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Sunitinib Malate eller Sorafenib Tosylate til behandling af patienter med nyrekræft, der blev fjernet ved kirurgi (ASSURE)

13. januar 2022 opdateret af: National Cancer Institute (NCI)

FORSIKRE: Adjuvans Sorafenib eller Sunitinib til ugunstigt nyrecarcinom

Dette randomiserede fase III-studie undersøger sunitinibmalat for at se, hvor godt det virker sammenlignet med sorafenibtosylat eller placebo til behandling af patienter med nyrekræft, som er blevet fjernet ved operation. Sunitinibmalat og sorafenibtosylat kan stoppe væksten af tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst, og ved at blokere blodgennemstrømningen til tumoren. Indgivelse af sunitinibmalat eller sorafenibtosylat efter operationen kan dræbe eventuelle tumorceller, der er tilbage efter operationen. Det vides endnu ikke, om sunitinibmalat er mere effektivt end sorafenibtosylat eller placebo til behandling af nyrekræft.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At demonstrere en forbedring af sygdomsfri overlevelse hos lokalt fremskredne nyrecellekarcinompatienter, der tilfældigt tildeles adjuverende sunitinib (sunitinib malat) (arm A) eller sorafenib (sorafenib tosylat) (arm B) versus placebo (arm C) efter radikal eller delvis nefrektomi.

SEKUNDÆRE MÅL:

I. At sammenligne den samlede overlevelse af patienter randomiseret til hver af de to regimer med placebo.

II. For yderligere at definere toksiciteten af langvarig administration af sunitinib eller sorafenib i denne patientpopulation.

III. At prospektivt indsamle tumor- og biologiske prøver for at vurdere deres karakteristika og associationer: nye tilgange til at vurdere angiogenesemarkører i væv, blod og urin som forudsigere for sygdomsfri overlevelse og af terapeutisk fordel.

IV. At prospektivt indsamle tumor- og biologiske prøver for at vurdere deres karakteristika og associationer: hyppigheden af onkogen- og tumorsuppressorgenmutationer som forudsigere for sygdomsfri overlevelse og terapeutisk fordel.

V. Prospektivt at indsamle tumor- og biologiske prøver for at vurdere deres karakteristika og associationer: tumor- og genetiske polymorfismer som prædiktorer for sygdomsfri overlevelse og terapeutisk fordel.

VI. At prospektivt indsamle tumor- og biologiske prøver for at vurdere deres karakteristika og associationer: deoxyribonukleinsyre (DNA) methyleringsprofiler som forudsigere for udfald og af terapeutisk fordel.

VII. At prospektivt indsamle tumor- og biologiske prøver for at vurdere deres karakteristika og associationer: Forholdet mellem polymorfismer i lægemiddelmetaboliserende enzymer med steady state-koncentrationer af sorafenib og sunitinib hos udvalgte patienter.

VIII. At studere effekten af målrettet terapi med vaskulær endotelvækstfaktor (VEGF) på cirkulerende endotelceller og cirkulerende endotelstamceller.

IX. At prospektivt vurdere patientrapporteret træthed for at sammenligne omfanget og forløbet af træthed blandt patienter med nyrecellekarcinom (RCC) randomiseret til adjuverende sunitinib (arm A) eller sorafenib (arm B) med placebo (arm C). (Livskvalitetsmål) X. For at evaluere Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue-Short Form (SF)1, en nyudviklet state-of-the-science PROMIS-måling for træthed og at kalibrere PROMIS Fatigue-SF1 med den etablerede, validerede FACIT- Træthedsskala. (Livskvalitetsmål)

OVERSIGT: Patienterne randomiseres til 1 ud af 3 behandlingsarme.

ARM A: Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienterne sunitinib malat oralt (PO) én gang dagligt (QD) i 4 uger og placebo sorafenib tosylat PO QD eller to gange dagligt (BID) i 6 uger.

ARM B: Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienterne sorafenibtosylat PO QD eller BID i 6 uger og placebo sunitinib malat PO QD i 4 uger efterfulgt.

ARM C: Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienter placebo sorafenib tosylat som i arm A og placebo sunitinib malat som i arm B.

I alle arme gentages behandlingen hver 6. uge i 9 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afslutning af undersøgelsesbehandlingen følges patienterne op hver 3. måned i 2 år, hver 6. måned i 3 år og derefter hver 12. måned i 5 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1943

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Centre
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 3P1
    - Clinical Research Unit at Vancouver Coastal Health Authority
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - QEII Health Sciences Centre/Nova Scotia Health Authority
- Ontario
  - Hamilton, Ontario, Canada, L8V 5C2
    - Juravinski Cancer Centre at Hamilton Health Sciences
  - Kitchener, Ontario, Canada, N2G 1G3
    - Grand River Regional Cancer Centre at Grand River Hospital
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Oshawa, Ontario, Canada, L1G 2B9
    - Lakeridge Health Oshawa
  - Ottawa, Ontario, Canada, K1H 8L6
    - Ottawa Hospital and Cancer Center-General Campus
  - Sault Ste Marie, Ontario, Canada, P6B 0A8
    - Algoma District Cancer Program Sault Area Hospital
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Thunder Bay Regional Health Science Centre
  - Toronto, Ontario, Canada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
- Prince Edward Island
  - Charlottetown, Prince Edward Island, Canada, C1A 8T5
    - PEI Cancer Treatment Centre-Queen Elizabeth Hospital
- Quebec
  - Montreal, Quebec, Canada, H2L 4M1
    - CHUM - Hopital Notre-Dame
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Quebec City, Quebec, Canada, G1R 2J6
    - CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Huntsville, Alabama, Forenede Stater, 35805
    - Clearview Cancer Institute
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Forenede Stater, 36608
    - Providence Hospital
  - Mobile, Alabama, Forenede Stater, 36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Glendale, Arizona, Forenede Stater, 85306
    - Banner Thunderbird Medical Center
  - Phoenix, Arizona, Forenede Stater, 85006
    - Banner-University Medical Center Phoenix
  - Phoenix, Arizona, Forenede Stater, 85006
    - Western Regional CCOP
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72901
    - Sparks Regional Medical Center
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
  - Rogers, Arkansas, Forenede Stater, 72758
    - Highlands Oncology Group-Rogers
- California
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord Campus
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Washington Hospital
  - Fullerton, California, Forenede Stater, 92835
    - Saint Jude Medical Center
  - Glendale, California, Forenede Stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forenede Stater, 94904
    - Marin General Hospital
  - Hayward, California, Forenede Stater, 94545
    - Saint Rose Hospital
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Loma Linda, California, Forenede Stater, 92357
    - Veterans Affairs Loma Linda Healthcare System
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Monterey, California, Forenede Stater, 93940
    - Community Hospital of Monterey Peninsula
  - Mountain View, California, Forenede Stater, 94040
    - El Camino Hospital
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Northridge, California, Forenede Stater, 91325
    - Northridge Hospital Medical Center
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forenede Stater, 94602
    - Highland General Hospital
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, Forenede Stater, 94304
    - VA Palo Alto Health Care System
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants
  - Rancho Mirage, California, Forenede Stater, 92270
    - Eisenhower Medical Center
  - Redding, California, Forenede Stater, 96001
    - Shasta Regional Medical Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Sacramento, California, Forenede Stater, 95819
    - Mercy General Hospital
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Diego, California, Forenede Stater, 92103
    - University of California San Diego
  - San Diego, California, Forenede Stater, 92161
    - Veterans Administration-San Diego Medical Center
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Pablo, California, Forenede Stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Truckee, California, Forenede Stater, 96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Vacaville, California, Forenede Stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - Rocky Mountain Regional VA Medical Center
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80217-3364
    - University of Colorado
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80222
    - Colorado Cancer Research Program NCORP
  - Edwards, Colorado, Forenede Stater, 81632
    - Shaw Cancer Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Glenwood Springs, Colorado, Forenede Stater, 81601
    - Valley View Hospital Cancer Center
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Montrose, Colorado, Forenede Stater, 81401
    - Montrose Memorial Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06606
    - Saint Vincent's Medical Center
  - Danbury, Connecticut, Forenede Stater, 06810
    - Danbury Hospital
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Manchester, Connecticut, Forenede Stater, 06040
    - Manchester Memorial Hospital
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20010
    - MedStar Washington Hospital Center
  - Washington, District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20037
    - George Washington University Medical Center
- Florida
  - Boca Raton, Florida, Forenede Stater, 33486
    - Boca Raton Regional Hospital
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Fort Myers, Florida, Forenede Stater, 33901
    - Lee Memorial Health System
  - Fort Myers, Florida, Forenede Stater, 33901
    - Southwest Florida Regional Medical Center
  - Gainesville, Florida, Forenede Stater, 32610
    - University of Florida Health Science Center - Gainesville
  - Gainesville, Florida, Forenede Stater, 32605
    - Florida Cancer Specialists-Gainesville Cancer Center
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist MD Anderson Cancer Center
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Jupiter, Florida, Forenede Stater, 33458
    - Jupiter Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Leesburg, Florida, Forenede Stater, 34788
    - Cancer Centers of Central Florida PA
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orange Park, Florida, Forenede Stater, 32073
    - 21st Century Oncology-Orange Park
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forenede Stater, 32806
    - UF Cancer Center at Orlando Health
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
  - Sarasota, Florida, Forenede Stater, 34236
    - Florida Cancer Specialists - Sarasota Downtown
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
  - Weston, Florida, Forenede Stater, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Dekalb Medical Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Atlanta VA Medical Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Gwinnett Medical Center
  - Macon, Georgia, Forenede Stater, 31201
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forenede Stater, 30060
    - Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc-POB II
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Oncology Inc-Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Pacific Cancer Institute of Maui
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Pocatello, Idaho, Forenede Stater, 83201
    - Portneuf Medical Center
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Cancer Center
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Health
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forenede Stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital Association
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forenede Stater, 60631
    - Presence Resurrection Medical Center
  - Chicago, Illinois, Forenede Stater, 60612
    - Jesse Brown Veterans Affairs Medical Center
  - Chicago, Illinois, Forenede Stater, 60616
    - Mercy Hospital and Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Heartland Cancer Research NCORP
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - AMITA Health Alexian Brothers Medical Center
  - Elmhurst, Illinois, Forenede Stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Cottage
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Geneva, Illinois, Forenede Stater, 60134
    - LaGrange Oncology Associates
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Illinois CancerCare-Havana
  - Highland Park, Illinois, Forenede Stater, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates Limited
  - Joliet, Illinois, Forenede Stater, 60432
    - Midwest Center for Hematology Oncology
  - Kankakee, Illinois, Forenede Stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Kewanee, Illinois, Forenede Stater, 61443
    - Kewanee Hospital
  - La Grange, Illinois, Forenede Stater, 60525
    - AMITA Health Adventist Medical Center
  - Libertyville, Illinois, Forenede Stater, 60048
    - NorthShore Hematology Oncology-Libertyville
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Spector, David MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Sharis, Christine M MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Stoffel, Thomas J MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
  - Monmouth, Illinois, Forenede Stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forenede Stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Edward Hospital/Cancer Center
  - Naperville, Illinois, Forenede Stater, 60563
    - DuPage Medical Group-Ogden
  - Niles, Illinois, Forenede Stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center Foundation
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Olympia Fields, Illinois, Forenede Stater, 60461
    - Franciscan St. James Health-Olympia Fields Campus
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Pekin Hospital
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forenede Stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forenede Stater, 61104
    - Swedish American Hospital
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie, Illinois, Forenede Stater, 60076
    - Edward H Kaplan MD and Associates
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Winfield, Illinois, Forenede Stater, 60190
    - Northwestern Medicine Central DuPage Hospital
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Goshen, Indiana, Forenede Stater, 46526
    - Goshen Center for Cancer Care
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forenede Stater, 46260
    - Saint Vincent Hospital and Health Care Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Richard L. Roudebush Veterans Affairs Medical Center
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forenede Stater, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Forenede Stater, 47904
    - IU Health Arnett Cancer Care
  - Lafayette, Indiana, Forenede Stater, 47905
    - Horizon Oncology Research LLC
  - Merrillville, Indiana, Forenede Stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC - Ames
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Saint Luke's Hospital
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Heartland Oncology and Hematology LLP
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Cancer Care Institute
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - Saint Luke's Regional Medical Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - MercyOne Waterloo Medical Center
  - Waterloo, Iowa, Forenede Stater, 50701
    - Cedar Valley Medical Specialists
- Kansas
  - Anthony, Kansas, Forenede Stater, 67003
    - Hospital District Sixth of Harper County
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Hutchinson, Kansas, Forenede Stater, 67502
    - Hutchinson Regional Medical Center
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Cancer Center
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forenede Stater, 66210
    - Radiation Oncology Practice Corporation Southwest
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - Shawnee Mission Medical Center-KCCC
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Topeka, Kansas, Forenede Stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Regional Medical Center
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Louisville, Kentucky, Forenede Stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Doctors Carrol, Sheth, Raghavan
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Medical Center
  - Monroe, Louisiana, Forenede Stater, 71202
    - University Health-Conway
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Louisiana State University Health Sciences Center Shreveport
  - Shreveport, Louisiana, Forenede Stater, 71105
    - Highland Clinic
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Portland, Maine, Forenede Stater, 04101
    - Mercy Hospital
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Medical Center- Scarborough Campus
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - Waterville, Maine, Forenede Stater, 04901
    - Maine General Medical Center-Thayer
  - York, Maine, Forenede Stater, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Bethesda, Maryland, Forenede Stater, 20814
    - Suburban Hospital
  - Easton, Maryland, Forenede Stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Easton, Maryland, Forenede Stater, 21601
    - Memorial Hospital at Easton - Shore Regional Cancer Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital of Cecil County
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Salisbury, Maryland, Forenede Stater, 21801
    - Peninsula Regional Medical Center
  - Towson, Maryland, Forenede Stater, 21204
    - UM Saint Joseph Medical Center
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Brighton, Massachusetts, Forenede Stater, 02135
    - Steward Saint Elizabeth's Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Hyannis, Massachusetts, Forenede Stater, 02601
    - Cape Cod Hospital
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Holy Family Hospital
  - Milford, Massachusetts, Forenede Stater, 01757
    - Milford Regional Medical Center
  - Pittsfield, Massachusetts, Forenede Stater, 01201
    - Berkshire Medical Center - Cancer Center
  - Worcester, Massachusetts, Forenede Stater, 01655
    - University of Massachusetts Medical School
  - Worcester, Massachusetts, Forenede Stater, 01605
    - Commonwealth Hematology Oncology PC-Worcester
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital ? Dearborn
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Flint, Michigan, Forenede Stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forenede Stater, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Holland, Michigan, Forenede Stater, 49423
    - Holland Community Hospital
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Muskegon, Michigan, Forenede Stater, 49442
    - Mercy Health Partners-Hackley Campus
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Oncology Care Associates PLLC
  - Southfield, Michigan, Forenede Stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Alexandria, Minnesota, Forenede Stater, 56308
    - Harris, John Gilbert MD (UIA Investigator)
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Brainerd Medical Center Inc
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Etzell, Paul S MD (UIA Investigator)
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Swenson, Wade II, MD (UIA Investigator)
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forenede Stater, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55455
    - University of Minnesota/Masonic Cancer Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - Minneapolis VA Medical Center
  - Montevideo, Minnesota, Forenede Stater, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - Saint Joseph's Hospital - Healtheast
  - Sartell, Minnesota, Forenede Stater, 56377
    - Adult and Pediatric Urology PLLP
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Woodwinds Health Campus
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Southeast Missouri Hospital
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Columbia, Missouri, Forenede Stater, 65201
    - Missouri Cancer Associates
  - Columbia, Missouri, Forenede Stater, 65201
    - Veterans Administration
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forenede Stater, 64114
    - Saint Joseph Health Center
  - Kansas City, Missouri, Forenede Stater, 64114
    - Radiation Oncology Practice Corporation South
  - Kansas City, Missouri, Forenede Stater, 64154
    - Radiation Oncology Practice Corporation - North
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Radiation Oncology Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology Inc
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Saint Louis University Hospital
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - Saint Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Saint Louis-Cape Girardeau CCOP
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Center for Cancer Care and Research
  - Springfield, Missouri, Forenede Stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Billings, Montana, Forenede Stater, 59107
    - Deaconess Medical Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forenede Stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forenede Stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - North Platte, Nebraska, Forenede Stater, 69101
    - Great Plains Health Callahan Cancer Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - Missouri Valley Cancer Consortium
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson-Tahoe Specialty Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Nevada Cancer Research Foundation CCOP
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
- New Hampshire
  - Keene, New Hampshire, Forenede Stater, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Rochester, New Hampshire, Forenede Stater, 03867
    - Frisbie Hospital
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08724
    - Ocean Medical Center
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Medical Center
  - Freehold, New Jersey, Forenede Stater, 07728
    - CentraState Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Livingston, New Jersey, Forenede Stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Montclair, New Jersey, Forenede Stater, 07042
    - Mountainside Hospital
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Pennington, New Jersey, Forenede Stater, 08534
    - Capital Health Medical Center-Hopewell
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Hospital
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Hematology Oncology Associates
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - Christus Saint Vincent Regional Cancer Center
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - Christus Saint Vincent Regional Medical Center
- New York
  - Albany, New York, Forenede Stater, 12208
    - New York Oncology Hematology PC -Albany Medical Center
  - Albany, New York, Forenede Stater, 12206
    - New York Oncology Hematology PC - Albany
  - Amsterdam, New York, Forenede Stater, 12010
    - New York Oncology Hematology PC - Amsterdam
  - Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Bronx, New York, Forenede Stater, 10466
    - Montefiore Medical Center-Wakefield Campus
  - Brooklyn, New York, Forenede Stater, 11203
    - Kings County Hospital
  - Brooklyn, New York, Forenede Stater, 11209
    - Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
  - Brooklyn, New York, Forenede Stater, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Buffalo, New York, Forenede Stater, 14215
    - Veterans Affairs Western New York Health Care System-Buffalo
  - Clifton Park, New York, Forenede Stater, 12065
    - New York Oncology Hematology PC - Clifton Park
  - Cooperstown, New York, Forenede Stater, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Glens Falls, New York, Forenede Stater, 12801
    - Adirondack Cancer Center
  - Hudson, New York, Forenede Stater, 12534
    - New York Oncology Hematology PC-Hudson
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health NCORP
  - Manhasset, New York, Forenede Stater, 11030
    - North Shore University Hospital
  - Middletown, New York, Forenede Stater, 10940
    - Orange Regional Medical Center
  - Mount Kisco, New York, Forenede Stater, 10549
    - Northern Westchester Hospital
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10003
    - Mount Sinai Union Square
  - Nyack, New York, Forenede Stater, 10960
    - Nyack Hospital
  - Plattsburgh, New York, Forenede Stater, 12901
    - Champlain Valley Physicians Hospital Medical Center
  - Rexford, New York, Forenede Stater, 12148
    - New York Oncology Hematology PC - Rexford
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14623
    - Interlakes Foundation Inc-Rochester
  - Staten Island, New York, Forenede Stater, 10305
    - Staten Island University Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Troy, New York, Forenede Stater, 12180
    - New York Oncology Hematology PC - Troy
  - Utica, New York, Forenede Stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospital Inc-Memorial Campus
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Cary, North Carolina, Forenede Stater, 27518
    - Waverly Hematology Oncology
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Gastonia, North Carolina, Forenede Stater, 28054
    - CaroMont Regional Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greenville, North Carolina, Forenede Stater, 27834
    - East Carolina University
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - High Point, North Carolina, Forenede Stater, 27262
    - High Point Regional Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Vidant Oncology-Kinston
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Cancer Center
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27104
    - Southeast Clinical Oncology Research (SCOR) Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Akron City Hospital/Cooper Cancer Center
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Barberton Hospital
  - Beachwood, Ohio, Forenede Stater, 44122
    - Cleveland Clinic Cancer Center Beachwood
  - Bellefontaine, Ohio, Forenede Stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Medical Center
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati/Barrett Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Clyde, Ohio, Forenede Stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forenede Stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45420
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45428
    - Veteran Affairs Medical Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Fremont, Ohio, Forenede Stater, 43420
    - Fremont Memorial Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Maumee, Ohio, Forenede Stater, 43537
    - Saint Luke's Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forenede Stater, 44870
    - Firelands Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forenede Stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forenede Stater, 43606
    - The Toledo Hospital/Toledo Children's Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Saint Anne Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wilmington, Ohio, Forenede Stater, 45177
    - Clinton Memorial Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Xenia, Ohio, Forenede Stater, 45385
    - Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Bend, Oregon, Forenede Stater, 97701
    - Bend Memorial Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Portland, Oregon, Forenede Stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Compass Oncology Rose Quarter
  - Salem, Oregon, Forenede Stater, 97301
    - Salem Hospital
  - The Dalles, Oregon, Forenede Stater, 97058
    - Mid-Columbia Medical Center/Celilo Cancer Center
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - Doylestown Hospital
  - DuBois, Pennsylvania, Forenede Stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Kittanning, Pennsylvania, Forenede Stater, 16201
    - Armstrong Center for Medicine and Health
  - Lancaster, Pennsylvania, Forenede Stater, 17604
    - Lancaster General Hospital
  - Lemoyne, Pennsylvania, Forenede Stater, 17043
    - Central PA Hematology-Medical Oncology Associates PC
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Einstein Medical Center Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Pennsylvania Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Aria Health-Torresdale Campus
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Hospital
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Sellersville, Pennsylvania, Forenede Stater, 18960
    - Grand View Hospital
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Main Line Health NCORP
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Cranston, Rhode Island, Forenede Stater, 02920
    - Hematology and Oncology Associates of Rhode Island Inc
  - Pawtucket, Rhode Island, Forenede Stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forenede Stater, 02906
    - Miriam Hospital
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Hospital
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Easley, South Carolina, Forenede Stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greenwood, South Carolina, Forenede Stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forenede Stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Seneca, South Carolina, Forenede Stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Erlanger Medical Center
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Germantown, Tennessee, Forenede Stater, 38138
    - Jones Clinic
  - Jackson, Tennessee, Forenede Stater, 38301
    - Jackson-Madison County General Hospital
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forenede Stater, 37920
    - University of Tennessee - Knoxville
  - Knoxville, Tennessee, Forenede Stater, 37920
    - East Tennessee Baptist Hospital-Mercy Health Partners
  - Memphis, Tennessee, Forenede Stater, 38163
    - University of Tennessee Health Science Center
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Forenede Stater, 37203
    - Nashville Oncology Associates PC
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Austin, Texas, Forenede Stater, 78705
    - Texas Oncology-Austin Midtown
  - Austin, Texas, Forenede Stater, 78731
    - Texas Oncology - Central Austin Cancer Center
  - Austin, Texas, Forenede Stater, 78745
    - Texas Oncology - South Austin Cancer Center
  - Austin, Texas, Forenede Stater, 78758
    - Texas Oncology-Austin North
  - Austin, Texas, Forenede Stater, 78759
    - Texas Oncology Seton Northwest
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forenede Stater, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - Clements University Hospital
  - Dallas, Texas, Forenede Stater, 75231
    - Texas Health Presbyterian Hospital Dallas
  - Duncanville, Texas, Forenede Stater, 75137
    - Dallas Oncology Consultants PA
  - El Paso, Texas, Forenede Stater, 79902
    - The Center for Integrative Cancer Medicine
  - Fort Sam Houston, Texas, Forenede Stater, 78234
    - Brooke Army Medical Center
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Michael E DeBakey VA Medical Center
  - Houston, Texas, Forenede Stater, 77030
    - The Methodist Hospital System
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Baylor Saint Luke's Medical Center
  - Lackland Air Force Base, Texas, Forenede Stater, 78236
    - Wilford Hall Medical Center
  - Lubbock, Texas, Forenede Stater, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - Round Rock, Texas, Forenede Stater, 78665
    - Texas Oncology-Seton Williamson
  - Round Rock, Texas, Forenede Stater, 78681
    - Texas Oncology - Round Rock Cancer Center
  - San Antonio, Texas, Forenede Stater, 78229
    - University Hospital
  - San Antonio, Texas, Forenede Stater, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forenede Stater, 78229
    - Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
  - San Antonio, Texas, Forenede Stater, 78229
    - Audie L Murphy VA Hospital
  - San Marcos, Texas, Forenede Stater, 78666
    - Texas Oncology- San Marcos
  - Temple, Texas, Forenede Stater, 76508
    - Scott and White Memorial Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Murray, Utah, Forenede Stater, 84107
    - Cottonwood Hospital Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Medical Center Regional Cancer Center
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84103
    - Intermountain Health Care
- Vermont
  - Bennington, Vermont, Forenede Stater, 05201
    - Southwestern Vermont Medical Center
  - Berlin, Vermont, Forenede Stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont and State Agricultural College
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology Inc
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
- Washington
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forenede Stater, 98033
    - EvergreenHealth Medical Center
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Port Angeles, Washington, Forenede Stater, 98362
    - Olympic Medical Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Medical Center-First Hill
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Sacred Heart Medical Center and Children's Hospital
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99220
    - Rockwood Clinic
  - Spokane, Washington, Forenede Stater, 99208
    - Providence Holy Family Hospital
  - Tacoma, Washington, Forenede Stater, 98431
    - Madigan Army Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Compass Oncology Vancouver
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Hospital and Clinics
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yakima, Washington, Forenede Stater, 98902
    - Cancer Institutes of Washington PLLC
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54913
    - Fox Valley Hematology and Oncology SC-Appleton
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Aurora Cancer Care-Franklin
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Glendale, Wisconsin, Forenede Stater, 53212
    - Aurora Cancer Care-Glendale
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Madison, Wisconsin, Forenede Stater, 53717
    - Dean Hematology and Oncology Clinic
  - Madison, Wisconsin, Forenede Stater, 53715
    - UW Health Oncology-One South Park
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Froedtert and the Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus UW Cancer Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier:

Præ-kirurgiske kriterier:
- Patienter skal have primært intakt nyrecellekarcinom, kvalificeret til nefrektomi med helbredende hensigt
- Tumorer >= 4 cm OG/ELLER makroskopiske fuldt resekterbare knuder OG/ELLER kirurgisk resekterbar nyrevenetrombe OG/ELLER kirurgisk resektabel inferior vena caval thrombus ved radiologiske kriterier at være klinisk >= pT1bNany (resektabel) M0 sygdom
- Multifokalt ipsilateralt nyrecellekarcinom er tilladt, forudsat at det er fuldt resektabelt og ikke overskrider inklusionskriterierne
Patienter må ikke have nogen historie med fjernmetastaser
Ingen forudgående anti-cancerbehandling for nyrecellekarcinom er tilladt i hverken adjuverende eller neoadjuverende omgivelser; dette omfatter metatektomi for nyrecellekarcinom eller strålebehandling til nyresengen
Patienter må ikke have andre aktuelle maligniteter, bortset fra basalcellehudkræft, planocellulær hudcancer, in situ livmoderhalskræft, duktalt eller lobulært karcinom in situ i brystet; patienter med andre maligniteter er berettigede, hvis de har været kontinuerligt sygdomsfri i >= 5 år før registreringstidspunktet
Patienter må ikke have nogen alvorlig sammenfaldende sygdom, herunder, men ikke begrænset til, følgende: klinisk signifikant kardiovaskulær sygdom (f. ukontrolleret hypertension, myokardieinfarkt, ustabil angina); New York Heart Association grad II eller større kongestiv hjertesvigt; alvorlig hjertearytmi, der kræver medicin; grad II eller større perifer vaskulær sygdom; eller psykiatrisk sygdom/sociale situationer, der ville begrænse overholdelse af studiekrav
Patienter må ikke have nogen af følgende inden for de 6 måneder før studiets lægemiddeladministration: myokardieinfarkt, svær/ustabil angina, koronar/perifer arterie bypassgraft, symptomatisk kongestiv hjertesvigt, cerebrovaskulær ulykke eller forbigående iskæmisk anfald eller lungeemboli
Patienten må ikke have igangværende ventrikulære hjertedysrytmier af National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.0 grad >= 2; patienter med en anamnese med alvorlig ventrikulær arytmi (ventrikulær takykardi [VT] eller ventrikulær fibrillation [VF] >= 3 slag i træk) er også udelukket; desuden er patienter med igangværende atrieflimren ikke kvalificerede
Patienter skal have korrigeret QT (QTc) interval < 500 msek på baseline elektrokardiogram (EKG)
Patienten må ikke have hypertension, der ikke kan kontrolleres med medicin (>= diastolisk blodtryk 100 mm Hg trods optimal medicinsk behandling)
Patienten må ikke have eksisterende skjoldbruskkirtelabnormitet med thyreoideastimulerende hormon, som ikke kan opretholdes i normalområdet med medicin
Hvis hun er kvinde, må patienten ikke være gravid eller ammende; alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse inden for 2 uger før forhåndsregistrering for at udelukke graviditet; hvis præregistrering sker før operationen, skal blod- eller urinundersøgelsen gentages inden for 2 uger før randomisering for at udelukke graviditet; (bemærk: hvis en kvinde bliver gravid, mens hun deltager i denne undersøgelse, skal hun straks informere sin behandlende læge)
Kvinder i den fødedygtige alder og mænd skal være enige om at bruge en accepteret og effektiv præventionsmetode før studiestart og i hele studiedeltagelsens varighed; hvis en kvinde bliver gravid, mens hun deltager i denne undersøgelse, skal hun straks informere sin behandlende læge; hvis en mand imprægnerer en kvinde, mens han deltager i denne undersøgelse, skal han straks informere sin behandlende læge
Patienter med kendt human immundefektvirus (HIV) er udelukket
BERETNINGSKRITERIER EFTER RADIKAL ELLER DELVIS NEFREKTOMI
Datoen for randomisering skal være mindre end 12 uger efter operationsdatoen; patienter skal være kommet sig over eventuelle operationsrelaterede komplikationer
Inden for 4 uger før randomisering skal patienterne opfylde præoperative berettigelseskrav
Patienter skal have histologisk eller cytologisk bekræftet nyrecellekarcinom. Ved at bruge 2002 (American Joint Committee on Cancer [AJCC] 6. udgave) TNM Staging, skal patienter være en af følgende:
- pT1b G3-4 N0 (eller pNX hvor klinisk N0) M0
- pT2 G (enhver) N0 (eller pNX hvor klinisk N0) M0
- pT3 G (enhver) N0 (eller pNX hvor klinisk N0) M0
- pT4 G (enhver) N0 (eller pNX hvor klinisk N0) M0 eller
- T (enhver) G (en hvilken som helst) N+ (fuldstændig fjernelse) M0
  - Patienter med mikrovaskulær invasion af nyrevenen af enhver grad eller stadie (så længe som M0) er også kvalificerede
  - Patienter skal have gennemgået en fuldstændig kirurgisk resektion (radikal nefrektomi eller partiel nefrektomi) ved enten åben eller laparoskopisk teknik; klinisk evidens for lymfeknudepositivitet kræver fjernelse af alle klinisk positive knuder; kirurger bør udpege omfanget af knudedissektion; alle kirurgiske prøver skal have negative marginer; patienter med positive nyrevenemarginer er berettigede, medmindre der er invasion af renalvenevæggen ved marginen (forudsat at ingen andre marginer er positive)
Patienter må ikke have samlende ductcarcinomer eller medullære carcinomer
Patienter skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0-1
Patienter skal have en absolut baseline venstre ventrikulær ejektionsfraktion (LVEF) på >= 50 % ved multigated acquisition (MUGA) scanning inden for 4 uger før randomisering
Patienter skal have paraffinindlejret tumorprøve til rådighed til central kernegennemgang af tumorhistologi og andre korrelative undersøgelser; tumorprøver vil blive sendt som specificeret
Patienter må ikke have tegn på resterende eller metastatisk nyrecellekræft som dokumenteret på computertomografi (CT) scanninger af brystet, abdomen og bækkenet, alle med oral og intravenøs (IV) kontrast (magnetisk resonansbilleddannelse [MRI] scanninger af abdomen) og bækken med gadolinium og en ikke-kontrast CT af brystet kan erstattes, hvis patienten ikke er i stand til at få foretaget CT-scanninger med intravenøs kontrast); patienter, der ikke er i stand til at tolerere hverken gadolinium eller IV-kontrast, bør ikke deltage i denne undersøgelse (begrænsninger for en patients nyrefunktion bør tages i betragtning ved screening for denne undersøgelse)
Scanninger skal indhentes inden for 4 uger efter randomisering; ændringer på disse scanninger, der menes at være postkirurgiske, skal dokumenteres
Patienter uden rapporterede lymfeknuder i den resekerede kirurgiske prøve og et rapporteret patologisk stadium (postnephrektomi) af pNX SKAL gennemgå en postoperativ kontrastforstærket CT-scanning (eller MR med gadolinium) inden for 4 uger efter randomisering for at dokumentere, at der ikke er nogen tegn på resterende sygdom
Patienter må ikke tage cytokrom P450 enzym-inducerende antiepileptiske lægemidler (phenytoin, carbamazepin eller phenobarbital), perikon, ketoconazol, dexamethason, de rytmiske lægemidler (terfenadin, quinidin, procainamid, sotalaprimid, sotalol, bedolid, flodilbu, beamid), risperidon, rifampin, grapefrugt eller grapefrugtjuice inden for to uger efter randomisering og i løbet af terapien; (medicin er ikke forbudt, medmindre det er nævnt ovenfor); topiske og inhalerede steroider er tilladt
Patienter må ikke modtage andre forsøgsmidler mod kræft i undersøgelsesperioden
Patienter må ikke have en alvorlig sammenfaldende sygdom, herunder igangværende eller aktiv infektion, der kræver forældrenes antibiotika
Absolut granulocyttal (AGC) >= 1.500/mm^3
Blodpladetal >= 100.000/mm^3
Serumkreatinin =< 2,0 x øvre grænse for normal (ULN) eller beregnet kreatininclearance (CrCl) >= 30 ml/min (ingen af stofferne udskilles af nyrerne)
Total bilirubin =< 1,5 x øvre normalgrænse (ULN)
Serum glutaminsyre oxaloeddikesyre transaminase (SGOT) og serum glutamat pyruvat transaminase (SGPT) =< 2,5 x ULN
Patienter skal kunne sluge piller

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Dobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm A (sunitinib malat, placebo) Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienterne sunitinib malat PO QD i 4 uger og placebo sorafenib tosylat PO QD eller BID i 6 uger.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Andet: Placebo Givet PO Andre navne: placebo terapi PLCB falsk terapi Medicin: Sunitinib Malate Givet PO Andre navne: Sutent SU011248 SU11248 sunitinib
Eksperimentel: Arm B (sorafenibtosylat, placebo) Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienterne sorafenibtosylat PO QD eller BID i 6 uger og placebo sunitinib malat PO QD i 4 uger efterfulgt.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Andet: Placebo Givet PO Andre navne: placebo terapi PLCB falsk terapi Medicin: Sorafenib tosylat Givet PO Andre navne: BAY 54-9085 Nexavar BAY 43-9006 Tosylate sorafenib
Placebo komparator: Arm C (placebo) Begyndende 4-12 uger efter radikal eller partiel nefrektomi får patienter placebo sorafenib tosylat som i arm A og placebo sunitinib malat som i arm B.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Andet: Placebo Givet PO Andre navne: placebo terapi PLCB falsk terapi

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Sygdomsfri overlevelse (DFS) Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart	Sygdomsfri overlevelse (DFS) er defineret som tid fra randomisering til recidiv, udvikling af anden primær cancer (undtagen lokaliseret bryst- eller prostatacancer eller non-melanom hudkræft) eller død af enhver årsag. Patienter, der var i live uden recidiv eller kvalificerende anden primær cancer, blev censureret på datoen for sidste sygdomsevaluering.	Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års samlet overlevelsesrate Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart	Samlet overlevelse er defineret som tiden fra randomisering til død uanset årsag. Patienter uden dødsdato blev censureret på datoen for sidste kontakt. Kaplan-Meier-metoden blev brugt til at estimere 5-års overlevelsesrate.	Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart
Andel af patienter med hjertehændelser Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart	Hjertehændelse er defineret som venstre ventrikulær ejektionsfraktion (LVEF) under den institutionelle nedre normalgrænse, hvor faldet var >15 % absolutte procentpoint fra baseline inden for 6 måneder.	Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart
5-års sygdomsfri overlevelse (DFS) rate blandt patienter med klarcellet histologi Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart	Sygdomsfri overlevelse (DFS) er defineret som tid fra randomisering til recidiv, udvikling af anden primær cancer (undtagen lokaliseret bryst- eller prostatacancer eller non-melanom hudkræft) eller død af enhver årsag. Patienter, der var i live uden recidiv eller kvalificerende anden primær cancer, blev censureret på datoen for sidste sygdomsevaluering. 5-års DFS-rate er andelen af patienter, der er i live og sygdomsfri efter 5 år baseret på Kaplan-Meier-estimatet.	Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart

Andre resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Sammenhængen mellem angiogenesemarkører og sygdomsfri overlevelse Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Sammenhængen mellem sygdomsfri overlevelse og hyppigheden af onkogen såvel som tumorundertrykkende genmutationer Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Sammenhængen mellem tumor og genetiske polymorfismer og sygdomsfri overlevelse Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Forbindelsen mellem deoxyribonukleinsyre (DNA) methyleringsprofiler og sygdomsfri overlevelse Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Forholdet mellem polymorfier i lægemiddelmetaboliserende enzymer med steady state-koncentrationer af sorafenib og sunitinib hos udvalgte patienter Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Effekten af vaskulær endotelvækstfaktor (VEGF) målrettet terapi på cirkulerende endotelceller og cirkulerende endotelprogenitorer Tidsramme: Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart		Vurderes hver 3. måned, hvis patienten er < 2 år fra studiestart; hver 6. måned, hvis patienten er 2 - 5 år fra studiestart; derefter årligt, hvis patienten er 5 - 10 år fra studiestart
Patientrapporteret træthed ved hjælp af funktionel vurdering af kronisk sygdomsterapi (FACIT) - træthedsskala Tidsramme: Vurderet ved baseline, 10 uger og 22 uger		Vurderet ved baseline, 10 uger og 22 uger
Patientrapporteret træthed ved hjælp af patientrapporteret udfaldsmålingsinformationssystem (PROMIS) Træthedskortform Tidsramme: Vurderet ved baseline, 10 uger og 22 uger	PROMIS Fatigue short form er et nyudviklet state-of-the-videnskab PROMIS-mål for træthed	Vurderet ved baseline, 10 uger og 22 uger
Sammenhængen mellem scanningsfrekvens og udvikling af kongestiv hjertesvigt Tidsramme: Vurderet til 3, 6 og 12 måneder		Vurderet til 3, 6 og 12 måneder
Hyppighed af klinisk signifikant kongestiv hjertesvigt (CHF) grad 3 eller højere ved brug af de fælles terminologikriterier for bivirkninger Version 4.0 Tidsramme: Vurderet hver 6. uge under behandling og i 30 dage efter endt behandling		Vurderet hver 6. uge under behandling og i 30 dage efter endt behandling

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Samarbejdspartnere

NCIC Clinical Trials Group

Southwest Oncology Group

Cancer and Leukemia Group B

Efterforskere

Ledende efterforsker: Naomi S Balzer-Haas, ECOG-ACRIN Cancer Research Group

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

24. april 2006

Primær færdiggørelse (Faktiske)

27. august 2015

Studieafslutning (Faktiske)

1. september 2021

Datoer for studieregistrering

Først indsendt

16. maj 2006

Først indsendt, der opfyldte QC-kriterier

16. maj 2006

Først opslået (Skøn)

17. maj 2006

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

8. februar 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. januar 2022

Sidst verificeret

1. januar 2022

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NCI-2009-00534 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180820 (U.S. NIH-bevilling/kontrakt)
U10CA021115 (U.S. NIH-bevilling/kontrakt)
CAN-NCIC-E2805
SWOG-E2805
ECOG-E2805
CDR0000478976
CALGB-E2805
E2805 (Anden identifikator: CTEP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Klarcellet nyrecellekarcinom

Universitaire Ziekenhuizen KU Leuven

Aktiv, ikke rekrutterende

Helkropsdiffusionsvægtet magnetisk resonansbilleddannelse til iscenesættelse og behandlingsforudsigelse af lymfom

Lymfom | Hodgkin lymfom | Non-Hodgkin lymfom (follikulært, diffust B-cel lymfom, PTLD og Mantle Cel lymfom)

Belgien
University of Bologna
Novartis

Ukendt

Undersøgelse af STI571 i behandling af patienter med idiopatisk hypereosinofil syndrom (HES) og eosinofile leukæmier

Myeloproliferative lidelser | Hypereosinofilt syndrom | Kronisk eosinofil leukæmi (CEL)

Italien
AHS Cancer Control Alberta
Cross Cancer Institute

Afsluttet

Fase II-forsøg med konsoliderende thoraxstrålebehandling for småcellet lungekræft i omfattende stadier

Omfattende Stage Small Cel Lung Cancer

Canada
Association Pour La Recherche des Thérapeutiques...

Afsluttet

Et BIOmarkør-drevet forsøg med Nivolumab og Ipilimumab eller VEGFR tKi i naiv metastatisk nyrekræft (BIONIKK)

Clear Cell Metastatic Renal Cell Carcinoma

Frankrig
Regeneron Pharmaceuticals

Ledig

Medfølende brug af Ubamatamab

Epiteloid sarkom | Renal Medullary Carcinoma (RMC)
Sunnybrook Health Sciences Centre
Pfizer

Afsluttet

Stereotaktisk strålebehandling for metastatisk nyrekræft, der behandles med Sunitinib

Clear Cell Metastatic Renal Cell Carcinoma

Canada
Mayo Clinic

Rekruttering

Terapeutisk plasmaudveksling med enfortumab Vedotin og pembrolizumab til behandling af kræft i blæren (RECIPE-B1)

Metastatisk blæreurothelial karcinom | Metastatisk nyrebækken og Ureter Urothelial Carcinoma | Stadie IV blærekræft AJCC v7 | Refraktær blære Urothelial Carcinom | Ildfast renal bækken og uroter urotelkarcinom | Trin IV Renal bækken og ureter kræft AJCC V7

Forenede Stater
Kelly Fitzgerald, MD
Exelixis

Ikke rekrutterer endnu

Zanzalintinib til metastatisk klar celle nyrecellekarcinom med knoglemetastaser (ZAMBONI)

Klarcellet nyrecellekarcinom | Metastatisk nyrecellekarcinom | Metastatisk kræft | Clear Cell Renal Cancer | Klarcellet nyrekarcinom | Metastaser til knogler | Klarcellet nyrecellekarcinom Metastatisk | Clear Cell Renal Cell Cancer (ccRCC) | Knoglemetastaser af en ondartet tumor | Knogler, metastatisk kræft

Forenede Stater
Children's Oncology Group
National Cancer Institute (NCI)

Afsluttet

Kombination af kemoterapi, strålebehandling og/eller kirurgi til behandling af patienter med højrisiko nyretumorer

Klarcellet nyrecellekarcinom | Stadie III nyrecellekræft | Stadie IV nyrecellekræft | Clear Cell Sarkom af Nyren | Papillært nyrecellekarcinom | Rhabdoid tumor i nyren | Stadie I nyrecellekræft | Barndoms nyrecellekarcinom | Stadie II nyrecellekræft | Stadie I Renal Wilms Tumor | Stadie II Renal Wilms Tumor | Stadie... og andre forhold

Forenede Stater, Canada, Australien, New Zealand, Puerto Rico
Telix International Pty Ltd
Grand Pharmaceutical (China) Co., Ltd.

Afsluttet

Evaluering af 89Zr-TLX250 PET/CT hos kinesiske patienter med ubestemte nyremasser eller mistanke om tilbagevendende renal clear cell carcinom (ZIRDOSE-CP)

Klarcellet nyrecellekarcinom | Tilbagevendende nyrecellekræft | Mistænkt tilbagevendende renal clear cell carcinom

Kina

Kliniske forsøg med Laboratoriebiomarkøranalyse

Centre Médico-Chirurgical de Réadaptation des Massues...

Rekruttering

Karakterisering af synsopfattelsesforstyrrelser hos patienter med idiopatisk skoliose (EYAIS)

Idiopatisk skoliose

Frankrig
Liao Jian An

Rekruttering

Meridianenergiændringer hos patienter med hoved- og nakkekræft efter kemoterapi eller strålebehandling

Hoved- og halskræft

Taiwan
Progenity, Inc.

Afsluttet

Udvidet ikke-invasiv genomisk medicinsk vurdering: Enigma-undersøgelsen

Downs syndrom | Aneuploidi | DiGeorges syndrom | Turners syndrom | Klinefelters syndrom | Kromosom sletning | Edwards syndrom | Patau syndrom

Forenede Stater
Nantes University Hospital

Ikke rekrutterer endnu

Reproducerbarhed af dental bidmærkeoverlayanalyse ved hjælp af digitale 3D-modeller hos voksne deltagere (OVERLAY-REPRO)

Rettsmedicinsk Tandlægevidenskab | Bidanalyse
Fondation Lenval

Trukket tilbage

Indflydelse af træthed på gangmønsteret hos patienter med cerebral parese.

Cerebral Parese

Frankrig
IRCCS Eugenio Medea

Afsluttet

Biomarkørers baner for tidlig intervention hos søskende til børn med autismespektrumforstyrrelse

Autismespektrumforstyrrelse | Tidlig indsats

Italien
Oregon Health and Science University
4DMedical

Tilmelding efter invitation

Ventilationsubalancer ved let til moderat kronisk obstruktiv lungesygdom (VAPOR)

Lungesygdomme | KOL | Luftvejssygdom | Dyspnø

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Bekræft præstationen i klinisk praksis af den fordybende Virtual Reality Platform GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral Parese | Erhvervet hjerneskade

Italien
Modarres Hospital

Afsluttet

Renal parenkymal kernenålbiopsi

Komplikationer | Billedstyret biopsi | Nyre Glomerulus

Iran, Islamisk Republik
Healthy.io Ltd.

Afsluttet

[Prøvning af enhed, der ikke er godkendt eller godkendt af U.S. FDA]

Albuminuri

Forenede Stater

Sunitinib Malate eller Sorafenib Tosylate til behandling af patienter med nyrekræft, der blev fjernet ved kirurgi (ASSURE)

FORSIKRE: Adjuvans Sorafenib eller Sunitinib til ugunstigt nyrecarcinom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Klarcellet nyrecellekarcinom

Kliniske forsøg med Laboratoriebiomarkøranalyse

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Saudi Arabia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer