S0819: Carboplatin og Paclitaxel med eller uden Bevacizumab og/eller Cetuximab til behandling af patienter med stadium IV eller tilbagevendende ikke-småcellet lungekræft
19. maj 2023 opdateret af: SWOG Cancer Research Network
Et randomiseret, fase III-studie, der sammenligner Carboplatin/Paclitaxel eller Carboplatin/Paclitaxel/Bevacizumab med eller uden samtidig Cetuximab hos patienter med avanceret ikke-småcellet lungekræft (NSCLC)
Dette randomiserede fase III-forsøg undersøger carboplatin og paclitaxel for at sammenligne, hvor godt de virker med eller uden bevacizumab og/eller cetuximab til behandling af patienter med stadium IV eller ikke-småcellet lungekræft, der er vendt tilbage efter en periode med bedring (tilbagevendende).
Lægemidler, der bruges i kemoterapi, såsom carboplatin og paclitaxel, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig.
Bevacizumab kan forhindre væksten af nye blodkar, som tumor har brug for for at vokse.
Cetuximab kan også stoppe kræftceller i at vokse ved at binde og interferere med et protein på overfladen af tumorcellen, som er nødvendigt for tumorvækst.
Det vides endnu ikke, om det at give carboplatin og paclitaxel er mere effektivt med eller uden bevacizumab og/eller cetuximab til behandling af patienter med ikke-småcellet lungecancer.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. At sammenligne overordnet overlevelse (OS) i hele undersøgelsespopulationen. II. At sammenligne progressionsfri overlevelse (PFS) ved institutionel gennemgang af epidermal vækstfaktorreceptor (EGFR) fluorescerende in situ hybridisering (FISH)-positive patienter.
SEKUNDÆRE MÅL:
I. At sammenligne OS og PFS ved centraliseret gennemgang hos EGFR FISH-positive patienter. II. At sammenligne PFS ved centraliseret billedgennemgang og ved institutionel gennemgang i hele undersøgelsespopulationen.
III. At sammenligne responsraten (bekræftet plus ubekræftede, fuldstændige og delvise responser) i en undergruppe af patienter med målbar sygdom hos EGFR FISH-positive patienter og hele undersøgelsespopulationen.
IV. At vurdere toksiciteten af disse behandlingsregimer. V. At prospektivt teste EGFR FISH som en prædiktiv markør for udvælgelsen af patienter til cetuximab plus kemoterapi.
III. For at evaluere rollen af V-Ki-ras2 Kirsten rottesarkom viral onkogen homolog (KRAS) mutationer med hensyn til cetuximabs effektivitet.
IV. At sammenligne resultaterne af EGFR FISH med KRAS-mutationer, EGFR-mutationer, EGFR-immunhistokemi (IHC) og andre påståede EGFR-relaterede biomarkører.
TERTIÆRE MÅL:
I. At sammenligne PFS hos patienter med fremskreden ikke-småcellet lungecancer (NSCLC) med en IHC-score > 200 behandlet med carboplatin, paclitaxel og bevacizumab (hvis relevant) med eller uden cetuximab.
II. At sammenligne OS hos patienter med fremskreden NSCLC med en IHC-score > 200 behandlet med carboplatin, paclitaxel og bevacizumab (hvis relevant) med eller uden cetuximab.
OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.
ARM I: Patienterne får paclitaxel intravenøst (IV) over 3 timer og carboplatin IV over 30 minutter med eller uden bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i op til 6 kure i fravær af sygdomsprogression eller uacceptabel toksicitet. Efter afslutning af 6 kure kan patienter, der får bevacizumab, fortsætte med at modtage bevacizumab (som ovenfor) i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM II: Patienter får paclitaxel og carboplatin med eller uden bevacizumab som i arm I. Patienter får også cetuximab IV over 1-2 timer på dag 1, 8 og 15. Behandlingen gentages hver 21. dag i op til 6 kure i fravær af sygdomsprogression eller uacceptabel toksicitet. Efter afslutning af 6 kure kan patienter fortsætte med at modtage cetuximab med eller uden bevacizumab (som ovenfor) i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i 1 år og derefter hver 6. måned i 2 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
1333
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Anniston, Alabama, Forenede Stater, 36202
- Northeast Alabama Regional Medical Center
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Mobile, Alabama, Forenede Stater, 36608
- Providence Hospital
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Mobile, Alabama, Forenede Stater, 36604
- Gulf Coast MBCCOP
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Alaska
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Regional Hospital
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Tucson, Arizona, Forenede Stater, 85724
- The University of Arizona Medical Center-University Campus
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Tucson, Arizona, Forenede Stater, 85719
- The University of Arizona Cancer Center-North Campus
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Tucson, Arizona, Forenede Stater, 85704
- The University of Arizona Cancer Center-Orange Grove Campus
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Arkansas
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Jonesboro, Arkansas, Forenede Stater, 72401
- Fowler Family Center for Cancer Care
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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California
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Antioch, California, Forenede Stater, 94531
- East Bay Medical Oncology Hematology Medical Associates-Antioch
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Forenede Stater, 94010
- Mills - Peninsula Hospitals
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Forenede Stater, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Chico, California, Forenede Stater, 95926
- Enloe Medical Center
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Fairfield, California, Forenede Stater, 94533
- Northbay Cancer Center
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Fremont, California, Forenede Stater, 94538
- Valley Medical Oncology Consultants-Fremont
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Greenbrae, California, Forenede Stater, 94904
- Marin General Hospital
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Loma Linda, California, Forenede Stater, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- Los Angeles County-USC Medical Center
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Marysville, California, Forenede Stater, 95901
- Fremont - Rideout Cancer Center
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Mather, California, Forenede Stater, 95655
- Mather Veteran Affairs Medical Center
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Merced, California, Forenede Stater, 95340
- Mercy UC Davis Cancer Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Mountain View, California, Forenede Stater, 94040
- El Camino Hospital
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94602
- Highland General Hospital
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Oakland, California, Forenede Stater, 94609
- Larry G Strieff MD Medical Corporation
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Oakland, California, Forenede Stater, 94609
- Tom K Lee Inc
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Orange, California, Forenede Stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Pasadena, California, Forenede Stater, 91105
- Keck Medical Center of USC Pasadena
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Pleasant Hill, California, Forenede Stater, 94523
- East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
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Pleasant Hill, California, Forenede Stater, 94523
- Diablo Valley Oncology and Hematology Medical Group-Pleasant Hill
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Pleasanton, California, Forenede Stater, 94588
- Valley Care Health System - Pleasanton
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Pleasanton, California, Forenede Stater, 94588
- Valley Medical Oncology Consultants
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95816
- Sutter General Hospital
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Saint Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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San Diego, California, Forenede Stater, 92103
- University of California San Diego
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San Francisco, California, Forenede Stater, 94118
- California Pacific Medical Center-Pacific Campus
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San Leandro, California, Forenede Stater, 94578
- East Bay Medical Oncology Hematology Associates Inc
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San Pablo, California, Forenede Stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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Truckee, California, Forenede Stater, 96161
- Tahoe Forest Cancer Center
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Whittier, California, Forenede Stater, 90602
- Presbyterian Intercommunity Hospital
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Colorado
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Alamosa, Colorado, Forenede Stater, 81101
- San Luis Valley Regional Medical Center
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forenede Stater, 80909
- Memorial Hospital Colorado Springs
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Exempla Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80907
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80204
- Denver Health Medical Center
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Denver, Colorado, Forenede Stater, 80224-2522
- Colorado Cancer Research Program CCOP
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Denver, Colorado, Forenede Stater, 80220
- Denver Veterans Administration Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Edwards, Colorado, Forenede Stater, 81632
- The Shaw Regional Cancer Center
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Englewood, Colorado, Forenede Stater, 80113
- Comprehensive Cancer Care and Research Institute of Colorado LLC
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Glenwood Springs, Colorado, Forenede Stater, 81601
- Valley View Hospital Cancer Center
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Golden, Colorado, Forenede Stater, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Greenwood Village, Colorado, Forenede Stater, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Parker, Colorado, Forenede Stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forenede Stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Forenede Stater, 80033
- Exempla Lutheran Medical Center
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06105
- Saint Francis Hospital and Medical Center
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New Haven, Connecticut, Forenede Stater, 06520
- Yale University
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Medical Center at Kent General
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Newark, Delaware, Forenede Stater, 19713
- Christiana Gynecologic Oncology LLC
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Newark, Delaware, Forenede Stater, 19713
- Regional Hematology and Oncology PA
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- Nanticoke Memorial Hospital
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Florida
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Boca Raton, Florida, Forenede Stater, 33486
- Boca Raton Regional Hospital
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Daytona Beach, Florida, Forenede Stater, 32117
- Florida Hospital Memorial Medical Center
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Deerfield Beach, Florida, Forenede Stater, 33064
- Broward Health North
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Gainesville, Florida, Forenede Stater, 32605
- Gainesville Hematology Oncology Associates
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Jupiter, Florida, Forenede Stater, 33458
- Jupiter Medical Center
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Orange Park, Florida, Forenede Stater, 32073
- 21st Century Oncology-Orange Park
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Pensacola, Florida, Forenede Stater, 32504
- Sacred Heart Hospital
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Pensacola, Florida, Forenede Stater, 32514
- Sacred Heart Medical Oncology Group - Davis Highway
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Georgia
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Albany, Georgia, Forenede Stater, 31701
- Phoebe Putney Memorial Hospital
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Athens, Georgia, Forenede Stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forenede Stater, 30309
- Piedmont Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Saint Joseph's Hospital of Atlanta
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Atlanta, Georgia, Forenede Stater, 30342
- Atlanta Regional CCOP
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Augusta, Georgia, Forenede Stater, 30912
- Georgia Regents University Medical Center
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Austell, Georgia, Forenede Stater, 30106
- Well Star Cobb Hospital
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Forenede Stater, 30033
- Dekalb Medical Center
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Fayetteville, Georgia, Forenede Stater, 30214
- Piedmont Fayette Hospital
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Lawrenceville, Georgia, Forenede Stater, 30045
- Gwinnett Medical Center
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Marietta, Georgia, Forenede Stater, 30060
- Wellstar Kennestone Hospital
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Riverdale, Georgia, Forenede Stater, 30274
- Southern Regional Medical Center
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Rome, Georgia, Forenede Stater, 30165
- Harbin Clinic Medical Oncology and Clinical Research
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Savannah, Georgia, Forenede Stater, 31404
- Memorial University Medical Center
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96859
- Tripler Army Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Oncare Hawaii Inc-POB II
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Honolulu, Hawaii, Forenede Stater, 96817-3169
- OnCare Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Oncare Hawaii Inc-Kuakini
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Wailuku, Hawaii, Forenede Stater, 96793
- Maui Memorial Medical Center
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Wailuku, Hawaii, Forenede Stater, 96793
- Pacific Cancer Institute of Maui
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Lewiston, Idaho, Forenede Stater, 83501
- Saint Joseph Regional Medical Center
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Cancer Center
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, Forenede Stater, 61520
- Graham Hospital Association
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, Forenede Stater, 62321
- Memorial Hospital
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60612
- University of Illinois
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Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Forenede Stater, 60640
- Weiss Memorial Hospital
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Chicago, Illinois, Forenede Stater, 60631
- Resurrection Healthcare
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Chicago, Illinois, Forenede Stater, 60612
- Jesse Brown Veterans Affairs Medical Center
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Center of Decatur
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Decatur, Illinois, Forenede Stater, 62526
- Central Illinois CCOP
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Elgin, Illinois, Forenede Stater, 60123
- Advocate Sherman Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, Forenede Stater, 61530
- Eureka Hospital
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Evanston, Illinois, Forenede Stater, 60202
- Saint Francis Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Galesburg Cottage Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare Galesburg
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg Cottage Plaza Office
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Geneva, Illinois, Forenede Stater, 60134
- Cadence Cancer Center at Delnor
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Havana, Illinois, Forenede Stater, 62644
- Mason District Hospital
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Havana, Illinois, Forenede Stater, 62644
- Illinois CancerCare-Havana
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Hines, Illinois, Forenede Stater, 60141
- Hines Veterans Administration Hospital
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Joliet, Illinois, Forenede Stater, 60435
- Joliet Oncology-Hematology Associates Limited
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Kankakee, Illinois, Forenede Stater, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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La Grange, Illinois, Forenede Stater, 60525
- Adventist La Grange Memorial Hospital
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, Forenede Stater, 61455
- Mcdonough District Hospital
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Porubcin, Michael MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Monmouth, Illinois, Forenede Stater, 61462
- Illinois CancerCare-Monmouth
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Monmouth, Illinois, Forenede Stater, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
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Normal, Illinois, Forenede Stater, 61761
- Community Cancer Center Foundation
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Normal, Illinois, Forenede Stater, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, Forenede Stater, 61761
- Illinois CancerCare-Community Cancer Center
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Normal, Illinois, Forenede Stater, 61761
- Mid-Illinois Hematology Oncology Associates
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Forenede Stater, 61350
- Radiation Oncology of Northern Illinois
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Ottawa, Illinois, Forenede Stater, 61350
- Ottawa Regional Hospital and Healthcare Center
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Forenede Stater, 61554
- Pekin Cancer Treatment Center
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Pekin, Illinois, Forenede Stater, 61554
- Pekin Hospital
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Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Forenede Stater, 61614
- Proctor Hospital
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Peoria, Illinois, Forenede Stater, 61603
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61615-7827
- OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
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Peoria, Illinois, Forenede Stater, 61615
- Illinois Oncology Research Association CCOP
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Peru, Illinois, Forenede Stater, 61354
- Illinois Valley Hospital
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Princeton, Illinois, Forenede Stater, 61356
- Perry Memorial Hospital
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River Forest, Illinois, Forenede Stater, 60305
- West Suburban Medical Center
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Rockford, Illinois, Forenede Stater, 61114
- SwedishAmerican Regional Cancer Center/ACT
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Spring Valley, Illinois, Forenede Stater, 61362
- Saint Margaret's Hospital
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Spring Valley, Illinois, Forenede Stater, 61362
- Illinois CancerCare-Spring Valley
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Springfield, Illinois, Forenede Stater, 62781-0001
- Memorial Medical Center
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Warrenville, Illinois, Forenede Stater, 60555
- Cadence Cancer Center in Warrenville
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Indiana
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Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Forenede Stater, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Forenede Stater, 46514-2098
- Elkhart Clinic
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
-
Indianapolis, Indiana, Forenede Stater, 46219
- IU Health Central Indiana Cancer Centers-East
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forenede Stater, 46350
- IU Health La Porte Hospital
-
Lafayette, Indiana, Forenede Stater, 47904
- IU Health Arnett Cancer Care
-
Merrillville, Indiana, Forenede Stater, 46410
- Premier Oncology Hematology Associates
-
Mishawaka, Indiana, Forenede Stater, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Forenede Stater, 46545
- Cancer Care Partners LLC
-
Mishawaka, Indiana, Forenede Stater, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Plymouth, Indiana, Forenede Stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Hospital and Health Care Services
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, Forenede Stater, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, Forenede Stater, 46617
- South Bend Clinic
-
South Bend, Indiana, Forenede Stater, 46628
- Northern Indiana Cancer Research Consortium CCOP
-
Westville, Indiana, Forenede Stater, 46391
- Michiana Hematology Oncology-PC Westville
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic PC-William R Bliss Cancer Center
-
Bettendorf, Iowa, Forenede Stater, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic PC-Boone
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Cedar Rapids Oncology Association
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Des Moines, Iowa, Forenede Stater, 50307
- Mercy Capitol
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Oncology Research Association CCOP
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic PC-Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic PC-Marshalltown
-
Mason City, Iowa, Forenede Stater, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, Forenede Stater, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Forenede Stater, 51104
- Saint Luke's Regional Medical Center
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Hematology Oncology Associates
-
Sioux City, Iowa, Forenede Stater, 51104
- Mercy Medical Center-Sioux City
-
West Des Moines, Iowa, Forenede Stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Emporia, Kansas, Forenede Stater, 66801
- Newman Regional Health
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Forenede Stater, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Forenede Stater, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Forenede Stater, 67601
- Hays Medical Center
-
Hutchinson, Kansas, Forenede Stater, 67502
- Hutchinson Regional Medical Center
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Forenede Stater, 66112
- Kansas City Cancer Center-West
-
Kansas City, Kansas, Forenede Stater, 66112
- Providence Medical Center
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67901
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forenede Stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Cancer Center
-
Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Forenede Stater, 66213
- Saint Luke's South Hospital
-
Overland Park, Kansas, Forenede Stater, 66210
- Kansas City Cancer Centers-Southwest
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forenede Stater, 66762
- Via Christi Hospital-Pittsburg
-
Prairie Village, Kansas, Forenede Stater, 66208
- Kansas City CCOP
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Shawnee Mission, Kansas, Forenede Stater, 66204
- Shawnee Mission Medical Center
-
Shawnee Mission, Kansas, Forenede Stater, 66204
- Kansas City Cancer Center-Shawnee Mission
-
Topeka, Kansas, Forenede Stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Topeka, Kansas, Forenede Stater, 66604
- Stormont-Vail Regional Health Center
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Main Office
-
Wichita, Kansas, Forenede Stater, 67214
- Via Christi Regional Medical Center
-
Wichita, Kansas, Forenede Stater, 67214
- Wesley Medical Center
-
Wichita, Kansas, Forenede Stater, 67214
- Wichita CCOP
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Crestview Hills, Kentucky, Forenede Stater, 41017
- Oncology Hematology Care Inc-Crestview
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Forenede Stater, 70806
- Baton Rouge General Medical Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Hematology/Oncology Clinic LLP
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Health Center-Covington
-
Metairie, Louisiana, Forenede Stater, 70006
- Robert Veith MD LLC
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- Tulane University Health Sciences Center
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, Forenede Stater, 70112
- Interim LSU Public Hospital
-
New Orleans, Louisiana, Forenede Stater, 70115
- Ochsner Baptist Medical Center
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Forenede Stater, 21202
- Mercy Medical Center
-
Baltimore, Maryland, Forenede Stater, 21237
- Franklin Square Hospital Center
-
Elkton, Maryland, Forenede Stater, 21921
- Union Hospital of Cecil County
-
Silver Spring, Maryland, Forenede Stater, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, Forenede Stater, 01915
- Beverly Hospital
-
Brighton, Massachusetts, Forenede Stater, 02135-2997
- Caritas Saint Elizabeth's Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Methuen, Massachusetts, Forenede Stater, 01844
- Holy Family Hospital
-
Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Hematology Oncology PC
-
-
Michigan
-
Adrian, Michigan, Forenede Stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106-0995
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Michigan Cancer Research Consortium CCOP
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Bay City, Michigan, Forenede Stater, 48708
- McLaren-Bay Region
-
Big Rapids, Michigan, Forenede Stater, 49307
- Spectrum Health Big Rapids Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Great Lakes Cancer Institute
-
Dearborn, Michigan, Forenede Stater, 48124
- Oakwood Hospital and Medical Center
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Saint John Hospital and Medical Center
-
Detroit, Michigan, Forenede Stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Escanaba, Michigan, Forenede Stater, 49431
- Green Bay Oncology - Escanaba
-
Farmington Hills, Michigan, Forenede Stater, 48334
- Weisberg Cancer Treatment Center
-
Flint, Michigan, Forenede Stater, 48502
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, Forenede Stater, 48532
- McLaren Cancer Institute-Flint
-
Flint, Michigan, Forenede Stater, 48532
- Singh and Arora Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Blanc, Michigan, Forenede Stater, 48439
- Genesys Regional Medical Center
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Mercy Health Saint Mary's
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Grand Rapids Clinical Oncology Program
-
Iron Mountain, Michigan, Forenede Stater, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49001
- Borgess Medical Center
-
Lansing, Michigan, Forenede Stater, 48912
- Sparrow Hospital
-
Lansing, Michigan, Forenede Stater, 48910
- McLaren-Greater Lansing
-
Lapeer, Michigan, Forenede Stater, 48446
- Great Lakes Cancer Institute-Lapeer Campus
-
Livonia, Michigan, Forenede Stater, 48154
- Saint Mary Mercy Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Community Cancer Center of Monroe
-
Mount Clemens, Michigan, Forenede Stater, 48043
- McLaren-Macomb
-
Mount Pleasant, Michigan, Forenede Stater, 48858
- McLaren-Central Michigan
-
Muskegon, Michigan, Forenede Stater, 49444
- Mercy Health Mercy Campus
-
Petoskey, Michigan, Forenede Stater, 49770
- Northern Michigan Regional Hospital
-
Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, Forenede Stater, 48060
- Saint Joseph Mercy Port Huron
-
Reed City, Michigan, Forenede Stater, 49677
- Spectrum Health Reed City Hospital
-
Saginaw, Michigan, Forenede Stater, 48601
- Saint Mary's of Michigan
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Hospital
-
Southfield, Michigan, Forenede Stater, 48075
- Providence Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Wyoming, Michigan, Forenede Stater, 49519
- Metro Health Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Clinic North-Bemidgi
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Mankato, Minnesota, Forenede Stater, 56001
- Mayo Clinic Health Systems-Mankato
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Metro-Minnesota NCI Community Oncology Research Program
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology and Hematology PA-Woodbury
-
-
Mississippi
-
Hattiesburg, Mississippi, Forenede Stater, 39404
- Forest General Hospital
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
Pascagoula, Mississippi, Forenede Stater, 39581
- Singing River Hospital
-
-
Missouri
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center-Carrie J Babb Cancer Center
-
Branson, Missouri, Forenede Stater, 65616
- CoxHealth Cancer Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Columbia, Missouri, Forenede Stater, 65212
- University of Missouri - Ellis Fischel
-
Independence, Missouri, Forenede Stater, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Medical Center-Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital-Joplin
-
Kansas City, Missouri, Forenede Stater, 64128
- Kansas City Veterans Affairs Medical Center
-
Kansas City, Missouri, Forenede Stater, 64116
- North Kansas City Hospital
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Center
-
Kansas City, Missouri, Forenede Stater, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Cancer Institute
-
Kansas City, Missouri, Forenede Stater, 64114
- Saint Joseph Health Center
-
Kansas City, Missouri, Forenede Stater, 64131
- Kansas City Cancer Center - South
-
Kansas City, Missouri, Forenede Stater, 64154
- Kansas City Cancer Centers - North
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Lee's Summit, Missouri, Forenede Stater, 64064
- Kansas City Cancer Center-Lee's Summit
-
Liberty, Missouri, Forenede Stater, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, Forenede Stater, 65401
- Phelps County Regional Medical Center
-
Rolla, Missouri, Forenede Stater, 65401
- Saint John's Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Joseph, Missouri, Forenede Stater, 64507
- Saint Joseph Oncology Inc
-
Saint Louis, Missouri, Forenede Stater, 63110
- Saint Louis University Hospital
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, Forenede Stater, 63141
- Saint John's Mercy Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, Forenede Stater, 63141
- Center for Cancer Care and Research
-
Saint Louis, Missouri, Forenede Stater, 63141
- Comprehensive Cancer Care PC
-
Saint Louis, Missouri, Forenede Stater, 63136
- Christian Hospital Northeast - Northwest
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, Forenede Stater, 59101
- Montana Cancer Consortium CCOP
-
Billings, Montana, Forenede Stater, 59102
- Frontier Cancer Center and Blood Institute-Billings
-
Billings, Montana, Forenede Stater, 59107
- Billings Clinic Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forenede Stater, 59405
- Berdeaux, Donald MD (UIA Investigator)
-
Great Falls, Montana, Forenede Stater, 59405
- Big Sky Oncology
-
Havre, Montana, Forenede Stater, 59501
- Northern Montana Hospital
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, Forenede Stater, 59801
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- CHI Health Saint Francis
-
North Platte, Nebraska, Forenede Stater, 69103
- Great Plains Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68198
- University of Nebraska Medical Center
-
-
Nevada
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- 21st Century Oncology - Henderson
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forenede Stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forenede Stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forenede Stater, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Forenede Stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forenede Stater, 89148
- Cancer and Blood Specialists-Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89106
- Nevada Cancer Research Foundation CCOP
-
Las Vegas, Nevada, Forenede Stater, 89148
- 21st Century Oncology - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89182
- 21st Century Oncology - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89109
- Children's Specialty Center of Nevada II
-
Las Vegas, Nevada, Forenede Stater, 89109
- 21st Century Oncology - Vegas Sunrise
-
Las Vegas, Nevada, Forenede Stater, 89135
- Nevada Cancer Institute-Summerlin Campus
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
Reno, Nevada, Forenede Stater, 89503
- Alpine Hematology-Oncology
-
Reno, Nevada, Forenede Stater, 89519
- Reno Oncology Consultants
-
-
New Jersey
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
East Orange, New Jersey, Forenede Stater, 07018-1095
- Veterans Adminstration New Jersey Health Care System
-
Flemington, New Jersey, Forenede Stater, 08822
- Hunterdon Medical Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
-
Sewell, New Jersey, Forenede Stater, 08080
- Kennedy Health Systems-Cancer Center
-
Somerville, New Jersey, Forenede Stater, 08876
- Robert Wood Johnson University Hospital Somerset
-
Voorhees, New Jersey, Forenede Stater, 08043
- MD Anderson Cancer Center at Cooper-Voorhees
-
Voorhees, New Jersey, Forenede Stater, 08043
- Virtua West Jersey Hospital Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico
-
-
New York
-
Brooklyn, New York, Forenede Stater, 11235
- Coney Island Hospital
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Elmira, New York, Forenede Stater, 14905
- Arnot Ogden Medical Center
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Mineola, New York, Forenede Stater, 11501
- Winthrop University Hospital
-
New York, New York, Forenede Stater, 10032
- Columbia University Medical Center
-
Nyack, New York, Forenede Stater, 10960
- Nyack Hospital
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Rochester, New York, Forenede Stater, 14620
- Highland Hospital
-
Rochester, New York, Forenede Stater, 14623
- Interlakes Foundation Inc-Rochester
-
Staten Island, New York, Forenede Stater, 10305
- Staten Island University Hospital
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Forenede Stater, 13210
- Syracuse Veterans Administration Medical Center
-
Utica, New York, Forenede Stater, 13502
- Faxton-Saint Luke's Healthcare
-
-
North Carolina
-
Burlington, North Carolina, Forenede Stater, 27216
- Cone Health Cancer Center at Alamance Regional
-
Charlotte, North Carolina, Forenede Stater, 28203
- Carolinas Medical Center
-
Concord, North Carolina, Forenede Stater, 28025
- Carolinas Medical Center - Northeast
-
Gastonia, North Carolina, Forenede Stater, 28054
- Gaston Memorial Hospital
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Forenede Stater, 28792
- Park Ridge Hospital Breast Health Center
-
Kinston, North Carolina, Forenede Stater, 28501
- Kinston Medical Specialists PA
-
Monroe, North Carolina, Forenede Stater, 28112
- Carolinas Medical Center-Union
-
Rutherfordton, North Carolina, Forenede Stater, 28139
- Rutherford Hospital
-
Shelby, North Carolina, Forenede Stater, 28150
- Cleveland Regional Medical Center
-
Statesville, North Carolina, Forenede Stater, 28677
- Iredell Memorial Hospital
-
Winston-Salem, North Carolina, Forenede Stater, 27104
- Southeast Cancer Control Consortium CCOP
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, Forenede Stater, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Clinic North-Fargo
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Medical Center-Fargo
-
Fargo, North Dakota, Forenede Stater, 58122
- Roger Maris Cancer Center
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
Minot, North Dakota, Forenede Stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Akron General Medical Center
-
Bellefontaine, Ohio, Forenede Stater, 43311
- Mary Rutan Hospital
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Forenede Stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Forenede Stater, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Forenede Stater, 45230
- Oncology Hematology Care Inc - Anderson
-
Cincinnati, Ohio, Forenede Stater, 45219
- Oncology and Hematology Care Inc-Taft
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc - Kenwood
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Clyde, Ohio, Forenede Stater, 43410
- North Coast Cancer Care-Clyde
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forenede Stater, 43215
- Columbus CCOP
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Samaritan North Health Center
-
Dayton, Ohio, Forenede Stater, 45405
- Grandview Hospital
-
Dayton, Ohio, Forenede Stater, 45420
- Dayton CCOP
-
Dayton, Ohio, Forenede Stater, 45428
- Veteran Affairs Medical Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, Forenede Stater, 44035
- Mercy Cancer Center-Elyria
-
Elyria, Ohio, Forenede Stater, 44035
- Hematology Oncology Center Incorporated
-
Fairfield, Ohio, Forenede Stater, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Lima, Ohio, Forenede Stater, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Maumee, Ohio, Forenede Stater, 43537
- Saint Luke's Hospital
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Norwalk, Ohio, Forenede Stater, 44857
- Fisher-Titus Medical Center
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Steubenville, Ohio, Forenede Stater, 43952
- Trinity's Tony Teramana Cancer Center
-
Sylvania, Ohio, Forenede Stater, 43560
- Flower Hospital
-
Tiffin, Ohio, Forenede Stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43614
- University of Toledo
-
Toledo, Ohio, Forenede Stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forenede Stater, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Saint Anne Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, Forenede Stater, 43567
- Fulton County Health Center
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wilmington, Ohio, Forenede Stater, 45177
- Clinton Memorial Hospital
-
Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
- Wright-Patterson Medical Center
-
Xenia, Ohio, Forenede Stater, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis HealthCare System
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Forenede Stater, 74146
- Tulsa Cancer Institute
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, Forenede Stater, 74104
- Oklahoma Oncology Inc
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Warren Cancer Research Foundation
-
-
Oregon
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Medical Center-Bend
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Asante Health System
-
Milwaukie, Oregon, Forenede Stater, 97222
- Providence Milwaukie Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente
-
Portland, Oregon, Forenede Stater, 97227
- Legacy Emanuel Hospital and Health Center
-
Portland, Oregon, Forenede Stater, 97213
- Western Oncology Research Consortium
-
Portland, Oregon, Forenede Stater, 97227
- Compass Oncology Rose Quarter
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Butler, Pennsylvania, Forenede Stater, 16001
- Butler Memorial Hospital
-
Darby, Pennsylvania, Forenede Stater, 19023-1291
- Mercy Fitzgerald Hospital
-
Easton, Pennsylvania, Forenede Stater, 18042
- Easton Hospital
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Hospital
-
Natrona Heights, Pennsylvania, Forenede Stater, 15065
- Alle-Kiski Medical Center
-
Norristown, Pennsylvania, Forenede Stater, 19401
- Mercy Suburban Hospital and Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19143
- Mercy Hospital of Philadelphia
-
Phoenixville, Pennsylvania, Forenede Stater, 19460
- Phoenixville Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny Cancer Center at Allegheny General Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
Upland, Pennsylvania, Forenede Stater, 19013
- Associates In Hematology Oncology PC-Upland
-
West Grove, Pennsylvania, Forenede Stater, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Cancer Center
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Hospital
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Forenede Stater, 29640
- Greenville Health System Cancer Institute-Easley
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Greenville Health System Cancer Institute-Andrews
-
Greenville, South Carolina, Forenede Stater, 29605
- Greenville Health System Cancer Institute-Faris
-
Greenville, South Carolina, Forenede Stater, 29605
- Greenville Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29615
- Greenville Health System Cancer Institute-Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Greenville Health System Cancer Institute-Butternut
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Greer, South Carolina, Forenede Stater, 29650
- Greenville Health System Cancer Institute-Greer
-
Lancaster, South Carolina, Forenede Stater, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, Forenede Stater, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, Forenede Stater, 29672
- Greenville Health System Cancer Institute-Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
Spartanburg, South Carolina, Forenede Stater, 29307
- Greenville Health System Cancer Institute-Spartanburg
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Upstate Carolina CCOP
-
-
South Dakota
-
Rapid City, South Dakota, Forenede Stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center-Oncology Clinic
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Medical X-Ray Center
-
-
Tennessee
-
Knoxville, Tennessee, Forenede Stater, 37916
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, Forenede Stater, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, Forenede Stater, 38104
- Veterans Affairs Medical Center - Memphis
-
Memphis, Tennessee, Forenede Stater, 38163
- University of Tennessee Health Science Center
-
Nashville, Tennessee, Forenede Stater, 37208
- Meharry Medical College
-
-
Texas
-
Austin, Texas, Forenede Stater, 78705
- Texas Oncology-Austin Midtown
-
Austin, Texas, Forenede Stater, 78731
- Texas Oncology - Central Austin Cancer Center
-
Austin, Texas, Forenede Stater, 78745
- Texas Oncology - South Austin Cancer Center
-
Austin, Texas, Forenede Stater, 78758
- Texas Oncology-Austin North
-
Cedar Park, Texas, Forenede Stater, 78613
- Texas Oncology-Cedar Park
-
Galveston, Texas, Forenede Stater, 77555-0565
- University of Texas Medical Branch at Galveston
-
Houston, Texas, Forenede Stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
Houston, Texas, Forenede Stater, 77030
- Methodist Hospital
-
Houston, Texas, Forenede Stater, 77030
- Saint Luke's Episcopal Hospital
-
Houston, Texas, Forenede Stater, 77030
- Veterans Administration Medical Center
-
Lubbock, Texas, Forenede Stater, 79430
- Texas Tech University Health Sciences Center
-
Round Rock, Texas, Forenede Stater, 78665
- Texas Oncology-Seton Williamson
-
Round Rock, Texas, Forenede Stater, 78681
- Texas Oncology - Round Rock Cancer Center
-
San Antonio, Texas, Forenede Stater, 78229
- University Hospital
-
San Antonio, Texas, Forenede Stater, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78209
- Audie L Murphy Veterans Affairs Hospital
-
San Marcos, Texas, Forenede Stater, 78666
- Texas Oncology- San Marcos
-
Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
-
-
Utah
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Bennington, Vermont, Forenede Stater, 05201
- Southwestern Vermont Medical Center
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia
-
Charlottesville, Virginia, Forenede Stater, 22901
- Martha Jefferson Hospital
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Fredericksburg Oncology Inc
-
-
Washington
-
Anacortes, Washington, Forenede Stater, 98221
- Cancer Care Center at Island Hospital
-
Auburn, Washington, Forenede Stater, 98001
- Auburn Regional Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Hospital Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Medical Center-Edmonds
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Kirkland, Washington, Forenede Stater, 98034
- Seattle Cancer Care Alliance at EvergreenHealth
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Valley Hospital
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, Forenede Stater, 98507
- Capital Medical Center
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center
-
Seattle, Washington, Forenede Stater, 98109
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
-
Seattle, Washington, Forenede Stater, 98104
- Harborview Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative-Seattle
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98122
- The Polyclinic
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98101
- Virginia Mason CCOP
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative of Puget Sound Oncology Consortium
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- United General Hospital
-
Spokane, Washington, Forenede Stater, 99218
- Evergreen Hematology and Oncology PS
-
Spokane, Washington, Forenede Stater, 99202
- Cancer Care Northwest - Spokane South
-
Spokane, Washington, Forenede Stater, 99220
- Rockwood Clinic
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Saint Joseph Medical Center
-
Tacoma, Washington, Forenede Stater, 98415
- MultiCare Health System
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest CCOP
-
Vancouver, Washington, Forenede Stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, Forenede Stater, 98684
- Compass Oncology Vancouver
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Wenatchee, Washington, Forenede Stater, 98801
- Wenatchee Valley Hospital and Clinics
-
-
West Virginia
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Princeton, West Virginia, Forenede Stater, 24740
- Princeton Community Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54911
- Fox Valley Hematology and Oncology
-
Elkhorn, Wisconsin, Forenede Stater, 53121
- Aurora Cancer Care-Southern Lakes
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54311-6519
- Aurora BayCare Medical Center
-
Janesville, Wisconsin, Forenede Stater, 53547
- Mercy Health System
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Bay Area Medical Center
-
Marinette, Wisconsin, Forenede Stater, 54143
- Vince Lombardi Cancer Clinic-Marinette
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Green Bay Oncology - Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53405
- Wheaton Franciscan Cancer Care - All Saints
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Saint Nicholas Hospital
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Riverview Hospital
-
-
Wyoming
-
Casper, Wyoming, Forenede Stater, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Tlalpan, Mexico, 14080
- Instituto Nacional De Cancerologia de Mexico
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- Patienter skal have histologisk eller cytologisk dokumenteret primær ikke-småcellet lungecancer (adenokarcinom, storcellet karcinom, pladecellekræft eller uspecificeret); sygdom skal være stadium IV; sygdom kan enten være nydiagnosticeret eller tilbagevendende efter tidligere operation og/eller bestråling; patienter med yderligere læsioner i en ipsilateral ikke-primær lap uden M1a eller M1b sygdom vil ikke blive anset for at have stadium IV sygdom og er ikke kvalificerede
- Patienter skal have en computertomografi (CT) eller magnetisk resonansbilleddannelse (MRI)-scanning af hjernen for at evaluere for sygdom i centralnervesystemet (CNS) inden for 42 dage før registrering; patienten må ikke have hjernemetastaser, medmindre: (1) metastaser er blevet behandlet og har været under kontrol i mindst to uger efter behandling, OG (2) patienten ikke har nogen resterende neurologisk dysfunktion uden kortikosteroider i mindst 1 dag
- Patienter kan have målbar eller ikke-målbar sygdom dokumenteret ved CT eller MR; CT'en fra en kombineret positronemissionstomografi (PET)/CT kan kun bruges til at dokumentere ikke-målbar sygdom, medmindre den er af diagnostisk kvalitet; målbar sygdom skal vurderes inden for 28 dage før registrering; pleurale effusioner, ascites og laboratorieparametre er ikke acceptable som det eneste tegn på sygdom; ikke-målbar sygdom skal vurderes inden for 42 dage før registrering; al sygdom skal vurderes og dokumenteres på Baseline Tumor Assessment Form
- Patienter skal have tumorvæv tilgængeligt til indsendelse, der er tilstrækkeligt til EGFR FISH-testning, og skal acceptere indsendelse af disse prøver; patienter skal også acceptere indsendelse af prøver til andre translationelle medicinske undersøgelser; patient skal tilbydes deltagelse i bankvirksomhed til fremtidig forskning
- Patienter må ikke have modtaget forudgående kemoterapi for ikke-småcellet lungecancer i nogen fase; patienter må ikke have modtaget tidligere platinbaseret kemoterapi til noget formål; patienten må ikke have modtaget cetuximab, gefitinib, erlotinib eller andre forsøgsmidler, der er målrettet mod EGFR-vejen; patienter må ikke til noget formål tidligere have modtaget bevacizumab eller andre vaskulære endotelvækstfaktorer (VEGF)-relaterede midler; patienter må ikke til noget formål have modtaget forudgående kimæriseret eller murin monoklonalt antistofbehandling eller have dokumenteret tilstedeværelse af humane anti-muse-antistoffer (HAMA)
- Forudgående stråling er tilladt; dog skal patienter være kommet sig over alle associerede toksiciteter på registreringstidspunktet; for at kunne kvalificeres som målbar, skal målbar sygdom være uden for det tidligere strålefelt eller være udviklet
Tiden fra kirurgiske eller biopsiprocedurer afhænger af, om det er planlagt, at patienten skal modtage bevacizumab
- For patienter, der er bevacizumab-egnede OG bevacizumab er planlagt: Der skal være gået mindst 28 dage siden større operation (dvs. thorakotomi eller videoassisteret thorakoskopisk kirurgi [VATS] resektion af lungekræft, åben pleurabiopsi eller en anden større kirurgisk procedure såsom abdominal kirurgi) eller betydelig traumatisk skade; patienter skal være kommet sig over alle associerede toksiciteter på registreringstidspunktet; der må ikke være nogen forventning om behov for større kirurgiske indgreb under protokolbehandling; patienter må ikke have haft en kernebiopsi, mediastinoskopi, pleurodesis, VATS pleural biopsi eller VATS perikardievindue inden for 14 dage før registrering; patienter må ikke have fået implanteret en perkutan finnålsaspiration (FNA), thoracentese eller central venøs adgangsanordning inden for 7 dage før registrering; for andre kirurgiske indgreb, der ikke er anført her, bedes du kontakte studiekoordinatorerne
- For patienter, som er uhensigtsmæssige med bevacizumab, eller der ikke er planlagt bevacizumab: Der skal være gået mindst 28 dage siden større operation (dvs. torakotomi eller VATS-resektion af lungekræft, åben pleurabiopsi eller en anden større kirurgisk procedure såsom abdominal kirurgi) eller betydelig traumatisk skade; patienter skal være kommet sig over alle associerede toksiciteter på registreringstidspunktet; der må ikke være nogen forventning om behov for større kirurgiske indgreb under protokolbehandling; patienter må ikke have haft en kernebiopsi, mediastinoskopi, pleurodesis, VATS pleural biopsi eller VATS perikardievindue inden for 7 dage før registrering; patienter må ikke have haft en perkutan finnålsaspiration (FNA) eller thoracentese inden for 1 dag før registrering; patienter kan have fået placeret en central venøs adgangsanordning på et hvilket som helst tidspunkt før registreringen; for andre kirurgiske indgreb, der ikke er anført her, bedes du kontakte studiekoordinatorerne
- Absolut neutrofiltal (ANC) >= 1.500/mcl
- Blodpladetal >= 100.000/mcl
- Hæmoglobin >= 9 g/dL
- Serumkreatinin =< institutionel øvre normalgrænse (IULN) OG beregnet eller målt kreatininclearance >= 50 cc/min ved hjælp af følgende Cockroft-Gault-formel
- For patienter, der skal modtage bevacizumab, skal urinprotein screenes ved urinanalyse for urinproteinkreatinin (UPC)-forhold; for UPC-forhold > 0,5 skal 24-timers urinprotein opnås, og niveauet skal være < 1.000 mg for patientindskrivning; urinproteinet, der anvendes til at beregne UPC-forholdet, skal være opnået inden for 14 dage før registrering; UPC eller 24-timers protein er ikke påkrævet for patienter, der ikke vil modtage bevacizumab Bemærk: UPC-forholdet af pleturin er et estimat af 24-timers urinproteinudskillelse - et UPC-forhold på 1 svarer nogenlunde til et 24-timers urinprotein på 1 gm
- Serumbilirubin =< 2 gange IULN (for patienter med levermetastaser skal bilirubin være =< 5 X IULN)
- Serumglutamin-oxaloeddikesyretransaminase (SGOT) ELLER serumglutamatpyruvattransaminase (SGPT) =< 2 gange IULN (for patienter med levermetastaser skal enten SGOT eller SGPT være =< 5 X IULN)
- Zubrod præstationsstatus 0-1
- Patienter må ikke have >= grad 2 symptomatisk neuropati-sensorisk (National Cancer Institute [NCI] Common Terminology Criteria version 3.0)
- Patienter må ikke have dokumenteret tegn på akut hepatitis eller have en aktiv eller ukontrolleret infektion
- Patienter må ikke have følgende: anamnese (inden for de seneste 6 måneder) med cerebrovaskulær ulykke (CVA), myokardieinfarkt eller ustabil angina; eller på registreringstidspunktet, ukontrolleret hypertension, New York Heart Association grad 2 eller større kongestiv hjerteinsufficiens, alvorlig hjertearytmi, der kræver medicin, eller klinisk signifikant perifer vaskulær sygdom
- Patienter må ikke have nogen kendt overfølsomhed over for ovariecelleprodukter fra kinesisk hamster eller andre rekombinante humane antistoffer (eksempler inkluderer trastuzumab [Herceptin] og epoetin alfa)
- Patienter skal være villige til at oplyse tidligere rygehistorie
Ingen anden tidligere malignitet er tilladt undtagen for nogen af følgende:
- Tilstrækkeligt behandlet basalcelle- eller pladecellehudkræft
- In situ livmoderhalskræft
- Tilstrækkeligt behandlet kræft i stadium I eller II, hvor patienten i øjeblikket er i fuldstændig remission
- Enhver anden kræftsygdom, hvor patienten har været sygdomsfri i 5 år
- Patienter må ikke være gravide eller ammende; kvinder/mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode; en kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder; ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral oophorektomi eller bilateral tubal ligering; men hvis en tidligere cølibatpatient på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsforanstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
- Patienter eller deres juridisk autoriserede repræsentant skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer
- Som en del af registreringsprocessen for Oncology Patient Enrollment Network (OPEN) oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionsbedømmelsesudvalgets godkendelse af denne undersøgelse er blevet indtastet i systemet
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: Arm I (kemo +/- bevacizumab)
Patienterne får paclitaxel IV over 3 timer og carboplatin IV over 30 minutter med eller uden bevacizumab IV over 30-90 minutter på dag 1.
Behandlingen gentages hver 21. dag i op til 6 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afslutning af 6 kure kan patienter, der får bevacizumab, fortsætte med at modtage bevacizumab (som ovenfor) i fravær af sygdomsprogression eller uacceptabel toksicitet.
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Korrelative undersøgelser
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
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Eksperimentel: Arm II (kemo, cetuximab, +/- bevacizumab)
Patienterne får paclitaxel og carboplatin med eller uden bevacizumab som i arm I. Patienterne får også cetuximab IV over 1-2 timer på dag 1, 8 og 15.
Behandlingen gentages hver 21. dag i op til 6 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afslutning af 6 kure kan patienter fortsætte med at modtage cetuximab med eller uden bevacizumab (som ovenfor) i fravær af sygdomsprogression eller uacceptabel toksicitet.
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Korrelative undersøgelser
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Samlet overlevelse (OS) i hele undersøgelsespopulationen
Tidsramme: Patienterne vil blive fulgt hver 3. uge under protokolbehandling. Efter endt protokolbehandling vil patienterne blive fulgt hver 6. måned indtil døden eller op til 3 år
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Fra dato for randomisering til dato for død på grund af enhver årsag.
Patienter, der sidst vides at være i live, censureres på datoen for sidste kontakt.
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Patienterne vil blive fulgt hver 3. uge under protokolbehandling. Efter endt protokolbehandling vil patienterne blive fulgt hver 6. måned indtil døden eller op til 3 år
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Progressionsfri overlevelse (PFS) af EGFR FISH-positive patienter ved institutionel gennemgang
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Fra datoen for randomisering til datoen for første dokumentation for progression eller symptomatisk forværring, eller død på grund af en hvilken som helst årsag, alt efter hvad der kommer først af Respons Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), som vurderet af den behandlende investigator. Patienter sidst kendte at være i live og progressionsfri censureres på datoen for sidste kontakt.
Progression defineres ved hjælp af RECIST 1.1, som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner.
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Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Responsrate (bekræftet plus ubekræftede, fuldstændige og delvise svar) i undergruppen af patienter med målbar sygdom hos EGFR FISH-positive patienter
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR eller CT: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR
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Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Responsrate (bekræftet plus ubekræftede, fuldstændige og delvise svar) i undergruppen af patienter med målbar sygdom i hele undersøgelsespopulationen
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR eller CT: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR.
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Sygdomsvurdering vil blive gentaget hver 6. uge i de første 9 måneder og hver 3. måned derefter, indtil sygdomsprogression.
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Antal patienter med gr 3 til 5 uønskede hændelser, der er relateret til undersøgelsesmedicin
Tidsramme: Toksicitetsvurdering blev evalueret hver 3. uge, mens en protokolbehandling blev behandlet. Kemo og cetuximab behandles i 6 cyklusser (1 cyklus = 3 uger), og Bevacizumab behandles indtil progression eller uacceptabel toksicitet.
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Uønskede hændelser (AE'er) rapporteres af CTCAE version 4.0.
Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret.
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Toksicitetsvurdering blev evalueret hver 3. uge, mens en protokolbehandling blev behandlet. Kemo og cetuximab behandles i 6 cyklusser (1 cyklus = 3 uger), og Bevacizumab behandles indtil progression eller uacceptabel toksicitet.
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Samlet overlevelse (OS) af EGFR FISH-positive patienter
Tidsramme: Patienterne vil blive fulgt hver 3. uge under protokolbehandling. Efter endt protokolbehandling vil patienterne blive fulgt hver 6. måned indtil døden eller op til 3 år
|
Fra dato for randomisering til dato for død på grund af enhver årsag.
Patienter, der sidst vides at være i live, censureres på datoen for sidste kontakt.
|
Patienterne vil blive fulgt hver 3. uge under protokolbehandling. Efter endt protokolbehandling vil patienterne blive fulgt hver 6. måned indtil døden eller op til 3 år
|
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Progressionsfri overlevelse (PFS) af EGFR FISH-positive patienter ved centraliseret gennemgang
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
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Fra datoen for randomisering til datoen for første dokumentation for progression eller symptomatisk forværring, eller død på grund af en hvilken som helst årsag, alt efter hvad der kommer først af Respons Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), som vurderet af den behandlende investigator. Patienter sidst kendte at være i live og progressionsfri censureres på datoen for sidste kontakt.
Progression defineres ved hjælp af RECIST 1.1 som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner.
|
Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
|
|
Progressionsfri overlevelse (PFS) af hele undersøgelsespopulationen ved institutionel gennemgang
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
|
Fra datoen for randomisering til datoen for første dokumentation for progression eller symptomatisk forværring, eller død på grund af en hvilken som helst årsag, alt efter hvad der kommer først af Respons Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), som vurderet af den behandlende investigator. Patienter sidst kendte at være i live og progressionsfri censureres på datoen for sidste kontakt.
Progression defineres ved hjælp af RECIST 1.1 som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner.
|
Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
|
|
Progressionsfri overlevelse (PFS) af hele undersøgelsespopulationen ved centraliseret gennemgang
Tidsramme: Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
|
Fra datoen for randomisering til datoen for første dokumentation for progression eller symptomatisk forværring, eller død på grund af en hvilken som helst årsag, alt efter hvad der kommer først af Respons Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), som vurderet af den behandlende investigator. Patienter sidst kendte at være i live og progressionsfri censureres på datoen for sidste kontakt.
Progression defineres ved hjælp af RECIST 1.1 som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner.
|
Sygdomsvurdering vil blive gentaget hver 6. uge indtil sygdomsprogression under behandling. Efter afbrudt behandling kan hyppigheden af sygdomsvurdering reduceres til hver 3. måned indtil sygdomsprogression.
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Roy Herbst, SWOG Cancer Research Network
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Hirsch FR, Redman MW, Moon J, Agustoni F, Herbst RS, Semrad TJ, Varella-Garcia M, Rivard CJ, Kelly K, Gandara DR, Mack PC. EGFR High Copy Number Together With High EGFR Protein Expression Predicts Improved Outcome for Cetuximab-based Therapy in Squamous Cell Lung Cancer: Analysis From SWOG S0819, a Phase III Trial of Chemotherapy With or Without Cetuximab in Advanced NSCLC. Clin Lung Cancer. 2022 Jan;23(1):60-71. doi: 10.1016/j.cllc.2021.10.002. Epub 2021 Oct 10.
- Herbst RS, Redman MW, Kim ES, Semrad TJ, Bazhenova L, Masters G, Oettel K, Guaglianone P, Reynolds C, Karnad A, Arnold SM, Varella-Garcia M, Moon J, Mack PC, Blanke CD, Hirsch FR, Kelly K, Gandara DR. Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study. Lancet Oncol. 2018 Jan;19(1):101-114. doi: 10.1016/S1470-2045(17)30694-0. Epub 2017 Nov 20.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
15. juli 2009
Primær færdiggørelse (Faktiske)
31. august 2017
Studieafslutning (Faktiske)
8. februar 2022
Datoer for studieregistrering
Først indsendt
24. juli 2009
Først indsendt, der opfyldte QC-kriterier
24. juli 2009
Først opslået (Skøn)
27. juli 2009
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
23. maj 2023
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
19. maj 2023
Sidst verificeret
1. maj 2023
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Patologiske processer
- Luftvejssygdomme
- Neoplasmer efter histologisk type
- Neoplasmer
- Lungesygdomme
- Neoplasmer efter sted
- Neoplasmer, kirtel og epitel
- Sygdomsegenskaber
- Neoplasmer i luftvejene
- Thoracale neoplasmer
- Lungeneoplasmer
- Karcinom
- Tilbagevenden
- Adenocarcinom
- Adenocarcinom i lunge
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, fytogene
- Angiogenese-hæmmere
- Angiogenesemodulerende midler
- Vækststoffer
- Væksthæmmere
- Carboplatin
- Paclitaxel
- Antistoffer
- Immunoglobuliner
- Bevacizumab
- Albumin-bundet Paclitaxel
- Antistoffer, monoklonale
- Antineoplastiske midler, immunologiske
- Cetuximab
- Immunoglobulin G
- Endotelvækstfaktorer
Andre undersøgelses-id-numre
- S0819 (Anden identifikator: CTEP)
- U10CA032102 (U.S. NIH-bevilling/kontrakt)
- U10CA180888 (U.S. NIH-bevilling/kontrakt)
- NCI-2009-01664 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- CDR0000649817
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .