Radiation Therapy in Treating Young Patients With Gliomas
24. července 2019 aktualizováno: Children's Oncology Group
A Phase II Study of Conformal Radiotherapy In Patients With Low-Grade Gliomas
RATIONALE: Specialized radiation therapy that delivers radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
PURPOSE: This phase II trial is studying how well radiation therapy works in treating young patients with gliomas.
Přehled studie
Postavení
Dokončeno
Intervence / Léčba
Detailní popis
OBJECTIVES:
Primary
- Determine the marginal-failure rate in young patients with low-grade gliomas treated with reduced-field conformal radiotherapy.
Secondary
- Determine the progression-free survival, event-free survival, and overall survival rates of young patients treated with this regimen.
- Determine quality of life of patients treated with this regimen.
- Correlate MIB-1 labeling index with progression-free survival and overall survival of these patients.
OUTLINE: This is a multicenter study.
Patients undergo reduced-field conformal radiotherapy 5 days a week for 6 weeks in the absence of disease progression or unacceptable toxicity.
Quality of life is assessed at baseline or 6 weeks after completion of study treatment and then at 2 and 5 years (closed as of 10/27/2010).
After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 2 years, and then annually thereafter.
Typ studie
Intervenční
Zápis (Aktuální)
92
Fáze
- Fáze 2
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní místa
-
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Queensland
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Brisbane, Queensland, Austrálie, 4029
- Royal Children's Hospital
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Western Australia
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Perth, Western Australia, Austrálie, 6001
- Princess Margaret Hospital for Children
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-
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Quebec, Kanada, G1V 4G2
- Centre Hospitalier Universitaire de Quebec
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British Columbia
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Vancouver, British Columbia, Kanada, V6H 3V4
- Children's & Women's Hospital of British Columbia
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Manitoba
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Winnipeg, Manitoba, Kanada, R3E 0V9
- CancerCare Manitoba
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Nova Scotia
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Halifax, Nova Scotia, Kanada, B3J 3G9
- IWK Health Centre
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Ontario
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Hamilton, Ontario, Kanada, L8N 3Z5
- McMaster Children's Hospital at Hamilton Health Sciences
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London, Ontario, Kanada, N6A 5W9
- Children's Hospital of Western Ontario
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Ottawa, Ontario, Kanada, K1H 8L1
- Children's Hospital of Eastern Ontario
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Toronto, Ontario, Kanada, M5G 1X8
- Hospital for Sick Children
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Quebec
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Montreal, Quebec, Kanada, H3T 1C5
- Hôpital Sainte Justine
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Saskatchewan
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Saskatoon, Saskatchewan, Kanada, S7N 4H4
- Saskatoon Cancer Centre at the University of Saskatchewan
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-
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Auckland, Nový Zéland, 1
- Starship Children's Health
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Christchurch, Nový Zéland, 8140
- Christchurch Hospital
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Wellington, Nový Zéland, 6002
- Wellington Children's Hospital
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Santurce, Portoriko, 00912
- San Jorge Children's Hospital
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Alabama
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Birmingham, Alabama, Spojené státy, 35294
- UAB Comprehensive Cancer Center
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Arizona
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Phoenix, Arizona, Spojené státy, 85016-7710
- Phoenix Children's Hospital
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Arkansas
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Little Rock, Arkansas, Spojené státy, 72205
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
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California
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Downey, California, Spojené státy, 90027
- Southern California Permanente Medical Group
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Loma Linda, California, Spojené státy, 92354
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
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Long Beach, California, Spojené státy, 90801
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
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Los Angeles, California, Spojené státy, 90095-1781
- Jonsson Comprehensive Cancer Center at UCLA
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Los Angeles, California, Spojené státy, 90027
- Childrens Hospital Los Angeles
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Los Angeles, California, Spojené státy, 90048-1865
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
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Madera, California, Spojené státy, 93638-8762
- Children's Hospital Central California
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Oakland, California, Spojené státy, 94609
- Children's Hospital and Research Center Oakland
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Orange, California, Spojené státy, 92868
- Children's Hospital of Orange County
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Sacramento, California, Spojené státy, 95817
- University of California Davis Cancer Center
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Sacramento, California, Spojené státy, 95825
- Kaiser Permanente Medical Center - Oakland
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San Diego, California, Spojené státy, 92123-4282
- Rady Children's Hospital - San Diego
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San Francisco, California, Spojené státy, 94115
- UCSF Helen Diller Family Comprehensive Cancer Center
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Colorado
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Aurora, Colorado, Spojené státy, 80045
- Children's Hospital Center for Cancer and Blood Disorders
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Denver, Colorado, Spojené státy, 80218
- Presbyterian - St. Luke's Medical Center
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Connecticut
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Hartford, Connecticut, Spojené státy, 06106
- Connecticut Children's Medical Center
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Delaware
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Wilmington, Delaware, Spojené státy, 19803
- Alfred I. DuPont Hospital for Children
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District of Columbia
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Washington, District of Columbia, Spojené státy, 20007
- Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
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Washington, District of Columbia, Spojené státy, 20307-5001
- Walter Reed Army Medical Center
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Florida
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Fort Myers, Florida, Spojené státy, 33901
- Lee Cancer Care of Lee Memorial Health System
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Hollywood, Florida, Spojené státy, 33021
- Memorial Cancer Institute at Memorial Regional Hospital
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Jacksonville, Florida, Spojené státy, 32207
- Nemours Children's Clinic
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Miami, Florida, Spojené státy, 33136
- University of Miami Sylvester Comprehensive Cancer Center - Miami
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Miami, Florida, Spojené státy, 33155
- Miami Children's Hospital
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Orlando, Florida, Spojené státy, 32803-1273
- Florida Hospital Cancer Institute at Florida Hospital Orlando
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Orlando, Florida, Spojené státy, 32806
- Nemours Children's Clinic - Orlando
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Orlando, Florida, Spojené státy, 32806
- M.D. Anderson Cancer Center at Orlando
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Pensacola, Florida, Spojené státy, 32504
- Sacred Heart Cancer Center at Sacred Heart Hospital
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Saint Petersburg, Florida, Spojené státy, 33701
- All Children's Hospital
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Tampa, Florida, Spojené státy, 33607
- St. Joseph's Cancer Institute at St. Joseph's Hospital
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West Palm Beach, Florida, Spojené státy, 33407
- Kaplan Cancer Center at St. Mary's Medical Center
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Georgia
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Atlanta, Georgia, Spojené státy, 30322
- AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
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Augusta, Georgia, Spojené státy, 30912-3730
- MBCCOP - Medical College of Georgia Cancer Center
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Hawaii
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Honolulu, Hawaii, Spojené státy, 96813
- Cancer Research Center of Hawaii
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Idaho
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Boise, Idaho, Spojené státy, 83712-6297
- Mountain States Tumor Institute at St. Luke's Regional Medical Center
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Illinois
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Chicago, Illinois, Spojené státy, 60637-1470
- University of Chicago Cancer Research Center
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Chicago, Illinois, Spojené státy, 60612-7243
- University of Illinois Cancer Center
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Oak Lawn, Illinois, Spojené státy, 60453
- Keyser Family Cancer Center at Advocate Hope Children's Hospital
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Park Ridge, Illinois, Spojené státy, 60068-1174
- Advocate Lutheran General Cancer Care Center
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Peoria, Illinois, Spojené státy, 61637
- Saint Jude Midwest Affiliate
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Springfield, Illinois, Spojené státy, 62794-9677
- Simmons Cooper Cancer Institute
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Indiana
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Indianapolis, Indiana, Spojené státy, 46202-5289
- Indiana University Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Spojené státy, 46260
- St. Vincent Indianapolis Hospital
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Iowa
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Iowa City, Iowa, Spojené státy, 52242-1002
- Holden Comprehensive Cancer Center at University of Iowa
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Kentucky
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Lexington, Kentucky, Spojené státy, 40536-0093
- Lucille P. Markey Cancer Center at University of Kentucky
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Louisville, Kentucky, Spojené státy, 40232
- Kosair Children's Hospital
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Louisiana
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Alexandria, Louisiana, Spojené státy, 71315-3198
- Tulane Cancer Center Office of Clinical Research
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Maryland
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Baltimore, Maryland, Spojené státy, 21215
- Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
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Michigan
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Detroit, Michigan, Spojené státy, 48201-1379
- Barbara Ann Karmanos Cancer Institute
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Grand Rapids, Michigan, Spojené státy, 49503-2560
- Butterworth Hospital at Spectrum Health
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Grosse Pointe Woods, Michigan, Spojené státy, 48236
- Van Elslander Cancer Center at St. John Hospital and Medical Center
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Kalamazoo, Michigan, Spojené státy, 49007-5381
- CCOP - Kalamazoo
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Lansing, Michigan, Spojené státy, 48910
- Breslin Cancer Center at Ingham Regional Medical Center
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Minnesota
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Minneapolis, Minnesota, Spojené státy, 55404
- Children's Hospitals and Clinics of Minnesota - Minneapolis
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Rochester, Minnesota, Spojené státy, 55905
- Mayo Clinic Cancer Center
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Mississippi
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Jackson, Mississippi, Spojené státy, 39216-4505
- University of Mississippi Cancer Clinic
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Missouri
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Kansas City, Missouri, Spojené státy, 64108
- Children's Mercy Hospital
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Saint Louis, Missouri, Spojené státy, 63104
- Cardinal Glennon Children's Hospital
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Saint Louis, Missouri, Spojené státy, 63110
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
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Nevada
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Las Vegas, Nevada, Spojené státy, 89109-2306
- CCOP - Nevada Cancer Research Foundation
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New Hampshire
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Lebanon, New Hampshire, Spojené státy, 03756-0002
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
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New Jersey
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Hackensack, New Jersey, Spojené státy, 07601
- Hackensack University Medical Center Cancer Center
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Morristown, New Jersey, Spojené státy, 07962
- Overlook Hospital
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New Brunswick, New Jersey, Spojené státy, 08903
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
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Paterson, New Jersey, Spojené státy, 07503
- St. Joseph's Hospital and Medical Center
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New Mexico
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Albuquerque, New Mexico, Spojené státy, 87131-5636
- University of New Mexico Cancer Center
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New York
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Bronx, New York, Spojené státy, 10461
- Albert Einstein Cancer Center at Albert Einstein College of Medicine
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Brooklyn, New York, Spojené státy, 11219
- Maimonides Cancer Center at Maimonides Medical Center
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Buffalo, New York, Spojené státy, 14263-0001
- Roswell Park Cancer Institute
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Mineola, New York, Spojené státy, 11501
- Winthrop University Hospital
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New York, New York, Spojené státy, 10065
- Memorial Sloan-Kettering Cancer Center
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New York, New York, Spojené státy, 10016
- NYU Cancer Institute at New York University Medical Center
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New York, New York, Spojené státy, 10032
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
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Rochester, New York, Spojené státy, 14642
- James P. Wilmot Cancer Center at University of Rochester Medical Center
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Stony Brook, New York, Spojené státy, 11794-9446
- Stony Brook University Cancer Center
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Syracuse, New York, Spojené státy, 13210
- SUNY Upstate Medical University Hospital
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Valhalla, New York, Spojené státy, 10595
- New York Medical College
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North Carolina
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Chapel Hill, North Carolina, Spojené státy, 27599-7295
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
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Charlotte, North Carolina, Spojené státy, 28232-2861
- Blumenthal Cancer Center at Carolinas Medical Center
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Durham, North Carolina, Spojené státy, 27710
- Duke Comprehensive Cancer Center
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Winston-Salem, North Carolina, Spojené státy, 27157-1096
- Wake Forest University Comprehensive Cancer Center
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Ohio
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Akron, Ohio, Spojené státy, 44308-1062
- Akron Children's Hospital
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Cincinnati, Ohio, Spojené státy, 45229-3039
- Cincinnati Children's Hospital Medical Center
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Cleveland, Ohio, Spojené státy, 44195
- Cleveland Clinic Taussig Cancer Center
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Cleveland, Ohio, Spojené státy, 44106-5000
- Rainbow Babies and Children's Hospital
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Columbus, Ohio, Spojené státy, 43205-2696
- Nationwide Children's Hospital
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Dayton, Ohio, Spojené státy, 45404-1815
- Dayton Children's - Dayton
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Toledo, Ohio, Spojené státy, 43614
- Medical University of Ohio Cancer Center
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Youngstown, Ohio, Spojené státy, 44501
- Tod Children's Hospital
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Oklahoma
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Oklahoma City, Oklahoma, Spojené státy, 73104
- Oklahoma University Cancer Institute
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Oregon
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Portland, Oregon, Spojené státy, 97239-3098
- Knight Cancer Institute at Oregon Health and Science University
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Portland, Oregon, Spojené státy, 97227
- Legacy Emanuel Hospital and Health Center and Children's Hospital
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Pennsylvania
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Hershey, Pennsylvania, Spojené státy, 17033-0850
- Penn State Children's Hospital
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Philadelphia, Pennsylvania, Spojené státy, 19134-1095
- St. Christopher's Hospital for Children
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Pittsburgh, Pennsylvania, Spojené státy, 15213
- Children's Hospital of Pittsburgh of UPMC
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Rhode Island
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Providence, Rhode Island, Spojené státy, 02903
- Rhode Island Hospital Comprehensive Cancer Center
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South Carolina
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Charleston, South Carolina, Spojené státy, 29425
- Hollings Cancer Center at Medical University of South Carolina
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Columbia, South Carolina, Spojené státy, 29203
- Palmetto Health South Carolina Cancer Center
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Greenville, South Carolina, Spojené státy, 29605
- Greenville Hospital Cancer Center
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South Dakota
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Sioux Falls, South Dakota, Spojené státy, 57117-5039
- Sanford Cancer Center at Sanford USD Medical Center
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Tennessee
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Knoxville, Tennessee, Spojené státy, 37901
- East Tennessee Children's Hospital
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Memphis, Tennessee, Spojené státy, 38105
- St. Jude Children's Research Hospital
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Texas
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Amarillo, Texas, Spojené státy, 79106
- Texas Tech University Health Sciences Center School of Medicine - Amarillo
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Corpus Christi, Texas, Spojené státy, 78411
- Driscoll Children's Hospital
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Dallas, Texas, Spojené státy, 75390
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
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Fort Worth, Texas, Spojené státy, 76104
- Cook Children's Medical Center - Fort Worth
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Houston, Texas, Spojené státy, 77030-4009
- M. D. Anderson Cancer Center at University of Texas
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Lubbock, Texas, Spojené státy, 79410
- Covenant Children's Hospital
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San Antonio, Texas, Spojené státy, 78229-3993
- Methodist Children's Hospital of South Texas
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San Antonio, Texas, Spojené státy, 78207
- University of Texas Health Science Center at San Antonio
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Temple, Texas, Spojené státy, 76508
- CCOP - Scott and White Hospital
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Utah
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Salt Lake City, Utah, Spojené státy, 84113-1100
- Primary Children's Medical Center
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Vermont
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Burlington, Vermont, Spojené státy, 05401
- Fletcher Allen Health Care - University Health Center Campus
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Virginia
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Falls Church, Virginia, Spojené státy, 22042-3300
- INOVA Fairfax Hospital
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Norfolk, Virginia, Spojené státy, 23507-1971
- Children's Hospital of The King's Daughters
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Roanoke, Virginia, Spojené státy, 24014
- Carilion Medical Center for Children at Roanoke Community Hospital
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Washington
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Seattle, Washington, Spojené státy, 98105
- Children's Hospital and Regional Medical Center - Seattle
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Spokane, Washington, Spojené státy, 99220-2555
- Providence Cancer Center at Sacred Heart Medical Center
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West Virginia
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Charleston, West Virginia, Spojené státy, 25302
- West Virginia University Health Sciences Center - Charleston
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Huntington, West Virginia, Spojené státy, 25701
- Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
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Morgantown, West Virginia, Spojené státy, 26506
- Mary Babb Randolph Cancer Center at West Virginia University Hospitals
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Wisconsin
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Green Bay, Wisconsin, Spojené státy, 54307-3508
- St. Vincent Hospital Regional Cancer Center
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Madison, Wisconsin, Spojené státy, 53792-6164
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
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Milwaukee, Wisconsin, Spojené státy, 53226
- Midwest Children's Cancer Center at Children's Hospital of Wisconsin
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-
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Geneva, Švýcarsko, 1205
- Swiss Pediatric Oncology Group Geneva
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Lausanne, Švýcarsko, 1011
- Swiss Pediatric Oncology Group Lausanne
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Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
3 roky až 20 let (Dítě, Dospělý)
Přijímá zdravé dobrovolníky
Ne
Pohlaví způsobilá ke studiu
Všechno
Popis
DISEASE CHARACTERISTICS:
Histologically confirmed* low-grade glioma, including any of the following:
- Juvenile pilocytic astrocytoma (JPA) or pleomorphic JPA
Diffuse astrocytoma, including any of the following subtypes:
- Fibrillary astrocytoma
- Gemistocytic astrocytoma
- Subependymal giant cell astrocytoma
- Pleomorphic xanthoastrocytoma
- Low-grade oligoastrocytoma
- Low-grade oligodendroglioma
- Low-grade glioma not otherwise specified NOTE: *Patients with chiasmatic lesions who have contiguous extension of tumor into other regions of the visual pathway by CT scan or MRI are eligible without histopathologic confirmation; repeat biopsy required for patients with recurrent tumors that enhance but whose initial tumor did not
- Measurable disease by radiography
Meets any of the following criteria:
Progressive nonresectable disease
- Any location in the brain
- Patients with a less than gross total resection are eligible provided they are symptomatic from their tumor OR the risk from neurologic impairment with progression is high enough to warrant immediate treatment
- Has undergone biopsy only
Must have received ≥ 1 course of prior chemotherapy (for patients < 10 years of age)
- Prior chemotherapy optional (for patients ≥ 10 years of age)
- No type-1 neurofibromatosis
- No evidence of leptomeningeal dissemination
PATIENT CHARACTERISTICS:
Age
- 3 to 20
Performance status
- ECOG 0-2 OR
- Karnofsky 50-100% (for patients > 16 years of age) OR
- Lansky 50-100% (for patients ≤ 16 years of age)
Life expectancy
- At least 1 year
Hematopoietic
- Absolute neutrophil count ≥ 1,000/mm^3
- Platelet count ≥ 100,000/mm^3 (transfusion independent)
- Hemoglobin ≥ 10.0 g/dL (transfusions allowed)
Hepatic
- Not specified
Renal
- Not specified
Other
- Not pregnant
- Negative pregnancy test
- Fertile patients must use effective contraception
- Not in status epilepticus, coma, or requiring assisted ventilation prior to study entry
- Patients with a seizure disorder are eligible provided they are on anticonvulsants AND disease is well controlled
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- See Disease Characteristics
- Recovered from prior chemotherapy
- No concurrent chemotherapy
Endocrine therapy
- Concurrent dexamethasone allowed provided patient has been on a stable dose for ≥ 2 weeks prior to study entry
- Concurrent dexamethasone allowed for symptoms of increased intracranial pressure
Radiotherapy
- No prior radiotherapy
Surgery
- See Disease Characteristics
Other
- No other concurrent anticancer therapy
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: N/A
- Intervenční model: Přiřazení jedné skupiny
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
|
Experimentální: Treatment (radiotherapy)
Patients undergo reduced-field conformal radiation therapy 5 days a week for 6 weeks in the absence of disease progression or unacceptable toxicity.
|
Undergo 3D-CRT Undergo proton radiation therapy Undergo IMRT
Ostatní jména:
|
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Marginal-failure Rate
Časové okno: Up to 5 years
|
Patients who do not recur as well as those with either central or distant recurrence would be treatment successes for this endpoint.
Monitoring will be based on a Bayesian rule, with binomial likelihood and a Beta on the parameter p, the proportion of failures that are marginal failures.
|
Up to 5 years
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Progression-free Survival Probability
Časové okno: 3 years
|
To estimate the progression-free survival rate for patients with recurrent, progressive or symptomatic low-grade gliomas after treatment with reduced field conformal radiation.
|
3 years
|
|
Event-free Survival Probability
Časové okno: 3 years
|
To estimate the event-free survival rate for patients with recurrent, progressive or symptomatic low-grade gliomas after treatment with reduced field conformal radiation
|
3 years
|
|
Overall Survival Probability
Časové okno: 3 years
|
To estimate the overall survival rate for patients with recurrent, progressive or symptomatic low-grade gliomas after treatment with reduced field conformal radiation.
|
3 years
|
|
Quality of Life (QOL)
Časové okno: Up to 5 years
|
QOL accessed using the Behavior Assessment System for Children (BASC), the Adaptive Behavior Assessment System (ABAS), the Behavior Rating Inventory of Executive Function (BRIEF), and the Symptom Checklist-90-R (SCL-90-R).
|
Up to 5 years
|
|
MIB-1 Labeling Index Using Immunohistochemical Techniques With the MIB-1 Antibody According to Established Methods
Časové okno: At baseline
|
The MIB-1 labeling Index will be calculated as the percentage of tumor nuclei that are immunoreactive.
|
At baseline
|
|
Correlation MIB-1 Labeling Index With PFS
Časové okno: Up to 10 years
|
The primary methods of analysis will be via stratified Cox regression
|
Up to 10 years
|
Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Spolupracovníci
Vyšetřovatelé
- Studijní židle: Edward G. Shaw, MD, Wake Forest University Health Sciences
- Studijní židle: Joel M. Cherlow, MD, Todd Cancer Institute at Long Beach Memorial Medical Center
Publikace a užitečné odkazy
Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia
1. listopadu 2006
Primární dokončení (Aktuální)
30. prosince 2013
Dokončení studie (Aktuální)
31. prosince 2018
Termíny zápisu do studia
První předloženo
12. října 2005
První předloženo, které splnilo kritéria kontroly kvality
12. října 2005
První zveřejněno (Odhad)
13. října 2005
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
7. srpna 2019
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
24. července 2019
Naposledy ověřeno
1. listopadu 2016
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
- Nemoci nervového systému
- Novotvary podle histologického typu
- Novotvary
- Novotvary podle místa
- Novotvary, žlázové a epiteliální
- Novotvary, neuroepiteliální
- Neuroektodermální nádory
- Novotvary, zárodečné buňky a embryonální
- Novotvary, nervová tkáň
- Gliom
- Novotvary nervového systému
- Novotvary centrálního nervového systému
Další identifikační čísla studie
- ACNS0221
- COG-ACNS0221 (Jiný identifikátor: Clinical Trials.gov)
- CIRB-05016 (Jiný identifikátor: Pediatric CIRB)
- CDR0000445095 (Jiný identifikátor: Clinical Trials.gov)
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .