Search clinical trials for: First in class

Total 457538 results

Yu xiaowei

Not yet recruiting

Obesity With Sperm Quality in Men With Fertility Need

Obesity | Visceral Fat | Sperm Quality | Sex Hormones
First Affiliated Hospital, Sun Yat-Sen University

Not yet recruiting

Multi-classifier System for Stratifying Stage III Papillary Renal Cell Carcinoma of Receiving Adjuvant Therapy

Papillary Renal Cell Carcinoma
Sun Yat-sen University
The First Affiliated Hospital of Anhui Medical University; Peking University... and other collaborators

Recruiting

PaCIFiC-CUP Classifies Cancer of Unknown Primary

Unknown Primary Tumors | DNA Methylation

China
Fujian Cancer Hospital
First Affiliated Hospital of Fujian Medical University; Fujian Provincial Hospital and other collaborators

Not yet recruiting

MRI Radiomics Combined With Pathomics on the Prediction of Molecular Classification and Prognosis of Endometrial Cancer

Endometrial Neoplasms

China
AceLink Therapeutics, Inc.
Tigermed Consulting Co., Ltd

Recruiting

Study of the Safety and Biologic Activity of AL01211 in Treatment Naive Males With Classic Fabry Disease

Fabry Disease

China
Akeso

Recruiting

To Evaluate the Efficacy and Safety of AK111 Injection in the Treatment of Moderate to Severe Plaque Psoriasis

Skin Diseases | Psoriasis

China
University of Cologne

Not yet recruiting

Pembrolizumab in First-Line Treatment of Advanced-Stage Classical Hodgkin Lymphoma (Pembro-FLASH)

Hodgkin Lymphoma

Germany
Akeso

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of AK120 in Subjects With Atopic Dermatitis

Atopic Dermatitis

China
Genmab

Recruiting

A First-in-human Trial of GEN3017 in Hodgkin Lymphoma and Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma | Classical Hodgkin Lymphoma

United States, Australia
First Affiliated Hospital Xi'an Jiaotong University
Shaanxi Provincial People's Hospital; Henan Provincial People's Hospital; 521... and other collaborators

Not yet recruiting

Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC) (CLASSIC)

Aortic Dissection

China
Shanghai Pulmonary Hospital, Shanghai, China
Zunyi Medical College; Ningbo HwaMei Hospital, Zhejiang, China; The First Affiliated...

Recruiting

Whole Slide Image for Predicting the Novel Grading System of Resected Lung Adenocarcinoma

Lung Adenocarcinoma | Whole Slide Image | Novel Grading System

China
AstraZeneca

Recruiting

Durvalumab and Tremelimumab as First Line Treatment in Participants With Advanced Hepatocellular Carcinoma (HCC) (SIERRA)

Advanced Hepatocellular Carcinoma

Korea, Republic of, Italy, Spain, Vietnam, Germany, France, Japan, United States, Hong Kong, Singapore
Huai'an No.1 People's Hospital
The First Affiliated Hospital with Nanjing Medical University; Nanjing University...

Recruiting

A Study of Breathing Sound-based Classification of Patients With Breathing Disorders

Apnea

China
RenJi Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

Application Circulating Tumor DNA Dynamic Monitoring in Clinical Treatment of Metastatic Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma

China
Centre Hospitalier Régional d'Orléans

Recruiting

Removal of Nasogastric Feeding Tube Post Extubation in ICU : a Prospective Randomized Trial (FIRST)

Deglutition Disorders | Intensive Care Unit Syndrome | Swallowing Disorder | Feeding or Eating Disorder

France
Chinese Academy of Sciences
Shanxi Province Cancer Hospital; Sun Yat-sen University; Henan Cancer Hospital; Peking University Cancer Hospital & Institute and other collaborators

Recruiting

Prediction of Peritoneal Metastasis for Gastric Cancer Based on Radiomics

Gastric Cancer | Peritoneal Metastases

China, Italy
Peking Union Medical College Hospital
Peking University First Hospital; Xiangya Hospital of Central South University and other collaborators

Not yet recruiting

Study of Early Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions

Endometrial Cancer | Adjuvant Radiotherapy | Molecular Classification
Merck Sharp & Dohme LLC

Recruiting

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

Hodgkin Lymphoma

Australia, Israel, Korea, Republic of, Spain, Poland, Sweden, United Kingdom, Turkey, China, United States, Brazil, Germany, Belgium, France, Switzerland, Canada, Czechia, Chile, Argentina
Phost'In Therapeutics

Recruiting

First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours (PhAST)

Glioblastoma Multiforme | Metastatic Cancer | Advanced Solid Tumor | Malignant Tumor

Italy, France
First Affiliated Hospital of Zhejiang University

Recruiting

Chinese Longitudinal and Systematic Study of Bioplar Disorder (CLASS-BD)

Major Depressive Disorder | Bipolar Disorder, Mixed | Affective; Disorder, Organic

China
BeiGene

Recruiting

Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader

Follicular Lymphoma | Waldenström Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Non-Hodgkin Lymphoma | B-cell Malignancy | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Richter's Transformation | DLBCL Unclassifiable

China
Janssen Research & Development, LLC

Recruiting

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease (DUET-CD)

Crohn's Disease

United States, Denmark, Belgium, Taiwan, Italy, Korea, Republic of, Germany, United Kingdom, Israel, Malaysia, Poland, Japan, New Zealand, Netherlands, China, Canada, France, Spain, Norway, Singapore, Croatia, Brazil, Switzerland, Aus... and more
Can-Fite BioPharma

Recruiting

Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis (LIVERATION)

Hepatocellular Carcinoma | Cirrhosis

United States, Bosnia and Herzegovina, Bulgaria, Israel, Moldova, Republic of, Poland, Romania, Serbia, Slovakia
RenJi Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

Safety of Laparoscopic Resection for Gastrointestinal Stromal Tumor on Unfavorable Anatomic Site of Stomach

Gastrointestinal Stromal Tumors

China
Ruijin Hospital
The First Affiliated Hospital of Nanchang University; Qilu Hospital of Shandong... and other collaborators

Recruiting

The Efficacy and Safety of ZR2 Versus R-miniCHOP in the Treatment of Unfit or Frail de Novo Diffuse Large B-cell Lymphoma Patients Aged Older Than or Equal to 70 Years

Diffuse Large B-Cell Lymphoma

China
Rigen Biotech
RenJi Hospital; Tianjin Medical University Cancer Institute and Hospital; Guangdong... and other collaborators

Recruiting

NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules

Thyroid Cancer | Thyroid Nodule

China
Institute of Hematology & Blood Diseases Hospital
Xian-Janssen Pharmaceutical Ltd.

Not yet recruiting

R-EPOCH in Combination With Ibrutinib for Patients With Classical RT of CLL (BDHRT001)

Richter Transformation

China
University of Cologne

Not yet recruiting

Pembrolizumab in Combination With Salvage Chemotherapy for First-relapsed or Refractory Classical Hodgkin Lymphoma (Pembro-CORE)

Classical Hodgkin Lymphoma

Germany
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Study on the Relationship Between Neutrophil-mediated Thrombocytopenia and the Condition and the Course of Disease in Patients With HFRS

Hemorrhagic Fever With Renal Syndrome

China
Gelmetix
Excelya

Recruiting

Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease (DXM gel)

Degenerative Disc Disease | Intervertebral Disc Degeneration | Discogenic Pain | Lumbar Disc Degeneration | Lumbar Disc Disease | Chronic Lower Back Pain | Lumbar Disc Pain

France
State Budgetary Healthcare Institution, National...

Recruiting

First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1) (HL-Russia-1)

Hodgkin Lymphoma, Adult

Russian Federation
Sun Yat-sen University

Recruiting

PD-1 Inhibitor or PD-1 Inhibitor Plus GVD for Relapsed/Refractory CHL

Classical Hodgkin Lymphoma | Refractory or Relapsed Classical Hodgkin Lymphoma

China
BeiGene

Recruiting

Tislelizumab Monotherapy Versus Salvage Chemotherapy for Relapsed/Refractory Classical Hodgkin Lymphoma

Classical Hodgkin Lymphoma

China
Medtronic Cardiac Rhythm and Heart Failure

Recruiting

Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure (ALLEVIATE-HF)

Heart Failure NYHA Class II | Heart Failure NYHA Class III

United States
Peking University
The First Affiliated Hospital with Nanjing Medical University; Zhejiang Cancer... and other collaborators

Recruiting

Laparoscopic Versus Open Lower Mediastinal Lymphadenectomy for Esophagogastric Junction Cancer

Gastric Cancer

China
Azienda Unità Sanitaria Locale Reggio Emilia

Recruiting

Adaptation and First Step Validation of the ICF Core Set for Vocational Rehabilitation for Cancer Survivors

Cancer Survivors

Italy
Technische Universität Dresden
Pfizer; Novartis Pharmaceuticals

Recruiting

Combination of Midostaurin and Gemtuzumab Ozogamicin in First-line Standard Therapy for Acute Myeloid Leukemia (MOSAIC) (MOSAIC)

Acute Myeloid Leukemia

Germany
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

The Safety of Totally Laparoscopic Versus Laparoscopy-Assisted Total Gastrectomy.

Gastric Cancer
National Cancer Institute (NCI)

Recruiting

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Colorectal Neoplasms | Advanced Breast Cancer | Advanced Solid Tumors | Malignant Peripheral Nerve Sheath Tumor | Metastatic Pancreatic Cancer | Pediatric Solid Tumor

United States
Henan Cancer Hospital

Recruiting

Camrelizumab Combined With AVD in the First-line Treatment for Patients With Advanced Classical Hodgkin's Lymphoma

Classical Hodgkin Lymphoma

China
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of a Sintilimab Plus ICE Regimen Versus ICE Regimen in Classic Hodgkin's Lymphoma Patients (cHL) Who Have Failed First-line Standard Chemotherapy

Classic Hodgkin's Lymphoma

China
Huashan Hospital
The First Affiliated Hospital with Nanjing Medical University; The First Affiliated... and other collaborators

Recruiting

Real World Study of Classic Infectious Disease

Brucelloses | Epidemic Hemorrhagic Fever | Kala-Azar

China
Russian Academy of Medical Sciences

Recruiting

Chicago Classification Normative Metrics in a Healthy Russian Cohort According to High-resolution Esophageal Manometry

Healthy

Russian Federation
RenJi Hospital
The First Affiliated Hospital with Nanjing Medical University; The First Affiliated... and other collaborators

Recruiting

Immunosuppressant Regimens for Living Fetuses Study

Recurrent Pregnancy Loss | Undifferentiated Connective Tissue Disease

China
West China Hospital
The First Affiliated Hospital with Nanjing Medical University; Fudan University and other collaborators

Recruiting

Laparoscopic D2 Distal Gastrectomy Following Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancers (CLASS-03a)

Surgery--Complications | Chemotherapy Effect | Cancer of Stomach | Complications, Postoperative

China
First Affiliated Hospital, Sun Yat-Sen University
Sun Yat-sen University; Third Affiliated Hospital, Sun Yat-Sen University; Sixth...

Not yet recruiting

A 6 microRNA Tool for Stratifying Stage II Colon Cancer of Receiving Adjuvant Chemotherapy

Colonic Neoplasms | Effects of Chemotherapy
Otsuka Pharmaceutical Development & Commercialization...

Recruiting

Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Agitation in Patients With Dementia of the Alzheimer's Type

United States, Spain, Hungary, Italy, Canada, Czechia, South Africa, Poland, Bulgaria, France
National Cancer Institute (NCI)

Active, not recruiting

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Ann Arbor Stage III Hodgkin Lymphoma | Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma | Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma | Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma | Ann Arbor Stage IV Hodgkin Lymphoma | Ann Arbor Stage IV... and other conditions

United States, Canada, Puerto Rico
National Cancer Institute (NCI)

Suspended

Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma

Recurrent Classic Hodgkin Lymphoma | Refractory Classic Hodgkin Lymphoma

United States
Imunon

Completed

Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma

United States, Taiwan, Korea, Republic of, China, Italy, Hong Kong, Thailand, Canada, Malaysia, Japan, Philippines

Search clinical trials for: First in class

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