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Carboplatin og Paclitaxel med eller uden cisplatin og strålebehandling til behandling af patienter med trin I, trin II, trin III eller stadium IVA endometriecancer

28. september 2021 opdateret af: Gynecologic Oncology Group

Et randomiseret fase III-forsøg med cisplatin og tumorvolumen rettet bestråling efterfulgt af carboplatin og paclitaxel vs. carboplatin og paclitaxel til optimalt debulk, avanceret endometriekarcinom

Dette randomiserede fase III-studie undersøger carboplatin og paclitaxel for at se, hvor godt de virker med eller uden cisplatin og strålebehandling ved behandling af patienter med stadium I-IVA endometriecancer. Lægemidler, der bruges i kemoterapi, såsom carboplatin, paclitaxel og cisplatin, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Strålebehandling bruger højenergi røntgenstråler til at dræbe tumorceller. At give kemoterapi og strålebehandling efter operationen kan dræbe eventuelle tumorceller, der er tilbage efter operationen. Det vides endnu ikke, om carboplatin og paclitaxel er mere effektive med eller uden cisplatin og strålebehandling til behandling af patienter med endometriecancer.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. For at bestemme, om behandling med cisplatin og volumenrettet stråling efterfulgt af carboplatin og paclitaxel i 4 cyklusser (eksperimentel arm) reducerer frekvensen af tilbagefald eller død (dvs. øger tilbagefaldsfri overlevelse) sammenlignet med kemoterapi bestående af carboplatin og paclitaxel i 6 cyklusser (kontrolarm) hos patienter med stadium III-IVA endometriecarcinom (< 2 cm resterende sygdom) eller patienter med International Federation of Gynecology and Obstetrics (FIGO) 2009 stadium I eller II serøs (livmoderpapillært serøst karcinom [UPSC]) eller klarcellet endometriekarcinom og positiv cytologi.

SEKUNDÆRE MÅL:

I. For at bestemme om behandling med cisplatin og volumenrettet stråling efterfulgt af carboplatin og paclitaxel i 4 cyklusser (eksperimentel arm) reducerer dødsraten (dvs. øger overlevelsen) sammenlignet med kemoterapi bestående af carboplatin og paclitaxel i 6 cyklusser (kontrol) arm) hos patienter med stadium III-IVA endometriecarcinom (< 2 cm resterende sygdom) eller patienter med FIGO 2009 stadium I eller II serøs (UPSC) eller klarcellet endometriecarcinom og positiv cytologi.

II. At sammenligne regimerne med hensyn til akutte og sene bivirkninger af terapi.

III. At bestemme virkningen af patientrapporteret livskvalitet under og efter behandling i op til 1 år med de to behandlingsregimer.

TERTIÆRE MÅL:

I. At samle formalinfikserede, paraffinindlejrede (FFPE) tumorvævs- og fuldblodsprøver til fremtidig forskning.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM I: Patienter får cisplatin intravenøst (IV) på dag 1 og 29. Patienterne gennemgår også strålebehandling én gang dagligt (QD), 5 dage om ugen, i 5-6 uger. Nogle patienter kan derefter gennemgå brachyterapi over 2-3 uger. Begyndende inden for 8 uger efter afslutning af kemoradioterapi får patienterne paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienterne får paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afslutning af studieterapien følges patienterne op hver 3. måned i 2 år, hver 6. måned i 3 år og derefter årligt.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

813

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Quebec
  - Montreal, Quebec, Canada, H3H 2R9
    - The Research Institute of the McGill University Health Centre (MUHC)
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital
  - Montreal, Quebec, Canada, H3T 1M5
    - Saint Mary's Hospital
  - Montreal, Quebec, Canada, H3A 1A1
    - McGill University Health Centre at Royal Victoria Hospital
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Huntsville, Alabama, Forenede Stater, 35805
    - Tennessee Valley Gynecologic Oncology
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
- Arizona
  - Phoenix, Arizona, Forenede Stater, 85013
    - Saint Joseph's Hospital and Medical Center
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
- California
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Carmichael, California, Forenede Stater, 95608
    - Mercy San Juan Medical Center
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord Campus
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente-Fresno
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Long Beach, California, Forenede Stater, 90806
    - Long Beach Memorial Medical Center-Todd Cancer Institute
  - Los Angeles, California, Forenede Stater, 90095
    - UCLA / Jonsson Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Forenede Stater, 92663
    - Gynecologic Oncology Associates-Newport Beach
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Oakland-Broadway
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Rohnert Park, California, Forenede Stater, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Sacramento, California, Forenede Stater, 95819
    - Mercy General Hospital Radiation Oncology Center
  - San Diego, California, Forenede Stater, 92103
    - University of California San Diego
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Barbara, California, Forenede Stater, 93105
    - Cancer Center of Santa Barbara
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Sylmar, California, Forenede Stater, 91342
    - Olive View-University of California Los Angeles Medical Center
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
- Colorado
  - Aurora, Colorado, Forenede Stater, 80045
    - University Of Colorado Hospital
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, Forenede Stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Norwich, Connecticut, Forenede Stater, 06360
    - William Backus Hospital
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forenede Stater, 19713
    - Christiana Gynecologic Oncology LLC
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32701
    - AdventHealth Altamonte
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Jacksonville, Florida, Forenede Stater, 32204
    - Saint Vincent's Medical Center
  - Jacksonville, Florida, Forenede Stater, 32204
    - Southeast Gynecologic Oncology Associates
  - Kissimmee, Florida, Forenede Stater, 34744
    - AdventHealth Kissimmee
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forenede Stater, 33133
    - Mercy Hospital
  - Miami, Florida, Forenede Stater, 33136
    - Jackson Memorial Hospital-Holtz Children's Hospital
  - Orlando, Florida, Forenede Stater, 32806
    - Orlando Health Cancer Institute
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forenede Stater, 32822
    - AdventHealth East Orlando
  - Panama City, Florida, Forenede Stater, 32401
    - Bay Medical Center
  - Sarasota, Florida, Forenede Stater, 34239
    - Sarasota Memorial Hospital
  - Winter Park, Florida, Forenede Stater, 32792
    - AdventHealth Winter Park
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Dekalb Medical Center
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Piedmont Fayette Hospital
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Macon, Georgia, Forenede Stater, 31201
    - Central Georgia Gynecologic Oncology
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Maui Memorial Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Lewiston, Idaho, Forenede Stater, 83501
    - Saint Joseph Regional Medical Center
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forenede Stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Danville, Illinois, Forenede Stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forenede Stater, 62526
    - Heartland Cancer Research NCORP
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Sudarshan K Sharma MD Limited-Gynecologic Oncology
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Monmouth, Illinois, Forenede Stater, 61462
    - Illinois CancerCare-Monmouth
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Normal, Illinois, Forenede Stater, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Radiation Oncology of Northern Illinois
  - Ottawa, Illinois, Forenede Stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Rockford, Illinois, Forenede Stater, 61114
    - SwedishAmerican Regional Cancer Center/ACT
  - Rockford, Illinois, Forenede Stater, 61104
    - Swedish American Hospital
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Dyer, Indiana, Forenede Stater, 46311
    - Franciscan Saint Margaret Health-Dyer Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forenede Stater, 46805
    - Parkview Hospital Randallia
  - Fort Wayne, Indiana, Forenede Stater, 46804
    - Radiation Oncology Associates PC
  - Hammond, Indiana, Forenede Stater, 46320
    - Franciscan Saint Margaret Health-Hammond Campus
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46260
    - Saint Vincent Hospital and Health Care Center
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forenede Stater, 46350
    - IU Health La Porte Hospital
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC - Ames
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic PC-Boone
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - Saint Luke's Regional Medical Center
  - Spencer, Iowa, Forenede Stater, 51301
    - Abben Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Forenede Stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Wichita, Kansas, Forenede Stater, 67214
    - Wesley Medical Center
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Crestview Hills, Kentucky, Forenede Stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Edgewood, Kentucky, Forenede Stater, 41017
    - Saint Elizabeth Medical Center South
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Louisville, Kentucky, Forenede Stater, 40202
    - Norton Hospital Pavilion and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forenede Stater, 40207
    - Norton Suburban Hospital and Medical Campus
  - Pikeville, Kentucky, Forenede Stater, 41501
    - Pikeville Medical Center
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic PLLC
  - Baton Rouge, Louisiana, Forenede Stater, 70817
    - Woman's Hospital
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Touro Infirmary
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Willis-Knighton Medical and Cancer Center
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Portland, Maine, Forenede Stater, 04102
    - Maine Medical Center-Bramhall Campus
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Medical Center- Scarborough Campus
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Christiana Care - Union Hospital
  - Silver Spring, Maryland, Forenede Stater, 20910
    - Holy Cross Hospital
- Massachusetts
  - Attleboro, Massachusetts, Forenede Stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center - University Campus
  - Worcester, Massachusetts, Forenede Stater, 01605
    - UMass Memorial Medical Center - Memorial Division
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Brownstown, Michigan, Forenede Stater, 48183
    - Henry Ford Cancer Institute-Downriver
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital - Dearborn
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Hospital Niles
  - Novi, Michigan, Forenede Stater, 48377
    - Henry Ford Medical Center-Columbus
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48085
    - William Beaumont Hospital - Troy
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - West Bloomfield, Michigan, Forenede Stater, 48322
    - Henry Ford West Bloomfield Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology Inc
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Springfield, Missouri, Forenede Stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forenede Stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - Missouri Valley Cancer Consortium
- Nevada
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - 21st Century Oncology-Henderson
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Nevada Cancer Research Foundation NCORP
  - Las Vegas, Nevada, Forenede Stater, 89109
    - 21st Century Oncology
  - Las Vegas, Nevada, Forenede Stater, 89128
    - 21st Century Oncology-Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148
    - 21st Century Oncology-Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Women's Cancer Center of Nevada
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89502
    - Center of Hope at Renown Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - Neptune, New Jersey, Forenede Stater, 07753
    - Jersey Shore Medical Center
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Paramus, New Jersey, Forenede Stater, 07652
    - The Valley Hospital-Luckow Pavilion
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Hospital
  - Sparta, New Jersey, Forenede Stater, 07871
    - Sparta Cancer Treatment Center
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
  - Voorhees, New Jersey, Forenede Stater, 08043
    - MD Anderson Cancer Center at Cooper-Voorhees
  - Westwood, New Jersey, Forenede Stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Southwest Gynecologic Oncology Associates Inc
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
- New York
  - Albany, New York, Forenede Stater, 12208
    - Women's Cancer Care Associates LLC
  - Brightwaters, New York, Forenede Stater, 11718
    - Island Gynecologic Oncology
  - Brooklyn, New York, Forenede Stater, 11203
    - State University of New York Downstate Medical Center
  - Canandaigua, New York, Forenede Stater, 14424
    - Sands Cancer Center
  - Fresh Meadows, New York, Forenede Stater, 11365
    - New York Hospital Medical Center of Queens
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health NCORP
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forenede Stater, 11030
    - North Shore University Hospital
  - Mineola, New York, Forenede Stater, 11501
    - NYU Winthrop Hospital
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10003
    - Mount Sinai Union Square
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14620
    - Highland Hospital
  - Rochester, New York, Forenede Stater, 14606
    - Wilmot Cancer Institute Radiation Oncology at Greece
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Valhalla, New York, Forenede Stater, 10595
    - New York Medical College
  - Valhalla, New York, Forenede Stater, 10595
    - Westchester Medical Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Duke Raleigh Hospital
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Health System - Akron Campus
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forenede Stater, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Forenede Stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forenede Stater, 45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forenede Stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Fairfield, Ohio, Forenede Stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Lancaster Radiation Oncology
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mentor, Ohio, Forenede Stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Warren Clinic Oncology-Tulsa
- Oregon
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Memorial Hospital
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Crozer-Chester Medical Center
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
- South Carolina
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Black Hills Obstetrics and Gynecology
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Chattanooga's Program In Women's Oncology
  - Knoxville, Tennessee, Forenede Stater, 37920
    - University of Tennessee - Knoxville
  - Nashville, Tennessee, Forenede Stater, 37203
    - Tennessee Oncology PLLC- Centennial Medical Center
- Texas
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Galveston, Texas, Forenede Stater, 77555-0565
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Memorial Hermann Texas Medical Center
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Medical Center Regional Cancer Center
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
- Vermont
  - Burlington, Vermont, Forenede Stater, 05401
    - University of Vermont Medical Center
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Roanoke, Virginia, Forenede Stater, 24016
    - Carilion Clinic Gynecological Oncology
- Washington
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forenede Stater, 98226
    - PeaceHealth Medical Group PC
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison Medical Center
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital Regional Cancer Care Center
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forenede Stater, 98507
    - Capital Medical Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98109
    - Seattle Cancer Care Alliance
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98133
    - University of Washington Medical Center - Northwest
  - Sequim, Washington, Forenede Stater, 98384
    - Olympic Medical Cancer Care Center
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Compass Oncology Vancouver
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Hospital and Clinics
- West Virginia
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Bellin Memorial Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53405
    - Ascension All Saints Hospital
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Weston, Wisconsin, Forenede Stater, 54476
    - Diagnostic and Treatment Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Korea, Republikken
- - Seoul, Korea, Republikken, 110-744
    - Seoul National University Hospital
  - Seoul, Korea, Republikken, 05505
    - Asan Medical Center
  - Seoul, Korea, Republikken, 06273
    - Gangnam Severance Hospital
  - Seoul, Korea, Republikken, 139-706
    - Korea Cancer Center Hospital
  - Suwon, Korea, Republikken, 443-721
    - Ajou University Hospital
- Daegu
  - Dalseo-gu, Daegu, Korea, Republikken, 42601
    - Keimyung University-Dongsan Medical Center
- Gyeonggi-do
  - Goyang-si, Gyeonggi-do, Korea, Republikken, 410-769
    - National Cancer Center-Korea
- Korea
  - Seoul, Korea, Korea, Republikken, 135-710
    - Samsung Medical Center
  - Seoul, Korea, Korea, Republikken, 137-040
    - Catholic University of Korea-Seoul Saint Mary's Hospital
- Kyeonggi-do
  - Seongnam City, Kyeonggi-do, Korea, Republikken, 463-707
    - Seoul National University Bundang Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (VOKSEN, OLDER_ADULT)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Inklusionskriterier:

Alle patienter med kirurgisk stadium III eller IVA endometriekarcinom i henhold til FIGO 2009 stadiekriterier, herunder klarcellet og serøst papillært og udifferentieret karcinom
- Kirurgisk fase III sygdom omfatter de patienter med positiv adnexa, parametrisk involvering, tumor invaderende serosa, positive bækken og/eller para-aorta noder eller vaginal involvering
- Kirurgisk stadium IVA patienter med blære- eller tarmslimhindepåvirkning, men ingen spredning uden for bækkenet
Patienter med FIGO 2009 kirurgisk stadium I eller II endometrial klarcellet eller serøst karcinom og med positiv peritoneal cytologi
Kirurgi skal have omfattet en hysterektomi og bilateral salpingo-ooforektomi; prøvetagning af bækkenlymfeknude og para-aorta lymfeknudeprøve er valgfri
Patienter med en Gynecologic Oncology Group (GOG) præstationsstatus på 0, 1 eller 2
Hvide blodlegemer (WBC) >= 3.000/mcl
Absolut neutrofiltal (ANC) >= 1.500/mcl
Blodpladetal >= 100.000/mcl
Serumglutamin-oxaloeddikesyretransaminase (SGOT) og serumglutamatpyruvattransaminase (SGPT) =< 2,5 x øvre normalgrænse (ULN)
Alkalisk fosfatase =< 2,5 gange ULN
Bilirubin =< 1,5 gange ULN
Kreatinin =< institutionel ULN
Patienter, der har opfyldt før-adgangskravene; testværdier/resultater skal opfylde berettigelseskriterier
Patienter, der har underskrevet et godkendt informeret samtykke og autorisation, der tillader frigivelse af personlige helbredsoplysninger
Deltagelse i undersøgelsen er begrænset til højst 8 uger fra operationsdatoen

Ekskluderingskriterier:

Patienter med carcinosarkom
Patienter med tilbagevendende endometriecancer
Patienter med resterende tumor efter operationen (et hvilket som helst enkelt sted), der overstiger 2 cm i maksimal dimension
Patienter, der har fået strålebehandling af bækken eller mave
Patienter med positive bækkenvaskninger som den eneste ekstra-uterin sygdom er IKKE kvalificerede, hvis histologien er andet end klarcellet eller papillært serøst karcinom
Patienter med en anamnese med andre invasive maligniteter, med undtagelse af non-melanom hudcancer, udelukkes, hvis der er tegn på aktiv malignitet inden for de sidste fem år; patienter er også udelukket, hvis deres tidligere kræftbehandling kontraindicerer denne protokolbehandling
Patienter med en historie med alvorlig komorbid sygdom eller ukontrollerede sygdomme, der ville udelukke protokolbehandling
Patienter med en estimeret overlevelse på mindre end tre måneder
Patienter med FIGO 2009 stadium IVB endometriecancer
Patienter med parenkymale levermetastaser
Patienter, der tidligere har modtaget kemoterapi for endometriecancer
Patienter med en anamnese med myokardieinfarkt, ustabil angina eller ukontrolleret arytmi inden for 3 måneder fra indskrivning

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: BEHANDLING
Tildeling: TILFÆLDIGT
Interventionel model: PARALLEL
Maskning: INGEN

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
EKSPERIMENTEL: Arm I (cisplatin, strålebehandling, paclitaxel, carboplatin) Patienterne får cisplatin IV på dag 1 og 29. Patienterne gennemgår også strålebehandling QD, 5 dage om ugen, i 5-6 uger. Nogle patienter kan derefter gennemgå brachyterapi over 2-3 uger. Begyndende inden for 8 uger efter afslutning af kemoradioterapi får patienterne paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: Carboplatin Givet IV Andre navne: Blastocarb Carboplat Carboplatin Hexal Carboplatino Carbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatin Paraplatin Paraplatin AQ Platinwas Ribocarbo Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Cisplatin Givet IV Andre navne: CDDP Cis-diammindichloridoplatin Cismaplat Cisplatin Neoplatin Platinol Abiplatin Blastolem Briplatin Cis-diammin-dichlorplatin Cis-diammindichlor platin (II) Cis-diamindichlorplatin Cis-dichloramin Platin (II) Cis-platinøst diamin dichlorid Cis-platin Cis-platin II Cis-platin II diamin dichlorid Cisplatina Cisplatyl Citoplatino Citosin Cysplatyna DDP Lederplatin Metaplatin Peyrones klorid Peyrones salt Placis Plastistil Platamin Platiblastin Platiblastin-S Platinex Platinol-AQ Platinol-AQ VHA Plus Platinoxan Platin Platindiaminodichlorid Platiran Platistin Platosin Medicin: Paclitaxel Givet IV Andre navne: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Stråling: Stråleterapi Gennemgå strålebehandling Andre navne: Kræftstrålebehandling Bestråle Bestrålet Stråling Radioterapeutika RT Terapi, Stråling bestråling RADIOTERAPI Stråling: Intern Stråleterapi Gennemgå brachyterapi Andre navne: Intern strålings brachyterapi Strålingsbrachyterapi BRACHYTERAPI indre stråling
ACTIVE_COMPARATOR: Arm II (paclitaxel og carboplatin) Patienterne får paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: Carboplatin Givet IV Andre navne: Blastocarb Carboplat Carboplatin Hexal Carboplatino Carbosin Carbosol Carbotec CBDCA Displata Ercar JM-8 Nealorin Novoplatin Paraplatin Paraplatin AQ Platinwas Ribocarbo Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Paclitaxel Givet IV Andre navne: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat

Deltagergruppe / Arm

Intervention / Behandling

EKSPERIMENTEL: Arm I (cisplatin, strålebehandling, paclitaxel, carboplatin)

Patienterne får cisplatin IV på dag 1 og 29. Patienterne gennemgår også strålebehandling QD, 5 dage om ugen, i 5-6 uger. Nogle patienter kan derefter gennemgå brachyterapi over 2-3 uger. Begyndende inden for 8 uger efter afslutning af kemoradioterapi får patienterne paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 4 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Medicin: Carboplatin

Givet IV

Andre navne:

Blastocarb
Carboplat
Carboplatin Hexal
Carboplatino
Carbosin
Carbosol
Carbotec
CBDCA
Displata
Ercar
JM-8
Nealorin
Novoplatin
Paraplatin
Paraplatin AQ
Platinwas
Ribocarbo

Andet: Livskvalitetsvurdering

Hjælpestudier

Andre navne:

Livskvalitetsvurdering

Medicin: Cisplatin

Givet IV

Andre navne:

CDDP
Cis-diammindichloridoplatin
Cismaplat
Cisplatin
Neoplatin
Platinol
Abiplatin
Blastolem
Briplatin
Cis-diammin-dichlorplatin
Cis-diammindichlor platin (II)
Cis-diamindichlorplatin
Cis-dichloramin Platin (II)
Cis-platinøst diamin dichlorid
Cis-platin
Cis-platin II
Cis-platin II diamin dichlorid
Cisplatina
Cisplatyl
Citoplatino
Citosin
Cysplatyna
DDP
Lederplatin
Metaplatin
Peyrones klorid
Peyrones salt
Placis
Plastistil
Platamin
Platiblastin
Platiblastin-S
Platinex
Platinol-AQ
Platinol-AQ VHA Plus
Platinoxan
Platin
Platindiaminodichlorid
Platiran
Platistin
Platosin

Medicin: Paclitaxel

Givet IV

Andre navne:

Taxol
Anzatax
Asotax
Bristaxol
Praxel
Taxol Konzentrat

Stråling: Stråleterapi

Gennemgå strålebehandling

Andre navne:

Kræftstrålebehandling
Bestråle
Bestrålet
Stråling
Radioterapeutika
RT
Terapi, Stråling
bestråling
RADIOTERAPI

Stråling: Intern Stråleterapi

Gennemgå brachyterapi

Andre navne:

Intern strålings brachyterapi
Strålingsbrachyterapi
BRACHYTERAPI
indre stråling

ACTIVE_COMPARATOR: Arm II (paclitaxel og carboplatin)

Patienterne får paclitaxel IV over 3 timer og carboplatin IV på dag 1. Behandlingen gentages hver 21. dag i 6 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Medicin: Carboplatin

Givet IV

Andre navne:

Blastocarb
Carboplat
Carboplatin Hexal
Carboplatino
Carbosin
Carbosol
Carbotec
CBDCA
Displata
Ercar
JM-8
Nealorin
Novoplatin
Paraplatin
Paraplatin AQ
Platinwas
Ribocarbo

Andet: Livskvalitetsvurdering

Hjælpestudier

Andre navne:

Livskvalitetsvurdering

Medicin: Paclitaxel

Givet IV

Andre navne:

Taxol
Anzatax
Asotax
Bristaxol
Praxel
Taxol Konzentrat

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med gentagelse, progression eller død Tidsramme: Sygdommen skulle vurderes ved baseline, afslutning af behandlingen og hver 6. måned i to år og årligt op til 5 år.	Antal deltagere tilmeldt med recidiv eller progression af sygdom eller død op til dato for sidste kontakt. Progression defineres ved hjælp af Response Evaluation Criteria in Solid Tumors Criteria (RECIST v1.0) som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner.	Sygdommen skulle vurderes ved baseline, afslutning af behandlingen og hver 6. måned i to år og årligt op til 5 år.

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med akutte bivirkninger som klassificeret af National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events Version (CTCAE) Version 3.0 Tidsramme: Vurderes i hele behandlingsperioden og i 21-30 dage efter seponering af behandlingen	Den maksimale karakter af alle behandlingsfremkomne bivirkninger uden hensyntagen til tilskrivning. Generelle retningslinjer for sværhedsgraden af bivirkninger er som følger: Grad 1 er mild, grad 2 er moderat, grad 3 er svær, grad 4 er livstruende og grad 5 er død.	Vurderes i hele behandlingsperioden og i 21-30 dage efter seponering af behandlingen
Antal deltagere med sene uønskede hændelser som bedømt af NCI CTCAE Version 3.0 Tidsramme: Vurderes hver 6. måned i 3 år	Den maksimale grad af uønskede hændelser rapporteret under opfølgning indtil sygdomsprogression, ændring af terapi eller på anden måde uden for studiet i maksimalt 3 år uden hensyntagen til tilskrivning. Generelle retningslinjer for sværhedsgraden af bivirkninger er som følger: Grad 1 er mild, grad 2 er moderat, grad 3 er svær, grad 4 er livstruende og grad 5 er død.	Vurderes hver 6. måned i 3 år
Samlet overlevelse Tidsramme: Fra indtræden i undersøgelsen til død eller dato for sidste kontakt, vurderet op til 8 år	Uafhængighed mellem de to endepunkter, RFS og overlevelse, og randomiseret behandling vil blive vurderet med en stratificeret logrank test til en intention-to-treat-analyse af kvalificerede patienter.	Fra indtræden i undersøgelsen til død eller dato for sidste kontakt, vurderet op til 8 år
Patientrapporterede symptomer på perifer neuropati Tidsramme: Før studiebehandling (baseline), arm 1: 1 uge efter afslutning af strålebehandling, arm 2: Før cyklus 3 (6 uger efter start af studiebehandling), 18 uger efter start af studiebehandling, 70 uger efter start af studiebehandling	Patientrapporterede symptomer på perifer neuropati blev målt med Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - neurotoksicitetsunderskala (kort version) (FACT/GOG-Ntx underskala). FACT/GOG-Ntx underskalaen indeholder 4 punkter. Hvert element blev scoret ved hjælp af en 5-punkts skala (0=slet ikke; 1=en lille smule; 2=noget; 3=en smule; 4=meget). For de negative poster blev tilbageførsel udført før scoreberegning. Ifølge FACIT-målesystemet var Ntx-scoren summeringen af de enkelte emnescores, hvis mere end 50 % af underskalapunkterne blev besvaret. Når der fandtes ubesvarede emner, blev en underskala-score forholdsmæssigt fordelt ved at gange gennemsnittet af de besvarede emnescores med antallet af emner i skalaen. Ntx-scoren spænder fra 0-16 med en høj score tyder på færre perifere neuropati-symptomer.	Før studiebehandling (baseline), arm 1: 1 uge efter afslutning af strålebehandling, arm 2: Før cyklus 3 (6 uger efter start af studiebehandling), 18 uger efter start af studiebehandling, 70 uger efter start af studiebehandling
Patientrapporteret livskvalitet (QOL) Tidsramme: Før studiebehandling (baseline), arm 1: 1 uge efter afslutning af strålebehandling, arm 2: Før cyklus 3 (6 uger efter start af studiebehandling), 18 uger efter start af studiebehandling, 70 uger efter start af studiebehandling	Patientrapporteret livskvalitet blev målt med Treatment Outcome Index of the Functional Assessment of Cancer Therapy for endometriecancer (FACT-En TOI). Det er en skala til vurdering af generel QOL for endometriecancerpatienter. Den består af tre underskalaer: Fysisk velvære (7 punkter), Funktionel velvære (7 punkter) og Endometriumcancer-underskalaen (16 punkter). Hvert element blev scoret ved hjælp af en 5-punkts skala (0=slet ikke; 1=en lille smule; 2=noget; 3=en smule; 4=meget). Ifølge FACIT-målesystemet var en subskala-score summeringen af de enkelte item-scores, hvis mere end 50 % af subskala-punkterne blev besvaret. Når der fandtes ubesvarede emner, blev en underskala-score forholdsmæssigt fordelt ved at gange gennemsnittet af de besvarede emnescores med antallet af emner i underskalaen. FACT-En TOI-scoren beregnes som summen af subskala-scorerne, intervaller er 0-120 med en høj score, der tyder på en bedre QOL.	Før studiebehandling (baseline), arm 1: 1 uge efter afslutning af strålebehandling, arm 2: Før cyklus 3 (6 uger efter start af studiebehandling), 18 uger efter start af studiebehandling, 70 uger efter start af studiebehandling

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Gynecologic Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Daniela E Matei, NRG Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (FAKTISKE)

29. juni 2009

Primær færdiggørelse (FAKTISKE)

15. februar 2016

Studieafslutning (FORVENTET)

28. juli 2024

Datoer for studieregistrering

Først indsendt

17. juli 2009

Først indsendt, der opfyldte QC-kriterier

17. juli 2009

Først opslået (SKØN)

20. juli 2009

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

19. oktober 2021

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. september 2021

Sidst verificeret

1. september 2021

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

GOG-0258 (ANDET: CTEP)
U10CA180868 (U.S. NIH-bevilling/kontrakt)
U10CA027469 (U.S. NIH-bevilling/kontrakt)
NCI-2011-01951 (REGISTRERING: CTRP (Clinical Trial Reporting Program))
10-00685
CDR0000649079

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Carboplatin og Paclitaxel med eller uden cisplatin og strålebehandling til behandling af patienter med trin I, trin II, trin III eller stadium IVA endometriecancer

Et randomiseret fase III-forsøg med cisplatin og tumorvolumen rettet bestråling efterfulgt af carboplatin og paclitaxel vs. carboplatin og paclitaxel til optimalt debulk, avanceret endometriekarcinom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (FAKTISKE)

Primær færdiggørelse (FAKTISKE)

Studieafslutning (FORVENTET)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (SKØN)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre