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Kardiovaskulær risikoreduktionsundersøgelse (reduktion i tilbagevendende større CV-sygdomsbegivenheder) (CANTOS)

10. januar 2020 opdateret af: Novartis Pharmaceuticals

Et randomiseret, dobbeltblindt, placebokontrolleret, hændelsesdrevet forsøg med kvartalsvis subkutan canakinumab til forebyggelse af tilbagevendende kardiovaskulære hændelser blandt stabile post-myokardieinfarktpatienter med forhøjet hsCRP

Hovedundersøgelse (CACZ885M2301): Formålet med den pivotale fase af dette forsøg var at teste hypotesen om, at canakinumab-behandling af patienter med myokardieinfarkt (MI) mindst en måned før studiestart og forhøjet hsCRP kunne forhindre tilbagevendende kardiovaskulære hændelser.

Formålet med forlængelsesfasen af hovedstudiet er at indsamle yderligere langsigtede sikkerhedsdata om fortsat eksponering for canakinumab hos patienter, der deltog i den pivotale fase.

Delstudie 1 (CACZ885M2301S1): Formålet med dette delstudie var at evaluere effekten af kvartalsvis subkutan canakinumab-behandling i 24 måneder sammenlignet med placebo på carotis plaque-byrden målt ved integreret vaskulær MRI hos patienter inkluderet i CACZ885M2301-studiet (CANTOS1). ).

Delstudie 2 (CACZ885M2301S2): Formålet med denne CANTOS-delundersøgelse var at bestemme, om canakinumab sammenlignet med placebo, ud over standardbehandling, kunne øge insulinsekretionen hos patienter med type 2-diabetes, der deltog i CANTOS-hovedstudiet. insulinfølsomhed.

Studieoversigt

Status

Afsluttet

Betingelser

Åreforkalkning

Intervention / Behandling

Detaljeret beskrivelse

Delstudie 1 og 2 blev afsluttet før dataindsamling fra forsøgspersoner. Der er dog et igangværende forlængelsesforsøg, hvor patienter modtager et åbent lægemiddelmærke.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

10066

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Caba, Argentina, C1119ACN
    - Novartis Investigative Site
  - Cordoba, Argentina, X5022CPU
    - Novartis Investigative Site
  - Cordoba, Argentina, X5003DCP
    - Novartis Investigative Site
  - Cordoba, Argentina, X5009BSN
    - Novartis Investigative Site
  - Cordoba, Argentina, X5006CBI
    - Novartis Investigative Site
  - Cordoba, Argentina, X5000AAW
    - Novartis Investigative Site
  - Cordoba, Argentina, X5003DCE
    - Novartis Investigative Site
  - Cordoba, Argentina, 5000
    - Novartis Investigative Site
  - Cordoba, Argentina, X5000AAX
    - Novartis Investigative Site
  - Cordoba, Argentina, X5000AAJ
    - Novartis Investigative Site
  - Cordoba, Argentina, X5000JJS
    - Novartis Investigative Site
  - Cordoba, Argentina, X5000EPU
    - Novartis Investigative Site
  - Cordoba, Argentina, X5220XAO
    - Novartis Investigative Site
  - Corrientes, Argentina, W3400
    - Novartis Investigative Site
  - Corrientes, Argentina, W3400CLH
    - Novartis Investigative Site
  - Corrientes, Argentina, W3410AVV
    - Novartis Investigative Site
  - Corrientes, Argentina, W3400CBI
    - Novartis Investigative Site
  - Formosa, Argentina, P3600
    - Novartis Investigative Site
  - Formosa, Argentina, P3634XAR
    - Novartis Investigative Site
  - Salta, Argentina, 4400
    - Novartis Investigative Site
  - San Luis, Argentina, D5702JRS
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000EPV
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000FWO
    - Novartis Investigative Site
  - Santa Fe, Argentina, S3000EOZ
    - Novartis Investigative Site
  - Santiago del Estero, Argentina, G4200AQK
    - Novartis Investigative Site
  - Tucuman, Argentina, T4000HXU
    - Novartis Investigative Site
- Buenos Aires
  - Bahía Blanca, Buenos Aires, Argentina, B8000AAT
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1056ABJ
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1440AAD
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1221ADC
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1425AGC
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, 1428
    - Novartis Investigative Site
  - Caba, Buenos Aires, Argentina, C1425BWO
    - Novartis Investigative Site
  - Mar del Plata, Buenos Aires, Argentina, 7600
    - Novartis Investigative Site
  - Mar del Plata, Buenos Aires, Argentina, B7600
    - Novartis Investigative Site
  - Quilmes, Buenos Aires, Argentina, B1878GEG
    - Novartis Investigative Site
  - Quilmes, Buenos Aires, Argentina, B1878DVB
    - Novartis Investigative Site
  - Ramos Mejia, Buenos Aires, Argentina, B1704ETD
    - Novartis Investigative Site
  - San Isidro, Buenos Aires, Argentina, B1642DCD
    - Novartis Investigative Site
  - San Nicolas, Buenos Aires, Argentina, B2900DMH
    - Novartis Investigative Site
  - Zarate, Buenos Aires, Argentina, 2800
    - Novartis Investigative Site
- Capital Federal
  - Caba, Capital Federal, Argentina, C1430CKE
    - Novartis Investigative Site
  - Caba, Capital Federal, Argentina, C1179AAB
    - Novartis Investigative Site
- Jujuy
  - San Salvador de Jujuy, Jujuy, Argentina, Y4600ABF
    - Novartis Investigative Site
- Misiones
  - Posadas, Misiones, Argentina, N3300AHX
    - Novartis Investigative Site
- Rio Negro
  - Cipolletti, Rio Negro, Argentina, 8324
    - Novartis Investigative Site
- San Miguel De Tucuman
  - Tucuman, San Miguel De Tucuman, Argentina, T4000ICL
    - Novartis Investigative Site
- Santa Fe
  - Rosario, Santa Fe, Argentina, S2000DSV
    - Novartis Investigative Site
  - Rosario, Santa Fe, Argentina, S2000
    - Novartis Investigative Site
  - Rosario, Santa Fe, Argentina, S2000CXP
    - Novartis Investigative Site
- Tucuman
  - San Miguel de Tucuman, Tucuman, Argentina, T4000EBR
    - Novartis Investigative Site
  - San Miguel de Tucuman, Tucuman, Argentina, T4000IFL
    - Novartis Investigative Site
  - San Miguel de Tucuman, Tucuman, Argentina, T4000IIH
    - Novartis Investigative Site
Australien
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australien, 2606
    - Novartis Investigative Site
- New South Wales
  - Gosford, New South Wales, Australien, 2250
    - Novartis Investigative Site
  - Kogarah, New South Wales, Australien, 2217
    - Novartis Investigative Site
  - Liverpool, New South Wales, Australien, 2170
    - Novartis Investigative Site
- Queensland
  - Milton, Queensland, Australien, 4064
    - Novartis Investigative Site
  - Southport, Queensland, Australien, 4215
    - Novartis Investigative Site
- Tasmania
  - Hobart, Tasmania, Australien, 7000
    - Novartis Investigative Site
- Victoria
  - Bundoora, Victoria, Australien, 3083
    - Novartis Investigative Site
  - Geelong, Victoria, Australien, 3220
    - Novartis Investigative Site
- Western Australia
  - Bateman, Western Australia, Australien, 6150
    - Novartis Investigative Site
  - Joondalup, Western Australia, Australien, 6027
    - Novartis Investigative Site
  - Perth, Western Australia, Australien, 6000
    - Novartis Investigative Site
Belgien
- - Aalst, Belgien, 9300
    - Novartis Investigative Site
  - Bonheiden, Belgien, 2820
    - Novartis Investigative Site
  - Brasschaat, Belgien, 2930
    - Novartis Investigative Site
  - Brussel, Belgien, 1000
    - Novartis Investigative Site
  - De Pinte, Belgien, 9840
    - Novartis Investigative Site
  - Genk, Belgien, 3600
    - Novartis Investigative Site
  - Gent, Belgien, 9000
    - Novartis Investigative Site
  - Hasselt, Belgien, 3500
    - Novartis Investigative Site
  - Huy, Belgien, 4500
    - Novartis Investigative Site
  - Leuven, Belgien, 3000
    - Novartis Investigative Site
  - Mechelen, Belgien, 2800
    - Novartis Investigative Site
  - Ottignies, Belgien, 1340
    - Novartis Investigative Site
  - Tienen, Belgien, 3300
    - Novartis Investigative Site
Brasilien
- BA
  - Salvador, BA, Brasilien, 40050-410
    - Novartis Investigative Site
  - Salvador, BA, Brasilien, 40140-110
    - Novartis Investigative Site
- CE
  - Fortaleza, CE, Brasilien, 60430 370
    - Novartis Investigative Site
- DF
  - Brasilia, DF, Brasilien, 70390-903
    - Novartis Investigative Site
  - Brasilia, DF, Brasilien, 70658-700
    - Novartis Investigative Site
- GO
  - Goiania, GO, Brasilien, 74223-130
    - Novartis Investigative Site
  - Goiania, GO, Brasilien, 74605-020
    - Novartis Investigative Site
- MG
  - Belo Horizonte, MG, Brasilien, 30150-221
    - Novartis Investigative Site
  - Belo Horizonte, MG, Brasilien, 30130-060
    - Novartis Investigative Site
  - Uberlandia, MG, Brasilien, 38405-320
    - Novartis Investigative Site
- MS
  - Campo Grande, MS, Brasilien, 79080-190
    - Novartis Investigative Site
- Minas Gerais
  - Uberlandia, Minas Gerais, Brasilien, 38411 186
    - Novartis Investigative Site
- PA
  - Belem, PA, Brasilien, 66087-660
    - Novartis Investigative Site
- PE
  - Recife, PE, Brasilien, 52051-380
    - Novartis Investigative Site
- PR
  - Curitiba, PR, Brasilien, 80730-150
    - Novartis Investigative Site
- RS
  - Passo Fundo, RS, Brasilien, 99010-080
    - Novartis Investigative Site
  - Pelotas, RS, Brasilien, 96015-290
    - Novartis Investigative Site
  - Porto Alegre, RS, Brasilien, 90620 001
    - Novartis Investigative Site
  - Porto Alegre, RS, Brasilien, 91350 200
    - Novartis Investigative Site
  - Porto Alegre, RS, Brasilien, 90880-480
    - Novartis Investigative Site
  - Porto Alegre, RS, Brasilien, 90560-030
    - Novartis Investigative Site
- Rio Grande Do Sul
  - Porto Alegre, Rio Grande Do Sul, Brasilien, 90610-000
    - Novartis Investigative Site
- SC
  - Blumenau, SC, Brasilien, 89020 430
    - Novartis Investigative Site
- SP
  - Campinas, SP, Brasilien, 13060 080
    - Novartis Investigative Site
  - Campinas, SP, Brasilien, 13010-001
    - Novartis Investigative Site
  - Campinas, SP, Brasilien, 13020-431
    - Novartis Investigative Site
  - Santo Andre, SP, Brasilien, 09190-615
    - Novartis Investigative Site
  - Sao Jose do Rio Preto, SP, Brasilien, 15090 000
    - Novartis Investigative Site
  - Sao Paulo, SP, Brasilien, 05403-000
    - Novartis Investigative Site
  - Sao Paulo, SP, Brasilien, 01323 000
    - Novartis Investigative Site
  - Sao Paulo, SP, Brasilien, 04023-900
    - Novartis Investigative Site
  - São Paulo, SP, Brasilien, 05508-000
    - Novartis Investigative Site
  - Tatuí, SP, Brasilien, 18270-170
    - Novartis Investigative Site
  - Votuporanga, SP, Brasilien, 15500 003
    - Novartis Investigative Site
Bulgarien
- - Pazardzhik, Bulgarien, 4400
    - Novartis Investigative Site
  - Pleven, Bulgarien, 5800
    - Novartis Investigative Site
  - Plovdiv, Bulgarien, 4000
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1527
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1309
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1431
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1202
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1233
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1606
    - Novartis Investigative Site
  - Sofia, Bulgarien, 1000
    - Novartis Investigative Site
Canada
- - Quebec, Canada, G1V 4G2
    - Novartis Investigative Site
  - Quebec, Canada, G1G 3Y8
    - Novartis Investigative Site
  - Quebec, Canada, G3K 2P8
    - Novartis Investigative Site
- British Columbia
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Novartis Investigative Site
  - Surrey, British Columbia, Canada, V3V 0C6
    - Novartis Investigative Site
  - Victoria, British Columbia, Canada, V8R4R2
    - Novartis Investigative Site
- Manitoba
  - Winnipeg, Manitoba, Canada, R2V 4W3
    - Novartis Investigative Site
- Newfoundland and Labrador
  - Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7
    - Novartis Investigative Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Novartis Investigative Site
- Ontario
  - Cambridge, Ontario, Canada, N1R 6V6
    - Novartis Investigative Site
  - Etobicoke, Ontario, Canada, M9V 4B4
    - Novartis Investigative Site
  - Hamilton, Ontario, Canada, L8L 2X2
    - Novartis Investigative Site
  - Kitchener, Ontario, Canada, N2M 5N4
    - Novartis Investigative Site
  - Mississauga, Ontario, Canada, L5K 2L3
    - Novartis Investigative Site
  - Newmarket, Ontario, Canada, L3Y 8C3
    - Novartis Investigative Site
  - Newmarket, Ontario, Canada, L3Y 2P7
    - Novartis Investigative Site
  - Ottawa, Ontario, Canada, K1Y 4W7
    - Novartis Investigative Site
  - Peterborough, Ontario, Canada, K9J 0B2
    - Novartis Investigative Site
  - Scarborough, Ontario, Canada, M1P 2V5
    - Novartis Investigative Site
  - Toronto, Ontario, Canada, M5B 1N9
    - Novartis Investigative Site
  - Toronto, Ontario, Canada, M9W 4L6
    - Novartis Investigative Site
- Quebec
  - Drummondville, Quebec, Canada, J2B 7T1
    - Novartis Investigative Site
  - Gatineau, Quebec, Canada, J8Y 6S8
    - Novartis Investigative Site
  - Granby, Quebec, Canada, J2G 1T7
    - Novartis Investigative Site
  - Joliette, Quebec, Canada, J6E 6J2
    - Novartis Investigative Site
  - Lachine, Quebec, Canada, H8S 2E4
    - Novartis Investigative Site
  - Laval, Quebec, Canada, H7M 3L9
    - Novartis Investigative Site
  - Levis, Quebec, Canada, G6V 4Z5
    - Novartis Investigative Site
  - Longueuil, Quebec, Canada, J4M 2X1
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H3G 1A4
    - Novartis Investigative Site
  - Montreal, Quebec, Canada, H4J 1C5
    - Novartis Investigative Site
  - Sainte Foy, Quebec, Canada, G1V 4G5
    - Novartis Investigative Site
  - Sherbrooke, Quebec, Canada, J1G-2E8
    - Novartis Investigative Site
  - St-Jean-sur-Richelieu, Quebec, Canada, J3A 1J2
    - Novartis Investigative Site
  - Ste-Foy, Quebec, Canada, G1W 4R4
    - Novartis Investigative Site
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Novartis Investigative Site
  - Thetford Mines, Quebec, Canada, G6G 2V4
    - Novartis Investigative Site
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7H 5M3
    - Novartis Investigative Site
Colombia
- - Armenia, Colombia
    - Novartis Investigative Site
  - Baranquilla, Colombia
    - Novartis Investigative Site
  - Barranquilla, Colombia
    - Novartis Investigative Site
  - Barranquilla, Colombia, 080020
    - Novartis Investigative Site
  - Bogota, Colombia
    - Novartis Investigative Site
  - Bogotá, Colombia
    - Novartis Investigative Site
  - Cali, Colombia
    - Novartis Investigative Site
  - Cartegena, Colombia
    - Novartis Investigative Site
  - Florida Blanca, Colombia
    - Novartis Investigative Site
- Atlantico
  - Baranquilla, Atlantico, Colombia
    - Novartis Investigative Site
  - Barranquilla, Atlantico, Colombia
    - Novartis Investigative Site
- Bolivar
  - Cartagena, Bolivar, Colombia
    - Novartis Investigative Site
- Caldas
  - Manizales, Caldas, Colombia, 1700
    - Novartis Investigative Site
- Santander
  - Bucaramanga, Santander, Colombia
    - Novartis Investigative Site
  - Floridablanca, Santander, Colombia, 57-7
    - Novartis Investigative Site
Den Russiske Føderation
- - Chelyabinsk, Den Russiske Føderation, 454047
    - Novartis Investigative Site
  - Chelyabinsk, Den Russiske Føderation, 454048
    - Novartis Investigative Site
  - Chelyabinsk, Den Russiske Føderation, 454000
    - Novartis Investigative Site
  - Ekaterinburg, Den Russiske Føderation, 620028
    - Novartis Investigative Site
  - Ekaterinburg, Den Russiske Føderation, 620102
    - Novartis Investigative Site
  - Ekaterinburg, Den Russiske Føderation, 620137
    - Novartis Investigative Site
  - Izhevsk, Den Russiske Føderation, 426063
    - Novartis Investigative Site
  - Kazan, Den Russiske Føderation, 420012
    - Novartis Investigative Site
  - Kemerovo, Den Russiske Føderation, 650029
    - Novartis Investigative Site
  - Kirov, Den Russiske Føderation, 610035
    - Novartis Investigative Site
  - Kirov, Den Russiske Føderation, 610027
    - Novartis Investigative Site
  - Krasnodar, Den Russiske Føderation, 350086
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 125284
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 117198
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 127018
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 127473
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 117556
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 119881
    - Novartis Investigative Site
  - Moscow, Den Russiske Føderation, 111539
    - Novartis Investigative Site
  - Novosibirsk, Den Russiske Føderation, 630087
    - Novartis Investigative Site
  - Penza, Den Russiske Føderation, 440067
    - Novartis Investigative Site
  - Perm, Den Russiske Føderation, 614097
    - Novartis Investigative Site
  - Perm, Den Russiske Føderation, 614107
    - Novartis Investigative Site
  - Petrozavodsk, Den Russiske Føderation, 185019
    - Novartis Investigative Site
  - Ryazan, Den Russiske Føderation, 390026
    - Novartis Investigative Site
  - Saint Petersburg, Den Russiske Føderation, 197022
    - Novartis Investigative Site
  - Saint Petersburg, Den Russiske Føderation, 197341
    - Novartis Investigative Site
  - Saint Petersburg, Den Russiske Føderation, 199106
    - Novartis Investigative Site
  - Saint Petersburg, Den Russiske Føderation, 195067
    - Novartis Investigative Site
  - Saint-Petersburg, Den Russiske Føderation, 194044
    - Novartis Investigative Site
  - Saint-Petersburg, Den Russiske Føderation, 192257
    - Novartis Investigative Site
  - Samara, Den Russiske Føderation, 443070
    - Novartis Investigative Site
  - Samara, Den Russiske Føderation, 443096
    - Novartis Investigative Site
  - Saratov, Den Russiske Føderation, 410028
    - Novartis Investigative Site
  - Saratov, Den Russiske Føderation, 410012
    - Novartis Investigative Site
  - Sestroretsk, Den Russiske Føderation, 197706
    - Novartis Investigative Site
  - Smolensk, Den Russiske Føderation, 214018
    - Novartis Investigative Site
  - St-Petersburg, Den Russiske Føderation, 194295
    - Novartis Investigative Site
  - St-Petersburg, Den Russiske Føderation, 196084
    - Novartis Investigative Site
  - St. Petersburg, Den Russiske Føderation, 190013
    - Novartis Investigative Site
  - St.- Petersburg, Den Russiske Føderation, 197110
    - Novartis Investigative Site
  - St.Petersburg, Den Russiske Føderation, 193163
    - Novartis Investigative Site
  - Syktyvkar, Den Russiske Føderation, 167981
    - Novartis Investigative Site
  - Tomsk, Den Russiske Føderation, 634012
    - Novartis Investigative Site
  - Tyumen, Den Russiske Føderation, 625026
    - Novartis Investigative Site
  - Vladimir, Den Russiske Føderation, 600020
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  - Yaroslavl, Den Russiske Føderation, 150047
    - Novartis Investigative Site
  - Yekaterinburg, Den Russiske Føderation, 620109
    - Novartis Investigative Site
Det Forenede Kongerige
- - Barnet, Det Forenede Kongerige, EN5 3DJ
    - Novartis Investigative Site
  - Berkshire, Det Forenede Kongerige, RG2 0TG
    - Novartis Investigative Site
  - Birmingham, Det Forenede Kongerige, B9 5SS
    - Novartis Investigative Site
  - Birmingham, Det Forenede Kongerige, B15 2TH
    - Novartis Investigative Site
  - Birmingham, Det Forenede Kongerige, B15 2SQ
    - Novartis Investigative Site
  - Cardiff, Det Forenede Kongerige, CF14 5GJ
    - Novartis Investigative Site
  - Cheshire, Det Forenede Kongerige, CW11 1EQ
    - Novartis Investigative Site
  - Chesterfield, Det Forenede Kongerige, S40 4AA
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  - Chorley, Det Forenede Kongerige, PR7 7NA
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  - Exeter, Det Forenede Kongerige, EX2 5DW
    - Novartis Investigative Site
  - Glasgow, Det Forenede Kongerige, G51 4TF
    - Novartis Investigative Site
  - Glasgow, Det Forenede Kongerige, G20 0XA
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  - Glasgow, Det Forenede Kongerige, G20 0SP
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  - Irvine, Det Forenede Kongerige, KA12 0AY
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  - Leicester, Det Forenede Kongerige, LE3 9QP
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  - Liverpool, Det Forenede Kongerige, L22 0LG
    - Novartis Investigative Site
  - London, Det Forenede Kongerige, EC14 7BE
    - Novartis Investigative Site
  - Manchester, Det Forenede Kongerige, M15 6SX
    - Novartis Investigative Site
  - Newcastle Upon Tyne, Det Forenede Kongerige, NE7 7DN
    - Novartis Investigative Site
  - Newport, Det Forenede Kongerige, NP20 2UB
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  - Norwich, Det Forenede Kongerige, NR4 7UY
    - Novartis Investigative Site
  - Nottingham, Det Forenede Kongerige, NG5 1PB
    - Novartis Investigative Site
  - Sheffield, Det Forenede Kongerige, S5 7AU
    - Novartis Investigative Site
  - Wiltshire, Det Forenede Kongerige, SN15 2SB
    - Novartis Investigative Site
  - Worcester, Det Forenede Kongerige, WR5 1DD
    - Novartis Investigative Site
  - York, Det Forenede Kongerige, YO31 8HE
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- Hampshire
  - Basingstoke, Hampshire, Det Forenede Kongerige, RG24 9NA
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- Isle Of Wight
  - Newport, Isle Of Wight, Det Forenede Kongerige, PO30 5TG
    - Novartis Investigative Site
- Manchester
  - Salford, Manchester, Det Forenede Kongerige, M6 8HD
    - Novartis Investigative Site
- North Yorkshire
  - Whitby, North Yorkshire, Det Forenede Kongerige, Y021 1SD
    - Novartis Investigative Site
- Perthshire
  - Dundee, Perthshire, Det Forenede Kongerige, DD1 9SY
    - Novartis Investigative Site
- Somerset
  - Axbridge, Somerset, Det Forenede Kongerige, BS26 2BJ
    - Novartis Investigative Site
  - Taunton, Somerset, Det Forenede Kongerige, TA1 5DA
    - Novartis Investigative Site
- Wales
  - Cardiff, Wales, Det Forenede Kongerige, CF5 4AD
    - Novartis Investigative Site
Estland
- - Parnu, Estland, 80010
    - Novartis Investigative Site
  - Saku, Estland, 75501
    - Novartis Investigative Site
  - Tallinn, Estland, 13419
    - Novartis Investigative Site
  - Tallinn, Estland, 10138
    - Novartis Investigative Site
  - Tallinn, Estland, 13619
    - Novartis Investigative Site
  - Tallinn, Estland, 10611
    - Novartis Investigative Site
  - Tartu, Estland, 50410
    - Novartis Investigative Site
  - Viljandi County, Estland, 71024
    - Novartis Investigative Site
  - Võru, Estland, 65608
    - Novartis Investigative Site
Forenede Stater
- Alabama
  - Athens, Alabama, Forenede Stater, 35611
    - Novartis Investigative Site
  - Birmingham, Alabama, Forenede Stater, 35243
    - Novartis Investigative Site
  - Birmingham, Alabama, Forenede Stater, 35294-2041
    - Novartis Investigative Site
  - Birmingham, Alabama, Forenede Stater, 35235-3424
    - Novartis Investigative Site
  - Fairhope, Alabama, Forenede Stater, 36532
    - Novartis Investigative Site
  - Huntsville, Alabama, Forenede Stater, 35801
    - Novartis Investigative Site
  - Mobile, Alabama, Forenede Stater, 36608
    - Novartis Investigative Site
  - Mobile, Alabama, Forenede Stater, 36604
    - Novartis Investigative Site
  - Mobile, Alabama, Forenede Stater, 36617-2293
    - Novartis Investigative Site
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Novartis Investigative Site
- Arizona
  - Chandler, Arizona, Forenede Stater, 85224
    - Novartis Investigative Site
  - Glendale, Arizona, Forenede Stater, 85306
    - Novartis Investigative Site
  - Phoenix, Arizona, Forenede Stater, 85032
    - Novartis Investigative Site
  - Phoenix, Arizona, Forenede Stater, 85018
    - Novartis Investigative Site
- Arkansas
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - Novartis Investigative Site
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - Novartis Investigative Site
  - Little Rock, Arkansas, Forenede Stater, 72204
    - Novartis Investigative Site
- California
  - Beverly Hills, California, Forenede Stater, 90211
    - Novartis Investigative Site
  - Carmichael, California, Forenede Stater, 95608
    - Novartis Investigative Site
  - Escondido, California, Forenede Stater, 92025
    - Novartis Investigative Site
  - Fullerton, California, Forenede Stater, 92835
    - Novartis Investigative Site
  - Huntington Beach, California, Forenede Stater, 92647
    - Novartis Investigative Site
  - Lancaster, California, Forenede Stater, 93534
    - Novartis Investigative Site
  - Loma Linda, California, Forenede Stater, 92354
    - Novartis Investigative Site
  - Loma Linda, California, Forenede Stater, 92357
    - Novartis Investigative Site
  - Long Beach, California, Forenede Stater, 90806
    - Novartis Investigative Site
  - Los Angeles, California, Forenede Stater, 90033
    - Novartis Investigative Site
  - Los Angeles, California, Forenede Stater, 90073
    - Novartis Investigative Site
  - Los Gatos, California, Forenede Stater, 95032
    - Novartis Investigative Site
  - Mission Viejo, California, Forenede Stater, 92691
    - Novartis Investigative Site
  - Newport Beach, California, Forenede Stater, 92663
    - Novartis Investigative Site
  - Northridge, California, Forenede Stater, 91325
    - Novartis Investigative Site
  - Oceanside, California, Forenede Stater, 92056
    - Novartis Investigative Site
  - Orangevale, California, Forenede Stater, 95662
    - Novartis Investigative Site
  - Palm Springs, California, Forenede Stater, 92262
    - Novartis Investigative Site
  - Pasadena, California, Forenede Stater, 91105
    - Novartis Investigative Site
  - Pomona, California, Forenede Stater, 91767
    - Novartis Investigative Site
  - Sacramento, California, Forenede Stater, 95819
    - Novartis Investigative Site
  - Sacramento, California, Forenede Stater, 95816
    - Novartis Investigative Site
  - San Diego, California, Forenede Stater, 92101
    - Novartis Investigative Site
  - San Diego, California, Forenede Stater, 92120
    - Novartis Investigative Site
  - San Diego, California, Forenede Stater, 92161
    - Novartis Investigative Site
  - San Diego, California, Forenede Stater, 92128
    - Novartis Investigative Site
  - San Francisco, California, Forenede Stater, 94143-0792
    - Novartis Investigative Site
  - Santa Ana, California, Forenede Stater, 92704
    - Novartis Investigative Site
  - Santa Rosa, California, Forenede Stater, 95405
    - Novartis Investigative Site
  - Torrance, California, Forenede Stater, 90502
    - Novartis Investigative Site
  - Tustin, California, Forenede Stater, 92780
    - Novartis Investigative Site
  - Visalia, California, Forenede Stater, 93291
    - Novartis Investigative Site
  - Walnut Creek, California, Forenede Stater, 94598
    - Novartis Investigative Site
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Novartis Investigative Site
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Novartis Investigative Site
  - Denver, Colorado, Forenede Stater, 80206
    - Novartis Investigative Site
  - Denver, Colorado, Forenede Stater, 80218
    - Novartis Investigative Site
  - Denver, Colorado, Forenede Stater, 80220
    - Novartis Investigative Site
  - Denver, Colorado, Forenede Stater, 80204-4507
    - Novartis Investigative Site
- Connecticut
  - Norwich, Connecticut, Forenede Stater, 06360
    - Novartis Investigative Site
- Delaware
  - Newark, Delaware, Forenede Stater, 19713
    - Novartis Investigative Site
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20010
    - Novartis Investigative Site
  - Washington, District of Columbia, Forenede Stater, 20037
    - Novartis Investigative Site
- Florida
  - Clearwater, Florida, Forenede Stater, 33756
    - Novartis Investigative Site
  - Coral Springs, Florida, Forenede Stater, 33065
    - Novartis Investigative Site
  - Davie, Florida, Forenede Stater, 33324
    - Novartis Investigative Site
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Novartis Investigative Site
  - DeFuniak Springs, Florida, Forenede Stater, 32435
    - Novartis Investigative Site
  - Doral, Florida, Forenede Stater, 33136
    - Novartis Investigative Site
  - Hialeah, Florida, Forenede Stater, 33012
    - Novartis Investigative Site
  - Hollywood, Florida, Forenede Stater, 33021
    - Novartis Investigative Site
  - Hollywood, Florida, Forenede Stater, 33312
    - Novartis Investigative Site
  - Jacksonville, Florida, Forenede Stater, 32204
    - Novartis Investigative Site
  - Jacksonville, Florida, Forenede Stater, 32216
    - Novartis Investigative Site
  - Jacksonville, Florida, Forenede Stater, 32223
    - Novartis Investigative Site
  - Jacksonville, Florida, Forenede Stater, 32209-6511
    - Novartis Investigative Site
  - Jacksonville Beach, Florida, Forenede Stater, 32050
    - Novartis Investigative Site
  - Jupiter, Florida, Forenede Stater, 33458
    - Novartis Investigative Site
  - Miami, Florida, Forenede Stater, 33126
    - Novartis Investigative Site
  - Miami, Florida, Forenede Stater, 33135
    - Novartis Investigative Site
  - Miami, Florida, Forenede Stater, 33176
    - Novartis Investigative Site
  - Miami, Florida, Forenede Stater, 33155
    - Novartis Investigative Site
  - Miami Beach, Florida, Forenede Stater, 33140
    - Novartis Investigative Site
  - Naples, Florida, Forenede Stater, 34119
    - Novartis Investigative Site
  - Orlando, Florida, Forenede Stater, 32822
    - Novartis Investigative Site
  - Pembroke Pines, Florida, Forenede Stater, 33024
    - Novartis Investigative Site
  - Pinellas Park, Florida, Forenede Stater, 33781
    - Novartis Investigative Site
  - Port Charlotte, Florida, Forenede Stater, 33952
    - Novartis Investigative Site
  - Port Orange, Florida, Forenede Stater, 32127
    - Novartis Investigative Site
  - Sarasota, Florida, Forenede Stater, 34239
    - Novartis Investigative Site
  - South Miami, Florida, Forenede Stater, 33143
    - Novartis Investigative Site
  - Tampa, Florida, Forenede Stater, 33624
    - Novartis Investigative Site
  - Tampa, Florida, Forenede Stater, 33613
    - Novartis Investigative Site
  - Wellington, Florida, Forenede Stater, 33449
    - Novartis Investigative Site
- Georgia
  - Athens, Georgia, Forenede Stater, 30606
    - Novartis Investigative Site
  - Augusta, Georgia, Forenede Stater, 30904
    - Novartis Investigative Site
  - Covington, Georgia, Forenede Stater, 30014
    - Novartis Investigative Site
  - Cumming, Georgia, Forenede Stater, 30041
    - Novartis Investigative Site
  - Decatur, Georgia, Forenede Stater, 30033
    - Novartis Investigative Site
  - Decatur, Georgia, Forenede Stater, 30035
    - Novartis Investigative Site
  - Duluth, Georgia, Forenede Stater, 30096
    - Novartis Investigative Site
  - Macon, Georgia, Forenede Stater, 31201
    - Novartis Investigative Site
  - Roswell, Georgia, Forenede Stater, 30076
    - Novartis Investigative Site
  - Savannah, Georgia, Forenede Stater, 31406
    - Novartis Investigative Site
  - Thomasville, Georgia, Forenede Stater, 31792
    - Novartis Investigative Site
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96814
    - Novartis Investigative Site
- Idaho
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Novartis Investigative Site
- Illinois
  - Chicago, Illinois, Forenede Stater, 60611
    - Novartis Investigative Site
  - Jerseyville, Illinois, Forenede Stater, 62052
    - Novartis Investigative Site
  - Lombard, Illinois, Forenede Stater, 60148
    - Novartis Investigative Site
  - Melrose Park, Illinois, Forenede Stater, 60160
    - Novartis Investigative Site
  - Peoria, Illinois, Forenede Stater, 61602
    - Novartis Investigative Site
- Indiana
  - Evansville, Indiana, Forenede Stater, 47712
    - Novartis Investigative Site
  - Evansville, Indiana, Forenede Stater, 47714
    - Novartis Investigative Site
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Novartis Investigative Site
  - Waterloo, Iowa, Forenede Stater, 50702
    - Novartis Investigative Site
- Kansas
  - Kansas City, Kansas, Forenede Stater, 66160
    - Novartis Investigative Site
  - Overland Park, Kansas, Forenede Stater, 66204
    - Novartis Investigative Site
  - Topeka, Kansas, Forenede Stater, 66606
    - Novartis Investigative Site
  - Wichita, Kansas, Forenede Stater, 67214
    - Novartis Investigative Site
  - Wichita, Kansas, Forenede Stater, 67207
    - Novartis Investigative Site
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40509
    - Novartis Investigative Site
  - Louisville, Kentucky, Forenede Stater, 40206
    - Novartis Investigative Site
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Novartis Investigative Site
  - Owensboro, Kentucky, Forenede Stater, 42303
    - Novartis Investigative Site
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70808
    - Novartis Investigative Site
  - Baton Rouge, Louisiana, Forenede Stater, 70816
    - Novartis Investigative Site
  - Covington, Louisiana, Forenede Stater, 70433
    - Novartis Investigative Site
  - Houma, Louisiana, Forenede Stater, 70360
    - Novartis Investigative Site
  - Lafayette, Louisiana, Forenede Stater, 70501
    - Novartis Investigative Site
  - Lafayette, Louisiana, Forenede Stater, 70508
    - Novartis Investigative Site
  - Mandeville, Louisiana, Forenede Stater, 70471
    - Novartis Investigative Site
  - Metairie, Louisiana, Forenede Stater, 70006
    - Novartis Investigative Site
  - Metairie, Louisiana, Forenede Stater, 70001
    - Novartis Investigative Site
  - Minden, Louisiana, Forenede Stater, 71055
    - Novartis Investigative Site
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Novartis Investigative Site
  - New Orleans, Louisiana, Forenede Stater, 70119
    - Novartis Investigative Site
  - Opelousas, Louisiana, Forenede Stater, 70570
    - Novartis Investigative Site
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Novartis Investigative Site
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Novartis Investigative Site
  - Slidell, Louisiana, Forenede Stater, 70458
    - Novartis Investigative Site
  - Winnsboro, Louisiana, Forenede Stater, 71295
    - Novartis Investigative Site
  - Zachary, Louisiana, Forenede Stater, 70791
    - Novartis Investigative Site
- Maine
  - Portland, Maine, Forenede Stater, 04102
    - Novartis Investigative Site
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21204
    - Novartis Investigative Site
  - Beltsville, Maryland, Forenede Stater, 20705
    - Novartis Investigative Site
  - Columbia, Maryland, Forenede Stater, 21044
    - Novartis Investigative Site
- Massachusetts
  - Burlington, Massachusetts, Forenede Stater, 01803
    - Novartis Investigative Site
  - Fall River, Massachusetts, Forenede Stater, 02720
    - Novartis Investigative Site
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Novartis Investigative Site
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Novartis Investigative Site
  - Chelsea, Michigan, Forenede Stater, 48118
    - Novartis Investigative Site
  - Detroit, Michigan, Forenede Stater, 48202
    - Novartis Investigative Site
  - Grand Blanc, Michigan, Forenede Stater, 48439
    - Novartis Investigative Site
  - Kalamazoo, Michigan, Forenede Stater, 49008
    - Novartis Investigative Site
  - Midland, Michigan, Forenede Stater, 48640
    - Novartis Investigative Site
  - Novi, Michigan, Forenede Stater, 48374
    - Novartis Investigative Site
  - Petoskey, Michigan, Forenede Stater, 49770
    - Novartis Investigative Site
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Novartis Investigative Site
  - Saginaw, Michigan, Forenede Stater, 48601
    - Novartis Investigative Site
  - Wyoming, Michigan, Forenede Stater, 49519
    - Novartis Investigative Site
- Minnesota
  - Bloomington, Minnesota, Forenede Stater, 55420
    - Novartis Investigative Site
  - Duluth, Minnesota, Forenede Stater, 55805
    - Novartis Investigative Site
  - Edina, Minnesota, Forenede Stater, 55435
    - Novartis Investigative Site
  - Fridley, Minnesota, Forenede Stater, 55432
    - Novartis Investigative Site
  - Minneapolis, Minnesota, Forenede Stater, 55433
    - Novartis Investigative Site
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - Novartis Investigative Site
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Novartis Investigative Site
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - Novartis Investigative Site
- Mississippi
  - Hattiesburg, Mississippi, Forenede Stater, 39401
    - Novartis Investigative Site
  - Jackson, Mississippi, Forenede Stater, 39209
    - Novartis Investigative Site
  - Picayune, Mississippi, Forenede Stater, 39466
    - Novartis Investigative Site
- Missouri
  - Columbia, Missouri, Forenede Stater, 65212
    - Novartis Investigative Site
  - Kansas City, Missouri, Forenede Stater, 64111
    - Novartis Investigative Site
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Novartis Investigative Site
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Novartis Investigative Site
  - Saint Louis, Missouri, Forenede Stater, 63128
    - Novartis Investigative Site
  - Springfield, Missouri, Forenede Stater, 65807
    - Novartis Investigative Site
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Novartis Investigative Site
  - Lincoln, Nebraska, Forenede Stater, 68516
    - Novartis Investigative Site
  - Omaha, Nebraska, Forenede Stater, 68114
    - Novartis Investigative Site
  - Omaha, Nebraska, Forenede Stater, 68131
    - Novartis Investigative Site
  - Omaha, Nebraska, Forenede Stater, 68134
    - Novartis Investigative Site
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89118
    - Novartis Investigative Site
- New Hampshire
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Novartis Investigative Site
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Novartis Investigative Site
  - Freehold, New Jersey, Forenede Stater, 07728
    - Novartis Investigative Site
  - Lodi, New Jersey, Forenede Stater, 07644
    - Novartis Investigative Site
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - Novartis Investigative Site
  - Ocean City, New Jersey, Forenede Stater, 07712
    - Novartis Investigative Site
  - Pomona, New Jersey, Forenede Stater, 08240
    - Novartis Investigative Site
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Novartis Investigative Site
  - Westwood, New Jersey, Forenede Stater, 07675
    - Novartis Investigative Site
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Novartis Investigative Site
- New York
  - Binghamton, New York, Forenede Stater, 13901
    - Novartis Investigative Site
  - Endwell, New York, Forenede Stater, 13760
    - Novartis Investigative Site
  - Kew Gardens, New York, Forenede Stater, 11415
    - Novartis Investigative Site
  - Mineola, New York, Forenede Stater, 11501
    - Novartis Investigative Site
  - New York, New York, Forenede Stater, 10003
    - Novartis Investigative Site
  - New York, New York, Forenede Stater, 10016
    - Novartis Investigative Site
  - New York, New York, Forenede Stater, 10035
    - Novartis Investigative Site
  - Rochester, New York, Forenede Stater, 14621
    - Novartis Investigative Site
  - Rochester, New York, Forenede Stater, 14609
    - Novartis Investigative Site
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27204
    - Novartis Investigative Site
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Novartis Investigative Site
  - Greensboro, North Carolina, Forenede Stater, 27401
    - Novartis Investigative Site
  - Greensboro, North Carolina, Forenede Stater, 27410
    - Novartis Investigative Site
  - Greenville, North Carolina, Forenede Stater, 27834
    - Novartis Investigative Site
  - Hickory, North Carolina, Forenede Stater, 28601
    - Novartis Investigative Site
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Novartis Investigative Site
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - Novartis Investigative Site
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Novartis Investigative Site
  - Sanford, North Carolina, Forenede Stater, 27330
    - Novartis Investigative Site
  - Statesville, North Carolina, Forenede Stater, 28625
    - Novartis Investigative Site
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novartis Investigative Site
  - Winston-Salem, North Carolina, Forenede Stater, 27106
    - Novartis Investigative Site
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58122
    - Novartis Investigative Site
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Novartis Investigative Site
- Ohio
  - Akron, Ohio, Forenede Stater, 44309
    - Novartis Investigative Site
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Novartis Investigative Site
  - Cincinnati, Ohio, Forenede Stater, 45245
    - Novartis Investigative Site
  - Cleveland, Ohio, Forenede Stater, 44109-1998
    - Novartis Investigative Site
  - Columbus, Ohio, Forenede Stater, 43235
    - Novartis Investigative Site
  - Dayton, Ohio, Forenede Stater, 45402
    - Novartis Investigative Site
  - Marion, Ohio, Forenede Stater, 43302
    - Novartis Investigative Site
- Oklahoma
  - Bartlesville, Oklahoma, Forenede Stater, 74006
    - Novartis Investigative Site
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Novartis Investigative Site
  - Tulsa, Oklahoma, Forenede Stater, 74133
    - Novartis Investigative Site
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - Novartis Investigative Site
  - Portland, Oregon, Forenede Stater, 97225
    - Novartis Investigative Site
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Novartis Investigative Site
  - Altoona, Pennsylvania, Forenede Stater, 16602
    - Novartis Investigative Site
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - Novartis Investigative Site
  - Bridgeville, Pennsylvania, Forenede Stater, 15017
    - Novartis Investigative Site
  - Camp Hill, Pennsylvania, Forenede Stater, 17011
    - Novartis Investigative Site
  - Erie, Pennsylvania, Forenede Stater, 16507
    - Novartis Investigative Site
  - Hershey, Pennsylvania, Forenede Stater, 17033
    - Novartis Investigative Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - Novartis Investigative Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15216
    - Novartis Investigative Site
  - Pittsburgh, Pennsylvania, Forenede Stater, 15236
    - Novartis Investigative Site
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Novartis Investigative Site
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - Novartis Investigative Site
- Rhode Island
  - Cumberland, Rhode Island, Forenede Stater, 02864-1410
    - Novartis Investigative Site
  - Providence, Rhode Island, Forenede Stater, 02906
    - Novartis Investigative Site
  - Providence, Rhode Island, Forenede Stater, 02904
    - Novartis Investigative Site
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - Novartis Investigative Site
  - Columbia, South Carolina, Forenede Stater, 29201
    - Novartis Investigative Site
  - Fort Mill, South Carolina, Forenede Stater, 29707
    - Novartis Investigative Site
  - Greenville, South Carolina, Forenede Stater, 29605
    - Novartis Investigative Site
  - Greer, South Carolina, Forenede Stater, 29651
    - Novartis Investigative Site
  - Moncks Corner, South Carolina, Forenede Stater, 29461
    - Novartis Investigative Site
  - Mount Pleasant, South Carolina, Forenede Stater, 29464
    - Novartis Investigative Site
  - North Myrtle Beach, South Carolina, Forenede Stater, 29582
    - Novartis Investigative Site
  - Orangeburg, South Carolina, Forenede Stater, 29115
    - Novartis Investigative Site
  - Varnville, South Carolina, Forenede Stater, 29944
    - Novartis Investigative Site
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Novartis Investigative Site
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Novartis Investigative Site
- Tennessee
  - Germantown, Tennessee, Forenede Stater, 38138
    - Novartis Investigative Site
  - Greenville, Tennessee, Forenede Stater, 37745
    - Novartis Investigative Site
  - Jackson, Tennessee, Forenede Stater, 38305
    - Novartis Investigative Site
  - Johnson City, Tennessee, Forenede Stater, 37604
    - Novartis Investigative Site
  - Knoxville, Tennessee, Forenede Stater, 37920
    - Novartis Investigative Site
  - Knoxville, Tennessee, Forenede Stater, 37917
    - Novartis Investigative Site
  - Knoxville, Tennessee, Forenede Stater, 37934
    - Novartis Investigative Site
  - Memphis, Tennessee, Forenede Stater, 38120
    - Novartis Investigative Site
- Texas
  - Allen, Texas, Forenede Stater, 75002-3688
    - Novartis Investigative Site
  - Beaumont, Texas, Forenede Stater, 77702
    - Novartis Investigative Site
  - Beaumont, Texas, Forenede Stater, 77701
    - Novartis Investigative Site
  - Bedford, Texas, Forenede Stater, 76021
    - Novartis Investigative Site
  - Brownsville, Texas, Forenede Stater, 78520
    - Novartis Investigative Site
  - Dallas, Texas, Forenede Stater, 75226
    - Novartis Investigative Site
  - Dallas, Texas, Forenede Stater, 75204
    - Novartis Investigative Site
  - Dallas, Texas, Forenede Stater, 75231
    - Novartis Investigative Site
  - Gonzales, Texas, Forenede Stater, 78629
    - Novartis Investigative Site
  - Greenville, Texas, Forenede Stater, 75401
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77030
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77025
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77081
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77070
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77055
    - Novartis Investigative Site
  - Houston, Texas, Forenede Stater, 77064
    - Novartis Investigative Site
  - Irving, Texas, Forenede Stater, 75039
    - Novartis Investigative Site
  - Lake Jackson, Texas, Forenede Stater, 77566
    - Novartis Investigative Site
  - Leander, Texas, Forenede Stater, 78641
    - Novartis Investigative Site
  - Livingston, Texas, Forenede Stater, 77351
    - Novartis Investigative Site
  - Lufkin, Texas, Forenede Stater, 75904
    - Novartis Investigative Site
  - Marshall, Texas, Forenede Stater, 75670
    - Novartis Investigative Site
  - McAllen, Texas, Forenede Stater, 78501
    - Novartis Investigative Site
  - McKinney, Texas, Forenede Stater, 75069
    - Novartis Investigative Site
  - Odessa, Texas, Forenede Stater, 79761
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78229
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78258
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78234
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78212
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78229-4801
    - Novartis Investigative Site
  - San Antonio, Texas, Forenede Stater, 78238-7676
    - Novartis Investigative Site
  - Sugar Land, Texas, Forenede Stater, 77479
    - Novartis Investigative Site
  - Temple, Texas, Forenede Stater, 76508
    - Novartis Investigative Site
  - Tomball, Texas, Forenede Stater, 77375
    - Novartis Investigative Site
  - Waco, Texas, Forenede Stater, 76710
    - Novartis Investigative Site
  - Webster, Texas, Forenede Stater, 77598
    - Novartis Investigative Site
- Utah
  - Bountiful, Utah, Forenede Stater, 84010
    - Novartis Investigative Site
  - Layton, Utah, Forenede Stater, 84041
    - Novartis Investigative Site
  - Salt Lake City, Utah, Forenede Stater, 84107
    - Novartis Investigative Site
  - Salt Lake City, Utah, Forenede Stater, 84124
    - Novartis Investigative Site
  - Salt Lake City, Utah, Forenede Stater, 84102
    - Novartis Investigative Site
- Virginia
  - Burke, Virginia, Forenede Stater, 22015
    - Novartis Investigative Site
  - Danville, Virginia, Forenede Stater, 24541
    - Novartis Investigative Site
  - Hopewell, Virginia, Forenede Stater, 23860
    - Novartis Investigative Site
  - Richmond, Virginia, Forenede Stater, 23298
    - Novartis Investigative Site
  - Richmond, Virginia, Forenede Stater, 23249
    - Novartis Investigative Site
- Washington
  - Port Orchard, Washington, Forenede Stater, 98366
    - Novartis Investigative Site
  - Renton, Washington, Forenede Stater, 98057
    - Novartis Investigative Site
  - Seattle, Washington, Forenede Stater, 98104
    - Novartis Investigative Site
  - Seattle, Washington, Forenede Stater, 98122
    - Novartis Investigative Site
  - Tacoma, Washington, Forenede Stater, 98405
    - Novartis Investigative Site
- Wisconsin
  - Madison, Wisconsin, Forenede Stater, 53713
    - Novartis Investigative Site
Grækenland
- - Athens, Grækenland, 115 27
    - Novartis Investigative Site
  - Athens, Grækenland, 12462
    - Novartis Investigative Site
  - Athens, Grækenland, 106 76
    - Novartis Investigative Site
  - Chalkida, Grækenland, GR 341 00
    - Novartis Investigative Site
  - Crete Heraklion, Grækenland, 714 09
    - Novartis Investigative Site
  - Heraklion Crete, Grækenland, 711 10
    - Novartis Investigative Site
  - Patras, Grækenland, 265 00
    - Novartis Investigative Site
- GR
  - Athens, GR, Grækenland, 14233
    - Novartis Investigative Site
  - Magoula, GR, Grækenland, 190 18
    - Novartis Investigative Site
  - Thessaloniki, GR, Grækenland, 570 10
    - Novartis Investigative Site
  - Thessaloniki, GR, Grækenland, 564 03
    - Novartis Investigative Site
  - Voula, GR, Grækenland, 166 73
    - Novartis Investigative Site
Guatemala
- - Guatemala, Guatemala, 01010
    - Novartis Investigative Site
  - Guatemala City, Guatemala, 01010
    - Novartis Investigative Site
  - Guatemala City, Guatemala, 01001
    - Novartis Investigative Site
  - Guatemala City, Guatemala, 01011
    - Novartis Investigative Site
  - Guatemala City, Guatemala, 01015
    - Novartis Investigative Site
Holland
- - Alkmaar, Holland, 1815 JD
    - Novartis Investigative Site
  - Amersfoort, Holland, 3813 TZ
    - Novartis Investigative Site
  - Amstelveen, Holland, 1186 AM
    - Novartis Investigative Site
  - Amsterdam, Holland, 1090 HM
    - Novartis Investigative Site
  - Amsterdam, Holland, 1105 AZ
    - Novartis Investigative Site
  - Breda, Holland, 4811SW
    - Novartis Investigative Site
  - Deventer, Holland, 7416 SE
    - Novartis Investigative Site
  - Doetinchem, Holland, 7009 BL
    - Novartis Investigative Site
  - Ede, Holland, 6716 RP
    - Novartis Investigative Site
  - Gouda, Holland, 2803 HH
    - Novartis Investigative Site
  - Groningen, Holland, NL-9711 SG
    - Novartis Investigative Site
  - Haarlem, Holland, 2035 RC
    - Novartis Investigative Site
  - Heerlen, Holland, 6419 PC
    - Novartis Investigative Site
  - Hoorn, Holland, 1624 NP
    - Novartis Investigative Site
  - Leeuwarden, Holland, 8934 AD
    - Novartis Investigative Site
  - Meppel, Holland, 7943 KA
    - Novartis Investigative Site
  - Nijmegen, Holland
    - Novartis Investigative Site
  - Rotterdam, Holland, 3083 AN
    - Novartis Investigative Site
  - Rotterdam, Holland, 3001 HG
    - Novartis Investigative Site
  - Tiel, Holland, 4002 WP
    - Novartis Investigative Site
  - Utrecht, Holland, 3584 CX
    - Novartis Investigative Site
  - Venlo, Holland, 5912 BL
    - Novartis Investigative Site
- AZ
  - Maastricht, AZ, Holland, 5800
    - Novartis Investigative Site
- DZ
  - Apeldoorn, DZ, Holland, 7334
    - Novartis Investigative Site
- The Netherlands
  - Sneek, The Netherlands, Holland, 8601 ZR
    - Novartis Investigative Site
Indien
- - Ahmedabad, Indien, 380025
    - Novartis Investigative Site
  - Rajasthan, Indien, 324005
    - Novartis Investigative Site
- Andhra Pradesh
  - Hyderabad, Andhra Pradesh, Indien, 500001
    - Novartis Investigative Site
  - Hyderabad, Andhra Pradesh, Indien
    - Novartis Investigative Site
  - Nampally, Andhra Pradesh, Indien, 500 001
    - Novartis Investigative Site
  - Nellore, Andhra Pradesh, Indien, 524 003
    - Novartis Investigative Site
  - Tirupati, Andhra Pradesh, Indien, 517 5-7
    - Novartis Investigative Site
  - Vijayawada, Andhra Pradesh, Indien, 520 008
    - Novartis Investigative Site
  - Vijayawada, Andhra Pradesh, Indien, 520010
    - Novartis Investigative Site
  - Vishakhapatnam, Andhra Pradesh, Indien, 530 013
    - Novartis Investigative Site
- Andhrapradesh
  - Guntur, Andhrapradesh, Indien, 522001
    - Novartis Investigative Site
- Delhi
  - New Delhi, Delhi, Indien, 110060
    - Novartis Investigative Site
- Gujarat
  - Ahmedabad, Gujarat, Indien, 382428
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380 051
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380054
    - Novartis Investigative Site
  - Ahmedabad, Gujarat, Indien, 380006
    - Novartis Investigative Site
  - Surat, Gujarat, Indien, 395 002
    - Novartis Investigative Site
  - Surat, Gujarat, Indien, 395001
    - Novartis Investigative Site
  - Vadodara, Gujarat, Indien, 390015
    - Novartis Investigative Site
- Karnataka
  - Bangalore, Karnataka, Indien, 560 055
    - Novartis Investigative Site
  - Bengaluru, Karnataka, Indien, 560034
    - Novartis Investigative Site
  - Manipal, Karnataka, Indien, 576104
    - Novartis Investigative Site
- Kerala
  - Kochi, Kerala, Indien, 682 018
    - Novartis Investigative Site
- Maharashtra
  - Nagpur, Maharashtra, Indien, 440012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 400012
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 440 010
    - Novartis Investigative Site
  - Nagpur, Maharashtra, Indien, 44000033
    - Novartis Investigative Site
  - Nashik, Maharashtra, Indien, 422 005
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411004
    - Novartis Investigative Site
  - Pune, Maharashtra, Indien, 411005
    - Novartis Investigative Site
- Punjab
  - Ludhiana, Punjab, Indien, 141002
    - Novartis Investigative Site
  - Ludhiana, Punjab, Indien, 141421
    - Novartis Investigative Site
  - Ludhiana, Punjab, Indien, 141012
    - Novartis Investigative Site
  - Mohali, Punjab, Indien, 160 062
    - Novartis Investigative Site
- Rajasthan
  - Bikaner, Rajasthan, Indien, 334003
    - Novartis Investigative Site
  - Jaipur, Rajasthan, Indien, 302016
    - Novartis Investigative Site
  - Jaipur, Rajasthan, Indien, 302024
    - Novartis Investigative Site
- Tamil NADU
  - Madurai, Tamil NADU, Indien, 625107
    - Novartis Investigative Site
- Tamil Nadu
  - Chennai, Tamil Nadu, Indien, 600081
    - Novartis Investigative Site
  - Coimbatore, Tamil Nadu, Indien, 641037
    - Novartis Investigative Site
- Tamilnadu
  - Coimbatore, Tamilnadu, Indien, 641 018
    - Novartis Investigative Site
- Telangana
  - Hyderabad, Telangana, Indien, 500 063
    - Novartis Investigative Site
  - Secunderabad, Telangana, Indien, 500003
    - Novartis Investigative Site
- Uttar Pradesh
  - Ghaziabad, Uttar Pradesh, Indien
    - Novartis Investigative Site
  - Lucknow, Uttar Pradesh, Indien, 226005
    - Novartis Investigative Site
  - Varanasi, Uttar Pradesh, Indien, 224105
    - Novartis Investigative Site
Island
- - Kopavogur, Island, 201
    - Novartis Investigative Site
  - Reykjavik, Island, IS-109
    - Novartis Investigative Site
  - Reykjavik, Island, IS-101
    - Novartis Investigative Site
Italien
- - Napoli, Italien, 80131
    - Novartis Investigative Site
  - Novara, Italien, 28100
    - Novartis Investigative Site
  - Veruno, Italien, 28010
    - Novartis Investigative Site
- AN
  - Ancona, AN, Italien, 60128
    - Novartis Investigative Site
- AP
  - Fermo, AP, Italien, 63023
    - Novartis Investigative Site
- AR
  - Cortona, AR, Italien, 52044
    - Novartis Investigative Site
- BG
  - Bergamo, BG, Italien, 24127
    - Novartis Investigative Site
  - Treviglio, BG, Italien, 24047
    - Novartis Investigative Site
- BS
  - Brescia, BS, Italien, 25123
    - Novartis Investigative Site
  - Montichiari, BS, Italien, 25018
    - Novartis Investigative Site
- CA
  - Monserrato, CA, Italien, 09042
    - Novartis Investigative Site
- CE
  - Santa Maria Capua Vetere, CE, Italien, 81055
    - Novartis Investigative Site
- CH
  - Chieti, CH, Italien, 66100
    - Novartis Investigative Site
- CZ
  - Catanzaro, CZ, Italien, 88100
    - Novartis Investigative Site
- FE
  - Cona, FE, Italien, 44100
    - Novartis Investigative Site
- FG
  - Foggia, FG, Italien, 71100
    - Novartis Investigative Site
- FI
  - Firenze, FI, Italien, 50134
    - Novartis Investigative Site
- IS
  - Pozzilli, IS, Italien, 86077
    - Novartis Investigative Site
- MI
  - Milano, MI, Italien, 20132
    - Novartis Investigative Site
  - Milano, MI, Italien, 20100
    - Novartis Investigative Site
  - Milano, MI, Italien, 20145
    - Novartis Investigative Site
  - Rozzano, MI, Italien, 20089
    - Novartis Investigative Site
- MS
  - Massa, MS, Italien, 54100
    - Novartis Investigative Site
- PA
  - Palermo, PA, Italien, 90129
    - Novartis Investigative Site
- PC
  - Piacenza, PC, Italien, 29100
    - Novartis Investigative Site
- PI
  - Pisa, PI, Italien, 56126
    - Novartis Investigative Site
- PR
  - Parma, PR, Italien, 43100
    - Novartis Investigative Site
- PV
  - Casorate Primo, PV, Italien, 27022
    - Novartis Investigative Site
  - Pavia, PV, Italien, 27100
    - Novartis Investigative Site
- RM
  - Roma, RM, Italien, 00168
    - Novartis Investigative Site
  - Roma, RM, Italien, 00161
    - Novartis Investigative Site
  - Roma, RM, Italien, 00189
    - Novartis Investigative Site
- SS
  - Sassari, SS, Italien, 07100
    - Novartis Investigative Site
- UD
  - Palmanova, UD, Italien, 33057
    - Novartis Investigative Site
  - San Daniele Del Friuli, UD, Italien, 33038
    - Novartis Investigative Site
- VR
  - Verona, VR, Italien, 37134
    - Novartis Investigative Site
- VV
  - Soriano Calabro, VV, Italien, 89831
    - Novartis Investigative Site
Japan
- Aichi
  - Ichinomiya, Aichi, Japan, 491-8551
    - Novartis Investigative Site
  - Nagoya, Aichi, Japan, 453-8511
    - Novartis Investigative Site
  - Seto-city, Aichi, Japan, 489-8642
    - Novartis Investigative Site
- Chiba
  - Funabashi, Chiba, Japan, 273-8588
    - Novartis Investigative Site
  - Matsudo city, Chiba, Japan, 271 0077
    - Novartis Investigative Site
  - Matsudo-city, Chiba, Japan, 270-2251
    - Novartis Investigative Site
- Fukuoka
  - Kasuga, Fukuoka, Japan, 816-0864
    - Novartis Investigative Site
  - Kurume-city, Fukuoka, Japan, 830-8577
    - Novartis Investigative Site
  - Onga-gun, Fukuoka, Japan, 807-0051
    - Novartis Investigative Site
  - Yukuhashi, Fukuoka, Japan, 824-0026
    - Novartis Investigative Site
- Gifu
  - Ogaki-city, Gifu, Japan, 503-8502
    - Novartis Investigative Site
- Gunma
  - Fujioka city, Gunma, Japan, 375-8503
    - Novartis Investigative Site
  - Takasaki-city, Gunma, Japan, 370-0036
    - Novartis Investigative Site
- Hiroshima
  - Hatsukaichi city, Hiroshima, Japan, 738 8503
    - Novartis Investigative Site
- Hyogo
  - Amagasaki city, Hyogo, Japan, 660 8550
    - Novartis Investigative Site
  - Amagasaki-city, Hyogo, Japan, 661-0976
    - Novartis Investigative Site
  - Nishinomiya, Hyogo, Japan, 663 8501
    - Novartis Investigative Site
  - Takarazuka-city, Hyogo, Japan, 665-0022
    - Novartis Investigative Site
- Ibaraki
  - Higashiibaraki-gun, Ibaraki, Japan, 311-3193
    - Novartis Investigative Site
  - Hitachi-city, Ibaraki, Japan, 317-0077
    - Novartis Investigative Site
- Kagawa
  - Sakaide-city, Kagawa, Japan, 762-0007
    - Novartis Investigative Site
  - Takamatsu city, Kagawa, Japan, 760 8557
    - Novartis Investigative Site
- Kanagawa
  - Yokohama, Kanagawa, Japan, 234-0054
    - Novartis Investigative Site
- Kumamoto
  - Kumamoto City, Kumamoto, Japan, 860-8556
    - Novartis Investigative Site
- Kyoto
  - Kyoto-city, Kyoto, Japan, 607-8062
    - Novartis Investigative Site
- Miyagi
  - Sendai city, Miyagi, Japan, 980 8574
    - Novartis Investigative Site
  - Sendai-shi, Miyagi, Japan, 983 8520
    - Novartis Investigative Site
- Nagano
  - Nagano City, Nagano, Japan, 380 0814
    - Novartis Investigative Site
- Osaka
  - Hirakata-City, Osaka, Japan, 573-0153
    - Novartis Investigative Site
  - Osaka-city, Osaka, Japan, 543-0035
    - Novartis Investigative Site
  - Osaka-city, Osaka, Japan, 543-8555
    - Novartis Investigative Site
  - Osaka-city, Osaka, Japan, 558-8558
    - Novartis Investigative Site
  - Takatsuki, Osaka, Japan, 569-0852
    - Novartis Investigative Site
- Saitama
  - Sayama-city, Saitama, Japan, 350-1305
    - Novartis Investigative Site
  - Tokorozawa, Saitama, Japan, 359-1142
    - Novartis Investigative Site
- Shiga
  - Kusatsu-city, Shiga, Japan, 525-0014
    - Novartis Investigative Site
- Tokushima
  - Komatsushima-city, Tokushima, Japan, 773-8502
    - Novartis Investigative Site
- Tokyo
  - Bunkyo-ku, Tokyo, Japan, 113-8603
    - Novartis Investigative Site
  - Chiyoda-ku, Tokyo, Japan, 101-8309
    - Novartis Investigative Site
  - Chiyoda-ku, Tokyo, Japan, 101-8643
    - Novartis Investigative Site
  - Fuchu-city, Tokyo, Japan, 183-0003
    - Novartis Investigative Site
  - Itabashi-ku, Tokyo, Japan, 173-8610
    - Novartis Investigative Site
Kalkun
- - Aydin, Kalkun, 09100
    - Novartis Investigative Site
  - Istanbul, Kalkun, 34304
    - Novartis Investigative Site
  - Izmir, Kalkun, 35040
    - Novartis Investigative Site
  - Izmir, Kalkun, 35340
    - Novartis Investigative Site
  - Kocaeli, Kalkun, 41380
    - Novartis Investigative Site
  - Mersin, Kalkun, 33079
    - Novartis Investigative Site
  - Sivas, Kalkun, 58140
    - Novartis Investigative Site
- Meselik
  - Eskisehir, Meselik, Kalkun, 26480
    - Novartis Investigative Site
Kina
- - Beijing, Kina, 100029
    - Novartis Investigative Site
  - Beijing, Kina, 100034
    - Novartis Investigative Site
  - Beijing, Kina, 100028
    - Novartis Investigative Site
  - Beijing, Kina, 100176
    - Novartis Investigative Site
  - Beijing, Kina, 100010
    - Novartis Investigative Site
  - Beijing, Kina, 100038
    - Novartis Investigative Site
  - Shanghai, Kina, 200080
    - Novartis Investigative Site
  - Tianjin, Kina, 30045
    - Novartis Investigative Site
  - Tianjin, Kina, 300142
    - Novartis Investigative Site
- Beijing
  - Beijing, Beijing, Kina, 100730
    - Novartis Investigative Site
- Chongqing
  - Chongqing, Chongqing, Kina, 400010
    - Novartis Investigative Site
- Fujian
  - Fuzhou, Fujian, Kina
    - Novartis Investigative Site
- Guangdong
  - Guang Zhou, Guangdong, Kina, 510000
    - Novartis Investigative Site
  - Guangzhou, Guangdong, Kina, 51000
    - Novartis Investigative Site
- Guangxi
  - Nanning, Guangxi, Kina, 530021
    - Novartis Investigative Site
- Hebei
  - Shijiazhuang, Hebei, Kina, 050000
    - Novartis Investigative Site
- Heilongjiang
  - Harbin, Heilongjiang, Kina, 150000
    - Novartis Investigative Site
- Hubei
  - Wuhan, Hubei, Kina, 430060
    - Novartis Investigative Site
  - Wuhan, Hubei, Kina, 430022
    - Novartis Investigative Site
- Hunan
  - Changsha, Hunan, Kina, 410003
    - Novartis Investigative Site
- Inner Mongolia
  - Baotou, Inner Mongolia, Kina, 014040
    - Novartis Investigative Site
- Jiangsu
  - Nanjing, Jiangsu, Kina, 210009
    - Novartis Investigative Site
  - Suzhou, Jiangsu, Kina, 215006
    - Novartis Investigative Site
- Jilin
  - Changchun, Jilin, Kina, 130033
    - Novartis Investigative Site
- Liaoning
  - Shenyang, Liaoning, Kina, 110003
    - Novartis Investigative Site
  - Shenyang, Liaoning, Kina, 110016
    - Novartis Investigative Site
- Shanghai
  - Shanghai, Shanghai, Kina, 200032
    - Novartis Investigative Site
  - Shanghai, Shanghai, Kina
    - Novartis Investigative Site
  - Shanghai City, Shanghai, Kina, 200120
    - Novartis Investigative Site
- Shanxi
  - Xian, Shanxi, Kina, 710061
    - Novartis Investigative Site
  - Xian, Shanxi, Kina, 710004
    - Novartis Investigative Site
- Tianjin
  - Tianjin, Tianjin, Kina, 300121
    - Novartis Investigative Site
- Zhejiang
  - Hangzhou, Zhejiang, Kina, 310016
    - Novartis Investigative Site
  - Hangzhou, Zhejiang, Kina, 310013
    - Novartis Investigative Site
Korea, Republikken
- - Busan, Korea, Republikken, 49201
    - Novartis Investigative Site
  - Busan, Korea, Republikken, 602739
    - Novartis Investigative Site
  - Busan, Korea, Republikken, 612-896
    - Novartis Investigative Site
  - Daegu, Korea, Republikken, 705703
    - Novartis Investigative Site
  - Daegu, Korea, Republikken, 705 718
    - Novartis Investigative Site
  - Gwangju, Korea, Republikken, 61469
    - Novartis Investigative Site
  - Seoul, Korea, Republikken, 03722
    - Novartis Investigative Site
- Gangwon-Do
  - Wonju, Gangwon-Do, Korea, Republikken, 26426
    - Novartis Investigative Site
- Gyeonggi-do
  - Suwon, Gyeonggi-do, Korea, Republikken, 443380
    - Novartis Investigative Site
  - Uijeongbu-Si, Gyeonggi-do, Korea, Republikken, 480-717
    - Novartis Investigative Site
- Korea
  - Daejeon, Korea, Korea, Republikken, 35015
    - Novartis Investigative Site
  - Seoul, Korea, Korea, Republikken, 08308
    - Novartis Investigative Site
- Seocho Gu
  - Seoul, Seocho Gu, Korea, Republikken, 06591
    - Novartis Investigative Site
Kroatien
- - Cakovec, Kroatien, 40000
    - Novartis Investigative Site
  - Koprivnica, Kroatien, 48000
    - Novartis Investigative Site
  - Krapinske Toplice, Kroatien, 49217
    - Novartis Investigative Site
  - Krapinske toplice, Kroatien, 49 217
    - Novartis Investigative Site
  - Opatija, Kroatien, 51410
    - Novartis Investigative Site
  - Rijeka, Kroatien, 51000
    - Novartis Investigative Site
  - Virovitica, Kroatien, 33000
    - Novartis Investigative Site
  - Zagreb, Kroatien, 10000
    - Novartis Investigative Site
- HRV
  - Varazdin, HRV, Kroatien, 42000
    - Novartis Investigative Site
Letland
- - Daugavpils, Letland, LV-5417
    - Novartis Investigative Site
  - Riga, Letland, 1012
    - Novartis Investigative Site
  - Valmiera, Letland, 4201
    - Novartis Investigative Site
- LV
  - Liepaja, LV, Letland, LV-3414
    - Novartis Investigative Site
  - Riga, LV, Letland, LV-1005
    - Novartis Investigative Site
  - Ventspils, LV, Letland, LV-3601
    - Novartis Investigative Site
Litauen
- - Alytus, Litauen, LT-62386
    - Novartis Investigative Site
  - Kaunas, Litauen, LT-49387
    - Novartis Investigative Site
  - Kaunas, Litauen, LT-49449
    - Novartis Investigative Site
  - Kaunas, Litauen, LT-44320
    - Novartis Investigative Site
  - Kedainiai, Litauen, LT-57164
    - Novartis Investigative Site
  - Panevezys, Litauen, LT-37460
    - Novartis Investigative Site
  - Siauliai, Litauen, LT-76231
    - Novartis Investigative Site
  - Vilnius, Litauen, LT-08661
    - Novartis Investigative Site
- LTU
  - Kaunas, LTU, Litauen, LT 50161
    - Novartis Investigative Site
  - Klaipeda, LTU, Litauen, LT-92288
    - Novartis Investigative Site
Mexico
- - Aguascalientes, Mexico, 20230
    - Novartis Investigative Site
  - Queretaro, Mexico, 76000
    - Novartis Investigative Site
  - San Luis Potosi, Mexico, 78200
    - Novartis Investigative Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44280
    - Novartis Investigative Site
  - Guadalajara, Jalisco, Mexico, 44210
    - Novartis Investigative Site
- San Luis Potosí
  - San Luis Potosi, San Luis Potosí, Mexico, 78240
    - Novartis Investigative Site
- Sinaloa
  - Culiacan, Sinaloa, Mexico, 80230
    - Novartis Investigative Site
Norge
- - Alesund, Norge, NO-6026
    - Novartis Investigative Site
  - Elverum, Norge, 2408
    - Novartis Investigative Site
  - Hamar, Norge, 2317
    - Novartis Investigative Site
  - Harstad, Norge, 9481
    - Novartis Investigative Site
  - Hønefoss, Norge, 3501
    - Novartis Investigative Site
  - Lillehammer, Norge, 2629
    - Novartis Investigative Site
  - Moss, Norge, 1523
    - Novartis Investigative Site
  - Nesttun, Norge, 5221
    - Novartis Investigative Site
  - Oslo, Norge, 0424
    - Novartis Investigative Site
  - Oslo, Norge, 0303
    - Novartis Investigative Site
  - Sandefjord, Norge, 3211
    - Novartis Investigative Site
  - Skedsmokorset, Norge, 2020
    - Novartis Investigative Site
  - Stavanger, Norge, 4068
    - Novartis Investigative Site
  - Tonsberg, Norge, 3116
    - Novartis Investigative Site
  - Trondheim, Norge, 7011
    - Novartis Investigative Site
  - Tynset, Norge, 2501
    - Novartis Investigative Site
Peru
- - Lima, Peru, LIMA 39
    - Novartis Investigative Site
- Lima
  - Bellavista, Lima, Peru, CALLAO 02
    - Novartis Investigative Site
  - San Isidro, Lima, Peru, 27
    - Novartis Investigative Site
  - San Martin de Porres, Lima, Peru, 31
    - Novartis Investigative Site
Polen
- - Gdansk, Polen, 80-435
    - Novartis Investigative Site
  - Gdynia, Polen, 81-157
    - Novartis Investigative Site
  - Gdynia, Polen, 81-423
    - Novartis Investigative Site
  - Gdynia, Polen, 81-302
    - Novartis Investigative Site
  - Lublin, Polen, 20-538
    - Novartis Investigative Site
  - Olawa, Polen, 55-200
    - Novartis Investigative Site
  - Ostrow Wielkopolski, Polen, 63-400
    - Novartis Investigative Site
  - Poznan, Polen, 60-375
    - Novartis Investigative Site
  - Poznan, Polen, 61-874
    - Novartis Investigative Site
  - Pulawy, Polen, 24100
    - Novartis Investigative Site
  - Rumia, Polen, 84-230
    - Novartis Investigative Site
  - Skierniewice, Polen, 96-100
    - Novartis Investigative Site
  - Torun, Polen, 87-100
    - Novartis Investigative Site
  - Warszawa, Polen, 04-073
    - Novartis Investigative Site
  - Wegrow, Polen, 07-100
    - Novartis Investigative Site
  - Wloclawek, Polen, 87-800
    - Novartis Investigative Site
Puerto Rico
- - Manati, Puerto Rico, 00674
    - Novartis Investigative Site
  - Mayaguez, Puerto Rico, 00680
    - Novartis Investigative Site
  - Ponce, Puerto Rico, 00717
    - Novartis Investigative Site
  - Ponce, Puerto Rico, 00716
    - Novartis Investigative Site
  - San Juan, Puerto Rico, 00909
    - Novartis Investigative Site
  - San Juan, Puerto Rico, 00936-6528
    - Novartis Investigative Site
  - San Juan, Puerto Rico, 00926
    - Novartis Investigative Site
Rumænien
- - Baia Mare, Rumænien, 430123
    - Novartis Investigative Site
  - Brasov, Rumænien, 500283
    - Novartis Investigative Site
  - Bucharest, Rumænien, 021659
    - Novartis Investigative Site
  - Bucuresti, Rumænien, 011728
    - Novartis Investigative Site
  - Bucuresti, Rumænien, 011774
    - Novartis Investigative Site
  - Cluj Napoca, Rumænien, 400006
    - Novartis Investigative Site
  - Cluj-Napoca, Rumænien, 400347
    - Novartis Investigative Site
  - Craiova, Rumænien, 200642
    - Novartis Investigative Site
  - Oradea, Rumænien, 410169
    - Novartis Investigative Site
  - Pitesti, Rumænien, 110084
    - Novartis Investigative Site
  - Sibiu, Rumænien, 550371
    - Novartis Investigative Site
  - Targu Mures, Rumænien, 540142
    - Novartis Investigative Site
  - Targu Mures, Rumænien, 540096
    - Novartis Investigative Site
  - Targu-Mures, Rumænien, 540136
    - Novartis Investigative Site
  - Timisoara, Rumænien, 300736
    - Novartis Investigative Site
  - Timisoara, Rumænien, 300310
    - Novartis Investigative Site
- Arges
  - Pitesti, Arges, Rumænien, 110438
    - Novartis Investigative Site
- District 1
  - Bucharest, District 1, Rumænien
    - Novartis Investigative Site
  - Bucuresti, District 1, Rumænien, 010225
    - Novartis Investigative Site
- District 2
  - Bucharest, District 2, Rumænien
    - Novartis Investigative Site
- District 4
  - Bucuresti, District 4, Rumænien, 4204179
    - Novartis Investigative Site
- Jud Bihor
  - Oradea, Jud Bihor, Rumænien, 410169
    - Novartis Investigative Site
- Jud Cluj
  - Cluj Napoca, Jud Cluj, Rumænien, 400015
    - Novartis Investigative Site
- Jud Iasi
  - Iasi, Jud Iasi, Rumænien, 700732
    - Novartis Investigative Site
- Jud Mures
  - Targu Mures, Jud Mures, Rumænien, 540043
    - Novartis Investigative Site
- Jud. Constanta
  - Constanta, Jud. Constanta, Rumænien, 900591
    - Novartis Investigative Site
- Jud. Dolj
  - Craiova, Jud. Dolj, Rumænien, 200497
    - Novartis Investigative Site
- Jud. Iasi
  - Iasi, Jud. Iasi, Rumænien, 700111
    - Novartis Investigative Site
- Mures
  - Targu Mures, Mures, Rumænien, 540124
    - Novartis Investigative Site
  - Tg Mures, Mures, Rumænien, 540136
    - Novartis Investigative Site
- ROM
  - Braila, ROM, Rumænien, 810249
    - Novartis Investigative Site
- Timis
  - Timisoara, Timis, Rumænien, 300362
    - Novartis Investigative Site
Serbien
- - Beograd, Serbien, 11040
    - Novartis Investigative Site
  - Nis, Serbien, 18000
    - Novartis Investigative Site
  - Niska Banja, Serbien, 18205
    - Novartis Investigative Site
  - Sremska Kamenica, Serbien, 21204
    - Novartis Investigative Site
Slovakiet
- - Banska Bystrica, Slovakiet, 97401
    - Novartis Investigative Site
  - Bardejov, Slovakiet, 085 01
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 831 06
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 841 07
    - Novartis Investigative Site
  - Bratislava, Slovakiet, 81369
    - Novartis Investigative Site
  - Dubnica nad Vahom, Slovakiet, 01841
    - Novartis Investigative Site
  - Dunajska Streda, Slovakiet, 929 01
    - Novartis Investigative Site
  - Galanta, Slovakiet, 92701
    - Novartis Investigative Site
  - Kosice, Slovakiet, 040 01
    - Novartis Investigative Site
  - Kosice, Slovakiet, 04001
    - Novartis Investigative Site
  - Levice, Slovakiet, 934 01
    - Novartis Investigative Site
  - Lucenec, Slovakiet, 984 01
    - Novartis Investigative Site
  - Lucenec, Slovakiet, 98403
    - Novartis Investigative Site
  - Martin, Slovakiet, 036 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 949 01
    - Novartis Investigative Site
  - Nitra, Slovakiet, 94901
    - Novartis Investigative Site
  - Nove Zamky, Slovakiet, 940 01
    - Novartis Investigative Site
  - Nove Zamky, Slovakiet, 94002
    - Novartis Investigative Site
  - Presov, Slovakiet, 081 01
    - Novartis Investigative Site
  - Trnava, Slovakiet, 91702
    - Novartis Investigative Site
  - Zilina, Slovakiet, 012 07
    - Novartis Investigative Site
- Slovak Republic
  - Bratislava, Slovak Republic, Slovakiet, 826 06
    - Novartis Investigative Site
  - Brezno, Slovak Republic, Slovakiet, 977 42
    - Novartis Investigative Site
  - Komarno, Slovak Republic, Slovakiet, 94575
    - Novartis Investigative Site
  - Kosice, Slovak Republic, Slovakiet, 040 22
    - Novartis Investigative Site
  - Povazska Bystrica, Slovak Republic, Slovakiet, 017 01
    - Novartis Investigative Site
  - Presov, Slovak Republic, Slovakiet, 08001
    - Novartis Investigative Site
  - Presov, Slovak Republic, Slovakiet, 080 01
    - Novartis Investigative Site
  - Rimavska Sobota, Slovak Republic, Slovakiet, 97901
    - Novartis Investigative Site
  - Svidnik, Slovak Republic, Slovakiet, 08901
    - Novartis Investigative Site
  - Velky Krtis, Slovak Republic, Slovakiet, 990 01
    - Novartis Investigative Site
Slovenien
- - Celje, Slovenien, 3000
    - Novartis Investigative Site
  - Golnik, Slovenien, 4204
    - Novartis Investigative Site
  - Ljubljana, Slovenien, 1000
    - Novartis Investigative Site
Sverige
- - Boras, Sverige, 506 30
    - Novartis Investigative Site
  - Goteborg, Sverige, 416 85
    - Novartis Investigative Site
  - Kristianstad, Sverige, 291 85
    - Novartis Investigative Site
  - Luleå, Sverige, 972 33
    - Novartis Investigative Site
  - Lund, Sverige, 222 21
    - Novartis Investigative Site
  - Lund, Sverige, 22142
    - Novartis Investigative Site
  - Malmö, Sverige, 214 22
    - Novartis Investigative Site
  - Molndal, Sverige, 431 80
    - Novartis Investigative Site
  - Skanör, Sverige, 239 33
    - Novartis Investigative Site
  - Skelleftea, Sverige, 931 86
    - Novartis Investigative Site
  - Stockholm, Sverige, 118 83
    - Novartis Investigative Site
  - Stockholm, Sverige, SE-111 35
    - Novartis Investigative Site
  - Uddevalla, Sverige, 451 50
    - Novartis Investigative Site
  - Vallingby, Sverige, 162 68
    - Novartis Investigative Site
  - Vasteras, Sverige, 72189
    - Novartis Investigative Site
  - Östersund, Sverige, 831 83
    - Novartis Investigative Site
- Vastra Gotalands Lan
  - Göteborg, Vastra Gotalands Lan, Sverige, SE-413 45
    - Novartis Investigative Site
Sydafrika
- - Alberton, Sydafrika, 1449
    - Novartis Investigative Site
  - Bloemfontein, Sydafrika, 9301
    - Novartis Investigative Site
  - Cape Town, Sydafrika, 7925
    - Novartis Investigative Site
  - Cape Town, Sydafrika, 7405
    - Novartis Investigative Site
  - Centurion, Sydafrika, 4001
    - Novartis Investigative Site
  - Johannesburg, Sydafrika, 2193
    - Novartis Investigative Site
  - Kempton Park, Sydafrika, 1620
    - Novartis Investigative Site
  - Pretoria, Sydafrika, 0002
    - Novartis Investigative Site
  - Western Cape, Sydafrika, 7130
    - Novartis Investigative Site
- Kwa-Zulu Natal
  - Durban, Kwa-Zulu Natal, Sydafrika, 4052
    - Novartis Investigative Site
- Western Cape
  - Cape Town, Western Cape, Sydafrika, 7405
    - Novartis Investigative Site
Taiwan
- - Changhua, Taiwan, 50006
    - Novartis Investigative Site
  - Kaohsiung, Taiwan, 80756
    - Novartis Investigative Site
  - Kaohsiung City, Taiwan, 83301
    - Novartis Investigative Site
  - Taichung, Taiwan, 40447
    - Novartis Investigative Site
  - Tainan, Taiwan, 71004
    - Novartis Investigative Site
  - Taipei, Taiwan, 10002
    - Novartis Investigative Site
  - Taipei, Taiwan
    - Novartis Investigative Site
  - Taipei, Taiwan, 114
    - Novartis Investigative Site
  - Taipei, Taiwan, 10449
    - Novartis Investigative Site
  - Taoyuan, Taiwan, 33305
    - Novartis Investigative Site
  - Yilan, Taiwan, 26058
    - Novartis Investigative Site
- Taiwan ROC
  - Taichung, Taiwan ROC, Taiwan, 40201
    - Novartis Investigative Site
- Taiwan, ROC
  - Taipei, Taiwan, ROC, Taiwan, 11217
    - Novartis Investigative Site
Tjekkiet
- - Benesov, Tjekkiet, 25601
    - Novartis Investigative Site
  - Brno Bohunice, Tjekkiet, 625 00
    - Novartis Investigative Site
  - Broumov, Tjekkiet, 550 01
    - Novartis Investigative Site
  - Kolin, Tjekkiet, 280 20
    - Novartis Investigative Site
  - Marianske lazne, Tjekkiet, 353 01
    - Novartis Investigative Site
  - Pardubice, Tjekkiet, 530 02
    - Novartis Investigative Site
  - Prague 4 - Krc, Tjekkiet, 14059
    - Novartis Investigative Site
  - Praha, Tjekkiet, 12808
    - Novartis Investigative Site
  - Slany, Tjekkiet, 274 01
    - Novartis Investigative Site
  - Teplice, Tjekkiet, 415 29
    - Novartis Investigative Site
  - Uherske Hradiste, Tjekkiet, 68601
    - Novartis Investigative Site
- CZE
  - Most, CZE, Tjekkiet, 434 01
    - Novartis Investigative Site
  - Praha 2, CZE, Tjekkiet, 128 08
    - Novartis Investigative Site
  - Trutnov, CZE, Tjekkiet, 46063
    - Novartis Investigative Site
- Czech Republic
  - Brandys nad Labem, Czech Republic, Tjekkiet, 250 01
    - Novartis Investigative Site
  - Jablonec nad Nisou, Czech Republic, Tjekkiet, 466 01
    - Novartis Investigative Site
  - Kladno, Czech Republic, Tjekkiet, 272 80
    - Novartis Investigative Site
  - Liberec, Czech Republic, Tjekkiet, 460 05
    - Novartis Investigative Site
  - Louny, Czech Republic, Tjekkiet
    - Novartis Investigative Site
  - Ostrava, Czech Republic, Tjekkiet, 70200
    - Novartis Investigative Site
  - Plzen, Czech Republic, Tjekkiet, 301 00
    - Novartis Investigative Site
  - Praha 11, Czech Republic, Tjekkiet, 148 00
    - Novartis Investigative Site
  - Praha 9, Czech Republic, Tjekkiet
    - Novartis Investigative Site
  - Roznov pod Radhostem, Czech Republic, Tjekkiet, 756 61
    - Novartis Investigative Site
  - Semily, Czech Republic, Tjekkiet, 513 31
    - Novartis Investigative Site
  - Svitavy, Czech Republic, Tjekkiet, 568 25
    - Novartis Investigative Site
  - Trebic, Czech Republic, Tjekkiet, 674 01
    - Novartis Investigative Site
  - Usti nad Labem, Czech Republic, Tjekkiet, 400 01
    - Novartis Investigative Site
  - Usti nad Orlici, Czech Republic, Tjekkiet, 562 18
    - Novartis Investigative Site
  - Vyskov, Czech Republic, Tjekkiet, 68001
    - Novartis Investigative Site
  - Znojmo, Czech Republic, Tjekkiet, 66902
    - Novartis Investigative Site
Tyskland
- - Bad Krozingen, Tyskland, 79189
    - Novartis Investigative Site
  - Balve, Tyskland, 58802
    - Novartis Investigative Site
  - Berlin, Tyskland, 10117
    - Novartis Investigative Site
  - Berlin, Tyskland, 10367
    - Novartis Investigative Site
  - Berlin, Tyskland, 13353
    - Novartis Investigative Site
  - Berlin, Tyskland, 12627
    - Novartis Investigative Site
  - Berlin, Tyskland, 10789
    - Novartis Investigative Site
  - Berlin, Tyskland, 10629
    - Novartis Investigative Site
  - Berlin, Tyskland, 13055
    - Novartis Investigative Site
  - Bochum, Tyskland, 44787
    - Novartis Investigative Site
  - Borna, Tyskland, 04552
    - Novartis Investigative Site
  - Chemnitz, Tyskland, 09130
    - Novartis Investigative Site
  - Chemnitz, Tyskland, 09122
    - Novartis Investigative Site
  - Dillingen, Tyskland, 66763
    - Novartis Investigative Site
  - Dinslaken, Tyskland, 46535
    - Novartis Investigative Site
  - Dortmund, Tyskland, 44137
    - Novartis Investigative Site
  - Dresden, Tyskland, 01307
    - Novartis Investigative Site
  - Dresden, Tyskland, 01277
    - Novartis Investigative Site
  - Dresden, Tyskland, 01069
    - Novartis Investigative Site
  - Dresden, Tyskland, 01309
    - Novartis Investigative Site
  - Dresden, Tyskland, 01067
    - Novartis Investigative Site
  - Duisburg, Tyskland, 47137
    - Novartis Investigative Site
  - Düsseldorf, Tyskland, 40597
    - Novartis Investigative Site
  - Ebersbach, Tyskland, 02730
    - Novartis Investigative Site
  - Elsterwerda, Tyskland, 04910
    - Novartis Investigative Site
  - Erlangen, Tyskland, 91054
    - Novartis Investigative Site
  - Essen, Tyskland, 45276
    - Novartis Investigative Site
  - Essen, Tyskland, 45355
    - Novartis Investigative Site
  - Essen, Tyskland, 45136
    - Novartis Investigative Site
  - Falkensee, Tyskland, 14612
    - Novartis Investigative Site
  - Frankfurt, Tyskland, 60594
    - Novartis Investigative Site
  - Frankfurt, Tyskland, 60488
    - Novartis Investigative Site
  - Frankfurt am Main, Tyskland, 60313
    - Novartis Investigative Site
  - Freiburg, Tyskland, 79106
    - Novartis Investigative Site
  - Fulda, Tyskland, 36037
    - Novartis Investigative Site
  - Giengen, Tyskland, 89537
    - Novartis Investigative Site
  - Goerlitz, Tyskland, 02826
    - Novartis Investigative Site
  - Haag, Tyskland, 83527
    - Novartis Investigative Site
  - Halle Saale, Tyskland, 06120
    - Novartis Investigative Site
  - Hamburg, Tyskland, 20246
    - Novartis Investigative Site
  - Hamburg, Tyskland, 22041
    - Novartis Investigative Site
  - Hamburg, Tyskland, 22765
    - Novartis Investigative Site
  - Hamburg, Tyskland, 22393
    - Novartis Investigative Site
  - Hamburg, Tyskland, 22177
    - Novartis Investigative Site
  - Heidelberg, Tyskland, 69120
    - Novartis Investigative Site
  - Heilbronn, Tyskland, 74078
    - Novartis Investigative Site
  - Huy / OT Anderbeck, Tyskland, 38836
    - Novartis Investigative Site
  - Jerichow, Tyskland, 39319
    - Novartis Investigative Site
  - Kallstadt, Tyskland, 67169
    - Novartis Investigative Site
  - Kamp-Lintfort, Tyskland, 47475
    - Novartis Investigative Site
  - Kassel, Tyskland, 34127
    - Novartis Investigative Site
  - Kiel, Tyskland, 24119
    - Novartis Investigative Site
  - Koblenz, Tyskland, 56068
    - Novartis Investigative Site
  - Koeln, Tyskland, 51065
    - Novartis Investigative Site
  - Kuenzing, Tyskland, 94550
    - Novartis Investigative Site
  - Leipzig, Tyskland, 04103
    - Novartis Investigative Site
  - Leipzig, Tyskland, 04107
    - Novartis Investigative Site
  - Ludwigshafen, Tyskland, 67063
    - Novartis Investigative Site
  - Lüneburg, Tyskland, 21339
    - Novartis Investigative Site
  - Magdeburg, Tyskland, 39112
    - Novartis Investigative Site
  - Mainz, Tyskland, 55131
    - Novartis Investigative Site
  - Mainz, Tyskland, 55116
    - Novartis Investigative Site
  - Mayen, Tyskland, 56727
    - Novartis Investigative Site
  - Meissen, Tyskland, 01662
    - Novartis Investigative Site
  - Meißen, Tyskland, 01662
    - Novartis Investigative Site
  - Muehldorf Am Inn, Tyskland, 84453
    - Novartis Investigative Site
  - Muehlhausen, Tyskland, 99974
    - Novartis Investigative Site
  - Neuhofen, Tyskland, 67141
    - Novartis Investigative Site
  - Neunkirchen, Tyskland, 66539
    - Novartis Investigative Site
  - Northeim, Tyskland, 37154
    - Novartis Investigative Site
  - Nurnberg, Tyskland, 90402
    - Novartis Investigative Site
  - Oelde, Tyskland, 59302
    - Novartis Investigative Site
  - Oschatz, Tyskland, 04758
    - Novartis Investigative Site
  - Paderborn, Tyskland, 33098
    - Novartis Investigative Site
  - Potsdam, Tyskland, 14469
    - Novartis Investigative Site
  - Rednitzhembach, Tyskland, 91126
    - Novartis Investigative Site
  - Reinfeld, Tyskland, 23858
    - Novartis Investigative Site
  - Rostock, Tyskland, 06120
    - Novartis Investigative Site
  - Rüdersdorf, Tyskland, 15562
    - Novartis Investigative Site
  - Siegen, Tyskland, 57072
    - Novartis Investigative Site
  - Ulm, Tyskland, 89081
    - Novartis Investigative Site
  - Wolmirstedt, Tyskland, 39326
    - Novartis Investigative Site
- NRW
  - Muehlheim An Der Ruhr, NRW, Tyskland, 45468
    - Novartis Investigative Site
Ungarn
- - Budapest, Ungarn, 1125
    - Novartis Investigative Site
  - Budapest, Ungarn, 1145
    - Novartis Investigative Site
  - Budapest, Ungarn, 1083
    - Novartis Investigative Site
  - Budapest, Ungarn, 1134
    - Novartis Investigative Site
  - Budapest, Ungarn, 1122
    - Novartis Investigative Site
  - Budapest, Ungarn, H-1115
    - Novartis Investigative Site
  - Budapest, Ungarn, 1042
    - Novartis Investigative Site
  - Csongrad, Ungarn, 6640
    - Novartis Investigative Site
  - Debrecen, Ungarn, 4032
    - Novartis Investigative Site
  - Gyula, Ungarn, 5700
    - Novartis Investigative Site
  - Kistarcsa, Ungarn, 2143
    - Novartis Investigative Site
  - Komarom, Ungarn, 2921
    - Novartis Investigative Site
  - Miskolc, Ungarn, 3530
    - Novartis Investigative Site
  - Mosonmagyarovar, Ungarn, 9200
    - Novartis Investigative Site
  - Nyiregyháza, Ungarn, 4400
    - Novartis Investigative Site
  - Pecs, Ungarn, 7623
    - Novartis Investigative Site
  - Szeged, Ungarn, H 6725
    - Novartis Investigative Site
  - Szekesfehervar, Ungarn, H-8000
    - Novartis Investigative Site
  - Szentes, Ungarn, 6600
    - Novartis Investigative Site
- Zala
  - Zalaegerszeg, Zala, Ungarn, 8900
    - Novartis Investigative Site
Østrig
- - Graz, Østrig, A-8036
    - Novartis Investigative Site
  - Linz, Østrig, A-4010
    - Novartis Investigative Site
  - Linz, Østrig, 4010
    - Novartis Investigative Site
  - Saint Stefan, Østrig, 8511
    - Novartis Investigative Site
  - Salzburg, Østrig, A-5020
    - Novartis Investigative Site
  - Vienna, Østrig, 1030
    - Novartis Investigative Site
  - Wien, Østrig, A 1090
    - Novartis Investigative Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier for hovedundersøgelsen:

Skriftligt informeret samtykke
Mand eller Kvinde af ikke-fertil alder
Alder ≥ 18 år.
Spontan MI mindst 30 dage før randomisering. hsCRP ≥ 2 mg/L

Delstudie 1 Inklusion:

Alt inklusion fra hovedundersøgelse
Erhvervelse af evaluerbare baseline MRI-billeder af bilaterale carotisarterier af billeddannelseskernelaboratoriet

Delstudie 2 Inklusion:

Alt inkluderet fra hovedstudiet
T2D ved baseline i henhold til hovedprotokolkriterier og være på en stabil antihyperglykæmisk medicin i mindst 4 uger før baseline OGTT-testen
Vil gerne have OGTT-vurderingen startet inden kl. 10.00

Udelukkelseskriterier for hovedundersøgelsen:

Gravide eller ammende (ammende) kvinder
Kvinder i den fødedygtige alder
Enhver af følgende samtidige sygdomme
Planlagt koronar revaskularisering (PCI eller CABG)
Større ikke-hjertekirurgisk eller endoskopisk procedure inden for de seneste 6 måneder
CABG-operation med flere kar inden for de seneste 3 år
Symptomatiske patienter med klasse IV hjertesvigt (HF) (New York Heart Association [NYHA].
Ukontrolleret hypertension
Ukontrolleret diabetes
Anamnese eller tegn på aktiv tuberkulose (TB) infektion. Delstudie 1 Eksklusion
Alle Hovedudelukkelse
Patienter med tidligere carotisangioplastik, stenting eller carotis atherektomi
Patienter med kontraindikationer til MR-undersøgelse (hjerneaneurismeklemme, implanteret neural stimulator, implanteret pacemaker, pacemakertråde eller defibrillator, protetiske hjerteklapper, cochleaimplantat, okulært fremmedlegeme eller andet implanteret legeme, tatoveringer, implanteret insulinpumpe, metalfragmenter eller kugle)
Patienter tilbøjelige til klaustrofobi eller kendte angstlidelser
BMI > 40 kg/m2 Delstudie 2 Eksklusion
Denne delundersøgelse har ingen yderligere eksklusionskriterier.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Tredobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Canakinumab Dosis 50 mg Pivotal fase: Blind Canakinumab 50 mg kvartalsvis subkutan + standardbehandling. Udvidelsesfase: Skiftet til åbent Canakinumab 150 mg kvartalsvis subkutan + standardbehandling	Medicin: Canakinumab Andre navne: ACZ885 Medicin: Standard for pleje Standardbehandling efter MI-baggrundsterapi inkluderer, men er ikke begrænset til, lipidsænkende, antihypertensive, betablokkere og anti-blodpladebehandling efter behov.
Eksperimentel: Canakinumab Dosis 150 mg Pivotal fase: Skiftet til åbent Canakinumab 150 mg kvartalsvis subkutan + standardbehandling	Medicin: Canakinumab Andre navne: ACZ885 Medicin: Standard for pleje Standardbehandling efter MI-baggrundsterapi inkluderer, men er ikke begrænset til, lipidsænkende, antihypertensive, betablokkere og anti-blodpladebehandling efter behov.
Eksperimentel: Canakinumab Dosis 300 mg Pivotal fase: Blind Canakinumab 300 mg kvartalsvis subkutant (med en ekstra dosis i uge 2) + standardbehandling. Udvidelsesfase: Skiftet til åbent Canakinumab 150 mg kvartalsvis subkutan + standardbehandling	Medicin: Canakinumab Andre navne: ACZ885 Medicin: Standard for pleje Standardbehandling efter MI-baggrundsterapi inkluderer, men er ikke begrænset til, lipidsænkende, antihypertensive, betablokkere og anti-blodpladebehandling efter behov.
Placebo komparator: Placebo Pivotal fase: Blindet matchende placebo kvartalsvis subkutan + standardbehandlingsterapi. Udvidelsesfase: Skiftet til åbent Canakinumab 150 mg kvartalsvis subkutan + standardbehandling	Medicin: Placebo Medicin: Standard for pleje Standardbehandling efter MI-baggrundsterapi inkluderer, men er ikke begrænset til, lipidsænkende, antihypertensive, betablokkere og anti-blodpladebehandling efter behov.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Analyse af Core Phase First CEC Confirmed Major Adverse Cardiovascular Events (MACE) og dets komponenter Tidsramme: Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år	Tid til forekomst af CEC (Cardiovascular clinical events judication Committee) bekræftede MACE, som var et sammensat endepunkt bestående af CEC-bekræftet CV-død, CEC-bekræftet ikke-fatal MI, eller CEC-bekræftet ikke-fatalt slagtilfælde. Patienter med den CEC-bedømte dødsårsag "Ukendt" blev talt som CV (kardiovaskulær) død.	Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år
Delstudie 1 (kernefase): Ændring fra baseline i carotis plaque byrde i bifurkationsregionen af indeks carotis arterie Tidsramme: 24 måneder		24 måneder
Delstudie 2 (kernefase): Ændring fra baseline for insulinsekretionshastigheden (ISR) i forhold til glukose 0-30 min. Defineret som Φ30 = AUCISR 0-30 / AUCGluc 0-30 i gennemsnit gennem året 3, 4, 5 besøg Tidsramme: Fra randomisering op til cirka 6 år		Fra randomisering op til cirka 6 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Patienter med kernefase CEC bekræftet CV-død, ikke-dødelig MI, ikke-dødelig slagtilfælde eller hospitalsindlæggelse for ustabil angina, der kræver uplanlagt revaskularisering Tidsramme: Fra randomisering til afslutning af behandling pus 30 dage, op til cirka 6 år	Forekomst af det sammensatte kardiovaskulære endepunkt bestående af kardiovaskulær død, ikke-fatal MI, ikke-dødelig slagtilfælde eller hospitalsindlæggelse for ustabil angina, der kræver uplanlagt revaskularisering. MACE inkluderer CV død, ikke-dødelig MI og ikke-dødelig slagtilfælde. CEC = Clinical Endpoints Committee	Fra randomisering til afslutning af behandling pus 30 dage, op til cirka 6 år
Patienter med kernefase nyopstået type 2-diabetes blandt patienter med præ-diabetes ved randomisering Tidsramme: Fra randomisering op til cirka 6 år	Tid til CEC bekræftede ny indtræden af type 2-diabetes blandt dem med præ-diabetes ved randomisering (dvs. undtagen dem, der er normoglykæmiske ved baseline)	Fra randomisering op til cirka 6 år
Kernefase dødsfald af alle årsager, ikke-dødelig hjerteinfarkt eller ikke-dødelig slagtilfælde Tidsramme: Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år	Forekomst af det sammensatte endepunkt bestående af dødelighed af alle årsager, ikke-dødelig IM eller ikke-dødelig slagtilfælde	Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år
Kernefase Dødelighed af alle årsager Tidsramme: Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år	Antal deltagerdødsfald	Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år
Oversigt over uønskede hændelser (kernefase) Tidsramme: Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år	Sammenfatning af bivirkninger (AE'er) og alvorlige bivirkninger (SAE'er), der forekommer under den dobbeltblindede kernefase af undersøgelsen. AE'er/SAE'er er alle tegn eller symptomer, der opstår under undersøgelsesbehandlingen.	Fra randomisering til afslutning af behandling plus 30 dage, op til cirka 6 år
Oversigt over uønskede hændelser (udvidelsesfase) Tidsramme: Fra starten af forlængelsesfasen til afslutningen af behandlingen plus 30 dage, op til ca. 2 år	Sammenfatning af bivirkninger (AE'er) og alvorlige bivirkninger (SAE'er), der forekommer under forlængelsesfasen af undersøgelsen. AE'er/SAE'er er alle tegn eller symptomer, der opstår under undersøgelsesbehandlingen.	Fra starten af forlængelsesfasen til afslutningen af behandlingen plus 30 dage, op til ca. 2 år
Delstudie 1 (kernefase): Ændring fra baseline af det samlede karvægsareal ved 3. måned i bifurkationsregionen af indeks carotisarterie Tidsramme: 3 måneder		3 måneder
Delstudie 1 (kernefase): Gennemsnitlig samlet karvægsareal på tværs af venstre og højre halspulsåre ved 3. og 24. måned Tidsramme: 24 måneder		24 måneder
Delstudie 1 (kernefase): Ændring fra baseline i tilsvarende samlet karvægsareal i venstre og højre halspulsårer Tidsramme: 24 måneder		24 måneder
Delstudie 1 (kernefase): Eksistensen af et basislinje totalt karvægsareal ved behandlingsinteraktion samt konsistensen af behandlingseffekten på tværs af undergrupper Tidsramme: 24 måneder		24 måneder
Delstudie 2 (kernefase): Ændring fra baseline i insulinfølsomhedsindeks Tidsramme: Fra randomisering op til cirka 6 år		Fra randomisering op til cirka 6 år
Delstudie 2 (kernefase): Ændring fra baseline i OGTT-stimuleret område under kurve (AUC) 0-120 min. glukosekoncentration, insulinkoncentration, pro-insulinkoncentration og insulinkoncentration/glukosekoncentrationsforhold Tidsramme: Fra randomisering op til cirka 6 år		Fra randomisering op til cirka 6 år
Delstudie 2 (kernefase): Ændring fra baseline i fastende pro-insulin koncentration/insulin koncentrationsforhold Tidsramme: Fra randomisering op til cirka 6 år		Fra randomisering op til cirka 6 år
Delstudie 2 (kernefase): Ændring fra baseline i OGTT-stimuleret område under kurven (AUC) 0-120 min. C-peptidkoncentration Tidsramme: Fra randomisering op til cirka 6 år		Fra randomisering op til cirka 6 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Novartis Pharmaceuticals

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

11. april 2011

Primær færdiggørelse (Faktiske)

28. marts 2017

Studieafslutning (Faktiske)

14. april 2019

Datoer for studieregistrering

Først indsendt

29. marts 2011

Først indsendt, der opfyldte QC-kriterier

31. marts 2011

Først opslået (Skøn)

4. april 2011

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

22. januar 2020

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. januar 2020

Sidst verificeret

1. januar 2020

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CACZ885M2301
2010-022970-14 (EudraCT nummer)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Novartis er forpligtet til at dele med kvalificerede eksterne forskere, adgang til data på patientniveau og understøttende kliniske dokumenter fra kvalificerede undersøgelser. Disse anmodninger gennemgås og godkendes af et uafhængigt bedømmelsespanel på grundlag af videnskabelig fortjeneste. Alle opgivne data er anonymiseret for at respektere privatlivets fred for patienter, der har deltaget i forsøget i overensstemmelse med gældende love og regler.

Tilgængeligheden af denne forsøgsdata er i overensstemmelse med kriterierne og processen beskrevet på www.clinicalstudydatarequest.com

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Placebo

Galderma R&D

Afsluttet

Effekt af CD07805/47 Gel i Rosacea Flushing

Rosacea

Tyskland
SamA Pharmaceutical Co., Ltd

Ukendt

Kliniske forsøg for at vurdere effektiviteten og sikkerheden af HLIM

Akut bronkitis | Akut øvre luftvejsinfektion

Korea, Republikken
National Institute on Drug Abuse (NIDA)

Afsluttet

Virkninger af cannabisadministrationsveje på menneskelig ydeevne og farmakokinetik

Brug af cannabis

Forenede Stater
Akeso

Ikke rekrutterer endnu

En klinisk undersøgelse af AK120 hos unge med moderat til svær atopisk dermatitis

Atopisk dermatitis

Kina
AstraZeneca
Parexel; Spandauer Damm 130; 14050; Berlin, Germany

Afsluttet

Vurdering af sikkerhed, tolerabilitet og farmakodynamik efter administration af én dosis AZD8601 til mandlige patienter med type II diabetes mellitus (T2DM)

Mandlige forsøgspersoner med type II-diabetes (T2DM)

Tyskland
Cellmedis
Medical Network Sp. z o.o.

Ikke rekrutterer endnu

New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease: rEsults oF a Single-center, Randomized, Double-blind, Placebo-controlled Crossover Trial. (The RELIEF Trial) (RELIEF)

GERD (gastroøsofageal reflukssygdom) | NERD

Polen
Texas A&M University
Nutrabolt

Afsluttet

Glycemic Response of a Commercial Food Bar (NB16)

Glukose og insulinrespons
Heptares Therapeutics Limited

Afsluttet

Farmakokinetik af oral kapsel hos raske japanske vs. kaukasiske forsøgspersoner (HTL0018318)

Farmakokinetik | Sikkerhedsproblemer

Det Forenede Kongerige
Regado Biosciences, Inc.

Afsluttet

Safety, Tolerability and PK/PD of RB006 in a Healthy Volunteer SAD (SC101)

Sund frivillig

Forenede Stater
LifeMine Therapeutics

Rekruttering

En fase I-undersøgelse for at evaluere Life-001

Sunde frivillige

Australien

Kardiovaskulær risikoreduktionsundersøgelse (reduktion i tilbagevendende større CV-sygdomsbegivenheder) (CANTOS)

Et randomiseret, dobbeltblindt, placebokontrolleret, hændelsesdrevet forsøg med kvartalsvis subkutan canakinumab til forebyggelse af tilbagevendende kardiovaskulære hændelser blandt stabile post-myokardieinfarktpatienter med forhøjet hsCRP

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med Placebo

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Qatar

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer