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Bækkenstrålebehandling eller vaginalt implantat strålebehandling, paclitaxel og carboplatin til behandling af patienter med højrisikostadie I eller stadium II endometriecancer

8. marts 2019 opdateret af: Gynecologic Oncology Group

Et fase III forsøg med bækkenstrålebehandling versus vaginal cuff brachyterapi efterfulgt af Paclitaxel/Carboplatin kemoterapi hos patienter med højrisiko, tidligt stadium endometriecarcinom

Dette randomiserede fase III-forsøg studerer bækkenstrålebehandling for at se, hvor godt det virker sammenlignet med vaginal implantatstrålebehandling, paclitaxel og carboplatin til behandling af patienter med højrisikostadie I eller stadium II endometriecancer. Strålebehandling bruger højenergi røntgenstråler til at dræbe tumorceller. Implantatstrålebehandling bruger radioaktivt materiale placeret direkte i eller nær en tumor for at dræbe tumorceller. Lægemidler brugt i kemoterapi, såsom paclitaxel og carboplatin, virker på forskellige måder for at stoppe væksten af ​​tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Det vides endnu ikke, om bækkenstrålebehandling alene er mere effektiv end strålebehandling med vaginale implantater, paclitaxel og carboplatin til behandling af patienter med endometriecancer.

Studieoversigt

Status

Ukendt

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. For at afgøre, om behandling med vaginal manchet brachyterapi efterfulgt af tre cyklusser af kemoterapi reducerer frekvensen af ​​tilbagefald eller død (dvs. øger gentagelsesfri overlevelse) sammenlignet med bækkenstrålebehandling.

SEKUNDÆRE MÅL:

I. At sammenligne overlevelse mellem de to behandlingsgrupper. II. At sammenligne mønstre for svigt mellem de to behandlingsgrupper. III. At sammenligne fysisk funktion, træthed og neurotoksicitet mellem de to behandlingsgrupper.

IV. At undersøge sammenhænge mellem primære komorbide sygdomme og fedme på overlevelse, træthed og fysisk funktionsevne.

V. At evaluere de psykometriske egenskaber (såsom konstruktionsvaliditet, reliabilitet, følsomhed over for behandling og reaktionsevne over tid) af Patient-Reported-Outcomes Measurement Information System (PROMIS) Fatigue Short form 1, og at evaluere træthedsmålingsækvivalens mellem kvinder med endometriecancer og aldersmatchede kvinder fra den generelle befolkning i USA (USA).

TERTIÆRE MÅL:

I. At evaluere evnen af ​​genekspressionssignaturer i tidlig stadium endometriecancer til at forudsige recidiv og at udforske sammenhængen mellem genekspressionssignaturer i tidlig stadium endometriecancer og kliniske karakteristika og resultat.

II. At banke fuldblodsprøver til fremtidig forskning.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM I: Patienter gennemgår konventionel eller intensitetsmoduleret bækkenstrålebehandling én gang dagligt, 5 dage om ugen, i 5-6 uger (i alt 25-28 fraktioner) i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter med stadium II sygdom eller stadium I sygdom med en bekræftet diagnose af klarcellet og/eller papillær serøs histologi kan også gennemgå 1 eller 2 intravaginale (dvs. vaginal cuff) brachyterapi boost-behandlinger.

ARM II: Patienter gennemgår vaginal manchet brachyterapi omfattende 3-5 højdosis brachyterapibehandlinger over ca. 2 uger eller 1 eller 2 lavdosis brachyterapibehandlinger over 1-2 dage. Begyndende inden for 3 uger efter påbegyndelse af brachyterapi, får patienterne paclitaxel intravenøst ​​(IV) over 3 timer og carboplatin IV over 30-60 minutter på dag 1. Kemoterapi gentages hver 21. dag i op til 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne op hver 3. måned i 2 år, hver 6. måned i 3 år og derefter årligt derefter i op til 5 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

601

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • University of Alabama at Birmingham Cancer Center
      • Mobile, Alabama, Forenede Stater, 36688
        • University of South Alabama Mitchell Cancer Institute
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Providence Alaska Medical Center
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85013
        • Saint Joseph's Hospital and Medical Center
      • Tucson, Arizona, Forenede Stater, 85719
        • University of Arizona Cancer Center-North Campus
      • Tucson, Arizona, Forenede Stater, 85704
        • Arizona Oncology Associates-West Orange Grove
    • California
      • Auburn, California, Forenede Stater, 95603
        • Sutter Cancer Centers Radiation Oncology Services-Auburn
      • Burbank, California, Forenede Stater, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Cameron Park, California, Forenede Stater, 95682
        • Sutter Cancer Centers Radiation Oncology Services-Cameron Park
      • Carmichael, California, Forenede Stater, 95608
        • Mercy San Juan Medical Center
      • Concord, California, Forenede Stater, 94520
        • John Muir Medical Center-Concord Campus
      • La Jolla, California, Forenede Stater, 92093
        • UC San Diego Moores Cancer Center
      • Long Beach, California, Forenede Stater, 90806
        • Long Beach Memorial Medical Center-Todd Cancer Institute
      • Los Angeles, California, Forenede Stater, 90095
        • UCLA / Jonsson Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars Sinai Medical Center
      • Modesto, California, Forenede Stater, 95355
        • Memorial Medical Center
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Gynecologic Oncology
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Oakland-Broadway
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Orange, California, Forenede Stater, 92868
        • Saint Joseph Hospital - Orange
      • Palo Alto, California, Forenede Stater, 94304
        • Stanford Cancer Institute Palo Alto
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Rohnert Park, California, Forenede Stater, 94928
        • Rohnert Park Cancer Center
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Cancer Centers Radiation Oncology Services-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Roseville Medical Center
      • Sacramento, California, Forenede Stater, 95816
        • Sutter Medical Center Sacramento
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • Sacramento, California, Forenede Stater, 95819
        • Mercy General Hospital Radiation Oncology Center
      • San Diego, California, Forenede Stater, 92103
        • University of California San Diego
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94115
        • UCSF Medical Center-Mount Zion
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Sylmar, California, Forenede Stater, 91342
        • Olive View-University of California Los Angeles Medical Center
      • Vacaville, California, Forenede Stater, 95687
        • Sutter Cancer Centers Radiation Oncology Services-Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Walnut Creek, California, Forenede Stater, 94598
        • John Muir Medical Center-Walnut Creek
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • University Of Colorado Hospital
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Aurora, Colorado, Forenede Stater, 80010
        • Colorado Gynecologic Oncology Group
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80222
        • Colorado Cancer Research Program NCORP
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Grand Junction, Colorado, Forenede Stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forenede Stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forenede Stater, 80138
        • Parker Adventist Hospital
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, Forenede Stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Bridgeport, Connecticut, Forenede Stater, 06606
        • Saint Vincent's Medical Center
      • Danbury, Connecticut, Forenede Stater, 06810
        • Danbury Hospital
      • Farmington, Connecticut, Forenede Stater, 06030
        • University of Connecticut
      • Hartford, Connecticut, Forenede Stater, 06102
        • Hartford Hospital
      • New Britain, Connecticut, Forenede Stater, 06050
        • The Hospital of Central Connecticut
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • Norwich, Connecticut, Forenede Stater, 06360
        • Eastern Connecticut Hematology and Oncology Associates
      • Norwich, Connecticut, Forenede Stater, 06360
        • William Backus Hospital
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20010
        • MedStar Washington Hospital Center
      • Washington, District of Columbia, Forenede Stater, 20016
        • Sibley Memorial Hospital
    • Florida
      • Clearwater, Florida, Forenede Stater, 33756
        • Morton Plant Hospital
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Fort Myers, Florida, Forenede Stater, 33905
        • Florida Gynecologic Oncology
      • Jacksonville, Florida, Forenede Stater, 32204
        • Southeast Gynecologic Oncology Associates
      • Miami, Florida, Forenede Stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
      • Orlando, Florida, Forenede Stater, 32806
        • UF Cancer Center at Orlando Health
      • Orlando, Florida, Forenede Stater, 32806
        • Florida Institute of Research Medicine and Surgery-Cancer Center
      • Saint Petersburg, Florida, Forenede Stater, 33701
        • Women's Cancer Associates
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Forenede Stater, 30303
        • Grady Health System
      • Atlanta, Georgia, Forenede Stater, 30342
        • Northside Hospital
      • Augusta, Georgia, Forenede Stater, 30912
        • Augusta University Medical Center
      • Columbus, Georgia, Forenede Stater, 31904
        • John B Amos Cancer Center
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Macon, Georgia, Forenede Stater, 31201
        • Central Georgia Gynecologic Oncology
      • Savannah, Georgia, Forenede Stater, 31404
        • Memorial Health University Medical Center
    • Hawaii
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • The Cancer Center of Hawaii-Pali Momi
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Oncology Inc-Kuakini
      • Lihue, Hawaii, Forenede Stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • Wailuku, Hawaii, Forenede Stater, 96793
        • Maui Memorial Medical Center
    • Idaho
      • Boise, Idaho, Forenede Stater, 83712
        • Saint Luke's Mountain States Tumor Institute
      • Fruitland, Idaho, Forenede Stater, 83619
        • Saint Luke's Mountain States Tumor Institute - Fruitland
      • Meridian, Idaho, Forenede Stater, 83642
        • Saint Luke's Mountain States Tumor Institute - Meridian
      • Nampa, Idaho, Forenede Stater, 83686
        • Saint Luke's Mountain States Tumor Institute - Nampa
      • Twin Falls, Idaho, Forenede Stater, 83301
        • Saint Luke's Mountain States Tumor Institute-Twin Falls
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Saint Anthony's Health
      • Bloomington, Illinois, Forenede Stater, 61701
        • Saint Joseph Medical Center
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush University Medical Center
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60612
        • John H Stroger Jr Hospital of Cook County
      • Decatur, Illinois, Forenede Stater, 62526
        • Heartland Cancer Research NCORP
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Western Illinois Cancer Treatment Center
      • Hinsdale, Illinois, Forenede Stater, 60521
        • Hinsdale Hematology Oncology Associates Incorporated
      • Hinsdale, Illinois, Forenede Stater, 60521
        • Sudarshan K Sharma MD Limited-Gynecologic Oncology
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center Foundation
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Forenede Stater, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Advocate Lutheran General Hospital
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peru, Illinois, Forenede Stater, 61354
        • Valley Radiation Oncology
      • Rockford, Illinois, Forenede Stater, 61104
        • Swedish American Hospital
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Winfield, Illinois, Forenede Stater, 60190
        • Northwestern Medicine Central DuPage Hospital
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • Franciscan Saint Francis Health-Beech Grove
      • Dyer, Indiana, Forenede Stater, 46311
        • Franciscan Saint Margaret Health-Dyer Campus
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, Forenede Stater, 46805
        • Parkview Hospital Randallia
      • Fort Wayne, Indiana, Forenede Stater, 46804
        • Radiation Oncology Associates PC
      • Hammond, Indiana, Forenede Stater, 46320
        • Franciscan Saint Margaret Health-Hammond Campus
      • Indianapolis, Indiana, Forenede Stater, 46237
        • Franciscan Health Indianapolis
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46260
        • Saint Vincent Hospital and Health Care Center
      • Indianapolis, Indiana, Forenede Stater, 46219
        • IU Health Central Indiana Cancer Centers-East
      • Kokomo, Indiana, Forenede Stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forenede Stater, 46350
        • IU Health La Porte Hospital
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Munster, Indiana, Forenede Stater, 46321
        • The Community Hospital
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Health
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, Forenede Stater, 46628
        • Northern Indiana Cancer Research Consortium
      • South Bend, Indiana, Forenede Stater, 46617
        • South Bend Clinic
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC - Ames
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Medical Center - North Iowa
    • Kansas
      • Anthony, Kansas, Forenede Stater, 67003
        • Hospital District Sixth of Harper County
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • Liberal, Kansas, Forenede Stater, 67901
        • Southwest Medical Center
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • Kansas City NCI Community Oncology Research Program
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67214
        • Wesley Medical Center
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Edgewood, Kentucky, Forenede Stater, 41017
        • Saint Elizabeth Medical Center South
      • Lexington, Kentucky, Forenede Stater, 40536
        • University of Kentucky/Markey Cancer Center
      • Lexington, Kentucky, Forenede Stater, 40503
        • Baptist Health Lexington
      • Louisville, Kentucky, Forenede Stater, 40202
        • The James Graham Brown Cancer Center at University of Louisville
      • Pikeville, Kentucky, Forenede Stater, 41501
        • Pikeville Medical Center
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70817
        • Woman's Hospital
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
      • Shreveport, Louisiana, Forenede Stater, 71103
        • Louisiana State University Health Sciences Center Shreveport
    • Maine
      • Portland, Maine, Forenede Stater, 04102
        • Maine Medical Center-Bramhall Campus
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21237
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
      • Baltimore, Maryland, Forenede Stater, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, Forenede Stater, 21204
        • Greater Baltimore Medical Center
      • Baltimore, Maryland, Forenede Stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21229
        • Saint Agnes Hospital
      • Bethesda, Maryland, Forenede Stater, 20889-5600
        • Walter Reed National Military Medical Center
      • Elkton, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02111
        • Tufts Medical Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Hospital and Medical Center
      • Worcester, Massachusetts, Forenede Stater, 01655
        • University of Massachusetts Medical School
      • Worcester, Massachusetts, Forenede Stater, 01605
        • University of Massachusetts Memorial Health Care
    • Michigan
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Spectrum Health Big Rapids Hospital
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49048
        • Borgess Medical Center
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Niles, Michigan, Forenede Stater, 49120
        • Lakeland Hospital Niles
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Medical Center Saint Joseph
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • University of Minnesota/Masonic Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55426
        • Park Nicollet Frauenshuh Cancer Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • University of Mississippi Medical Center
      • Pascagoula, Mississippi, Forenede Stater, 39581
        • Singing River Hospital
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Kansas City, Missouri, Forenede Stater, 64154
        • The University of Kansas Cancer Center-North
      • Kansas City, Missouri, Forenede Stater, 64114
        • Saint Joseph Health Center
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Radiation Oncology Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Saint Joseph Oncology Inc
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Heartland Regional Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Saint Louis-Cape Girardeau CCOP
      • Springfield, Missouri, Forenede Stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59102
        • Montana Cancer Consortium NCORP
      • Billings, Montana, Forenede Stater, 59101
        • Northern Rockies Radiation Oncology Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, Forenede Stater, 59405
        • Berdeaux, Donald MD (UIA Investigator)
    • Nebraska
      • Omaha, Nebraska, Forenede Stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Nevada Cancer Research Foundation CCOP
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Women's Cancer Center of Nevada
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89502
        • Center of Hope at Renown Medical Center
    • New Hampshire
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Elliot Hospital
    • New Jersey
      • Camden, New Jersey, Forenede Stater, 08103
        • Cooper Hospital University Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Hackensack University Medical Center
      • Livingston, New Jersey, Forenede Stater, 07039
        • Saint Barnabas Medical Center
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Monmouth Medical Center
      • Morristown, New Jersey, Forenede Stater, 07960
        • Morristown Medical Center
      • Mount Holly, New Jersey, Forenede Stater, 08060
        • Virtua Memorial
      • Neptune, New Jersey, Forenede Stater, 07753
        • Jersey Shore Medical Center
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
      • Newark, New Jersey, Forenede Stater, 07101
        • Rutgers New Jersey Medical School
      • Phillipsburg, New Jersey, Forenede Stater, 08865
        • Saint Luke's Hospital-Warren Campus
      • Ridgewood, New Jersey, Forenede Stater, 07450
        • Valley Hospital
      • Summit, New Jersey, Forenede Stater, 07902
        • Overlook Hospital
      • Toms River, New Jersey, Forenede Stater, 08755
        • Community Medical Center
      • Vineland, New Jersey, Forenede Stater, 08360
        • Inspira Medical Center Vineland
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Virtua Voorhees
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Southwest Gynecologic Oncology Associates Inc
      • Las Cruces, New Mexico, Forenede Stater, 88011
        • Memorial Medical Center - Las Cruces
    • New York
      • Albany, New York, Forenede Stater, 12208
        • Women's Cancer Care Associates LLC
      • Brightwaters, New York, Forenede Stater, 11718
        • Island Gynecologic Oncology
      • Brooklyn, New York, Forenede Stater, 11203
        • State University of New York Downstate Medical Center
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Canandaigua, New York, Forenede Stater, 14424
        • Sands Cancer Center
      • Fresh Meadows, New York, Forenede Stater, 11365
        • New York Hospital Medical Center of Queens
      • Lake Success, New York, Forenede Stater, 11042
        • Northwell Health NCORP
      • Lake Success, New York, Forenede Stater, 11042
        • Northwell Health/Center for Advanced Medicine
      • Manhasset, New York, Forenede Stater, 11030
        • North Shore University Hospital
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • Mineola, New York, Forenede Stater, 11501
        • NYU Winthrop Hospital
      • New Hyde Park, New York, Forenede Stater, 11040
        • Long Island Jewish Medical Center
      • New York, New York, Forenede Stater, 10065
        • Memorial Sloan Kettering Cancer Center
      • New York, New York, Forenede Stater, 10019
        • Mount Sinai West
      • New York, New York, Forenede Stater, 10029
        • Mount Sinai Hospital
      • New York, New York, Forenede Stater, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
      • New York, New York, Forenede Stater, 10016
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
      • New York, New York, Forenede Stater, 10003
        • Mount Sinai Union Square
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Rochester, New York, Forenede Stater, 14620
        • Highland Hospital
      • Rochester, New York, Forenede Stater, 14626
        • University Radiation Oncology
      • Stony Brook, New York, Forenede Stater, 11794
        • Stony Brook University Medical Center
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203
        • Randolph Hospital
      • Asheville, North Carolina, Forenede Stater, 28816
        • Hope Women's Cancer Centers-Asheville
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Presbyterian Medical Center
      • Concord, North Carolina, Forenede Stater, 28025
        • Atrium Health Cabarrus/LCI-Concord
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Greensboro, North Carolina, Forenede Stater, 27403
        • Cone Health Cancer Center
      • Raleigh, North Carolina, Forenede Stater, 27609
        • Duke Raleigh Hospital
      • Raleigh, North Carolina, Forenede Stater, 27607
        • Duke Women's Cancer Care Raleigh
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Memorial Hospital
      • Rutherfordton, North Carolina, Forenede Stater, 28139
        • Rutherford Hospital
      • Wilmington, North Carolina, Forenede Stater, 28401
        • New Hanover Regional Medical Center/Zimmer Cancer Center
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forenede Stater, 27104
        • Southeast Clinical Oncology Research (SCOR) Consortium NCORP
    • North Dakota
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Clinic North-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Roger Maris Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • Cleveland Clinic Akron General
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Akron City Hospital/Cooper Cancer Center
      • Barberton, Ohio, Forenede Stater, 44203
        • Summa Barberton Hospital
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Health Foundation
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Oncology Hematology Care Inc-Blue Ash
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati/Barrett Cancer Center
      • Cleveland, Ohio, Forenede Stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forenede Stater, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Miami Valley Hospital North
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Mentor, Ohio, Forenede Stater, 44060
        • UH Seidman Cancer Center at Lake Health Mentor Campus
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Hospital
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Salem, Ohio, Forenede Stater, 44460
        • UH Seidman Cancer Center at Salem Regional Medical Center
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Wooster, Ohio, Forenede Stater, 44691
        • Cancer Treatment Center
      • Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
        • Wright-Patterson Medical Center
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
    • Oregon
      • Eugene, Oregon, Forenede Stater, 97401
        • Willamette Valley Cancer Center
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Compass Oncology Rose Quarter
      • Salem, Oregon, Forenede Stater, 97301
        • Salem Hospital
    • Pennsylvania
      • Abington, Pennsylvania, Forenede Stater, 19001
        • Abington Memorial Hospital
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18015
        • Saint Luke's University Hospital-Bethlehem Campus
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Hanover, Pennsylvania, Forenede Stater, 17331
        • Cherry Tree Cancer Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Lancaster, Pennsylvania, Forenede Stater, 17604
        • Lancaster General Hospital
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19140
        • Temple University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Pennsylvania Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Medical Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Main Line Health NCORP
      • York, Pennsylvania, Forenede Stater, 17403
        • WellSpan Health-York Cancer Center
      • York, Pennsylvania, Forenede Stater, 17403
        • WellSpan Health-York Hospital
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02905
        • Women and Infants Hospital
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Health Cancer Center
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Health Hospital
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forenede Stater, 29601
        • Greenville Health System Cancer Institute-Andrews
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Faris
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Memorial Hospital
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Butternut
      • Greer, South Carolina, Forenede Stater, 29650
        • Greenville Health System Cancer Institute-Greer
      • Seneca, South Carolina, Forenede Stater, 29672
        • Greenville Health System Cancer Institute-Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Greenville Health System Cancer Institute-Spartanburg
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Black Hills Obstetrics and Gynecology
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Chattanooga, Tennessee, Forenede Stater, 37403
        • Chattanooga's Program In Women's Oncology
      • Chattanooga, Tennessee, Forenede Stater, 37403
        • Chattanooga Gynecological Oncology
      • Knoxville, Tennessee, Forenede Stater, 37920
        • University of Tennessee - Knoxville
      • Nashville, Tennessee, Forenede Stater, 37232
        • Vanderbilt University/Ingram Cancer Center
      • Nashville, Tennessee, Forenede Stater, 37208
        • Meharry Medical College
      • Nashville, Tennessee, Forenede Stater, 37203
        • Tennessee Oncology PLLC- Centennial Medical Center
    • Texas
      • Arlington, Texas, Forenede Stater, 76014
        • Texas Oncology-Arlington South
      • Austin, Texas, Forenede Stater, 78705
        • Texas Oncology-Austin Midtown
      • Austin, Texas, Forenede Stater, 78731
        • Texas Oncology - Central Austin Cancer Center
      • Austin, Texas, Forenede Stater, 78745
        • Texas Oncology - South Austin Cancer Center
      • Bedford, Texas, Forenede Stater, 76022
        • Texas Oncology Bedford
      • Dallas, Texas, Forenede Stater, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Dallas, Texas, Forenede Stater, 75246
        • Baylor University Medical Center
      • Dallas, Texas, Forenede Stater, 75390
        • Clements University Hospital
      • Denton, Texas, Forenede Stater, 76210
        • Texas Oncology-Denton South
      • Fort Sam Houston, Texas, Forenede Stater, 78234
        • Brooke Army Medical Center
      • Fort Worth, Texas, Forenede Stater, 76104
        • Baylor All Saints Medical Center at Fort Worth
      • Fort Worth, Texas, Forenede Stater, 76104
        • The Klabzuba Cancer Center
      • Galveston, Texas, Forenede Stater, 77555-0565
        • University of Texas Medical Branch
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • The Methodist Hospital System
      • Houston, Texas, Forenede Stater, 77024
        • Memorial Hermann Memorial City Medical Center
      • Lackland Air Force Base, Texas, Forenede Stater, 78236
        • Wilford Hall Medical Center
      • Longview, Texas, Forenede Stater, 75601
        • Texas Oncology-Longview Cancer Center
      • Odessa, Texas, Forenede Stater, 79761
        • West Texas Cancer Center
      • Round Rock, Texas, Forenede Stater, 78681
        • Texas Oncology - Round Rock Cancer Center
      • Sherman, Texas, Forenede Stater, 75090
        • Texas Cancer Center-Sherman
      • Sugar Land, Texas, Forenede Stater, 77479
        • Texas Oncology Cancer Center Sugar Land
      • Tyler, Texas, Forenede Stater, 75702
        • Tyler Cancer Center
      • Wichita Falls, Texas, Forenede Stater, 76310
        • Texas Oncology-Wichita Falls Texoma Cancer Center
    • Utah
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L Maxwell Cancer Center
      • Murray, Utah, Forenede Stater, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Saint George, Utah, Forenede Stater, 84770
        • Dixie Medical Center Regional Cancer Center
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
      • Salt Lake City, Utah, Forenede Stater, 84103
        • Intermountain Health Care
    • Vermont
      • Burlington, Vermont, Forenede Stater, 05401
        • University of Vermont Medical Center
    • Virginia
      • Annandale, Virginia, Forenede Stater, 22003
        • Northern Virginia Pelvic Surgery Associates
      • Charlottesville, Virginia, Forenede Stater, 22908
        • University of Virginia Cancer Center
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
      • Roanoke, Virginia, Forenede Stater, 24016
        • Carilion Clinic Gynecological Oncology
    • Washington
      • Bellingham, Washington, Forenede Stater, 98226
        • PeaceHealth Medical Group PC
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison Medical Center
      • Everett, Washington, Forenede Stater, 98201
        • Providence Regional Cancer Partnership
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Valley Hospital Regional Cancer Care Center
      • Poulsbo, Washington, Forenede Stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98109
        • Seattle Cancer Care Alliance
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, Forenede Stater, 98112
        • Kaiser Permanente Washington
      • Seattle, Washington, Forenede Stater, 98104
        • Pacific Gynecology Specialists
      • Seattle, Washington, Forenede Stater, 98122-4307
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forenede Stater, 98133
        • Northwest Hospital
      • Sequim, Washington, Forenede Stater, 98384
        • Olympic Medical Cancer Care Center
      • Spokane, Washington, Forenede Stater, 99204
        • Rockwood Cancer Treatment Center-DHEC-Downtown
      • Spokane, Washington, Forenede Stater, 99202
        • Cancer Care Northwest - Spokane South
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • Saint Joseph Medical Center
      • Walla Walla, Washington, Forenede Stater, 99362
        • Providence Saint Mary Regional Cancer Center
      • Wenatchee, Washington, Forenede Stater, 98801
        • Wenatchee Valley Hospital and Clinics
      • Yakima, Washington, Forenede Stater, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
      • Yakima, Washington, Forenede Stater, 98902
        • Cancer Institutes of Washington PLLC
    • West Virginia
      • Wheeling, West Virginia, Forenede Stater, 26003
        • Wheeling Hospital/Schiffler Cancer Center
    • Wisconsin
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Hospital and Clinics
      • Mequon, Wisconsin, Forenede Stater, 53097
        • Columbia Saint Mary's Hospital - Ozaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Froedtert and The Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53211
        • Columbia Saint Mary's Water Tower Medical Commons
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53405
        • Wheaton Franciscan Cancer Care - All Saints
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
  • Korea, Republikken
      • Seoul, Korea, Republikken, 110-744
        • Seoul National University Hospital
      • Seoul, Korea, Republikken, 135-720
        • Gangnam Severance Hospital
      • Seoul, Korea, Republikken, 05505
        • Asan Medical Center
      • Seoul, Korea, Republikken, 139-706
        • Korea Cancer Center Hospital
      • Seoul, Korea, Republikken, 135-720
        • Yongdong Severence Hospital
      • Suwon, Korea, Republikken, 443-721
        • Ajou University Hospital
    • Incheon
      • Jung-gu, Incheon, Korea, Republikken, 400-711
        • Inha University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (VOKSEN, OLDER_ADULT)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Inklusionskriterier:

  • For at blive betragtet som kvalificeret til at deltage i dette forsøg skal alle patienter have gennemgået hysterektomi; bilateral salpingo-ooforektomi (åben eller laparoskopisk tilgang) tilskyndes kraftigt

  • Peritoneal cytologi bør opnås ved indtræden i bughulen, som beskrevet i Gynecologic Oncology Group (GOG) Surgical Procedures Manual (https://gogmember.gog.org/manuals/pdf/surgman.pdf); bækken- og paraaorta-lymfadenektomi er valgfri, men stærkt opfordret (da iscenesatte patienter, der er indskrevet på GOG-0210-molekylære markører i endometriekarcinom, er kvalificerede til denne undersøgelse)

    • Procedurerne kan udføres via laparotomi eller laparoskopi (herunder robotassisteret) efter kirurgens præference; kirurgen skal registrere i operationsrapporten, om der er udført en lymfadenektomi (se linket ovenfor til Surgical Procedures Manual) eller ej; et specifikt antal lymfeknuder, der er fjernet, vil ikke blive brugt til at være berettiget, men operationsrapporten bør afspejle, at den udførte procedure var i overensstemmelse med procedurerne beskrevet i GOG Surgical Manual
  • Hvis enten en bilateral salpingo-ooforektomi eller nodal dissektion ikke blev udført, er postoperativ forbehandling computertomografi (CT)/magnetisk resonansbilleddannelse (MRI) påkrævet og må ikke påvise beviser, der tyder på metastatisk sygdom (adnexa, noder, intraperitoneal sygdom ); postoperativ, før-behandling CT/MRI skal udføres, hvis en bækken og para-aorta nodal dissektion ikke blev udført

  • Med henblik på beskrivelsen vil patienterne blive iscenesat i henhold til International Federation of Gynecology and Obstetrics (FIGO) 2009 iscenesættelsessystem; berettigelse er defineret baseret på klinisk-patologiske træk; patienter med endometriecarcinom (endometrioidtyper) begrænset til corpus uteri eller med endocervikal kirtelinvolvering, der passer til en af ​​følgende høj-intermediære risikofaktorkategorier:

    • Alder >= 70 år med én risikofaktor
    • Alder >= 50 med 2 risikofaktorer
    • Alder >= 18 år med 3 risikofaktorer
    • Risikofaktorer: grad 2 eller 3 tumor, (+) lymfovaskulær ruminvasion, ydre ? myometrial invasion; patienter med disse risikokriterier kan indskrives med enten positiv eller negativ cytologi
  • Patienter med stadium II endometriecarcinom (enhver histologi) med cervikal stromal invasion (okkult eller grov involvering), med eller uden høj-intermediære risikofaktorer
  • Patienter med serøs eller klar celle histologi (med eller uden andre høj-intermediære risikofaktorer) er kvalificerede, forudsat at sygdommen er livmoderbegrænset (med eller uden cervikal stromal invasion eller endocervikal kirtel involvering) og med peritoneal cytologi negativ for malignitet
  • Patienter skal have GOG præstationsstatus 0, 1 eller 2
  • Absolut neutrofiltal (ANC) >= 1.500/mcl (svarende til almindelige toksicitetskriterier [CTCAE version [v] 3.0] grad 1)
  • Blodplader >= 100.000/mcl (CTCAE v3.0 grad 0-1)

  • Serumkreatinin =< institutionel øvre grænse normal (ULN), CTCAE v 3.0 grad 0

    • Bemærk: Hvis serumkreatinin > ULN, skal der indsamles en 24-timers kreatininclearance og skal være > 50 ml/min.
  • Bilirubin =< 1,5 x ULN (CTCAE v3.0 grad 1)
  • Serum glutaminsyre oxaloeddikesyretransaminase (SGOT) =< 2,5 x ULN (CTCAE grad 0-1)
  • Alkalisk fosfatase =< 2,5 x ULN (CTCAE grad 0-1)
  • Neuropati (sensorisk og motorisk) =< CTCAE v3.0 grad 1
  • Patienter, der har opfyldt før-adgangskravene; testværdier/resultater skal opfylde berettigelseskriterier
  • Patienter skal have underskrevet et godkendt informeret samtykke og autorisation, der tillader frigivelse af personlige helbredsoplysninger

Ekskluderingskriterier:

  • Patienter, der allerede har modtaget ikke-kirurgisk behandling for endometriecancer, herunder kemoterapi, stråling (eksempelvis præoperativ eller postoperativ brachyterapi), hormonbehandling eller biologisk behandling
  • Patienter identificeret med patologisk bekræftet spredning af cancer ud over livmoderen og livmoderhalsen til bækken- eller paraaorta-lymfeknuder, adnexale strukturer og/eller andre anatomiske steder, eller patienter med serøs eller klar cellehistologi og med positive cytologiske udvaskninger
  • Patienter med nodal (for patienter, der ikke fik udført nodal dissektion) eller fjern sygdom bestemt baseret på billeddiagnostiske undersøgelser; patienter med mistænkelige knuder, der er blevet biopsieret (genoptagelse af operation, finnålsaspiration [FNA]) og er patologisk negative vil være berettigede
  • Patienter med en anamnese med andre invasive maligniteter, med undtagelse af non-melanom hudcancer, udelukkes, hvis der er tegn på, at andre maligne sygdomme er til stede inden for de sidste 5 år; patienter udelukkes, hvis deres tidligere kræftbehandling kontraindikerer denne protokolbehandling; specifikt er patienter, der tidligere har modtaget strålebehandling rettet mod at behandle sygdom i bughulen eller bækkenet, udelukket
  • Forudgående stråling af lokaliseret kræft i bryst, hoved og hals, skjoldbruskkirtel eller hud er tilladt, forudsat at den er gennemført mere end 5 år før registreringen, og patienten forbliver fri for tilbagevendende eller metastatisk sygdom
  • Patienter kan have modtaget forudgående adjuverende kemoterapi for lokaliseret brystkræft, forudsat at den er afsluttet mere end 5 år før registreringen, og patienten forbliver fri for tilbagevendende eller metastatisk sygdom
  • Patienter, der har kontraindikationer til bækkenstrålebehandling (f.eks. bækkennyre, bindevævssygdom, inflammatorisk tarmsygdom osv.) bør screenes på forhånd og ikke anses for at være berettiget til forsøget
  • Patienter med tilbagevendende endometriecancer
  • Patienter med kirurgisk eller klinisk, FIGO 2009 stadium III eller IV endometriekarcinom
  • Patienter med ikke-epiteliale uterine maligniteter såsom livmodercarcinosarkom eller leiomyosarkom

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: BEHANDLING
  • Tildeling: TILFÆLDIGT
  • Interventionel model: PARALLEL
  • Maskning: INGEN

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
ACTIVE_COMPARATOR: Arm I (bækkenstrålebehandling)
Patienter gennemgår konventionel eller intensitetsmoduleret bækkenstrålebehandling én gang dagligt, 5 dage om ugen, i 5-6 uger (i alt 25-28 fraktioner) i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter med stadium II sygdom eller stadium I sygdom med en bekræftet diagnose af klarcellet og/eller papillær serøs histologi kan også gennemgå 1 eller 2 intravaginale (dvs. vaginal cuff) brachyterapi boost-behandlinger.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Andet: Spørgeskemaadministration
Hjælpestudier
Stråling: 3-dimensionel konform strålebehandling
Gennemgå bækkenstrålebehandling
Andre navne:
  • 3-dimensionel strålebehandling
  • 3D KONFORMAL STRÅLETERAPI
  • 3D CRT
  • 3D-CRT
  • Konform terapi
  • Stråling konform terapi
Stråling: Intensitetsmoduleret strålebehandling
Gennemgå bækkenstrålebehandling
Andre navne:
  • IMRT
  • Intensitetsmoduleret RT
  • Intensitetsmoduleret strålebehandling
Stråling: Intern Stråleterapi
Gennemgå vaginal manchet brachyterapi
Andre navne:
  • Intern strålings brachyterapi
  • Strålingsbrachyterapi
  • BRACHYTERAPI
  • indre stråling
EKSPERIMENTEL: Arm II (brachyterapi, paclitaxel, carboplatin)
Patienter gennemgår vaginal manchet brachyterapi omfattende 3-5 højdosis brachyterapibehandlinger over ca. 2 uger eller 1 eller 2 lavdosis brachyterapibehandlinger over 1-2 dage. Begyndende inden for 3 uger efter påbegyndelse af brachyterapi, får patienterne paclitaxel IV over 3 timer og carboplatin IV over 30-60 minutter på dag 1. Kemoterapi gentages hver 21. dag i op til 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Andet: Spørgeskemaadministration
Hjælpestudier
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Stråling: Intern Stråleterapi
Gennemgå vaginal manchet brachyterapi
Andre navne:
  • Intern strålings brachyterapi
  • Strålingsbrachyterapi
  • BRACHYTERAPI
  • indre stråling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Antal deltagere med tilbagevendende eller dødsbegivenheder ved primær analyse
Tidsramme: Inden for 4 uger efter afslutning eller ophør af studiebehandling, derefter hver 6. måned i 2 år, derefter årligt i 3 år, derefter som klinisk indiceret, vurderet op til 10 år
Gentagelsesfri overlevelse er perioden fra studiestart til sygdomsgentagelse, død eller dato for sidste kontakt
Inden for 4 uger efter afslutning eller ophør af studiebehandling, derefter hver 6. måned i 2 år, derefter årligt i 3 år, derefter som klinisk indiceret, vurderet op til 10 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Antal deltagere med dødsbegivenheder
Tidsramme: Samlet overlevelse måles fra studieoptagelse i op til 10 år.
Antallet af dødsfald er rapporteret. Samlet overlevelse er rapporteret af antallet af dødsfald, der forekommer under undersøgelsen.
Samlet overlevelse måles fra studieoptagelse i op til 10 år.
Antal deltagere med gentagelsessteder
Tidsramme: Inden for 4 uger efter afslutning eller ophør af undersøgelsesbehandling, derefter hver 6. måned i 2 år, derefter årligt i 3 år, derefter som klinisk indiceret derefter, op til 10 år
Tre konkurrerende risikoanalyser blev udført for tre forskellige typer af tilbagefald: 1) enhver vaginal, 2) enhver bækken- eller PA-knude og 3) enhver fjerntliggende. Mere end én type recidiv kan tælles for en individuel patient. Et dødsfald forud for en bestemt type gentagelse blev betragtet som en konkurrerende begivenhed.
Inden for 4 uger efter afslutning eller ophør af undersøgelsesbehandling, derefter hver 6. måned i 2 år, derefter årligt i 3 år, derefter som klinisk indiceret derefter, op til 10 år
Patient rapporteret træthed
Tidsramme: Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling
Patienten rapporterede træthed som målt med skalaen Funktionel vurdering af kronisk sygdomsterapi-træthed (FACIT-træthed). FACIT-Fatigue indeholder 13 genstande. Hvert element blev scoret ved hjælp af en 5-punkts skala (0=slet ikke; 1=en lille smule; 2=noget; 3=en smule; 4=meget). For de negative poster blev tilbageførsel udført før scoreberegning. Ifølge FACIT-målesystemet var Fatigue-scoren summeringen af ​​de enkelte emnescores, hvis mere end 50 % af subskalapunkterne blev besvaret. Når der fandtes ubesvarede emner, blev en underskala-score forholdsmæssigt fordelt ved at gange gennemsnittet af de besvarede emnescores med antallet af emner i skalaen. FACIT-træthedsscoren varierer fra 0-52 med en høj score tyder på mindre træthed.
Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling
Patientrapporteret neurotoksicitet
Tidsramme: Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling.
Patient rapporterede neurotoksicitetssymptomer målt med funktionel vurdering af cancerterapi/gynækologisk onkologigruppe - neurotoksicitetsunderskala (kort version) (FACT/GOG-Ntx underskala). FACT/GOG-Ntx underskalaen indeholder 4 punkter. Hvert element blev scoret ved hjælp af en 5-punkts skala (0=slet ikke; 1=en lille smule; 2=noget; 3=en smule; 4=meget). For de negative poster blev tilbageførsel udført før scoreberegning. Ifølge FACIT-målesystemet var Ntx-scoren summeringen af ​​de enkelte emnescores, hvis mere end 50 % af underskalapunkterne blev besvaret. Når der fandtes ubesvarede emner, blev en underskala-score forholdsmæssigt fordelt ved at gange gennemsnittet af de besvarede emnescores med antallet af emner i skalaen. Ntx-scoren spænder fra 0-16 med en høj score, der tyder på mindre neurotoksicitet.
Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling.
Patientrapporteret livskvalitet
Tidsramme: Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling
Patient rapporterede om livskvalitet målt med Treatment Outcome Index of the Functional Assessment of Cancer Therapy for endometriecancer (FACT-En TOI). FACT-En TOI er en skala til vurdering af generel QOL for endometriecancerpatienter. Den består af tre underskalaer: Fysisk velvære (7 punkter), Funktionel velvære (7 punkter) og Endometriumcancer-underskalaen (16 punkter). Hvert punkt i FACT-En TOI blev scoret ved hjælp af en 5-punkts skala (0=slet ikke; 1=en lille smule; 2=noget; 3=en smule; 4=meget). . FACT-En TOI-scoren beregnes som summen af ​​underskala-scorerne, hvis mere end 80 % af FACT-En TOI-punkterne giver gyldige svar, og alle komponentunderskalaerne har gyldige scores. FACT-En TOI-score spænder fra 0-120 med en høj score, der tyder på bedre QOL
Før studiebehandlingen (baseline), 4 uger efter start af studiebehandling, 10-11 uger efter start af studiebehandling, 8 måneder efter start af studiebehandling, 14 måneder efter start af studiebehandling

Andre resultatmål

Resultatmål
Tidsramme
Genekspressionsbaseret risikoscore
Tidsramme: Baseline
Baseline

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Gynecologic Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Marcus E Randall, NRG Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (FAKTISKE)

23. marts 2009

Primær færdiggørelse (FAKTISKE)

29. december 2014

Datoer for studieregistrering

Først indsendt

11. december 2008

Først indsendt, der opfyldte QC-kriterier

11. december 2008

Først opslået (SKØN)

12. december 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

20. marts 2019

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

8. marts 2019

Sidst verificeret

1. marts 2019

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • GOG-0249 (ANDET: CTEP)
  • U10CA180868 (U.S. NIH-bevilling/kontrakt)
  • U10CA027469 (U.S. NIH-bevilling/kontrakt)
  • NCI-2009-00610 (REGISTRERING: CTRP (Clinical Trial Reporting Program))
  • CDR0000629591

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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