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Højdosis interferon alfa til behandling af patienter med trin II eller trin III melanom

13. juni 2023 opdateret af: ECOG-ACRIN Cancer Research Group

Fase III randomiseret undersøgelse af fire ugers højdosis interferon Alfa-2b i trin T2bN0, T3a-bN0, T4a-bN0 og T1-4, N1a,2a (mikroskopisk) melanom

RATIONALE: Interferon alfa kan forstyrre væksten af kræftceller. Det vides endnu ikke, om behandling med interferon alfa er mere effektiv end observation alene for stadium II eller stadium III melanom, der er blevet fuldstændig fjernet kirurgisk.

FORMÅL: Dette randomiserede fase III-forsøg studerer højdosis interferon alfa for at se, hvor godt det virker sammenlignet med observation kun ved behandling af patienter med stadium II eller stadium III melanom, der er blevet fuldstændig fjernet ved kirurgi.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Melanom (hud)

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primært mål:

Sammenlign effekten af højdosis interferon alfa-2b-behandling på den tilbagefaldsfrie overlevelse af patienter med fase II eller III resekeret malignt melanom.

Sekundære mål:

Sammenlign effekten af dette behandlingsregime på den samlede overlevelse af disse patienter.
Vurder toksiciteten af denne behandling hos disse patienter.
Sammenlign behandlingens effekt på livskvaliteten.

OVERSIGT: Dette er en randomiseret undersøgelse. Patienterne er stratificeret efter patologisk lymfeknudestatus (kendt vs ukendt), lymfeknudestadieprocedurer (vagtpostlymfeknudeprocedure vs. elektiv lymfeknudedissektion vs. ingen lymfadenektomi), Breslow-dybde (<= 1,0 mm vs. 1,01-2,0 mm vs. 2,01-4,0 mm vs > 4,0 mm), ulceration af den primære læsion (ja vs. nej vs. ukendt), og sygdomsstadiet (lymfeknudepositiv [N1, N2a] vs. lymfeknudenegativ [N0]). Patienterne randomiseres i en af to behandlingsarme i forholdet 1:1.

Arm I (observation): Patienter gennemgår observation i 4 uger.
Arm II (Interferon Alfa-2b): Patienter får højdosis interferon alfa-2b intravenøst (IV) over 20 minutter dagligt i 5 på hinanden følgende dage. Behandlingen gentages ugentligt i 4 uger i fravær af uacceptabel toksicitet.

Livskvalitet vurderes før behandling, på dag 22, hver 3. måned i 2 år og derefter hver 6. måned i 3 år.

Patienterne følges hver 3. måned i 2 år, hver 6. måned i 3 år, og derefter årligt derefter indtil 15 år efter randomisering.

PROJEKTERET TILSLUTNING: I alt 1.420 patienter vil blive akkumuleret til denne undersøgelse over 5 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1150

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Australien
- New South Wales
  - Westmead, New South Wales, Australien, 2145
    - Westmead Institute for Cancer Research at Westmead Hospital
Canada
- Alberta
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute at University of Alberta
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - British Columbia Cancer Agency - Centre for the Southern Interior
  - Surrey, British Columbia, Canada, V3V 1Z2
    - BCCA - Fraser Valley Cancer Centre
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - British Columbia Cancer Agency - Vancouver Cancer Centre
  - Victoria, British Columbia, Canada, V8R 6V5
    - British Columbia Cancer Agency - Vancouver Island Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - Nova Scotia Cancer Centre
- Ontario
  - Barrie, Ontario, Canada, L4M 6M2
    - Royal Victoria Hospital of Barrie
  - Hamilton, Ontario, Canada, L8V 5C2
    - Margaret and Charles Juravinski Cancer Centre
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program at London Health Sciences Centre
  - Oshawa, Ontario, Canada, L1G 2B9
    - R. S. McLaughlin Durham Regional Cancer Centre at Lakeridge Health Oshawa
  - St. Catharines, Ontario, Canada, L2R 7C6
    - St. Catharines General Hospital at Niagara Health System
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Hospital
  - Toronto, Ontario, Canada, M4N 3M5
    - Edmond Odette Cancer Centre at Sunnybrook
  - Toronto, Ontario, Canada, M9C 1A5
    - Trillium Health Centre - Mississauga Site
  - Windsor, Ontario, Canada, N8W 2X3
    - Windsor Regional Cancer Centre at Windsor Regional Hospital
- Quebec
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill Cancer Centre at McGill University
  - Montreal, Quebec, Canada, H2L 4M1
    - Hopital Notre-Dame du CHUM
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM - Hotel Dieu Hospital
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre at Pasqua Hospital
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35294
    - UAB Comprehensive Cancer Center
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
- Arizona
  - Tucson, Arizona, Forenede Stater, 85724-5024
    - Arizona Cancer Center at University of Arizona Health Sciences Center
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- California
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente - Deer Valley
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Comprehensive Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Peninsula Medical Center
  - Downey, California, Forenede Stater, 90027
    - Southern California Permanente Medical Group
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente - Fremont
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Institute at Marin General Hospital
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center - Hayward
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Palo Alto, California, Forenede Stater, 94304
    - Veterans Affairs Medical Center - Palo Alto
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Center at Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Cancer center
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, Forenede Stater, 94118
    - California Pacific Medical Center - California Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Rafael, California, Forenede Stater, 94903
    - Sutter Health - Western Division Cancer Research Group
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara Kiely Campus
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stanford, California, Forenede Stater, 94305-5824
    - Stanford Cancer Center
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - St. Anthony Central Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente - Denver
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Grand Junction, Colorado, Forenede Stater, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente - Lafayette
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Hope Cancer Care Center at Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary - Corwin Regional Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Danbury, Connecticut, Forenede Stater, 06810
    - Praxair Cancer Center at Danbury Hospital
  - Hartford, Connecticut, Forenede Stater, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, Forenede Stater, 06904
    - Carl and Dorothy Bennett Cancer Center at Stamford Hospital
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Tunnell Cancer Center at Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - CCOP - Christiana Care Health Services
- Florida
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Herbert D. Kerman Regional Oncology Center - Daytona Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist Cancer Institute - Jacksonville
  - Jupiter, Florida, Forenede Stater, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Sylvester Comprehensive Cancer Center - Miami
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Cancer Center at Sacred Heart Hospital
  - Pensacola, Florida, Forenede Stater, 32514
    - West Florida Cancer Institute at West Florida Hospital - Pensacola
  - Saint Petersburg, Florida, Forenede Stater, 33701
    - All Children's Hospital
  - Sarasota, Florida, Forenede Stater, 34236
    - Florida Cancer Specialists - Sarasota Downtown
  - West Palm Beach, Florida, Forenede Stater, 33407
    - Kaplan Cancer Center at St. Mary's Medical Center
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30322
    - Winship Cancer Institute of Emory University
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342-1611
    - Northside Hospital Cancer Center
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342
    - CCOP - Atlanta Regional
  - Atlanta, Georgia, Forenede Stater, 30322
    - AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
  - Augusta, Georgia, Forenede Stater, 30912
    - MBCCOP - Medical College of Georgia Cancer Center
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B. Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Marietta, Georgia, Forenede Stater, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274-2600
    - Southern Regional Medical Center
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Cancer Center - Medical Oncology
  - Savannah, Georgia, Forenede Stater, 31405
    - Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente - Moanalua Medical Center and Clinic
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Cancer Care Center
  - Berwyn, Illinois, Forenede Stater, 60402
    - Hematology Oncology Associates of Illinois - Berwyn
  - Chicago, Illinois, Forenede Stater, 60611-3013
    - Robert H. Lurie Comprehensive Cancer Center at Northwestern University
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forenede Stater, 60657
    - Saint Joseph Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Evanston, Illinois, Forenede Stater, 60201-1781
    - Evanston Hospital
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Cancer Care Center at Ingalls Memorial Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - Kellogg Cancer Care Center
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Hinsdale Hematology Oncology Associates
  - Joliet, Illinois, Forenede Stater, 60432
    - Midwest Center for Hematology/Oncology
  - Libertyville, Illinois, Forenede Stater, 60048
    - North Shore Oncology and Hematology Associates, Limited - Libertyville
  - Naperville, Illinois, Forenede Stater, 60563
    - La Grange Oncology Associates - Geneva
  - Niles, Illinois, Forenede Stater, 60714
    - Cancer Care and Hematology Specialists of Chicagoland - Niles
  - Rockford, Illinois, Forenede Stater, 61104-2315
    - Swedish-American Regional Cancer Center
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates - Skokie
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic, LLC
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology-Oncology, PC - Elkhart
  - Indianapolis, Indiana, Forenede Stater, 46202-5289
    - Indiana University Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - William N. Wishard Memorial Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Howard Community Hospital
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - La Porte, Indiana, Forenede Stater, 46350
    - Michiana Hematology Oncology PC - La Porte
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Michiana Hematology-Oncology, PC - South Bend
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Saint Joseph Regional Medical Center
  - Muncie, Indiana, Forenede Stater, 47303-3499
    - Cancer Center at Ball Memorial Hospital
  - Muncie, Indiana, Forenede Stater, 47303
    - Medical Consultants, PC at Ball Memorial Cancer Center
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC - Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital & Health Care Services
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, PC
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Regional Cancer Center at Mercy Medical Center
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates - West Des Moines
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Medical Center - West Campus
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol Hospital
  - Ottumwa, Iowa, Forenede Stater, 52501
    - McCreery Cancer Center at Ottumwa Regional
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates, LLP
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - Mercy Medical Center - Sioux City
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Cancer Treatment Center
- Kansas
  - Anthony, Kansas, Forenede Stater, 67003
    - Hospital District Sixth of Harper County
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas, PA - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas, PA - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, PA - El Dorado
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas, PA - Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas, PA - Liberal
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas, PA - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's Hospital - South
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas, PA - Parsons
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas, PA - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas, PA - Salina
  - Salina, Kansas, Forenede Stater, 67401
    - Tammy Walker Cancer Center at Salina Regional Health Center
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - Shawnee Mission Medical Center
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton-O'Neil Cancer Center
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas, PA - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas, PA - Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas, PA - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates in Womens Health, PA - North Review
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas, PA - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - Cancer Care at Our Lady of Bellefonte Hospital
  - Louisville, Kentucky, Forenede Stater, 40215
    - Drs. Carrol, Sheth, Raghavan
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71315-3198
    - Tulane Cancer Center Office of Clinical Research
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center - Bluebonnet
  - Monroe, Louisiana, Forenede Stater, 71210
    - Louisiana State University Health Sciences Center - Monroe
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
  - Shreveport, Louisiana, Forenede Stater, 71130-3932
    - Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- Maine
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Center for Cancer Medicine and Blood Disorders - Scarborough
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - DeCesaris Cancer Institute at Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center Cancer Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital Cancer Program at Union Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts-NEMC Cancer Center
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Dearborn, Michigan, Forenede Stater, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48201-1379
    - Barbara Ann Karmanos Cancer Institute
  - Escanaba, Michigan, Forenede Stater, 49431
    - Green Bay Oncology, Limited - Escanaba
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Dickinson County Healthcare System
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Memorial Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - West Michigan Cancer Center
  - Lambertville, Michigan, Forenede Stater, 48144
    - Haematology-Oncology Associates of Ohio and Michigan, PC
  - Lansing, Michigan, Forenede Stater, 48912-1811
    - Sparrow Regional Cancer Center
  - Livonia, Michigan, Forenede Stater, 48154
    - St. Mary Mercy Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital - Monroe
  - Niles, Michigan, Forenede Stater, 49120
    - Michiana Hematology Oncology PC - Niles
  - Pontiac, Michigan, Forenede Stater, 48341-2985
    - St. Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Mercy Regional Cancer Center at Mercy Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute at Saint Mary's - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeside Cancer Specialists, PLLC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Regional Cancer Care Center - St. Joseph
  - Warren, Michigan, Forenede Stater, 48093
    - St. John Macomb Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Bemidji
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805-1983
    - Duluth Clinic Cancer Center - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller - Dwan Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - St. Luke's Hospital Cancer Care Center
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Fergus Falls Medical Group, PA
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology, PA - Maplewood
  - Maplewood, Minnesota, Forenede Stater, 55109
    - HealthEast Cancer Care at St. John's Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center - Minneapolis
  - Robbinsdale, Minnesota, Forenede Stater, 55422-2900
    - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Cancer Center
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital Cancer Care Center
  - Shakopee, Minnesota, Forenede Stater, 55379
    - St. Francis Cancer Center at St. Francis Medical Center
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Willmar Cancer Center at Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology, PA - Woodbury
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216-4505
    - University of Mississippi Cancer Clinic
- Missouri
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Kansas City, Missouri, Forenede Stater, 64108
    - Children's Mercy Hospital
  - Kansas City, Missouri, Forenede Stater, 64131
    - CCOP - Kansas City
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center - Hospital Hill
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Cancer Institute at Saint Luke's Hospital
  - Kansas City, Missouri, Forenede Stater, 64114
    - St. Joseph Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology Oncology Associates, Incorporated
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Hospital
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology, Incorporated
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Arch Medical Services, Incorporated at Center for Cancer Care and Research
  - Springfield, Missouri, Forenede Stater, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, Forenede Stater, 59101
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59107-7000
    - Billings Clinic - Downtown
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Cancer Center
  - Butte, Montana, Forenede Stater, 59701
    - St. James Healthcare Cancer Care
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic - Main Facility
  - Great Falls, Montana, Forenede Stater, 59405-5309
    - Big Sky Oncology
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Cancer Institute at Benefis Healthcare
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology at KRMC
  - Missoula, Montana, Forenede Stater, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, Forenede Stater, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Cancer Resource Center - Lincoln
  - Omaha, Nebraska, Forenede Stater, 68198-6805
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegant Health Cancer Center at Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131-2197
    - Creighton University Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756-0002
    - Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center at Catholic Medical Center
- New Jersey
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center Cancer Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - CCOP - Northern New Jersey
  - Hamilton, New Jersey, Forenede Stater, 08690
    - Cancer Institute of New Jersey at Hamilton
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - Sparta, New Jersey, Forenede Stater, 07871
    - Frederick R. and Betty M. Smith Cancer Treatment Center
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87131-5636
    - University of New Mexico Cancer Center
- New York
  - East Syracuse, New York, Forenede Stater, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
  - Glens Falls, New York, Forenede Stater, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - Lake Success, New York, Forenede Stater, 11042
    - Monter Cancer Center of the North Shore-LIJ Health System
  - Manhasset, New York, Forenede Stater, 11030
    - CCOP - North Shore University Hospital
  - Manhasset, New York, Forenede Stater, 11030
    - Don Monti Comprehensive Cancer Center at North Shore University Hospital
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - Stony Brook, New York, Forenede Stater, 11794-9446
    - Stony Brook University Cancer Center
  - Syracuse, New York, Forenede Stater, 13210
    - SUNY Upstate Medical University Hospital
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203-5400
    - Randolph Hospital
  - Charlotte, North Carolina, Forenede Stater, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28233-3549
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke Comprehensive Cancer Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, Forenede Stater, 27403-1198
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, Forenede Stater, 27834
    - Leo W. Jenkins Cancer Center at ECU Medical School
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Cancer Center
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58122
    - MeritCare Broadway
- Ohio
  - Akron, Ohio, Forenede Stater, 44309-2090
    - Summa Center for Cancer Care at Akron City Hospital
  - Akron, Ohio, Forenede Stater, 44308-1062
    - Akron Children's Hospital
  - Barberton, Ohio, Forenede Stater, 44203
    - Barberton Citizens Hospital
  - Bellefontaine, Ohio, Forenede Stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Wood County Oncology Center
  - Canton, Ohio, Forenede Stater, 44710-1799
    - Aultman Cancer Center at Aultman Hospital
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45267
    - Charles M. Barrett Cancer Center at University Hospital
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Christ Hospital Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44106-5065
    - Case Comprehensive Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Cancer Care Center at MetroHealth Medical Center
  - Clyde, Ohio, Forenede Stater, 43410
    - North Coast Cancer Care - Clyde
  - Columbus, Ohio, Forenede Stater, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health - West Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center Cancer Care
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, Forenede Stater, 43210-1240
    - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45420
    - CCOP - Dayton
  - Dayton, Ohio, Forenede Stater, 45404
    - Dayton Children's - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Community Cancer Center
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Medical Associates
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - St. Luke's Hospital
  - Maumee, Ohio, Forenede Stater, 43537-1839
    - Northwest Ohio Oncology Center
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic - Oregon
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital Cancer Center
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43606
    - Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - Medical University of Ohio Cancer Center
  - Toledo, Ohio, Forenede Stater, 43617
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic, Incorporated - Main Clinic
  - Toledo, Ohio, Forenede Stater, 43623
    - St. Anne Mercy Hospital
  - Troy, Ohio, Forenede Stater, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Mount Carmel St. Ann's Cancer Center
  - Wilmington, Ohio, Forenede Stater, 45177
    - Clinton Memorial Hospital
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cleo Craig Cancer Research Clinic
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Oklahoma University Cancer Institute
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates - Mercy Campus
- Oregon
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forenede Stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Northwest Cancer Specialists at Rose Quarter Cancer Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital & Comprehensive Cancer Center
  - Portland, Oregon, Forenede Stater, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center and Children's Hospital
  - Salem, Oregon, Forenede Stater, 97309-5014
    - Salem Hospital Regional Cancer Care Services
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - St. Luke's Cancer Network at St. Luke's Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822-0001
    - Geisinger Cancer Institute at Geisinger Health
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Hazleton Cancer Center
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Children's Hospital
  - Lancaster, Pennsylvania, Forenede Stater, 17604
    - Lancaster General Hospital
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104-4283
    - Abramson Cancer Center of the University of Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19134-1095
    - St. Christopher's Hospital for Children
  - Philadelphia, Pennsylvania, Forenede Stater, 19107-5541
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC Cancer Centers
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Reading, Pennsylvania, Forenede Stater, 19612-6052
    - McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Cancer Center at Guthrie Clinic Sayre
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Hematology and Oncology Associates of Northeastern Pennsylvania
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group - Scenery Park
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - Susquehanna Cancer Center at Divine Providence Hospital
  - York, Pennsylvania, Forenede Stater, 17405
    - York Cancer Center at Apple Hill Medical Center
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center, PC
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5039
    - Sanford Cancer Center at Sanford USD Medical Center
- Tennessee
  - Kingsport, Tennessee, Forenede Stater, 37662
    - Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37901
    - East Tennessee Children's Hospital
  - Knoxville, Tennessee, Forenede Stater, 37909
    - Center for Biomedical Research
  - Nashville, Tennessee, Forenede Stater, 37232-6838
    - Vanderbilt-Ingram Cancer Center
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - Harrington Cancer Center
  - Dallas, Texas, Forenede Stater, 75230
    - Medical City Dallas Hospital
  - San Antonio, Texas, Forenede Stater, 78229-3993
    - Methodist Children's Hospital of South Texas
  - San Antonio, Texas, Forenede Stater, 78207
    - University of Texas Health Science Center at San Antonio
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L. Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84157
    - Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center - Provo
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Regional Medical Center - East Campus
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute at University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84103
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists at UCS Cancer Center
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology, Incorporated
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest Virginia Regional Cancer Center at Wellmonth Health
- Washington
  - Bellingham, Washington, Forenede Stater, 98225
    - St. Joseph Cancer Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Olympic Hematology and Oncology
  - Centralia, Washington, Forenede Stater, 98531-9027
    - Providence Centralia Hospital
  - Federal Way, Washington, Forenede Stater, 98003
    - St. Francis Hospital
  - Kennewick, Washington, Forenede Stater, 99336
    - Columbia Basin Hematology
  - Mount Vernon, Washington, Forenede Stater, 98273
    - Skagit Valley Hospital Cancer Care Center
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence St. Peter Hospital Regional Cancer Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison Poulsbo Hematology and Onocology
  - Puyallup, Washington, Forenede Stater, 98372
    - Good Samaritan Cancer Center
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical, PLLC
  - Seattle, Washington, Forenede Stater, 98112
    - Group Health Central Hospital
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Polyclinic First Hill
  - Seattle, Washington, Forenede Stater, 98195
    - University Cancer Center at University of Washington Medical Center
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99218
    - Evergreen Hematology and Oncology, PS
  - Tacoma, Washington, Forenede Stater, 98405-3004
    - Franciscan Cancer Center at St. Joseph Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - CCOP - Northwest
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Regional Cancer Center at Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98499
    - St. Clare Hospital
  - Vancouver, Washington, Forenede Stater, 98668
    - Southwest Washington Medical Center Cancer Center
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Medical Center
  - Wenatchee, Washington, Forenede Stater, 98801-2028
    - Wenatchee Valley Medical Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25302
    - West Virginia University Health Sciences Center - Charleston
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
  - Morgantown, West Virginia, Forenede Stater, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
  - Parkersburg, West Virginia, Forenede Stater, 26102
    - Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Schiffler Cancer Center at Wheeling Hospital
- Wisconsin
  - Appleton, Wisconsin, Forenede Stater, 54911-3496
    - Fox Valley Hematology and Oncology - East Grant Street
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Memorial Hospital of Burlington
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic - Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Center for Cancer Treatment & Prevention at Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Care at Regional Cancer Center
  - Elkhorn, Wisconsin, Forenede Stater, 53121
    - Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Oncology Alliance - Franklin
  - Glendale, Wisconsin, Forenede Stater, 53212-1038
    - Oncology Alliance, SC - Milwaukee - East
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53143
    - Oncology Alliance - Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Center for Cancer and Blood
  - Madison, Wisconsin, Forenede Stater, 53792-6164
    - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
  - Madison, Wisconsin, Forenede Stater, 53717
    - Dean Medical Center - Madison
  - Manitowoc, Wisconsin, Forenede Stater, 54221-1450
    - Holy Family Memorial Medical Center Cancer Care Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic - Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Mequon, Wisconsin, Forenede Stater, 53092
    - Aurora Advanced Healthcare East Mequon Clinic
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Medical Consultants, Limited
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Oncology Alliance, SC - Milwaukee - South
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic - Lakeland Center
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology, Limited - Oconto Falls
  - Racine, Wisconsin, Forenede Stater, 53406-5661
    - Aurora Health Center - Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ministry Medical Group at Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic - Indianhead Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Marshfield Clinic at Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital Cancer Center
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology, Limited - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Aurora Health Center - Waukesha
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic - Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Oncology Alliance, SC - Milwaukee - West
  - Weston, Wisconsin, Forenede Stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital
Sydafrika
- - Pretoria, Sydafrika, 0002
    - Pretoria Academic Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Histologisk bekræftet primært melanom af kutan oprindelse
- Trin II (T3 N0 M0 1,5-4,0 mm Breslow dybde)
  - Klinisk negativ regional lymfeknudepatologisk status ukendt ELLER
  - Histologisk negative regionale lymfeknuder
- Trin III (T4 N0 M0)
  - Større end 4,0 mm Breslow-dybde ELLER
- Trin III (T1-4 N1)
  - En lymfeknude positiv mikroskopisk
Patienter skal opfylde mindst 1 af følgende kriterier:
- T2b N0 - primært melanom 1,01-2,0 mm med ulceration, node negativ
- T3a-b N0 - primært melanom 2,01-4,0 mm med og uden ulceration, node negativ
- T4a-b N0 - primært melanom > 4,0 mm med eller uden ulceration, node negativ
- T1a N1a-2a (mikroskopisk) - primært melanom af enhver tykkelse med mikroskopisk positiv lymfeknude (et hvilket som helst antal)
Patienter med en positiv sentinel node bør gennemgå fuldstændig lymfadenektomi af nodalbassinet før undersøgelse
Skal fuldføre al primær behandling (bred udskæring med eller uden lymfadenektomi) og randomiseres i denne undersøgelse inden for 84 dage efter bred udskæring
Skal have gennemgået en tilstrækkelig bred excision af den primære læsion
Alder 18 og derover (kun for ECOG-patienter skal patienter være >=10 år)
Eastern Cooperative Oncology Group (ECOG) Præstationsstatus på 0-1
Tilstrækkelig hæmatopoietisk, lever- og nyrefunktion baseret på følgende tests:
- Hvide blodlegemer (WBC) er mindst 3.000/mm^3
- Blodpladetal mindst 125.000/mm^3
- Hæmatokrit mindst 30%
- Bilirubin ikke mere end 2 gange øvre normalgrænse (ULN)
- Aspartataminotransferase (AST), lactatdehydrogenase (LDH) og alkalisk fosfatase højst 2 gange ULN
- Hvis laktatdehydrogenase eller alkalisk fosfatase er over normalen, er en kontrastforstærket computertomografi (CT)-scanning eller magnetisk resonansbilleddannelse (MRI) af leveren påkrævet for at dokumentere fraværet af tumor
- Blodurea nitrogen (BUN) ikke større end 33 mg/dL ELLER kreatinin ikke større end 1,8 mg/dL
Ingen andre samtidige eller tidligere maligne sygdomme inden for de seneste 5 år undtagen:
- Kræft in situ
- Lobulært karcinom in situ af brystet
- Carcinom in situ af livmoderhalsen
- Atypisk melanocytisk hyperplasi eller Clark 1 melanom in situ
- Basal eller planocellulær hudkræft
Negativ graviditetstest
Fertile patienter skal bruge effektiv prævention under og i 6 måneder efter undersøgelsen

Ekskluderingskriterier:

Kliniske, radiologiske/laboratoriemæssige eller patologiske beviser for ufuldstændigt resekeret melanom eller enhver fjernmetastatisk sygdom
Klinisk palpabel lymfadenopati
Bevis på organisk hjernesyndrom eller signifikant svækkelse af basal kognitiv funktion eller enhver psykiatrisk lidelse, der ville udelukke undersøgelsesdeltagelse
Andre væsentlige medicinske eller kirurgiske tilstande eller medicin eller behandlingsregimer, der ville forstyrre studiedeltagelsen
Gravid eller ammende
Anden historie med invasivt melanom
Autoimmune lidelser eller tilstande af immunsuppression
Historie om aktiv iskæmisk hjertesygdom
Cerebrovaskulær sygdom
Kongestiv hjertesvigt (New York Heart Association klasse III eller IV hjertesygdom)
Forudgående eller samtidig kemoterapi
Tidligere immunterapi inklusive tumorvacciner, interferon, interleukiner, levamisol eller andre biologiske responsmodifikatorer for melanom
Samtidige systemiske kortikosteroider, herunder orale steroider (dvs. prednison, dexamethason), topiske steroidcremer eller -salver eller enhver steroidholdig inhalator
Forudgående eller samtidig strålebehandling
Anden samtidig immunsuppressiv medicin

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Andet: Observation Patienterne gennemgår observation i 4 uger.	Andet: observation Patienterne gennemgår observation i 4 uger. Andre navne: klinisk observation
Eksperimentel: Interferon Alfa-2b Patienter får højdosis interferon alfa-2b IV over 20 minutter dagligt i 5 på hinanden følgende dage. Behandlingen gentages ugentligt i 4 uger i fravær af uacceptabel toksicitet.	Biologisk: interferon alfa-2b Givet IV Andre navne: Intron-A rekombinant interferon alfa IFN-a 2b NSC # 377523

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års tilbagefaldsfri overlevelsesrate Tidsramme: vurderes hver 3. måned i 2 år, hver 6. måned i 3 år	Tilbagefaldsfri overlevelse (RFS) blev defineret som tid fra randomisering til sygdomstilfald eller død af enhver årsag, alt efter hvad der indtrådte først. Patienter uden sygdomstilbagefald blev censureret på sidste sygdomsvurderingsdato kendt for fri for tilbagefald. Kaplan-Meier-metoden blev brugt til at estimere 5-års RFS-raten hos intention-to-treat (ITT) patienter.	vurderes hver 3. måned i 2 år, hver 6. måned i 3 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års samlet overlevelsesrate Tidsramme: vurderes hver 3. måned i 2 år, hver 6. måned i 3 år	Samlet overlevelse (OS) blev defineret som tiden fra randomisering til død uanset årsag. Patienter, der stadig var i live, blev censureret på den sidste kendte levende dato. Kaplan-Meier-metoden blev brugt til at estimere 5-års OS-raten hos ITT-patienterne.	vurderes hver 3. måned i 2 år, hver 6. måned i 3 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

ECOG-ACRIN Cancer Research Group

Samarbejdspartnere

National Cancer Institute (NCI)

NCIC Clinical Trials Group

Children's Oncology Group

Cancer and Leukemia Group B

SWOG Cancer Research Network

Efterforskere

Studiestol: Lawrence E. Flaherty, MD, Barbara Ann Karmanos Cancer Institute
Studiestol: William E. Carson, MD, Ohio State University Comprehensive Cancer Center
Ledende efterforsker: Alberto S. Pappo, MD, Texas Children's Cancer Center
Studiestol: Sanjiv S. Agarwala, MD, St. Luke's Cancer Network at St. Luke's Hospital
Studiestol: John M. Kirkwood, MD, UPMC Cancer Center at UPMC Presbyterian
Studiestol: Michael Smylie, MD, MB, ChB, Cross Cancer Institute at University of Alberta

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

25. marts 1999

Primær færdiggørelse (Faktiske)

1. januar 2015

Studieafslutning (Anslået)

1. oktober 2025

Datoer for studieregistrering

Først indsendt

1. november 1999

Først indsendt, der opfyldte QC-kriterier

26. januar 2003

Først opslået (Anslået)

27. januar 2003

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

28. juni 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. juni 2023

Sidst verificeret

1. juni 2023

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

E1697 (Anden identifikator: ECOG-ACRIN Cancer Research Group)
U10CA023318 (U.S. NIH-bevilling/kontrakt)
CDR0000066727 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Individuelle deltagerdata kan stilles til rådighed efter anmodning i henhold til ECOG-ACRINs datadelingspolitik

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Melanom (hud)

Alma Lasers

Trukket tilbage

Unipolær mikroplasma radiofrekvensenhed: In vivo histologisk undersøgelse

Skin Resurfacing

Forenede Stater
R2 Dermatology

Afsluttet

Evaluering af et nyt dermalt kryoterapisystem

Skin Lightening

Forenede Stater
Syneron Medical

Afsluttet

Klinisk undersøgelse for at evaluere ydeevnen af fraktioneret radiofrekvens til forbedring af hudtekstur via hudresurfacing og rynkereduktion

Skin Resurfacing | Rynkereduktion

Forenede Stater, Canada
University of Split, School of Medicine

Afsluttet

Effekter af Hypericum Perforatum Oil på at fremme hudgendannelse i forskellige humane hudskademodeller

Skin Recovery i forskellige humane hudskademodeller

Kroatien
National Cancer Institute (NCI)
Exelisis

Afsluttet

Cabozantinib-S-Malate sammenlignet med temozolomid eller dacarbazin til behandling af patienter med metastatisk melanom i øjet, der ikke kan fjernes ved kirurgi

Stage IV Uveal Melanoma AJCC v7 | Tilbagevendende uveal melanom | Stage III Uveal Melanoma AJCC v7 | Stage IIIA Uveal Melanoma AJCC v7 | Stadie IIIB Uveal Melanoma AJCC v7 | Stage IIIC Uveal Melanoma AJCC v7

Forenede Stater, Canada
Centre Hospitalier le Mans

Rekruttering

Øjeblikkelig sutur eller rettet sårheling? Sammenlignende undersøgelse af deres respektive værdier efter en Punch Skin Biopsi (CICAT) (CICAT)

Punch Skin Biopsi

Frankrig
The First Affiliated Hospital of Dalian Medical...

Ukendt

Den nye hudstrækningsanordning til behandling af lemmerspændingssår (SSDRCT)

Sår og skader | Trauma | Brud, åben | Skin Expander

Kina
Integrative Skin Science and Research
Burt's Bees Inc.

Rekruttering

Undersøgelse af Skin Balancing Gel Cream Sikkerhed og Indflydelse af Hud Microbiome på Acne Hud

Acne | Skin Microboime

Forenede Stater
National Cancer Institute (NCI)

Afsluttet

Sargramostim, Vaccineterapi eller Sargramostim og Vaccineterapi til forebyggelse af sygdomstilbagefald hos patienter med melanom, der er blevet fjernet ved kirurgi

Fase IV kutan melanom AJCC v6 og v7 | Tilbagevendende melanom | Fase IIIC kutan melanom AJCC v7 | Slimhinde melanom | Iris melanom | Fase IIIA kutan melanom AJCC v7 | Fase IIIB kutan melanom AJCC v7 | Stage IV Uveal Melanoma AJCC v7 | Medium/Large Size Posterior Uveal Melanom | Tilbagevendende uveal melanom | Stage IIIA Uveal Melanoma AJCC v7 og andre forhold

Forenede Stater
PT. Daewoong Infion
Equilab International

Afsluttet

Effekt- og sikkerhedsevaluering af EASYEF® i akutte sår (split-tykkelse hudtransplantatdonorsted)

Hudtransplantatar | Split-Thickness Skin Graft (STSG)

Indonesien

Kliniske forsøg med observation

Centre Hospitalier Régional d'Orléans

Afsluttet

Undersøgelse af cerebral aktivering under forskellige rehabiliteringsopgaver af underekstremiteter i virtuel spejlterapi hos raske forsøgspersoner (ARTHEMIRS2)

Sund og rask

Frankrig
Universidad Autonoma de Madrid

Ukendt

Effekter af motorisk billedsprog og handlingsobservationstræning på nakkerepositionssans hos patienter med kroniske nakkesmerter

Kronisk smerte

Spanien
University of Bergen
European Society of Intensive Care Medicine

Afsluttet

Den meget gamle intensivpatient: Et multinationalt prospektivt observationsstudie (VIP1)

Kritisk sygdom | Alderdom; Svaghed | Overlevelse

Norge
King's College London

Ikke rekrutterer endnu

CAIR forskningsdatabase (CAIR)

Myokardieinfarkt | Hjertesygdomme | Hjerte-kar-sygdomme | Hjertefejl | Betændelse | Myokarditis | Perikarditis
Iain Bressendorff
Ditte Hansen MD PhD; Casper Rydahl MD; Anders Nordholm MD PhD; Eva Gravesen...

Ikke rekrutterer endnu

Cirkulerende faktorer i nefrotisk syndrom

Nefrotisk syndrom | Minimal Change Disease | Membranøs nefropati | Primær Fokal Segmental Glomerulosklerose
MultiCare Health System Research Institute

Rekruttering

Pædiatrisk Normativ Markørløs Bevægelsesanalyse

Teenager | Pædiatrisk ALT

Forenede Stater
Royal Marsden NHS Foundation Trust

Ikke rekrutterer endnu

PROFILERING AF GENUDSTYR I EN VALIDERINGSKORTE AF LOKALT AVANCEREDE OG TILBAGEVENDENDE/METASTATISKE SPytkirtelkræft (INDAGA-UK)

Spytkirtelkræft
Second Affiliated Hospital, School of Medicine,...
Jinhua People's Hospital; Jinhua Municipal Central Hospital; Yiwu Central... og andre samarbejdspartnere

Rekruttering

Tidlige kropstemperaturmål og sammenhæng med prognose hos patienter med hedeslag

Hedeslag

Kina
Mohamed Elsawy

Rekruttering

Ti års retrospektiv undersøgelse af 4 LOCATOR underkæbeproteser.

Knogleresorption

Egypten
Cairo University

Ikke rekrutterer endnu

Forekomsten af variationer i tilknytning og morfologi af Labial MLF på en prøve af voksen egyptisk befolkning

Labial slips

Højdosis interferon alfa til behandling af patienter med trin II eller trin III melanom

Fase III randomiseret undersøgelse af fire ugers højdosis interferon Alfa-2b i trin T2bN0, T3a-bN0, T4a-bN0 og T1-4, N1a,2a (mikroskopisk) melanom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Kliniske forsøg med Melanom (hud)

Kliniske forsøg med observation

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Congo, DR of

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer