Search clinical trials for: Dose decrease

Total 7785 results

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AstraZeneca
Karolinska Institutet; CTC Clinical Trial Consultants AB

Terminated

AZD3427 Effects on Renal Perfusion in Heart Failure Patients With Reduced Ejection Fraction and Renal Impairment (Re-PERFUSE)

Renal Impairment | Heart Failure With Reduced Ejection Fraction (HFrEF)

Sweden
Hellenic Scientific Society for the Study of AIDS...
Gilead Sciences

Completed

Rapid Antiretroviral Treatment Initiation With BIC/FTC/TAF in HIV-infected People Who Inject Drugs (PWID) (BFTAFDU)

HIV Positive People Who Inject Drugs

Greece
Janssen Research & Development, LLC

Completed

A Study to Assess the Bioequivalence of the Metformin Component of the Fixed Dose Combination Tablet of Canagliflozin and Metformin Extended Release With Respect to Metformin XR Tablet Coadministered With Canagliflozin in Healthy Fed and Fasted Participants

Healthy

United States
Seoul National University Hospital

Terminated

High-dose Chemotherapy with Thiotepa, Busulfan, and Cyclophosphamide Followed by Autologous Stem Cell Transplantation in Central Nervous System Lymphoma

Central Nervous System Lymphoma

Korea, Republic of
Tonix Pharmaceuticals, Inc.

Withdrawn

Safety and Efficacy Study of TNX-102 SL in Participants With PTSD

PTSD

Kenya
Maria Liljefors
Karolinska University Hospital; Karolinska Institutet; Celgene

Completed

Lenalidomide and Gemcitabine as First-line Treatment in Patients With Pancreatic Cancer (LENAGEM)

Pancreatic Ductal Adenocarcinoma | Pancreatic Carcinoma Metastatic

Sweden
National Cancer Institute, Egypt

Completed

Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

Anesthesia

Egypt
ClinAmygate
Fayoum University Hospital; Misr University for Science and Technology; Al Safwa...

Completed

Triclosan-antibacterial Sutures Impact on the Incidence of Surgical Site Infection in Laparoscopic Surgeries.

Laparoscopic Surgery | Surgical Wound | Surgical Site Infection

Egypt
Wake Forest University Health Sciences

Terminated

Leukemia Stem Cell Detection in Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML)

United States
Octapharma

Completed

Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

Significant Bleeding Risk

Russian Federation, United States, Romania, Ukraine, Belarus, Bulgaria, Georgia, Germany, Moldova, Republic of, Poland, Spain
Menarini Group

Terminated

Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections (DRESS)

Surgical Site Infection

Italy
EMD Serono

Terminated

Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus

Advanced Solid Tumor

United States
Institute of Liver and Biliary Sciences, India

Completed

To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock

Cirrhosis With Septic Shock

India
Gruppo Italiano Terapie Innovative nei Linfomi

Completed

Comparison of HD Chemotherapy Followed by Auto-transplant and R-CHOP in High Risk Patients With DLBCL.

Diffuse Large B-Cell Lymphoma

Italy
Samsung Medical Center
Don-A Pharmaceutical, Seoul, South Korea

Unknown

Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis (STAMINA-MRI)

Stroke | Intracranial Atherosclerosis

Korea, Republic of
Newcastle-upon-Tyne Hospitals NHS Trust

Completed

Antithyroid Drug Treatment of Thyrotoxicosis in Young People

Paediatric Thyrotoxicosis

United Kingdom
Pfizer

Completed

Actual Use Trial of Ibuprofen 400 mg

Patient Compliance

United States
Shanghai Celgen Bio-Pharmaceutical Co.,Ltd

Unknown

Safety and Efficacy Study of Etanercept (Qiangke®) to Treat Moderate to Severe Plaque Psoriasis

Psoriasis | Plaque Psoriasis

China
Sanofi Pasteur, a Sanofi Company

Completed

Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Influenza Virus Vaccine (2012-2013 Formulation)

Influenza

United States
Genzyme, a Sanofi Company

Completed

Evaluation of Approved Weight-Based Dose Compared to Fixed Dose of Plerixafor in Patients With Non-Hodgkin's Lymphoma (NHL) Weighing Less Than 70 Kilograms

Non-Hodgkin's Lymphoma

Korea, Republic of, Taiwan, United States, Canada
Radboud University Medical Center

Completed

Ticagrelor and Adenosine

Healthy

Netherlands
Shandong Cancer Hospital and Institute

Unknown

TACE Combinated With Sorafenib in Treating Patients With Unresectable Hepatocellular Carcinoma

Carcinoma, Hepatocellular | PHENYTOIN/SORAFENIB [VA Drug Interaction]

China
Johnson & Johnson Consumer and Personal Products...

Completed

Pharmacokinetics of 3 Formulations of Ibuprofen Suppositories

Healthy

Ireland
PETHEMA Foundation

Completed

Bortezomib/Adriamycine/Melfalan/Prednisone (VAMP)/Thalidomide/Cyclophosphamide/Dexamethasone (TaCyDex) or Bortezomib/Melfalan/Prednisone (V-MP)/TaCyDex) in Refractary or Relapsed Multiple Myeloma (TaCyDexVMP7)

Multiple Myeloma

Spain
Kindai University

Completed

Study of Sorafenib In Combination With Low-dose 5-fluorouracil/Cisplatin (FP) Intraarterial Infusion Chemotherapy (SILIUS)

Hepatocellular Carcinoma

Japan
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Sirolimus and Cyclosporine in Kidney Transplant Recipients

Renal Transplantation
Sichuan University

Recruiting

High-Dose Gemcitabine, Busulfan, and Thiotepa Followed by ASCT in Primary Central Nervous System Lymphoma

Primary Central Nervous System Lymphoma (PCNSL)

China
Laboratorios Silanes S.A. de C.V.

Recruiting

Efficacy and Safety of the Fixed-dose Combination Atorvastatin/Fenofibrate vs Atorvastatin in Patients With T2D and DLP.

Dyslipidemia Associated With Type II Diabetes Mellitus

Mexico
Brigham and Women's Hospital
Massachusetts General Hospital; Washington University School of Medicine; National... and other collaborators

Terminated

Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)

Sepsis | Acute Respiratory Distress Syndrome

United States
The University of Hong Kong
Centers for Disease Control and Prevention

Completed

Immunogenicity of Alternative Annual Influenza Vaccination Strategies in Older Adults in Hong Kong (PIVOT)

Influenza, Human

China
University of North Carolina, Chapel Hill
Albert Einstein College of Medicine; Abbott; Doris Duke Charitable Foundation; Université...

Completed

The COMBAT HBV Feasibility Trial (COMBAT-HBV)

Hepatitis B | Vertical Transmission of Infectious Disease

Democratic Republic of the Congo
Professor Francois Venter
Bill and Melinda Gates Foundation

Active, not recruiting

Utilizing Private Pharmacies to Initiate High-risk Young Individuals on PrEP in South Africa (PPREPP-SA)

HIV Infection

South Africa
Diwakar Davar
Aculeus Therapeutics

Completed

Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC)

NSCLC | Metastatic Colorectal Carcinoma | Refractory Melanoma

United States
Merck Sharp & Dohme LLC

Completed

A Study of Doravirine and Islatravir as a Single Entity or Combination Therapy and the Effect of Food in Healthy Adult Participants (MK-8591A-055)

Healthy

United States
University of Waterloo
Sun Pharmaceutical Industries Limited

Completed

Improving Drop Instillation Comfort of a Cyclosporine A Solution

Dry Eye Disease

Canada
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Withdrawn

Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed Dyslipidemia (MILOS-Spain)

Mixed Dyslipidemia | Primary Hypercholesterolemia
Federico II University

Completed

Eplerenone Versus PDT: Comparative Study by OCTA

Central Serous Chorioretinopathy
University of Cincinnati

Completed

Study to Evaluate Safety and Efficacy of Early Calcineurin Inhibitor Withdrawal in Primary Renal Allografts

Primary Renal Allograft

United States
Juntendo University
Japan Heart Foundation

Completed

Azelnidipine Anti-Coronary Atherosclerotic Trial in Hypertensive Patients by Serial Volumetric IVUS Analysis(ALPS-J)

Hypertension | Coronary Atherosclerosis

Japan
The Netherlands Cancer Institute

Terminated

Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD

Breast Cancer

Netherlands
Cairo University

Unknown

Erector Spinae Block Versus Thoracic Paravertebral Block for Postoperative Pain Control After Open Nephrectomy

Pain, Postoperative
Jonsson Comprehensive Cancer Center
Pfizer

Completed

CP-675,206 (CTLA4-Blocking Monoclonal Antibody) Combined With Dendritic Cell Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed With Surgery

Melanoma (Skin)

United States
Acrotech Biopharma Inc.
Clinipace Worldwide; Beckloff Associates, Inc.; Kansas City Bioanalytical Laboratories

Completed

Safety & Efficacy Study High Dose Evomela Injection for MA Conditioning in MM Patients With Autologous Transplantation

Multiple Myeloma

United States
Eli Lilly and Company
Algorithme Pharma Inc; CoLucid Pharmaceuticals; Cognitive Research Corporation

Completed

The Effects of Lasmiditan on Simulated Driving Performance - Healthy Participants

Migraine

Canada
National Institute on Drug Abuse (NIDA)

Completed

Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management

Cocaine-Related Disorders | Opiate-Related Disorders

United States
University of Cincinnati
Sanofi

Withdrawn

Phase II Study Of Neoadjuvant Chemotherapy In Borderline Resectable Pancreatic Adenocarcinoma

Pancreatic Adenocarcinoma

United States
Merck Sharp & Dohme LLC

Completed

Phase IIB 2-Period Crossover Polysomnography Study in Participants With Primary Insomnia (MK-4305-006)

Primary Insomnia
Wex Pharmaceuticals Inc.
Premier Research Group plc

Terminated

The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From Chemotherapy Treatment (TTX-CINP-201)

Pain | Neuropathic Pain | Peripheral Neuropathy

United States
AstraZeneca

Completed

Brilinta Taiwan Post Approval Safety Study

Non ST-elevation Myocardial Infarction

Taiwan
Merck Sharp & Dohme LLC

Completed

A Long Term Safety Study of Suvorexant in Participants With Primary Insomnia (MK-4305-009 AM3)

Insomnia

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