlands

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