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Paclitaxel, Nab-paclitaxel eller Ixabepilone med eller uden Bevacizumab til behandling af patienter med stadium IIIC eller stadium IV brystkræft

6. oktober 2022 opdateret af: National Cancer Institute (NCI)

Et randomiseret fase III-forsøg med ugentlig paclitaxel sammenlignet med ugentlig nanopartikelalbumin bundet Nab-paclitaxel eller Ixabepilon med eller uden bevacizumab som førstelinjebehandling for lokalt tilbagevendende eller metastatisk brystkræft

Dette randomiserede fase III-studie studerer bivirkningerne og hvor godt forskellige kemoterapiregimer med eller uden bevacizumab virker ved behandling af patienter med stadium IIIC eller stadium IV brystkræft. Lægemidler brugt i kemoterapi, såsom paclitaxel, paclitaxel albumin-stabiliseret nanopartikelformulering (nab-paclitaxel) og ixabepilone, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig, eller ved at forhindre dem i at sprede sig. Bevacizumab kan blokere tumorvækst ved at målrette mod visse celler og bremse væksten af blodkar til tumoren. Det vides endnu ikke, hvilket behandlingsregime der er mere effektivt til behandling af patienter med brystkræft.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At sammenligne den progressionsfrie overlevelse (PFS) hos patienter med metastatisk brystkræft, der får nab-paclitaxel versus paclitaxel (kontrolarm).

II. At sammenligne PFS hos patienter, der får ixabepilon, versus paclitaxel.

SEKUNDÆRE MÅL:

I. At sammenligne den objektive responsrate, varigheden af respons og tid til behandlingssvigt hos patienter, der får nab-paclitaxel versus paclitaxel, og separat sammenligne disse endepunkter hos patienter, der får ixabepilone versus paclitaxel.

II. At sammenligne 12-måneders progressionshastigheden hos patienter, der får nab-paclitaxel versus paclitaxel, og separat sammenligne dette endepunkt hos patienter, der får ixabepilone versus paclitaxel.

III. For at bestemme toksicitet hos patienter, der får nab-paclitaxel sammenlignet med paclitaxel, og hos patienter, der får ixabepilon sammenlignet med paclitaxel.

IV. At sammenligne den samlede overlevelse hos patienter, der får nab-paclitaxel versus paclitaxel, og at sammenligne den samlede overlevelse hos patienter, der får ixabepilone, i forhold til paclitaxel separat.

V. At evaluere sammenhængen mellem udskilt protein, sur, cysteinrig (SPARC) overekspression og ændringer i blodniveauer af caveolin-1 (Cav-1) til PFS og sekundære endepunkter for respons under behandling med nab-paclitaxel sammenlignet med paclitaxel , og med ixabepilon sammenlignet med paclitaxel.

VI. At evaluere sammenhængen mellem ændringer i blodniveauer af cirkulerende tumorceller (CTC'er) og cirkulerende endotelceller (CEC'er) til PFS og sekundære endepunkter for respons under behandling med nab-paclitaxel sammenlignet med paclitaxel og med ixabepilone sammenlignet med paclitaxel.

VII. At evaluere sammenhængen mellem ekspressionsniveauer af de mikrotubulusassocierede proteiner tau og beta-tubulin isotypesammensætning med PFS og sekundære endepunkter for respons under behandling med nab-paclitaxel sammenlignet med paclitaxel og med ixabepilone sammenlignet med paclitaxel.

VIII. At undersøge et potentielt cytokrom P450, familie 2, underfamilie C polypeptid 8, 2, 3 (CYP2C8*2/*3) ved paclitaxel-interaktion med hensyn til progressionsfri overlevelse (PFS).

IX. For at bestemme om CYP2C8*2 og CPY2C8*3 er forbundet med paclitaxel-induceret perifer neuropati.

X. At udføre eksplorativ analyse af cytokrom P450, familie 3, underfamilie A, polypeptid 4 (CYP3A4), cytokrom P450, familie 3, underfamilie A, polypeptid 5 (CYP3A5), ATP-bindende kassette, underfamilie B (MDR/TAP ), medlem 1 (ABCB1) og ATP-bindende kassette, underfamilie C (CFTR/MRP), medlem 2 (ABCC2) polymorfismer med respons- og toksicitetsprofiler.

XI. At prospektivt indsamle data om sociodemografi, ikke-kræftsygdomme og modtagelse af post-forsøgsterapi for at evaluere rollen af potentielle forskelle på overlevelse fra kræft.

XII. At evaluere forholdet mellem fysisk aktivitetsadfærd på tidspunktet for tilmelding til protokollen og progressionsfri og samlet overlevelse.

XIII. At identificere baseline faktorer, der forudsiger risikoen for grad 3, 4 eller 5 toksicitet hos patienter, der modtager behandling med ugentlig paclitaxel, nab-paclitaxel eller ixabepilon kombineret med eller uden bevacizumab.

XIV. At udføre en eksplorativ analyse af, om andre faktorer inkluderet i patientvurderinger (enten individuelt eller i kombination) forudsiger risikoen for grad 3, 4 eller 5 toksicitet hos patienter, der får paclitaxel, nab-paclitaxel eller ixabepilon kombineret med eller uden bevacizumab, med et specifikt fokus på forholdet mellem allerede eksisterende hypertension eller neuropati.

XV. At sammenligne associeringer af baseline-faktorer med grad 3, 4 eller 5 toksicitet hos patienter, der får paclitaxel, nab-paclitaxel eller ixabepilon kombineret med eller uden bevacizumab.

XVI. At undersøge, om longitudinelle ændringer i faktorer er i forbindelse med forekomsten af grad 3, 4 eller 5 toksiciteter hos patienter med ugentlig paclitaxel, nab-paclitaxel eller ixabepilon kombineret med eller uden bevacizumab.

XVII. At udforske sammenhængen mellem grad 2-4 neuropati og longitudinelle ændringer i følgende funktionelle statusmål: a) Ældre amerikanere ressourcer og tjenester (OARS) Multidimensional Functional Assessment Questionnaire (MFAQ) (Instrumental Activities of Daily Living [IADL]); b) Medical Outcomes Study (MOS) Fysisk funktionsevne; c) Karnofsky præstationsstatus vurderet sundhedsprofessionel; d) Timed "Op og gå"; e) OARS Fysisk Sundhedsafdeling.

OVERSIGT: Patienterne randomiseres til 1 ud af 3 behandlingsarme.

ARM A (UGENTLIG PACLITAXEL): Patienter får paclitaxel intravenøst (IV) over 1 time på dag 1, 8 og 15. Patienter kan også modtage bevacizumab IV over 30-90 minutter på dag 1 og 15.

ARM B (UGENTLIG NAB-PACLITAXEL): Patienter modtager paclitaxel albumin-stabiliseret nanopartikelformulering IV over 30 minutter på dag 1, 8 og 15. Patienter kan også modtage bevacizumab som i arm A.

ARM C (UGENTLIG IXABEPILONE): Patienter får ixabepilone IV over 60 minutter på dag 1, 8 og 15. Patienter kan også modtage bevacizumab som i arm A. (lukket for optjening pr. 18/7/11)

I alle arme gentages behandlingen hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afslutning af studieterapien følges patienterne hver 6. måned i 2 år og derefter årligt i op til 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

799

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Arizona
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Fort Smith, Arkansas, Forenede Stater, 72901
    - Sparks Regional Medical Center
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital
- California
  - Anaheim, California, Forenede Stater, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente-Fresno
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forenede Stater, 94904
    - Marin General Hospital
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente West Los Angeles
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Mountain View, California, Forenede Stater, 94040
    - El Camino Hospital
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forenede Stater, 94602
    - Highland General Hospital
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Tumor Institute
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center -San Diego
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Diego, California, Forenede Stater, 92103
    - UC San Diego Medical Center - Hillcrest
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Francisco, California, Forenede Stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92078
    - Kaiser Permanente-San Marcos
  - San Pablo, California, Forenede Stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80222
    - Western States Cancer Research NCORP
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20010
    - MedStar Washington Hospital Center
  - Washington, District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Boca Raton, Florida, Forenede Stater, 33428
    - Lynn Regional Cancer Center - West
  - Boca Raton, Florida, Forenede Stater, 33486
    - Boca Raton Comprehensive Cancer Center
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Halifax Health Medical Center-Centers for Oncology
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forenede Stater, 32605
    - Florida Cancer Specialists-Gainesville Cancer Center
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist MD Anderson Cancer Center
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Jupiter, Florida, Forenede Stater, 33458
    - Jupiter Medical Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
- Georgia
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Dekalb Medical Center
  - Dublin, Georgia, Forenede Stater, 31021
    - Dublin Hematology Oncology Care PC
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Northside Hospital - Gwinnett
  - Marietta, Georgia, Forenede Stater, 30060
    - WellStar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Kailua, Hawaii, Forenede Stater, 96734
    - Castle Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Pacific Cancer Institute of Maui
- Idaho
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forenede Stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital Association
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Heartland Cancer Research NCORP
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - AMITA Health Alexian Brothers Medical Center
  - Elmhurst, Illinois, Forenede Stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Cottage
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Illinois CancerCare-Havana
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Forenede Stater, 60435
    - Duly Health and Care Joliet
  - Kankakee, Illinois, Forenede Stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - La Grange, Illinois, Forenede Stater, 60525
    - AMITA Health Adventist Medical Center
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Monmouth, Illinois, Forenede Stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forenede Stater, 61462
    - Holy Family Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Pekin Hospital
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forenede Stater, 61104
    - Swedish American Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Goshen, Indiana, Forenede Stater, 46526
    - Goshen Center For Cancer Care
  - Indianapolis, Indiana, Forenede Stater, 46260
    - Saint Vincent Hospital and Health Care Center
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forenede Stater, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Forenede Stater, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC - Ames
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Cancer Care Institute
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - Saint Luke's Regional Medical Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - MercyOne Waterloo Medical Center
  - Waterloo, Iowa, Forenede Stater, 50701
    - Cedar Valley Medical Specialists
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Ascension Via Christi - Pittsburg
  - Prairie Village, Kansas, Forenede Stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - Advent Health - Shawnee Mission Medical Center
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Louisville, Kentucky, Forenede Stater, 40215
    - Doctors Carrol, Sheth, Raghavan
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic PLLC
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Health Center-Covington
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Ochsner Baptist Medical Center
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - Waterville, Maine, Forenede Stater, 04901
    - Maine General Medical Center-Thayer
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Easton, Maryland, Forenede Stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton, Maryland, Forenede Stater, 21921
    - Christiana Care - Union Hospital
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Silver Spring, Maryland, Forenede Stater, 20910
    - Holy Cross Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Danvers, Massachusetts, Forenede Stater, 01923
    - Mass General/North Shore Cancer Center
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Holy Family Hospital
  - Newton, Massachusetts, Forenede Stater, 02462
    - Newton-Wellesley Hospital
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital - Dearborn
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Flint, Michigan, Forenede Stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Midland, Michigan, Forenede Stater, 48670
    - MyMichigan Medical Center Midland
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Hospital Niles
  - Petoskey, Michigan, Forenede Stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Etzell, Paul S MD (UIA Investigator)
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Swenson, Wade II, MD (UIA Investigator)
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forenede Stater, 55355
    - Meeker County Memorial Hospital
  - Mankato, Minnesota, Forenede Stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Southwest Campus
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Centers
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forenede Stater, 64114
    - Saint Joseph Health Center
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology Inc
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63104
    - SSM Health Saint Louis University Hospital
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Center for Cancer Care and Research
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Comprehensive Cancer Care PC
  - Springfield, Missouri, Forenede Stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forenede Stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forenede Stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - Missouri Valley Cancer Consortium
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Nevada Cancer Research Foundation NCORP
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Exeter Hospital
  - Keene, New Hampshire, Forenede Stater, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Laconia, New Hampshire, Forenede Stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Londonderry, New Hampshire, Forenede Stater, 03053
    - The Dana-Farber Cancer Institute at Londonderry
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Pomona, New Jersey, Forenede Stater, 08240
    - AtlantiCare Regional Medical Center -Main Campus
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Sparta, New Jersey, Forenede Stater, 07871
    - Sparta Cancer Treatment Center
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
- New York
  - Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Brooklyn, New York, Forenede Stater, 11235
    - Coney Island Hospital
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Glens Falls, New York, Forenede Stater, 12801
    - Adirondack Cancer Center
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health NCORP
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forenede Stater, 11030
    - North Shore University Hospital
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - Staten Island, New York, Forenede Stater, 10305
    - Staten Island University Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Utica, New York, Forenede Stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospital
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Fayetteville, North Carolina, Forenede Stater, 28304
    - Cape Fear Valley Health System
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Henderson, North Carolina, Forenede Stater, 27536
    - Maria Parham Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Vidant Oncology-Kinston
  - Lumberton, North Carolina, Forenede Stater, 28358
    - Southeastern Regional Medical Center
  - Oxford, North Carolina, Forenede Stater, 27565
    - Granville Medical Center
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Duke Raleigh Hospital
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Rex Cancer Center
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Rocky Mount, North Carolina, Forenede Stater, 27804
    - Nash General Hospital
  - Roxboro, North Carolina, Forenede Stater, 27573
    - Person Memorial Hospital
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Wilmington, North Carolina, Forenede Stater, 28401
    - New Hanover Regional Medical Center/Zimmer Cancer Center
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forenede Stater, 27104
    - Southeast Clinical Oncology Research Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Health System - Barberton Campus
  - Bellefontaine, Ohio, Forenede Stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Canton, Ohio, Forenede Stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Clyde, Ohio, Forenede Stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forenede Stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Maumee, Ohio, Forenede Stater, 43537
    - Saint Luke's Hospital
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forenede Stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forenede Stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wilmington, Ohio, Forenede Stater, 45177
    - Clinton Memorial Hospital
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forenede Stater, 45385
    - Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Norman, Oklahoma, Forenede Stater, 73071
    - Cancer Care Associates-Norman
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Physicians of Oklahoma-Lakeside
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
- Oregon
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Grants Pass, Oregon, Forenede Stater, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Medford, Oregon, Forenede Stater, 97504
    - Asante Health System
  - Medford, Oregon, Forenede Stater, 97504
    - Providence Medford Medical Center
  - Medford, Oregon, Forenede Stater, 97504
    - Rogue Valley Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Portland, Oregon, Forenede Stater, 97216
    - Adventist Medical Center
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - Butler Memorial Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - Doylestown Hospital
  - DuBois, Pennsylvania, Forenede Stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Einstein Medical Center Philadelphia
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Hospital
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forenede Stater, 19390
    - Jennersville Regional Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Main Line Health NCORP
- Rhode Island
  - Pawtucket, Rhode Island, Forenede Stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Hospital
  - Beaufort, South Carolina, Forenede Stater, 29902
    - Beaufort Memorial Hospital
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greenwood, South Carolina, Forenede Stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Myrtle Beach, South Carolina, Forenede Stater, 29572
    - Coastal Cancer Center-Myrtle Beach
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - West Columbia, South Carolina, Forenede Stater, 29169
    - Lexington Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5045
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forenede Stater, 37920
    - University of Tennessee - Knoxville
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Forenede Stater, 37203
    - Nashville Oncology Associates PC
- Texas
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
- Vermont
  - Berlin, Vermont, Forenede Stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont and State Agricultural College
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Charlottesville, Virginia, Forenede Stater, 22901
    - Sentara Martha Jefferson Hospital
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Fairfax, Virginia, Forenede Stater, 22031
    - Inova Schar Cancer Institute
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology Inc
  - Fredericksburg, Virginia, Forenede Stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Martinsville, Virginia, Forenede Stater, 24115
    - Sovah Health Martinsville
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
- Washington
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Sacred Heart Medical Center and Children's Hospital
  - Spokane, Washington, Forenede Stater, 99208
    - Providence Holy Family Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
- West Virginia
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
  - Princeton, West Virginia, Forenede Stater, 24740
    - Princeton Community Hospital
- Wisconsin
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Aurora Cancer Care-Franklin
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Glendale, Wisconsin, Forenede Stater, 53212
    - Aurora Cancer Care-Glendale
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forenede Stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, Forenede Stater, 53717
    - Dean Hematology and Oncology Clinic
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier:

Histologisk bekræftelse af invasiv brystkræft
Stadie IV sygdom eller stadium IIIC sygdom (ved brug af American Joint Committee on Cancer [AJCC] kriterier, 6. udgave) er ikke modtagelig for lokal terapi
Patienter har muligvis ikke en "aktuelt aktiv" anden malignitet ud over ikke-melanom hudcancer; patienter anses ikke for at have en "aktuelt aktiv" malignitet, hvis de har afsluttet behandlingen og af deres læge anses for at have mindre end 30 % risiko for tilbagefald
Patienter med human epidermal vækstfaktor receptor 2 (HER2) negativ sygdom er kvalificerede; patienter med HER2+ sygdom er kvalificerede, forudsat at de tidligere har modtaget trastuzumab eller lapatinib; dokumentation for progression af HER2-styret behandling er ikke påkrævet; Her2/neu-status skal være kendt på tidspunktet for protokolregistrering
Østrogenreceptor (ER) og progesteronreceptor (PgR) status skal være kendt på registreringstidspunktet; ER og/eller PgR >= 1% celler vil blive betragtet som positive
Tidligere behandling kan omfatte adjuverende eller neoadjuverende taxan, dog skal intervallet mellem afslutning af adjuverende eller neoadjuverende terapi og tilbagefald af sygdommen være >= 12 måneder
Ingen forudgående kemoterapi for metastatisk brystkræft
Et hvilket som helst antal tidligere hormonbehandlinger er tilladt; den sidste dosis skal have været indgivet mindst 7 dage før påbegyndelse af protokolbehandling
Forudgående strålebehandling skal være afsluttet mindst 2 uger før studiestart
Behandling med bisfosfonater er tilladt og anbefales i henhold til American Society of Clinical Oncology (ASCO) retningslinjer
Forudgående trastuzumab eller lapatinib påkrævet til patienter med HER2-overudtrykkende tumorer
Forudgående behandling med bevacizumab er tilladt
Patienter må ikke have haft et større kirurgisk indgreb, åben biopsi eller væsentlig traumatisk skade inden for 28 dage før undersøgelsesregistrering og skal være helt kommet sig fra en sådan procedure
- Følgende anses ikke for at være større procedurer: thoracentese, paracentese, portplacering, laparoskopi, thoracoskopi, bronkoskopi, endoskopiske ultralydsprocedurer, mediastinoskopi, hudbiopsier, incisionsbiopsier og rutinemæssige tandprocedurer
Patienter må ikke forvente behov for et større kirurgisk indgreb i løbet af undersøgelsen
Der er ingen begrænsninger på kernebiopsier, placering af en vaskulær adgangsenhed eller andre mindre procedurer før registrering
- Anbringelse af en vaskulær adgangsanordning efter start af undersøgelsesterapi bør udføres mellem dag 15 og 28 i en behandlingscyklus (men ikke mindre end 48 timer før den næste dosis af bevacizumab) for at muliggøre tilstrækkelig heling
Patienter skal have målbar sygdom (mållæsioner): målbar sygdom defineres som mindst én læsion, der nøjagtigt kan måles i mindst én dimension (længste diameter, der skal registreres) som >= 2,0 cm med konventionelle teknikker eller som >= 1 cm med spiral computertomografi (CT) scanning
- Læsioner, der anses for ikke-målbare, omfatter følgende:
  - Knoglelæsioner
  - Leptomeningeal sygdom
  - Ascites
  - Pleural/pericardial effusion
  - Inflammatorisk brystsygdom
  - Lymphangitis cutis/pulmonitis
  - Abdominale masser, der ikke er bekræftet og efterfulgt af billedbehandlingsteknikker
  - Cystiske læsioner
Patienter med allerede eksisterende perifer neuropati >= grad 2 er ikke kvalificerede til denne undersøgelse
Patienter skal have en Eastern Cooperative Oncology Group (ECOG) (Zubrod) præstationsstatus på =< 1 for at være berettiget til dette forsøg
Kvinder må ikke være gravide eller amme; præmenopausale kvinder skal have et negativt serum eller urin beta-humant choriongonadotropin (Hcg)
Patienter med en anamnese med Common Terminology Criteria for Adverse Events (CTCAE) grad >= 3 overfølsomhed over for paclitaxel eller Cremophor® EL er ikke kvalificerede
Patienter med en anamnese med abdominal fistel eller intraabdominal absces inden for 6 måneder før undersøgelsesregistrering er ikke kvalificerede
Patienter med en anamnese med gastrointestinal (GI) perforation inden for 12 måneder før registrering er ikke kvalificerede
Patienter med en anamnese med betydelige blødningsepisoder (f.eks. hæmotyse, øvre eller nedre GI-blødning) inden for 6 måneder før registrering er ikke kvalificerede
Patienter må ikke have en historie med klinisk signifikant kardiovaskulær sygdom, der omfatter følgende:
- Ukontrolleret hypertension defineret som systolisk blodtryk > 150 og/eller diastolisk blodtryk > 90 mmHg på antihypertensiv medicin eller enhver tidligere historie med hypertensiv krise eller hypertensiv encefalopati
- Anamnese med myokardieinfarkt eller ustabil angina inden for de seneste 6 måneder
- New York Heart Association (NYHA) kongestiv hjertesvigt grad 2 eller højere
- Symptomatisk perifer vaskulær sygdom
- Betydelig vaskulær sygdom (f.eks. aortaaneurisme, aortadissektion) eller arterielle trombotiske hændelser
Patienter i fuld dosis antikoagulantia skal have en stabil dosis warfarin eller have en stabil dosis af lavmolekylært heparin (LMW); patienter, der får anti-blodplader eller i daglig profylaktisk dosis aspirin er kvalificerede, ligesom patienter, der får stabile doser af antikoagulering for atrieflimren
Patienter har muligvis ikke en historie med slagtilfælde eller forbigående iskæmisk anfald inden for 6 måneder før undersøgelsesregistrering
Patienter med en historie med anfald skal kontrolleres godt med standardmedicin
Patienter må ikke have progredierende eller ubehandlede metastaser i centralnervesystemet (CNS) eller leptomeningeal sygdom; patienter med en anamnese med resekerede hjernemetastaser med stabil magnetisk resonansbilleddannelse (MRI)-scanninger i 3 måneder inklusive inden for 4 uger efter studiestart er kvalificerede; patienter med en historie med gammakniv-strålekirurgi eller helhjerne-stråling med stabile MR-scanninger i 3 måneder, inklusive inden for 4 uger efter studiestart, er berettigede
Ingen alvorlige, ikke-helende sår, mavesår eller knoglebrud
Forventet levetid på >= 12 uger
Granulocytter >= 1.500/ul
Blodpladetal >= 100.000/ul
Kreatinin =< 2,0 mg/dL
Bilirubin < 1,5 mg/dL (medmindre det skyldes Gilberts syndrom)
Transaminaser (aspartataminotransferase [AST], alaninaminotransferase [ALT]) =< 2,5 x øvre normalgrænse (ULN)
Serum eller urin beta-Hcg negativ hos præmenopausale kvinder i den fødedygtige alder
Urinprotein =< 1+ protein* eller urinprotein: kreatininforhold (UPC) < 1
- Patienter, der opdages at have >= 2+ proteinuri ved baseline, skal gennemgå en 24-timers urinopsamling, der skal demonstrere < 1 g protein/24 timer eller UPC-forhold =< 1 for at tillade deltagelse i undersøgelsen

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Aktiv komparator: Arm A (Paclitaxel) Patienterne får 90 mg/m^2 paclitaxel IV over 1 time på dag 1, 8 og 15. Patienter kan få 10 mg/kg bevacizumab IV over 30-90 minutter på dag 1 og 15.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Spørgeskemaadministration Hjælpestudier Medicin: Paclitaxel Givet IV Andre navne: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Biologisk: Bevacizumab Givet IV Andre navne: Avastin ABP 215 Anti-VEGF Anti-VEGF humaniseret monoklonalt antistof Anti-VEGF monoklonalt antistof SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer Mvasi MYL-1402O Rekombinant humaniseret anti-VEGF monoklonalt antistof rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev
Eksperimentel: Arm B (Nab-paclitaxel) Patienter modtager paclitaxel albumin-stabiliseret nanopartikelformulering IV over 30 minutter på dag 1, 8 og 15. Patienter kan også modtage 10 mg/kg bevacizumab IV over 30-90 minutter på dag 1 og 15.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Spørgeskemaadministration Hjælpestudier Medicin: Nab-paclitaxel Givet IV Andre navne: ABI-007 Abraxane Albumin-bundet Paclitaxel ABI 007 Albumin-stabiliseret nanopartikel Paclitaxel Nanopartikel Albumin-bundet Paclitaxel Nanopartikel Paclitaxel Paclitaxel Albumin paclitaxel albumin-stabiliseret nanopartikelformulering Proteinbundet Paclitaxel Biologisk: Bevacizumab Givet IV Andre navne: Avastin ABP 215 Anti-VEGF Anti-VEGF humaniseret monoklonalt antistof Anti-VEGF monoklonalt antistof SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer Mvasi MYL-1402O Rekombinant humaniseret anti-VEGF monoklonalt antistof rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev
Eksperimentel: Arm C (Ixabepilone) Patienterne får ixabepilone IV over 60 minutter på dag 1, 8 og 15. Patienter kan også modtage 10 mg/kg bevacizumab IV over 30-90 minutter på dag 1 og 15. (lukket for optjening pr. 18/7/11)	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Spørgeskemaadministration Hjælpestudier Biologisk: Bevacizumab Givet IV Andre navne: Avastin ABP 215 Anti-VEGF Anti-VEGF humaniseret monoklonalt antistof Anti-VEGF monoklonalt antistof SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer Mvasi MYL-1402O Rekombinant humaniseret anti-VEGF monoklonalt antistof rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev Medicin: Ixabepilone Givet IV Andre navne: BMS-247550 Ixempra (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2- methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecan-5,9-dion Azaepothilone B BMS 247550 BMS247550 Epothilone Epothilone-B BMS 247550

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Progressionsfri overlevelse Tidsramme: Tid fra randomisering til progression eller død på grund af enhver årsag, alt efter hvad der indtræffer først (op til 5 år)	Progressionsfri overlevelse (PFS) er defineret som intervallet fra registrering til første sygdomsprogression, uanset stedet, eller dødsfald som følge af en hvilken som helst årsag, som nogensinde indtraf først. Fordelingen blev estimeret ved hjælp af Kaplan Meier-produktgrænsemetoden. Progression er defineret som en stigning på 20 % i summen af mållæsioners længste diameter (pr. responsevalueringskriterier i solide tumorer [RECIST]-kriterier).	Tid fra randomisering til progression eller død på grund af enhver årsag, alt efter hvad der indtræffer først (op til 5 år)

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Objektiv tumorresponsrate Tidsramme: Op til 5 år	Respons blev defineret af responsevalueringskriterierne i solide tumorer (RECIST). En responderende deltager havde enten en komplet respons (forsvinden af alle mållæsioner) eller delvis respons (30 % fald i summen af mållæsioners længste diameter).	Op til 5 år
Tid til behandlingsfejl Tidsramme: Tid fra randomisering til progression, død eller årlig afbrydelse af protokolterapi (op til 5 år)	Tid fra registrering til behandlingssvigt, defineret som tidlig afbrydelse af protokolbehandling uanset årsag, første sygdomsprogression eller død uden progression. Overlevende deltagere, der var fejlfrie, blev censureret som dato sidst kendt i live og fejlfri. Fordelingen blev estimeret ved hjælp af Kaplan Meier-produktgrænsemetoden.	Tid fra randomisering til progression, død eller årlig afbrydelse af protokolterapi (op til 5 år)
12 måneders progressionsfri overlevelse Tidsramme: 12 måneder	Procentdel af deltagere, der var i live og progressionsfri efter 12 måneder. Den 12 måneders progressionsfri overlevelse med 95 % konfidensinterval blev estimeret ved hjælp af Kaplan Meier-metoden.	12 måneder
Samlet overlevelse Tidsramme: Tid fra randomisering til død eller sidste opfølgning (op til 5 år)	Samlet overlevelse blev målt som intervallet fra studiestart til død, uanset årsag eller sidste kontakt. Fordelingen blev estimeret ved hjælp af Kaplan Meier-produktgrænsemetoden.	Tid fra randomisering til død eller sidste opfølgning (op til 5 år)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Hope S Rugo, Alliance for Clinical Trials in Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive."

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

13. oktober 2008

Primær færdiggørelse (Faktiske)

31. december 2013

Studieafslutning (Faktiske)

15. juni 2017

Datoer for studieregistrering

Først indsendt

4. november 2008

Først indsendt, der opfyldte QC-kriterier

4. november 2008

Først opslået (Skøn)

5. november 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

10. oktober 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

6. oktober 2022

Sidst verificeret

1. oktober 2022

Mere information

Begreber relateret til denne undersøgelse

Andre undersøgelses-id-numre

NCI-2009-00476 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180821 (U.S. NIH-bevilling/kontrakt)
U10CA031946 (U.S. NIH-bevilling/kontrakt)
CTSU 40502
CDR0000617539
NCCTG N063H
CALGB-40502 (Anden identifikator: CTEP)
PCALGB-40502_A11PAMDREVW01
CALGB 40502 (Anden identifikator: Alliance for Clinical Trials in Oncology)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Tilbagevendende brystkarcinom

Cairo University

Ikke rekrutterer endnu

Gyldighed og pålidelighed af arabisk version af brystspørgeskema

BREAST-Q
Abouqir General Hospital
Alexandria University

Rekruttering

Øjeblikkelig brystrekonstruktion med hybrid fedtoverførsel

Breast Udseende Rekonstruktion Disproportion

Egypten
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Cisplatin og gemcitabinhydrochlorid med eller uden berzosertib til behandling af patienter med metastatisk urothelial cancer

Metastatisk blæreurothelial karcinom | Metastatisk Ureter Urothelial Carcinoma | Stadie IV Blære Urothelial Carcinoma AJCC v7 | Metastatisk nyrebækken og Ureter Urothelial Carcinoma

Forenede Stater
Tianjin Medical University Cancer Institute and...
Guangxi Medical University; Sun Yat-sen University; Chinese PLA General Hospital og andre samarbejdspartnere

Afsluttet

De tekniske operationer og standard klinisk anvendelsesprotokol for CBBCT i diagnostisk proces af brystkræft (CBBCT)

Den kliniske anvendelsesvejledning af Conebeam Breast CT

Kina
ETOP IBCSG Partners Foundation

Afsluttet

Forsøg om den endokrine aktivitet af Neoadjuvant Degarelix (TREND)

Breast Cancer Invasive Nos

Italien
Spanish Breast Cancer Research Group
Hoffmann-La Roche; Roche Farma, S.A

Afsluttet

A Combined GWAS and miRNA for the Identification of Bevacizumab Response Predictors in Metastatic Breast Cancer

Breast Cancer Invasive Nos

Spanien
Ontario Clinical Oncology Group (OCOG)

Afsluttet

Blodiltniveauafhængig magnetisk resonansbilleddannelse (BOLD MRI) og Fluorothymidine Positron Emission Tomography (FLT PET) hos patienter med lokalt avanceret brystkræft, der gennemgår neoadjuverende kemoterapi (IMPACT)

Locally Advanced Breast Cancer (LABC)

Canada
Pomeranian Medical University Szczecin
Maria Sklodowska-Curie National Research Institute of Oncology; Regional...

Ukendt

Cisplatin-monotherapy in the Treatment of BRCA1 Positive Breast Cancer Patients in Poland

BRCA1 mutation | Breast Cancer Invasive Nos

Polen
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Aktiv, ikke rekrutterende

Forsøger at finde den korrekte behandlingslængde med immunkontrolpunktterapi (IMAGINE)

Metastatisk blæreurothelial karcinom | Metastatisk nyrebækken Urothelial Carcinom | Metastatisk Ureter Urothelial Carcinoma | Metastatisk Urethral Urothelial Carcinoma | Metastatisk Urothelial Carcinom | Lokalt avanceret blæreurothelial karcinom | Lokalt avanceret nyrebækken Urothelial Carcinoma | Lokalt... og andre forhold

Forenede Stater
Roswell Park Cancer Institute
Iovance Biotherapeutics, Inc.

Trukket tilbage

Adoptiv celleterapi med (LN-145) i kombination med Pembrolizumab til behandling af patienter med inoperabel eller metastatisk overgangscellekræft, som har fejlet Cisplatin-baseret kemoterapi

Metastatisk blæreurothelial karcinom | Metastatisk nyrebækken Urothelial Carcinom | Metastatisk Ureter Urothelial Carcinoma | Metastatisk Urethral Urothelial Carcinoma | Uoperabelt nyrebækken Urothelial Carcinom | Uoperabelt Ureter Urothelial Carcinoma

Forenede Stater

Kliniske forsøg med Laboratoriebiomarkøranalyse

Liao Jian An

Rekruttering

Meridianenergiændringer hos patienter med hoved- og nakkekræft efter kemoterapi eller strålebehandling

Hoved- og halskræft

Taiwan
Fondation Lenval

Trukket tilbage

Indflydelse af træthed på gangmønsteret hos patienter med cerebral parese.

Cerebral Parese

Frankrig
Progenity, Inc.

Afsluttet

Udvidet ikke-invasiv genomisk medicinsk vurdering: Enigma-undersøgelsen

Downs syndrom | Aneuploidi | DiGeorges syndrom | Turners syndrom | Klinefelters syndrom | Kromosom sletning | Edwards syndrom | Patau syndrom

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Biomarkørers baner for tidlig intervention hos søskende til børn med autismespektrumforstyrrelse

Autismespektrumforstyrrelse | Tidlig indsats

Italien
Oregon Health and Science University
4DMedical

Tilmelding efter invitation

Ventilationsubalancer ved let til moderat kronisk obstruktiv lungesygdom (VAPOR)

Lungesygdomme | KOL | Luftvejssygdom | Dyspnø

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Bekræft præstationen i klinisk praksis af den fordybende Virtual Reality Platform GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral Parese | Erhvervet hjerneskade

Italien
Modarres Hospital

Afsluttet

Renal parenkymal kernenålbiopsi

Komplikationer | Billedstyret biopsi | Nyre Glomerulus

Iran, Islamisk Republik
Healthy.io Ltd.

Afsluttet

[Prøvning af enhed, der ikke er godkendt eller godkendt af U.S. FDA]

Albuminuri

Forenede Stater
Medwave Estudios Limitada
Asociación Chilena de Seguridad

Ukendt

Diagnostisk værdi af arbejdsbelastningsanalyseinstrument til at påvise erhvervsmæssige risici ved muskel- og skelettilstande i øvre lemmer (ACT-ACHS)

Erhvervsmæssig eksponering | Muskuloskeletal sygdom

Chile
Duke University

Trukket tilbage

Point of Care-test for at forbedre overvågningen af LVAD-patienter

Antikoagulation og trombose Point of Care Test (AT-POCT)

Forenede Stater

Paclitaxel, Nab-paclitaxel eller Ixabepilone med eller uden Bevacizumab til behandling af patienter med stadium IIIC eller stadium IV brystkræft

Et randomiseret fase III-forsøg med ugentlig paclitaxel sammenlignet med ugentlig nanopartikelalbumin bundet Nab-paclitaxel eller Ixabepilon med eller uden bevacizumab som førstelinjebehandling for lokalt tilbagevendende eller metastatisk brystkræft

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

produkt fremstillet i og eksporteret fra U.S.A.

Kliniske forsøg med Tilbagevendende brystkarcinom

Kliniske forsøg med Laboratoriebiomarkøranalyse

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Albania

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer