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AsthmaVent - Effect of Mechanical Ventilation on Asthma Control in Children (AsthmaVent)

11. května 2016 aktualizováno: University of Aarhus

AsthmaVent is a multi-center study, investigating the association between indoor air quality and childhood asthma.

In Denmark, we spend more and more time indoors. Our houses are built airtight to save energy and are difficult to ventilate. We are thus more exposed to our indoor air than ever before. We know that indoor air contains many different components that can affect our airways inappropriately and particularly children with asthma, who have sensitive airways are sensitive to these components. The AsthmaVent project examines whether increased ventilation is able to improve the indoor environment to such an extent that the asthma disease control, for children with asthma and house dust mite allergy improves, resulting in need for less medication.

Previous studies have pointed towards a beneficial effect of mechanical ventilation, on both the indoor air quality and on children's health and quality of life. There is not currently a consensus in this area, as studies so far have not been large or good enough to confidently determine the effect.

This project is big and is designed so that it takes into account the sources of error seen in previous studies on the topic.

We include, over a 3-year period (2012-2014), a total of 80 children with asthma and house dust mite allergy aged 6-18 years, from pediatric departments in Aarhus, Odense, Kolding, Randers and Herning. They are divided into two groups, receiving either active ventilation or placebo ventilation, meaning a non-functioning ventilation system that just recirculates the air in the room. Ventilation systems are installed in the fall and winter and ventilate the child's bedroom during 9 months. Indoor air quality and asthma control are assessed every 3 months, both at home visits were air quality and allergen levels of house dust mites are studies and at visits to the outpatient clinics with control of asthma parameters and quality of life.

The project involves collaboration between several institutions with an interest in indoor air quality in relation to allergies and asthma and with great expertise in the field.The project was initiated by CISBO (Centre for Indoor Environment and Health in Dwellings), a center consisting of several institutions in Denmark dealing with indoor environment: Department of Public Health at Aarhus University and University of Copenhagen, Danish Building Research Institute and the Technical University of Denmark.

Since asthma is the most common chronic childhood disease in Denmark and since the development of allergies and asthma has high social and personal costs, it is important for both society and the individual family, to find out whether simply improving the indoor air quality by increased ventilation can lead to an improvement in asthma disease control.

Přehled studie

Postavení

Dokončeno

Podmínky

Intervence / Léčba

Detailní popis

The aim of the project is to investigate whether increased ventilation is able to improve the indoor air quality and thereby asthma disease control for children with asthma and house dust mite allergy.

Hypotheses:

  1. An increased ventilation in the home will reduce the need for inhaled steroids in children with house dust mite allergy and asthma.
  2. An increased ventilation in the home will improve the quality of life in children with house dust mite allergy and asthma.
  3. An increased ventilation in the home will improve the indoor environment and thus improve asthma disease control in children with house dust mite allergy and asthma.

Materials and methods: The study is a randomized double-blind placebo-controlled intervention study. The intervention is balanced mechanical ventilation in the bedroom of children with asthma and house dust mite allergy during 9-months.

Population: Over 3 year period (2012-2014) 80 families with asthmatic children aged 6-18 years will be included from out-patient clinics at the children's department of the University Hospitals of Aarhus and Odense and regional hospitals in Kolding, Randers and Herning. Families will also be included from private pediatric clinics in Aarhus.

Randomization: After inclusion children are randomized to either active ventilation or placebo ventilation. Randomization is done in blocks of 4 by center.

Intervention: The ventilation units Type DUPLEX 370 EC4.D and DUPLEX 370 are installed during the fall and run continuously for 9 months. The ventilation system is placed outside the house and provides filtered conditioned air to the child's bedroom, through insulated pipes mounted in a window opening. The window opening was built specifically for this purpose in form of a thermo plate replacing the window glass. The unit provides the bedroom with at least 2-3 air changes per hour. The placebo unit (DUPLEX 370) is a completely similar installation which only recirculates the air in the room instead of replacing it. We recommend all parents to wash the duvet and pillow every 3 months.

Data collection:

Data on the children's health is collected every 3 months when the families visit the outpatient clinics. The children are seen by specialist doctors.

At home visits, also every 3 months, data concerning the indoor air quality is collected.

Typ studie

Intervenční

Zápis (Aktuální)

46

Fáze

  • Nelze použít

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

  • Dánsko
    • Region Hovedstaden
      • Herlev, Region Hovedstaden, Dánsko, 2730
        • Børneafdelingen Herlev Hospital
    • Region Midt
      • Aarhus, Region Midt, Dánsko, 8200
        • Childrens Department, Aarhus University Hospital
      • Herning, Region Midt, Dánsko, 7400
        • Childrens Department, Herning Hospital
      • Randers, Region Midt, Dánsko, 8930
        • Childrens DEpartment, Randers Hospital
    • Region Nordsjælland
      • Hillerød, Region Nordsjælland, Dánsko, 3400
        • Childrens Department, Hillerød hospital
    • Region Syddanmark
      • Kolding, Region Syddanmark, Dánsko, 6000
        • Childrens Department, Kolding Hospital
      • Odense, Region Syddanmark, Dánsko, 5000
        • H.C. Andersens Children Hospital, Odense University Hospital

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

5 let až 18 let (Dítě, Dospělý)

Přijímá zdravé dobrovolníky

Ne

Pohlaví způsobilá ke studiu

Všechno

Popis

Inclusion Criteria:

  • Doctors diagnosed asthma
  • Need of inhaled steroid titrated down to at least 400 microg/day of Budesonide or equivalent dose of other corticosteroid
  • Skin prick test >/= 3 mm or specific IgE >/= 0,7 kU/l to house dust mites (Derm. Pteronyssinus and/or Derm. Farinae)
  • more than 500 nanog/gr dust of house dust mite allergen in the childs mattress.
  • Living in a one-family house and will allow changes of the house during the intervention period.
  • Capable of giving informed consent.

Exclusion Criteria:

  • Other clinically relevant allergies to tree pollen or animals present in the house.
  • Other diseases or treatments, as for example immunotherapy, which could influence the results.

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

  • Primární účel: Léčba
  • Přidělení: Randomizované
  • Intervenční model: Paralelní přiřazení
  • Maskování: Čtyřnásobek

Zbraně a zásahy

Skupina účastníků / Arm
Intervence / Léčba
Aktivní komparátor: Ventilation
Increased ventilation in the childs bedroom to at least 2-3 air changes pr hour.
Přístroj: Ventilation
The ventilation system is placed outside the house and provides filtered conditioned air to the child's bedroom, through insulated pipes mounted in a window opening. The window opening was built specifically for this purpose in form of a thermo plate replacing the window glass. The unit provides the bedroom with at least 2-3 air changes per hour
Ostatní jména:
  • Ventilation units Type DUPLEX 370 EC4.D
Komparátor placeba: Placebo ventilation
Ventilation system that recirculates the air in the childs bedroom
Přístroj: Placebo Ventilation
The placebo unit (DUPLEX 370) is a completely similar installation to the active ventilation unit, but it only recirculates the air in the room instead of replacing it with fresh conditioned air.
Ostatní jména:
  • Placebo ventilation unit type DUPLEX 370

Co je měření studie?

Primární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
Changes in dose of inhaled corticosteroid
Časové okno: Baseline, 3 months, 6 months and 9 months
Measured in micrograms of a specific inhaled corticosteroid
Baseline, 3 months, 6 months and 9 months
Changes in particle concentration in child bedroom
Časové okno: baseline, 3 months, 6 months and 9 months
Measured as particles pr. m3
baseline, 3 months, 6 months and 9 months

Sekundární výstupní opatření

Měření výsledku
Popis opatření
Časové okno
FEV1
Časové okno: Baseline, 3,6 and 9 months
Forced Expiratory Volume after 1 second
Baseline, 3,6 and 9 months
FeNO
Časové okno: Baseline, 3,6 and 9 months
Forced Expiratory Nitric Oxide
Baseline, 3,6 and 9 months
Quality of Life
Časové okno: Baseline, 3,6 and 9 months
Pediatric Asthma Quality of Life Questionaire
Baseline, 3,6 and 9 months
Standard Skin-prick-test and Specific IgE- phadiatop
Časové okno: Baseline and 9 months
Reduction in diameter of skin-prick-test for standard inhalant allergens and reduction in specific IgE for standard inhalant allergens measured in kU/l.
Baseline and 9 months
Asthma Symptoms
Časové okno: During 14 days at baseline, 3, 6 and 9 months
Assessed from a Symptom score scheme
During 14 days at baseline, 3, 6 and 9 months
Peakflow variability
Časové okno: Baseline, 3, 6 and 9 months
Baseline, 3, 6 and 9 months
Ventilation rate
Časové okno: Baseline, 3, 6 and 9 months
Ventilation rate in the childs bedroom and in the Whole house
Baseline, 3, 6 and 9 months
Physical conditions in the child bedroom and whole house
Časové okno: baseline, 3 6 and 9 months
Changes in temperature and humidity
baseline, 3 6 and 9 months
Allergens in child mattress and airborne in child bedroom
Časové okno: baseline, 3, 6 and 9 months
Reduction in allergen levels.
baseline, 3, 6 and 9 months

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

University of Aarhus

Vyšetřovatelé

  • Ředitel studie: Torben Sigsgaard, Professor, Aarhus University, Department of Public Health, Section for Environment, Occupation and Health
  • Vrchní vyšetřovatel: Nina V Hogaard, MD, Aarhus University, Dept. of Public Health, Section for Environment, Occupation and Health

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia

1. srpna 2012

Primární dokončení (Aktuální)

1. února 2016

Dokončení studie (Aktuální)

1. února 2016

Termíny zápisu do studia

První předloženo

19. února 2014

První předloženo, které splnilo kritéria kontroly kvality

19. února 2014

První zveřejněno (Odhad)

21. února 2014

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Odhad)

12. května 2016

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

11. května 2016

Naposledy ověřeno

1. května 2016

Více informací

Termíny související s touto studií

Klíčová slova

Další relevantní podmínky MeSH

Další identifikační čísla studie

  • AstmaVen - 1101

Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .

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