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Zoledronsyre til behandling af patienter med metastatisk brystkræft, metastatisk prostatakræft eller myelomatose med knogleinvolvering

8. oktober 2018 opdateret af: Alliance for Clinical Trials in Oncology

Et randomiseret, fase III-studie af standarddosering versus længere doseringsinterval af zoledronsyre ved metastatisk kræft

Dette randomiserede fase III-forsøg studerer to forskellige skemaer af zoledronsyre for at sammenligne, hvor godt de virker til at reducere knoglerelaterede komplikationer hos patienter med brystkræft, prostatacancer eller myelomatose, der har spredt sig til andre steder i kroppen og har knogleinvolvering. Knoglerelaterede komplikationer er en væsentlig årsag til morbiditet hos patienter med metastatisk prostatacancer, brystkræft og myelomatose. Zoledronsyre kan stoppe væksten af kræftceller i knoglen og kan hjælpe med at lindre nogle af symptomerne forårsaget af knoglemetastaser. Det vides endnu ikke, om det er mere effektivt at give zoledronsyre mere eller mindre hyppigt til behandling af patienter med metastatisk cancer, der har spredt sig til knoglen.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Medicin: zoledronsyre

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At bestemme, om behandling med zoledronsyre hver 12. uge ikke er ringere end behandling hver 4. uge til patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelomatose, der involverer knogler, målt ved andelen, der oplever mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.

SEKUNDÆRE MÅL:

I. At sammenligne smertescore (Brief Pain Inventory) af patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering.

II. At sammenligne den funktionelle status (Eastern Cooperative Oncology Group [ECOG] præstationsstatus) for patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der modtager hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering.

III. At sammenligne forekomsten af osteonekrose i kæben hos patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering.

IV. At sammenligne forekomsten af nyreinsufficiens hos patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får dosering hver 4. uge.

V. At sammenligne skeletmorbiditetsraten for disse patienter, defineret som antallet af skeletrelaterede hændelser pr. år, for patienter, der får hver 12. uges dosering med dem, der får hver 4. uges dosering.

VI. At sammenligne undertrykkelsen af serummarkører for knogleresorption hos patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering.

VII. For at bestemme, om hver 12. uges behandling med zoledronsyre ikke er ringere end hver 4. uges behandling for hver undergruppe af patienter med enten brystkræft, prostatacancer eller myelomatose, målt ved andelen, der oplever mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM I: Patienter får zoledronsyre intravenøst (IV) over mindst 15 minutter hver 4. uge i op til 2 år i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienter får zoledronsyre IV over mindst 15 minutter hver 12. uge i op til 2 år i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 4. uge i 2 år fra registrering.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1822

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alaska
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
- Arizona
  - Scottsdale, Arizona, Forenede Stater, 85259-5499
    - Mayo Clinic Scottsdale
- California
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants - Castro Valley
  - Fairfield, California, Forenede Stater, 94533
    - North Bay Cancer Center
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology
  - La Jolla, California, Forenede Stater, 92093-0658
    - Rebecca and John Moores UCSD Cancer Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forenede Stater, 94040
    - El Camino Hospital Cancer Center
  - Mountain View, California, Forenede Stater, 94040
    - Camino Medical Group - Treatment Center
  - Northridge, California, Forenede Stater, 91328
    - Leavey Cancer Center at Northridge Hospital Medical Center
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94602
    - Highland General Hospital
  - Oakland, California, Forenede Stater, 94609
    - Larry G Strieff MD Medical Corporation
  - Oakland, California, Forenede Stater, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Breast Surgeons, Incorporated
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee, Incorporated
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation
  - Paradise, California, Forenede Stater, 95969
    - Feather River Hospital Cancer Center
  - Pismo Beach, California, Forenede Stater, 93449
  - San Diego, California, Forenede Stater, 92161
    - Veterans Affairs Medical Center - San Diego
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center - San Diego
  - San Pablo, California, Forenede Stater, 94806
    - Doctors Medical Center - San Pablo Campus
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Cancer Center - Colorado Springs
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - St. Anthony Central Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Front Range Cancer Specialists
  - Grand Junction, Colorado, Forenede Stater, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Hope Cancer Care Center at Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary - Corwin Regional Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Hartford, Connecticut, Forenede Stater, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Manchester, Connecticut, Forenede Stater, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital Cancer Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Tunnell Cancer Center at Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20002
    - Kaiser Permanente at Capitol Hill Medical Center
- Florida
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward General Medical Center Cancer Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Jacksonville, Florida, Forenede Stater, 32224
    - Mayo Clinic - Jacksonville
  - Jupiter, Florida, Forenede Stater, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lake Worth, Florida, Forenede Stater, 33461
    - Cancer Center of South Florida Foundation, Incorporated
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803-1273
    - Florida Hospital Cancer Institute at Florida Hospital Orlando
  - Weston, Florida, Forenede Stater, 33331
    - Cleveland Clinic Florida - Weston
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  - Atlanta, Georgia, Forenede Stater, 30322
    - Winship Cancer Institute of Emory University
  - Decatur, Georgia, Forenede Stater, 30033
    - Veterans Affairs Medical Center - Atlanta (Decatur)
  - Savannah, Georgia, Forenede Stater, 31403-3089
    - Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Idaho
  - Boise, Idaho, Forenede Stater, 83712
    - Mountain States Tumor Institute at St. Luke's Regional Medical Center
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
  - Lewiston, Idaho, Forenede Stater, 83501
    - St. Joseph Regional Medical Center
- Illinois
  - Chicago, Illinois, Forenede Stater, 60640
    - Louis A. Weiss Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60612-7243
    - University of Illinois Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612-3785
    - John H. Stroger, Jr. Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60612
    - Veterans Affairs Medical Center - Chicago Westside Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Evanston, Illinois, Forenede Stater, 60201-1781
    - Evanston Hospital
  - Freeport, Illinois, Forenede Stater, 61032
    - Leonard C. Ferguson Cancer Center
  - Hines, Illinois, Forenede Stater, 60141
    - Veterans Affairs Medical Center - Hines
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates, Limited - West
  - La Grange, Illinois, Forenede Stater, 60525
    - La Grange Memorial Hospital
  - Moline, Illinois, Forenede Stater, 61265
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants - Naperville
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Center for Cancer Care
  - Springfield, Illinois, Forenede Stater, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic, LLC
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology-Oncology, PC - Elkhart
  - Kokomo, Indiana, Forenede Stater, 46904
    - Howard Community Hospital
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, Forenede Stater, 47904
    - Clarian Arnett Cancer Care
  - Merrillville, Indiana, Forenede Stater, 46410
    - Suniti Medical Corporation
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Michiana Hematology-Oncology, PC - South Bend
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Saint Joseph Regional Medical Center
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC - Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital & Health Care Services
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC - La Porte
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, PC
  - Bettendorf, Iowa, Forenede Stater, 52722
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Regional Cancer Center at Mercy Medical Center
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Iowa Blood and Cancer Care
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates - West Des Moines
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Iowa City, Iowa, Forenede Stater, 52242-1002
    - Holden Comprehensive Cancer Center at University of Iowa
  - Iowa City, Iowa, Forenede Stater, 52246
    - Veterans Affairs Medical Center - Iowa City
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forenede Stater, 52501
    - McCreery Cancer Center at Ottumwa Regional
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates, LLP
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center - Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Cancer Treatment Center
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas, PA - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas, PA - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, PA - El Dorado
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas, PA - Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67901
    - Cancer Center of Kansas, PA - Liberal
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas, PA - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's Hospital - South
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas, PA - Parsons
  - Prairie Village, Kansas, Forenede Stater, 66208
    - CCOP - Kansas City
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas, PA - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas, PA - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton-O'Neil Cancer Center
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas, PA - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas, PA - Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas, PA - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates in Womens Health, PA - North Review
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas, PA - Winfield
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center - Bluebonnet
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Health Center - Covington
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Medical Center of Louisiana - New Orleans
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - CancerCare of Maine at Eastern Maine Medical Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21218
    - Union Memorial Hospital
  - Baltimore, Maryland, Forenede Stater, 21237
    - Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
  - Baltimore, Maryland, Forenede Stater, 21239
    - Good Samaritan Hospital of Maryland
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente at Woodlawn Medical Center
  - Easton, Maryland, Forenede Stater, 21601
    - Shore Regional Cancer Center at Memorial Hospital - Easton
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital of Cecil County
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente - Gaithersburg Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
  - Towson, Maryland, Forenede Stater, 21204
    - Cancer Institute at St. Joseph Medical Center
- Massachusetts
  - Attleboro, Massachusetts, Forenede Stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center Cancer Center
  - Brighton, Massachusetts, Forenede Stater, 02135-2997
    - Caritas St. Elizabeth's Medical Center
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Caritas Holy Family Hospital
  - Plymouth, Massachusetts, Forenede Stater, 02360
    - Jordan Hospital Club Cancer Center
  - Quincy, Massachusetts, Forenede Stater, 02169
    - Commonwealth Hematology-Oncology, PC - Quincy
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Dearborn, Michigan, Forenede Stater, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Escanaba, Michigan, Forenede Stater, 49431
    - Green Bay Oncology, Limited - Escanaba
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Blanc, Michigan, Forenede Stater, 48439
    - Genesys Regional Medical Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Dickinson County Healthcare System
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Memorial Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - West Michigan Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912-1811
    - Sparrow Regional Cancer Center
  - Livonia, Michigan, Forenede Stater, 48154
    - St. Mary Mercy Hospital
  - Marquette, Michigan, Forenede Stater, 49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital - Monroe
  - Niles, Michigan, Forenede Stater, 49120
    - Michiana Hematology Oncology PC - Niles
  - Pontiac, Michigan, Forenede Stater, 48341-2985
    - St. Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Mercy Regional Cancer Center at Mercy Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute at Saint Mary's - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeside Cancer Specialists, PLLC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Regional Cancer Care Center - St. Joseph
  - Warren, Michigan, Forenede Stater, 48093
    - St. John Macomb Hospital
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Bemidji
  - Brainerd, Minnesota, Forenede Stater, 56401
    - St. Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805-1983
    - Duluth Clinic Cancer Center - Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller - Dwan Medical Center
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Mankato, Minnesota, Forenede Stater, 56002
    - Immanuel St. Joseph's
  - Maplewood, Minnesota, Forenede Stater, 55109
    - HealthEast Cancer Care at St. John's Hospital
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology - Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center - Minneapolis
  - Robbinsdale, Minnesota, Forenede Stater, 55422-2900
    - Humphrey Cancer Center at North Memorial Outpatient Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic Cancer Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Cancer Center
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital Cancer Care Center
  - Shakopee, Minnesota, Forenede Stater, 55379
    - St. Francis Cancer Center at St. Francis Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Willmar Cancer Center at Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology - Woodbury
- Mississippi
  - Gulfport, Mississippi, Forenede Stater, 39502
    - Memorial Hospital at Gulfport
  - Jackson, Mississippi, Forenede Stater, 39216
    - Veterans Affairs Medical Center - Jackson
  - Keesler Air Force Base, Mississippi, Forenede Stater, 39534
    - Keesler Air Force Base Medical Center
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center at Carrie J. Babb Cancer Center
  - Branson, Missouri, Forenede Stater, 65616
    - Skaggs Cancer Center at Skaggs Regional Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Goldschmidt Cancer Center
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Cancer Institute at Saint Luke's Hospital
  - Kansas City, Missouri, Forenede Stater, 64116
    - Parvin Radiation Oncology
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology Oncology Associates, Incorporated
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Rolla, Missouri, Forenede Stater, 65401
    - Phelps County Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology, Incorporated
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Comprehensive Cancer Care, PC
  - Springfield, Missouri, Forenede Stater, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, Forenede Stater, 59101
    - St. Vincent Healthcare Cancer Care Services
  - Billings, Montana, Forenede Stater, 59107-7000
    - Billings Clinic - Downtown
  - Billings, Montana, Forenede Stater, 59102
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Cancer Center
  - Butte, Montana, Forenede Stater, 59701
    - St. James Healthcare Cancer Care
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic - Main Facility
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Cancer Institute at Benefis Healthcare
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology at KRMC
  - Missoula, Montana, Forenede Stater, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, Forenede Stater, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
  - Kearney, Nebraska, Forenede Stater, 68848-1990
    - Good Samaritan Cancer Center at Good Samaritan Hospital
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Cancer Resource Center - Lincoln
  - North Platte, Nebraska, Forenede Stater, 69103
    - Callahan Cancer Center at Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68198-6805
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegant Health Cancer Center at Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Lakeside Hospital
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Nevada Cancer Research Foundation
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Institute for Cancer at Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates - Reno
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
  - Dover, New Hampshire, Forenede Stater, 03820
    - Seacoast Cancer Center at Wentworth - Douglass Hospital
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Center for Cancer Care at Exeter Hospital
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology - Hematology, PA - Hooksett
  - Laconia, New Hampshire, Forenede Stater, 03246
    - Lakes Region General Hospital
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Foundation Medical Partners
- New Jersey
  - Elizabeth, New Jersey, Forenede Stater, 07207
    - Trinitas Comprehensive Cancer Center at Trinitas Hospital
  - Marlton, New Jersey, Forenede Stater, 08053
    - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
  - Neptune, New Jersey, Forenede Stater, 07753
    - Jersey Shore Cancer Center at Jersey Shore University Medical Center
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87131-5636
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Hematology Oncology Associates, PC
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center - Downtown
- New York
  - Bronx, New York, Forenede Stater, 10451
    - Lincoln Medical and Mental Health Center
  - Brooklyn, New York, Forenede Stater, 11203
    - SUNY downstate Medical Center
  - Brooklyn, New York, Forenede Stater, 11203
    - Kings County Hospital Center
  - Buffalo, New York, Forenede Stater, 14263-0001
    - Roswell Park Cancer Institute
  - Cooperstown, New York, Forenede Stater, 13326
    - Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
  - Elmhurst, New York, Forenede Stater, 11373
    - Elmhurst Hospital Center
  - Glens Falls, New York, Forenede Stater, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - Jamaica, New York, Forenede Stater, 11432
    - Queens Cancer Center of Queens Hospital
  - Lake Success, New York, Forenede Stater, 11042
    - Monter Cancer Center of the North Shore-LIJ Health System
  - Manhasset, New York, Forenede Stater, 11030
    - CCOP - North Shore University Hospital
  - Manhasset, New York, Forenede Stater, 11030
    - Don Monti Comprehensive Cancer Center at North Shore University Hospital
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forenede Stater, 10021
    - New York Weill Cornell Cancer Center at Cornell University
  - New York, New York, Forenede Stater, 10016
    - NYU Cancer Institute at New York University Medical Center
  - Staten Island, New York, Forenede Stater, 10305
    - Nalitt Cancer Institute at Staten Island University Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - Veterans Affairs Medical Center - Syracuse
  - White Plains, New York, Forenede Stater, 10601
    - Dickstein Cancer Treatment Center at White Plains Hospital Center
- North Carolina
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greenville, North Carolina, Forenede Stater, 27834
    - Leo W. Jenkins Cancer Center at ECU Medical School
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Pardee Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Kinston Medical Specialists
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Zimmer Cancer Center at New Hanover Regional Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27157-1096
    - Wake Forest University Comprehensive Cancer Center
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Medcenter One Hospital Cancer Care Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic, PC
  - Bismarck, North Dakota, Forenede Stater, 58502
    - St. Alexius Medical Center Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58102
    - MeritCare Broadway
  - Fargo, North Dakota, Forenede Stater, 58122
    - Roger Maris Cancer Center at MeritCare Hospital
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center at Altru Hospital
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancercare Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Wood County Oncology Center
  - Canton, Ohio, Forenede Stater, 44710-1799
    - Aultman Cancer Center at Aultman Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Cancer Care Center at MetroHealth Medical Center
  - Columbus, Ohio, Forenede Stater, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health - West Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center Cancer Care
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Columbus, Ohio, Forenede Stater, 43210-1240
    - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45420
    - CCOP - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Community Cancer Center
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Medical Associates
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537-1839
    - Northwest Ohio Oncology Center
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic - Oregon
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center Cancer Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital Cancer Center
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43606
    - Toledo Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - Medical University of Ohio Cancer Center
  - Toledo, Ohio, Forenede Stater, 43617
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic, Incorporated - Main Clinic
  - Toledo, Ohio, Forenede Stater, 43623
    - St. Anne Mercy Hospital
  - Troy, Ohio, Forenede Stater, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Mount Carmel St. Ann's Cancer Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - United States Air Force Medical Center - Wright-Patterson
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - LaFortune Cancer Center at St. John Medical Center
- Oregon
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Grants Pass, Oregon, Forenede Stater, 97527
    - Three Rivers Community Hospital
  - Medford, Oregon, Forenede Stater, 97504
    - Dubs Cancer Center at Rogue Valley Medical Center
  - Medford, Oregon, Forenede Stater, 97504
    - Providence Cancer Center at PMCC
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Willamette Falls Hospital
  - Portland, Oregon, Forenede Stater, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Health Care - Portland
  - Salem, Oregon, Forenede Stater, 97309-5014
    - Salem Hospital Regional Cancer Care Services
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822-0001
    - Geisinger Cancer Institute at Geisinger Health
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - Doylestown Hospital Cancer Center
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Regional Cancer Center at Delaware County Memorial Hospital
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Dale and Frances Hughes Cancer Center at Pocono Medical Center
  - Easton, Pennsylvania, Forenede Stater, 18042
    - Easton Regional Cancer Center at Easton Hospital
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Hazleton Cancer Center
  - Lancaster, Pennsylvania, Forenede Stater, 17604
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - St. Mary Regional Cancer Center
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital Cancer Center
  - Paoli, Pennsylvania, Forenede Stater, 19301-1792
    - Cancer Center of Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Joan Karnell Cancer Center at Pennsylvania Hospital
  - Phoenixville, Pennsylvania, Forenede Stater, 19460
    - Cancer Center at Phoenixville Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15240
    - Veterans Affairs Medical Center - Pittsburgh
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Hematology and Oncology Associates of Northeastern Pennsylvania
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group - Scenery Park
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forenede Stater, 19390-9499
    - Jennersville Regional Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Cancer Center at Lankenau Hospital
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - CCOP - Main Line Health
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02906
    - Miriam Hospital
  - Providence, Rhode Island, Forenede Stater, 02908
    - Roger Williams Medical Center
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital Comprehensive Cancer Center
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Cancer Center
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper St. Francis Cancer Center at Roper Hospital
  - Florence, South Carolina, Forenede Stater, 29501
    - McLeod Regional Medical Center
  - Lancaster, South Carolina, Forenede Stater, 29720
    - Carolina Blood and Cancer Care Associates, PA
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Carolina Blood and Cancer Care
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - CCOP - Upstate Carolina
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
  - West Columbia, South Carolina, Forenede Stater, 29169
    - Lexington Medical Center
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center, PC
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5039
    - Sanford Cancer Center at Sanford USD Medical Center
- Tennessee
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22901
    - Martha Jefferson Hospital Cancer Care Center
  - Fairfax, Virginia, Forenede Stater, 22031
    - Medical Oncology and Hematology Associates of North Virginia - Fairfax
  - Fairfax, Virginia, Forenede Stater, 22033
    - Kaiser Permanente Medical Center - Fair Oaks
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology, Incorporated
  - Richmond, Virginia, Forenede Stater, 23249
    - Veterans Affairs Medical Center - Richmond
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - Virginia Commonwealth University Massey Cancer Center
- Washington
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Cancer Center at Overlake Hospital Medical Center
  - Centralia, Washington, Forenede Stater, 98531-9027
    - Providence Centralia Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - St. Francis Hospital
  - Kirkland, Washington, Forenede Stater, 98033
    - Cascade Cancer Center at Evergreen Hospital Medical Center
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence St. Peter Hospital Regional Cancer Center
  - Puyallup, Washington, Forenede Stater, 98372
    - Good Samaritan Cancer Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Medical Center
  - Tacoma, Washington, Forenede Stater, 98405-3004
    - Franciscan Cancer Center at St. Joseph Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - CCOP - Northwest
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Regional Cancer Center at Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98499
    - St. Clare Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - Southwest Washington Medical Center Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Huntington, West Virginia, Forenede Stater, 25702
    - St. Mary's Regional Cancer Center at St. Mary's Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Memorial Hospital
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic - Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Care at Regional Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54703-1510
    - Midelfort Clinic - Luther
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - Janesville, Wisconsin, Forenede Stater, 53547
    - Mercy Regional Cancer Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Center for Cancer and Blood
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Franciscan Skemp Healthcare - La Crosse Campus
  - Manitowoc, Wisconsin, Forenede Stater, 54221-1450
    - Holy Family Memorial Medical Center Cancer Care Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic - Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Columbia Saint Mary's Hospital - Ozaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Columbia-Saint Mary's Cancer Care Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic - Lakeland Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - D.N. Greenwald Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - Regional Cancer Center at Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology, Limited - Oconto Falls
  - Racine, Wisconsin, Forenede Stater, 53405
    - All Saints Cancer Center at Wheaton Franciscan Healthcare
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ministry Medical Group at Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic - Indianhead Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - St. Nicholas Hospital
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Marshfield Clinic at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology, Limited - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - University of Wisconcin Cancer Center at Aspirus Wausau Hospital
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Oncology Alliance, SC - Milwaukee - West
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Riverview UW Cancer Center at Riverview Hospital
- Wyoming
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Kvalifikationskriterier:

Histologisk dokumentation for en af følgende: brystadenokarcinom, prostataadenokarcinom eller myelomatose
Mindst ét sted for knoglemetastase eller knogleinvolvering ved røntgenbillede, herunder almindelig røntgen, computertomografi (CT), positronemissionstomografi (PET)-scanning, PET/CT-scanning, magnetisk resonansbilleddannelse, knogleskanning eller skeletundersøgelse; ubestemte læsioner bør bekræftes med en anden billeddiagnostisk metode
Ingen forudgående behandling med IV bisfosfonater er tilladt; forudgående behandling med orale bisfosfonater er tilladt, men de skal seponeres før påbegyndelse af protokolbehandling
Ingen tidligere behandling med denosumab
Ingen forudgående behandling med radiofarmaka; forudgående behandling med radioaktivt jod er tilladt; prostatakræftpatienter behandlet med brachyterapi er berettigede
Forudgående strålebehandling af knogler er tilladt, forudsat at mindst ét sted med knoglemetastase ikke er blevet bestrålet, og strålingen er afsluttet før registrering; der bør ikke være nogen plan for strålebehandling til ikke-bestrålede steder med knoglemetastaser
Forudgående adjuverende og metastatisk kemoterapi, biologisk terapi og endokrin terapi er tilladt
Ingen aktuel behandling med forsøgsmiddel(er)
Patienter med kendte hjernemetastaser er ikke kvalificerede; patienter, der udvikler hjernemetastaser under undersøgelsen, vil få lov til at fortsætte behandlingen som tildelt
Ikke gravid og ikke ammende
ECOG ydeevne status 0-2
Beregnet kreatininclearance >= 30 ml/min
Korrigeret serumcalcium >= 8,0 mg/dL (2,00 mmol/L) og < 11,6 mg/dL (2,90 mmol/L) * Korrigeret serumcalcium skal beregnes ved brug af standard institutionel praksis

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Støttende pleje
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm I (zoledronsyre hver 4. uge) Patienter får zoledronsyre IV over mindst 15 minutter hver 4. uge i op til 2 år i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: zoledronsyre Givet IV
Eksperimentel: Arm II (zoledronsyre hver 12. uge) Patienter får zoledronsyre IV over mindst 15 minutter hver 12. uge i op til 2 år i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: zoledronsyre Givet IV

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Procentdel af deltagere med mindst én skeletrelateret hændelse (SRE) inden for 2 år efter randomisering Tidsramme: 2 år	For at afgøre, om behandling med zoledronsyre hver 12. uge ikke er ringere end terapi hver 4. uge for patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelomatose, der involverer knogler, målt ved andelen af patienter, der ville have oplevet mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.	2 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Gennemsnitlig smerteintensitetsscore vurderet af spørgeskemaet Brief Pain Inventory (BPI) Tidsramme: fra baseline op til 2 år	At sammenligne smertescore (Brief Pain Inventory) af patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får dosering hver 4. uge. Ændringsscorerne blev evalueret i en generel lineær model med gentagne mål for behandlingseffekt og tidstendensen med patientspecifikke karakteristika, der blev justeret for den gennemsnitlige interferensscore. Specifikt er forskellen i scoreændring pr. 4 uger for arm I, der bruger arm II som reference. BPI-spørgeskemaets score går fra 0 er ingen smerte til 10 er mest smerte. Den gennemsnitlige score er rapporteret for hver arm nedenfor.	fra baseline op til 2 år
Gennemsnitlig ECOG-ydelsesstatus Tidsramme: fra baseline op til 2 år	At sammenligne funktionel status (ECOG-præstationsstatus) for patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der modtager hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Ændringsscorerne blev evalueret i en generel lineær model med gentagne mål for behandlingseffekt og tidstendensen med patientspecifikke karakteristika, der blev justeret. Specifikt er forskellen i scoreændring pr. 4 uger for arm I, der bruger arm II som reference. ECOG præstationsstatus er en måling af en patientens funktionsnedsættelse, der spænder fra 0, fuldt aktiv og i stand til at udføre al præstation før sygdommen uden begrænsninger, til 5, døde. Den gennemsnitlige præstationsstatus rapporteres nedenfor efter arm.	fra baseline op til 2 år
Forekomst af osteonekrose i kæben Tidsramme: fra baseline op til 2 år	At sammenligne forekomsten af osteonekrose i kæben hos patienter med metastatisk brystkræft, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Procentdelen af deltagere med osteonekrose er rapporteret her.	fra baseline op til 2 år
Forekomst af nyreinsufficiens Tidsramme: fra baseline op til 2 år	At sammenligne forekomsten af nyreinsufficiens hos patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der modtager hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Procentdelen af patienter med nedsat nyrefunktion, defineret som grad 3 eller grad 4 øget kreatinin (Common Terminology Criteria for Adverse Events version 3.0), vil blive rapporteret her.	fra baseline op til 2 år
Skeletmorbiditetsrate Tidsramme: fra baseline op til 2 år	For at sammenligne skeletmorbiditetsraten, defineret som antallet af skeletrelaterede hændelser pr. år, for patienter, der får hver 12. uges dosering med dem, der får hver 4. uges dosering.	fra baseline op til 2 år
Knogleomsætning vurderet ved serum C-telopeptid (CTX) niveauer (brystkræft) Tidsramme: fra baseline op til 2 år	At sammenligne undertrykkelsen af serummarkører for knogleresorption hos patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Antallet af patienter med høje og lave CTX-værdier efter arm vil blive rapporteret her.	fra baseline op til 2 år
Andel af patienter, der har mindst én SRE inden for 24 måneder efter randomisering for undergrupperne af patienter med brystkræft Tidsramme: fra baseline op til 24 måneder	At bestemme, om hver 12. uges behandling med zoledronsyre ikke er ringere end hver 4. uges behandling for patienter med brystkræft, målt ved andelen, der oplever mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.	fra baseline op til 24 måneder
Andel af patienter, der har mindst én SRE inden for 24 måneder efter randomisering for undergrupperne af patienter med prostatakræft Tidsramme: fra baseline op til 24 måneder	At bestemme, om hver 12. uges behandling med zoledronsyre ikke er ringere end hver 4. uges behandling for patienter med prostatacancer, målt ved andelen, der oplever mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.	fra baseline op til 24 måneder
Andel af patienter, der har mindst én SRE inden for 24 måneder efter randomisering for undergrupperne af patienter med myelomatose Tidsramme: fra baseline op til 24 måneder	For at bestemme, om hver 12. uges behandling med zoledronsyre ikke er ringere end hver 4. uges behandling for patienter med myelomatose, målt ved andelen, der oplever mindst én skeletrelateret hændelse inden for 24 måneder efter randomisering.	fra baseline op til 24 måneder
Knogleomsætning vurderet ved serum C-telopeptid (CTX) niveauer (prostatakræft) Tidsramme: fra baseline op til 24 måneder	At sammenligne undertrykkelsen af serummarkører for knogleresorption hos patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Antallet af patienter med høje og lave CTX-værdier efter arm vil blive rapporteret her.	fra baseline op til 24 måneder
Knogleomsætning vurderet ved serum C-telopeptid (CTX) niveauer (multipelt myelom) Tidsramme: fra baseline op til 24 måneder	At sammenligne undertrykkelsen af serummarkører for knogleresorption hos patienter med metastatisk brystcancer, metastatisk prostatacancer eller myelom, der involverer knogle, der får hver 12. uges dosering af zoledronsyre, med dem, der får hver 4. uges dosering. Antallet af patienter med høje og lave CTX-værdier efter arm vil blive rapporteret her.	fra baseline op til 24 måneder

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Studiestol: Andrew L. Himelstein, MD, Helen F. Graham Cancer Center at Christiana Hospital

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Himelstein AL, Foster JC, Khatcheressian JL, Roberts JD, Seisler DK, Novotny PJ, Qin R, Go RS, Grubbs SS, O'Connor T, Velasco MR Jr, Weckstein D, O'Mara A, Loprinzi CL, Shapiro CL. Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA. 2017 Jan 3;317(1):48-58. doi: 10.1001/jama.2016.19425.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. marts 2009

Primær færdiggørelse (Faktiske)

1. juni 2014

Studieafslutning (Faktiske)

1. januar 2017

Datoer for studieregistrering

Først indsendt

24. marts 2009

Først indsendt, der opfyldte QC-kriterier

24. marts 2009

Først opslået (Skøn)

25. marts 2009

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

7. november 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

8. oktober 2018

Sidst verificeret

1. oktober 2018

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

CALGB-70604
U10CA037447 (U.S. NIH-bevilling/kontrakt)
CDR0000637947 (Registry Identifier: NCI Physician Data Query)
NCI-2009-01102 (Registry Identifier: NCI Clinical Trial Reporting Program)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Smerte

Quiropraxia y Equilibrio
Universidad Nacional Andres Bello

Afsluttet

Perkutan mikroelektrolyse på myofasciale triggerpunkterssmerter. (MEP)

Myofascial Trigger Point Pain (MTrP)

Chile
East Carolina University

Trukket tilbage

Fænotyping af akut smerte til opdagelsesforskning og rettet terapi

Post op Pain

Forenede Stater
Quiropraxia y Equilibrio

Ikke rekrutterer endnu

High Intensity Laser Therapy (HILT) på myofasciale triggerpunkter. (HILT)

Myofascial Trigger Point Pain (MTrP)

Chile
Wake Forest University Health Sciences

Rekruttering

Immersive Healing: Virtual Realitys terapeutiske potentiale

Phantom Limb Pain (PLP)

Forenede Stater
Rijnstate Hospital
Saluda Medical Pty Ltd

Tilmelding efter invitation

Vurdering af effektivitet og stimuleringsdækning af Closed-loop Spinal Cord Stimulation (CL-SCS) terapi hos patienter med cervikal elektrodeplacering

Polyneuropatier | Kronisk smertesyndrom | Multi Focal Pain | Mislykket nakkekirurgi syndrom

Holland
University of California, San Diego
Johns Hopkins University; United States Department of Defense; The Cleveland... og andre samarbejdspartnere

Tilmelding efter invitation

Forbedring af postamputationsfunktion ved at mindske fantomsmerte med perioperative kontinuerlige perifere nerveblokke: en multicenterundersøgelse finansieret af forsvarsministeriet

Kirurgisk amputation af nedre ekstremiteter | Post-amputation Phantom Limb Pain

Forenede Stater
Oslo University Hospital
University of Oslo; Fysiofondet; Oslo Metropolitan University

Rekruttering

HIP-selvledelsesundersøgelsen (HIPS)

Gluteal tendinopati | Trochanterisk bursitis | Lateral hoftesmerter | GTPS - Greater Trochanteric Pain Syndrome

Norge
Brugmann University Hospital

Trukket tilbage

Et forsøg med lidokainplaster til amputationssmerter i underekstremiteterne

Phantom Limb Pain (PLP) | Primær/sekundær arhyperalgesi

Belgien
Pôle Saint Hélier

Rekruttering

Evaluering af forholdet mellem varigheden af udviklingen af det komplekse regionale smertesyndrom type 1 (CRPS 1) og effektiviteten af den kontinuerlige perifere nerveblok (CPNB) forbundet med et intensivt genoptræningsprogram (BLOCALGO)

CRPS (Complex Regional Pain Syndrome) Type I

Frankrig
Guna S.p.a

Afsluttet

Evaluering af effektiviteten af brugen af MD Tissue Collagen Medical Device i den infiltrative behandling af Greater Trochanter Pain Syndrome (GTPS) (MEDANTRO)

Større trochanterisk smertesyndrom | Pertrokantær fraktur | Gluteal tendinitis | GTPS - Greater Trochanteric Pain Syndrome | Senelidelse | Gluteal muskler

Italien

Kliniske forsøg med zoledronsyre

University of Calgary

Rekruttering

Ændring af knoglemikroarkitektur og mekanik ved off-label farmaceutisk intervention efter en akut knæskade (ZAPOA)

Slidgigt i knæet | Forreste korsbåndsskader | Forreste korsbåndsruptur | Forreste korsbåndsrivning

Canada
Institut Cancerologie de l'Ouest

Rekruttering

Multicenter medicinsk-økonomisk undersøgelse, der evaluerer effektiviteten af at tilføje ZOlédronique-syre til STERéotaxique-strålebehandling ved behandling af vertebrale metastaser (ZOSTER)

Vertebral metastase

Frankrig
Nantes University Hospital

Afsluttet

Undersøgelse af effekten af zoledronat på lokalt recidiv efter kirurgisk behandling af kæmpecelletumorer i knogle Zométa (Zometa)

Kæmpecelletumorer i knogle

Frankrig
Affiliated Hospital of Hebei University

Ukendt

En undersøgelse af apatinib plus docetaxel til behandling af avanceret ikke-pladecellet ikke-småcellet lungekræft med knoglemetastaser

Ikke-pladeeplade ikke-småcellet lungekræft

Kina
Ultragenyx Pharmaceutical Inc

Afsluttet

Sikkerhed og farmakokinetik af sialinsyretabeller hos patienter med arvelig inklusionskropsmyopati (HIBM)

Hereditary Inclusion Body Myopati (HIBM)

Forenede Stater
University of Colorado, Denver

Afsluttet

Oral aminosyreernæring for at forbedre glukoseudflugter i PCOS (ORANGE)

Fedme | Polycystisk ovariesyndrom | Hepatisk Steatose

Forenede Stater
National University of Ireland, Galway, Ireland
Stanley Medical Research Institute

Afsluttet

Et profylaktisk forsøg med omega-3 flerumættede fedtsyrer ved bipolar lidelse

Bipolar depression

Irland
University of California, Los Angeles

Afsluttet

Undersøgelse af et aminosyretilskud på glukoseniveauer hos overvægtige forsøgspersoner

Glucoseintolerance | Overvægtige | Præ-diabetes

Forenede Stater
Ultragenyx Pharmaceutical Inc

Afsluttet

Et fase 2-studie til evaluering af dosis og farmakodynamisk effektivitet af sialic acid-extended release (SA-ER) tabletter hos patienter med GNE-myopati eller arvelig inklusionskropsmyopati (GNE Myopathy)

Arvelig Inclusion Body Myopati | GNE myopati

Forenede Stater, Israel
Becton, Dickinson and Company

Aktiv, ikke rekrutterende

Klinisk forsøg til registrering af HPV-nukleinsyregenotypebestemmelsessæt

Livmoderhalskræft

Kina

Zoledronsyre til behandling af patienter med metastatisk brystkræft, metastatisk prostatakræft eller myelomatose med knogleinvolvering

Et randomiseret, fase III-studie af standarddosering versus længere doseringsinterval af zoledronsyre ved metastatisk kræft

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Smerte

Kliniske forsøg med zoledronsyre

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Latvia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer